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Conserved domains on  [gi|42562487|ref|NP_174606|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 374-550 1.47e-18

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd10536:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 218  Bit Score: 85.04  E-value: 1.47e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 374 TDLSNLQEILEL-SHTySKMNPENKLELHLLSIVLIWCLSKSSCPNLSVCEASVTQTI-------ILLS---QIKVNSIA 442
Cdd:cd10536  44 PYSSDYRSVYNLvTHT-ENRSPEDLFQRALTAVFLAKCLQLSGYFLLWEASTELNGEEpesilggLLLRhlqQLQCNAHA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 443 VARMKSSgdsfkclpsgniSTKEPIQSLEQIRVGQALYKTGSLFNHSCKPNIHLYFLSRGLIMQTTEFVPTGCPLELSYG 522
Cdd:cd10536 123 ITELQTT------------SSGSQVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYG 190

                       170       180
                ....*....|....*....|....*...
gi 42562487 523 PEVGKWDCKNRIRFLEEEYFFHCRCRGC 550
Cdd:cd10536 191 PHFSRMKRSERQRLLKEQYFFDCSCEAC 218
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-170 1.83e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 76.97  E-value: 1.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  66 LKRRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYR 145
Cdd:COG0457  45 LYNLGLAYLRLGRYEEALADYEQALELDPDDA---------EALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                        90       100
                ....*....|....*....|....*
gi 42562487 146 RGKLNTLLGNYKDAFRDITVSMSLE 170
Cdd:COG0457 116 LGLALLELGRYDEAIEAYERALELD 140
TPR_12 pfam13424
Tetratricopeptide repeat;
693-769 5.58e-05

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 5.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562487   693 DIADAEDKVAQACYLAGELVDARKHCEASIKILKRLYEDEHVVIGNEMVKLASIQLASGDSSGAWDTTKRSSQIFSK 769
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
zf-MYND super family cl46589
MYND finger;
263-291 5.97e-03

MYND finger;


The actual alignment was detected with superfamily member pfam01753:

Pssm-ID: 480929  Cd Length: 39  Bit Score: 35.09  E-value: 5.97e-03
                          10        20
                  ....*....|....*....|....*....
gi 42562487   263 CHFCLNElPADTVPCPSCSIPVYCSESCQ 291
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQ 28
 
Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 374-550 1.47e-18

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 85.04  E-value: 1.47e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 374 TDLSNLQEILEL-SHTySKMNPENKLELHLLSIVLIWCLSKSSCPNLSVCEASVTQTI-------ILLS---QIKVNSIA 442
Cdd:cd10536  44 PYSSDYRSVYNLvTHT-ENRSPEDLFQRALTAVFLAKCLQLSGYFLLWEASTELNGEEpesilggLLLRhlqQLQCNAHA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 443 VARMKSSgdsfkclpsgniSTKEPIQSLEQIRVGQALYKTGSLFNHSCKPNIHLYFLSRGLIMQTTEFVPTGCPLELSYG 522
Cdd:cd10536 123 ITELQTT------------SSGSQVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYG 190

                       170       180
                ....*....|....*....|....*...
gi 42562487 523 PEVGKWDCKNRIRFLEEEYFFHCRCRGC 550
Cdd:cd10536 191 PHFSRMKRSERQRLLKEQYFFDCSCEAC 218
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-170 1.83e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 76.97  E-value: 1.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  66 LKRRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYR 145
Cdd:COG0457  45 LYNLGLAYLRLGRYEEALADYEQALELDPDDA---------EALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                        90       100
                ....*....|....*....|....*
gi 42562487 146 RGKLNTLLGNYKDAFRDITVSMSLE 170
Cdd:COG0457 116 LGLALLELGRYDEAIEAYERALELD 140
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 60-186 6.28e-14

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 75.41  E-value: 6.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487    60 EETSLDLKRRGNHCFRSRDFDEALRLYSKALRVAPlDAIdgdksllasLFLNRANVLHNLGLLKESLRDCHRALRIDPYY 139
Cdd:TIGR00990 124 KKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKP-DPV---------YYSNRAACHNALGDWEKVVEDTTAALELDPDY 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 42562487   140 AKAWYRRGKLNTLLGNYKDAFRDITVS------------MSLESSLvgKKQLQNELKAI 186
Cdd:TIGR00990 194 SKALNRRANAYDGLGKYADALLDLTASciidgfrneqsaQAVERLL--KKFAESKAKEI 250
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 65-172 1.37e-07

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 54.41  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487   65 DLKRRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWY 144
Cdd:PLN03088   4 DLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNA---------ELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYL 74

                         90       100
                 ....*....|....*....|....*...
gi 42562487  145 RRGKLNTLLGNYKDAFRDITVSMSLESS 172
Cdd:PLN03088  75 RKGTACMKLEEYQTAKAALEKGASLAPG 102
TPR_12 pfam13424
Tetratricopeptide repeat;
66-142 5.47e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 5.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562487    66 LKRRGNHCFRSRDFDEALRLYSKALRVAplDAIDGDKSllaslfLNRANVLHNLGLLKESLRDCHRALRidpYYAKA 142
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIA--RRLLGPDH------PLTATTLLNLGRLYLELGRYEEALE---LLERA 71
TPR_12 pfam13424
Tetratricopeptide repeat;
693-769 5.58e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 5.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562487   693 DIADAEDKVAQACYLAGELVDARKHCEASIKILKRLYEDEHVVIGNEMVKLASIQLASGDSSGAWDTTKRSSQIFSK 769
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 106-137 2.75e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.89  E-value: 2.75e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 42562487    106 ASLFLNRANVLHNLGLLKESLRDCHRALRIDP 137
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDP 32
zf-MYND pfam01753
MYND finger;
263-291 5.97e-03

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 35.09  E-value: 5.97e-03
                          10        20
                  ....*....|....*....|....*....
gi 42562487   263 CHFCLNElPADTVPCPSCSIPVYCSESCQ 291
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQ 28
 
Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 374-550 1.47e-18

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 85.04  E-value: 1.47e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 374 TDLSNLQEILEL-SHTySKMNPENKLELHLLSIVLIWCLSKSSCPNLSVCEASVTQTI-------ILLS---QIKVNSIA 442
Cdd:cd10536  44 PYSSDYRSVYNLvTHT-ENRSPEDLFQRALTAVFLAKCLQLSGYFLLWEASTELNGEEpesilggLLLRhlqQLQCNAHA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 443 VARMKSSgdsfkclpsgniSTKEPIQSLEQIRVGQALYKTGSLFNHSCKPNIHLYFLSRGLIMQTTEFVPTGCPLELSYG 522
Cdd:cd10536 123 ITELQTT------------SSGSQVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYG 190

                       170       180
                ....*....|....*....|....*...
gi 42562487 523 PEVGKWDCKNRIRFLEEEYFFHCRCRGC 550
Cdd:cd10536 191 PHFSRMKRSERQRLLKEQYFFDCSCEAC 218
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-170 1.83e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 76.97  E-value: 1.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  66 LKRRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYR 145
Cdd:COG0457  45 LYNLGLAYLRLGRYEEALADYEQALELDPDDA---------EALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                        90       100
                ....*....|....*....|....*
gi 42562487 146 RGKLNTLLGNYKDAFRDITVSMSLE 170
Cdd:COG0457 116 LGLALLELGRYDEAIEAYERALELD 140
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 474-550 8.78e-15

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 71.25  E-value: 8.78e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42562487 474 RVGQALYKTGSLFNHSCKPNIHLYFLSRG-LIMQTTEFVPTGCPLELSYGPEVgkWDCKNRIRFLEEEYFFHCRCRGC 550
Cdd:cd20071  47 EIGVGLFPLASLLNHSCDPNAVVVFDGNGtLRVRALRDIKAGEELTISYIDPL--LPRTERRRELLEKYGFTCSCPRC 122
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-162 2.40e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.50  E-value: 2.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  66 LKRRGNHCFRSRDFDEALRLYSKALRVAPLDAIdgdksllasLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYR 145
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAE---------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                        90
                ....*....|....*..
gi 42562487 146 RGKLNTLLGNYKDAFRD 162
Cdd:COG0457  82 LGLALQALGRYEEALED 98
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-163 4.58e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 72.73  E-value: 4.58e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  66 LKRRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYR 145
Cdd:COG0457  79 LNNLGLALQALGRYEEALEDYDKALELDPDDA---------EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                        90
                ....*....|....*...
gi 42562487 146 RGKLNTLLGNYKDAFRDI 163
Cdd:COG0457 150 LGIALEKLGRYEEALELL 167
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 60-186 6.28e-14

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 75.41  E-value: 6.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487    60 EETSLDLKRRGNHCFRSRDFDEALRLYSKALRVAPlDAIdgdksllasLFLNRANVLHNLGLLKESLRDCHRALRIDPYY 139
Cdd:TIGR00990 124 KKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKP-DPV---------YYSNRAACHNALGDWEKVVEDTTAALELDPDY 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 42562487   140 AKAWYRRGKLNTLLGNYKDAFRDITVS------------MSLESSLvgKKQLQNELKAI 186
Cdd:TIGR00990 194 SKALNRRANAYDGLGKYADALLDLTASciidgfrneqsaQAVERLL--KKFAESKAKEI 250
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
66-169 5.62e-12

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 66.09  E-value: 5.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  66 LKRRGNHCFRSRDFDEALRLYSKALRVAPLdaidgdkslLASLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYR 145
Cdd:COG4785  76 YYERGVAYDSLGDYDLAIADFDQALELDPD---------LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                        90       100
                ....*....|....*....|....
gi 42562487 146 RGKLNTLLGNYKDAFRDITVSMSL 169
Cdd:COG4785 147 RGIALYYLGRYELAIADLEKALEL 170
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
74-173 1.94e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 60.95  E-value: 1.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  74 FRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRdCHRALRIDPYYAKAWYRRGKLNTLL 153
Cdd:COG3063   3 LKLGDLEEAEEYYEKALELDPDNA---------DALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLEL 72

                        90       100
                ....*....|....*....|
gi 42562487 154 GNYKDAFRDITVSMSLESSL 173
Cdd:COG3063  73 GDYDEALAYLERALELDPSA 92
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 68-161 3.90e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 61.36  E-value: 3.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  68 RRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRG 147
Cdd:COG4783   9 ALAQALLLAGDYDEAEALLEKALELDPDNP---------EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLG 79

                        90
                ....*....|....
gi 42562487 148 KLNTLLGNYKDAFR 161
Cdd:COG4783  80 LALLKAGDYDEALA 93
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
105-164 8.68e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 62.63  E-value: 8.68e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 105 LASLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLLGNYKDAFRDIT 164
Cdd:COG4785  72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFD 131
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 74-163 1.62e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 60.36  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  74 FRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLL 153
Cdd:COG5010  65 NKLGDFEESLALLEQALQLDPNNP---------ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL 135

                        90
                ....*....|
gi 42562487 154 GNYKDAFRDI 163
Cdd:COG5010 136 GQDDEAKAAL 145
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 65-161 6.06e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 62.70  E-value: 6.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  65 DLKRRGNHCFRSRDFDEALRLYSKALRVAPLDAIdgdksllasLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWY 144
Cdd:COG3914  80 LLELAALLLQALGRYEEALALYRRALALNPDNAE---------ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYL 150

                        90
                ....*....|....*..
gi 42562487 145 RRGKLNTLLGNYKDAFR 161
Cdd:COG3914 151 NLGEALRRLGRLEEAIA 167
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 70-159 2.24e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.78  E-value: 2.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  70 GNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKL 149
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALALNPDFA---------EAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189

                        90
                ....*....|
gi 42562487 150 NTLLGNYKDA 159
Cdd:COG3914 190 LQDLGRLEEA 199
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 69-159 2.45e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 56.35  E-value: 2.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  69 RGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGK 148
Cdd:COG4783  44 LGEILLQLGDLDEAIVLLHEALELDPDEP---------EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLAR 114

                        90
                ....*....|.
gi 42562487 149 LNTLLGNYKDA 159
Cdd:COG4783 115 AYRALGRPDEA 125
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 70-161 2.77e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.78  E-value: 2.77e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  70 GNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKL 149
Cdd:COG4235  24 GRAYLRLGRYDEALAAYEKALRLDPDNA---------DALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLA 94

                        90
                ....*....|..
gi 42562487 150 NTLLGNYKDAFR 161
Cdd:COG4235  95 AFQQGDYAEAIA 106
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-162 8.69e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 8.69e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42562487 105 LASLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLLGNYKDAFRD 162
Cdd:COG0457   7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALAD 64
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 358-550 5.16e-08

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 53.91  E-value: 5.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 358 LAGRIIMKLinQGKAATDLSNLQEILELSHTYSKMNPENKLELHLLSIVLIWCLSKSscpnlsVCEASVTQTII----LL 433
Cdd:cd19203  46 LEGRIIFKL--LDKAPSESEKLYSFYDLQSNINKLSEDRKEGLRQLAMVLQHYLREE------IQDASQLPPAFdifeLF 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487 434 SQIKVNSIAV--ARMKSsgdsfkclpsgnistkepiqsleqirVGQALYKTGSLFNHSCKPNIHLYFLSRGLIMQTTEFV 511
Cdd:cd19203 118 AKVTCNSFTIcdAEMQE--------------------------VGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIREI 171

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 42562487 512 PTGCPLELSYGPEVGKWDckNRIRFLEEEYFFHCRCRGC 550
Cdd:cd19203 172 EVGEELTISYIDMLMPSE--ERRKQLRDQYCFECDCFRC 208
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 65-172 1.37e-07

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 54.41  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487   65 DLKRRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWY 144
Cdd:PLN03088   4 DLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNA---------ELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYL 74

                         90       100
                 ....*....|....*....|....*...
gi 42562487  145 RRGKLNTLLGNYKDAFRDITVSMSLESS 172
Cdd:PLN03088  75 RKGTACMKLEEYQTAKAALEKGASLAPG 102
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
69-164 5.70e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.07  E-value: 5.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  69 RGNHCFRSRDFDEALRLYSKALRVAPLDAIDgdksllaslFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGk 148
Cdd:COG4785 113 RGLAYLLLGDYDAALEDFDRALELDPDYAYA---------YLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLY- 182

                        90
                ....*....|....*.
gi 42562487 149 LNTLLGNYKDAFRDIT 164
Cdd:COG4785 183 LAERKLDPEKALALLL 198
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 66-159 6.88e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 6.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  66 LKRRGNHCFRSRDFDEALRLYSKALRVAPLDAIdgdksllasLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYR 145
Cdd:COG2956 113 LRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH---------AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLL 183

                        90
                ....*....|....
gi 42562487 146 RGKLNTLLGNYKDA 159
Cdd:COG2956 184 LAELYLEQGDYEEA 197
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 81-159 8.57e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 8.57e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42562487  81 EALRLYSKALRVAPLDAIDGDKSLLASLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLLGNYKDA 159
Cdd:COG5010  29 AALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEA 107
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 68-146 8.93e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.22  E-value: 8.93e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42562487  68 RRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRR 146
Cdd:COG3914 151 NLGEALRRLGRLEEAIAALRRALELDPDNA---------EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 40-194 1.63e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487    40 QFHQAVSELANPELGccgKNEETSLDLKRRGNHCFRSRDFDEALRLYSKALRVAPldaidgdKSLLASLFLnrANVLHNL 119
Cdd:TIGR02917 105 KFQQVLDELPGKTLL---DDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDP-------RSLYAKLGL--AQLALAE 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487   120 GLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLLGNYKDA-----------FRDITVSMSLESSLVGKKQLQ-------- 180
Cdd:TIGR02917 173 NRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELAlaayrkaialrPNNIAVLLALATILIEAGEFEeaekhada 252

                         170       180
                  ....*....|....*....|....*
gi 42562487   181 -----------NELKAIPDYQNNQT 194
Cdd:TIGR02917 253 llkkapnsplaHYLKALVDFQKKNY 277
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 74-161 1.92e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 1.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  74 FRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLL 153
Cdd:COG2956 155 LEQGDYDEAIEALEKALKLDPDCA---------RALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKL 225


                ....*...
gi 42562487 154 GNYKDAFR 161
Cdd:COG2956 226 GDPEEALE 233
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 475-550 4.79e-05

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 45.11  E-value: 4.79e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42562487 475 VGQALYKTGSLFNHSCKPNIHLYFLSRGLIMQTTEFVPTGCPLELSYGPEVGKWDckNRIRFLEEEYFFHCRCRGC 550
Cdd:cd19167 130 VGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSYIDLLYPTE--ERRDQLRDQYFFLCQCADC 203
TPR_12 pfam13424
Tetratricopeptide repeat;
66-142 5.47e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 5.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562487    66 LKRRGNHCFRSRDFDEALRLYSKALRVAplDAIDGDKSllaslfLNRANVLHNLGLLKESLRDCHRALRidpYYAKA 142
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIA--RRLLGPDH------PLTATTLLNLGRLYLELGRYEEALE---LLERA 71
TPR_12 pfam13424
Tetratricopeptide repeat;
693-769 5.58e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 5.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562487   693 DIADAEDKVAQACYLAGELVDARKHCEASIKILKRLYEDEHVVIGNEMVKLASIQLASGDSSGAWDTTKRSSQIFSK 769
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
COG3899 COG3899
Predicted ATPase [General function prediction only];
70-169 6.13e-05

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 46.78  E-value: 6.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487   70 GNHCFRSRDFDEALRLYSKALRVAPLDAidgDKSLLASLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKL 149
Cdd:COG3899  712 ARRALARGAYAEALRYLERALELLPPDP---EEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNP 788

                         90       100       110
                 ....*....|....*....|....*....|.
gi 42562487  150 NT-----------LLGNYKDAFRDITVSMSL 169
Cdd:COG3899  789 PAsarayanlgllLLGDYEEAYEFGELALAL 819
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 41-137 1.85e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 1.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  41 FHQAVSelANPElgccgkNEETSLDLkrrGNHCFRSRDFDEALRLYSKALRVAPLDaidgdksllASLFLNRANVLHNLG 120
Cdd:COG4783  61 LHEALE--LDPD------EPEARLNL---GLALLKAGDYDEALALLEKALKLDPEH---------PEAYLRLARAYRALG 120

                        90
                ....*....|....*..
gi 42562487 121 LLKESLRDCHRALRIDP 137
Cdd:COG4783 121 RPDEAIAALEKALELDP 137
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 52-174 2.40e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.59  E-value: 2.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487    52 ELGCCGKNEETSLDLkrRGNHCFRSRDFDEALRLYSKALRVAPLdaidgdkslLASLFLNRANVLHNLGLLKESLRDCHR 131
Cdd:TIGR00990 322 DLGKLGEKEAIALNL--RGTFKCLKGKHLEALADLSKSIELDPR---------VTQSYIKRASMNLELGDPDKAEEDFDK 390

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 42562487   132 ALRIDPYYAKAWYRRGKLNTLLGNYKDAFRDITVSMSLESSLV 174
Cdd:TIGR00990 391 ALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFI 433
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
115-159 3.82e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 3.82e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 42562487 115 VLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLLGNYKDA 159
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA 45
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 69-137 6.16e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 6.16e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42562487  69 RGNHCFRSRDFDEALRLYSKALRVAPLDaidgdksllASLFLNRANVLHNLGLLKESLRDCHRALRIDP 137
Cdd:COG5010  94 LALLYSRSGDKDEAKEYYEKALALSPDN---------PNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 106-170 6.48e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 6.48e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42562487 106 ASLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLLGNYKDAFRDITVSMSLE 170
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD 68
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 72-159 9.26e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 9.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  72 HCFRSR-DFDEALRLYSKALRVAPldaidgdKSLLASLFLnrANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLN 150
Cdd:COG2956  50 NLYRRRgEYDRAIRIHQKLLERDP-------DRAEALLEL--AQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIY 120


                ....*....
gi 42562487 151 TLLGNYKDA 159
Cdd:COG2956 121 EQEGDWEKA 129
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 74-159 1.08e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.59  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  74 FRSRDFDEALRLYSKALRVAPldaidgDKSLLASLFLNRANVLHNLGLLKESLRDCHRALRIDP---YYAKAWYRRGKLN 150
Cdd:COG1729   4 LKAGDYDEAIAAFKAFLKRYP------NSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPdspKAPDALLKLGLSY 77


                ....*....
gi 42562487 151 TLLGNYKDA 159
Cdd:COG1729  78 LELGDYDKA 86
TPR_1 pfam00515
Tetratricopeptide repeat;
106-139 1.16e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.02  E-value: 1.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 42562487   106 ASLFLNRANVLHNLGLLKESLRDCHRALRIDPYY 139
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 69-159 1.26e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  69 RGNHCFRSRDFDEALRLYSKALRVAP--LDAidgdKSLLASLFLNRanvlhnlGLLKESLRDCHRALRIDPYYAKAWYRR 146
Cdd:COG2956  14 KGLNYLLNGQPDKAIDLLEEALELDPetVEA----HLALGNLYRRR-------GEYDRAIRIHQKLLERDPDRAEALLEL 82

                        90
                ....*....|...
gi 42562487 147 GKLNTLLGNYKDA 159
Cdd:COG2956  83 AQDYLKAGLLDRA 95
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 66-94 1.27e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 36.73  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*....
gi 42562487    66 LKRRGNHCFRSRDFDEALRLYSKALRVAP 94
Cdd:pfam07719   4 LYNLGLAYYKLGDYEEALEAYEKALELDP 32
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 74-161 1.37e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  74 FRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYRRGKLNTLL 153
Cdd:COG2956  87 LKAGLLDRAEELLEKLLELDPDDA---------EALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQ 157


                ....*...
gi 42562487 154 GNYKDAFR 161
Cdd:COG2956 158 GDYDEAIE 165
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 68-140 1.39e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 37.70  E-value: 1.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42562487    68 RRGNHCFRSRDFDEALRLYSKALRVapldaiDGDKSLLASLFLNRANVLHNLGLLKESLRDCHRALRIDPYYA 140
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALAR------FPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGDP 68
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 106-137 2.75e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.89  E-value: 2.75e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 42562487    106 ASLFLNRANVLHNLGLLKESLRDCHRALRIDP 137
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDP 32
TPR_1 pfam00515
Tetratricopeptide repeat;
66-94 3.62e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.47  E-value: 3.62e-03
                          10        20
                  ....*....|....*....|....*....
gi 42562487    66 LKRRGNHCFRSRDFDEALRLYSKALRVAP 94
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNP 32
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-159 4.11e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 4.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562487  66 LKRRGNHCFRSRDFDEALRLYSKALRVAPLDAidgdksllaSLFLNRANVLHNLGLLKESLRDCHRALRIDPYYAKAWYR 145
Cdd:COG0457 113 LYNLGLALLELGRYDEAIEAYERALELDPDDA---------DALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAAL 183

                        90
                ....*....|....
gi 42562487 146 RGKLNTLLGNYKDA 159
Cdd:COG0457 184 GEAALALAAAEVLL 197
zf-MYND pfam01753
MYND finger;
263-291 5.97e-03

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 35.09  E-value: 5.97e-03
                          10        20
                  ....*....|....*....|....*....
gi 42562487   263 CHFCLNElPADTVPCPSCSIPVYCSESCQ 291
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQ 28
TPR_12 pfam13424
Tetratricopeptide repeat;
104-159 9.63e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.83  E-value: 9.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42562487   104 LLASLFLNRANVLHNLGLLKESLRDCHRALRI--------DPYYAKAWYRRGKLNTLLGNYKDA 159
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEA 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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