|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
403-1030 |
0e+00 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 595.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 403 SLPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVG 482
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 483 YSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDI-ARFRPDLKLLISSATMDA 561
Cdd:COG1643 89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLqPALRPDLKLLVMSATLDA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 562 EKFSDYFDTAPIFSFPGRRYPVEINYT--SAPEADYMDAAIVTILTIHvREPLGDILVFFTGQEEIETAEEILKHRIRgl 639
Cdd:COG1643 169 ERFARLLGDAPVIESSGRTYPVEVRYRplPADERDLEDAVADAVREAL-AEEPGDILVFLPGEREIRRTAEALRGRLP-- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 640 gtkiRELIICPIYANLPSELQAKIFEPTPEGARKVVLATNIAETSLTIDGIKYVVDPGFSKMKSYNPRTGMESLLITPIS 719
Cdd:COG1643 246 ----PDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERIS 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 720 KASATQRAGRAGRTSPGKCYRLYTAFNYNNdLEENTVPEVQRTNLASVVLALKSLGIHDLINFDFMDPPPAEALVKSLEL 799
Cdd:COG1643 322 QASANQRAGRAGRLAPGICYRLWSEEDFAR-RPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARAL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 800 LFALGALNKLGELTKAGRRMAEFPLDPMLSKMIVVSDKYKCSDEIISIAAMLSIGGsifyrPKDKQVHADnarmnFHtgn 879
Cdd:COG1643 401 LQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERD-----PRRGAAGSD-----LL--- 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 880 vgdhiALLKVYSSWKETNfstqwcyENYIQVRSMKRARDIRDQlegLLERVEIDISSNLNELDSVRKSIVAGFFPHTAKL 959
Cdd:COG1643 468 -----ARLNLWRRLREQQ-------REFLSYLRLREWRDLARQ---LRRLLGEGANEEPADYEAIGLLLALAYPDRIARR 532
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22329903 960 QKN-GSYRTVKhpQT-VHIHPNSGLSQvlPRWVVYHELVLTSKEY-MRQVTELKPEWLIELAPHyyQLKDVEDA 1030
Cdd:COG1643 533 RGEgGRYLLAR--GRgAALFPGSPLAK--KEWLVAAELVGGAAEArIRLAAPIDPEWLEELAAH--LIKRYSEP 600
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
377-1020 |
2.33e-158 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 501.99 E-value: 2.33e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 377 DAMDAKQKSQDLAEK--TALEELQEVRRSLPIYTYRDQL---------LKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAG 445
Cdd:TIGR01967 28 DQDRAIAALAKFRERidAACDKVEARRQAVPEIRYPDNLpvsakrediAEAIAENQVVIIAGETGSGKTTQLPKICLELG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 446 YTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDE 525
Cdd:TIGR01967 108 RGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 526 AHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAEKFSDYFDTAPIFSFPGRRYPVEINY------TSAPEADYMDAA 599
Cdd:TIGR01967 188 AHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrplveeQEDDDLDQLEAI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 600 IVTILTIhVREPLGDILVFFTGQEEI-ETAEEILKHRIRGLGtkireliICPIYANLPSELQAKIFEptPEGARKVVLAT 678
Cdd:TIGR01967 268 LDAVDEL-FAEGPGDILIFLPGEREIrDAAEILRKRNLRHTE-------ILPLYARLSNKEQQRVFQ--PHSGRRIVLAT 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 679 NIAETSLTIDGIKYVVDPGFSKMKSYNPRTGMESLLITPISKASATQRAGRAGRTSPGKCYRLYTAFNYNNDlEENTVPE 758
Cdd:TIGR01967 338 NVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSR-PEFTDPE 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 759 VQRTNLASVVLALKSLGIHDLINFDFMDPPPAEALVKSLELLFALGALNK---LGELTKAGRRMAEFPLDPMLSKMIVVS 835
Cdd:TIGR01967 417 ILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDdeaEPQLTPIGRQLAQLPVDPRLARMLLEA 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 836 DKYKCSDEIISIAAMLSIgGSIFYRPKDKQVHADNARMNFHTGNvGDHIALLKVYSSWKE------TNFSTQWC---YEN 906
Cdd:TIGR01967 497 HRLGCLQEVLIIASALSI-QDPRERPMEKQQAADQAHARFKDPR-SDFLSRVNLWRHIEEqrqalsANQFRNACrkqYLN 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 907 YIQVRSMkraRDIRDQLEGLLERVEIDISSNLNELDSVRKSIVAGFFPHTAKLQKNGSYRTVKHpQTVHIHPNSGLSQVL 986
Cdd:TIGR01967 575 YLRVREW---QDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGARG-RKFHIFPGSPLFKKP 650
|
650 660 670
....*....|....*....|....*....|....
gi 22329903 987 PRWVVYHELVLTSKEYMRQVTELKPEWLIELAPH 1020
Cdd:TIGR01967 651 PKWVMAAELVETSKLYARLVAKIEPEWVEPVAGH 684
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
403-1020 |
7.36e-151 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 482.25 E-value: 7.36e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 403 SLPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVG 482
Cdd:PRK11131 72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCVG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 483 YSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAE 562
Cdd:PRK11131 152 YKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPE 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 563 KFSDYFDTAPIFSFPGRRYPVEINYTS-APEADYMD----AAIVTILTIHVREPLGDILVFFTGQEEI-ETAEEILKhri 636
Cdd:PRK11131 232 RFSRHFNNAPIIEVSGRTYPVEVRYRPiVEEADDTErdqlQAIFDAVDELGREGPGDILIFMSGEREIrDTADALNK--- 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 637 RGLgtkiRELIICPIYANLPSELQAKIFEptPEGARKVVLATNIAETSLTIDGIKYVVDPGFSKMKSYNPRTGMESLLIT 716
Cdd:PRK11131 309 LNL----RHTEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIE 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 717 PISKASATQRAGRAGRTSPGKCYRLYTAFNYNNDlEENTVPEVQRTNLASVVLALKSLGIHDLINFDFMDPPPAEALVKS 796
Cdd:PRK11131 383 PISQASANQRKGRCGRVSEGICIRLYSEDDFLSR-PEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDG 461
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 797 LELLFALGALNK-----LGELTKAGRRMAEFPLDPMLSKMIVVSDKYKCSDEIISIAAMLSIGGSiFYRPKDKQVHADNA 871
Cdd:PRK11131 462 VRLLEELGAITTdeqasAYKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDP-RERPMDKQQASDEK 540
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 872 RMNFHTGNvGDHIALLKVYSSWKE-------TNFSTQwC---YENYIQVRSMKrarDIRDQLEGLLERVEIDISSNLNEL 941
Cdd:PRK11131 541 HRRFADKE-SDFLAFVNLWNYLQEqqkalssNQFRRL-CrtdYLNYLRVREWQ---DIYTQLRQVVKELGIPVNSEPAEY 615
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 942 DSVRKSIVAGFFPHTA-KLQKNGSYRTVKHPQtVHIHPNSGLSQVLPRWVVYHELVLTSKEYMRQVTELKPEWLIELAPH 1020
Cdd:PRK11131 616 REIHTALLTGLLSHIGmKDAEKQEYTGARNAR-FSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQH 694
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
404-576 |
1.74e-117 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 358.35 E-value: 1.74e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRG-KVGCTQPRRVAAMSVAARVAQEMGVKLGHEVG 482
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGgKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 483 YSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAE 562
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160
|
170
....*....|....
gi 22329903 563 KFSDYFDTAPIFSF 576
Cdd:cd17974 161 KFSAFFDDAPIFRI 174
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
404-833 |
3.06e-109 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 359.08 E-value: 3.06e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIP-QYLHEAGYTkrGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVG 482
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPlALLDAPGIG--GKIIMLEPRRLAARSAAQRLASQLGEAVGQTVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 483 YSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDI-ARFRPDLKLLISSATMDA 561
Cdd:TIGR01970 79 YRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVqSSLREDLKILAMSATLDG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 562 EKFSDYFDTAPIFSFPGRRYPVEINYTSAPEADYMDAAIVTILTIHVREPLGDILVFFTGQEEIETAEEILKHRIRGlgt 641
Cdd:TIGR01970 159 ERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVSRAVEHALASETGSILVFLPGQAEIRRVQEQLAERLDS--- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 642 kirELIICPIYANLPSELQAKIFEPTPEGARKVVLATNIAETSLTIDGIKYVVDPGFSKMKSYNPRTGMESLLITPISKA 721
Cdd:TIGR01970 236 ---DVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQA 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 722 SATQRAGRAGRTSPGKCYRLYTAFNYNNdLEENTVPEVQRTNLASVVLALKSLGIHDLINFDFMDPPPAEALVKSLELLF 801
Cdd:TIGR01970 313 SATQRAGRAGRLEPGVCYRLWSEEQHQR-LPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVALAAARQLLQ 391
|
410 420 430
....*....|....*....|....*....|..
gi 22329903 802 ALGALNKLGELTKAGRRMAEFPLDPMLSKMIV 833
Cdd:TIGR01970 392 RLGALDAQGRLTAHGKAMAALGCHPRLAAMLL 423
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
403-851 |
1.93e-101 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 337.67 E-value: 1.93e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 403 SLPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIP-QYLHEAGYTkrGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEV 481
Cdd:PRK11664 3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGIN--GKIIMLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 482 GYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDI-ARFRPDLKLLISSATMD 560
Cdd:PRK11664 81 GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVqQGLRDDLKLLIMSATLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 561 AEKFSDYFDTAPIFSFPGRRYPVEINYTSAPEADYMDAAIVTILTIHVREPLGDILVFFTGQEEIETAEEILKHRIRglg 640
Cdd:PRK11664 161 NDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQLASRVA--- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 641 tkiRELIICPIYANLPSELQAKIFEPTPEGARKVVLATNIAETSLTIDGIKYVVDPGFSKMKSYNPRTGMESLLITPISK 720
Cdd:PRK11664 238 ---SDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQ 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 721 ASATQRAGRAGRTSPGKCYRLYTAFNYNNDLEENTvPEVQRTNLASVVLALKSLGIHDLINFDFMDPPPAEALVKSLELL 800
Cdd:PRK11664 315 ASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSE-PEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLL 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 22329903 801 FALGALNKLGELTKAGRRMAEFPLDPMLSKMIVVSDKYkcSDEIISIAAML 851
Cdd:PRK11664 394 QQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKED--DEAALATAAKL 442
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
399-577 |
6.32e-96 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 301.32 E-value: 6.32e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 399 EVRRSLPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLG 478
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 479 HEVGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSAT 558
Cdd:cd17971 81 QEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSAT 160
|
170
....*....|....*....
gi 22329903 559 MDAEKFSDYFDTAPIFSFP 577
Cdd:cd17971 161 LDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
420-575 |
4.86e-93 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 292.83 E-value: 4.86e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 420 HQVLVIVGDTGSGKTTQIPQYLHEAGYTK--RGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGYSIRFEDCTSDKTVL 497
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKggKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22329903 498 KYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAEKFSDYFDTAPIFS 575
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIH 158
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
404-575 |
8.98e-90 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 284.74 E-value: 8.98e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGY 483
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 484 SIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAEK 563
Cdd:cd17983 81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADK 160
|
170
....*....|..
gi 22329903 564 FSDYFDTAPIFS 575
Cdd:cd17983 161 FADFFGNVPIFT 172
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
396-575 |
6.41e-89 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 282.77 E-value: 6.41e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 396 ELQEVRRSLPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGK--VGCTQPRRVAAMSVAARVAQEM 473
Cdd:cd17973 5 EILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKklVACTQPRRVAAMSVAQRVAEEM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 474 GVKLGHEVGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLL 553
Cdd:cd17973 85 DVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLI 164
|
170 180
....*....|....*....|..
gi 22329903 554 ISSATMDAEKFSDYFDTAPIFS 575
Cdd:cd17973 165 VMSATLDAGKFQKYFDNAPLLK 186
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
404-574 |
6.84e-88 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 279.62 E-value: 6.84e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGY 483
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 484 SIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFR-----PDLKLLISSAT 558
Cdd:cd17978 81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSAT 160
|
170
....*....|....*.
gi 22329903 559 MDAEKFSDYFDTAPIF 574
Cdd:cd17978 161 LDADLFSEYFNGAPVL 176
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
404-570 |
1.72e-80 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 260.09 E-value: 1.72e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGK-VGCTQPRRVAAMSVAARVAQEMGVKLGHEVG 482
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRvVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 483 YSIRFEDCTSD-KTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDA 561
Cdd:cd17980 81 YCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
....*....
gi 22329903 562 EKFSDYFDT 570
Cdd:cd17980 161 EKFRDFFNQ 169
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
581-742 |
2.76e-77 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 250.53 E-value: 2.76e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 581 YPVEINYTSAP-----------EADYMDAAIVTILTIHVREPLGDILVFFTGQEEIETAEEILKHRIRGLGTKirELIIC 649
Cdd:cd18791 1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDLG--KLLVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 650 PIYANLPSELQAKIFEPTPEGARKVVLATNIAETSLTIDGIKYVVDPGFSKMKSYNPRTGMESLLITPISKASATQRAGR 729
Cdd:cd18791 79 PLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGR 158
|
170
....*....|...
gi 22329903 730 AGRTSPGKCYRLY 742
Cdd:cd18791 159 AGRTRPGKCYRLY 171
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
404-575 |
7.67e-71 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 233.21 E-value: 7.67e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGY 483
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 484 SIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDI-----ARFRPDLKLLISSAT 558
Cdd:cd17984 81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLfqeksPNRKEHLKVVVMSAT 160
|
170
....*....|....*..
gi 22329903 559 MDAEKFSDYFDTAPIFS 575
Cdd:cd17984 161 LELAKLSAFFGNCPVFD 177
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
404-573 |
1.22e-63 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 213.09 E-value: 1.22e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGY 483
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 484 SIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAEK 563
Cdd:cd17989 81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAER 160
|
170
....*....|
gi 22329903 564 FSDYFDTAPI 573
Cdd:cd17989 161 FSRHFNNAPI 170
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
404-566 |
3.59e-59 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 201.04 E-value: 3.59e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKR-----GKVGCTQPRRVAAMSVAARVAQEMGVkLG 478
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPesdnpGMIGITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 479 HEVGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPD--------- 549
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170
....*....|....*...
gi 22329903 550 -LKLLISSATMDAEKFSD 566
Cdd:cd17982 160 pLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
404-573 |
7.62e-58 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 196.51 E-value: 7.62e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKrgkVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGY 483
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH---IACTQPRRIACISLAKRVAFESLNQYGSKVAY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 484 SIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAEK 563
Cdd:cd17979 78 QIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIEL 157
|
170
....*....|
gi 22329903 564 FSDYFDTAPI 573
Cdd:cd17979 158 FSGYFEGAPV 167
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
404-574 |
2.28e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 186.97 E-value: 2.28e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEaGYTKRGK-----VGCTQPRRVAAMSVAARVAQEMG--VK 476
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILD-DAIERGKgsscrIVCTQPRRISAISVAERVAAERAesCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 477 LGHEVGYSIRFEDCTSDKTV-LKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLIS 555
Cdd:cd17981 80 LGNSTGYQIRLESRKPRKQGsILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILM 159
|
170
....*....|....*....
gi 22329903 556 SATMDAEKFSDYFDTAPIF 574
Cdd:cd17981 160 SATLNAEKFSDYFNNCPMI 178
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
404-573 |
2.15e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 181.19 E-value: 2.15e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEA----GYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGH 479
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNslqgPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 480 EVGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATM 559
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....
gi 22329903 560 DAEKFSDYFDTAPI 573
Cdd:cd17985 161 NAELFSDYFNSCPV 174
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
404-573 |
9.32e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 176.55 E-value: 9.32e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHE---AGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHE 480
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEyclSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 481 VGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMD 560
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160
|
170
....*....|...
gi 22329903 561 AEKFSDYFDTAPI 573
Cdd:cd17977 161 SSKLLSYYGNVPL 173
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
404-575 |
6.16e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 174.72 E-value: 6.16e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHE-----AGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLG 478
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllnGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 479 -----HEVGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLL 553
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|..
gi 22329903 554 ISSATMDAEKFSDYFDTAPIFS 575
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILR 182
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
404-575 |
1.08e-49 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 173.67 E-value: 1.08e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGY 483
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 484 SIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIAR-FRPDLKLLISSATMDAE 562
Cdd:cd17990 81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDGD 160
|
170
....*....|...
gi 22329903 563 KFSDYFDTAPIFS 575
Cdd:cd17990 161 GLAALLPEAPVVE 173
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
404-573 |
4.22e-49 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 171.94 E-value: 4.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRG--KVGCTQPRRVAAMSVAARVAQEMGVKLGHEV 481
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIpcRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 482 GYSIRFEDCTSDKTVLKYMTDGMLLRELL-GEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMD 560
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMaGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160
|
170
....*....|...
gi 22329903 561 AEKFSDYFDTAPI 573
Cdd:cd17987 161 VNLFIRYFGSCPV 173
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
404-573 |
1.02e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 170.74 E-value: 1.02e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGC----TQPRRVAAMSVAARVAQEMGVKLGH 479
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCnvviTQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 480 EVGYSIRFEDCTSDKT-VLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSAT 558
Cdd:cd17976 81 NVGYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*
gi 22329903 559 MDAEKFSDYFDTAPI 573
Cdd:cd17976 161 GDNQRLSRYFGGCPV 175
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
404-573 |
1.49e-44 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 158.91 E-value: 1.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIV-GDTGSGKTTQIPQYLHEAGYTKR---GKVGCTQPRRVAAMSVAARVAQEMGVKLGH 479
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQWCAEFALSRGfqkGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 480 EVGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATM 559
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPA 160
|
170
....*....|....
gi 22329903 560 DAEKFSDYFDTAPI 573
Cdd:cd17986 161 LEPKLRAFWGNPPV 174
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
365-573 |
1.05e-42 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 155.76 E-value: 1.05e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 365 IKESVMAGENYED-AMDAKQKSQD-LAEKTALEELQEVRRSLPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLH 442
Cdd:cd17972 18 IDEGPLAFATPEQiSMDLKNELMYqREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYIL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 443 EAgYTKRGKVG-----CTQPRRVAAMSVAARVAQEMGVKLGHEVGYSIRFEDCTSDK-TVLKYMTDGMLLRELlgEPDLA 516
Cdd:cd17972 98 DD-FIQNDRAAecnivVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPhASILFCTVGVLLRKL--EAGIR 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 22329903 517 SYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAEKFSDYFDTAPI 573
Cdd:cd17972 175 GISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPV 231
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
404-574 |
3.58e-39 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 143.80 E-value: 3.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 404 LPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAgYTKRGK---VGCTQPRRVAAMSVAARVAQEMGVKLGHE 480
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDH-YYKRGKycnIVVTQPRRIAAISIARRVSQEREWTLGSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 481 VGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPD-LKLLISSATM 559
Cdd:cd17988 80 VGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSATI 159
|
170
....*....|....*....
gi 22329903 560 DAEKFSDYFDT----APIF 574
Cdd:cd17988 160 SCKEFADYFTTpnnpAYVF 178
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
802-887 |
1.42e-27 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 106.97 E-value: 1.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 802 ALGALNKLGELTKAGRRMAEFPLDPMLSKMIVVSDKYKCSDEIISIAAMLSIGGsifYRPKDKQVHADNARMNFHTGNvG 881
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD---PRPKEKREDADAARRRFADPE-S 76
|
....*.
gi 22329903 882 DHIALL 887
Cdd:smart00847 77 DHLTLL 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
796-886 |
5.45e-27 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 105.78 E-value: 5.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 796 SLELLFALGALNKLGELTKAGRRMAEFPLDPMLSKMIVVSDKYKCSDEIISIAAMLSiGGSIFYRP---------KDKQV 866
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALS-VRDPFVQPnfldprsaaKAARR 79
|
90 100
....*....|....*....|....*
gi 22329903 867 HADNA-----RMNFHTGNVGDHIAL 886
Cdd:pfam04408 80 RRRAAdekarAKFARLDLEGDHLTL 104
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
944-1021 |
3.59e-26 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 102.72 E-value: 3.59e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 944 VRKSIVAGFFPHTAKL-QKNGSYRTVKHPQTVHIHPNSGLSQVL---PRWVVYHELVLTSKEYMRQVTELKPEWLIELAP 1019
Cdd:pfam07717 1 LRAALAAGLYPNVARRdPKGKGYTTLSDNQRVFIHPSSVLFNEKtfpPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 22329903 1020 HY 1021
Cdd:pfam07717 81 HI 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
415-574 |
7.56e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 106.04 E-value: 7.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 415 KAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGY-TKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGY------SIRF 487
Cdd:smart00487 19 ALLSGLRDVILAAPTGSGKTLAALLPALEALKrGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyggdskREQL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 488 EDCTSDKTVLKYMTDGMLLRELL-GEPDLASYSVVIVDEAHERTLS--TDILFGLVKdiaRFRPDLKLLISSATM--DAE 562
Cdd:smart00487 99 RKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAHRLLDGgfGDQLEKLLK---LLPKNVQLLLLSATPpeEIE 175
|
170
....*....|..
gi 22329903 563 KFSDYFDTAPIF 574
Cdd:smart00487 176 NLLELFLNDPVF 187
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
630-732 |
9.74e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 67.24 E-value: 9.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 630 EILKHRIRGLGTKIreliiCPIYANLPSELQAKIFEPTPEGARKVVLATNIAETSLTIDGIKYVVDPGFskmksynprtg 709
Cdd:smart00490 1 EELAELLKELGIKV-----ARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL----------- 64
|
90 100
....*....|....*....|...
gi 22329903 710 mesllitPISKASATQRAGRAGR 732
Cdd:smart00490 65 -------PWSPASYIQRIGRAGR 80
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
402-751 |
7.24e-13 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 72.70 E-value: 7.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 402 RSLPIYTYRdQLLKAVEEHQVLVIVGDTGSGKTTQIPQ------YLHeAGYTKRGKVGCTQPRRVAAMSVAaRVAQemgV 475
Cdd:PHA02653 162 ASLQPDVQL-KIFEAWISRKPVVLTGGTGVGKTSQVPKlllwfnYLF-GGFDNLDKIDPNFIERPIVLSLP-RVAL---V 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 476 KLgHEVGY--SIRFEDCTSDKTVLKY--MTD----------GMLL---RELLGEpdLASYSVVIVDEAHERTLSTDILFG 538
Cdd:PHA02653 236 RL-HSITLlkSLGFDEIDGSPISLKYgsIPDelintnpkpyGLVFsthKLTLNK--LFDYGTVIIDEVHEHDQIGDIIIA 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 539 LV-KDIARFRpdlKLLISSATM--DAEKFSDYFDTAPIFSFPG-RRYP---VEINYTSAPEADYMDAA-----IVTILTI 606
Cdd:PHA02653 313 VArKHIDKIR---SLFLMTATLedDRDRIKEFFPNPAFVHIPGgTLFPiseVYVKNKYNPKNKRAYIEeekknIVTALKK 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 607 HVREPLGDILVFFTGQEEIETAEEILKHRIRGLG--------TKIRElIICPIYANL-PSelqakifeptpegarkVVLA 677
Cdd:PHA02653 390 YTPPKGSSGIVFVASVSQCEEYKKYLEKRLPIYDfyiihgkvPNIDE-ILEKVYSSKnPS----------------IIIS 452
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22329903 678 TNIAETSLTIDGIKYVVDPGfskmKSYNPR--TGMESLlitpISKASATQRAGRAGRTSPGkcyrLYTAFnYNNDL 751
Cdd:PHA02653 453 TPYLESSVTIRNATHVYDTG----RVYVPEpfGGKEMF----ISKSMRTQRKGRVGRVSPG----TYVYF-YDLDL 515
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
600-732 |
2.95e-11 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 61.07 E-value: 2.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 600 IVTILTIHVREPLGDILVFFTGQEEIEtaEEILKHRirglgtkiRELIICPIYANLPSELQAKIFEPTPEGARKVVLATN 679
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLE--AELLLEK--------EGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATD 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 22329903 680 IAETSLTIDGIKYVVDpgfskmksYNPRTGMESLLitpiskasatQRAGRAGR 732
Cdd:pfam00271 73 VAERGLDLPDVDLVIN--------YDLPWNPASYI----------QRIGRAGR 107
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
423-558 |
2.02e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 57.03 E-value: 2.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 423 LVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQE--MGVKLG---HEVGYSIRFEDCTSDKTVL 497
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAERLRELfgPGIRVAvlvGGSSAEEREKNKLGDADII 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22329903 498 kYMTDGMLLRELLGE--PDLASYSVVIVDEAHERTLSTD-ILFGLVKDIARFRPDLKLLISSAT 558
Cdd:cd00046 84 -IATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRgALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
421-527 |
4.10e-07 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 50.63 E-value: 4.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 421 QVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEmgvklghEVGYSI-RFEDCTSDKTVLKY 499
Cdd:cd17931 2 QLTVLDLHPGAGKTTRVLPQIIREAIKKRLRTLVLAPTRVVAAEMYEALRGL-------PIRYRTgAVKEEHGGNEIVDY 74
|
90 100
....*....|....*....|....*...
gi 22329903 500 MTDGMLLRELLGEPDLASYSVVIVDEAH 527
Cdd:cd17931 75 MCHGTFTCRLLSPKRVPNYNLIIMDEAH 102
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
112-391 |
2.02e-06 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 52.07 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 112 KSSVSESRKSDKGKKR---FRKKSGQSDESDGEVAVREDSRHVRR---KVSEEDDGSESEEERVRDQKEREELEQHLKDR 185
Cdd:PTZ00121 1619 KIKAEELKKAEEEKKKveqLKKKEAEEKKKAEELKKAEEENKIKAaeeAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEA 1698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 186 DTARTrklTEQtLSKKEKEEaVRRANALEKDDLYSLRKVSRQEYLKKREQKKLDELRDEIEDEQYLFGGEKLTETELREF 265
Cdd:PTZ00121 1699 EEAKK---AEE-LKKKEAEE-KKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEI 1773
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 266 RYKKE--LYDLVKKRTQDEDNVEEYRIPDAYD-----QEGG------VDQEKRFSVAVQRYRDLDSTEKMNpfaEQEAWE 332
Cdd:PTZ00121 1774 RKEKEavIEEELDEEDEKRRMEVDKKIKDIFDnfaniIEGGkegnlvINDSKEMEDSAIKEVADSKNMQLE---EADAFE 1850
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 333 DHQIGKATLKFGAKNKQA-SDDYQFVFEDQINFIKESVMAGENYEDAMDAKQKSQDLAEK 391
Cdd:PTZ00121 1851 KHKFNKNNENGEDGNKEAdFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAGK 1910
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
409-562 |
9.19e-06 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 46.85 E-value: 9.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 409 YRDQL--LKAVEEHQVLVIVGDTGSGKTT--QIPqYLHEAGYTKRGKVG-CTQPRRVAA---MSVAARVAQEMGVKLGHE 480
Cdd:pfam00270 1 TPIQAeaIPAILEGRDVLVQAPTGSGKTLafLLP-ALEALDKLDNGPQAlVLAPTRELAeqiYEELKKLGKGLGLKVASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 481 VGYSIRFEDCTSDKTV-LKYMTDGMLLRELLGEPDLASYSVVIVDEAHErtlSTDILFG--LVKDIARFRPDLKLLISSA 557
Cdd:pfam00270 80 LGGDSRKEQLEKLKGPdILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR---LLDMGFGpdLEEILRRLPKKRQILLLSA 156
|
....*
gi 22329903 558 TMDAE 562
Cdd:pfam00270 157 TLPRN 161
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
112-424 |
4.63e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 4.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 112 KSSVSESRKSDKGKKRFRKKSgQSDESDGEVAVREDSRHVRRKVSEEDDGSESEEERVRDQKEREELEQHLKDRDTARTR 191
Cdd:PTZ00121 1450 KKKAEEAKKAEEAKKKAEEAK-KADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAK 1528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 192 KLTEqtlskKEKEEAVRRANALEK-DDLYSLRKVSRQEYLKKREQKKldelRDEIEDEQYLFGGEKLTETELREFRYKKE 270
Cdd:PTZ00121 1529 KAEE-----AKKADEAKKAEEKKKaDELKKAEELKKAEEKKKAEEAK----KAEEDKNMALRKAEEAKKAEEARIEEVMK 1599
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 271 LYDLVKKRTQDEDNVEEyripDAYDQEGGVDQEKRFSVAVQRYRDLDSTEKMNPFAEQEAWEDHQIGKATLKFGA-KNKQ 349
Cdd:PTZ00121 1600 LYEEEKKMKAEEAKKAE----EAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAeEDKK 1675
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22329903 350 ASDDYQFVFEDQinfikesvmagENYEDAMDAKQKSQDLAEKTALEELQEVRRSlpiytyrDQLLKAVEEHQVLV 424
Cdd:PTZ00121 1676 KAEEAKKAEEDE-----------KKAAEALKKEAEEAKKAEELKKKEAEEKKKA-------EELKKAEEENKIKA 1732
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
421-536 |
5.25e-05 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 43.87 E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 421 QVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVgysiRFEDCTSdktvlkym 500
Cdd:pfam13401 6 GILVLTGESGTGKTTLLRRLLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRALGLPLSGRL----SKEELLA-------- 73
|
90 100 110
....*....|....*....|....*....|....*.
gi 22329903 501 tdgMLLRELLgepDLASYSVVIVDEAHErtLSTDIL 536
Cdd:pfam13401 74 ---ALQQLLL---ALAVAVVLIIDEAQH--LSLEAL 101
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
112-399 |
1.50e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.90 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 112 KSSVSESRKSDKGKKRFRKKSGQSDESDGEVAVREDSRHVRR--------KVSEEDDGSESEEERVRDQKER-EELEQHL 182
Cdd:PTZ00121 1476 KKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKaeeakkadEAKKAEEAKKADEAKKAEEKKKaDELKKAE 1555
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 183 KDRDTARTRKLTEQTLSKKEKEEAVRRANALEKDD---------LYSLRKVSRQEYLKKREQKKL--DELRDEIEDEQYL 251
Cdd:PTZ00121 1556 ELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEearieevmkLYEEEKKMKAEEAKKAEEAKIkaEELKKAEEEKKKV 1635
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 252 FGGEKLTETELREFRYKKELYDLVKKRTQDEDNVEEYRIPDAYDQEGGVDQEKRFSVAVQRyrdldstekmnpfAEQEAW 331
Cdd:PTZ00121 1636 EQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKK-------------EAEEAK 1702
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22329903 332 EDHQIGKatlKFGAKNKQASddyQFVFEDQINFIKESVMAGENYEDAMDAKQKSQDLAEKTALEELQE 399
Cdd:PTZ00121 1703 KAEELKK---KEAEEKKKAE---ELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKK 1764
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
79-422 |
1.71e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.90 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 79 QKHEAEAAmlvrKQKTYALLDADDDEDEVVVEKKSSVSESRKSDKGKKRFRKKSGQSDESDGEVAVREDSRHVRRKVsEE 158
Cdd:PTZ00121 1355 AADEAEAA----EEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKA-EE 1429
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 159 DDGSESEEERVRDQKEREELEQhlKDRDTARTRKLTEQTLSKKEKEEAVRRANALEKDDlyslrkvsrqEYLKKREQ--K 236
Cdd:PTZ00121 1430 KKKADEAKKKAEEAKKADEAKK--KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD----------EAKKKAEEakK 1497
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 237 KLDELRDEIEDEQylfGGEKLTETElrEFRYKKELYDLVKKRTQDE-DNVEEYRIPDAYDQEggvdQEKRFSVAVQRYRD 315
Cdd:PTZ00121 1498 KADEAKKAAEAKK---KADEAKKAE--EAKKADEAKKAEEAKKADEaKKAEEKKKADELKKA----EELKKAEEKKKAEE 1568
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 316 LDSTEKMNPFAEQEAWEDHQIGKATLKFGAKNKQASDDYQfvfEDQINFIKESVMAGENYEDAMDAKQKSQDLAEKTAle 395
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMK---AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEA-- 1643
|
330 340
....*....|....*....|....*..
gi 22329903 396 elQEVRRSlpiytyrDQLLKAVEEHQV 422
Cdd:PTZ00121 1644 --EEKKKA-------EELKKAEEENKI 1661
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
117-399 |
5.59e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.36 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 117 ESRKSDKGKKRFRKKSGQSDESDGEVAVREDSRHVRRKvseeddgSESEEERVRDQKEREELEQHLKDRDTARTRKLTEQ 196
Cdd:PTZ00121 1532 EAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEA-------KKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEE 1604
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 197 TLSKKEK----EEAVRRANALEKDDlySLRKVSRQEYLKKREQ-KKLDELRDeiEDEQYLFGGEKLTETELREFRYKKEL 271
Cdd:PTZ00121 1605 KKMKAEEakkaEEAKIKAEELKKAE--EEKKKVEQLKKKEAEEkKKAEELKK--AEEENKIKAAEEAKKAEEDKKKAEEA 1680
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 272 ydlvKKRTQDEDNVEEYRIPDAYDQEGGVDQEKRFSVAVQRYRDLDSTEKMNPF----AEQEAWEDHQIG-KATLKFGAK 346
Cdd:PTZ00121 1681 ----KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIkaeeAKKEAEEDKKKAeEAKKDEEEK 1756
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 22329903 347 NK-QASDDYQFVFEDQINFIKESVMA----GENYEDAMDAKQKSQDLaeKTALEELQE 399
Cdd:PTZ00121 1757 KKiAHLKKEEEKKAEEIRKEKEAVIEeeldEEDEKRRMEVDKKIKDI--FDNFANIIE 1812
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
673-742 |
1.23e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.45 E-value: 1.23e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22329903 673 KVVLATNIAETSLTIDGIKYVVDPGFskmksynprtgmesllitPISKASATQRAGRAGR--TSPGKCYRLY 742
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDP------------------PSSAASYIQRVGRAGRggKDEGEVILFV 77
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
416-526 |
2.03e-03 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 40.63 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 416 AVEEHQVLVIVGDTGSGKTT---QIPQYLHEAGYTKRGkvgctqprrvAAMSvaARVAQEMGVKLGHEVgysirfedcts 492
Cdd:pfam13604 14 LTSGDRVAVLVGPAGTGKTTalkALREAWEAAGYRVIG----------LAPT--GRAAKVLGEELGIPA----------- 70
|
90 100 110
....*....|....*....|....*....|....
gi 22329903 493 dktvlkyMTDGMLLRELLGEPDLASYSVVIVDEA 526
Cdd:pfam13604 71 -------DTIAKLLHRLGGRAGLDPGTLLIVDEA 97
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
613-732 |
3.04e-03 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 39.08 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 613 GDILVFFTGQEEIETAEEILKHrirglgTKIReliICPIYANLPSEL---QAKIFEpTPEGARKVVLATNIAETSLTIDg 689
Cdd:cd18805 19 GDCVVAFSRKDIFSLKREIEKR------TGLK---CAVIYGALPPETrrqQARLFN-DPESGYDVLVASDAIGMGLNLN- 87
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 22329903 690 IKYVVdpgFSKMKSYNprtGMEsllITPISKASATQRAGRAGR 732
Cdd:cd18805 88 IRRVI---FSSLSKFD---GNE---MRPLSPSEVKQIAGRAGR 121
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
172-313 |
6.49e-03 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 40.73 E-value: 6.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 172 QKEREELEQHLKDRDTARTRKLTEQTLSKKEKEEAVRRANALEKDDLYSLRKVSRQEYLKKREQKKLDELRDEI-EDEQY 250
Cdd:pfam02463 362 EKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEeESIEL 441
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22329903 251 LFGGEKLTETELREFRYKKELYDLVKKRTQDEDNVEEYRIPDAYDQEGGVDQEKRFSVAVQRY 313
Cdd:pfam02463 442 KQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESK 504
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
410-577 |
9.30e-03 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 38.40 E-value: 9.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 410 RDQLLKAVEEHQVLVIVGDTGSGKTT----QIPQYLHEAGytkrGKVGCTQPRRvaamSVAARVAQEMGVKLGHEVGYSI 485
Cdd:cd17921 7 REALRALYLSGDSVLVSAPTSSGKTLiaelAILRALATSG----GKAVYIAPTR----ALVNQKEADLRERFGPLGKNVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22329903 486 RfedCTSDKTVLKY---------MT----DGMLLRelLGEPDLASYSVVIVDEAH-----ERtlsTDILFGLVKDIARFR 547
Cdd:cd17921 79 L---LTGDPSVNKLllaeadilvATpeklDLLLRN--GGERLIQDVRLVVVDEAHligdgER---GVVLELLLSRLLRIN 150
|
170 180 190
....*....|....*....|....*....|.
gi 22329903 548 PDLKLLISSATMD-AEKFSDYFDTAPIFSFP 577
Cdd:cd17921 151 KNARFVGLSATLPnAEDLAEWLGVEDLIRFD 181
|
|
| |
