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Conserved domains on  [gi|15220154|ref|NP_178167|]
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Sterile alpha motif (SAM) domain-containing protein [Arabidopsis thaliana]

Protein Classification

SAM domain-containing protein( domain architecture ID 10175456)

SAM (sterile alpha motif) domain-containing protein may interact with proteins, RNAs and membrane lipids, and may play a role in protein homo- and/or hetero- dimerization/oligomerization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 2-62 1.86e-06

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


:

Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 43.38  E-value: 1.86e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15220154   2 DWFSWLSRTNLEasliyEYGLSFSNNELEYEDIAYFNHEFLQSMGISIAKHRLEILKLARR 62
Cdd:cd09487   1 DVAEWLESLGLE-----QYADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQR 56
 
Name Accession Description Interval E-value
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 2-62 1.86e-06

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 43.38  E-value: 1.86e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15220154   2 DWFSWLSRTNLEasliyEYGLSFSNNELEYEDIAYFNHEFLQSMGISIAKHRLEILKLARR 62
Cdd:cd09487   1 DVAEWLESLGLE-----QYADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQR 56
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
5-58 1.73e-03

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 35.71  E-value: 1.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15220154     5 SWLSRTNLEasliyEYGLSFSNNELE-YEDIAYFNHEFLQSMGISIAKHRLEILK 58
Cdd:pfam07647  11 DWLRSIGLE-----QYTDNFRDQGITgAELLLRLTLEDLKRLGITSVGHRRKILK 60
 
Name Accession Description Interval E-value
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 2-62 1.86e-06

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 43.38  E-value: 1.86e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15220154   2 DWFSWLSRTNLEasliyEYGLSFSNNELEYEDIAYFNHEFLQSMGISIAKHRLEILKLARR 62
Cdd:cd09487   1 DVAEWLESLGLE-----QYADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQR 56
SAM_Ste50-like_fungal cd09533
SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or ...
 5-58 7.27e-05

SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or Ubc2 for Ustilago bypass of cyclase) subfamily is a putative protein-protein interaction domain. This group includes only fungal proteins. Basidiomycetes have an N-terminal SAM domain, central UBQ domain, and C-terminal SH3 domain, while Ascomycetes lack the SH3 domain. Ubc2 of Ustilago maydis is a major virulence and maize pathogenicity factor. It is required for filamentous growth (the budding haploid form of Ustilago maydis is a saprophyte, while filamentous dikaryotic form is a pathogen). Also the Ubc2 protein is involved in the pheromone-responsive morphogenesis via the MAP kinase cascade. The SAM domain is necessary for ubc2 function; deletion of SAM eliminates this function. A Lys-to-Glu mutation in the SAM domain of ubc2 gene induces temperature sensitivity.


Pssm-ID: 188932  Cd Length: 58  Bit Score: 39.22  E-value: 7.27e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15220154   5 SWLSRTNLEasliyEYGLSFSNNELEYEDIAYFNHEFLQSMGISIAKHRLEILK 58
Cdd:cd09533   4 DWLSSLGLP-----QYEDQFIENGITGDVLVALDHEDLKEMGITSVGHRLTILK 52
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
5-58 1.73e-03

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 35.71  E-value: 1.73e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15220154     5 SWLSRTNLEasliyEYGLSFSNNELE-YEDIAYFNHEFLQSMGISIAKHRLEILK 58
Cdd:pfam07647  11 DWLRSIGLE-----QYTDNFRDQGITgAELLLRLTLEDLKRLGITSVGHRRKILK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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