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Conserved domains on  [gi|15223075|ref|NP_177178|]
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CYCLIN D1;1 [Arabidopsis thaliana]

Protein Classification

cyclin-D( domain architecture ID 15334368)

cyclin-D such the G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 81-179 2.00e-55

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410246  Cd Length: 99  Bit Score: 175.97  E-value: 2.00e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  81 AREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSGWPMQLLAVACLSLAAKMEEILVPSLFDFQVAGVKYL 160
Cdd:cd20543   1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                        90
                ....*....|....*....
gi 15223075 161 FEAKTIKRMELLVLSVLDW 179
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 184-276 1.29e-24

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410247  Cd Length: 90  Bit Score: 95.46  E-value: 1.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075 184 VTPFDFISFFAYKIDPSGTfLGFFISHATEIILSNIKEASFLEYWPSSIAAAAILCVANELPSLSSvvNPHESPETWCDG 263
Cdd:cd20544   1 VTPFSFLDYFISKIGLSDS-REELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDA--DDASSRLSLLLS 77

                        90
                ....*....|...
gi 15223075 264 LSKEKIVRCYRLM 276
Cdd:cd20544  78 PNKEKVKKCYELM 90
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 81-179 2.00e-55

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 175.97  E-value: 2.00e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  81 AREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSGWPMQLLAVACLSLAAKMEEILVPSLFDFQVAGVKYL 160
Cdd:cd20543   1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                        90
                ....*....|....*....
gi 15223075 161 FEAKTIKRMELLVLSVLDW 179
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 50-182 2.02e-38

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 133.03  E-value: 2.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075    50 DSIACFIEDERHFVPGHDYLSrfQTRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETsgwPMQL 129
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMD--QQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKN---KLQL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 15223075   130 LAVACLSLAAKMEEILVPSLFDFQVAGVKyLFEAKTIKRMELLVLSVLDWRLR 182
Cdd:pfam00134  76 VGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYTREEILRMERLILETLNFDLS 127
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 184-276 1.29e-24

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 95.46  E-value: 1.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075 184 VTPFDFISFFAYKIDPSGTfLGFFISHATEIILSNIKEASFLEYWPSSIAAAAILCVANELPSLSSvvNPHESPETWCDG 263
Cdd:cd20544   1 VTPFSFLDYFISKIGLSDS-REELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDA--DDASSRLSLLLS 77

                        90
                ....*....|...
gi 15223075 264 LSKEKIVRCYRLM 276
Cdd:cd20544  78 PNKEKVKKCYELM 90
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 88-175 2.93e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 75.32  E-value: 2.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075     88 WILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPEtsgWPMQLLAVACLSLAAKMEEILVPSLFDFQVAGVkylFEAKTIK 167
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLK---YSPSLIAAAALYLASKTEETPPWTKELVHYTGY---FTEEEIL 75


                   ....*...
gi 15223075    168 RMELLVLS 175
Cdd:smart00385  76 RMERLLLE 83
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
59-234 1.30e-15

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 77.12  E-value: 1.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  59 ERHFVPGHDYLSRFQTrsLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLA 138
Cdd:COG5024 192 ELIDLPNPNYLIKQSL--YEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK---YQLVGISALFIA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075 139 AKMEEILVPSLFDFQVAgVKYLFEAKTIKRMELLVLSVLDWRLRSVTPFDFISFFAyKIDPSGTFLGFFISHATEIILSN 218
Cdd:COG5024 267 SKYEEVNCPSIKDLVYA-TDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRIS-KASDYDIFSRTPAKFSSEISPVD 344

                       170
                ....*....|....*.
gi 15223075 219 IKEASFLEYWPSSIAA 234
Cdd:COG5024 345 YKFIQISPSWCAAAAM 360
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 184-308 3.35e-10

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 56.86  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075   184 VTPFDFISFFAyKIDPSgTFLGFFISHATEIILSNIKEASFLEYWPSSIAAAAILCVANELpslssvvnpheSPETWCD- 262
Cdd:pfam02984   1 PTPLSFLRRFS-KAADY-LHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL-----------NSPEWTEt 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15223075   263 -----GLSKEKIVRCYRLMKAMAIENNRLNTPKVIAKLRVSVR-ASSTLTRP 308
Cdd:pfam02984  68 lehytGYSEEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFmKVSTLPPL 119
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 81-179 2.00e-55

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 175.97  E-value: 2.00e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  81 AREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSGWPMQLLAVACLSLAAKMEEILVPSLFDFQVAGVKYL 160
Cdd:cd20543   1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                        90
                ....*....|....*....
gi 15223075 161 FEAKTIKRMELLVLSVLDW 179
Cdd:cd20543  81 FEAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 50-182 2.02e-38

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 133.03  E-value: 2.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075    50 DSIACFIEDERHFVPGHDYLSrfQTRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETsgwPMQL 129
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMD--QQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKN---KLQL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 15223075   130 LAVACLSLAAKMEEILVPSLFDFQVAGVKyLFEAKTIKRMELLVLSVLDWRLR 182
Cdd:pfam00134  76 VGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYTREEILRMERLILETLNFDLS 127
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 184-276 1.29e-24

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 95.46  E-value: 1.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075 184 VTPFDFISFFAYKIDPSGTfLGFFISHATEIILSNIKEASFLEYWPSSIAAAAILCVANELPSLSSvvNPHESPETWCDG 263
Cdd:cd20544   1 VTPFSFLDYFISKIGLSDS-REELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDA--DDASSRLSLLLS 77

                        90
                ....*....|...
gi 15223075 264 LSKEKIVRCYRLM 276
Cdd:cd20544  78 PNKEKVKKCYELM 90
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 57-179 1.40e-17

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 78.11  E-value: 1.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  57 EDERHFVPGHDYLSRFQtrSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLS 136
Cdd:cd20568  18 ELELKTLPNPNYMDDQK--ELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNK---LQLVGISALF 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15223075 137 LAAKMEEILVPSLFDFqVAGVKYLFEAKTIKRMELLVLSVLDW 179
Cdd:cd20568  93 IASKYEEVNSPSIKNF-AYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 88-175 2.93e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 75.32  E-value: 2.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075     88 WILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPEtsgWPMQLLAVACLSLAAKMEEILVPSLFDFQVAGVkylFEAKTIK 167
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLK---YSPSLIAAAALYLASKTEETPPWTKELVHYTGY---FTEEEIL 75


                   ....*...
gi 15223075    168 RMELLVLS 175
Cdd:smart00385  76 RMERLLLE 83
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 50-178 1.15e-16

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 75.26  E-value: 1.15e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  50 DSIACFIEDERHFVPGHDYLSRFQtrSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQL 129
Cdd:cd20507   7 DIYKYLRQLEKKYAIDPDYLSGQP--EITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKK---LQL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15223075 130 LAVACLSLAAKMEEILVPSLFDFqVAGVKYLFEAKTIKRMELLVLSVLD 178
Cdd:cd20507  82 VGVTALLIASKYEEIYPPEIKDF-VYITDNAYTREEILQMERDILKTLD 129
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
59-234 1.30e-15

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 77.12  E-value: 1.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  59 ERHFVPGHDYLSRFQTrsLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLA 138
Cdd:COG5024 192 ELIDLPNPNYLIKQSL--YEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK---YQLVGISALFIA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075 139 AKMEEILVPSLFDFQVAgVKYLFEAKTIKRMELLVLSVLDWRLRSVTPFDFISFFAyKIDPSGTFLGFFISHATEIILSN 218
Cdd:COG5024 267 SKYEEVNCPSIKDLVYA-TDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRIS-KASDYDIFSRTPAKFSSEISPVD 344

                       170
                ....*....|....*.
gi 15223075 219 IKEASFLEYWPSSIAA 234
Cdd:COG5024 345 YKFIQISPSWCAAAAM 360
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 82-181 5.79e-15

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 69.66  E-value: 5.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  82 REDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKMEEILVPslfdfQVAGVKYL- 160
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSL---LQLLGITCLFIACKFEERFPP-----EVATLCYLt 72

                        90       100
                ....*....|....*....|....
gi 15223075 161 ---FEAKTIKRMELLVLSVLDWRL 181
Cdd:cd20542  73 ddsYSKKQVLRMERRVLRRLRFDL 96
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 57-178 8.15e-15

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 69.97  E-value: 8.15e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  57 EDERHFVPGHDYLsRFQtRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLS 136
Cdd:cd20504  12 ESELKHRPKPDYM-RKQ-PDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSK---LQLVGTACMF 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15223075 137 LAAKMEEILVPSLFDFQvagvkYL----FEAKTIKRMELLVLSVLD 178
Cdd:cd20504  87 IAAKYEEIYPPEVEEFV-----YItddtYTKKQVLRMEHLVLKVLS 127
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 64-152 4.05e-14

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 68.59  E-value: 4.05e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  64 PGHDYLSRFQtRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKMEE 143
Cdd:cd20562  25 PLPDYMEKIQ-RDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQR---LQLLGVSCMLIASKYEE 100


                ....*....
gi 15223075 144 ILVPSLFDF 152
Cdd:cd20562 101 ICAPQVEEF 109
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 56-179 1.94e-13

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 66.57  E-value: 1.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  56 IEDERHFVPGHDYLSRFQtrSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARR-LPETSgwpMQLLAVAC 134
Cdd:cd20519  13 LKKEELYKRDRDFLNRHP--SLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTnVPKTQ---LQLIGITC 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15223075 135 LSLAAKMEEILVPSLFDFqvagvKYL----FEAKTIKRMELLVLSVLDW 179
Cdd:cd20519  88 LFIAAKLEEIYPPKLSEF-----AYVtdgaCTEDEILTMELIILKALNW 131
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 80-179 2.26e-12

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 63.54  E-value: 2.26e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  80 SAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKMEEILVPSLFDFqVAGVKY 159
Cdd:cd20561  35 SMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGK---LQLVGTAAMLLASKFEEIYPPEVAEF-VYITDD 110

                        90       100
                ....*....|....*....|
gi 15223075 160 LFEAKTIKRMELLVLSVLDW 179
Cdd:cd20561 111 TYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 82-179 3.72e-12

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 61.85  E-value: 3.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  82 REDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKMEEI--LVPSLFDFQVAGVKY 159
Cdd:cd20528   7 RRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQ---LHLVALTCLLLAAKFEELddNIPKISDLNRYLCNS 83

                        90       100
                ....*....|....*....|
gi 15223075 160 LFEAKTIKRMELLVLSVLDW 179
Cdd:cd20528  84 VYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 86-177 3.75e-12

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 61.57  E-value: 3.75e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  86 VAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKMEEILVPSLFDFqVAGVKYLFEAKT 165
Cdd:cd20536   6 ISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDC---FQLLGVTSLLIACKQEEIYPPEVKDL-LALCCGAYTREQ 81

                        90
                ....*....|..
gi 15223075 166 IKRMELLVLSVL 177
Cdd:cd20536  82 ICNLECIILTKL 93
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 184-308 3.35e-10

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 56.86  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075   184 VTPFDFISFFAyKIDPSgTFLGFFISHATEIILSNIKEASFLEYWPSSIAAAAILCVANELpslssvvnpheSPETWCD- 262
Cdd:pfam02984   1 PTPLSFLRRFS-KAADY-LHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL-----------NSPEWTEt 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15223075   263 -----GLSKEKIVRCYRLMKAMAIENNRLNTPKVIAKLRVSVR-ASSTLTRP 308
Cdd:pfam02984  68 lehytGYSEEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFmKVSTLPPL 119
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 86-177 4.55e-09

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 54.85  E-value: 4.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  86 VAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKMEEILVPSLFDFqVAGVKYLFEAKT 165
Cdd:cd20560  73 VDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGK---LQLVGTAAILLASKYEEIYPPEVDEF-VYITDDTYTKKQ 148

                        90
                ....*....|..
gi 15223075 166 IKRMELLVLSVL 177
Cdd:cd20560 149 LLRMEHLLLKVL 160
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 73-179 6.22e-09

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 53.71  E-value: 6.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  73 QTRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKMEEILVPSLFDF 152
Cdd:cd20566  31 DGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKK---LQLVGVTALLLASKYEEMYSPEIGDF 107

                        90       100
                ....*....|....*....|....*..
gi 15223075 153 qVAGVKYLFEAKTIKRMELLVLSVLDW 179
Cdd:cd20566 108 -VYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 59-179 7.32e-09

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 53.89  E-value: 7.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  59 ERHFVPGHDYLSrfQTRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLA 138
Cdd:cd20567  33 EPESCVPPYYMS--QQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKE---LQLVGVTAMLIA 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15223075 139 AKMEEILVPSLFDFQVAGVKyLFEAKTIKRMELLVLSVLDW 179
Cdd:cd20567 108 SKYEEIWAPEVNDFVYISDN-AYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 82-181 1.07e-08

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 51.93  E-value: 1.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  82 REDSVAWILKVQAYYNFQPLTAYLAVNYMDRFL---YARrlPETsgwpMQLLAVACLSLAAKM--EEILVPSLFDF-QVA 155
Cdd:cd20526   2 RDEAVRWLAELNSQFKFYPETFALAVSILDRFLasvKAR--PKY----LRCIAISCLFLAAKTneEDEVIPSTKDLvRVS 75

                        90       100
                ....*....|....*....|....*.
gi 15223075 156 GVKylFEAKTIKRMELLVLSVLDWRL 181
Cdd:cd20526  76 KCG--CSVAEVLRMERIILDKLHWDL 99
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 56-179 1.36e-08

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 52.57  E-value: 1.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  56 IEDERHFVPGHdylsrFQTRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACL 135
Cdd:cd20565  15 LEEEQAVRPKY-----LEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKM---LQLVGVTAM 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15223075 136 SLAAKMEEILVPSLFDFQVAgVKYLFEAKTIKRMELLVLSVLDW 179
Cdd:cd20565  87 FIASKYEEMYPPEIGDFAFV-TDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 88-179 1.60e-08

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 52.57  E-value: 1.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  88 WILKVQAYYNFQPLTAYLAVNYMDRFLYARR-LPETSgwpMQLLAVACLSLAAKMEEILVPSLFDFQVAGVKYLFEAKtI 166
Cdd:cd20579  49 WLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVVKTR---LQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDE-I 124

                        90
                ....*....|...
gi 15223075 167 KRMELLVLSVLDW 179
Cdd:cd20579 125 LSMELIIMKALKW 137
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 59-179 2.29e-08

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 52.30  E-value: 2.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  59 ERHFVPGHDYLSRFQtRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLA 138
Cdd:cd20515  34 EERYLPSASYFKCVQ-TEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQ---LQLLGAVCLFLA 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15223075 139 AKMEEIlVPSLFDFQVAGVKYLFEAKTIKRMELLVLSVLDW 179
Cdd:cd20515 110 SKLKET-IPLTAEKLCIYTDNSITLQELLDWELLVLTKLKW 149
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 76-179 3.12e-08

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 51.77  E-value: 3.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  76 SLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwPMQLLAVACLSLAAKMEEILVPSLFDFQVA 155
Cdd:cd20580  37 ALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKNINKS--MLQLIGITSLFIASKLEEIYPPKLHEFAYV 114

                        90       100
                ....*....|....*....|....
gi 15223075 156 GVKYLFEaKTIKRMELLVLSVLDW 179
Cdd:cd20580 115 TDGACSE-DDILDMELIILKALKW 137
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 86-172 6.99e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 49.33  E-value: 6.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  86 VAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLpetSGWPMQLLAVACLSLAAKMEEIlVPSLFDF-QVAGVKYlfeaK 164
Cdd:cd00043   3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLL---LGRSPELIAAACLYLACKLEEL-PRTLKEIaKVSGVSE----K 74


                ....*...
gi 15223075 165 TIKRMELL 172
Cdd:cd00043  75 ELRKAEKE 82
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 59-179 1.53e-06

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 47.28  E-value: 1.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  59 ERHFVPGHDYLSRFQTRSLdASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLA 138
Cdd:cd20573  33 EETCLPSVSYFKCVQKEIL-PSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSR---LQLLGATCMFLA 108

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15223075 139 AKMEEIlVPSLFDFQVAGVKYLFEAKTIKRMELLVLSVLDW 179
Cdd:cd20573 109 SKMKET-IPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 57-178 6.50e-05

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 42.24  E-value: 6.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  57 EDERHFVPgHDYLSRfQTrSLDASAREDSVAWILKVQAyyNFQpL---TAYLAVNYMDRFLYARRLPETSgwpMQLLAVA 133
Cdd:cd20508  26 EREEKFVV-PDYLEK-QT-ELTPSMRAILVDWLVEVQE--NFE-LnheTLYLAVKLVDLYLSKKVVKKEK---LQLLGAT 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15223075 134 CLSLAAKMEEILVPSLFDFQvagvkYL----FEAKTIKRMELLVLSVLD 178
Cdd:cd20508  97 AILIASKFDERCPPCVDDFL-----YIcddaYTREELLKMEREILKTLD 140
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 86-143 2.23e-04

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 39.61  E-value: 2.23e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15223075  86 VAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKMEE 143
Cdd:cd20521   8 VDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSK---LQLLGIACMVIATRFLG 62
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 59-179 3.78e-04

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 40.36  E-value: 3.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  59 ERHFVPGHDYLSRFQtRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYArrLPeTSGWPMQLLAVACLSLA 138
Cdd:cd20575  34 EERYVPRVSYFQCVQ-REIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSC--VP-TRKAQLQLLGAVCMLLA 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15223075 139 AKMEEIlVPSLFDFQVAGVKYLFEAKTIKRMELLVLSVLDW 179
Cdd:cd20575 110 SKLRET-TPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKW 149
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 59-179 3.96e-04

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 40.36  E-value: 3.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  59 ERHFVPGHDYLSRFQtRSLDASAREDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYArrLPeTSGWPMQLLAVACLSLA 138
Cdd:cd20574  34 EERYLPQCSYFKCVQ-KDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAV--VP-TRKCHLQLLGAVCMFLA 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15223075 139 AKMEEIlVPSLFDFQVAGVKYLFEAKTIKRMELLVLSVLDW 179
Cdd:cd20574 110 SKLKET-IPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 89-180 1.16e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 37.75  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  89 ILKVQAYYNFQPLTAYLAVNYMDRFLYARrlpETSGWPMQLLAVACLSLAAKMEE--ILVPSLFDFQVA-GVKYlfEAKT 165
Cdd:cd20559   6 LFELHVELRLSPQTFFLSVNLIDRYCSKR---IVLKKHYQLVGCTCLWIASKFWEskARVPLLSELSKMcCNSY--GEEL 80

                        90
                ....*....|....*
gi 15223075 166 IKRMELLVLSVLDWR 180
Cdd:cd20559  81 FIQMEMHILNTLNWD 95
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 82-180 3.00e-03

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 36.72  E-value: 3.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  82 REDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPetsgwPMQLLAV--ACLSLAAKM--EEILVPSLFDFqVAGV 157
Cdd:cd20583   2 RDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQ-----PKHLGCVglSCFYLAVKAieEERNVPLATDL-IRIS 75

                        90       100
                ....*....|....*....|...
gi 15223075 158 KYLFEAKTIKRMELLVLSVLDWR 180
Cdd:cd20583  76 QYRFTVSDMMRMEKIILEKLCWK 98
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 100-179 5.12e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 35.71  E-value: 5.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075 100 PLTAYLAVNYMDRFL-YARRLPETSGWPMQLLAVACLSLAAKMEEILVPSLFDF-QVAGvkylFEAKTIKRMELLVLSVL 177
Cdd:cd20557  17 PSVVLLALVYLERLRrRLPEALLGQEGSPYRLFLVALMLASKYLDDESYSNKSWaEISG----LPVRELNAMEREFLEAL 92


                ..
gi 15223075 178 DW 179
Cdd:cd20557  93 DW 94
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 82-177 5.24e-03

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 35.79  E-value: 5.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223075  82 REDSVAWILKVQAYYNFQPLTAYLAVNYMDRFLYARRLPETSgwpMQLLAVACLSLAAKM--EEILVPSLFDFqVAGVKY 159
Cdd:cd20523   1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKH---LACITVSCFHIAIKSveEDQNIPSAEDL-IRISQC 76

                        90
                ....*....|....*...
gi 15223075 160 LFEAKTIKRMELLVLSVL 177
Cdd:cd20523  77 GCTAADLMRMEGIILEKL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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