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Conserved domains on  [gi|15220147|ref|NP_175156|]
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CYCLIN A3;4 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 88-225 5.53e-90

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410265  Cd Length: 136  Bit Score: 266.58  E-value: 5.53e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  88 DPQMCEPFASDIcaYLREMEGKPKHRPLPDYIEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKP 167
Cdd:cd20562   1 DPQMCSLYATDI--YLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNY 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15220147 168 INRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFE 225
Cdd:cd20562  79 VNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 229-343 9.49e-64

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410210  Cd Length: 111  Bit Score: 198.63  E-value: 9.49e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDfkDSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRPkqHPWNQMLEEYTKYK 308
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220147 309 AADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKY 343
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
 
Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 88-225 5.53e-90

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 266.58  E-value: 5.53e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  88 DPQMCEPFASDIcaYLREMEGKPKHRPLPDYIEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKP 167
Cdd:cd20562   1 DPQMCSLYATDI--YLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNY 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15220147 168 INRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFE 225
Cdd:cd20562  79 VNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 229-343 9.49e-64

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 198.63  E-value: 9.49e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDfkDSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRPkqHPWNQMLEEYTKYK 308
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220147 309 AADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKY 343
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 98-227 3.21e-56

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 179.63  E-value: 3.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147    98 DICAYLREMEgkPKHRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVG 177
Cdd:pfam00134   1 DIFQYLRELE--LKYLPKPDYMDQ-QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15220147   178 VSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFELG 227
Cdd:pfam00134  78 VTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
88-343 9.38e-45

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 159.56  E-value: 9.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  88 DPQMCEPFASDICAYLREMEgkPKHRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKP 167
Cdd:COG5024 173 DPLMVPEYASDIFEYLLKLE--LIDLPNPNYLIK-QSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRV 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 168 INRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFELGSPTIKTFLRRFTRVaqeDFK 247
Cdd:COG5024 250 VSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA---SDY 326

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 248 DSQLQIefLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRpkQHPWNQMLEEYT-KYKAADLQ-VCVGIIHDL-YL 324
Cdd:COG5024 327 DIFSRT--PAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILS--QNQWDRTLIHYSgNYTNPDLKpLNESNKENLqNP 402

                       250
                ....*....|....*....
gi 15220147 325 SRRgntLEAVRNKYKQHKY 343
Cdd:COG5024 403 SVH---HDAIFPKYPSPTF 418
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 229-352 7.33e-41

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 139.68  E-value: 7.33e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147   229 PTIKTFLRRFTRVAQEDfkdSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIrpKQHPWNQMLEEYTKYK 308
Cdd:pfam02984   1 PTPLSFLRRFSKAADYL---HDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL--NSPEWTETLEHYTGYS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15220147   309 AADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKYKCVATMPVS 352
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 136-219 2.74e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.48  E-value: 2.74e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147    136 DWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDntFTKQEVVSME 215
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....
gi 15220147    216 ADIL 219
Cdd:smart00385  79 RLLL 82
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 233-321 4.22e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.45  E-value: 4.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147    233 TFLRRFTRVAQedfkdSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIrpKQHPWNQMLEEYTKY-KAAD 311
Cdd:smart00385   1 DFLRRVCKALN-----LDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE--ETPPWTKELVHYTGYfTEEE 73

                           90
                   ....*....|
gi 15220147    312 LQVCVGIIHD 321
Cdd:smart00385  74 ILRMERLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 88-225 5.53e-90

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 266.58  E-value: 5.53e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  88 DPQMCEPFASDIcaYLREMEGKPKHRPLPDYIEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKP 167
Cdd:cd20562   1 DPQMCSLYATDI--YLNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNY 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15220147 168 INRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFE 225
Cdd:cd20562  79 VNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 95-224 3.90e-64

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 200.17  E-value: 3.90e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  95 FASDICAYLREMEgkPKHRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQ 174
Cdd:cd20504   2 YADDIYEYLRESE--LKHRPKPDYMRK-QPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQ 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15220147 175 LVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20504  79 LVGTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 229-343 9.49e-64

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 198.63  E-value: 9.49e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDfkDSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRPkqHPWNQMLEEYTKYK 308
Cdd:cd20506   1 PTIKTFLRRFLRAAQAS--VPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP--HPWNPTLEHYTGYK 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220147 309 AADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKY 343
Cdd:cd20506  77 AADLKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 92-224 2.03e-60

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 190.82  E-value: 2.03e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  92 CEPFASDICAYLREMEGKPKhrPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQ 171
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYA--IDPDYLSG-QPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRK 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15220147 172 KLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20507  78 KLQLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 98-227 3.21e-56

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 179.63  E-value: 3.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147    98 DICAYLREMEgkPKHRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVG 177
Cdd:pfam00134   1 DIFQYLRELE--LKYLPKPDYMDQ-QPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 15220147   178 VSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFELG 227
Cdd:pfam00134  78 VTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 95-225 2.44e-48

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 159.84  E-value: 2.44e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  95 FASDICAYLREMEGKPKhrPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQ 174
Cdd:cd20561   4 YHEDIHTYLREMEVKCK--PKVGYMKK-QPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15220147 175 LVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFE 225
Cdd:cd20561  81 LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 74-225 3.97e-48

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 160.39  E-value: 3.97e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  74 MIPEASVLIESR-----SVDPQMCEPFASDICAYLREMEgkPKHRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLV 148
Cdd:cd20560  10 MLVDTSLQSQSEddsaaDVDVLAVPEYAEDIHQYLREAE--LKHRPKPGYMRK-QPDITTGMRTILVDWLVEVGEEYKLQ 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15220147 149 SDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFE 225
Cdd:cd20560  87 TETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 95-224 2.55e-47

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 157.51  E-value: 2.55e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  95 FASDICAYLREMEgkPKHRPlPDYIEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQ 174
Cdd:cd20567  21 YVEDIYSFYRKVE--PESCV-PPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQ 97

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15220147 175 LVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20567  98 LVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 88-224 5.41e-47

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 156.65  E-value: 5.41e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  88 DPQMCEPFASDICAYLREMEGKpkhRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKP 167
Cdd:cd20508   9 DPFQVSEYAKDIFDYMKEREEK---FVVPDYLEK-QTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKV 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15220147 168 INRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20508  85 VKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 88-224 3.87e-45

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 151.68  E-value: 3.87e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  88 DPQMCEPFASDICAYLREMEgkPKHRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKP 167
Cdd:cd20568   1 DPLMVAEYVPEIFEYLRELE--LKTLPNPNYMDD-QKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRV 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15220147 168 INRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20568  78 VSLNKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
88-343 9.38e-45

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 159.56  E-value: 9.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  88 DPQMCEPFASDICAYLREMEgkPKHRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKP 167
Cdd:COG5024 173 DPLMVPEYASDIFEYLLKLE--LIDLPNPNYLIK-QSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRV 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 168 INRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQFELGSPTIKTFLRRFTRVaqeDFK 247
Cdd:COG5024 250 VSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA---SDY 326

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 248 DSQLQIefLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRpkQHPWNQMLEEYT-KYKAADLQ-VCVGIIHDL-YL 324
Cdd:COG5024 327 DIFSRT--PAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILS--QNQWDRTLIHYSgNYTNPDLKpLNESNKENLqNP 402

                       250
                ....*....|....*....
gi 15220147 325 SRRgntLEAVRNKYKQHKY 343
Cdd:COG5024 403 SVH---HDAIFPKYPSPTF 418
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 88-224 5.92e-42

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 143.08  E-value: 5.92e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  88 DPQMCEPFASDICAYLREMEGKPKHRPlpDYIEKvqSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKP 167
Cdd:cd20566   1 NPQLCSDYVKDIYQYLRQLEVQQSIRP--HYLDG--KEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQP 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15220147 168 INRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20566  77 VSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 229-352 7.33e-41

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 139.68  E-value: 7.33e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147   229 PTIKTFLRRFTRVAQEDfkdSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIrpKQHPWNQMLEEYTKYK 308
Cdd:pfam02984   1 PTPLSFLRRFSKAADYL---HDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL--NSPEWTETLEHYTGYS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 15220147   309 AADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKYKCVATMPVS 352
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 92-224 2.84e-39

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 136.16  E-value: 2.84e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147  92 CEPFASDICAYLREMEGKPKHRPlpDYIEKvqSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQ 171
Cdd:cd20565   1 CSEYVKDIYAYLRQLEEEQAVRP--KYLEG--QEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKK 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15220147 172 KLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20565  77 MLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 111-224 1.65e-38

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 133.98  E-value: 1.65e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 111 KHRPLPDYIEKvQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSV-KPINRQKLQLVGVSAMLIASKYEE 189
Cdd:cd20519  18 LYKRDRDFLNR-HPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTqTNVPKTQLQLIGITCLFIAAKLEE 96

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220147 190 IGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20519  97 IYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 131-226 2.48e-30

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 111.64  E-value: 2.48e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 131 RAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQE 210
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                        90
                ....*....|....*.
gi 15220147 211 VVSMEADILLALQFEL 226
Cdd:cd20542  81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 119-224 2.48e-29

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 110.32  E-value: 2.48e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 119 IEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRF-LSVKPINRQKLQLVGVSAMLIASKYEEIGPPKVED 197
Cdd:cd20580  31 FLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASKLEEIYPPKLHE 110

                        90       100
                ....*....|....*....|....*..
gi 15220147 198 FCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20580 111 FAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 130-222 1.69e-28

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 106.64  E-value: 1.69e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 130 MRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFTKQ 209
Cdd:cd20536   1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                        90
                ....*....|...
gi 15220147 210 EVVSMEADILLAL 222
Cdd:cd20536  81 QICNLECIILTKL 93
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 114-225 3.76e-28

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 107.38  E-value: 3.76e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 114 PLPDYIEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPP 193
Cdd:cd20515  39 PSASYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKETIPL 118

                        90       100       110
                ....*....|....*....|....*....|..
gi 15220147 194 KVEDFCYITDNTFTKQEVVSMEADILLALQFE 225
Cdd:cd20515 119 TAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 102-224 9.95e-28

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 106.12  E-value: 9.95e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 102 YLREMEGKPKHrPLpdyiekvqsdLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSV-KPINRQKLQLVGVSA 180
Cdd:cd20579  25 YLRDKNFLQKH-PL----------LQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATqENVVKTRLQLIGISS 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15220147 181 MLIASKYEEIGPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20579  94 LFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 128-222 2.03e-26

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 100.85  E-value: 2.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 128 PHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNTFT 207
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                        90
                ....*....|....*
gi 15220147 208 KQEVVSMEADILLAL 222
Cdd:cd20521  81 YEDVVRMMGEIVAAL 95
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 111-225 9.29e-24

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 95.83  E-value: 9.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 111 KHRPLPDYIEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEI 190
Cdd:cd20575  36 RYVPRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRET 115

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15220147 191 GPPKVEDFCYITDNTFTKQEVVSMEADILLALQFE 225
Cdd:cd20575 116 TPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 114-225 2.12e-22

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 91.96  E-value: 2.12e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 114 PLPDYIEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPP 193
Cdd:cd20573  38 PSVSYFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPL 117

                        90       100       110
                ....*....|....*....|....*....|..
gi 15220147 194 KVEDFCYITDNTFTKQEVVSMEADILLALQFE 225
Cdd:cd20573 118 TAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 229-323 1.02e-21

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 88.13  E-value: 1.02e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDfkdsqLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRPkQHPWNQMLEEYTKYK 308
Cdd:cd20537   1 PTPLSFLRRYLSLLGLD-----EKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGE-PPPSPQLLQLVTGYS 74

                        90
                ....*....|....*
gi 15220147 309 AADLQVCVGIIHDLY 323
Cdd:cd20537  75 ENDLQECAKELLELL 89
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 229-343 3.52e-21

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 87.35  E-value: 3.52e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDFKdsqlqIEFLCCYLSELSMLDYT-CVKYLPSLLSASAVFLARFIIRpkQHPWNQMLEEYTKY 307
Cdd:cd20505   1 PTSNWFLERFLKHSNADEK-----TKSLAMYLCELSLIDADpYLKYLPSVIAAAAVCLANHTLG--NEVWPQKLARSTGY 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15220147 308 KAADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKY 343
Cdd:cd20505  74 SLEDLLPCLRDLHRTFLNAPSSPQQAIREKYKSSKY 109
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 111-224 1.24e-20

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 87.35  E-value: 1.24e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 111 KHRPLPDYIEKVQSDLTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEI 190
Cdd:cd20574  36 RYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKET 115

                        90       100       110
                ....*....|....*....|....*....|....
gi 15220147 191 GPPKVEDFCYITDNTFTKQEVVSMEADILLALQF 224
Cdd:cd20574 116 IPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 136-219 2.74e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.48  E-value: 2.74e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147    136 DWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDntFTKQEVVSME 215
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....
gi 15220147    216 ADIL 219
Cdd:smart00385  79 RLLL 82
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 229-350 3.47e-19

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 82.35  E-value: 3.47e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDfkdsqLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRpKQHPWNQMLEEYTKYK 308
Cdd:cd20511   1 PTPYVFLVRFLKAAQSD-----KKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLN-KTPEWTSTLEFHTGYS 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15220147 309 AADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKYKCVATMP 350
Cdd:cd20511  75 ESQLMECARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLP 116
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 234-346 3.82e-19

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 81.89  E-value: 3.82e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 234 FLRRFTRVAQEDfkdsqLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRPKQhpWNQMLEEYTKYKAADLQ 313
Cdd:cd20509   6 FLRRFSKAGGAD-----AQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPE--WTPTLEHYSTYSEEDLL 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 15220147 314 VCVGIIHDLYLSRRGNTLEAVRNKYKQHKYKCV 346
Cdd:cd20509  79 PIVQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 129-224 8.44e-18

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 78.03  E-value: 8.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 129 HMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGP--PKVEDFCYITDN-T 205
Cdd:cd20528   5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLNRYLCNsV 84

                        90
                ....*....|....*....
gi 15220147 206 FTKQEVVSMEADILLALQF 224
Cdd:cd20528  85 YSKQEYLQMELLILEFFQW 103
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 126-224 3.40e-15

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 70.67  E-value: 3.40e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 126 LTPHMRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGPPKVEDFCYITDNT 205
Cdd:cd20517   1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                        90
                ....*....|....*....
gi 15220147 206 FTKQEVVSMEADILLALQF 224
Cdd:cd20517  81 FTNLELINQEKDILEALKW 99
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 229-357 1.34e-14

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 69.84  E-value: 1.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVaqedfKDSQLQIEFLCCYLSELSMLDYT-CVKYLPSLLSASAVFLARFIIrpKQHPWNQMLEEYTKY 307
Cdd:cd20563   1 PTINQFLLQYLKR-----HEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTV--NKVFWPETLAAFTGY 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15220147 308 KAADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKYKCVATMPVSPELPL 357
Cdd:cd20563  74 SLSEIVPCLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 229-350 4.34e-14

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 68.08  E-value: 4.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDFKdsQLQiefLCCYLSELSMLDYTCVKYLPSLLSASAVFLArfiIRPKQ-HPWNQMLEEYTKY 307
Cdd:cd20510   1 PLSYRFLRRYAKCARASME--TLT---LARYILELSLMEYQFVQERASKLAAAALLLA---LKMKNlGEWTPTLEYYSGY 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15220147 308 KAADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKYKCVATMP 350
Cdd:cd20510  73 SAEDLLPLVRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 234-344 2.13e-13

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 66.10  E-value: 2.13e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 234 FLRRFTRVAQEDFkdsqlQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIrpKQHPWNQMLEEYTKYKAADLQ 313
Cdd:cd20512   5 FLRRISKADDYDI-----QTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKML--GRGDWNDNLVHYSGYTESQLI 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 15220147 314 VCVGIIHDlYLSRRGNTLEAVRNKYKQHKYK 344
Cdd:cd20512  78 PCADIMLE-YLVKPIKHHDAFFKKYSSKKFL 107
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 229-343 2.36e-13

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 65.62  E-value: 2.36e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDFKdsqlqIEFLCCYLSELSMLDYT-CVKYLPSLLSASAVFLARFIIrpKQHPWNQMLEEYTKY 307
Cdd:cd20564   1 PTINQFLTQYFLHQQANCK-----VESLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTV--TGQSWPESLVQKTGY 73

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15220147 308 KAADLQVCVGIIHDLYLSRRGNTLEAVRNKYKQHKY 343
Cdd:cd20564  74 TLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKY 109
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 134-222 1.86e-12

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 62.79  E-value: 1.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 134 LVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIGP--PKVEDFCYITDNTFTKQEV 211
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                        90
                ....*....|.
gi 15220147 212 VSMEADILLAL 222
Cdd:cd20559  82 IQMEMHILNTL 92
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 233-321 4.22e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 61.45  E-value: 4.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147    233 TFLRRFTRVAQedfkdSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIrpKQHPWNQMLEEYTKY-KAAD 311
Cdd:smart00385   1 DFLRRVCKALN-----LDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE--ETPPWTKELVHYTGYfTEEE 73

                           90
                   ....*....|
gi 15220147    312 LQVCVGIIHD 321
Cdd:smart00385  74 ILRMERLLLE 83
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 255-351 4.36e-12

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 62.26  E-value: 4.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 255 FLCCYLSELSMLDYTCVKYLPSLLSASAVFLARfIIRPKQHPWNQMLEEYTKYKAADLQVCVGIIH------DLYLSRRG 328
Cdd:cd20522   1 CLASYICELSLLHTELGRYSPAVIAASCLLLAR-VLLNQALPWPSQLEEFTGFSLEDLLSCVLHLHkkcfheDSPKDYRN 79

                        90       100
                ....*....|....*....|...
gi 15220147 329 NTLEAVRNKYKQHKYKCVATMPV 351
Cdd:cd20522  80 VSLTAVKQRYEDERFLSISKIKV 102
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 134-215 9.65e-12

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 60.50  E-value: 9.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 134 LVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEEIgPPKVEDFCYITDNtfTKQEVVS 213
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVSGV--SEKELRK 78


                ..
gi 15220147 214 ME 215
Cdd:cd00043  79 AE 80
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 229-319 9.32e-11

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 58.14  E-value: 9.32e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVA-----------QEDFKDSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRPKQhPW 297
Cdd:cd20529   1 PTPAHFLEYYLSQGvlfvddhdglpSELLEKVKEYVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSP-TW 79

                        90       100
                ....*....|....*....|..
gi 15220147 298 NQMLEEYTKYKAADLQVCVGII 319
Cdd:cd20529  80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 135-198 2.04e-10

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 56.94  E-value: 2.04e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15220147 135 VDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQK---LQLVGVSAMLIASKYEEIGPPKVEDF 198
Cdd:cd20543   6 IDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDL 72
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 234-350 2.43e-07

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 49.11  E-value: 2.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 234 FLRRFTRVAQEDFKDSQLqieflCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIrpKQHPWNQMLEEYTKYKAADLQ 313
Cdd:cd20570   6 FLRRASKAGSADVEKHTL-----AKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVL--DGGKWSLTQQYYTGYTEDDLK 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15220147 314 VCVGIIHDLYLSRRGNTLE--AVRNKYKQHKYKCVATMP 350
Cdd:cd20570  79 PIMQHMAKNVVKVNEGLTKhvAVKNKYASSKLMKISTIP 117
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 234-350 7.11e-07

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 47.58  E-value: 7.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 234 FLRRFTRVAQEDfkdsqLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLARFIIRPKQhpWNQMLEEYTKYKAADL- 312
Cdd:cd20569   6 FLRRASKIGEVD-----VEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGE--WTPTLQHYMSYTEESLl 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15220147 313 QVCVGIIHDLYLSRRGNTLE-AVRNKYKQHKYKCVATMP 350
Cdd:cd20569  79 PVMQHMAKNVVKVNQGLTKHmTVKNKYASSKQMKISTLP 117
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 135-226 1.16e-06

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 46.54  E-value: 1.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 135 VDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKYEE----IgpPKVEDFCYITDNTFTKQE 210
Cdd:cd20526   6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSVAE 83

                        90
                ....*....|....*.
gi 15220147 211 VVSMEADILLALQFEL 226
Cdd:cd20526  84 VLRMERIILDKLHWDL 99
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 229-323 9.76e-05

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 40.79  E-value: 9.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRV----AQEDFKDSQLQIEFLCCYLSELSMLDYTCVKYLPSLLSASAVFLArfiIRPKQH--PWNQMLE 302
Cdd:cd20722   1 PTLQFFLEHFSSLrlenRELSCAEEARKARALARYLAELSLADYAFNQYPPSLLAICSLELA---DRMLQHrsPITERLS 77

                        90       100
                ....*....|....*....|.
gi 15220147 303 EYTkykAADLQVCVGIIHDLY 323
Cdd:cd20722  78 GYP---QSALEDCVGKLRLLV 95
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 145-219 1.41e-04

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 40.41  E-value: 1.41e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15220147 145 YKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKY--EEIGPPKVEDFCYITDNTFTKQEVVSMEADIL 219
Cdd:cd20523  15 YGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRMEGIIL 91
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 134-224 1.58e-04

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 40.33  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 134 LVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVG----VSAMLIASKYEEIGPPKVEDFCYITDntFTKQ 209
Cdd:cd20557   2 LRSFIARLLRRTRLSPSVVLLALVYLERLRRRLPEALLGQEGSPyrlfLVALMLASKYLDDESYSNKSWAEISG--LPVR 79

                        90
                ....*....|....*
gi 15220147 210 EVVSMEADILLALQF 224
Cdd:cd20557  80 ELNAMEREFLEALDW 94
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 130-219 3.83e-04

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 39.42  E-value: 3.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 130 MRAVLVDWLVEVAEEYKLVSDTLYLTISYVDRFLSVKPINRQKLQLVGVSAMLIASKY--EEIGPPKVEDFCYITDNTFT 207
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|..
gi 15220147 208 KQEVVSMEADIL 219
Cdd:cd20583  81 VSDMMRMEKIIL 92
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 229-316 1.91e-03

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 37.26  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDFKDSQLQIEFLC-----------CYLSELSMLDYTCVKYLPSLLSASAVFLarfIIRPKQHpw 297
Cdd:cd20520   2 PTPNSWLNLYLQLAQLNPPPKENDSAFLLpqysldrfvraAQLLDLCILDIGSLQFSYSVLAASALYL---VSPDDEA-- 76

                        90
                ....*....|....*....
gi 15220147 298 nqmLEEYTKYKAADLQVCV 316
Cdd:cd20520  77 ---IEQVTGYSWEQLAPCV 92
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 229-324 8.10e-03

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 35.57  E-value: 8.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220147 229 PTIKTFLRRFTRVAQEDFKDSQLQIEFLCC--YLSELSMLDYTCVKYLPSLLSASAVFLARFIIRPKQHPWNQMLEEY-- 304
Cdd:cd20721   1 PTILTFLRMYIERLSLESGAAHASRPLERLamFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNRPAAWAAEALSAEla 80

                        90       100
                ....*....|....*....|...
gi 15220147 305 ---TKYKAADLQVCVGIIHDLYL 324
Cdd:cd20721  81 avlVHTRAPEVLRCVQALHQLVG 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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