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Conserved domains on  [gi|22330441|ref|NP_176760|]
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Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Protein Classification

disease resistance family protein( domain architecture ID 1000118)

disease resistance family protein similar to Nicotiana glutinosa TMV resistance protein N; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein

Gene Ontology:  GO:0006952

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 24-1033 0e+00

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 831.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    24 SSSSSHKWTHQVFPSFRGEDVRRGFLSHIHKEFQRKGITPFIDNEIKRGESIGLEIIHAIRESKIAIVLLSRNYASSSWC 103
Cdd:PLN03210    4 SSSSSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   104 LDELVEIMKCKEEFSQIVIPIFYRVDPSDVKKLTGNFGNVFKNNCVGKTNEVIRKWRQALAKMGTTTGYDSRNWDNEATM 183
Cdd:PLN03210   84 LNELLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKM 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   184 IENIATDISNMLNySTPSRDFDGLIGMRAHMKVMEPMLCLHSDEVRMIGIWGPSGIGKTTIARILFSQFSDSFELSVFME 263
Cdd:PLN03210  164 IEEIANDVLGKLN-LTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFID 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   264 NV---KELMYTRPVCSDEYSAKLHLQKQFMSQIINHKDIEIPHLGVVEDRLKDKKVFIVLDNIDQSIQLDAIAKESRWFG 340
Cdd:PLN03210  243 RAfisKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   341 HGSRIIITTQDRKLLKAHdGINHIYNVNFPSAYEACQIFCMYAFGQKFPKDGFEELAWEVAKLLGGLPLGLRVMGSHFRG 420
Cdd:PLN03210  323 SGSRIIVITKDKHFLRAH-GIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   421 MSKHEWINALPRLRTRLDANIQSILKFSYNALC-EEDKDLFLYIACLFNNKRIEKVEEHLAEKSLNVKQGLHVLTEKSLI 499
Cdd:PLN03210  402 RDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLI 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   500 SIEGGRIKMHNLLEQLGKEIVRhglghQPIREPGKRQFLVDTRDICELLTNDTGSKSVIGIHFYSSELsSELNISERAFE 579
Cdd:PLN03210  482 HVREDIVEMHSLLQEMGKEIVR-----AQSNEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEI-DELHIHENAFK 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   580 GMPNLKFLRFYYRYGDESDKL--YLPQGLNYLSQKLKILEWDHFPLTCMPSNFCTEYLVELNMRFSKLHKLWEGNRPLAN 657
Cdd:PLN03210  556 GMRNLLFLKFYTKKWDQKKEVrwHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTG 635

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   658 LNWMYLNHSKILKELPDLSTatnlqelflvkcsslvelpssigkATNLQKLYLNMCTSLVELPSSIGNLHKLQKLTLNGC 737
Cdd:PLN03210  636 LRNIDLRGSKNLKEIPDLSM------------------------ATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRC 691

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   738 SKLEVLPANINLESLDELDLTDCLVLKRFPEISTNIKVLKLLRTTIKEVPS----------------SIKSWPR------ 795
Cdd:PLN03210  692 ENLEILPTGINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSnlrlenldelilcemkSEKLWERvqpltp 771

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   796 -------------------------------------------------------LRDLELSYNQNLKGFMHALDIITTM 820
Cdd:PLN03210  772 lmtmlspsltrlflsdipslvelpssiqnlhklehleiencinletlptginlesLESLDLSGCSRLRTFPDISTNISDL 851

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   821 YFNDIEMQEIPLWVKKISRLQTLILNGCKKLVSLPQLPDSLSYLKVV---NCESLERLD---------------CSFHNP 882
Cdd:PLN03210  852 NLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVdfsDCGALTEASwngspsevamatdniHSKLPS 931

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   883 KMSLGFINCLKLNKEAKeLIIQITTKCTVLPGREVPVYFTHRTKNGSSLRVNL-NRRPLSTASRFKACILLVNKyckene 961
Cdd:PLN03210  932 TVCINFINCFNLDQEAL-LQQQSIFKQLILSGEEVPSYFTHRTTGASLTNIPLlHISPCQPFFRFRACAVVDSE------ 1004

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   962 vkevfgrkmmkaSYCIIDLGLDVQ--CRPT----HHFLPP---------SLTEHLYIFD----FEADVTS----NELFCD 1018
Cdd:PLN03210 1005 ------------SFFIISVSFDIQvcCRFIdrlgNHFDSPyqphvfsvtKKGSHLVIFDccfpLNEDNAPlaelNYDHVD 1072

                        1130
                  ....*....|....*....
gi 22330441  1019 FQV----DSNEMVIKECGI 1033
Cdd:PLN03210 1073 IQFrltnKNSQLKLKGCGI 1091
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 24-1033 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 831.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    24 SSSSSHKWTHQVFPSFRGEDVRRGFLSHIHKEFQRKGITPFIDNEIKRGESIGLEIIHAIRESKIAIVLLSRNYASSSWC 103
Cdd:PLN03210    4 SSSSSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   104 LDELVEIMKCKEEFSQIVIPIFYRVDPSDVKKLTGNFGNVFKNNCVGKTNEVIRKWRQALAKMGTTTGYDSRNWDNEATM 183
Cdd:PLN03210   84 LNELLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKM 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   184 IENIATDISNMLNySTPSRDFDGLIGMRAHMKVMEPMLCLHSDEVRMIGIWGPSGIGKTTIARILFSQFSDSFELSVFME 263
Cdd:PLN03210  164 IEEIANDVLGKLN-LTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFID 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   264 NV---KELMYTRPVCSDEYSAKLHLQKQFMSQIINHKDIEIPHLGVVEDRLKDKKVFIVLDNIDQSIQLDAIAKESRWFG 340
Cdd:PLN03210  243 RAfisKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   341 HGSRIIITTQDRKLLKAHdGINHIYNVNFPSAYEACQIFCMYAFGQKFPKDGFEELAWEVAKLLGGLPLGLRVMGSHFRG 420
Cdd:PLN03210  323 SGSRIIVITKDKHFLRAH-GIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   421 MSKHEWINALPRLRTRLDANIQSILKFSYNALC-EEDKDLFLYIACLFNNKRIEKVEEHLAEKSLNVKQGLHVLTEKSLI 499
Cdd:PLN03210  402 RDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLI 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   500 SIEGGRIKMHNLLEQLGKEIVRhglghQPIREPGKRQFLVDTRDICELLTNDTGSKSVIGIHFYSSELsSELNISERAFE 579
Cdd:PLN03210  482 HVREDIVEMHSLLQEMGKEIVR-----AQSNEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEI-DELHIHENAFK 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   580 GMPNLKFLRFYYRYGDESDKL--YLPQGLNYLSQKLKILEWDHFPLTCMPSNFCTEYLVELNMRFSKLHKLWEGNRPLAN 657
Cdd:PLN03210  556 GMRNLLFLKFYTKKWDQKKEVrwHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTG 635

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   658 LNWMYLNHSKILKELPDLSTatnlqelflvkcsslvelpssigkATNLQKLYLNMCTSLVELPSSIGNLHKLQKLTLNGC 737
Cdd:PLN03210  636 LRNIDLRGSKNLKEIPDLSM------------------------ATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRC 691

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   738 SKLEVLPANINLESLDELDLTDCLVLKRFPEISTNIKVLKLLRTTIKEVPS----------------SIKSWPR------ 795
Cdd:PLN03210  692 ENLEILPTGINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSnlrlenldelilcemkSEKLWERvqpltp 771

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   796 -------------------------------------------------------LRDLELSYNQNLKGFMHALDIITTM 820
Cdd:PLN03210  772 lmtmlspsltrlflsdipslvelpssiqnlhklehleiencinletlptginlesLESLDLSGCSRLRTFPDISTNISDL 851

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   821 YFNDIEMQEIPLWVKKISRLQTLILNGCKKLVSLPQLPDSLSYLKVV---NCESLERLD---------------CSFHNP 882
Cdd:PLN03210  852 NLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVdfsDCGALTEASwngspsevamatdniHSKLPS 931

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   883 KMSLGFINCLKLNKEAKeLIIQITTKCTVLPGREVPVYFTHRTKNGSSLRVNL-NRRPLSTASRFKACILLVNKyckene 961
Cdd:PLN03210  932 TVCINFINCFNLDQEAL-LQQQSIFKQLILSGEEVPSYFTHRTTGASLTNIPLlHISPCQPFFRFRACAVVDSE------ 1004

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   962 vkevfgrkmmkaSYCIIDLGLDVQ--CRPT----HHFLPP---------SLTEHLYIFD----FEADVTS----NELFCD 1018
Cdd:PLN03210 1005 ------------SFFIISVSFDIQvcCRFIdrlgNHFDSPyqphvfsvtKKGSHLVIFDccfpLNEDNAPlaelNYDHVD 1072

                        1130
                  ....*....|....*....
gi 22330441  1019 FQV----DSNEMVIKECGI 1033
Cdd:PLN03210 1073 IQFrltnKNSQLKLKGCGI 1091
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 33-196 1.19e-63

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 212.61  E-value: 1.19e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441     33 HQVFPSFRGEDVRRGFLSHIHKEFQRKGITPFID-NEIKRGESIGLEIIHAIRESKIAIVLLSRNYASSSWCLDELVEIM 111
Cdd:pfam01582    1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDdRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    112 KCKEEFSQIVIPIFYRVDPSDVKKLTGNFGNVFKNNCVGKTNEVIRKWRQALAKMGTTtgYDSRNWDNEATMIENIATDI 191
Cdd:pfam01582   81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIAYDI 158


                   ....*
gi 22330441    192 SNMLN 196
Cdd:pfam01582  159 SNKLN 163
TIR smart00255
Toll - interleukin 1 - resistance;
32-168 1.84e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 148.63  E-value: 1.84e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441      32 THQVFPSFRG-EDVRRGFLSHIHKEFQRKGITPFIDNEIkRGESIGLEIIHAIRESKIAIVLLSRNYASSSWCLDELVEI 110
Cdd:smart00255    1 EYDVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFE-PGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441     111 MKCKEEF-SQIVIPIFYRVDPSDVKKLTGNFGNVFKNNCVGKTNEVI-RKWRQALAKMGT 168
Cdd:smart00255   80 LENALEEgGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKeQFWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-805 1.65e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 1.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  582 PNLKFLRFYYRYGDESDKLYLPQGLNYLSQKLKILEWDHFPLTCMPSNFCTEYLVELNMRFSKLHKLWEGNRPLANLNWM 661
Cdd:COG4886   62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  662 YLNHSKIlKELPD-LSTATNLQELFLVKCsSLVELPSSIGKATNLQKLYLNmCTSLVELPSSIGNLHKLQKLTLNGCsKL 740
Cdd:COG4886  142 DLSNNQL-TDLPEpLGNLTNLKSLDLSNN-QLTDLPEELGNLTNLKELDLS-NNQITDLPEPLGNLTNLEELDLSGN-QL 217

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22330441  741 EVLPANI-NLESLDELDLTDCLvLKRFPEIS--TNIKVLKLLRTTIKEVPSSIKsWPRLRDLELSYNQ 805
Cdd:COG4886  218 TDLPEPLaNLTNLETLDLSNNQ-LTDLPELGnlTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQ 283
GMPK cd00071
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), ...
 230-260 1.24e-04

Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP). This enzyme is also important for the activation of some antiviral and anticancer agents, such as acyclovir, ganciclovir, carbovir, and thiopurines.


Pssm-ID: 238026  Cd Length: 137  Bit Score: 42.90  E-value: 1.24e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 22330441  230 MIGIWGPSGIGKTTIARILFSQFSDSFELSV 260
Cdd:cd00071    1 LIVLSGPSGVGKSTLLKRLLEEFDPNFGFSV 31
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 24-1033 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 831.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    24 SSSSSHKWTHQVFPSFRGEDVRRGFLSHIHKEFQRKGITPFIDNEIKRGESIGLEIIHAIRESKIAIVLLSRNYASSSWC 103
Cdd:PLN03210    4 SSSSSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   104 LDELVEIMKCKEEFSQIVIPIFYRVDPSDVKKLTGNFGNVFKNNCVGKTNEVIRKWRQALAKMGTTTGYDSRNWDNEATM 183
Cdd:PLN03210   84 LNELLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKM 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   184 IENIATDISNMLNySTPSRDFDGLIGMRAHMKVMEPMLCLHSDEVRMIGIWGPSGIGKTTIARILFSQFSDSFELSVFME 263
Cdd:PLN03210  164 IEEIANDVLGKLN-LTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFID 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   264 NV---KELMYTRPVCSDEYSAKLHLQKQFMSQIINHKDIEIPHLGVVEDRLKDKKVFIVLDNIDQSIQLDAIAKESRWFG 340
Cdd:PLN03210  243 RAfisKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   341 HGSRIIITTQDRKLLKAHdGINHIYNVNFPSAYEACQIFCMYAFGQKFPKDGFEELAWEVAKLLGGLPLGLRVMGSHFRG 420
Cdd:PLN03210  323 SGSRIIVITKDKHFLRAH-GIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRG 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   421 MSKHEWINALPRLRTRLDANIQSILKFSYNALC-EEDKDLFLYIACLFNNKRIEKVEEHLAEKSLNVKQGLHVLTEKSLI 499
Cdd:PLN03210  402 RDKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLI 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   500 SIEGGRIKMHNLLEQLGKEIVRhglghQPIREPGKRQFLVDTRDICELLTNDTGSKSVIGIHFYSSELsSELNISERAFE 579
Cdd:PLN03210  482 HVREDIVEMHSLLQEMGKEIVR-----AQSNEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEI-DELHIHENAFK 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   580 GMPNLKFLRFYYRYGDESDKL--YLPQGLNYLSQKLKILEWDHFPLTCMPSNFCTEYLVELNMRFSKLHKLWEGNRPLAN 657
Cdd:PLN03210  556 GMRNLLFLKFYTKKWDQKKEVrwHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTG 635

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   658 LNWMYLNHSKILKELPDLSTatnlqelflvkcsslvelpssigkATNLQKLYLNMCTSLVELPSSIGNLHKLQKLTLNGC 737
Cdd:PLN03210  636 LRNIDLRGSKNLKEIPDLSM------------------------ATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRC 691

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   738 SKLEVLPANINLESLDELDLTDCLVLKRFPEISTNIKVLKLLRTTIKEVPS----------------SIKSWPR------ 795
Cdd:PLN03210  692 ENLEILPTGINLKSLYRLNLSGCSRLKSFPDISTNISWLDLDETAIEEFPSnlrlenldelilcemkSEKLWERvqpltp 771

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   796 -------------------------------------------------------LRDLELSYNQNLKGFMHALDIITTM 820
Cdd:PLN03210  772 lmtmlspsltrlflsdipslvelpssiqnlhklehleiencinletlptginlesLESLDLSGCSRLRTFPDISTNISDL 851

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   821 YFNDIEMQEIPLWVKKISRLQTLILNGCKKLVSLPQLPDSLSYLKVV---NCESLERLD---------------CSFHNP 882
Cdd:PLN03210  852 NLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKLKHLETVdfsDCGALTEASwngspsevamatdniHSKLPS 931

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   883 KMSLGFINCLKLNKEAKeLIIQITTKCTVLPGREVPVYFTHRTKNGSSLRVNL-NRRPLSTASRFKACILLVNKyckene 961
Cdd:PLN03210  932 TVCINFINCFNLDQEAL-LQQQSIFKQLILSGEEVPSYFTHRTTGASLTNIPLlHISPCQPFFRFRACAVVDSE------ 1004

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   962 vkevfgrkmmkaSYCIIDLGLDVQ--CRPT----HHFLPP---------SLTEHLYIFD----FEADVTS----NELFCD 1018
Cdd:PLN03210 1005 ------------SFFIISVSFDIQvcCRFIdrlgNHFDSPyqphvfsvtKKGSHLVIFDccfpLNEDNAPlaelNYDHVD 1072

                        1130
                  ....*....|....*....
gi 22330441  1019 FQV----DSNEMVIKECGI 1033
Cdd:PLN03210 1073 IQFrltnKNSQLKLKGCGI 1091
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 33-196 1.19e-63

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 212.61  E-value: 1.19e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441     33 HQVFPSFRGEDVRRGFLSHIHKEFQRKGITPFID-NEIKRGESIGLEIIHAIRESKIAIVLLSRNYASSSWCLDELVEIM 111
Cdd:pfam01582    1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDdRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    112 KCKEEFSQIVIPIFYRVDPSDVKKLTGNFGNVFKNNCVGKTNEVIRKWRQALAKMGTTtgYDSRNWDNEATMIENIATDI 191
Cdd:pfam01582   81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIAYDI 158


                   ....*
gi 22330441    192 SNMLN 196
Cdd:pfam01582  159 SNKLN 163
TIR smart00255
Toll - interleukin 1 - resistance;
32-168 1.84e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 148.63  E-value: 1.84e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441      32 THQVFPSFRG-EDVRRGFLSHIHKEFQRKGITPFIDNEIkRGESIGLEIIHAIRESKIAIVLLSRNYASSSWCLDELVEI 110
Cdd:smart00255    1 EYDVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFE-PGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441     111 MKCKEEF-SQIVIPIFYRVDPSDVKKLTGNFGNVFKNNCVGKTNEVI-RKWRQALAKMGT 168
Cdd:smart00255   80 LENALEEgGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKeQFWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-805 1.65e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 1.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  582 PNLKFLRFYYRYGDESDKLYLPQGLNYLSQKLKILEWDHFPLTCMPSNFCTEYLVELNMRFSKLHKLWEGNRPLANLNWM 661
Cdd:COG4886   62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  662 YLNHSKIlKELPD-LSTATNLQELFLVKCsSLVELPSSIGKATNLQKLYLNmCTSLVELPSSIGNLHKLQKLTLNGCsKL 740
Cdd:COG4886  142 DLSNNQL-TDLPEpLGNLTNLKSLDLSNN-QLTDLPEELGNLTNLKELDLS-NNQITDLPEPLGNLTNLEELDLSGN-QL 217

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22330441  741 EVLPANI-NLESLDELDLTDCLvLKRFPEIS--TNIKVLKLLRTTIKEVPSSIKsWPRLRDLELSYNQ 805
Cdd:COG4886  218 TDLPEPLaNLTNLETLDLSNNQ-LTDLPELGnlTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
643-878 3.70e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  643 SKLHKLWEGNRPLANLNWMYLNHSKILKELPDLstaTNLQELFLVKCSSLVELpssigkaTNLQKLYLNmCTSLVELPSS 722
Cdd:COG4886   63 SSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL---TNLTELDLSGNEELSNL-------TNLESLDLS-GNQLTDLPEE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  723 IGNLHKLQKLTLNGCsKLEVLPANI-NLESLDELDLTDCLvlkrfpeistnikvlkllrttIKEVPSSIKSWPRLRDLEL 801
Cdd:COG4886  132 LANLTNLKELDLSNN-QLTDLPEPLgNLTNLKSLDLSNNQ---------------------LTDLPEELGNLTNLKELDL 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22330441  802 SYNQ--NLKGFMHALDIITTMYFNDIEMQEIPLWVKKISRLQTLILNGCkKLVSLPQLPdslsylkvvNCESLERLDCS 878
Cdd:COG4886  190 SNNQitDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN-QLTDLPELG---------NLTNLEELDLS 258
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 35-134 1.24e-15

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 73.89  E-value: 1.24e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441     35 VFPSFRGEDvrRGFLSHIHKEFQRKGITPFID-NEIKRGESIGLEIIHAIRESKIAIVLLSRNYASSSWCLDELvEIMKC 113
Cdd:pfam13676    1 VFISYAGED--RAWAEWLADALEAAGYRVWLDrWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEW-EAALA 77

                           90       100
                   ....*....|....*....|.
gi 22330441    114 KEEFSQIVIPIfyRVDPSDVK 134
Cdd:pfam13676   78 DPEGRKRLIPV--RLECDLEL 96
PLN03194 PLN03194
putative disease resistance protein; Provisional
 21-190 2.69e-15

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 75.24  E-value: 2.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    21 PFPSSSSSHKwTHQVFPSFRGEDVRRGFLSHIHKEFQRKGITPFIDNE-IKRGESIGLEIIHAIRESKIAIVLLSRNYAS 99
Cdd:PLN03194   16 HYPSSSSSAK-PCDVFINHRGIDTKRTIATLLYDHLSRLNLRPFLDNKnMKPGDKLFDKINSAIRNCKVGVAVFSPRYCE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   100 SSWCLDELVEIMKCKEEfsqiVIPIFYRVDPSDVKkltgnfgnvFKNNCVGKTNEvIRKWRQALAKMGTTTG--YDS--R 175
Cdd:PLN03194   95 SYFCLHELALIMESKKR----VIPIFCDVKPSQLR---------VVDNGTCPDEE-IRRFNWALEEAKYTVGltFDSlkG 160

                         170
                  ....*....|....*
gi 22330441   176 NWDNEATMIENIATD 190
Cdd:PLN03194  161 NWSEVVTMASDAVIK 175
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
638-878 2.50e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  638 LNMRFSKLHKLWEGNRPLANLNWMYLNHSKILKELPDLSTATNLQELFLVKCSSLVELPSSIGKATNLQKLYLNMCTSLV 717
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  718 EL-PSSIGNLHKLQKLTLNGCSKLEVLPaniNLESldeLDLTDCLVLKRFPEIS--TNIKVLKLLRTTIKEVPSSIKSWP 794
Cdd:COG4886   86 LLgLTDLGDLTNLTELDLSGNEELSNLT---NLES---LDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  795 RLRDLELSYNQ--NLKGFMHALDIITTMYFNDIEMQEIPLWVKKISRLQTLILNGCKklvsLPQLPDSLSylkvvNCESL 872
Cdd:COG4886  160 NLKSLDLSNNQltDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ----LTDLPEPLA-----NLTNL 230


                 ....*.
gi 22330441  873 ERLDCS 878
Cdd:COG4886  231 ETLDLS 236
NB-ARC pfam00931
NB-ARC domain;
223-450 1.14e-10

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 63.17  E-value: 1.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    223 LHSDEVRMIGIWGPSGIGKTTIARILFSQF---------------SDSFELSVFMENVKELMYTRPVcsdeysaklhlqk 287
Cdd:pfam00931   13 SEKDEPGIVGIHGMGGVGKTTLAAQIFNDFdeveghfdsvawvvvSKTFTISTLQQTILQNLGLSED------------- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    288 qfmsqiinhkDIEIPHLGVVEDR----LKDKKVFIVLDNIDQSIQLDAIAKESRWFGHGSRIIITTQDRKLLKAHDGINH 363
Cdd:pfam00931   80 ----------DWDNKEEGELARKirraLLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGGPSD 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    364 IYNVNFPSAYEACQIFCMYAFGQKF-PKDGFEELAWEVAKLLGGLPLGLRVMGSHFRgmSKH---EWINALPRLRTRLDA 439
Cdd:pfam00931  150 PHEVELLEPDEAWELFENKVFPKTLgECELLEDVAKEIVEKCRGLPLALKVLGGLLS--CKKtveEWKHVYDVLQSELKS 227

                          250
                   ....*....|....*..
gi 22330441    440 N------IQSILKFSYN 450
Cdd:pfam00931  228 NsyslnsVRSILQLSYE 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
602-843 1.18e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  602 LPQGLNYLSqKLKILEWDHFPLTCMPSNF--CTEyLVELNMRFSKLHKLWEGNRPLANLNWMYLNHSKIlKELPD-LSTA 678
Cdd:COG4886  128 LPEELANLT-NLKELDLSNNQLTDLPEPLgnLTN-LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI-TDLPEpLGNL 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  679 TNLQELFLVKCSsLVELPSSIGKATNLQKLYLNMC-----------TSLVEL---------PSSIGNLHKLQKLTLNGCS 738
Cdd:COG4886  205 TNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNqltdlpelgnlTNLEELdlsnnqltdLPPLANLTNLKTLDLSNNQ 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  739 ----KLEVLPANINLESLDEL--DLTDCLVLKRFPEISTNIKVLKLLRTTIKEVPSSIKSWPRLRDLELSYNQNLKGFMH 812
Cdd:COG4886  284 ltdlKLKELELLLGLNSLLLLllLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        250       260       270
                 ....*....|....*....|....*....|.
gi 22330441  813 ALDIITTMYFNDIEMQEIPLWVKKISRLQTL 843
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 634-652 9.35e-06

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 43.10  E-value: 9.35e-06
                           10
                   ....*....|....*....
gi 22330441    634 YLVELNMRFSKLHKLWEGN 652
Cdd:pfam07725    1 NLVELNMPYSKLEKLWEGV 19
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
233-325 1.54e-05

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 48.31  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  233 IWGPSGIGKTTIARILFSQFSDSFElsvfmenvKELMYTRPV---CSDEYSaklhlQKQFMSQIINH--KDIEIPHLGV- 306
Cdd:COG1474   56 IYGPTGTGKTAVAKYVLEELEEEAE--------ERGVDVRVVyvnCRQAST-----RYRVLSRILEElgSGEDIPSTGLs 122

                         90       100
                 ....*....|....*....|....*...
gi 22330441  307 ---VEDRL------KDKKVFIVLDNIDQ 325
Cdd:COG1474  123 tdeLFDRLyealdeRDGVLVVVLDEIDY 150
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 657-805 1.73e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   657 NLNWMYLNHSKILKELP-DLSTATNLQELFLVKCSSLVELPSSIGKATNLQKLYL--NMCTSlvELPSSIGNLHKLQklt 733
Cdd:PLN00113  213 SLKWIYLGYNNLSGEIPyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLyqNKLSG--PIPPSIFSLQKLI--- 287

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22330441   734 lngcsklevlpaninlesldELDLTDCLVLKRFPEISTNIKVLKLLR----TTIKEVPSSIKSWPRLRDLELSYNQ 805
Cdd:PLN00113  288 --------------------SLDLSDNSLSGEIPELVIQLQNLEILHlfsnNFTGKIPVALTSLPRLQVLQLWSNK 343
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 223-268 3.14e-05

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 47.39  E-value: 3.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 22330441   223 LHSdevrMIgIWGPSGIGKTTIARILFSQFSDSFE-LSVFMENVKEL 268
Cdd:PRK13342   36 LSS----MI-LWGPPGTGKTTLARIIAGATDAPFEaLSAVTSGVKDL 77
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 223-268 4.39e-05

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 47.36  E-value: 4.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 22330441  223 LHSdevrMIgIWGPSGIGKTTIARILFSQFSDSFE-LSVFMENVKEL 268
Cdd:COG2256   49 LSS----MI-LWGPPGTGKTTLARLIANATDAEFVaLSAVTSGVKDI 90
GMPK cd00071
Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), ...
 230-260 1.24e-04

Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP). This enzyme is also important for the activation of some antiviral and anticancer agents, such as acyclovir, ganciclovir, carbovir, and thiopurines.


Pssm-ID: 238026  Cd Length: 137  Bit Score: 42.90  E-value: 1.24e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 22330441  230 MIGIWGPSGIGKTTIARILFSQFSDSFELSV 260
Cdd:cd00071    1 LIVLSGPSGVGKSTLLKRLLEEFDPNFGFSV 31
PRK15386 PRK15386
type III secretion effector GogB;
694-897 1.85e-04

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 45.25  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   694 ELPSSIGKATNLQKLYLNMC--TSLVELPssignlHKLQKLTLNGCSKLEVLPANINlESLDELDLTDCLVLKRFPEIST 771
Cdd:PRK15386   43 EITPQIEEARASGRLYIKDCdiESLPVLP------NELTEITIENCNNLTTLPGSIP-EGLEKLTVCHCPEISGLPESVR 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441   772 NIKVLKLLRTTIKEVPSSIKSwprlrdleLSYNqnlkgfmhaldIITTMYFNDIEMQEIPlwvkkisRLQTLILNGCKKL 851
Cdd:PRK15386  116 SLEIKGSATDSIKNVPNGLTS--------LSIN-----------SYNPENQARIDNLISP-------SLKTLSLTGCSNI 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 22330441   852 VSLPQLPDSLSYLKvVNCESLERLDCSFHN-PK-MSLGFINCLKLNKE 897
Cdd:PRK15386  170 ILPEKLPESLQSIT-LHIEQKTTWNISFEGfPDgLDIDLQNSVLLSPD 216
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 912-1007 4.01e-04

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 40.89  E-value: 4.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441    912 LPGREVPVYFTHRtKNGSSLRVNLNRRPLSTAS-RFKACILLVNKYCKENEVKEVFGRKMMKAS--------------YC 976
Cdd:pfam20160    1 LPGSQIPEWFNHQ-STGSSISIKLPENWYNDNFlGFAVCAVGSLIPSLHNFLGYIHFFLIPLVSlwdtskangktpndYG 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 22330441    977 IIDLGldVQCRPTHHFLPPSLTEHLYIFDFE 1007
Cdd:pfam20160   80 RIEAS--FEFPSDLHEIKQCGVRLIYKDEVE 108
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
686-878 2.49e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  686 LVKCSSLVELPSSIGKATNLQKLYLNMCTSLVELPSSIGNLHKLQKLTLNGCSKLEVLPANINL---ESLDELDLTDCLV 762
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLlllLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  763 LKRFPEISTNIKVLKLLRTTIKEVPSSIKSWPRLRDLELSYNQ--NLKGFMHALDIITTMYFNDIEMQEIPLWVKKISRL 840
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQltDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 22330441  841 QTLILNGCKklvsLPQLPDSLSYLKvvnceSLERLDCS 878
Cdd:COG4886  162 KSLDLSNNQ----LTDLPEELGNLT-----NLKELDLS 190
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 233-277 3.14e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 37.97  E-value: 3.14e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 22330441    233 IWGPSGIGKTTIARILFSQFSDSFELSvfmenvKELMYTRPVCSD 277
Cdd:pfam00910    3 LYGPPGCGKSTLAKYLARALLKKLGLP------KDSVYSRNPDDD 41
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 224-254 7.30e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 39.05  E-value: 7.30e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 22330441  224 HSDEVRMIGIWGPSGIGKTTIARILFSQFSD 254
Cdd:COG0572    3 RSGKPRIIGIAGPSGSGKTTFARRLAEQLGA 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 662-804 7.46e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 7.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  662 YLNHSKIlKELPDLSTATNLQELFLV--KCSSLVELPSsigkATNLQKLYL--NMCTSLVELpssiGNLHKLQKLTLNG- 736
Cdd:cd21340    8 YLNDKNI-TKIDNLSLCKNLKVLYLYdnKITKIENLEF----LTNLTHLYLqnNQIEKIENL----ENLVNLKKLYLGGn 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22330441  737 ----------CSKLEVL----------------PANIN--LESLDELDLTDClvlkRFPEIStNIKVLKLLRT------- 781
Cdd:cd21340   79 risvveglenLTNLEELhienqrlppgekltfdPRSLAalSNSLRVLNISGN----NIDSLE-PLAPLRNLEQldasnnq 153

                        170       180
                 ....*....|....*....|....*
gi 22330441  782 --TIKEVPSSIKSWPRLRDLELSYN 804
Cdd:cd21340  154 isDLEELLDLLSSWPSLRELDLTGN 178
Gmk COG0194
Guanylate kinase [Nucleotide transport and metabolism];
235-260 9.26e-03

Guanylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 439964  Cd Length: 190  Bit Score: 38.51  E-value: 9.26e-03
                         10        20
                 ....*....|....*....|....*.
gi 22330441  235 GPSGIGKTTIARILFSQFSDsFELSV 260
Cdd:COG0194    9 GPSGAGKTTLVKALLERDPD-LRFSV 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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