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Conserved domains on  [gi|15221135|ref|NP_174877|]
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Translation initiation factor IF2/IF5 [Arabidopsis thaliana]

Protein Classification

eukaryotic translation initiation factor 5( domain architecture ID 10652754)

eukaryotic translation initiation factor 5 catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
15-128 5.05e-51

domain present in translation initiation factor eIF2B and eIF5;


:

Pssm-ID: 214764  Cd Length: 110  Bit Score: 167.81  E-value: 5.05e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135     15 FYRYKMPRMMTKIEGRGngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDEKnGTSLVNGAHDTSKLAGLLENF 94
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGK-GRLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 15221135     95 IKKYVQCYGCGNPETEILITkTQMLQLKCAACGF 128
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE-NRLFFLKCEACGA 109
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 286-437 9.53e-39

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


:

Pssm-ID: 211399  Cd Length: 157  Bit Score: 137.36  E-value: 9.53e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135 286 ENAHEKLVNEIKELLSSGSSPTQLKTA--LASNSANPQEKMDALFSALFGGTGK-GFAKEVIKKKKYLLALMmmQEEAga 362
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESGLSELkeILKEAERLDVVKDKAVLVLAEVLFDeNIVKEIKKRKALLLKLV--TDEK-- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135 363 pAQMGLLNGIESFCMKASAEAAKEVALVIKGLYDEDILDEDVIVEWYNKGVK-------SSPVLKNVTPFIEWLQNAESE 435
Cdd:cd11561  77 -AQKALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKkyvskekSKKVRKAAEPFVEWLEEAEEE 155


                ..
gi 15221135 436 SE 437
Cdd:cd11561 156 EE 157
 
Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
15-128 5.05e-51

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 167.81  E-value: 5.05e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135     15 FYRYKMPRMMTKIEGRGngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDEKnGTSLVNGAHDTSKLAGLLENF 94
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGK-GRLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 15221135     95 IKKYVQCYGCGNPETEILITkTQMLQLKCAACGF 128
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE-NRLFFLKCEACGA 109
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 13-127 4.27e-47

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 157.67  E-value: 4.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135    13 DAFYRYKMPRMMTKIEGRGngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDEkNGTSLVNGAHDTSKLAGLLE 92
Cdd:pfam01873   4 DSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSIDE-NGRLIINGKFSAKQIEDLLD 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15221135    93 NFIKKYVQCYGCGNPETEiLITKTQMLQLKCAACG 127
Cdd:pfam01873  80 KYIEEYVLCPECGSPDTE-LIKENRLLFLKCEACG 113
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 286-437 9.53e-39

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 137.36  E-value: 9.53e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135 286 ENAHEKLVNEIKELLSSGSSPTQLKTA--LASNSANPQEKMDALFSALFGGTGK-GFAKEVIKKKKYLLALMmmQEEAga 362
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESGLSELkeILKEAERLDVVKDKAVLVLAEVLFDeNIVKEIKKRKALLLKLV--TDEK-- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135 363 pAQMGLLNGIESFCMKASAEAAKEVALVIKGLYDEDILDEDVIVEWYNKGVK-------SSPVLKNVTPFIEWLQNAESE 435
Cdd:cd11561  77 -AQKALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKkyvskekSKKVRKAAEPFVEWLEEAEEE 155


                ..
gi 15221135 436 SE 437
Cdd:cd11561 156 EE 157
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 365-437 4.03e-22

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 89.51  E-value: 4.03e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15221135   365 QMGLLNGIESFCMKaSAEAAKEVALVIKGLYDEDILDEDVIVEWYNKGVKSSP----VLKNVTPFIEWLQNAESESE 437
Cdd:pfam02020   1 QVDLLLALQEFCAK-LEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEKgmkkVRKQAKPFVEWLEEAEEESD 76
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
364-432 3.63e-20

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 84.26  E-value: 3.63e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15221135    364 AQMGLLNGIESFCMKaSAEAAKEVALVIKGLYDEDILDEDVIVEWYNKGV---KSSPVLKNVTPFIEWLQNA 432
Cdd:smart00515  13 EQLELLYAIEEFCVE-LEKLGKLLPKILKSLYDADILEEEAILKWYEKAVsaeGKKKVRKNAKPFVTWLQEA 83
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
 17-127 2.19e-15

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 72.54  E-value: 2.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135  17 RYKMPRMMTKIEGRgngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDekNGTSLVNGAHDTSKLAGLLENFIK 96
Cdd:COG1601  24 RFEVPEPEVRIEGN----RTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIE--GGRAILQGKFSPEDINALIDRYVK 97

                        90       100       110
                ....*....|....*....|....*....|.
gi 15221135  97 KYVQCYGCGNPETEiLITKTQMLQLKCAACG 127
Cdd:COG1601  98 EYVICPECGSPDTR-LVKEGRVLMLKCEACG 127
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
 17-127 2.53e-13

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 66.86  E-value: 2.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135   17 RYKMPRMMTKIEGRgngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDekNGTSLVNGAHDTSKLAGLLENFIK 96
Cdd:PRK03988  27 RFEVPKPDVRIEGN----RTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIE--GGRLILQGKFSPRVINEKIDRYVK 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15221135   97 KYVQCYGCGNPETEiLITKTQMLQLKCAACG 127
Cdd:PRK03988 101 EYVICPECGSPDTK-LIKEGRIWVLKCEACG 130
aIF-2beta TIGR00311
translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high ...
 17-127 6.67e-13

translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high enough to select only archaeal members. The suggested cutoff is set to include most eukaryotic members but largely exclude the related eIF-5. [Protein synthesis, Translation factors]


Pssm-ID: 129411  Cd Length: 133  Bit Score: 65.64  E-value: 6.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135    17 RYKMPRMMTKIEGRgngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDekNGTSLVNGAHDTSKLAGLLENFIK 96
Cdd:TIGR00311  22 RFEIPRVSIQIEGN----RTIIKNFREIAKALNRDEDHLYKYLLKELGTAGNLE--GGRLILQGKFTESLLQKRIDDYVR 95

                          90       100       110
                  ....*....|....*....|....*....|.
gi 15221135    97 KYVQCYGCGNPETEIlITKTQMLQLKCAACG 127
Cdd:TIGR00311  96 LYVICRECNSPDTEI-IKEGRVLLLKCLACG 125
 
Name Accession Description Interval E-value
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
15-128 5.05e-51

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 167.81  E-value: 5.05e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135     15 FYRYKMPRMMTKIEGRGngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDEKnGTSLVNGAHDTSKLAGLLENF 94
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGK-GRLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 15221135     95 IKKYVQCYGCGNPETEILITkTQMLQLKCAACGF 128
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE-NRLFFLKCEACGA 109
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 13-127 4.27e-47

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 157.67  E-value: 4.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135    13 DAFYRYKMPRMMTKIEGRGngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDEkNGTSLVNGAHDTSKLAGLLE 92
Cdd:pfam01873   4 DSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSIDE-NGRLIINGKFSAKQIEDLLD 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15221135    93 NFIKKYVQCYGCGNPETEiLITKTQMLQLKCAACG 127
Cdd:pfam01873  80 KYIEEYVLCPECGSPDTE-LIKENRLLFLKCEACG 113
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 286-437 9.53e-39

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 137.36  E-value: 9.53e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135 286 ENAHEKLVNEIKELLSSGSSPTQLKTA--LASNSANPQEKMDALFSALFGGTGK-GFAKEVIKKKKYLLALMmmQEEAga 362
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESGLSELkeILKEAERLDVVKDKAVLVLAEVLFDeNIVKEIKKRKALLLKLV--TDEK-- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135 363 pAQMGLLNGIESFCMKASAEAAKEVALVIKGLYDEDILDEDVIVEWYNKGVK-------SSPVLKNVTPFIEWLQNAESE 435
Cdd:cd11561  77 -AQKALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKkyvskekSKKVRKAAEPFVEWLEEAEEE 155


                ..
gi 15221135 436 SE 437
Cdd:cd11561 156 EE 157
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 365-437 4.03e-22

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 89.51  E-value: 4.03e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15221135   365 QMGLLNGIESFCMKaSAEAAKEVALVIKGLYDEDILDEDVIVEWYNKGVKSSP----VLKNVTPFIEWLQNAESESE 437
Cdd:pfam02020   1 QVDLLLALQEFCAK-LEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEKgmkkVRKQAKPFVEWLEEAEEESD 76
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
364-432 3.63e-20

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 84.26  E-value: 3.63e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15221135    364 AQMGLLNGIESFCMKaSAEAAKEVALVIKGLYDEDILDEDVIVEWYNKGV---KSSPVLKNVTPFIEWLQNA 432
Cdd:smart00515  13 EQLELLYAIEEFCVE-LEKLGKLLPKILKSLYDADILEEEAILKWYEKAVsaeGKKKVRKNAKPFVTWLQEA 83
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
 17-127 2.19e-15

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 72.54  E-value: 2.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135  17 RYKMPRMMTKIEGRgngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDekNGTSLVNGAHDTSKLAGLLENFIK 96
Cdd:COG1601  24 RFEVPEPEVRIEGN----RTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIE--GGRAILQGKFSPEDINALIDRYVK 97

                        90       100       110
                ....*....|....*....|....*....|.
gi 15221135  97 KYVQCYGCGNPETEiLITKTQMLQLKCAACG 127
Cdd:COG1601  98 EYVICPECGSPDTR-LVKEGRVLMLKCEACG 127
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 340-437 5.69e-15

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 72.29  E-value: 5.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135 340 AKEVIKKKKYLLALMMMQEEAgapaQMGLLNGIESFCMKaSAEAAKEVALVIKGLYDEDILDEDVIVEWYNK-----GVK 414
Cdd:cd11558  72 LKKLLSKWGPLLENYVKSQDD----QVELLLALEEFCLE-SEEGGPLFAKLLHALYDLDILEEEAILEWWEEpdagaDEE 146

                        90       100
                ....*....|....*....|...
gi 15221135 415 SSPVLKNVTPFIEWLQNAESESE 437
Cdd:cd11558 147 MKKVRELVKKFIEWLEEAEEESD 169
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
 17-127 2.53e-13

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 66.86  E-value: 2.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135   17 RYKMPRMMTKIEGRgngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDekNGTSLVNGAHDTSKLAGLLENFIK 96
Cdd:PRK03988  27 RFEVPKPDVRIEGN----RTIIRNFKEIADRLNRDPKHVAKFLLKELGTAGNIE--GGRLILQGKFSPRVINEKIDRYVK 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15221135   97 KYVQCYGCGNPETEiLITKTQMLQLKCAACG 127
Cdd:PRK03988 101 EYVICPECGSPDTK-LIKEGRIWVLKCEACG 130
aIF-2beta TIGR00311
translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high ...
 17-127 6.67e-13

translation initiation factor aIF-2, beta subunit, putative; The trusted cutoff is set high enough to select only archaeal members. The suggested cutoff is set to include most eukaryotic members but largely exclude the related eIF-5. [Protein synthesis, Translation factors]


Pssm-ID: 129411  Cd Length: 133  Bit Score: 65.64  E-value: 6.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135    17 RYKMPRMMTKIEGRgngiKTNVVNMVEIAKALGRPAAYTTKYFGCELGAQSKFDekNGTSLVNGAHDTSKLAGLLENFIK 96
Cdd:TIGR00311  22 RFEIPRVSIQIEGN----RTIIKNFREIAKALNRDEDHLYKYLLKELGTAGNLE--GGRLILQGKFTESLLQKRIDDYVR 95

                          90       100       110
                  ....*....|....*....|....*....|.
gi 15221135    97 KYVQCYGCGNPETEIlITKTQMLQLKCAACG 127
Cdd:TIGR00311  96 LYVICRECNSPDTEI-IKEGRVLLLKCLACG 125
PRK12336 PRK12336
translation initiation factor IF-2 subunit beta; Provisional
 17-127 6.96e-12

translation initiation factor IF-2 subunit beta; Provisional


Pssm-ID: 183451 [Multi-domain]  Cd Length: 201  Bit Score: 64.20  E-value: 6.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135   17 RYKMPRMMTKIEGrgngiKTNVV-NMVEIAKALGRPAAYTTKYFGCELGAQSKFDeknGTSLV-NGAHDTSKLAGLLENF 94
Cdd:PRK12336  23 RFSIPEPKIFIEG-----KTTILtNFGEIADALNRDPDHLMKFLQRELGTAGKIE---GGRAVfNGKFTEEDIQAAIDAY 94

                         90       100       110
                 ....*....|....*....|....*....|...
gi 15221135   95 IKKYVQCYGCGNPETEiLITKTQMLQLKCAACG 127
Cdd:PRK12336  95 VDEYVICSECGLPDTR-LVKEDRVLMLRCDACG 126
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 364-435 2.38e-11

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 62.62  E-value: 2.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15221135 364 AQMGLLNGIESFC------MKASAEaakevalVIKGLYDEDILDEDVIVEWYNKGVKS---SPVLKNVTPFIEWLQNAES 434
Cdd:cd11560 121 AELALLNKIQEYCyenmkfMKVFQK-------IVKLLYKADVLSEDAILKWYKKGHSPkgkQVFLKQMEPFVEWLQEAEE 193


                .
gi 15221135 435 E 435
Cdd:cd11560 194 E 194
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 342-409 9.10e-05

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 42.08  E-value: 9.10e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15221135 342 EVIKKKKYLLALMMMQEEAgapAQMGLLNGIESFC-MKASAEAAKEVALVIKGLYDEDILDEDVIVEWY 409
Cdd:cd11473  70 LVLKKYGPVLRELLKLIKK---DQLYLLLKIEKLClQLKLSELISLLEKILDLLYDADVLSEEAILSWF 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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