|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
207-737 |
1.90e-128 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 398.06 E-value: 1.90e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 207 SDFQPILKPYQLVGVNFLLLLYKKGIeGAILADEMGLGKTIQAITYLTLLsRLNNDPGPHLVVCPASVLENWERELRKWC 286
Cdd:COG0553 236 AGLKATLRPYQLEGAAWLLFLRRLGL-GGLLADDMGLGKTIQALALLLEL-KERGLARPVLIVAPTSLVGNWQRELAKFA 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 287 PSFTVLQYHGAARAAysRELNSLSKAgkpppfNVLLVCYSLFerhseqqKDDRKVLKRWRWSCVLMDEAHALKDKNSYRW 366
Cdd:COG0553 314 PGLRVLVLDGTRERA--KGANPFEDA------DLVITSYGLL-------RRDIELLAAVDWDLVILDEAQHIKNPATKRA 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 367 KNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENV---DLKKLLNAEDTELITRMKSILGPFILRRLKSD 443
Cdd:COG0553 379 KAVRAL--KARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAfreRFARPIEKGDEEALERLRRLLRPFLLRRTKED 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 444 VMQQLVPKIQRVEYVLMERKQEDAYKEAIEEYRAASQARlvKLSSKSLNSLAkALpkrqisnyfTQFRKIANHPLLirri 523
Cdd:COG0553 457 VLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGA--EGIRRRGLILA-AL---------TRLRQICSHPAL---- 520
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 524 ysdedviriarklhpigafgfecsldrVIEEVKGFNDfrihqllfqygvndtkgtlsdkhvmLSAKCRTLAELLPSMKKS 603
Cdd:COG0553 521 ---------------------------LLEEGAELSG-------------------------RSAKLEALLELLEELLAE 548
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 604 GHRVLIFSQWTSMLDILEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKSIFACLLSTRAGGQGLNLTGADTVIIHDM 683
Cdd:COG0553 549 GEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDL 628
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 15226870 684 DFNPQIDRQAEDRCHRIGQTKPVTIFRLVTKSTVDENIYEIAKRKLVLDAAVLE 737
Cdd:COG0553 629 WWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
213-739 |
9.52e-107 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 350.25 E-value: 9.52e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:PLN03142 170 MRDYQLAGLNWLIRLYENGING-ILADEMGLGKTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMNEIRRFCPVLRAV 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARA-AYSRElnSLSKAGKpppFNVLLVCYslferhsEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYrwknLMS 371
Cdd:PLN03142 249 KFHGNPEErAHQRE--ELLVAGK---FDVCVTSF-------EMAIKEKTALKRFSWRYIIIDEAHRIKNENSL----LSK 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 372 VAR--NANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTT-ENVDLKKLLNAED--TELITRMKSILGPFILRRLKSDVMQ 446
Cdd:PLN03142 313 TMRlfSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSaETFDEWFQISGENdqQEVVQQLHKVLRPFLLRRLKSDVEK 392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 447 QLVPKIQRVEYVLMERKQEDAYKEAIEeyraasqarlvklssKSLNSLAKALPKRQISNYFTQFRKIANHPllirriysd 526
Cdd:PLN03142 393 GLPPKKETILKVGMSQMQKQYYKALLQ---------------KDLDVVNAGGERKRLLNIAMQLRKCCNHP--------- 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 527 edviriarklhpigafgfecsldrvieevkgfndfrihqLLFQyGVNDTKGTLSDKH-VMLSAKCRTLAELLPSMKKSGH 605
Cdd:PLN03142 449 ---------------------------------------YLFQ-GAEPGPPYTTGEHlVENSGKMVLLDKLLPKLKERDS 488
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 606 RVLIFSQWTSMLDILEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKS-IFACLLSTRAGGQGLNLTGADTVIIHDMD 684
Cdd:PLN03142 489 RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSeKFVFLLSTRAGGLGINLATADIVILYDSD 568
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 15226870 685 FNPQIDRQAEDRCHRIGQTKPVTIFRLVTKSTVDENIYEIAKRKLVLDAAVLESG 739
Cdd:PLN03142 569 WNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQG 623
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
213-406 |
2.51e-78 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 249.41 E-value: 2.51e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIeGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGP-GGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARAAYSRElnslsKAGKPPPFNVLLVCYSLFERHSEQqkddrkvLKRWRWSCVLMDEAHALKDKNSYRWKNLMSV 372
Cdd:cd17919 80 VYHGSQRERAQIR-----AKEKLDKFDVVLTTYETLRRDKAS-------LRKFRWDLVVVDEAHRLKNPKSQLSKALKAL 147
|
170 180 190
....*....|....*....|....*....|....
gi 15226870 373 arNANQRLMLTGTPLQNDLHELWSLLEFMLPDIF 406
Cdd:cd17919 148 --RAKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
213-439 |
1.58e-67 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 222.23 E-value: 1.58e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNG-ILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARAAYsrelnsLSKAG--KPPPFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLM 370
Cdd:cd18003 80 TYYGSAKERK------LKRQGwmKPNSFHVCITSYQLVVQ-------DHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 371 SVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFtTENVDLKKLLN-----------AEDTELITRMKSILGPFILRR 439
Cdd:cd18003 147 NF--NTQRRLLLTGTPLQNSLMELWSLMHFLMPHIF-QSHQEFKEWFSnpltamsegsqEENEELVRRLHKVLRPFLLRR 223
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
213-406 |
5.01e-66 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 216.87 E-value: 5.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLsRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSG-ILADEMGLGKTIQVIAFLAYL-KEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARA-AYSRElNSLSKAGKpppFNVLLVCYSLferhSEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLMS 371
Cdd:cd17998 79 PYYGSQEErKHLRY-DILKGLED---FDVIVTTYNL----ATSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMT 150
|
170 180 190
....*....|....*....|....*....|....*
gi 15226870 372 VarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIF 406
Cdd:cd17998 151 I--NANFRLLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
216-520 |
9.33e-66 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 219.86 E-value: 9.33e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 216 YQLVGVNFLLLLYKKGIEGAILADEMGLGKTIQAITYLTLLSRLNNDPG-PHLVVCPASVLENWERELRKWC--PSFTVL 292
Cdd:pfam00176 1 YQIEGVNWMLSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARAAySRELNSLSKAGKpppFNVLLVCYSLFERHSEqqkddrkVLKRWRWSCVLMDEAHALKDKNSYrwKNLMSV 372
Cdd:pfam00176 81 VLHGNKRPQ-ERWKNDPNFLAD---FDVVITTYETLRKHKE-------LLKKVHWHRIVLDEGHRLKNSKSK--LSKALK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 373 ARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKK----LLNAEDTELITRMKSILGPFILRRLKSDVMQQL 448
Cdd:pfam00176 148 SLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWfdrpIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKSL 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15226870 449 VPKIQRVEYVLMERKQEDAYKEaieeyraasqarlvKLSSKSLNSLAKAL----PKRQISNYFTQFRKIANHPLLI 520
Cdd:pfam00176 228 PPKVEYILFCRLSKLQRKLYQT--------------FLLKKDLNAIKTGEggreIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
213-441 |
2.35e-64 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 213.72 E-value: 2.35e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd17997 4 MRDYQIRGLNWLISLFENGING-ILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGA--ARAAYSRELNslskagKPPPFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSyrwkNLM 370
Cdd:cd17997 83 VLIGDkeERADIIRDVL------LPGKFDVCITSYEMVIK-------EKTVLKKFNWRYIIIDEAHRIKNEKS----KLS 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15226870 371 SVAR--NANQRLMLTGTPLQNDLHELWSLLEFMLPDIFT-TENVD----LKKLLNAEDtELITRMKSILGPFILRRLK 441
Cdd:cd17997 146 QIVRlfNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTsSEDFDewfnVNNCDDDNQ-EVVQRLHKVLRPFLLRRIK 222
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
579-712 |
2.19e-62 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 205.02 E-value: 2.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 579 LSDKHVM-LSAKCRTLAELLPSMKKSGHRVLIFSQWTSMLDILEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKSIF 657
Cdd:cd18793 1 LPPKIEEvVSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIR 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 15226870 658 ACLLSTRAGGQGLNLTGADTVIIHDMDFNPQIDRQAEDRCHRIGQTKPVTIFRLV 712
Cdd:cd18793 81 VFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
212-441 |
2.38e-58 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 197.99 E-value: 2.38e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 212 ILKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLsRLNNDPGPHLVVCPASVLENWERELRKWCPSFTV 291
Cdd:cd18009 3 VMRPYQLEGMEWLRMLWENGING-ILADEMGLGKTIQTIALLAHL-RERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 292 LQYHGAA--RAAYSRELNSlsKAGKPPPFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNL 369
Cdd:cd18009 81 LLYHGTKeeRERLRKKIMK--REGTLQDFPVVVTSYEIAMR-------DRKALQHYAWKYLIVDEGHRLKNLNCRLIQEL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 370 MSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFT--------------TENVDLKKLLNAEDTELITRM-KSILGP 434
Cdd:cd18009 152 KTF--NSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDdlssfeswfdfsslSDNAADISNLSEEREQNIVHMlHAILKP 229
|
....*..
gi 15226870 435 FILRRLK 441
Cdd:cd18009 230 FLLRRLK 236
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
213-441 |
3.45e-58 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 197.59 E-value: 3.45e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd17996 4 LKEYQLKGLQWMVSLYNNNLNG-ILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHG--AARaaysRELNSLSKAGKpppFNVLLVCYslferhsEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSyRWKNLM 370
Cdd:cd17996 83 VYKGtpDVR----KKLQSQIRAGK---FNVLLTTY-------EYIIKDKPLLSKIKWKYMIIDEGHRMKNAQS-KLTQTL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 371 SVARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIF--------------TTENVDLKKLLNAEDTEL-ITRMKSILGPF 435
Cdd:cd17996 148 NTYYHARYRLLLTGTPLQNNLPELWALLNFLLPKIFkscktfeqwfntpfANTGEQVKIELNEEETLLiIRRLHKVLRPF 227
|
....*.
gi 15226870 436 ILRRLK 441
Cdd:cd17996 228 LLRRLK 233
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
209-441 |
1.03e-57 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 195.86 E-value: 1.03e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 209 FQPILKPYQLVGVNFLLLLYKKGIeGAILADEMGLGKTIQAITYLtLLSRLNNDPGPHLVVCPASVLENWERELRKWCPS 288
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGL-GGILADDMGLGKTLQTLALL-LSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 289 FTVLQYHGAARAaySRELNSLSKAgkpppfNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSYRWKN 368
Cdd:cd18012 79 LKVLVIHGTKRK--REKLRALEDY------DLVITSYGLLRR-------DIELLKEVKFHYLVLDEAQNIKNPQTKTAKA 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15226870 369 LMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKK----LLNAEDTELITRMKSILGPFILRRLK 441
Cdd:cd18012 144 VKAL--KADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRfakpIEKDGDEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
213-439 |
6.87e-56 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 190.73 E-value: 6.87e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKkGIEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18006 1 LRPYQLEGVNWLLQCRA-EQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHG--AARAAYSRELNSLskagkpPPFNVLLVCYslferhsEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNL- 369
Cdd:cd18006 80 TYMGdkEKRLDLQQDIKST------NRFHVLLTTY-------EICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLs 146
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15226870 370 -MSVARnanqRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDlkKLLNA-----EDTELITRMKSILGPFILRR 439
Cdd:cd18006 147 eFSVDF----RLLLTGTPIQNSLQELYALLSFIEPNVFPKDKLD--DFIKAysetdDESETVEELHLLLQPFLLRR 216
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
213-439 |
8.29e-55 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 188.10 E-value: 8.29e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGING-ILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAA--RAAYSRELNSLSKAGKPPPFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLM 370
Cdd:cd18002 80 PYWGNPkdRKVLRKFWDRKNLYTRDAPFHVVITSYQLVVQ-------DEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 371 SVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTEN-------VDLKKllNAE-----DTELITRMKSILGPFILR 438
Cdd:cd18002 153 SF--HCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDefnewfsKDIES--HAEnktglNEHQLKRLHMILKPFMLR 228
|
.
gi 15226870 439 R 439
Cdd:cd18002 229 R 229
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
213-439 |
1.52e-54 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 187.18 E-value: 1.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGiEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd17993 2 LRDYQLTGLNWLAHSWCKG-NNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARA-AYSRELNSLSKAGKPPPFNVLLVCYslferhsEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLMS 371
Cdd:cd17993 81 VYLGDIKSrDTIREYEFYFSQTKKLKFNVLLTTY-------EIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKE 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15226870 372 VarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENvDLKKLLNAEDTELITRMKSILGPFILRR 439
Cdd:cd17993 154 F--KTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWE-EFEEEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
213-439 |
7.67e-51 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 177.06 E-value: 7.67e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGiEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPsFTVL 292
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNR-RNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGaarAAYSRELNSLSK-----AGKPPP-----FNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKN 362
Cdd:cd17995 79 VYHG---SGESRQIIQQYEmyfkdAQGRKKkgvykFDVLITTYEMVIA-------DAEELRKIPWRVVVVDEAHRLKNRN 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15226870 363 SYRWKNLMSVARnaNQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRR 439
Cdd:cd17995 149 SKLLQGLKKLTL--EHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFGDLKTAEQVEKLQALLKPYMLRR 223
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
213-451 |
1.31e-48 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 171.77 E-value: 1.31e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGING-ILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHG--AARAAYSRELNslskagKPPPFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSyrwkNLM 370
Cdd:cd18064 95 CLIGdkDQRAAFVRDVL------LPGEWDVCVTSYEMLIK-------EKSVFKKFNWRYLVIDEAHRIKNEKS----KLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 371 SVAR--NANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENvDLKKLLNAE----DTELITRMKSILGPFILRRLKSDV 444
Cdd:cd18064 158 EIVRefKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAE-DFDSWFDTNnclgDQKLVERLHMVLRPFLLRRIKADV 236
|
....*..
gi 15226870 445 MQQLVPK 451
Cdd:cd18064 237 EKSLPPK 243
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
213-441 |
8.42e-47 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 166.35 E-value: 8.42e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNG-ILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHG--AARAAYSRELNslskagKPPPFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSyrwkNLM 370
Cdd:cd18065 95 CLIGdkDARAAFIRDVM------MPGEWDVCVTSYEMVIK-------EKSVFKKFNWRYLVIDEAHRIKNEKS----KLS 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15226870 371 SVAR--NANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTEN-----VDLKKLLNaeDTELITRMKSILGPFILRRLK 441
Cdd:cd18065 158 EIVRefKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADdfdswFDTKNCLG--DQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
213-439 |
5.58e-46 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 162.61 E-value: 5.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEgAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTD-TILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAaraaysrelnslskagkpppfNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLMSV 372
Cdd:cd17994 80 TYVGD---------------------HVLLTSYELISI-------DQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSY 131
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15226870 373 arNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRR 439
Cdd:cd17994 132 --KIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADISKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
213-439 |
7.70e-44 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 157.92 E-value: 7.70e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGiEGAILADEMGLGKTIQAITYLTLL--SRLNNDPgphLVVCPASVLENWERELRKWCPSFT 290
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGG-KGGILADDMGLGKTVQICAFLSGMfdSGLIKSV---LVVMPTSLIPHWVKEFAKWTPGLR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 291 VLQYHGAARAAYSRELNSLSKAGkpppfNVLLVCYSLFERHSEQQKDDRKvlKRWRWSCVLMDEAHALKDKNSYRWKNLM 370
Cdd:cd18001 77 VKVFHGTSKKERERNLERIQRGG-----GVLLTTYGMVLSNTEQLSADDH--DEFKWDYVILDEGHKIKNSKTKSAKSLR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 371 SVarNANQRLMLTGTPLQNDLHELWSLLEF-----MLPDIFTTENVDLKKLLNAED-----------TELITRMKSILGP 434
Cdd:cd18001 150 EI--PAKNRIILTGTPIQNNLKELWALFDFacngsLLGTRKTFKMEFENPITRGRDkdatqgekalgSEVAENLRQIIKP 227
|
....*
gi 15226870 435 FILRR 439
Cdd:cd18001 228 YFLRR 232
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
213-439 |
1.61e-43 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 157.47 E-value: 1.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGiEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18054 21 LRDYQLEGLNWLAHSWCKN-NSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARAAYS-RELNSLSKAGKPPPFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLMS 371
Cdd:cd18054 100 VYIGDLMSRNTiREYEWIHSQTKRLKFNALITTYEILLK-------DKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLID 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15226870 372 VarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTT----ENVDLKKLLNAEDTelitrMKSILGPFILRR 439
Cdd:cd18054 173 F--KSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFwedfEEDHGKGRENGYQS-----LHKVLEPFLLRR 237
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
212-441 |
1.03e-42 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 155.59 E-value: 1.03e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 212 ILKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTV 291
Cdd:cd18062 23 VLKQYQIKGLEWLVSLYNNNLNG-ILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVYEFDKWAPSVVK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 292 LQYHG--AARAAYSRELNSlskaGKpppFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSyRWKNL 369
Cdd:cd18062 102 VSYKGspAARRAFVPQLRS----GK---FNVLLTTYEYIIK-------DKQILAKIRWKYMIVDEGHRMKNHHC-KLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 370 MSVARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIF----------------TTENVDlkklLNAEDTELIT-RMKSIL 432
Cdd:cd18062 167 LNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFkscstfeqwfnapfamTGEKVD----LNEEETILIIrRLHKVL 242
|
....*....
gi 15226870 433 GPFILRRLK 441
Cdd:cd18062 243 RPFLLRRLK 251
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
213-441 |
1.57e-42 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 155.22 E-value: 1.57e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18063 24 LKHYQLQGLEWMVSLYNNNLNG-ILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAarAAYSRELNSLSKAGKpppFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSyRWKNLMSV 372
Cdd:cd18063 103 SYKGT--PAMRRSLVPQLRSGK---FNVLLTTYEYIIK-------DKHILAKIRWKYMIVDEGHRMKNHHC-KLTQVLNT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 373 ARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIF----------------TTENVDlkklLNAEDTELIT-RMKSILGPF 435
Cdd:cd18063 170 HYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFkscstfeqwfnapfamTGERVD----LNEEETILIIrRLHKVLRPF 245
|
....*.
gi 15226870 436 ILRRLK 441
Cdd:cd18063 246 LLRRLK 251
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
213-403 |
4.08e-40 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 146.31 E-value: 4.08e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIeGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSF--T 290
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRV-GGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFrvV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 291 VLQYHGAARAA----YSRELNSLSKAGKPPPFNVLLVCYSLFERHSeqqkddrKVLKRWRWSCVLMDEAHALKDKN---S 363
Cdd:cd18000 80 VLHSSGSGTGSeeklGSIERKSQLIRKVVGDGGILITTYEGFRKHK-------DLLLNHNWQYVILDEGHKIRNPDaeiT 152
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 15226870 364 YRWKNLMSVarnanQRLMLTGTPLQNDLHELWSLLEFMLP 403
Cdd:cd18000 153 LACKQLRTP-----HRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
213-439 |
4.31e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 147.11 E-value: 4.31e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLL-LYKKgiEGAILADEMGLGKTIQAITYLTLLSrLNNDPGPHLVVCPASVLENWERELRKWCpSFTV 291
Cdd:cd18058 1 LREYQLEGMNWLLFnWYNR--KNCILADEMGLGKTIQSITFLSEIF-LMGIRGPFLIIAPLSTITNWEREFRTWT-EMNA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 292 LQYHGAA---RAAYSRELNSLSKAGKPPP----FNVLLVCYslferhsEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSY 364
Cdd:cd18058 77 IVYHGSQisrQMIQQYEMYYRDEQGNPLSgifkFQVVITTF-------EMILADCPELKKINWSCVIIDEAHRLKNRNCK 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15226870 365 RWKNLMSVArnANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRR 439
Cdd:cd18058 150 LLEGLKLMA--LEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
213-439 |
7.98e-40 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 147.14 E-value: 7.98e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGiEGAILADEMGLGKTIQAITYLTLL--------------------SRLNNDPGPHLVVCPA 272
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNG-RGGILGDDMGLGKTVQVIAFLAAVlgktgtrrdrennrprfkkkPPASSAKKPVLIVAPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 273 SVLENWERELRKWcPSFTVLQYHGAARAaysRELNSLSKAGKpppFNVLLVCYSLFERHSEQqkddrkvLKRWRWSCVLM 352
Cdd:cd18005 80 SVLYNWKDELDTW-GHFEVGVYHGSRKD---DELEGRLKAGR---LEVVVTTYDTLRRCIDS-------LNSINWSAVIA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 353 DEAHALKDKNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLP------DIFTTENVDLKKL---LNAEDTE 423
Cdd:cd18005 146 DEAHRIKNPKSKLTQAMKEL--KCKVRIGLTGTLLQNNMKELWCLLDWAVPgalgsrSQFKKHFSEPIKRgqrHTATARE 223
|
250 260
....*....|....*....|..
gi 15226870 424 L------ITRMKSILGPFILRR 439
Cdd:cd18005 224 LrlgrkrKQELAVKLSKFFLRR 245
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
213-439 |
8.99e-40 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 146.66 E-value: 8.99e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLllykkgIEGAILADEMGLGKTIQAI-----------------TYLTLLSRLNNDPGPHLVVCPASVL 275
Cdd:cd18008 1 LLPYQKQGLAWML------PRGGILADEMGLGKTIQALalilatrpqdpkipeelEENSSDPKKLYLSKTTLIVVPLSLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 276 ENWERELRK--WCPSFTVLQYHGAARAAYSRELNSlskagkpppFNVLLVCYSLFERHSEQQKDDRKV---------LKR 344
Cdd:cd18008 75 SQWKDEIEKhtKPGSLKVYVYHGSKRIKSIEELSD---------YDIVITTYGTLASEFPKNKKGGGRdskekeaspLHR 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 345 WRWSCVLMDEAHALKDKNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTE---NVDLKKLLNAED 421
Cdd:cd18008 146 IRWYRVILDEAHNIKNRSTKTSRAVCAL--KAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYpwfNSDISKPFSKND 223
|
250
....*....|....*...
gi 15226870 422 TELITRMKSILGPFILRR 439
Cdd:cd18008 224 RKALERLQALLKPILLRR 241
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
213-439 |
1.02e-39 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 146.36 E-value: 1.02e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEgAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTD-TILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARA-------AYSRELNSLSKAGK--------PPPFNVLLVCYSLFerhseqqKDDRKVLKRWRWSCVLMDEAHA 357
Cdd:cd18057 80 TYTGDKESrsvirenEFSFEDNAIRSGKKvfrmkkeaQIKFHVLLTSYELI-------TIDQAILGSIEWACLVVDEAHR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 358 LKDKNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFIL 437
Cdd:cd18057 153 LKNNQSKFFRVLNSY--KIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHML 230
|
..
gi 15226870 438 RR 439
Cdd:cd18057 231 RR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
213-439 |
4.39e-39 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 144.77 E-value: 4.39e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEgAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTD-TILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHG--AARA-----AYSRELNSLsKAGK---------PPPFNVLLVCYSLFerhseqqKDDRKVLKRWRWSCVLMDEAH 356
Cdd:cd18055 80 TYTGdkDSRAiirenEFSFDDNAV-KGGKkafkmkreaQVKFHVLLTSYELV-------TIDQAALGSIRWACLVVDEAH 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 357 ALKDKNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFI 436
Cdd:cd18055 152 RLKNNQSKFFRVLNGY--KIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHM 229
|
...
gi 15226870 437 LRR 439
Cdd:cd18055 230 LRR 232
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
213-439 |
1.61e-38 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 143.20 E-value: 1.61e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLL--LLYKK--GIEGAILADEMGLGKTIQAITYL-TLLSRLNNDPGPH---LVVCPASVLENWERELRK 284
Cdd:cd18004 1 LRPHQREGVQFLYdcLTGRRgyGGGGAILADEMGLGKTLQAIALVwTLLKQGPYGKPTAkkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 285 WCPS--FTVLQYHGAARAAYSRELNSLSkagkPPPFNVLLVCYSLFERHSEQQKDDRkvlkrwrwSCVLM--DEAHALKD 360
Cdd:cd18004 81 WLGLrrIKVVTADGNAKDVKASLDFFSS----ASTYPVLIISYETLRRHAEKLSKKI--------SIDLLicDEGHRLKN 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 361 KNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTT--------ENVDLKKLL---NAEDTEL-ITRM 428
Cdd:cd18004 149 SESKTTKALNSL--PCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSlasfrkvfEEPILRSRDpdaSEEDKELgAERS 226
|
250
....*....|....
gi 15226870 429 K---SILGPFILRR 439
Cdd:cd18004 227 QelsELTSRFILRR 240
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
213-409 |
9.16e-37 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 138.19 E-value: 9.16e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFL---LLLYKKGIE---GAILADEMGLGKTIQAITYL-TLLSRLNNDPGPhLVVCPASVLENWERELRKW 285
Cdd:cd18007 1 LKPHQVEGVRFLwsnLVGTDVGSDeggGCILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 286 CPSFTVLQYHGAARAAYSRELNSLSKagkpppFN-------VLLVCYSLFER-HSEQQKDDRKVLKRWRWSC------VL 351
Cdd:cd18007 80 LPPDLRPLLVLVSLSASKRADARLRK------INkwhkeggVLLIGYELFRNlASNATTDPRLKQEFIAALLdpgpdlLV 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 15226870 352 MDEAHALKDKNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTE 409
Cdd:cd18007 154 LDEGHRLKNEKSQLSKALSKV--KTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTL 209
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
213-439 |
3.39e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 135.93 E-value: 3.39e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKgIEGAILADEMGLGKTIQAITYLTLLSrLNNDPGPHLVVCPASVLENWERELRKWCpSFTVL 292
Cdd:cd18059 1 LREYQLEGVNWLLFNWYN-TRNCILADEMGLGKTIQSITFLYEIY-LKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAAraAYSRELNSLSKAGKPPPFNVLLVCYSLFERHS--EQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLM 370
Cdd:cd18059 78 VYHGSQ--ASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITtfEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLK 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15226870 371 SVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRR 439
Cdd:cd18059 156 MM--DLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
213-439 |
5.12e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 135.57 E-value: 5.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLL-LYKKgiEGAILADEMGLGKTIQAITYLTLLSRLNNDpGPHLVVCPASVLENWERELRKWCPSFTV 291
Cdd:cd18060 1 LREYQLEGVNWLLFnWYNR--QNCILADEMGLGKTIQSIAFLQEVYNVGIH-GPFLVIAPLSTITNWEREFNTWTEMNTI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 292 LqYHG--AARAAYSR-ELNSLSKAGKPPP----FNVLLVCYslferhsEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSY 364
Cdd:cd18060 78 V-YHGslASRQMIQQyEMYCKDSRGRLIPgaykFDALITTF-------EMILSDCPELREIEWRCVIIDEAHRLKNRNCK 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15226870 365 RWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRR 439
Cdd:cd18060 150 LLDSLKHM--DLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
213-439 |
7.56e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 135.58 E-value: 7.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEgAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTD-TILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHG--AARA-----AYSRELNSLSKAGKPP--------PFNVLLVCYSLFerhseqqKDDRKVLKRWRWSCVLMDEAHA 357
Cdd:cd18056 80 TYVGdkDSRAiirenEFSFEDNAIRGGKKASrmkkeasvKFHVLLTSYELI-------TIDMAILGSIDWACLIVDEAHR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 358 LKDKNSYRWKNLMSVArnANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFIL 437
Cdd:cd18056 153 LKNNQSKFFRVLNGYS--LQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHML 230
|
..
gi 15226870 438 RR 439
Cdd:cd18056 231 RR 232
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
213-439 |
8.01e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 135.56 E-value: 8.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGiEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVL 292
Cdd:cd18053 21 LRDYQLNGLNWLAHSWCKG-NSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARAA-YSRELNSLSKAGKPPPFNVLLVCYSLFERhseqqkdDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLMS 371
Cdd:cd18053 100 VYLGDINSRnMIRTHEWMHPQTKRLKFNILLTTYEILLK-------DKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLID 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15226870 372 VarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSiLGPFILRR 439
Cdd:cd18053 173 F--KSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASLHKE-LEPFLLRR 237
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
213-439 |
1.52e-35 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 134.40 E-value: 1.52e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGaILADEMGLGKTIQAITYLTLLSRL-----NNDPGPHLVVCPASVLENWERELRKWCP 287
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHG-ILCDDMGLGKTLQTLCILASDHHKransfNSENLPSLVVCPPTLVGHWVAEIKKYFP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 288 SF--TVLQYHGAArAAYSRELNSLSKAgkpppfNVLLVCYslferhsEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYR 365
Cdd:cd17999 80 NAflKPLAYVGPP-QERRRLREQGEKH------NVIVASY-------DVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 366 WKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENV----DLKKLL-------NAEDTEL----ITRM-K 429
Cdd:cd17999 146 SKAVKQL--KANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQfqrrFLKPILasrdskaSAKEQEAgalaLEALhK 223
|
250
....*....|
gi 15226870 430 SILgPFILRR 439
Cdd:cd17999 224 QVL-PFLLRR 232
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
213-410 |
1.44e-33 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 128.09 E-value: 1.44e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLllYKKGieGAILADEMGLGKTIQAITyltLLSRLNNDpGPHLVVCPASVLENWERELRKWCPSFTVl 292
Cdd:cd18010 1 LLPFQREGVCFAL--RRGG--RVLIADEMGLGKTVQAIA---IAAYYREE-WPLLIVCPSSLRLTWADEIERWLPSLPP- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 qyhgaaraaysRELNSLSKAG---KPPPFNVLLVCYSLFERHSEQqkddrkvLKRWRWSCVLMDEAHALKDKNSYRWKNL 369
Cdd:cd18010 72 -----------DDIQVIVKSKdglRDGDAKVVIVSYDLLRRLEKQ-------LLARKFKVVICDESHYLKNSKAKRTKAA 133
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15226870 370 MSVARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTEN 410
Cdd:cd18010 134 LPLLKRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFH 174
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
213-439 |
3.07e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 124.73 E-value: 3.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLL-LYKKgiEGAILADEMGLGKTIQAITYLTLLSRlNNDPGPHLVVCPASVLENWERELRKWCpSFTV 291
Cdd:cd18061 1 LREYQLEGLNWLLFnWYNR--RNCILADEMGLGKTIQSITFLYEILL-TGIRGPFLIIAPLSTIANWEREFRTWT-DLNV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 292 LQYHGAA---RAAYSRELNSLSKAGK----PPPFNVLLVCYSLFERHSEQqkddrkvLKRWRWSCVLMDEAHALKDKNSY 364
Cdd:cd18061 77 VVYHGSLisrQMIQQYEMYFRDSQGRiirgAYRFQAIITTFEMILGGCPE-------LNAIDWRCVIIDEAHRLKNKNCK 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15226870 365 RWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRR 439
Cdd:cd18061 150 LLEGLKLM--NLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
213-439 |
6.58e-32 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 124.50 E-value: 6.58e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLlllYK-------KGIEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHL----VVCPASVLENWERE 281
Cdd:cd18067 1 LRPHQREGVKFL---YRcvtgrriRGSHGCIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 282 LRKWC-PSFTVLQYHGAARAAYSREL-NSLSKAGKPPPFNVLLVCYSLFERHSEQqkddrkvLKRWRWSCVLMDEAHALK 359
Cdd:cd18067 78 LGKWLgGRLQPLAIDGGSKKEIDRKLvQWASQQGRRVSTPVLIISYETFRLHVEV-------LQKGEVGLVICDEGHRLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 360 DKNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTT-----ENVDLKKL-------LNAEDTELITR 427
Cdd:cd18067 151 NSDNQTYQALDSL--NTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTaaefkKNFELPILkgrdadaSEKERQLGEEK 228
|
250
....*....|....*
gi 15226870 428 MK---SILGPFILRR 439
Cdd:cd18067 229 LQeliSIVNRCIIRR 243
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
213-439 |
2.07e-29 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 116.87 E-value: 2.07e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFL----LLLYKKGIEGAILADEMGLGKTIQAITYLTLLSRLNNDPGP-----HLVVCPASVLENWERELR 283
Cdd:cd18066 1 LRPHQREGIEFLyecvMGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvikrALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 284 KWCPS-----FTVLQYHGAARAAYSrelnslskagkpPPFNVLLVCYSLFERHSEQqkddrkvLKRWRWSCVLMDEAHAL 358
Cdd:cd18066 81 KWLGSerikvFTVDQDHKVEEFIAS------------PLYSVLIISYEMLLRSLDQ-------ISKLNFDLVICDEGHRL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 359 KDKNSYRWKNLMSVArnANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENV-------------------DLKKLLNA 419
Cdd:cd18066 142 KNTSIKTTTALTSLS--CERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTyrkvyeepivrsreptatpEEKKLGEA 219
|
250 260
....*....|....*....|
gi 15226870 420 EDTELiTRMksiLGPFILRR 439
Cdd:cd18066 220 RAAEL-TRL---TGLFILRR 235
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
213-412 |
7.46e-29 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 114.13 E-value: 7.46e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLllykKGIEGAILADEMGLGKTIQAITYLtLLSRLNNDPGPHLVVCPASVL-ENWERELRKWCPSF-- 289
Cdd:smart00487 9 LRPYQKEAIEALL----SGLRDVILAAPTGSGKTLAALLPA-LEALKRGKGGRVLVLVPTRELaEQWAEELKKLGPSLgl 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 290 -TVLQYHGAARAAYSRELNSlskagkpPPFNVLLVCYSLFERHSEQQKDDRKvlkrwRWSCVLMDEAHALKDKNSYR-WK 367
Cdd:smart00487 84 kVVGLYGGDSKREQLRKLES-------GKTDILVTTPGRLLDLLENDKLSLS-----NVDLVILDEAHRLLDGGFGDqLE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 15226870 368 NLMSVARNANQRLMLTGTP---LQNDLHELWSLLEFMLPDIFTTENVD 412
Cdd:smart00487 152 KLLKLLPKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEPIE 199
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
588-701 |
1.12e-26 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 104.99 E-value: 1.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 588 AKCRTLAELLPsmKKSGHRVLIFSQWTSMLDIlEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKSIFacLLSTRAGG 667
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDV--LVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 15226870 668 QGLNLTGADTVIIHDMDFNPQIDRQAEDRCHRIG 701
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
213-407 |
1.26e-25 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 105.06 E-value: 1.26e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLlykKGIEGAILADEMGLGKTIQAITYLTLLsRLNNDPGPHLVVCPASVLENWERELRKwcpsftvl 292
Cdd:cd18011 1 PLPHQIDAVLRALR---KPPVRLLLADEVGLGKTIEAGLIIKEL-LLRGDAKRVLILCPASLVEQWQDELQD-------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 293 QYHGAARAAYSRELNSLSKAGKPPPFNVLLVCYSLFERHSeqQKDDRKVLKRWRWSCVLMDEAHALKDKN----SYRWKN 368
Cdd:cd18011 69 KFGLPFLILDRETAAQLRRLIGNPFEEFPIVIVSLDLLKR--SEERRGLLLSEEWDLVVVDEAHKLRNSGggkeTKRYKL 146
|
170 180 190
....*....|....*....|....*....|....*....
gi 15226870 369 LMSVARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFT 407
Cdd:cd18011 147 GRLLAKRARHVLLLTATPHNGKEEDFRALLSLLDPGRFA 185
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
234-401 |
1.52e-24 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 102.93 E-value: 1.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 234 GAILADEMGLGKTIQAITYLtllsrLNNdpgPHLVVCPASVLENWERELRKWCPS--FTVLQYHGAARaaySRELNSLSK 311
Cdd:cd18071 50 GGILADDMGLGKTLTTISLI-----LAN---FTLIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGGER---NRDPKLLSK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 312 agkpppFNVLLVCYSLFErHSEQQKDDRKvLKRWRWSCVLMDEAHALKDKNSYRWKNLMSVarNANQRLMLTGTPLQNDL 391
Cdd:cd18071 119 ------YDIVLTTYNTLA-SDFGAKGDSP-LHTINWLRVVLDEGHQIRNPNAQQTKAVLNL--SSERRWVLTGTPIQNSP 188
|
170
....*....|
gi 15226870 392 HELWSLLEFM 401
Cdd:cd18071 189 KDLGSLLSFL 198
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
213-439 |
1.29e-21 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 94.47 E-value: 1.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGAILADEMGLGKTIQAITyLTLLSRLNND-----------------------PGPHLVV 269
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGGILADDMGLGKTLTMIA-LILAQKNTQNrkeeekekalteweskkdstlvpSAGTLVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 270 CPASVLENWERELRKWCPS--FTVLQYHGAARAAYSRELNSlskagkpppFNVLLVCYSLFERHSEQQKDDRKV--LKRW 345
Cdd:cd18072 80 CPASLVHQWKNEVESRVASnkLRVCLYHGPNRERIGEVLRD---------YDIVITTYSLVAKEIPTYKEESRSspLFRI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 346 RWSCVLMDEAHALKDKNSyrwKNLMSVAR-NANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVdLKKLLNAEDTEL 424
Cdd:cd18072 151 AWARIILDEAHNIKNPKV---QASIAVCKlRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKV-WKKQVDNKSRKG 226
|
250
....*....|....*
gi 15226870 425 ITRMKSILGPFILRR 439
Cdd:cd18072 227 GERLNILTKSLLLRR 241
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
213-408 |
1.16e-19 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 88.72 E-value: 1.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLlllYKKGIE-----------GAILADEMGLGKTIQAITYLTLLSRlNNDPGPHLVVCPASVLENWERE 281
Cdd:cd18069 1 LKPHQIGGIRFL---YDNIIEslerykgssgfGCILAHSMGLGKTLQVISFLDVLLR-HTGAKTVLAIVPVNTLQNWLSE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 282 LRKWCPSFT-------------VLQYHGAARAAYSRELNSLSKAGkpppfNVLLVCYSLFerhseQQKDDRKVlkrwrws 348
Cdd:cd18069 77 FNKWLPPPEalpnvrprpfkvfILNDEHKTTAARAKVIEDWVKDG-----GVLLMGYEMF-----RLRPGPDV------- 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 349 cVLMDEAHALKDKNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTT 408
Cdd:cd18069 140 -VICDEGHRIKNCHASTSQALKNI--RSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGT 196
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
618-701 |
2.89e-19 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 82.64 E-value: 2.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 618 DILEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKSIFacLLSTRAGGQGLNLTGADTVIIHDMDFNPQIDRQAEDRC 697
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKV--LVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 15226870 698 HRIG 701
Cdd:smart00490 79 GRAG 82
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
213-408 |
4.97e-19 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 87.25 E-value: 4.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNF--------LLLLYKKGIEGAILADEMGLGKTIQAITYL--TLLSRLNNDPGPHLVVCPASVLENWEREL 282
Cdd:cd18068 1 LKPHQVDGVQFmwdcccesLKKTKKSPGSGCILAHCMGLGKTLQVVTFLhtVLLCEKLENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 283 RKWcpsftvlqyHGAARAAYSRELNSLSKAGKPPP--------FN---VLLVCYSLFE--------RHSEQQKDD-RKVL 342
Cdd:cd18068 81 EKW---------QEGLKDEEKIEVNELATYKRPQErsyklqrwQEeggVMIIGYDMYRilaqernvKSREKLKEIfNKAL 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15226870 343 KRWRWSCVLMDEAHALKDKNSYRWKNLMSVarNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTT 408
Cdd:cd18068 152 VDPGPDFVVCDEGHILKNEASAVSKAMNSI--RTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGT 215
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
213-396 |
1.60e-17 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 82.01 E-value: 1.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLllykKGIEGAILADeMGLGKTIQAITYLTLLsRLNNDPGPHLVVCPASVLEN-WERELRKW--CPSF 289
Cdd:cd18013 1 PHPYQKVAINFII----EHPYCGLFLD-MGLGKTVTTLTALSDL-QLDDFTRRVLVIAPLRVARStWPDEVEKWnhLRNL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 290 TVLQYHGAARAaysrelnsLSKAGKPPPfnvllvcySLFERHSEQQKD-DRKVLKRWRWSCVLMDEAHALKDKNSYRWKN 368
Cdd:cd18013 75 TVSVAVGTERQ--------RSKAANTPA--------DLYVINRENLKWlVNKSGDPWPFDMVVIDELSSFKSPRSKRFKA 138
|
170 180
....*....|....*....|....*...
gi 15226870 369 LMSVARNANQRLMLTGTPLQNDLHELWS 396
Cdd:cd18013 139 LRKVRPVIKRLIGLTGTPSPNGLMDLWA 166
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
213-407 |
2.07e-15 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 77.00 E-value: 2.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLykkgieGAILADEMGLGKTIQAITyLTLLSRLNNDP--------------------------GPH 266
Cdd:cd18070 1 LLPYQRRAVNWMLVP------GGILADEMGLGKTVEVLA-LILLHPRPDNDldaadddsdemvccpdclvaetpvssKAT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 267 LVVCPASVLENWERELRKWCP-SFTVLQYHGAaraaysrelNSLSKAGKPPP------------FNVLL--VCYSLFERH 331
Cdd:cd18070 74 LIVCPSAILAQWLDEINRHVPsSLKVLTYQGV---------KKDGALASPAPeilaeydivvttYDVLRteLHYAEANRS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 332 SEQQKDDRKV------LKRWRWSCVLMDEAHALKDKNSyrwkNLMSVARN--ANQRLMLTGTPLQNDLHELWSLLEFMLP 403
Cdd:cd18070 145 NRRRRRQKRYeappspLVLVEWWRVCLDEAQMVESSTS----KAAEMARRlpRVNRWCVSGTPIQRGLDDLFGLLSFLGV 220
|
....
gi 15226870 404 DIFT 407
Cdd:cd18070 221 EPFC 224
|
|
| DpdE |
NF041062 |
protein DpdE; |
237-712 |
6.23e-07 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 53.05 E-value: 6.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 237 LADEMGLGKTIQAitYLTLLSRLNNDPGPH-LVVCPASVLENWERELR-KWCpsftvlqyhgaaraaysreLNSLSKAGk 314
Cdd:NF041062 175 LADEVGLGKTIEA--GLVIRQHLLDNPDARvLVLVPDALVRQWRRELRdKFF-------------------LDDFPGAR- 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 315 pppFNVLlvcyslfeRHSEQQKddrkvLKRWRWSCVLM--DEAHAL-------KDKNSYRWKNLMSVARNANQRLMLTGT 385
Cdd:NF041062 233 ---VRVL--------SHEEPER-----WEPLLDAPDLLvvDEAHQLarlawsgDPPERARYRELAALAHAAPRLLLLSAT 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 386 PLQND-------LHEL------WSLLE-------------------------FMLPDIFTtenvDLKKLLnAEDTE---L 424
Cdd:NF041062 297 PVLGNeetflalLHLLdpdlypLDDLEafrerleereelgrlvlgldpdnpnFLLRQALD----ELRALF-PEDEElqeL 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 425 ITRMKSILGPF----------------------------ILRRLKSDVMQQ--LVPKIQRVEYVLMERKQEDAYKEAIEE 474
Cdd:NF041062 372 AEELLPLLDEFddeepeeraravsalrahisetyrlhrrMIRNRRSSVLGAdyLVPGRAGPRVLVWESPAREAADEALED 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 475 YRaaSQARLVKLSSKSLnslakalpkrQISNYFTQFrkianhPLLIRRIYSDEDVIRIARKLhpigafgfecsLDRVIEE 554
Cdd:NF041062 452 WR--EEAALLDAESDPA----------ARAAYARAL------AWLVARLGGPDDLAALLRWR-----------LRGDAAS 502
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 555 VkgfnDFRIHQLLFQYGVNDTKGTLSDKHVMlsakcRTLAELLPSMKKSGHRVLIFSQWTSMLDILEWTLDVIGVT--YR 632
Cdd:NF041062 503 A----DLAGERELLEALIAALEDEAKDADLL-----AALADWLLPLLRGSGKAVVFCGDGSLADHLAAALARLGAGsvER 573
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 633 RLDGSTqVTDRQTIVDTFNNDKSIfACLLSTRAGGQGLNLTGADTVIIHDMDFNPQ-----IDRQaeDRCHRIGQTKPVT 707
Cdd:NF041062 574 HLSGQG-ADQAERAVRAFRQDPSA-RVLVCDRSGEEGLNLQGADRLVHLDLPWSPNrleqrIGRL--DRYASLRGGRPVE 649
|
....*
gi 15226870 708 IFRLV 712
Cdd:NF041062 650 SYVLA 654
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
233-360 |
6.50e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 43.55 E-value: 6.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 233 EGAILADEMGLGKTIQAitYLTLLSRLNNDPGPHLVVCPASVLEN-WERELRKWCPSFTVLQYHGAARAAYSRELNSLSK 311
Cdd:cd00046 2 ENVLITAPTGSGKTLAA--LLAALLLLLKKGKKVLVLVPTKALALqTAERLRELFGPGIRVAVLVGGSSAEEREKNKLGD 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 15226870 312 AgkpppfNVLLVCYSLFERHSEQqkDDRKVLKRWRWscVLMDEAHALKD 360
Cdd:cd00046 80 A------DIIIATPDMLLNLLLR--EDRLFLKDLKL--IIVDEAHALLI 118
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
593-703 |
7.39e-04 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 42.84 E-value: 7.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 593 LAELLPSMKKSGHRVLIFSQWTSMLDILEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKSifACLLSTRAGGQGLNL 672
Cdd:PTZ00110 366 LKMLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKS--PIMIATDVASRGLDV 443
|
90 100 110
....*....|....*....|....*....|.
gi 15226870 673 TGADTVIihDMDFNPQIdrqaEDRCHRIGQT 703
Cdd:PTZ00110 444 KDVKYVI--NFDFPNQI----EDYVHRIGRT 468
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
205-443 |
2.69e-03 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 41.16 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 205 EDSDFQPILKPYQLVGVNFLLLLYKKGIEGAILADEMGLGKTI---QAITYLTLLSRLnndpgphLVVCP-ASVLENWER 280
Cdd:COG1061 73 EASGTSFELRPYQQEALEALLAALERGGGRGLVVAPTGTGKTVlalALAAELLRGKRV-------LVLVPrRELLEQWAE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 281 ELRKWCPSFTVLQYHgaaraaysrelnslskagKPPPFNVLLVCYSLFERHseqqkDDRKVLKRwRWSCVLMDEAHALkd 360
Cdd:COG1061 146 ELRRFLGDPLAGGGK------------------KDSDAPITVATYQSLARR-----AHLDELGD-RFGLVIIDEAHHA-- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 361 kNSYRWKNLMSvARNANQRLMLTGTPLQNDLHElwsLLEFMLPDIftTENVDLKKLLNAEdtelitrmksILGPFILRRL 440
Cdd:COG1061 200 -GAPSYRRILE-AFPAAYRLGLTATPFRSDGRE---ILLFLFDGI--VYEYSLKEAIEDG----------YLAPPEYYGI 262
|
...
gi 15226870 441 KSD 443
Cdd:COG1061 263 RVD 265
|
|
| HgdB |
COG1775 |
Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid ... |
291-399 |
3.54e-03 |
|
Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 441381 Cd Length: 384 Bit Score: 40.27 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 291 VLQYHGAARAAYsRELNSLSKAgKPPP---FNVLLVCYSLF----ERHSEQQKDdrkvlkrwrwscvLMDEahaLKDkns 363
Cdd:COG1775 166 AIKLYNEARKLL-RELYELRKA-KPPPisgFDLLLVMAAAFfmdkEEATELLEE-------------LLDE---LEE--- 224
|
90 100 110
....*....|....*....|....*....|....*.
gi 15226870 364 yRWKNLMSVARNANQRLMLTGTPLQNDLHELWSLLE 399
Cdd:COG1775 225 -RIAEGIGAVPEEKPRILWTGIPPWPPNRKLLKLIE 259
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
213-386 |
6.33e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 38.04 E-value: 6.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 213 LKPYQLVGVNFLLLLYKKGIEGAILADEMGLGKTI---QAITYLTLLSRLNNdpgpHLVVCP-ASVLENWERELRKWCPS 288
Cdd:pfam04851 4 LRPYQIEAIENLLESIKNGQKRGLIVMATGSGKTLtaaKLIARLFKKGPIKK----VLFLVPrKDLLEQALEEFKKFLPN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226870 289 ftvlqYHGAaraaySRELNSLSKAGKPPPFNVLLVCYSLFERHSEQQKDDrkvLKRWRWSCVLMDEAHALKDKNsyrWKN 368
Cdd:pfam04851 80 -----YVEI-----GEIISGDKKDESVDDNKIVVTTIQSLYKALELASLE---LLPDFFDVIIIDEAHRSGASS---YRN 143
|
170
....*....|....*...
gi 15226870 369 LMSvARNANQRLMLTGTP 386
Cdd:pfam04851 144 ILE-YFKPAFLLGLTATP 160
|
|
| |
