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Conserved domains on  [gi|15220145|ref|NP_175155|]
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Cyclin A3;3 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 49-186 1.53e-85

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410265  Cd Length: 136  Bit Score: 253.49  E-value: 1.53e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  49 DPQMCGLYVSDIYEYLRELEvkPKLRPLHDYIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKM 128
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAE--LKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNY 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15220145 129 VNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFE 186
Cdd:cd20562  79 VNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 190-304 2.63e-62

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410210  Cd Length: 111  Bit Score: 193.62  E-value: 2.63e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDfkVPNLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYK 269
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTL--NPHPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220145 270 AADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKF 304
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
 
Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 49-186 1.53e-85

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 253.49  E-value: 1.53e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  49 DPQMCGLYVSDIYEYLRELEvkPKLRPLHDYIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKM 128
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAE--LKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNY 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15220145 129 VNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFE 186
Cdd:cd20562  79 VNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 190-304 2.63e-62

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 193.62  E-value: 2.63e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDfkVPNLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYK 269
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTL--NPHPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220145 270 AADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKF 304
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
35-314 9.25e-52

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 176.89  E-value: 9.25e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  35 ENIQSGSDIDARS-DDPQMCGLYVSDIYEYLRELEVKpkLRPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETL 113
Cdd:COG5024 158 RESQSWQDLDATDqEDPLMVPEYASDIFEYLLKLELI--DLPNPNYLIK-QSLYEWSMRSILVDWLVEVHGKFGLLPETL 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 114 YLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFELGRPTTN 193
Cdd:COG5024 235 FLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPM 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 194 TFLRRFIRVAQEDFkvpnlQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECT-KYKAAD 272
Cdd:COG5024 315 SFLRRISKASDYDI-----FSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKIL--SQNQWDRTLIHYSgNYTNPD 387

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 15220145 273 LQVCVEIMLDlYLSRSEGASKAVREKYKQHKFqYVAAIPVYQ 314
Cdd:COG5024 388 LKPLNESNKE-NLQNPSVHHDAIFPKYPSPTF-GKASSPTGE 427
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 59-188 1.23e-50

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 164.23  E-value: 1.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145    59 DIYEYLRELEVKpkLRPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVG 138
Cdd:pfam00134   1 DIFQYLRELELK--YLPKPDYMDQ-QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15220145   139 VSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFELG 188
Cdd:pfam00134  78 VTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 190-313 2.24e-41

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 140.07  E-value: 2.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145   190 PTTNTFLRRFIRVAQEDfkvPNLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYK 269
Cdd:pfam02984   1 PTPLSFLRRFSKAADYL---HDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL--NSPEWTETLEHYTGYS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15220145   270 AADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKFQYVAAIPVY 313
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 97-180 2.15e-18

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 78.40  E-value: 2.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145     97 DWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITanTYTKQDVLKME 176
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTG--YFTEEEILRME 78


                   ....
gi 15220145    177 EDIL 180
Cdd:smart00385  79 RLLL 82
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 194-282 3.00e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.45  E-value: 3.00e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145    194 TFLRRFIRVAQedfkvPNLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKY-KAAD 272
Cdd:smart00385   1 DFLRRVCKALN-----LDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE--ETPPWTKELVHYTGYfTEEE 73

                           90
                   ....*....|
gi 15220145    273 LQVCVEIMLD 282
Cdd:smart00385  74 ILRMERLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 49-186 1.53e-85

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 253.49  E-value: 1.53e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  49 DPQMCGLYVSDIYEYLRELEvkPKLRPLHDYIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKM 128
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAE--LKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNY 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15220145 129 VNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFE 186
Cdd:cd20562  79 VNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 190-304 2.63e-62

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 193.62  E-value: 2.63e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDfkVPNLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYK 269
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTL--NPHPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220145 270 AADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKF 304
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 56-185 4.76e-58

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 183.22  E-value: 4.76e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  56 YVSDIYEYLRELEVKpkLRPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQ 135
Cdd:cd20504   2 YADDIYEYLRESELK--HRPKPDYMRK-QPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQ 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15220145 136 LVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20504  79 LVGTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 53-185 4.51e-57

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 180.80  E-value: 4.51e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  53 CGLYVSDIYEYLRELEVKPKLRPlhDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEH 132
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYAIDP--DYLSG-QPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRK 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15220145 133 WLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20507  78 KLQLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
35-314 9.25e-52

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 176.89  E-value: 9.25e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  35 ENIQSGSDIDARS-DDPQMCGLYVSDIYEYLRELEVKpkLRPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETL 113
Cdd:COG5024 158 RESQSWQDLDATDqEDPLMVPEYASDIFEYLLKLELI--DLPNPNYLIK-QSLYEWSMRSILVDWLVEVHGKFGLLPETL 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 114 YLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFELGRPTTN 193
Cdd:COG5024 235 FLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPM 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 194 TFLRRFIRVAQEDFkvpnlQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECT-KYKAAD 272
Cdd:COG5024 315 SFLRRISKASDYDI-----FSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKIL--SQNQWDRTLIHYSgNYTNPD 387

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 15220145 273 LQVCVEIMLDlYLSRSEGASKAVREKYKQHKFqYVAAIPVYQ 314
Cdd:COG5024 388 LKPLNESNKE-NLQNPSVHHDAIFPKYPSPTF-GKASSPTGE 427
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 59-188 1.23e-50

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 164.23  E-value: 1.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145    59 DIYEYLRELEVKpkLRPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVG 138
Cdd:pfam00134   1 DIFQYLRELELK--YLPKPDYMDQ-QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15220145   139 VSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFELG 188
Cdd:pfam00134  78 VTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 42-185 1.01e-47

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 157.42  E-value: 1.01e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  42 DIDA-RSDDPQMCGLYVSDIYEYLRELEVKPKLRplhDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYI 120
Cdd:cd20508   1 DIDEeNSDDPFQVSEYAKDIFDYMKEREEKFVVP---DYLEK-QTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLV 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15220145 121 DRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20508  77 DLYLSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 49-185 2.62e-47

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 155.92  E-value: 2.62e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  49 DPQMCGLYVSDIYEYLRELEVKpkLRPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKM 128
Cdd:cd20568   1 DPLMVAEYVPEIFEYLRELELK--TLPNPNYMDD-QKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRV 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15220145 129 VNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20568  78 VSLNKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 42-185 7.60e-45

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 150.19  E-value: 7.60e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  42 DIDARSDDPQMCGL-YVSDIYEYLRELEVKPKLRPlhdYIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYI 120
Cdd:cd20567   6 DIDEVDKNNPLAAVeYVEDIYSFYRKVEPESCVPP---YYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLI 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15220145 121 DRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20567  83 DRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 56-186 1.75e-43

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 145.97  E-value: 1.75e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  56 YVSDIYEYLRELEVKPKlrPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQ 135
Cdd:cd20561   4 YHEDIHTYLREMEVKCK--PKVGYMKK-QPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15220145 136 LVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFE 186
Cdd:cd20561  81 LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 56-186 1.13e-41

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 142.29  E-value: 1.13e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  56 YVSDIYEYLRELEVKpkLRPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQ 135
Cdd:cd20560  36 YAEDIHQYLREAELK--HRPKPGYMRK-QPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQ 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15220145 136 LVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFE 186
Cdd:cd20560 113 LVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 190-313 2.24e-41

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 140.07  E-value: 2.24e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145   190 PTTNTFLRRFIRVAQEDfkvPNLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYK 269
Cdd:pfam02984   1 PTPLSFLRRFSKAADYL---HDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL--NSPEWTETLEHYTGYS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15220145   270 AADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKFQYVAAIPVY 313
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 49-185 3.07e-40

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 137.69  E-value: 3.07e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  49 DPQMCGLYVSDIYEYLRELEVKPKLRPlhDYIEKiqEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKM 128
Cdd:cd20566   1 NPQLCSDYVKDIYQYLRQLEVQQSIRP--HYLDG--KEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQP 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15220145 129 VNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20566  77 VSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 53-185 4.91e-40

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 136.93  E-value: 4.91e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  53 CGLYVSDIYEYLRELEVKPKLRPlhDYIEKiqEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEH 132
Cdd:cd20565   1 CSEYVKDIYAYLRQLEEEQAVRP--KYLEG--QEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKK 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15220145 133 WLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20565  77 MLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 92-187 1.71e-30

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 110.87  E-value: 1.71e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  92 RGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQD 171
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                        90
                ....*....|....*.
gi 15220145 172 VLKMEEDILLALEFEL 187
Cdd:cd20542  81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 59-185 3.68e-30

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 111.25  E-value: 3.68e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  59 DIYEYLRELEVKPKlrPLHDYIEKiQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSL-KMVNEHWLQLV 137
Cdd:cd20519   7 EVWDLMLKKEELYK--RDRDFLNR-HPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTqTNVPKTQLQLI 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15220145 138 GVSAMFIASKYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20519  84 GITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 190-311 4.46e-24

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 94.68  E-value: 4.46e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDfkvpnLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARfIILPNQHPWSQMLEECTKYK 269
Cdd:cd20511   1 PTPYVFLVRFLKAAQSD-----KKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTAR-CTLNKTPEWTSTLEFHTGYS 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15220145 270 AADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKFQYVAAIP 311
Cdd:cd20511  75 ESQLMECARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLP 116
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 92-183 6.63e-24

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 93.55  E-value: 6.63e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  92 RGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYTKQD 171
Cdd:cd20536   2 RAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTREQ 81

                        90
                ....*....|..
gi 15220145 172 VLKMEEDILLAL 183
Cdd:cd20536  82 ICNLECIILTKL 93
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 190-305 2.73e-23

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 92.36  E-value: 2.73e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDFKVPNLQLeplccYLSELSMLDYS-CVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKY 268
Cdd:cd20505   1 PTSNWFLERFLKHSNADEKTKSLAM-----YLCELSLIDADpYLKYLPSVIAAAAVCLANHTL--GNEVWPQKLARSTGY 73

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15220145 269 KAADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKFQ 305
Cdd:cd20505  74 SLEDLLPCLRDLHRTFLNAPSSPQQAIREKYKSSKYH 110
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 69-183 1.93e-22

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 91.06  E-value: 1.93e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  69 VKPKLRPLHD-YIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRF-LSLKMVNEHWLQLVGVSAMFIAS 146
Cdd:cd20580  19 LKKESKYVHDkHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIAS 98

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15220145 147 KYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLAL 183
Cdd:cd20580  99 KLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKAL 135
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 89-183 2.52e-22

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 89.30  E-value: 2.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  89 PSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANTYT 168
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                        90
                ....*....|....*
gi 15220145 169 KQDVLKMEEDILLAL 183
Cdd:cd20521  81 YEDVVRMMGEIVAAL 95
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 67-176 6.90e-22

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 90.05  E-value: 6.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  67 LEVKPKLRPLHDYIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIAS 146
Cdd:cd20515  31 LSLEERYLPSASYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLAS 110

                        90       100       110
                ....*....|....*....|....*....|
gi 15220145 147 KYEEKRRPKVEDFCYITANTYTKQDVLKME 176
Cdd:cd20515 111 KLKETIPLTAEKLCIYTDNSITLQELLDWE 140
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 190-284 1.92e-20

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 84.28  E-value: 1.92e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDfkvpnLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFiILPNQHPWSQMLEECTKYK 269
Cdd:cd20537   1 PTPLSFLRRYLSLLGLD-----EKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARK-ILGEPPPSPQLLQLVTGYS 74

                        90
                ....*....|....*
gi 15220145 270 AADLQVCVEIMLDLY 284
Cdd:cd20537  75 ENDLQECAKELLELL 89
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 87-185 5.28e-20

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 84.55  E-value: 5.28e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  87 ITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSL-KMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITAN 165
Cdd:cd20579  38 LQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATqENVVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDG 117

                        90       100
                ....*....|....*....|
gi 15220145 166 TYTKQDVLKMEEDILLALEF 185
Cdd:cd20579 118 ACTEDEILSMELIIMKALKW 137
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 190-307 1.28e-19

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 82.66  E-value: 1.28e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDfkvpnLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYK 269
Cdd:cd20509   1 PLPLHFLRRFSKAGGAD-----AQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKIL--DEPEWTPTLEHYSTYS 73

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15220145 270 AADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKFQYV 307
Cdd:cd20509  74 EEDLLPIVQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 97-180 2.15e-18

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 78.40  E-value: 2.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145     97 DWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITanTYTKQDVLKME 176
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTG--YFTEEEILRME 78


                   ....
gi 15220145    177 EDIL 180
Cdd:smart00385  79 RLLL 82
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 75-186 6.10e-18

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 79.25  E-value: 6.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  75 PLHDYIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRP 154
Cdd:cd20573  38 PSVSYFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPL 117

                        90       100       110
                ....*....|....*....|....*....|..
gi 15220145 155 KVEDFCYITANTYTKQDVLKMEEDILLALEFE 186
Cdd:cd20573 118 TAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 67-185 3.70e-16

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 74.26  E-value: 3.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  67 LEVKPKLRPLHDYIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIAS 146
Cdd:cd20574  31 LTIEERYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLAS 110

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15220145 147 KYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEF 185
Cdd:cd20574 111 KLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 95-184 9.07e-16

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 71.65  E-value: 9.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  95 LVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEK--RRPKVEDFCYITANTYTKQDV 172
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESkaRVPLLSELSKMCCNSYGEELF 81

                        90
                ....*....|..
gi 15220145 173 LKMEEDILLALE 184
Cdd:cd20559  82 IQMEMHILNTLN 93
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 67-186 2.04e-15

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 72.33  E-value: 2.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  67 LEVKPKLRPLHDYIEKIQEDITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIAS 146
Cdd:cd20575  31 LRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLAS 110

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15220145 147 KYEEKRRPKVEDFCYITANTYTKQDVLKMEEDILLALEFE 186
Cdd:cd20575 111 KLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 190-311 4.52e-15

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 70.39  E-value: 4.52e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDFKvpNLQLEPlccYLSELSMLDYSCVKFVPSLLAASAVFLArfIILPNQHPWSQMLEECTKYK 269
Cdd:cd20510   1 PLSYRFLRRYAKCARASME--TLTLAR---YILELSLMEYQFVQERASKLAAAALLLA--LKMKNLGEWTPTLEYYSGYS 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15220145 270 AADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKFQYVAAIP 311
Cdd:cd20510  74 AEDLLPLVRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 195-304 8.89e-15

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 69.56  E-value: 8.89e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 195 FLRRFIRVAQEDFkvpnlQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYKAADLQ 274
Cdd:cd20512   5 FLRRISKADDYDI-----QTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKML--GRGDWNDNLVHYSGYTESQLI 77

                        90       100       110
                ....*....|....*....|....*....|
gi 15220145 275 VCVEIMLDlYLSRSEGASKAVREKYKQHKF 304
Cdd:cd20512  78 PCADIMLE-YLVKPIKHHDAFFKKYSSKKF 106
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 190-304 1.20e-14

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 69.08  E-value: 1.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDFKVpnlqlEPLCCYLSELSMLDYS-CVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKY 268
Cdd:cd20564   1 PTINQFLTQYFLHQQANCKV-----ESLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTV--TGQSWPESLVQKTGY 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15220145 269 KAADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKF 304
Cdd:cd20564  74 TLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKY 109
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 92-185 9.09e-14

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 66.47  E-value: 9.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  92 RGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEK--RRPKVEDF-CYITANTYT 168
Cdd:cd20528   7 RRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELddNIPKISDLnRYLCNSVYS 86

                        90
                ....*....|....*..
gi 15220145 169 KQDVLKMEEDILLALEF 185
Cdd:cd20528  87 KQEYLQMELLILEFFQW 103
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 190-318 2.77e-13

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 65.60  E-value: 2.77e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVAQEDFKVPNLQLeplccYLSELSMLDYS-CVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKY 268
Cdd:cd20563   1 PTINQFLLQYLKRHEVCEKTENLAM-----YVAELSLLEVDpFLKYLPSLTAAAAYCLANYTV--NKVFWPETLAAFTGY 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15220145 269 KAADLQVCVEIMLDLYLSRSEGASKAVREKYKQHKFQYVAAIPVYQELPV 318
Cdd:cd20563  74 SLSEIVPCLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 194-282 3.00e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.45  E-value: 3.00e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145    194 TFLRRFIRVAQedfkvPNLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKY-KAAD 272
Cdd:smart00385   1 DFLRRVCKALN-----LDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE--ETPPWTKELVHYTGYfTEEE 73

                           90
                   ....*....|
gi 15220145    273 LQVCVEIMLD 282
Cdd:smart00385  74 ILRMERLLLE 83
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 95-178 1.20e-11

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 59.73  E-value: 1.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  95 LVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPkVEDFCYITAntYTKQDVLK 174
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRT-LKEIAKVSG--VSEKELRK 78


                ....
gi 15220145 175 MEED 178
Cdd:cd00043  79 AEKE 82
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 217-316 9.36e-11

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 58.02  E-value: 9.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 217 LCCYLSELSMLDYSCVKFVPSLLAASAVFLARfIILPNQHPWSQMLEECTKYKAADLQVCVeimldLYLSRS-------- 288
Cdd:cd20522   2 LASYICELSLLHTELGRYSPAVIAASCLLLAR-VLLNQALPWPSQLEEFTGFSLEDLLSCV-----LHLHKKcfhedspk 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 15220145 289 ---EGASKAVREKYKQHKFQYVAAIPV--YQEL 316
Cdd:cd20522  76 dyrNVSLTAVKQRYEDERFLSISKIKVmsYEEL 108
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 96-187 1.01e-10

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 57.71  E-value: 1.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  96 VDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKY--EEKRRPKVEDFCYITANTYTKQDVL 173
Cdd:cd20526   6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAEVL 85

                        90
                ....*....|....
gi 15220145 174 KMEEDILLALEFEL 187
Cdd:cd20526  86 RMERIILDKLHWDL 99
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 87-183 6.25e-10

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 55.65  E-value: 6.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  87 ITPSKRGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDFCYITANT 166
Cdd:cd20517   1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                        90
                ....*....|....*..
gi 15220145 167 YTKQDVLKMEEDILLAL 183
Cdd:cd20517  81 FTNLELINQEKDILEAL 97
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 190-280 8.21e-10

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 55.06  E-value: 8.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVA------------QEDFKVPNLQLEpLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFI--ILPnq 255
Cdd:cd20529   1 PTPAHFLEYYLSQGvlfvddhdglpsELLEKVKEYVRK-YADFFLDLSLQDYAFLNYKPSLLAAACIAAARKAlgLSP-- 77

                        90       100
                ....*....|....*....|....*
gi 15220145 256 hPWSQMLEECTKYKAADLQVCVEIM 280
Cdd:cd20529  78 -TWPEELEKLTGYSEDELEPCVELL 101
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 96-159 1.13e-08

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 51.93  E-value: 1.13e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15220145  96 VDWLVEVAEEFELVSETLYLTVSYIDRFLS---LKMVNEHWLQLVGVSAMFIASKYEEKRRPKVEDF 159
Cdd:cd20543   6 IDWILKVRSRYGFGPLTAYLAVNYLDRFLSsydLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDL 72
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 195-311 3.41e-08

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 51.04  E-value: 3.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 195 FLRRFIRVAQEDfkvpnLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYKAADLQ 274
Cdd:cd20570   6 FLRRASKAGSAD-----VEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVL--DGGKWSLTQQYYTGYTEDDLK 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15220145 275 VCVEIMLDLYLSRSEGASK--AVREKYKQHKFQYVAAIP 311
Cdd:cd20570  79 PIMQHMAKNVVKVNEGLTKhvAVKNKYASSKLMKISTIP 117
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 195-311 5.87e-08

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 50.66  E-value: 5.87e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 195 FLRRFIRVAQEDfkvpnLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARFIIlpNQHPWSQMLEECTKYKAADLQ 274
Cdd:cd20569   6 FLRRASKIGEVD-----VEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKIL--DNGEWTPTLQHYMSYTEESLL 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15220145 275 VCVEIMLDLYLSRSEGASK--AVREKYKQHKFQYVAAIP 311
Cdd:cd20569  79 PVMQHMAKNVVKVNQGLTKhmTVKNKYASSKQMKISTLP 117
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 106-180 5.77e-07

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 46.96  E-value: 5.77e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15220145 106 FELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRR--PKVEDFCYITANTYTKQDVLKMEEDIL 180
Cdd:cd20523  15 YGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDQniPSAEDLIRISQCGCTAADLMRMEGIIL 91
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 193-280 7.11e-07

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 46.89  E-value: 7.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 193 NTFLRRFIRVAQEDFKVPNLQLEPLC-------CYLSELSMLDYSCVKFVPSLLAASAVFLArfiilpnqHPWSQMLEEC 265
Cdd:cd20520   9 NLYLQLAQLNPPPKENDSAFLLPQYSldrfvraAQLLDLCILDIGSLQFSYSVLAASALYLV--------SPDDEAIEQV 80

                        90
                ....*....|....*
gi 15220145 266 TKYKAADLQVCVEIM 280
Cdd:cd20520  81 TGYSWEQLAPCVEWM 95
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 99-180 7.21e-07

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 46.74  E-value: 7.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  99 LVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKY--EEKRRPKVEDFCYITANTYTKQDVLKME 176
Cdd:cd20583   9 LLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRME 88


                ....
gi 15220145 177 EDIL 180
Cdd:cd20583  89 KIIL 92
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 190-266 2.32e-05

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 42.33  E-value: 2.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRF----IRVAQEDFKVPNLQLEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLA-------RFIILPNQHPW 258
Cdd:cd20722   1 PTLQFFLEHFsslrLENRELSCAEEARKARALARYLAELSLADYAFNQYPPSLLAICSLELAdrmlqhrSPITERLSGYP 80


                ....*...
gi 15220145 259 SQMLEECT 266
Cdd:cd20722  81 QSALEDCV 88
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 92-179 1.62e-04

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 40.22  E-value: 1.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145  92 RGVLVDWLVEVAEEFELVSETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKY--EEKRRPKVEDFCYITANTYTK 169
Cdd:cd20584   2 RDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTV 81

                        90
                ....*....|
gi 15220145 170 QDVLKMEEDI 179
Cdd:cd20584  82 SDLKRMEKII 91
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 190-285 2.53e-04

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 39.80  E-value: 2.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 190 PTTNTFLRRFIRVA-QEDFKVPNLQ-LEPLCCYLSELSMLDYSCVKFVPSLLAASAVFLARfiILPNQHPWSQMLEECTK 267
Cdd:cd20721   1 PTILTFLRMYIERLsLESGAAHASRpLERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAE--IMHNRPAAWAAEALSAE 78

                        90       100
                ....*....|....*....|....*
gi 15220145 268 YKAADLQV-------CVEIMLDLYL 285
Cdd:cd20721  79 LAAVLVHTrapevlrCVQALHQLVG 103
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 111-247 7.87e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 37.40  E-value: 7.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220145 111 ETLYLTVSYIDRFLSLKMVNEHWLQLVGVSAMFIASKYEEKRRpKVEDFCYITANTYTKQD------VLKMEEDILLALE 184
Cdd:COG5333  64 TVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPR-DISIESFEARDLWSEEPkssrerILEYEFELLEALD 142

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15220145 185 FELGRPTTNTFLRRFIRVAQEDFKVPNLQLEPLCCYLSELSmldYSCVKFVPSLLAASAVFLA 247
Cdd:COG5333 143 FDLHVHHPYKYLEGFLKDLQEKDKYKLLQIAWKIINDALRT---DLCLLYPPHIIALAALLIA 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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