|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
240-834 |
1.29e-132 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 426.42 E-value: 1.29e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 240 DLPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGskqfssRSGIIGITQPRRVAVLATAKRVAFELGVR 319
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWG------AGGRIGMLEPRRLAARAAAERMAEELGEP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 320 LGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVI-KIRQEyyeeqq 398
Cdd:COG1643 83 VGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPD------ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 399 kslqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNiPPLIEVPTRQYPVTIHF----SKKTEIVDYIGEAYKKV 474
Cdd:COG1643 157 -----------------LKLLVMSATLDAERF---ARLLGD-APVIESSGRTYPVEVRYrplpADERDLEDAVADAVREA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 475 MSIHkklpQGGILVFVTGQREVdylceklrksskelvvqaakRDAyvkkkcddgsfggvdmkeiaeafdddsnnqnsrfs 554
Cdd:COG1643 216 LAEE----PGDILVFLPGEREI--------------------RRT----------------------------------- 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 555 shgedpsdigdgnydddfeeedmyesdedrdwetvddgfassfveegkldalraafnaladkngsvsaepaksiaaenqe 634
Cdd:COG1643 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 635 AEQVKNKFSPGkLRVLPLYAMLSPAAQLRVFEEVEKEERLVVVATNVAETSLTIPGIKYVVDTGRVKVKNYDSKTGMESY 714
Cdd:COG1643 237 AEALRGRLPPD-TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRL 315
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 715 EVDWISQASASQRAGRAGRTGPGHCYRLYSSAVFSNiFEESSLPEIMKVPVDGVILLMKSMNIPKVENFPFPTPPEPSAI 794
Cdd:COG1643 316 PTERISQASANQRAGRAGRLAPGICYRLWSEEDFAR-RPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAI 394
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 15217524 795 REAERCLKALEALDSNGGLTPLGKAMSHYPMSPRHSRMLL 834
Cdd:COG1643 395 ADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLL 434
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
241-446 |
4.16e-116 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 358.98 E-value: 4.16e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKQfSSRSGIIGITQPRRVAVLATAKRVAFELGVrL 320
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPE-SDNPGMIGITQPRRVAAVSMAKRVAEELNV-F 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEYYEeqqks 400
Cdd:cd17982 79 GKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLYL----- 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15217524 401 lqsggtvtSECQITPLKLILMSATLRVEDFVSGKRLFPNIPPLIEV 446
Cdd:cd17982 154 --------QDQTVKPLKLVIMSATLRVEDFTENKLLFPRPPPVIKV 191
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
230-1085 |
1.46e-97 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 339.82 E-value: 1.46e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 230 RPAEVEETRKD--LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKqfssrsGIIGITQPRRVAVLA 307
Cdd:TIGR01967 53 RRQAVPEIRYPdnLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSH------GLIGHTQPRRLAART 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 308 TAKRVAFELGVRLGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVI 387
Cdd:TIGR01967 127 VAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 388 KIRQEyyeeqqkslqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNiPPLIEVPTRQYPVTIHFSKKTEI---- 463
Cdd:TIGR01967 207 PRRPD-----------------------LKIIITSATIDPERF---SRHFNN-APIIEVSGRTYPVEVRYRPLVEEqedd 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 464 -VDYIGEAYKKVMSIHKKLPqGGILVFVTGQREVdylceklrksskelvvqaakRDAyvkkkcddgsfggvdmkeiaeaf 542
Cdd:TIGR01967 260 dLDQLEAILDAVDELFAEGP-GDILIFLPGEREI--------------------RDA----------------------- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 543 dddsnnqnsrfsshgedpsdigdgnydddfeeedmyesdedrdwetvddgfassfveegkldalraafnaladkngsvsa 622
Cdd:TIGR01967 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 623 epaksiaaenqeAEQVkNKFSPGKLRVLPLYAMLSPAAQLRVFEEVEKeeRLVVVATNVAETSLTIPGIKYVVDTGRVKV 702
Cdd:TIGR01967 296 ------------AEIL-RKRNLRHTEILPLYARLSNKEQQRVFQPHSG--RRIVLATNVAETSLTVPGIHYVIDTGTARI 360
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 703 KNYDSKTGMESYEVDWISQASASQRAGRAGRTGPGHCYRLYSSAVFSNiFEESSLPEIMKVPVDGVILLMKSMNIPKVEN 782
Cdd:TIGR01967 361 SRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS-RPEFTDPEILRTNLASVILQMLALRLGDIAA 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 783 FPFPTPPEPSAIREAERCLKALEALDSNGG---LTPLGKAMSHYPMSPRHSRMLLTVIQM--LKETrnysranLILgyav 857
Cdd:TIGR01967 440 FPFIEAPDPRAIRDGFRLLEELGALDDDEAepqLTPIGRQLAQLPVDPRLARMLLEAHRLgcLQEV-------LII---- 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 858 aaVAALSLPNPlimefegekkneskdadktvkqedKQRKKDRKEKIKAARDRFSNPSSDALTVAYALHSFEVSENGMgfc 937
Cdd:TIGR01967 509 --ASALSIQDP------------------------RERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQAL--- 559
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 938 EANGLHlktmdemSKLKDQLLrlvfNCCKPSETEDSFSWTHGTIQDVekSWRIttstsSKTPllqNEEELLGEAICAGWA 1017
Cdd:TIGR01967 560 SANQFR-------NACRKQYL----NYLRVREWQDIYRQLTQVVKEL--GLKL-----NEEP---ADYDAIHKALLSGLL 618
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15217524 1018 DRVARKTRATEYQAcAVQEPVFLHRWSSLINSAPELLVYSELLLTNRPYMHGATRVRPEWLVKHAKSL 1085
Cdd:TIGR01967 619 SQIGMKDEKHEYDG-ARGRKFHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGHL 685
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
240-838 |
6.07e-87 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 308.91 E-value: 6.07e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 240 DLPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKqfssrsGIIGITQPRRVAVLATAKRVAFELGVR 319
Cdd:PRK11131 72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK------GLIGHTQPRRLAARTVANRIAEELETE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 320 LGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqk 399
Cdd:PRK11131 146 LGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD------- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 400 slqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNiPPLIEVPTRQYPVTIHFSKKTE------------IVDYI 467
Cdd:PRK11131 219 ----------------LKVIITSATIDPERF---SRHFNN-APIIEVSGRTYPVEVRYRPIVEeaddterdqlqaIFDAV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 468 GEAYKKvmsihkklPQGGILVFVTGQREVdylceklrksskelvvqaakRDAyvkkkcddgsfggvdmkeiAEAFdddsN 547
Cdd:PRK11131 279 DELGRE--------GPGDILIFMSGEREI--------------------RDT-------------------ADAL----N 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 548 NQNSRfssHGEdpsdigdgnydddfeeedmyesdedrdwetvddgfassfveegkldalraafnaladkngsvsaepaks 627
Cdd:PRK11131 308 KLNLR---HTE--------------------------------------------------------------------- 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 628 iaaenqeaeqvknkfspgklrVLPLYAMLSPAAQLRVFEevEKEERLVVVATNVAETSLTIPGIKYVVDTGRVKVKNYDS 707
Cdd:PRK11131 316 ---------------------ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSY 372
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 708 KTGMESYEVDWISQASASQRAGRAGRTGPGHCYRLYSSAVFSNiFEESSLPEIMKVPVDGVILLMKSMNIPKVENFPFPT 787
Cdd:PRK11131 373 RTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLS-RPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVE 451
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 15217524 788 PPEPSAIREAERCLKALEALDSNGG-----LTPLGKAMSHYPMSPRHSRMLLTVIQ 838
Cdd:PRK11131 452 APDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARMVLEAQK 507
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
250-456 |
4.50e-20 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 89.86 E-value: 4.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 250 IMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGfgskqFSSRSGIIGITQPRRVAVLATAKRVAFELGVRLGKEVGFQVR 329
Cdd:smart00487 17 IEALLSGLRDVILAAPTGSGKTLAALLPALEAL-----KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 330 YDKK------IGENSSIKFMTDGILLREIQNDFL-LRRYSVIILDEAHERS--LNTDILIGMLTRVIKIRQeyyeeqqks 400
Cdd:smart00487 92 DSKReqlrklESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNVQ--------- 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15217524 401 lqsggtvtsecqitplkLILMSATLRVEDFVSGKRLFPNIPPLIEVPTRQYPVTIH 456
Cdd:smart00487 163 -----------------LLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1011-1085 |
5.52e-19 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 82.69 E-value: 5.52e-19
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15217524 1011 AICAGWADRVARKTRAT-EYQACAVQEPVFLHRWSSLIN---SAPELLVYSELLLTNRPYMHGATRVRPEWLVKHAKSL 1085
Cdd:pfam07717 4 ALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNektFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAPHI 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
797-920 |
3.91e-18 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 80.74 E-value: 3.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 797 AERCLKALEALDSNGGLTPLGKAMSHYPMSPRHSRMLLTVIQM--LKETrnysranLILgyavaaVAALSLPNPLIMEFE 874
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELgcLDEV-------LTI------VAALSVRDPFVQPNF 67
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 15217524 875 GEKKNESKDADKtvkqedKQRKKDRKEKIKAARDRFsnpSSDALTV 920
Cdd:pfam04408 68 LDPRSAAKAARR------RRRAADEKARAKFARLDL---EGDHLTL 104
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
646-735 |
2.66e-12 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 64.54 E-value: 2.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 646 KLRVLPLYAMLSPAAQLRVFEEVEKEERLVVVATNVAETSLTIPGIKYVVdtgrvkvkNYDSKTGMESYEvdwisqasas 725
Cdd:pfam00271 38 GIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVI--------NYDLPWNPASYI---------- 99
|
90
....*....|
gi 15217524 726 QRAGRAGRTG 735
Cdd:pfam00271 100 QRIGRAGRAG 109
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
803-919 |
1.44e-11 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 61.52 E-value: 1.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 803 ALEALDSNGGLTPLGKAMSHYPMSPRHSRMLLTVIQMlketrNYSRANLILgyavaaVAALSLPNPlimefegekknesk 882
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEF-----GCLDEILTI------VAMLSVGDP-------------- 55
|
90 100 110
....*....|....*....|....*....|....*..
gi 15217524 883 dadktvkqedkqRKKDRKEKIKAARDRFSNPSSDALT 919
Cdd:smart00847 56 ------------RPKEKREDADAARRRFADPESDHLT 80
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
240-834 |
1.29e-132 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 426.42 E-value: 1.29e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 240 DLPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGskqfssRSGIIGITQPRRVAVLATAKRVAFELGVR 319
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWG------AGGRIGMLEPRRLAARAAAERMAEELGEP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 320 LGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVI-KIRQEyyeeqq 398
Cdd:COG1643 83 VGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPD------ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 399 kslqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNiPPLIEVPTRQYPVTIHF----SKKTEIVDYIGEAYKKV 474
Cdd:COG1643 157 -----------------LKLLVMSATLDAERF---ARLLGD-APVIESSGRTYPVEVRYrplpADERDLEDAVADAVREA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 475 MSIHkklpQGGILVFVTGQREVdylceklrksskelvvqaakRDAyvkkkcddgsfggvdmkeiaeafdddsnnqnsrfs 554
Cdd:COG1643 216 LAEE----PGDILVFLPGEREI--------------------RRT----------------------------------- 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 555 shgedpsdigdgnydddfeeedmyesdedrdwetvddgfassfveegkldalraafnaladkngsvsaepaksiaaenqe 634
Cdd:COG1643 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 635 AEQVKNKFSPGkLRVLPLYAMLSPAAQLRVFEEVEKEERLVVVATNVAETSLTIPGIKYVVDTGRVKVKNYDSKTGMESY 714
Cdd:COG1643 237 AEALRGRLPPD-TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRL 315
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 715 EVDWISQASASQRAGRAGRTGPGHCYRLYSSAVFSNiFEESSLPEIMKVPVDGVILLMKSMNIPKVENFPFPTPPEPSAI 794
Cdd:COG1643 316 PTERISQASANQRAGRAGRLAPGICYRLWSEEDFAR-RPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAI 394
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 15217524 795 REAERCLKALEALDSNGGLTPLGKAMSHYPMSPRHSRMLL 834
Cdd:COG1643 395 ADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLL 434
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
241-446 |
4.16e-116 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 358.98 E-value: 4.16e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKQfSSRSGIIGITQPRRVAVLATAKRVAFELGVrL 320
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPE-SDNPGMIGITQPRRVAAVSMAKRVAEELNV-F 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEYYEeqqks 400
Cdd:cd17982 79 GKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLYL----- 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15217524 401 lqsggtvtSECQITPLKLILMSATLRVEDFVSGKRLFPNIPPLIEV 446
Cdd:cd17982 154 --------QDQTVKPLKLVIMSATLRVEDFTENKLLFPRPPPVIKV 191
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
230-1085 |
1.46e-97 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 339.82 E-value: 1.46e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 230 RPAEVEETRKD--LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKqfssrsGIIGITQPRRVAVLA 307
Cdd:TIGR01967 53 RRQAVPEIRYPdnLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSH------GLIGHTQPRRLAART 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 308 TAKRVAFELGVRLGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVI 387
Cdd:TIGR01967 127 VAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 388 KIRQEyyeeqqkslqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNiPPLIEVPTRQYPVTIHFSKKTEI---- 463
Cdd:TIGR01967 207 PRRPD-----------------------LKIIITSATIDPERF---SRHFNN-APIIEVSGRTYPVEVRYRPLVEEqedd 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 464 -VDYIGEAYKKVMSIHKKLPqGGILVFVTGQREVdylceklrksskelvvqaakRDAyvkkkcddgsfggvdmkeiaeaf 542
Cdd:TIGR01967 260 dLDQLEAILDAVDELFAEGP-GDILIFLPGEREI--------------------RDA----------------------- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 543 dddsnnqnsrfsshgedpsdigdgnydddfeeedmyesdedrdwetvddgfassfveegkldalraafnaladkngsvsa 622
Cdd:TIGR01967 --------------------------------------------------------------------------------
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 623 epaksiaaenqeAEQVkNKFSPGKLRVLPLYAMLSPAAQLRVFEEVEKeeRLVVVATNVAETSLTIPGIKYVVDTGRVKV 702
Cdd:TIGR01967 296 ------------AEIL-RKRNLRHTEILPLYARLSNKEQQRVFQPHSG--RRIVLATNVAETSLTVPGIHYVIDTGTARI 360
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 703 KNYDSKTGMESYEVDWISQASASQRAGRAGRTGPGHCYRLYSSAVFSNiFEESSLPEIMKVPVDGVILLMKSMNIPKVEN 782
Cdd:TIGR01967 361 SRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS-RPEFTDPEILRTNLASVILQMLALRLGDIAA 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 783 FPFPTPPEPSAIREAERCLKALEALDSNGG---LTPLGKAMSHYPMSPRHSRMLLTVIQM--LKETrnysranLILgyav 857
Cdd:TIGR01967 440 FPFIEAPDPRAIRDGFRLLEELGALDDDEAepqLTPIGRQLAQLPVDPRLARMLLEAHRLgcLQEV-------LII---- 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 858 aaVAALSLPNPlimefegekkneskdadktvkqedKQRKKDRKEKIKAARDRFSNPSSDALTVAYALHSFEVSENGMgfc 937
Cdd:TIGR01967 509 --ASALSIQDP------------------------RERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQAL--- 559
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 938 EANGLHlktmdemSKLKDQLLrlvfNCCKPSETEDSFSWTHGTIQDVekSWRIttstsSKTPllqNEEELLGEAICAGWA 1017
Cdd:TIGR01967 560 SANQFR-------NACRKQYL----NYLRVREWQDIYRQLTQVVKEL--GLKL-----NEEP---ADYDAIHKALLSGLL 618
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15217524 1018 DRVARKTRATEYQAcAVQEPVFLHRWSSLINSAPELLVYSELLLTNRPYMHGATRVRPEWLVKHAKSL 1085
Cdd:TIGR01967 619 SQIGMKDEKHEYDG-ARGRKFHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGHL 685
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
240-838 |
6.07e-87 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 308.91 E-value: 6.07e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 240 DLPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKqfssrsGIIGITQPRRVAVLATAKRVAFELGVR 319
Cdd:PRK11131 72 NLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVK------GLIGHTQPRRLAARTVANRIAEELETE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 320 LGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqk 399
Cdd:PRK11131 146 LGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD------- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 400 slqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNiPPLIEVPTRQYPVTIHFSKKTE------------IVDYI 467
Cdd:PRK11131 219 ----------------LKVIITSATIDPERF---SRHFNN-APIIEVSGRTYPVEVRYRPIVEeaddterdqlqaIFDAV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 468 GEAYKKvmsihkklPQGGILVFVTGQREVdylceklrksskelvvqaakRDAyvkkkcddgsfggvdmkeiAEAFdddsN 547
Cdd:PRK11131 279 DELGRE--------GPGDILIFMSGEREI--------------------RDT-------------------ADAL----N 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 548 NQNSRfssHGEdpsdigdgnydddfeeedmyesdedrdwetvddgfassfveegkldalraafnaladkngsvsaepaks 627
Cdd:PRK11131 308 KLNLR---HTE--------------------------------------------------------------------- 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 628 iaaenqeaeqvknkfspgklrVLPLYAMLSPAAQLRVFEevEKEERLVVVATNVAETSLTIPGIKYVVDTGRVKVKNYDS 707
Cdd:PRK11131 316 ---------------------ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSY 372
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 708 KTGMESYEVDWISQASASQRAGRAGRTGPGHCYRLYSSAVFSNiFEESSLPEIMKVPVDGVILLMKSMNIPKVENFPFPT 787
Cdd:PRK11131 373 RTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLS-RPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVE 451
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 15217524 788 PPEPSAIREAERCLKALEALDSNGG-----LTPLGKAMSHYPMSPRHSRMLLTVIQ 838
Cdd:PRK11131 452 APDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARMVLEAQK 507
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
257-446 |
3.34e-69 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 228.88 E-value: 3.34e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 257 HPAVIISGQTGCGKTTQVPQFLYEAGFGSKQfssrSGIIGITQPRRVAVLATAKRVAFELGVRLGKEVGFQVRYDKKIGE 336
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGG----KGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 337 NSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqkslqsggtvtsecqitpL 416
Cdd:cd17917 77 KTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPD-----------------------L 133
|
170 180 190
....*....|....*....|....*....|
gi 15217524 417 KLILMSATLRVEDFVSgkrlFPNIPPLIEV 446
Cdd:cd17917 134 KVILMSATLDAEKFSS----YFGGAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
241-430 |
2.60e-67 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 224.16 E-value: 2.60e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGskqfssRSGIIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFA------RGGMIGITQPRRVAAVSVAKRVAEEMGVEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRqeyyEEQQKS 400
Cdd:cd17978 75 GQLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRR----KEQKLS 150
|
170 180 190
....*....|....*....|....*....|
gi 15217524 401 lqsggtvtsecqitPLKLILMSATLRVEDF 430
Cdd:cd17978 151 --------------PLKVIIMSATLDADLF 166
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
241-430 |
1.73e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 193.84 E-value: 1.73e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFgskqfSSRSGIIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGW-----TAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGE-NSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqk 399
Cdd:cd17980 76 GHEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGD------- 148
|
170 180 190
....*....|....*....|....*....|.
gi 15217524 400 slqsggtvtsecqitpLKLILMSATLRVEDF 430
Cdd:cd17980 149 ----------------LRLIVASATLDAEKF 163
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
241-834 |
2.58e-55 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 207.85 E-value: 2.58e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVP-QFLYEAGFgskqfssrSGIIGITQPRRVAVLATAKRVAFELGVR 319
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGI--------NGKIIMLEPRRLAARNVAQRLAEQLGEK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 320 LGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVikirqeyyeeqQK 399
Cdd:PRK11664 76 PGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDV-----------QQ 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 400 SLQSGgtvtsecqitpLKLILMSATLrveDFVSGKRLFPNiPPLIEVPTRQYPVTIHFskkteivdyigeaykKVMSIHK 479
Cdd:PRK11664 145 GLRDD-----------LKLLIMSATL---DNDRLQQLLPD-APVIVSEGRSFPVERRY---------------QPLPAHQ 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 480 KLPQ--------------GGILVFVTGQREVDYLCEKLrksskelvvqaakrdayvkkkcddgsfggvdmkeiAEAFDDD 545
Cdd:PRK11664 195 RFDEavarataellrqesGSLLLFLPGVGEIQRVQEQL-----------------------------------ASRVASD 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 546 snnqnsrfsshgedpsdigdgnydddfeeedmyesdedrdwetVDdgfassfveegkldalraafnaladkngsvsaepa 625
Cdd:PRK11664 240 -------------------------------------------VL----------------------------------- 241
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 626 ksiaaenqeaeqvknkfspgklrVLPLYAMLSPAAQLRVFEEVEKEERLVVVATNVAETSLTIPGIKYVVDTGRVKVKNY 705
Cdd:PRK11664 242 -----------------------LCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARF 298
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 706 DSKTGMESYEVDWISQASASQRAGRAGRTGPGHCYRLYSSAVFSNIfEESSLPEIMKVPVDGVILLMKSMNIPKVENFPF 785
Cdd:PRK11664 299 DPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERA-AAQSEPEILHSDLSGLLLELLQWGCHDPAQLSW 377
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 15217524 786 PTPPEPSAIREAERCLKALEALDSNGGLTPLGKAMSHYPMSPRHSRMLL 834
Cdd:PRK11664 378 LDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLV 426
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
241-441 |
2.51e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 187.37 E-value: 2.51e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFgskqfsSRSGIIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGF------SQHGMIGVTQPRRVAAISVAQRVAEEMKCTL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLtrvikirqeyyeeqQKS 400
Cdd:cd17984 75 GSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLL--------------KKL 140
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15217524 401 LQSGgtvtSECQITPLKLILMSATLRVEDFVSgkrLFPNIP 441
Cdd:cd17984 141 FQEK----SPNRKEHLKVVVMSATLELAKLSA---FFGNCP 174
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
451-743 |
4.04e-54 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 186.20 E-value: 4.04e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 451 YPVTIHFSK----------KTEIVDYIGEAYKKVMSIHKKLPQGGILVFVTGQREVDYLCEKLRKSSKElvvqaakrday 520
Cdd:cd18791 1 FPVEVYYLEdilellgissEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLS----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 521 vkkkcddgsfggvdmkeiaeafdddsnnqnsrfsshgedpsdigdgnydddfeeedmyesdedrdwetvddgfassfvee 600
Cdd:cd18791 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 601 gkldalraafnaladkngsvsaepaksiaaenqeaeqvknkFSPGKLRVLPLYAMLSPAAQLRVFEEVEKEERLVVVATN 680
Cdd:cd18791 70 -----------------------------------------PDLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATN 108
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15217524 681 VAETSLTIPGIKYVVDTGRVKVKNYDSKTGMESYEVDWISQASASQRAGRAGRTGPGHCYRLY 743
Cdd:cd18791 109 IAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
236-430 |
1.53e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 184.99 E-value: 1.53e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 236 ETRKDLPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKqfssrsGIIGITQPRRVAVLATAKRVAFE 315
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSR------GKIGCTQPRRVAAMSVAKRVAEE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 316 LGVRLGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyye 395
Cdd:cd17971 75 FGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPD--- 151
|
170 180 190
....*....|....*....|....*....|....*
gi 15217524 396 eqqkslqsggtvtsecqitpLKLILMSATLRVEDF 430
Cdd:cd17971 152 --------------------LKLIVTSATLDAVKF 166
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
241-441 |
1.54e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 184.59 E-value: 1.54e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFgskqfsSRSGIIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGY------TDYGMIGCTQPRRVAAMSVAKRVSEEMGVEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqks 400
Cdd:cd17983 75 GEEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRD-------- 146
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15217524 401 lqsggtvtsecqitpLKLILMSATLRVEDFVSgkrLFPNIP 441
Cdd:cd17983 147 ---------------LKLIVTSATMDADKFAD---FFGNVP 169
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
241-446 |
6.36e-53 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 183.04 E-value: 6.36e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKqfssrsGIIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIR------GLIGHTQPRRLAARSVAERIAEELKTEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqks 400
Cdd:cd17989 75 GGAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD-------- 146
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15217524 401 lqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNiPPLIEV 446
Cdd:cd17989 147 ---------------LKVIITSATIDAERF---SRHFNN-APIIEV 173
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
233-443 |
9.67e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 183.00 E-value: 9.67e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 233 EVEETRKDLPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKQFSSrsgiIGITQPRRVAVLATAKRV 312
Cdd:cd17973 5 EILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL----VACTQPRRVAAMSVAQRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 313 AFELGVRLGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQE 392
Cdd:cd17973 81 AEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 15217524 393 yyeeqqkslqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNIPPL 443
Cdd:cd17973 161 -----------------------LKLIVMSATLDAGKF---QKYFDNAPLL 185
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
241-430 |
1.23e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 173.46 E-value: 1.23e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFgskqfSSRSGIIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGY-----TKGGGKIGCTQPRRVAAMSVAARVAEEMGVKL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqks 400
Cdd:cd17974 76 GNEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPD-------- 147
|
170 180 190
....*....|....*....|....*....|
gi 15217524 401 lqsggtvtsecqitpLKLILMSATLRVEDF 430
Cdd:cd17974 148 ---------------LKLLISSATMDAEKF 162
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
241-446 |
1.83e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 173.01 E-value: 1.83e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSkqfssrsgiIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH---------IACTQPRRIACISLAKRVAFESLNQY 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqks 400
Cdd:cd17979 72 GSKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD-------- 143
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15217524 401 lqsggtvtsecqitpLKLILMSATLRVEDFVSgkrlFPNIPPLIEV 446
Cdd:cd17979 144 ---------------LKLILMSATINIELFSG----YFEGAPVVQV 170
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
241-430 |
3.33e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 149.61 E-value: 3.33e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLY----EAGFGSkqfSSRsgiIGITQPRRVAVLATAKRVAFEL 316
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILddaiERGKGS---SCR---IVCTQPRRISAISVAERVAAER 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 317 G--VRLGKEVGFQVRYD-KKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEy 393
Cdd:cd17981 75 AesCGLGNSTGYQIRLEsRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSD- 153
|
170 180 190
....*....|....*....|....*....|....*..
gi 15217524 394 yeeqqkslqsggtvtsecqitpLKLILMSATLRVEDF 430
Cdd:cd17981 154 ----------------------LKVILMSATLNAEKF 168
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
233-446 |
7.20e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 144.98 E-value: 7.20e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 233 EVEETRKDLPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKQFSSRSgiIGITQPRRVAVLATAKRV 312
Cdd:cd17972 51 QILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECN--IVVTQPRRISAVSVAERV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 313 AFELGVRLGKEVGFQVRYDKKIGE-NSSIKFMTDGILLREIQNDflLRRYSVIILDEAHERSLNTDILIGMLTRVIkirQ 391
Cdd:cd17972 129 AFERGEEVGKSCGYSVRFESVLPRpHASILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVV---Q 203
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 15217524 392 EYYEeqqkslqsggtvtsecqitpLKLILMSATLRVEDFvsgKRLFPNIpPLIEV 446
Cdd:cd17972 204 AYPD--------------------LRVILMSATIDTSMF---CEYFFNC-PVIEV 234
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
241-424 |
3.59e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 141.08 E-value: 3.59e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKQfSSRSGIIgITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGR-GARCNVV-ITQPRRISAVSVAQRVAHELGPNL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGEN-SSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqqk 399
Cdd:cd17976 79 RRNVGYQVRLESRPPPRgGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPE------- 151
|
170 180
....*....|....*....|....*
gi 15217524 400 slqsggtvtsecqitpLKLILMSAT 424
Cdd:cd17976 152 ----------------LRVVLMSAT 160
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
241-441 |
6.33e-38 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 140.16 E-value: 6.33e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVP-QFLYEAGFgskqfssRSGIIGITQPRRVAVLATAKRVAFELGVR 319
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPlALLAELWI-------AGGKIIVLEPRRVAARAAARRLATLLGEA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 320 LGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVikiRQEYYEEqqk 399
Cdd:cd17990 74 PGETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEV---QQLLRDD--- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15217524 400 slqsggtvtsecqitpLKLILMSATLRVEDFVsgkRLFPNIP 441
Cdd:cd17990 148 ----------------LRLLAMSATLDGDGLA---ALLPEAP 170
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
241-446 |
4.47e-36 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 134.94 E-value: 4.47e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKQFSSrsgiIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCN----IVVTQPRRIAAISIARRVSQEREWTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEYyeeqqks 400
Cdd:cd17988 77 GSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRH------- 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15217524 401 lqsggtvtsecqitpLKLILMSATLRVEDFVSGKRLFPNIPPLIEV 446
Cdd:cd17988 150 ---------------VKIILMSATISCKEFADYFTTPNNPAYVFEV 180
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
241-432 |
3.10e-34 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 130.03 E-value: 3.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFGSKQFSSRSGIIgITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQKCNIV-CTQPRRISAMSLATRVCEELGCES 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 321 G-----KEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyye 395
Cdd:cd17975 80 GpggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSD--- 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 15217524 396 eqqkslqsggtvtsecqitpLKLILMSATLRVEDFVS 432
Cdd:cd17975 157 --------------------LHLILMSATVDCEKFSS 173
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
241-430 |
3.91e-34 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 129.19 E-value: 3.91e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFgskqFSSRSGIIGI--TQPRRVAVLATAKRVAFELGV 318
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSL----QGPPLPVANIicTQPRRISAISVAERVAQERAE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 319 RLGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEyyeeqq 398
Cdd:cd17985 77 RVGQSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPD------ 150
|
170 180 190
....*....|....*....|....*....|..
gi 15217524 399 kslqsggtvtsecqitpLKLILMSATLRVEDF 430
Cdd:cd17985 151 -----------------LKVILMSATLNAELF 165
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
241-441 |
1.47e-31 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 121.86 E-value: 1.47e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAgfgskqfSSRSGI---IGITQPRRVAVLATAKRVAFELG 317
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDD-------CYANGIpcrIFCTQPRRLAAIAVAERVAAERG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 318 VRLGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQN-DFLLRRYSVIILDEAHERSLNTDILigmLTRVIKIRQEYyee 396
Cdd:cd17987 74 EKIGQTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFL---LTKLRDILQKH--- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15217524 397 qqkslqsggtvtsecqiTPLKLILMSATLRVEDFVsgkRLFPNIP 441
Cdd:cd17987 148 -----------------PNLKLILSSAALDVNLFI---RYFGSCP 172
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
241-393 |
2.39e-28 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 112.68 E-value: 2.39e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPA-VIISGQTGCGKTTQVPQFLYEAGFgSKQFSSrsGIIGITQPRRVAVLATAKRVAFELGVR 319
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGiVLVSGEPGSGKSTQVPQWCAEFAL-SRGFQK--GQVTVTQPHPLAARSLALRVADEMDLN 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15217524 320 LGKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQEY 393
Cdd:cd17986 78 LGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPEL 151
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
241-392 |
5.57e-27 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 108.76 E-value: 5.57e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 241 LPIVMMEQEIMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGFgSKQFssRSGIIGITQPRRVAVLATAKRVAFELGVRL 320
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCL-SAHY--QHGVVVCTQVHKQTAVWLALRVADEMDVNI 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15217524 321 GKEVGFQVRYDKKIGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHERSLNTDILIGMLTRVIKIRQE 392
Cdd:cd17977 78 GHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPE 149
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
250-456 |
4.50e-20 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 89.86 E-value: 4.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 250 IMEAINRHPAVIISGQTGCGKTTQVPQFLYEAGfgskqFSSRSGIIGITQPRRVAVLATAKRVAFELGVRLGKEVGFQVR 329
Cdd:smart00487 17 IEALLSGLRDVILAAPTGSGKTLAALLPALEAL-----KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 330 YDKK------IGENSSIKFMTDGILLREIQNDFL-LRRYSVIILDEAHERS--LNTDILIGMLTRVIKIRQeyyeeqqks 400
Cdd:smart00487 92 DSKReqlrklESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNVQ--------- 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 15217524 401 lqsggtvtsecqitplkLILMSATLRVEDFVSGKRLFPNIPPLIEVPTRQYPVTIH 456
Cdd:smart00487 163 -----------------LLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1011-1085 |
5.52e-19 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 82.69 E-value: 5.52e-19
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15217524 1011 AICAGWADRVARKTRAT-EYQACAVQEPVFLHRWSSLIN---SAPELLVYSELLLTNRPYMHGATRVRPEWLVKHAKSL 1085
Cdd:pfam07717 4 ALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNektFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAPHI 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
797-920 |
3.91e-18 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 80.74 E-value: 3.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 797 AERCLKALEALDSNGGLTPLGKAMSHYPMSPRHSRMLLTVIQM--LKETrnysranLILgyavaaVAALSLPNPLIMEFE 874
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELgcLDEV-------LTI------VAALSVRDPFVQPNF 67
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 15217524 875 GEKKNESKDADKtvkqedKQRKKDRKEKIKAARDRFsnpSSDALTV 920
Cdd:pfam04408 68 LDPRSAAKAARR------RRRAADEKARAKFARLDL---EGDHLTL 104
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
636-735 |
3.08e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 69.16 E-value: 3.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 636 EQVKNKFSPGKLRVLPLYAMLSPAAQLRVFEEVEKEERLVVVATNVAETSLTIPGIKYVVdtgrvkvkNYDSktgmesye 715
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVI--------IYDL-------- 64
|
90 100
....*....|....*....|
gi 15217524 716 vdWISQASASQRAGRAGRTG 735
Cdd:smart00490 65 --PWSPASYIQRIGRAGRAG 82
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
646-735 |
2.66e-12 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 64.54 E-value: 2.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 646 KLRVLPLYAMLSPAAQLRVFEEVEKEERLVVVATNVAETSLTIPGIKYVVdtgrvkvkNYDSKTGMESYEvdwisqasas 725
Cdd:pfam00271 38 GIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVI--------NYDLPWNPASYI---------- 99
|
90
....*....|
gi 15217524 726 QRAGRAGRTG 735
Cdd:pfam00271 100 QRIGRAGRAG 109
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
803-919 |
1.44e-11 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 61.52 E-value: 1.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 803 ALEALDSNGGLTPLGKAMSHYPMSPRHSRMLLTVIQMlketrNYSRANLILgyavaaVAALSLPNPlimefegekknesk 882
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEF-----GCLDEILTI------VAMLSVGDP-------------- 55
|
90 100 110
....*....|....*....|....*....|....*..
gi 15217524 883 dadktvkqedkqRKKDRKEKIKAARDRFSNPSSDALT 919
Cdd:smart00847 56 ------------RPKEKREDADAARRRFADPESDHLT 80
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
246-490 |
4.26e-08 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 57.68 E-value: 4.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 246 MEQEIMEAINRHPAVIISGQTGCGKTTQVPQFL--YEAGFG--------SKQFSSRSgiIGITQPRRVAVLATAKRVAFE 315
Cdd:PHA02653 168 VQLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLlwFNYLFGgfdnldkiDPNFIERP--IVLSLPRVALVRLHSITLLKS 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 316 LGvrlgkevgfqvrYDKKIGENSSIKF--MTDGILLREIQNDFL-----------LRRYSVIILDEAHERSLNTDILIGM 382
Cdd:PHA02653 246 LG------------FDEIDGSPISLKYgsIPDELINTNPKPYGLvfsthkltlnkLFDYGTVIIDEVHEHDQIGDIIIAV 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 383 LTR-VIKIRQeyyeeqqkslqsggtvtsecqitplkLILMSATL-----RVEDFvsgkrlFPNIPPL-IEVPTRqYPVT- 454
Cdd:PHA02653 314 ARKhIDKIRS--------------------------LFLMTATLeddrdRIKEF------FPNPAFVhIPGGTL-FPISe 360
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 15217524 455 IHFSKKTEIVD---YIGEAYKKVMSIHKKL--PQG--GIlVFV 490
Cdd:PHA02653 361 VYVKNKYNPKNkraYIEEEKKNIVTALKKYtpPKGssGI-VFV 402
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
257-424 |
1.25e-07 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 52.02 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 257 HPAVIISGQTGCGKTTQVPQFLYEAgfgskqfssrsgiiGITQPRRVAVL----ATAKRVAFELGVRLGKEVGFQVRYD- 331
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLL--------------LLKKGKKVLVLvptkALALQTAERLRELFGPGIRVAVLVGg 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 332 -------KKIGENSSIKFMTDGILLREIQND--FLLRRYSVIILDEAHERSLNTDiligmltrviKIRQEYYEEQQKSLq 402
Cdd:cd00046 67 ssaeereKNKLGDADIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSR----------GALILDLAVRKAGL- 135
|
170 180
....*....|....*....|..
gi 15217524 403 sggtvtsecqiTPLKLILMSAT 424
Cdd:cd00046 136 -----------KNAQVILLSAT 146
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
664-744 |
3.53e-06 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 51.52 E-value: 3.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 664 VFEEVEKEERL-VVVATNVAETSLTIPGIKYVVDTGRVKVKNYdsKTGMESYevdwISQASASQRAGRAGRTGPGHCYRL 742
Cdd:PHA02653 437 ILEKVYSSKNPsIIISTPYLESSVTIRNATHVYDTGRVYVPEP--FGGKEMF----ISKSMRTQRKGRVGRVSPGTYVYF 510
|
..
gi 15217524 743 YS 744
Cdd:PHA02653 511 YD 512
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
260-425 |
3.57e-06 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 48.39 E-value: 3.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 260 VIISGQTGCGKTT--QVPqfLYEAGfgSKQFSSRSGIIgITqPRRV---AVLATAKRVAFELGVRLGKEV-GFQVRYDKK 333
Cdd:pfam00270 17 VLVQAPTGSGKTLafLLP--ALEAL--DKLDNGPQALV-LA-PTRElaeQIYEELKKLGKGLGLKVASLLgGDSRKEQLE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 334 IGENSSIKFMTDGILLREIQNDFLLRRYSVIILDEAHErslntdiligMLTRVikiRQEYYEEQQKSLQsggtvtSECQI 413
Cdd:pfam00270 91 KLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR----------LLDMG---FGPDLEEILRRLP------KKRQI 151
|
170
....*....|..
gi 15217524 414 tplklILMSATL 425
Cdd:pfam00270 152 -----LLLSATL 158
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
675-736 |
3.31e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 43.08 E-value: 3.31e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15217524 675 VVVATNVAETSLTIPGIKYVVDTGRvkvknydsktgmesyevdWISQASASQRAGRAGRTGP 736
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDP------------------PSSAASYIQRVGRAGRGGK 68
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
245-473 |
7.25e-05 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 47.00 E-value: 7.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 245 MMEQEIMEAINRHPAVIISGQTGCGKTtqvpqflyEAGFG-----SKQFSSRSGIIGItqPRRVAVLATAKRV--AFELG 317
Cdd:COG1203 135 ALELALEAAEEEPGLFILTAPTGGGKT--------EAALLfalrlAAKHGGRRIIYAL--PFTSIINQTYDRLrdLFGED 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 318 VRL------------GKEVGFQVRYDKKIGEN--SSIKFMT-----DGILLReiQNDFLLRR----YSVIILDEAHerSL 374
Cdd:COG1203 205 VLLhhsladldlleeEEEYESEARWLKLLKELwdAPVVVTTidqlfESLFSN--RKGQERRLhnlaNSVIILDEVQ--AY 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 375 NTDILiGMLTRVIKIRQEYyeeqqkslqsGGTVtsecqitplklILMSATL---RVEDFVSGKRLFPNIPPLIEVPTRQY 451
Cdd:COG1203 281 PPYML-ALLLRLLEWLKNL----------GGSV-----------ILMTATLpplLREELLEAYELIPDEPEELPEYFRAF 338
|
250 260
....*....|....*....|....*..
gi 15217524 452 P---VTIHFSKKT--EIVDYIGEAYKK 473
Cdd:COG1203 339 VrkrVELKEGPLSdeELAELILEALHK 365
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
633-740 |
1.04e-03 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 40.57 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 633 QEAEQVKNKFSPGKLRVLPLYAMLSPAAQLRVFEEVEKEERLVVVATNVAETSLTIPGIKYVVdtgrvkvkNYDSKTGME 712
Cdd:cd18787 38 KRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRVLVATDVAARGLDIPGVDHVI--------NYDLPRDAE 109
|
90 100
....*....|....*....|....*....
gi 15217524 713 SYevdwisqasaSQRAGRAGRTG-PGHCY 740
Cdd:cd18787 110 DY----------VHRIGRTGRAGrKGTAI 128
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
266-370 |
1.12e-03 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 41.00 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 266 TGCGKTTQV-PQFLYEAgfgskqfssrsgiigITQPRRVAVLATAKRVAFELGVRLGKEvgfQVRYdkKIGE-------N 337
Cdd:cd17931 10 PGAGKTTRVlPQIIREA---------------IKKRLRTLVLAPTRVVAAEMYEALRGL---PIRY--RTGAvkeehggN 69
|
90 100 110
....*....|....*....|....*....|...
gi 15217524 338 SSIKFMTDGILLREIQNDFLLRRYSVIILDEAH 370
Cdd:cd17931 70 EIVDYMCHGTFTCRLLSPKRVPNYNLIIMDEAH 102
|
|
| ExeA |
COG3267 |
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ... |
248-402 |
4.19e-03 |
|
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];
Pssm-ID: 442498 [Multi-domain] Cd Length: 261 Bit Score: 40.54 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 248 QEIMEAINRHPAVI-ISGQTGCGKTTQVPQFLyeagfgsKQFSSRSGIIGITQPrRVAVLATAKRVAFELGVRLgkevgf 326
Cdd:COG3267 33 ARLEYALAQGGGFVvLTGEVGTGKTTLLRRLL-------ERLPDDVKVAYIPNP-QLSPAELLRAIADELGLEP------ 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15217524 327 qvrydkkigenssiKFMTDGILLREIQnDFLLRRYS-----VIILDEAHerSLNTDIL--IGMLTrvikirqEYYEEQQK 399
Cdd:COG3267 99 --------------KGASKADLLRQLQ-EFLLELAAagrrvVLIIDEAQ--NLPPETLeeLRLLS-------NLETDSRK 154
|
...
gi 15217524 400 SLQ 402
Cdd:COG3267 155 LLQ 157
|
|
| |
