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Conserved domains on  [gi|145336554|ref|NP_175377|]
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elongator protein 2 [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-441 1.97e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 1.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  54 TLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnndwRHVLQLPLSHKKGVTCITAYMVSETda 133
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-----------DGKLLATGSGDGTIKVWDLET-----GELLRTLKGHTGPVRDVAASADGTY-- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 134 mFASASSDGVVNVWDVSfpsqpseecKVVCLDSICVDTKAIVTLSLaelpqNPGRFALALGGLDNKIKLYSGErTGKFTS 213
Cdd:cd00200   66 -LASGSSDKTIRLWDLE---------TGECVRTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVE-TGKCLT 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 214 VceLKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlvgDVGSWRREITLAsyiegpvfvsgtftyqis 293
Cdd:cd00200  130 T--LRGHTDWVNSVAFS---------PDGTFVASSSQDGTIKLW------DLRTGKCVATLT------------------ 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 294 vesvliGHEDWVYSVEWQPpvidfiDGRlvnhqplSILSASMDKTMMIWRPEKKTgvwvnvvCVGELSHCALGFYGGHWS 373
Cdd:cd00200  175 ------GHTGEVNSVAFSP------DGE-------KLLSSSSDGTIKLWDLSTGK-------CLGTLRGHENGVNSVAFS 228

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145336554 374 PNSLSILAHGYGGAFHLWRnvssskeSENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFS 441
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWD-------LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
297-748 7.06e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 7.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 297 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 376
Cdd:COG2319   73 TLLGHTAAVLSVAFSP------DGRL-------LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA-------FSPDG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 377 LSILAHGYGGAFHLWrnvssskESENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 456
Cdd:COG2319  133 KTLASGSADGTVRLW-------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGKL------ 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 457 heLARPQVHGHDINCVAMvqGKGNHRFVSGAEEKVVRVFEAPlsflktlnhtcaggegsfpedlqadvqvlganmsalgl 536
Cdd:COG2319  197 --LRTLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLA-------------------------------------- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 537 sqkpiylhssseplerngGGEGLDTFEtvpeaapaelkeppiedqlafhtlwpeshklyGHGNELFSLCSDHKGNLVASS 616
Cdd:COG2319  235 ------------------TGKLLRTLT--------------------------------GHSGSVRSVAFSPDGRLLASG 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 617 CKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQrtdngevSHKLMAKVEAHKRI 696
Cdd:COG2319  265 SADGT-----VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRTLTGHTGA 332

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145336554 697 IWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWT 748
Cdd:COG2319  333 VRSVAFSPDGKTLASGSDDGTVRLWDLATG---ELLRTLTGHTGAVTSVAFS 381
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-441 1.97e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 1.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  54 TLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnndwRHVLQLPLSHKKGVTCITAYMVSETda 133
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-----------DGKLLATGSGDGTIKVWDLET-----GELLRTLKGHTGPVRDVAASADGTY-- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 134 mFASASSDGVVNVWDVSfpsqpseecKVVCLDSICVDTKAIVTLSLaelpqNPGRFALALGGLDNKIKLYSGErTGKFTS 213
Cdd:cd00200   66 -LASGSSDKTIRLWDLE---------TGECVRTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVE-TGKCLT 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 214 VceLKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlvgDVGSWRREITLAsyiegpvfvsgtftyqis 293
Cdd:cd00200  130 T--LRGHTDWVNSVAFS---------PDGTFVASSSQDGTIKLW------DLRTGKCVATLT------------------ 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 294 vesvliGHEDWVYSVEWQPpvidfiDGRlvnhqplSILSASMDKTMMIWRPEKKTgvwvnvvCVGELSHCALGFYGGHWS 373
Cdd:cd00200  175 ------GHTGEVNSVAFSP------DGE-------KLLSSSSDGTIKLWDLSTGK-------CLGTLRGHENGVNSVAFS 228

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145336554 374 PNSLSILAHGYGGAFHLWRnvssskeSENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFS 441
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWD-------LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-442 3.73e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 3.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  25 VSWGASGLVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnn 104
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-----------DGKTLASGSADGTVRLWDLAT--- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 105 dwRHVLQLPLSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTLSLAelPQ 184
Cdd:COG2319  152 --GKLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGK---------LLRTLTGHTGAVRSVAFS--PD 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 185 npGRFaLALGGLDNKIKLYSGErTGKFtsVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlvgD 264
Cdd:COG2319  216 --GKL-LASGSADGTVRLWDLA-TGKL--LRTLTGHSGSVRSVAFS---------PDGRLLASGSADGTVRLW------D 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 265 VGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRP 344
Cdd:COG2319  275 LATGELLRTLT------------------------GHSGGVNSVAFSP------DGKL-------LASGSDDGTVRLWDL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 345 EKKTgvwvnvvCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWrNVSSSKESENWQmqkvpsGHFAAVTDVTWART 424
Cdd:COG2319  318 ATGK-------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW-DLATGELLRTLT------GHTGAVTSVAFSPD 383

                        410
                 ....*....|....*...
gi 145336554 425 GEYLLSVSQDQTTRVFSA 442
Cdd:COG2319  384 GRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
297-748 7.06e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 7.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 297 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 376
Cdd:COG2319   73 TLLGHTAAVLSVAFSP------DGRL-------LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA-------FSPDG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 377 LSILAHGYGGAFHLWrnvssskESENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 456
Cdd:COG2319  133 KTLASGSADGTVRLW-------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGKL------ 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 457 heLARPQVHGHDINCVAMvqGKGNHRFVSGAEEKVVRVFEAPlsflktlnhtcaggegsfpedlqadvqvlganmsalgl 536
Cdd:COG2319  197 --LRTLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLA-------------------------------------- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 537 sqkpiylhssseplerngGGEGLDTFEtvpeaapaelkeppiedqlafhtlwpeshklyGHGNELFSLCSDHKGNLVASS 616
Cdd:COG2319  235 ------------------TGKLLRTLT--------------------------------GHSGSVRSVAFSPDGRLLASG 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 617 CKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQrtdngevSHKLMAKVEAHKRI 696
Cdd:COG2319  265 SADGT-----VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRTLTGHTGA 332

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145336554 697 IWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWT 748
Cdd:COG2319  333 VRSVAFSPDGKTLASGSDDGTVRLWDLATG---ELLRTLTGHTGAVTSVAFS 381
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 297-722 1.60e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 1.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 297 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 376
Cdd:cd00200    4 TLKGHTGGVTCVAFSP------DGKL-------LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-------ASADG 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 377 LSILAHGYGGAFHLWrNVSSSKESENWQmqkvpsGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 456
Cdd:cd00200   64 TYLASGSSDKTIRLW-DLETGECVRTLT------GHTSYVSSVAFSPDGRILSSSSRDKTIKV---WDVETGKC------ 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 457 heLARPQVHGHDINCVAMvqgKGNHRFVSGA-EEKVVRVFEaplsflktlnhtcaggegsfpedlqadvqvlganmsalg 535
Cdd:cd00200  128 --LTTLRGHTDWVNSVAF---SPDGTFVASSsQDGTIKLWD--------------------------------------- 163

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 536 lsqkpiylhssseplerngggegLDTFETVpeaapaelkeppiedqlafhtlwpesHKLYGHGNELFSLCSDHKGNLVAS 615
Cdd:cd00200  164 -----------------------LRTGKCV--------------------------ATLTGHTGEVNSVAFSPDGEKLLS 194

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 616 SckaqsASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFsiqRTDNGEVSHKLmakvEAHKR 695
Cdd:cd00200  195 S-----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW---DLRTGECVQTL----SGHTN 262

                        410       420
                 ....*....|....*....|....*..
gi 145336554 696 IIWACSWNPFGHQFATSSRDKTVKIWS 722
Cdd:cd00200  263 SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 683-722 1.17e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.17e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 145336554   683 SHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWS 722
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 87-353 2.54e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  87 SGDSDGIIILWELStlnndwRHVLQLPL-SHKKGVTCITaymVSETD-AMFASASSDGVVNVWDVSfpsqpseecKVVCL 164
Cdd:PLN00181 550 SSNFEGVVQVWDVA------RSQLVTEMkEHEKRVWSID---YSSADpTLLASGSDDGSVKLWSIN---------QGVSI 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 165 DSIcvDTKAivTLSLAELPQNPGRfALALGGLDNKIKLYSgERTGKFtSVCELKGHTDWIRSLDFSlplhtteeipNSIM 244
Cdd:PLN00181 612 GTI--KTKA--NICCVQFPSESGR-SLAFGSADHKVYYYD-LRNPKL-PLCTMIGHSKTVSYVRFV----------DSST 674

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 245 LVSSSQDKVIRIWKLVLvgdVGSWRREITLASYIeGPVFVSGTFTYQISVESVLIGHED---WVYSVEWQPPVIDFIDGR 321
Cdd:PLN00181 675 LVSSSTDNTLKLWDLSM---SISGINETPLHSFM-GHTNVKNFVGLSVSDGYIATGSETnevFVYHKAFPMPVLSYKFKT 750

                        250       260       270
                 ....*....|....*....|....*....|..
gi 145336554 322 LVNHQPLSILSASMDKTMMIWRPEKKTGVWVN 353
Cdd:PLN00181 751 IDPVSGLEVDDASQFISSVCWRGQSSTLVAAN 782
WD40 pfam00400
WD domain, G-beta repeat;
685-722 9.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 9.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 145336554  685 KLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWS 722
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 210-258 2.56e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 145336554   210 KFTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWK 258
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS---------PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
211-257 8.60e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 8.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 145336554  211 FTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIW 257
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS---------PDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 638-742 1.93e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 638 VGRLQSHSLTVTHLEFS--YDDtLLLSVSRDRHFSVFSIQRTDNG--EVSHKLMAkVEAHKRIIWACSWNPFGHQFATSS 713
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNpcFSE-ILASGSEDLTIRVWEIPHNDESvkEIKDPQCI-LKGHKKKISIIDWNPMNYYIMCSS 144

                         90       100       110
                 ....*....|....*....|....*....|
gi 145336554 714 R-DKTVKIWSVENDARIKQIlVLPPFGSSV 742
Cdd:PTZ00420 145 GfDSFVNIWDIENEKRAFQI-NMPKKLSSL 173
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-441 1.97e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 1.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  54 TLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnndwRHVLQLPLSHKKGVTCITAYMVSETda 133
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-----------DGKLLATGSGDGTIKVWDLET-----GELLRTLKGHTGPVRDVAASADGTY-- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 134 mFASASSDGVVNVWDVSfpsqpseecKVVCLDSICVDTKAIVTLSLaelpqNPGRFALALGGLDNKIKLYSGErTGKFTS 213
Cdd:cd00200   66 -LASGSSDKTIRLWDLE---------TGECVRTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVE-TGKCLT 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 214 VceLKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlvgDVGSWRREITLAsyiegpvfvsgtftyqis 293
Cdd:cd00200  130 T--LRGHTDWVNSVAFS---------PDGTFVASSSQDGTIKLW------DLRTGKCVATLT------------------ 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 294 vesvliGHEDWVYSVEWQPpvidfiDGRlvnhqplSILSASMDKTMMIWRPEKKTgvwvnvvCVGELSHCALGFYGGHWS 373
Cdd:cd00200  175 ------GHTGEVNSVAFSP------DGE-------KLLSSSSDGTIKLWDLSTGK-------CLGTLRGHENGVNSVAFS 228

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145336554 374 PNSLSILAHGYGGAFHLWRnvssskeSENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFS 441
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWD-------LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-442 3.73e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 3.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  25 VSWGASGLVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnn 104
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-----------DGKTLASGSADGTVRLWDLAT--- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 105 dwRHVLQLPLSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTLSLAelPQ 184
Cdd:COG2319  152 --GKLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGK---------LLRTLTGHTGAVRSVAFS--PD 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 185 npGRFaLALGGLDNKIKLYSGErTGKFtsVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlvgD 264
Cdd:COG2319  216 --GKL-LASGSADGTVRLWDLA-TGKL--LRTLTGHSGSVRSVAFS---------PDGRLLASGSADGTVRLW------D 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 265 VGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRP 344
Cdd:COG2319  275 LATGELLRTLT------------------------GHSGGVNSVAFSP------DGKL-------LASGSDDGTVRLWDL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 345 EKKTgvwvnvvCVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWrNVSSSKESENWQmqkvpsGHFAAVTDVTWART 424
Cdd:COG2319  318 ATGK-------LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW-DLATGELLRTLT------GHTGAVTSVAFSPD 383

                        410
                 ....*....|....*...
gi 145336554 425 GEYLLSVSQDQTTRVFSA 442
Cdd:COG2319  384 GRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
22-345 7.83e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 7.83e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  22 VNNVSWGASG--LVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWEL 99
Cdd:COG2319  165 VTSVAFSPDGklLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-----------DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 100 STlnndwRHVLQLPLSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTLSL 179
Cdd:COG2319  234 AT-----GKLLRTLTGHSGSVRSVA---FSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGGVNSVAF 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 180 AelpqnP-GRFaLALGGLDNKIKLYSGErTGKftSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWk 258
Cdd:COG2319  297 S-----PdGKL-LASGSDDGTVRLWDLA-TGK--LLRTLTGHTGAVRSVAFS---------PDGKTLASGSDDGTVRLW- 357

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 259 lvlvgDVGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKT 338
Cdd:COG2319  358 -----DLATGELLRTLT------------------------GHTGAVTSVAFSP------DGRT-------LASGSADGT 395


                 ....*..
gi 145336554 339 MMIWRPE 345
Cdd:COG2319  396 VRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
25-497 1.15e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 1.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  25 VSWGASGLVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnn 104
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-----------DGRLLASASADGTVRLWDLAT--- 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 105 dwRHVLQLPLSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTLSLAelPQ 184
Cdd:COG2319  110 --GLLLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLATGK---------LLRTLTGHSGAVTSVAFS--PD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 185 npGRFaLALGGLDNKIKLYSGeRTGKFTSVceLKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlvgD 264
Cdd:COG2319  174 --GKL-LASGSDDGTVRLWDL-ATGKLLRT--LTGHTGAVRSVAFS---------PDGKLLASGSADGTVRLW------D 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 265 VGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRP 344
Cdd:COG2319  233 LATGKLLRTLT------------------------GHSGSVRSVAFSP------DGRL-------LASGSADGTVRLWDL 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 345 EkktgvwvnvvcvgelshcalgfygghwspnslsilahgyggafhlwrnvssskeseNWQMQKVPSGHFAAVTDVTWART 424
Cdd:COG2319  276 A--------------------------------------------------------TGELLRTLTGHSGGVNSVAFSPD 299

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145336554 425 GEYLLSVSQDQTTRVFSAwkndegneaedEHWHELARPQVHGHDINCVAMVQgkGNHRFVSGAEEKVVRVFEA 497
Cdd:COG2319  300 GKLLASGSDDGTVRLWDL-----------ATGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
85-725 6.65e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 6.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  85 LLSGDSDGIIILWELSTLNNDWRHVLQLPLSHKKGVTCITAYMVSETDAMFASASSDGVVNVWDVsfpsqpseeckvvcL 164
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA--------------A 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 165 DSICVDTKAIVTLSLAELPQNPGRFALALGGLDNKIKLYSGERTgkfTSVCELKGHTDWIRSLDFSlplhtteeiPNSIM 244
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFS---------PDGKT 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 245 LVSSSQDKVIRIWklvlvgDVGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvn 324
Cdd:COG2319  135 LASGSADGTVRLW------DLATGKLLRTLT------------------------GHSGAVTSVAFSP------DGKL-- 176

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 325 hqplsILSASMDKTMMIWRPEKktgvwvnvvcvGELSHcalgfygghwspnslsilahgyggafhlwrnvssskesenwq 404
Cdd:COG2319  177 -----LASGSDDGTVRLWDLAT-----------GKLLR------------------------------------------ 198

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 405 mqkVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAwkndegneaedEHWHELARPQVHGHDINCVAM-VQGKgnhRF 483
Cdd:COG2319  199 ---TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-----------ATGKLLRTLTGHSGSVRSVAFsPDGR---LL 261

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 484 VSGAEEKVVRVFeaplsflktlnhtcaggegsfpedlqaDVQvlganmsalglsqkpiylhssseplerngGGEGLDTFE 563
Cdd:COG2319  262 ASGSADGTVRLW---------------------------DLA-----------------------------TGELLRTLT 285

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 564 tvpeaapaelkeppiedqlafhtlwpeshklyGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQS 643
Cdd:COG2319  286 --------------------------------GHSGGVNSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTG 328

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 644 HSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIqrtDNGEVSHKLmakvEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSV 723
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTL----TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401


                 ..
gi 145336554 724 EN 725
Cdd:COG2319  402 AT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 32-258 8.31e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.41  E-value: 8.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  32 LVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPTSKFafkakkldrqyLLSGDSDGIIILWELSTlnndWRHVLQ 111
Cdd:cd00200  108 LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF-----------VASSSQDGTIKLWDLRT----GKCVAT 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 112 LPlSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTLSLaelpqNPGRFAL 191
Cdd:cd00200  173 LT-GHTGEVNSVA---FSPDGEKLLSSSSDGTIKLWDLSTGK---------CLGTLRGHENGVNSVAF-----SPDGYLL 234

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145336554 192 ALGGLDNKIKLYSGErtgKFTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWK 258
Cdd:cd00200  235 ASGSEDGTIRVWDLR---TGECVQTLSGHTNSVTSLAWS---------PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
297-748 7.06e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 7.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 297 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 376
Cdd:COG2319   73 TLLGHTAAVLSVAFSP------DGRL-------LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA-------FSPDG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 377 LSILAHGYGGAFHLWrnvssskESENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 456
Cdd:COG2319  133 KTLASGSADGTVRLW-------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGKL------ 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 457 heLARPQVHGHDINCVAMvqGKGNHRFVSGAEEKVVRVFEAPlsflktlnhtcaggegsfpedlqadvqvlganmsalgl 536
Cdd:COG2319  197 --LRTLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLA-------------------------------------- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 537 sqkpiylhssseplerngGGEGLDTFEtvpeaapaelkeppiedqlafhtlwpeshklyGHGNELFSLCSDHKGNLVASS 616
Cdd:COG2319  235 ------------------TGKLLRTLT--------------------------------GHSGSVRSVAFSPDGRLLASG 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 617 CKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQrtdngevSHKLMAKVEAHKRI 696
Cdd:COG2319  265 SADGT-----VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRTLTGHTGA 332

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145336554 697 IWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWT 748
Cdd:COG2319  333 VRSVAFSPDGKTLASGSDDGTVRLWDLATG---ELLRTLTGHTGAVTSVAFS 381
WD40 COG2319
WD40 repeat [General function prediction only];
592-835 2.83e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 2.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 592 HKLYGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSV 671
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTLASGSADGT-----VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 672 FSIQrtdngevSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWTGLD 751
Cdd:COG2319  189 WDLA-------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDG 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 752 RneksgCVAVGMESGLIELSNVkiieteegttATAALALRLEPfmcHVSAVNRLAWRPTEkcesnqslRWLTSCGDDNCV 831
Cdd:COG2319  259 R-----LLASGSADGTVRLWDL----------ATGELLRTLTG---HSGGVNSVAFSPDG--------KLLASGSDDGTV 312


                 ....
gi 145336554 832 RVFN 835
Cdd:COG2319  313 RLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
592-835 1.50e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.50e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 592 HKLYGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSV 671
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 672 FSIQRTdngevshKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKqilVLPPFGSSVTAVAWTGLD 751
Cdd:COG2319  231 WDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---TLTGHSGGVNSVAFSPDG 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 752 RNeksgcVAVGMESGLIELSNVkiieteegttATAALALRLEPfmcHVSAVNRLAWRPTEkcesnqslRWLTSCGDDNCV 831
Cdd:COG2319  301 KL-----LASGSDDGTVRLWDL----------ATGKLLRTLTG---HTGAVRSVAFSPDG--------KTLASGSDDGTV 354


                 ....
gi 145336554 832 RVFN 835
Cdd:COG2319  355 RLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 297-722 1.60e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 1.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 297 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 376
Cdd:cd00200    4 TLKGHTGGVTCVAFSP------DGKL-------LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-------ASADG 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 377 LSILAHGYGGAFHLWrNVSSSKESENWQmqkvpsGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 456
Cdd:cd00200   64 TYLASGSSDKTIRLW-DLETGECVRTLT------GHTSYVSSVAFSPDGRILSSSSRDKTIKV---WDVETGKC------ 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 457 heLARPQVHGHDINCVAMvqgKGNHRFVSGA-EEKVVRVFEaplsflktlnhtcaggegsfpedlqadvqvlganmsalg 535
Cdd:cd00200  128 --LTTLRGHTDWVNSVAF---SPDGTFVASSsQDGTIKLWD--------------------------------------- 163

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 536 lsqkpiylhssseplerngggegLDTFETVpeaapaelkeppiedqlafhtlwpesHKLYGHGNELFSLCSDHKGNLVAS 615
Cdd:cd00200  164 -----------------------LRTGKCV--------------------------ATLTGHTGEVNSVAFSPDGEKLLS 194

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 616 SckaqsASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFsiqRTDNGEVSHKLmakvEAHKR 695
Cdd:cd00200  195 S-----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW---DLRTGECVQTL----SGHTN 262

                        410       420
                 ....*....|....*....|....*..
gi 145336554 696 IIWACSWNPFGHQFATSSRDKTVKIWS 722
Cdd:cd00200  263 SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 590-835 1.08e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 1.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 590 ESHKLYGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHF 669
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-----IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 670 SVFSIQrtdngevSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWTG 749
Cdd:cd00200  160 KLWDLR-------TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---KCLGTLRGHENGVNSVAFSP 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 750 LDRNeksgcVAVGMESGLIelsnvKIIETEEGTTataalalrLEPFMCHVSAVNRLAWRPTEKcesnqslrWLTSCGDDN 829
Cdd:cd00200  230 DGYL-----LASGSEDGTI-----RVWDLRTGEC--------VQTLSGHTNSVTSLAWSPDGK--------RLASGSADG 283


                 ....*.
gi 145336554 830 CVRVFN 835
Cdd:cd00200  284 TIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 590-837 1.41e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 590 ESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMaeiwlWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHF 669
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKV-----WDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 670 SVFSIQrtdNGEVSHKLmakvEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWTG 749
Cdd:cd00200   76 RLWDLE---TGECVRTL----TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 750 LDRneksgCVAVGMESGLI---ELSNVKIIETEEGttataalalrlepfmcHVSAVNRLAWRPTEkcesnqslRWLTSCG 826
Cdd:cd00200  146 DGT-----FVASSSQDGTIklwDLRTGKCVATLTG----------------HTGEVNSVAFSPDG--------EKLLSSS 196

                        250
                 ....*....|.
gi 145336554 827 DDNCVRVFNFK 837
Cdd:cd00200  197 SDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
619-835 2.31e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 2.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 619 AQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQrtdngevSHKLMAKVEAHKRIIW 698
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA-------TGLLLRTLTGHTGAVR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 699 ACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWTGLDRNeksgcVAVGMESGLIELSNVkiiet 778
Cdd:COG2319  125 SVAFSPDGKTLASGSADGTVRLWDLATG---KLLRTLTGHSGAVTSVAFSPDGKL-----LASGSDDGTVRLWDL----- 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145336554 779 eegttATAALALRLEPfmcHVSAVNRLAWRPTEkcesnqslRWLTSCGDDNCVRVFN 835
Cdd:COG2319  192 -----ATGKLLRTLTG---HTGAVRSVAFSPDG--------KLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 592-837 1.63e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 1.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 592 HKLYGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSV 671
Cdd:cd00200   45 RTLKGHTGPVRDVAASADGTYLASGSSDKT-----IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 672 FSIQRTdngevshKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKqilVLPPFGSSVTAVAWTGld 751
Cdd:cd00200  120 WDVETG-------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA---TLTGHTGEVNSVAFSP-- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 752 rneKSGCVAVGMESGlielsNVKIIETEEGTTataalalrLEPFMCHVSAVNRLAWrptekcesNQSLRWLTSCGDDNCV 831
Cdd:cd00200  188 ---DGEKLLSSSSDG-----TIKLWDLSTGKC--------LGTLRGHENGVNSVAF--------SPDGYLLASGSEDGTI 243


                 ....*.
gi 145336554 832 RVFNFK 837
Cdd:cd00200  244 RVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
10-150 1.40e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  10 KRVFIGAGCNRVVNNVSWGASG--LVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLS 87
Cdd:COG2319  279 ELLRTLTGHSGGVNSVAFSPDGklLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-----------DGKTLAS 347

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145336554  88 GDSDGIIILWELSTlnndwRHVLQLPLSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVS 150
Cdd:COG2319  348 GSDDGTVRLWDLAT-----GELLRTLTGHTGAVTSVA---FSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
619-835 6.47e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 6.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 619 AQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTdngevshKLMAKVEAHKRIIW 698
Cdd:COG2319   10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-------ALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 699 ACSWNPFGHQFATSSRDKTVKIWSVENDARIKQilvLPPFGSSVTAVAWTgldRNEKSgcVAVGMESGlielsNVKIIET 778
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRT---LTGHTGAVRSVAFS---PDGKT--LASGSADG-----TVRLWDL 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145336554 779 EEGTtataalalRLEPFMCHVSAVNRLAWRPTEKcesnqslrWLTSCGDDNCVRVFN 835
Cdd:COG2319  150 ATGK--------LLRTLTGHSGAVTSVAFSPDGK--------LLASGSDDGTVRLWD 190
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 683-722 1.17e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.17e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 145336554   683 SHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWS 722
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 87-353 2.54e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  87 SGDSDGIIILWELStlnndwRHVLQLPL-SHKKGVTCITaymVSETD-AMFASASSDGVVNVWDVSfpsqpseecKVVCL 164
Cdd:PLN00181 550 SSNFEGVVQVWDVA------RSQLVTEMkEHEKRVWSID---YSSADpTLLASGSDDGSVKLWSIN---------QGVSI 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 165 DSIcvDTKAivTLSLAELPQNPGRfALALGGLDNKIKLYSgERTGKFtSVCELKGHTDWIRSLDFSlplhtteeipNSIM 244
Cdd:PLN00181 612 GTI--KTKA--NICCVQFPSESGR-SLAFGSADHKVYYYD-LRNPKL-PLCTMIGHSKTVSYVRFV----------DSST 674

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 245 LVSSSQDKVIRIWKLVLvgdVGSWRREITLASYIeGPVFVSGTFTYQISVESVLIGHED---WVYSVEWQPPVIDFIDGR 321
Cdd:PLN00181 675 LVSSSTDNTLKLWDLSM---SISGINETPLHSFM-GHTNVKNFVGLSVSDGYIATGSETnevFVYHKAFPMPVLSYKFKT 750

                        250       260       270
                 ....*....|....*....|....*....|..
gi 145336554 322 LVNHQPLSILSASMDKTMMIWRPEKKTGVWVN 353
Cdd:PLN00181 751 IDPVSGLEVDDASQFISSVCWRGQSSTLVAAN 782
WD40 pfam00400
WD domain, G-beta repeat;
685-722 9.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 9.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 145336554  685 KLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWS 722
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 210-258 2.56e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 145336554   210 KFTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWK 258
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS---------PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
211-257 8.60e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 8.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 145336554  211 FTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIW 257
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS---------PDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
22-101 1.10e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554  22 VNNVSWGASG--LVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWEL 99
Cdd:COG2319  333 VRSVAFSPDGktLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-----------DGRTLASGSADGTVRLWDL 401


                 ..
gi 145336554 100 ST 101
Cdd:COG2319  402 AT 403
PTZ00420 PTZ00420
coronin; Provisional
 638-742 1.93e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145336554 638 VGRLQSHSLTVTHLEFS--YDDtLLLSVSRDRHFSVFSIQRTDNG--EVSHKLMAkVEAHKRIIWACSWNPFGHQFATSS 713
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNpcFSE-ILASGSEDLTIRVWEIPHNDESvkEIKDPQCI-LKGHKKKISIIDWNPMNYYIMCSS 144

                         90       100       110
                 ....*....|....*....|....*....|
gi 145336554 714 R-DKTVKIWSVENDARIKQIlVLPPFGSSV 742
Cdd:PTZ00420 145 GfDSFVNIWDIENEKRAFQI-NMPKKLSSL 173
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 48-98 5.89e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 145336554    48 TAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWE 98
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-----------DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
50-98 9.23e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 9.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 145336554   50 QILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWE 98
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-----------DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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