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Conserved domains on  [gi|42562675|ref|NP_175550|]
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NFU domain protein 5 [Arabidopsis thaliana]

Protein Classification

NifU family protein( domain architecture ID 10658661)

NifU family protein may play a role in the biogenesis of Fe/S proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 77-163 5.57e-41

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


:

Pssm-ID: 214919  Cd Length: 88  Bit Score: 136.50  E-value: 5.57e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675     77 IQTQSTPNPSSLMFSPGKPVMEIGSADFPNSRSAMS-SPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAV 155
Cdd:smart00932   1 IQTEPTPNPNTLKFLPGEFVLPGGSAEFKSADEAAEaSPLAQKLFEIPGVKSVFFGPDFITVTKYPDVDWEDLKPEVLSV 80


                   ....*...
gi 42562675    156 VMDFYSSG 163
Cdd:smart00932  81 IMEHFESG 88
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 83-260 2.09e-40

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 137.86  E-value: 2.09e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675  83 PNPSSLMFSPGKPVMEIGSADFPNSRSAMSSPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAVVMDFYSS 162
Cdd:COG0694   1 AQAAALKLLPEEPGGELIRGEVAAPGAPAAAALLLAEAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675 163 GQPLFLDSQATAAKDTAIHEDDSETVAMIKELLETRIRPSVQDDGGDIEYCGFdtETGIVKLRMQGACSGCPSSSVTLKS 242
Cdd:COG0694  81 QLTLAAPDAAVAEVLSFHALTDAELEERIEEVLDEEIRPALASDGGDIELVDV--EDGVVYVRLGGACSGCPSSTMTLKN 158

                       170
                ....*....|....*...
gi 42562675 243 GIENMLMHYVSEVKGVEQ 260
Cdd:COG0694 159 GIERALKERVPEVKEVEA 176
 
Name Accession Description Interval E-value
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 77-163 5.57e-41

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 214919  Cd Length: 88  Bit Score: 136.50  E-value: 5.57e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675     77 IQTQSTPNPSSLMFSPGKPVMEIGSADFPNSRSAMS-SPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAV 155
Cdd:smart00932   1 IQTEPTPNPNTLKFLPGEFVLPGGSAEFKSADEAAEaSPLAQKLFEIPGVKSVFFGPDFITVTKYPDVDWEDLKPEVLSV 80


                   ....*...
gi 42562675    156 VMDFYSSG 163
Cdd:smart00932  81 IMEHFESG 88
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 83-260 2.09e-40

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 137.86  E-value: 2.09e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675  83 PNPSSLMFSPGKPVMEIGSADFPNSRSAMSSPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAVVMDFYSS 162
Cdd:COG0694   1 AQAAALKLLPEEPGGELIRGEVAAPGAPAAAALLLAEAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675 163 GQPLFLDSQATAAKDTAIHEDDSETVAMIKELLETRIRPSVQDDGGDIEYCGFdtETGIVKLRMQGACSGCPSSSVTLKS 242
Cdd:COG0694  81 QLTLAAPDAAVAEVLSFHALTDAELEERIEEVLDEEIRPALASDGGDIELVDV--EDGVVYVRLGGACSGCPSSTMTLKN 158

                       170
                ....*....|....*...
gi 42562675 243 GIENMLMHYVSEVKGVEQ 260
Cdd:COG0694 159 GIERALKERVPEVKEVEA 176
Nfu_N pfam08712
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 77-155 5.90e-38

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 462574  Cd Length: 81  Bit Score: 128.36  E-value: 5.90e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675    77 IQTQSTPNPSSLMFSPGKPVMEIG-SADFPNSRSAMSSPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAV 155
Cdd:pfam08712   1 IQTEPTPNPNALKFIPGKPLLPEGgTAEFKSAEEAKASPLAQKLFAIPGVKSVFIGPDFITVTKDDDVDWEDLKPEVRSV 80
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 191-259 1.71e-34

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 119.08  E-value: 1.71e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42562675   191 IKELLETRIRPSVQDDGGDIEYCGFDTetGIVKLRMQGACSGCPSSSVTLKSGIENMLMHYVSEVKGVE 259
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDD--GVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
NifU_proper TIGR02000
Fe-S cluster assembly protein NifU; Three different but partially homologous Fe-S cluster ...
 188-259 2.94e-08

Fe-S cluster assembly protein NifU; Three different but partially homologous Fe-S cluster assembly systems have been described: Isc, Suf, and Nif. The latter is associated with donation of an Fe-S cluster to nitrogenase in a number of nitrogen-fixing species. NifU, described here, consists of an N-terminal domain (pfam01592) and a C-terminal domain (pfam01106). Homologs with an equivalent domain archictecture from Helicobacter and Campylobacter, however, are excluded from this model by a high trusted cutoff. The model, therefore, is specific for NifU involved in nitrogenase maturation. The related model TIGR01999 homologous to the N-terminus of this model describes IscU from the Isc system as in E. coli, Saccharomyces cerevisiae, and Homo sapiens. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Central intermediary metabolism, Nitrogen fixation]


Pssm-ID: 273921 [Multi-domain]  Cd Length: 290  Bit Score: 53.72  E-value: 2.94e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42562675   188 VAMIKELLETrIRPSVQDDGGDIEYcgFDTETGIVKLRMQGACSGCPSSSVTLKsGIENMLMHYVSEVKGVE 259
Cdd:TIGR02000 221 IQLIQKVLEE-VRPVLQADGGDVEL--YDVDGKIVYVVLTGACSGCSMSTMTLK-GIQQRLRERLGEFVVVE 288
PRK11190 PRK11190
iron-sulfur cluster biogenesis protein NfuA;
183-258 4.30e-06

iron-sulfur cluster biogenesis protein NfuA;


Pssm-ID: 183027 [Multi-domain]  Cd Length: 192  Bit Score: 46.16  E-value: 4.30e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562675  183 DDSETVAMIKELLETRIRPSVQDDGGDIEYCGFdTETGIVKLRMQGACSGCPSSSVTLKSGIE-NMLMHYVSEVKGV 258
Cdd:PRK11190 103 DDAPLMERVEYVLQSQINPQLAGHGGRVSLMEI-TEDGYAILQFGGGCNGCSMVDVTLKEGIEkQLLNEFPGELKGV 178
 
Name Accession Description Interval E-value
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 77-163 5.57e-41

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 214919  Cd Length: 88  Bit Score: 136.50  E-value: 5.57e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675     77 IQTQSTPNPSSLMFSPGKPVMEIGSADFPNSRSAMS-SPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAV 155
Cdd:smart00932   1 IQTEPTPNPNTLKFLPGEFVLPGGSAEFKSADEAAEaSPLAQKLFEIPGVKSVFFGPDFITVTKYPDVDWEDLKPEVLSV 80


                   ....*...
gi 42562675    156 VMDFYSSG 163
Cdd:smart00932  81 IMEHFESG 88
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 83-260 2.09e-40

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 137.86  E-value: 2.09e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675  83 PNPSSLMFSPGKPVMEIGSADFPNSRSAMSSPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAVVMDFYSS 162
Cdd:COG0694   1 AQAAALKLLPEEPGGELIRGEVAAPGAPAAAALLLAEAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675 163 GQPLFLDSQATAAKDTAIHEDDSETVAMIKELLETRIRPSVQDDGGDIEYCGFdtETGIVKLRMQGACSGCPSSSVTLKS 242
Cdd:COG0694  81 QLTLAAPDAAVAEVLSFHALTDAELEERIEEVLDEEIRPALASDGGDIELVDV--EDGVVYVRLGGACSGCPSSTMTLKN 158

                       170
                ....*....|....*...
gi 42562675 243 GIENMLMHYVSEVKGVEQ 260
Cdd:COG0694 159 GIERALKERVPEVKEVEA 176
Nfu_N pfam08712
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 77-155 5.90e-38

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 462574  Cd Length: 81  Bit Score: 128.36  E-value: 5.90e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562675    77 IQTQSTPNPSSLMFSPGKPVMEIG-SADFPNSRSAMSSPLAKAIFAIDGVVRVFYGSDFVTVTKSDDVTWDILKPDIFAV 155
Cdd:pfam08712   1 IQTEPTPNPNALKFIPGKPLLPEGgTAEFKSAEEAKASPLAQKLFAIPGVKSVFIGPDFITVTKDDDVDWEDLKPEVRSV 80
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 191-259 1.71e-34

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 119.08  E-value: 1.71e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42562675   191 IKELLETRIRPSVQDDGGDIEYCGFDTetGIVKLRMQGACSGCPSSSVTLKSGIENMLMHYVSEVKGVE 259
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDD--GVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
NifU_proper TIGR02000
Fe-S cluster assembly protein NifU; Three different but partially homologous Fe-S cluster ...
 188-259 2.94e-08

Fe-S cluster assembly protein NifU; Three different but partially homologous Fe-S cluster assembly systems have been described: Isc, Suf, and Nif. The latter is associated with donation of an Fe-S cluster to nitrogenase in a number of nitrogen-fixing species. NifU, described here, consists of an N-terminal domain (pfam01592) and a C-terminal domain (pfam01106). Homologs with an equivalent domain archictecture from Helicobacter and Campylobacter, however, are excluded from this model by a high trusted cutoff. The model, therefore, is specific for NifU involved in nitrogenase maturation. The related model TIGR01999 homologous to the N-terminus of this model describes IscU from the Isc system as in E. coli, Saccharomyces cerevisiae, and Homo sapiens. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Central intermediary metabolism, Nitrogen fixation]


Pssm-ID: 273921 [Multi-domain]  Cd Length: 290  Bit Score: 53.72  E-value: 2.94e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42562675   188 VAMIKELLETrIRPSVQDDGGDIEYcgFDTETGIVKLRMQGACSGCPSSSVTLKsGIENMLMHYVSEVKGVE 259
Cdd:TIGR02000 221 IQLIQKVLEE-VRPVLQADGGDVEL--YDVDGKIVYVVLTGACSGCSMSTMTLK-GIQQRLRERLGEFVVVE 288
PRK11190 PRK11190
iron-sulfur cluster biogenesis protein NfuA;
183-258 4.30e-06

iron-sulfur cluster biogenesis protein NfuA;


Pssm-ID: 183027 [Multi-domain]  Cd Length: 192  Bit Score: 46.16  E-value: 4.30e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42562675  183 DDSETVAMIKELLETRIRPSVQDDGGDIEYCGFdTETGIVKLRMQGACSGCPSSSVTLKSGIE-NMLMHYVSEVKGV 258
Cdd:PRK11190 103 DDAPLMERVEYVLQSQINPQLAGHGGRVSLMEI-TEDGYAILQFGGGCNGCSMVDVTLKEGIEkQLLNEFPGELKGV 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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