|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
27-463 |
6.58e-172 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 490.16 E-value: 6.58e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 27 ELKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSGFSIMFGLVGSLETLSGQAYGAKQYEKMG 106
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 107 TYTYSAISSNIPICVLISILWIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALT 186
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 187 TLLFHIAVCWTLVSALGLGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVKQFFRYGVPSAAMLCLE 266
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 267 WWLFELLILCSGLLQnPKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFS 346
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 347 ILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPVGIYLAFSC 426
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 186499234 427 ELNGKGLWCGVVVGSAVQAIILAIVTASMNWKEQAKK 463
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
37-377 |
1.54e-50 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 175.13 E-value: 1.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 37 PMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVsGFSIMFGLVGSLETLSGQAYGAKQYEKMGTYTYSAISSN 116
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMF-LFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 117 IPICVLISILWIYMEKLLISLGQ-DPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTTLLFHIAVC 195
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 196 WTLVSAL--GLGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVKQFFRYGVPSAAMLCLEWWLFELL 273
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 274 ILCSGLLQnpKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFSILLFAFR 353
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....
gi 186499234 354 NIIGYAFSNSKEVVDYVADLSPLL 377
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFV 341
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
28-450 |
1.22e-46 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 166.86 E-value: 1.22e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 28 LKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSgFSIMFGLVGSLETLSGQAYGAKQYEKMGT 107
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 108 YTYSAISSNIPICVLISIL-WIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALT 186
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 187 TLLFHIAVCWTLVSALGLGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVKQFFRYGVPSAAMLCLE 266
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 267 WWLFELLILCSGLLQNpkLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFS 346
Cdd:COG0534 246 SLGFLVLNALVARLGT--AAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 347 ILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPVGIYLAFSc 426
Cdd:COG0534 324 LLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFL- 402
|
410 420
....*....|....*....|....
gi 186499234 427 ELNGKGLWCGVVVGSAVQAIILAI 450
Cdd:COG0534 403 GLGLTGVWLALPIGEVLRALLLLL 426
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
23-450 |
7.25e-26 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 109.52 E-value: 7.25e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 23 QLNVELKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTnvsgFSIMFGLVGSLETLS---GQAYGA 99
Cdd:PRK01766 6 KYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW----LPVILFGHGLLLALTpivAQLNGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 100 KQYEKMGTYTYSAISSNIPICVLI-SILWIYMEKLLISLGQDPDISRVAGSY--ALRL-IPTLFAHAIvlpLTRFLLAQG 175
Cdd:PRK01766 82 GRRERIAHQVRQGLWLALFLSVLImLVLYNAVPPILNMMNLEPEVADIAVGYlhALLWgIPAYLLYQV---LRSFIDGLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 176 LVLPLLYFALTTLLFHIAVCWTLV-SALG---LGSNGAALAISVSFWFFAMTLSCYVRFS---SSCEKTRRFVSQDFlSS 248
Cdd:PRK01766 159 KTKPTMVIGFLGLLINIPLNYIFIyGKFGfpeLGGVGCGVATAIVYWVMFLAMLIYIKRArrfRDFRLFKGLYKPDW-AV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 249 VKQFFRYGVPSAAMLCLEWWLFELLilcsGLLQNPKLETSVLS--ICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQV 326
Cdd:PRK01766 238 IKRLLKLGLPIGLAIFFEVSLFAVV----TLLVSPLGTVTVAAhqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 327 ARVSVLAGLCLWLVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSpLLCLSFVL-DGFTAVLNGVARGCGWQHIGAL 405
Cdd:PRK01766 314 ARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLL-LFAALFQFsDAIQVIGSGALRGYKDTRVIFF 392
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 186499234 406 NNVVAYYLVGAPVGIYLAFSCELNGKGLWCGVVVGSAVQAIILAI 450
Cdd:PRK01766 393 ITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
37-197 |
2.09e-21 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 90.70 E-value: 2.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 37 PMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSgFSIMFGLVGSLETLSGQAYGAKQYEKMGTYTYSAISSN 116
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 117 IPICVLISIL-WIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTTLLFHIAVC 195
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 186499234 196 WT 197
Cdd:pfam01554 160 YL 161
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
27-463 |
6.58e-172 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 490.16 E-value: 6.58e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 27 ELKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSGFSIMFGLVGSLETLSGQAYGAKQYEKMG 106
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 107 TYTYSAISSNIPICVLISILWIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALT 186
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 187 TLLFHIAVCWTLVSALGLGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVKQFFRYGVPSAAMLCLE 266
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 267 WWLFELLILCSGLLQnPKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFS 346
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 347 ILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPVGIYLAFSC 426
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 186499234 427 ELNGKGLWCGVVVGSAVQAIILAIVTASMNWKEQAKK 463
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
27-450 |
1.31e-51 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 180.39 E-value: 1.31e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 27 ELKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSgFSIMFGLVGSLETLSGQAYGAKQYEKMG 106
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 107 TYTYSAISSNIPICVLISILWIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALT 186
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 187 TLLFHIAVCWTLVSALG----LGSNGAALAISVSFWFFAMTLSCYVRFSsscEKTRRF-VSQDF----LSSVKQFFRYGV 257
Cdd:cd13131 160 ALVLNIPLNYVLIFGKFglpaLGGAGAGLATAIVYWLMFLALAFYIRRH---KRFRRYrLFARFwrpdWARLKELLRLGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 258 PSAAMLCLEWWLFELLILCSGllqnpKLETSVLS---ICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAG 334
Cdd:cd13131 237 PIGLTIFFEVSLFAAVALLMG-----RLGTTVLAahqIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 335 LCLWLVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLV 414
Cdd:cd13131 312 LGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGI 391
|
410 420 430
....*....|....*....|....*....|....*.
gi 186499234 415 GAPVGIYLAFSCELNGKGLWCGVVVGSAVQAIILAI 450
Cdd:cd13131 392 GLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLW 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
37-377 |
1.54e-50 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 175.13 E-value: 1.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 37 PMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVsGFSIMFGLVGSLETLSGQAYGAKQYEKMGTYTYSAISSN 116
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMF-LFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 117 IPICVLISILWIYMEKLLISLGQ-DPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTTLLFHIAVC 195
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 196 WTLVSAL--GLGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVKQFFRYGVPSAAMLCLEWWLFELL 273
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 274 ILCSGLLQnpKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFSILLFAFR 353
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....
gi 186499234 354 NIIGYAFSNSKEVVDYVADLSPLL 377
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFV 341
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
28-450 |
1.22e-46 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 166.86 E-value: 1.22e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 28 LKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSgFSIMFGLVGSLETLSGQAYGAKQYEKMGT 107
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 108 YTYSAISSNIPICVLISIL-WIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALT 186
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 187 TLLFHIAVCWTLVSALGLGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVKQFFRYGVPSAAMLCLE 266
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 267 WWLFELLILCSGLLQNpkLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFS 346
Cdd:COG0534 246 SLGFLVLNALVARLGT--AAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 347 ILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPVGIYLAFSc 426
Cdd:COG0534 324 LLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFL- 402
|
410 420
....*....|....*....|....
gi 186499234 427 ELNGKGLWCGVVVGSAVQAIILAI 450
Cdd:COG0534 403 GLGLTGVWLALPIGEVLRALLLLL 426
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
29-458 |
2.35e-32 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 128.01 E-value: 2.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 29 KKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVsGFSIMFGLVGSLETLSGQAYGAKQYEKMGTY 108
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWL-LLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 109 TYSAISSNIPICVLISILWIYMEKLLISL-GQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTT 187
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLLFAEPLLRLlGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 188 LLFHIAVCWTLV----SALGLGSNGAALAISVSfWFFAMTLSCYVRFSSSCEKTRRFVSQDF-LSSVKQFFRYGVPSAAM 262
Cdd:cd13137 160 NVLNIVLDYVLIfglwGFPGLGVAGAALATVIS-RVVGALLLLFLLLRGRLPIKISFKGFRLdRKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 263 LcLEWWLFELLILcSGLLQNPKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVES 342
Cdd:cd13137 239 Q-LLRSLGFLVLL-AIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFM 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 343 SFFSILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPVGIYL 422
Cdd:cd13137 317 GLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLL 396
|
410 420 430
....*....|....*....|....*....|....*.
gi 186499234 423 AFSCELNGKGLWCGVVVGSAVQAIILAIVTASMNWK 458
Cdd:cd13137 397 GFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
35-451 |
2.00e-29 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 119.35 E-value: 2.00e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 35 AVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSGFSIMFGLVGsLETLSGQAYGAKQYEKMGTYTYSAIS 114
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVG-TSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 115 SNIPICVLISILWIYMEKLLISL-GQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTTLLFHI- 192
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLlGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIl 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 193 --AVCWTLVSALGLGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVKQFFRYGVPSAAMLCLEWWLF 270
Cdd:cd12082 160 ldPLLIFGLGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 271 ELLILCSGLLQNPkLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFSILLF 350
Cdd:cd12082 240 LIIVAIVAAFGGA-AALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 351 AFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPVGiYLAFSCELNG 430
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLA-YVLAYLGLGL 397
|
410 420
....*....|....*....|.
gi 186499234 431 KGLWCGVVVGSAVQAIILAIV 451
Cdd:cd12082 398 YGIWLALVISLILAALVLLLF 418
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
23-450 |
7.25e-26 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 109.52 E-value: 7.25e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 23 QLNVELKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTnvsgFSIMFGLVGSLETLS---GQAYGA 99
Cdd:PRK01766 6 KYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW----LPVILFGHGLLLALTpivAQLNGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 100 KQYEKMGTYTYSAISSNIPICVLI-SILWIYMEKLLISLGQDPDISRVAGSY--ALRL-IPTLFAHAIvlpLTRFLLAQG 175
Cdd:PRK01766 82 GRRERIAHQVRQGLWLALFLSVLImLVLYNAVPPILNMMNLEPEVADIAVGYlhALLWgIPAYLLYQV---LRSFIDGLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 176 LVLPLLYFALTTLLFHIAVCWTLV-SALG---LGSNGAALAISVSFWFFAMTLSCYVRFS---SSCEKTRRFVSQDFlSS 248
Cdd:PRK01766 159 KTKPTMVIGFLGLLINIPLNYIFIyGKFGfpeLGGVGCGVATAIVYWVMFLAMLIYIKRArrfRDFRLFKGLYKPDW-AV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 249 VKQFFRYGVPSAAMLCLEWWLFELLilcsGLLQNPKLETSVLS--ICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQV 326
Cdd:PRK01766 238 IKRLLKLGLPIGLAIFFEVSLFAVV----TLLVSPLGTVTVAAhqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 327 ARVSVLAGLCLWLVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSpLLCLSFVL-DGFTAVLNGVARGCGWQHIGAL 405
Cdd:PRK01766 314 ARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLL-LFAALFQFsDAIQVIGSGALRGYKDTRVIFF 392
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 186499234 406 NNVVAYYLVGAPVGIYLAFSCELNGKGLWCGVVVGSAVQAIILAI 450
Cdd:PRK01766 393 ITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
28-457 |
1.35e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 105.69 E-value: 1.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 28 LKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALAtSFTNVSGFSIMFGLVGSLETLSGQAYGAKQYEKMGT 107
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 108 YTYSAISSNIPICVLISILWIYMEKLLISL-GQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALT 186
Cdd:cd13133 83 VLWQGLYFSLLLAPLLALLSALAAPLLFLLlGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 187 TLLFHIAVCWTLV-SALG---LGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDF-LSSVKQFFRYGVPSAA 261
Cdd:cd13133 163 MVVVNIVLDYALIfGKLGfpaMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFdRELLRRILRLGLPSGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 262 MLCLEWWLFELLILCSGLLQnpKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVE 341
Cdd:cd13133 243 QFFLDVGAFTVFFLLIGRLG--TTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 342 SSFFSILLFAFRNIIGYAFSN---SKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPV 418
Cdd:cd13133 321 MLLLGILFLLFPELLLSIFTPgadFALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPP 400
|
410 420 430
....*....|....*....|....*....|....*....
gi 186499234 419 GIYLAFScELNGKGLWCGVVVGSAVQAIILAIVTASMNW 457
Cdd:cd13133 401 AYLLVVL-GAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
37-197 |
2.09e-21 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 90.70 E-value: 2.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 37 PMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSgFSIMFGLVGSLETLSGQAYGAKQYEKMGTYTYSAISSN 116
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 117 IPICVLISIL-WIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTTLLFHIAVC 195
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 186499234 196 WT 197
Cdd:pfam01554 160 YL 161
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
28-458 |
2.80e-21 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 95.99 E-value: 2.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 28 LKKVSRLAVPMATVTIAQYLLPVISVMVAGH-NGELQLSGVALATSFTN-VSGFSIMFGLVGSLetLSGQAYGAKQYEKM 105
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFlLTAIGMGLSMGGTI--LISQYIGAKDEEKA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 106 GTYTYSAISSNIPICVLISIL-WIYMEKLLISLGQDPDISRVAGSYaLRL----IPTLFAHAIvlpLTRFLLAQGLVLPL 180
Cdd:cd13138 80 KKAVGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSY-LRIcflgIPFIFGYNA---YSAILRGLGDSKTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 181 LYFALTTLLFHIAVCWTLVSALGLGSNGAALA--ISVSFWFFAMTLscYVRFSSSCEK-TRRFVSQDFlSSVKQFFRYGV 257
Cdd:cd13138 156 LYFVIIACVLNIILDLLFIAVFHMGVAGAALAtvIAQAISVLLALY--YLRKKKLPFKlSLKDFRFDK-EILKEILKIGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 258 PSAAMLCLEwwLFELLILCSGLLQNPKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCL 337
Cdd:cd13138 233 PSALQQSLV--SISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIII 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 338 WLVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAP 417
Cdd:cd13138 311 SLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIP 390
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 186499234 418 VGIYLAFSCELNGKGLWCGVVVGSAVQAIILAIVTASMNWK 458
Cdd:cd13138 391 LAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
258-419 |
3.74e-19 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 84.15 E-value: 3.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 258 PSAAMLCLEWWLFELLILCSGLLqnPKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCL 337
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 338 WLVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAyYLVGAP 417
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
|
..
gi 186499234 418 VG 419
Cdd:pfam01554 158 LN 159
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-458 |
1.56e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 87.56 E-value: 1.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 33 RLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVsgFSIMFGLVGSLET-LSGQAYGAKQYEKMGTYTYS 111
Cdd:cd13134 7 ALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL--LILIFSFISTGTSiLIAQYLGAKDKKKARQIAGV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 112 AISSNIPICVLIS-ILWIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTTLLF 190
Cdd:cd13134 85 ALLFNLLLGLVFSlLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNIL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 191 HIAVCWTLV----SALGLGSNGAALAISVSfWFFAMTLSCYVRFSSsceKTRRFVSQDFL----SSVKQFFRYGVPSAA- 261
Cdd:cd13134 165 NIVGNYLLIfgwfGLPKLGVAGVAISTVIS-RAVGLVLLFILLFRK---LKIRFRLKDLRpfpkKLLKKILKIGLPSAGe 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 262 MLCleWWLFELLILcSGLLQNPKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVE 341
Cdd:cd13134 241 ELS--YNLSQTVIT-AFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 342 SSFFSILLFAFRNIIGYAFSNSKEVVDYvadLSPLLCLSFVLD---GFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPV 418
Cdd:cd13134 318 SLAVALLLALFREPILGLFTDDPEIIAL---GKTLLLISILLEpgrAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPL 394
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 186499234 419 GIYLAFSCELNGKGLWCGVVVGSAVQAIILAIVTASMNWK 458
Cdd:cd13134 395 AYLLGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKWI 434
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
33-392 |
8.84e-15 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 76.01 E-value: 8.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 33 RLAVPMATVTIAQYLLPVISVMVAGH-NGELQLSGVALATSFTN-VSGFSIMFGLVGSleTLSGQAYGAKQYEKMGTYTY 110
Cdd:cd13143 8 KFALPAIIGMLVNGLYNIVDGIFVGHgVGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKANRIFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 111 SAISSNIPICVLISIL-WIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTTLL 189
Cdd:cd13143 86 TALLLSLILGLLLTILgLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 190 FHIAVCWTLVSALGLGSNGAALAISVSFWF-FAMTLSCYVRFSSSCEKTRRFVSQDFlSSVKQFFRYGVPSAAMLCLeww 268
Cdd:cd13143 166 LNIILDPLFIFVLGLGIAGAALATVIAQLIsLLLLLLYFFRGKSLLKLSLLRFKLSL-KIIKEILALGFPSFLMQLS--- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 269 LFELLILCSGLLQNPKLETSV--LSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFS 346
Cdd:cd13143 242 SSVVTIVLNLTLLGYGGDIGVaaFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 186499234 347 ILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNG 392
Cdd:cd13143 322 LILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSG 367
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
29-450 |
1.63e-14 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 75.29 E-value: 1.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 29 KKVSRLAVPMATVTIAQYLLPVISVMVAGHNGEL-QLSGVALATSFTNVSGFSIMFGLVGSlETLSGQAYGAKQYEKMGT 107
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTLFWLFGFLRMGT-TGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 108 YTYSA--ISSNIPICVLISILWIyMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFAL 185
Cdd:cd13136 82 LLVRAllLALAIGLLLILLQSPL-LALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 186 TTLLFHIAVCWTLVSALGLGSNGAALAISVSFW----FFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVK----QFFRygv 257
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYlgalLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKlnrdIFIR--- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 258 psaaMLCLewwlfeLLILCSGLLQNPKLETSVLS---ICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARvSVLAG 334
Cdd:cd13136 238 ----TLAL------LAAFLFFTALAARLGDVILAanqILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAAR-RVARR 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 335 LCLW-LVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWqhIGALNNVVAYYL 413
Cdd:cd13136 307 LLQWgLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATD--TRYLRNSMLVSL 384
|
410 420 430
....*....|....*....|....*....|....*..
gi 186499234 414 VGAPVGIYLAFSCELNGkGLWCGVVVGSAVQAIILAI 450
Cdd:cd13136 385 AVFLPLLFLLVPLWGNH-GLWLALILFMLLRGLTLAL 420
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
26-458 |
3.65e-14 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 74.40 E-value: 3.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 26 VELKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVAL-ATSFTNVSGFSImfGLVGSLETLSGQAYGAKQYEK 104
Cdd:PRK00187 7 TELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLgAASYSFVSIFCV--GVIAAVGTLVAIRHGAGDIEG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 105 MGTYTYSAISSNIPICVLISILWIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYF- 183
Cdd:PRK00187 85 ATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVIs 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 184 ---ALTTLLFHIAVC--WTLVSALGLGSNGAALAIsVSFwFFAMTLSCYVRFSSSCE--KTRRFVSQDFLSSVKQFFRYG 256
Cdd:PRK00187 165 lagAVANLLLNYALIegWFGLPKLGLMGIGLVTAL-VSN-GMALALALYIRRHPAYAayPLRKGLSRPSRAALRELWRLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 257 VPSAAMLCLEWWLFELLILCSGLLQNPKLETSvlSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLC 336
Cdd:PRK00187 243 LPIGGTYAVEVGLFTFAALCMGALGSTQLAAH--QIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 337 LWLVESSFFSILLFAFRNIIGYAFSN-----SKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAY 411
Cdd:PRK00187 321 FGAVVMLLFAGLFWLLPEAIIGLFLDrndpaFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACY 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 186499234 412 YLVGAPVGIYLAFSCELNGKGLWCGVVVGSAVQAIILaivTASMNWK 458
Cdd:PRK00187 401 WLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVAL---TLAFEWK 444
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
79-459 |
2.80e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 71.45 E-value: 2.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 79 FSIMFGLVGSLETLSGQAYGAKQYEKMGTYTYSAISSNIPICVLISILWIYMEK--LLISLGQDPDISRVAGSYaLRLI- 155
Cdd:cd13142 60 ISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSFVIILSLILAVLGYILSRplLLLLIGAPEEVYPLALAY-LRIIf 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 156 ---PTLFAHAIVLPLTRfllAQG-LVLPLLYFALTTLL------FHIAVcWTLVSALGLGsnGAALA--IS---VSFWFF 220
Cdd:cd13142 139 lglPFMFIFFVFNSLLR---GIGdTKTPMKIMFGSVLLnvildpLLIFG-IGPFPGLGVA--GAALAtvISrgiAAVIGL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 221 AMTLSCYVRFSSSCEKTRrfvsQDFlSSVKQFFRYGVPSAAMLCLEwwLFELLILCSGLLQNPKLETSVLSICLTTATLH 300
Cdd:cd13142 213 YLLFKGRVGLKISLRDLK----PDW-EWLKKIFRIGLPSSIEQSAR--ALGFTVMTALVAGFGTVVVAAYGIGNRIISLV 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 301 YVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLS 380
Cdd:cd13142 286 FLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPS 365
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186499234 381 FVLDGFTAVLNGVARGCGWQHIGALNNVVAYYLVGAPVGIYLAFSCELNGKGLWCGVVVGSAVQAIILAIVTASMNWKE 459
Cdd:cd13142 366 FPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
29-369 |
6.26e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 57.69 E-value: 6.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 29 KKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNvSGFSIMFGLVGSLETLSGQAYGAKQYEKMGTY 108
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFN-TITGFLGSISIGFTILGSQSVGAKDIKRINDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 109 TYSAISSNIPICVLISILWIYM-EKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTT 187
Cdd:cd13135 80 AISSIVYNSIIGVILFLLWLFGaRIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 188 LLFHIAVCWTLV-SALG---LGSNGAALAISVSFWFFAMTLSCYVR------FSSSCEKTRRFVSQDFLSSVKqffrYGV 257
Cdd:cd13135 160 NLLNVILDYVLIfGNFGfprLGIIGAAIATTIANVLNLIILVYLCRkikkltFKLSNTKVLKANIRPYKFTIK----LGL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 258 PSAAMLCLewWLFELLILCSGLLQNPKLETSVLSICLTTATLHYVIPVGVAAAVSTRVSNKLGAGIPQVARVSVLAGLCL 337
Cdd:cd13135 236 PLGGEEFL--WNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGL 313
|
330 340 350
....*....|....*....|....*....|..
gi 186499234 338 WLVESSFFSILLFAFRNIIGYAFSNSKEVVDY 369
Cdd:cd13135 314 GLLIYIAAAIVFLAFPYKILSLFTNDPELINY 345
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-458 |
2.13e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 56.08 E-value: 2.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 34 LAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSgFSIMFGLVGSLETLSGQAYGAKQYEKMGTYTYSAI 113
Cdd:cd13139 19 LAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 114 SSNIPICVLISIL-WIYMEKLLISLGQDPDISRVAGSYaLRLIptlFAHAIVLPLtRFLLA---QGLVLPLLyfALTTLL 189
Cdd:cd13139 98 LLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGY-TRIM---FGGNGFIML-LFLINgifRGAGDAAI--AMRSLW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 190 ----FHIAVCWTLVSALG----LGSNGAALA------ISVSFWFFAM-TLSCYVRFSSSCEKTRRFVSQDFLS-SVKQFF 253
Cdd:cd13139 171 langLNIILDPLFIFGLGpipaMGVTGAAIAttigrsIGVLYQLYHLfKGKGRIQIRRRHLKLDWAIIKKIIKiAVGGIL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 254 RYGVPSAAmlclewWLFELLILCSglLQNPKLETSVLSICLTTATLhyvIPV-GVAAAVSTRVSNKLGAGIPQVARVSVL 332
Cdd:cd13139 251 QFLIASSS------WIFLVRIIAE--FGSTALAGYTIAIRIIMFAL---LPAwGLSNAAATLVGQNLGAGQPDRAEKSVW 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 333 AGLCLWLVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAVLNGVARGCGWQHIGALNNVVAYY 412
Cdd:cd13139 320 RAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFW 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 186499234 413 LVGAPVGIYLAFSCELNGKGLWCGVVVGSAVQAIILAIVTASMNWK 458
Cdd:cd13139 400 LFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWK 445
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
28-239 |
1.97e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 43.75 E-value: 1.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 28 LKKVSRLAVPmatvTIAQYLLPVIS----VMVAGHNGELQLSGVALATsftNVSGFSIM--FGLVGSLETLSGQAYGAKQ 101
Cdd:cd13139 238 IKKIIKIAVG----GILQFLIASSSwiflVRIIAEFGSTALAGYTIAI---RIIMFALLpaWGLSNAAATLVGQNLGAGQ 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 102 YEKMGTYTYSAISSNIPICVLISILWIYMEKLLISL-GQDPDISRVAgSYALRLIPT-LFAHAIVLPLTRFLLAQG-LVL 178
Cdd:cd13139 311 PDRAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFfTTDPEVIAIA-VEALRIISLgYIFYGYGMVLSQAFNGAGdTKT 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186499234 179 PLLYFALTTLLFHIAVCWTLVSALGLGSNGAALAISVSfwFFAMTLSCYVRFSSSCEKTRR 239
Cdd:cd13139 390 PTLINLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIA--ETVLAIAAIILFRRGKWKTVK 448
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
29-265 |
4.84e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 42.30 E-value: 4.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 29 KKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSgFSIMFGLVGSLETLSGQAYGAK-QYEKMGT 107
Cdd:cd13141 11 KHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFV-MALTQVLNVGTAALVSHAVGRKdQGEANAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 108 YTYSAISSNIPICVLISILWIYMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTT 187
Cdd:cd13141 90 FNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 188 LLFHIAVCWTLVSALG----LGSNGAALAISVSFwFFAMTLSCYVRFsssceKTRRFVSQDF------LSSVKQFFRYGV 257
Cdd:cd13141 170 VLLNIILAPILITGWGtgraLGVAGAGLASSISV-AIAVVLLLYYFL-----RLEKYLRLDLalwrpdLPTWKRLLKIGL 243
|
....*...
gi 186499234 258 PSAAMLCL 265
Cdd:cd13141 244 PSGGEFLL 251
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
32-230 |
5.51e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 42.39 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 32 SRLAVPMATVTIAQYLLPVISV--MVAGHNGELQLSGVALaTSFTNVSGFS-----IMFGLVGSLETLSGQAYGAKQYEK 104
Cdd:cd13146 228 SSVIVEILRVGLPQMLLQLISSisFLIYNRIIIDIDPVAM-TAFTLVGRLDqfiliPIFAISSALLTIAGQNWGRGNYDR 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 105 MGTYTYSAISSNIPICVLISILWIYMEKLLISL-GQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYF 183
Cdd:cd13146 307 MLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLfTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLL 386
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 186499234 184 ALTTLLF-HIAVCWTLVSALGLGSNGAALAIsVSFWFFAMTLSCYVRF 230
Cdd:cd13146 387 TLIRHVFlSVPVVYLLAYVFGKGITGVYFGI-VSANFFTALLAMFWGL 433
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
158-273 |
8.85e-04 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 41.67 E-value: 8.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 158 LFAHAIVLPLTRFLLAQGLVLPLLYFALTTLLFHIAVCWTLVSALGLGsnGAALAISVSFWFFAMTLSCYVRfssscekt 237
Cdd:COG0728 356 LPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHA--GLALATSLSALVNALLLLVLLR-------- 425
|
90 100 110
....*....|....*....|....*....|....*.
gi 186499234 238 RRFVSQDFLSSVKQFFRYGVPSAAMLCLEWWLFELL 273
Cdd:COG0728 426 RRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLL 461
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
27-163 |
1.56e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 40.74 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 27 ELKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVsGFSIMFGLVGSLETLSGQAYGAKQYEKMG 106
Cdd:cd13135 226 PYKFTIKLGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENI-VLMPMYGYSSAALTLVGESIGKKDLKEAL 304
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 186499234 107 TYTYSAISSNIPICVLISILWIYMEKLLISL-GQDPDISRVAGSYALRLIPTLFAHAI 163
Cdd:cd13135 305 RIGNICLGLGLLIYIAAAIVFLAFPYKILSLfTNDPELINYSIPYLIFIIIILFFKSI 362
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
79-450 |
2.32e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 40.08 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 79 FSIMFGLVGSLETLSGQAYGAKQYEKMGTYTYSAISSNIPICVLIS-ILWIYMEKLLISLGQDPDISRVAGSYALRLIPT 157
Cdd:cd13146 60 LALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVvLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 158 LFAHAIVLPLTRFLLAQGLVLPLLYFALTTLLFHIAVCWTLVSALGLGSNGAALAISVSFwFFAMTLSCYVRFSSSCEKT 237
Cdd:cd13146 140 VPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQ-AISLLYLLYVFLIGKSNVT 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 238 RRFVSQDFLSSV-KQFFRYGVPSAamlclewwLFELLILCSGLLQNpKLETSVLSICLTTATLH------YVIPV-GVAA 309
Cdd:cd13146 219 IHIKLSNISSSViVEILRVGLPQM--------LLQLISSISFLIYN-RIIIDIDPVAMTAFTLVgrldqfILIPIfAISS 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 310 AVSTRVSNKLGAGIPQVARVSVLAGLCLWLVESSFFSILLFAFRNIIGYAFSNSKEVVDYVADLSPLLCLSFVLDGFTAV 389
Cdd:cd13146 290 ALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISIL 369
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186499234 390 LNGVARGCGWQHIGALNNVVAYYLVGAPVGIYLAFSCELNGKGLWCGVVVGSAVQAIILAI 450
Cdd:cd13146 370 VTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTALLAMF 430
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
84-230 |
3.40e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 39.89 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 84 GLVGSLETLSGQAYGAKQYEKMGTYTYSAISSNIPICVLISILWIYMEKLLISL-GQDPDISRVAGSYaLRlIPTLFAHA 162
Cdd:cd13145 288 GLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLfTNDPAVIAIGAGY-LR-IDALIFYA 365
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186499234 163 IVLPLTRFLLAQGLVLPLLYFALT---TLLFHIAVCWTLVSALGLGSNGAALAISVSFWFFAMTLSCYVRF 230
Cdd:cd13145 366 YVVLFISVSVLQGLKRPIFALWIGlyrQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-265 |
4.98e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 39.14 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 33 RLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSgFSIMFGLVGSLETLSGQAYGAKQYEKmgtyTYSA 112
Cdd:cd13144 12 TMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKE----ANKA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 113 ISSNIPICVLISILWI-----YMEKLLISLGQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFALTT 187
Cdd:cd13144 87 ANNGLLLALLSYLLFLllglfGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 188 LLFHIAV----CWTLVSALGLGSNGAALAiSVSFWFFAMTLSCYVRFSSSCE---KTRRFvsQDFLSSVKQFFRYGVPSA 260
Cdd:cd13144 167 AIINIILdpilIFGLFGFPAMGIAGAAIA-TVIGQILAMFLAFFFLLRKNKDvqpDLRLF--RPSLRIIKEIYAVGLPSI 243
|
....*
gi 186499234 261 AMLCL 265
Cdd:cd13144 244 IMQAI 248
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
28-356 |
5.36e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 39.05 E-value: 5.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 28 LKKVSRLAVPMATVTIAQYLLPVISVMVAGHNGELQLSGVALATSFTNVSGFSIMFGLVGSlETLSGQAYGAKQYEKMGT 107
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGFFVWLAYALALLSKIGA-QVKVSQSIGAKDEKEARK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 108 YTYSAISSNIPICVLISILWIYMEKLLISL--GQDPDISRVAGSYALRLIPTLFAHAIVLPLTRFLLAQGLVLPLLYFAL 185
Cdd:cd13140 83 YARNALQLNLLLGILYGLLLLLFAKPLIGFfnLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 186 TTLLFHIAVCWTLVSALG----LGSNGAALAISVSFWFFAMTLSCYVRFSSSCEKTRRFVSQDFLSSVKQFFRYGVPSAA 261
Cdd:cd13140 163 IGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLPVAL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186499234 262 MLCLeWWLFELLI--LCSGLLQNP----KLETSVLSICLTTATlhyvipvGVAAAVSTRVSNKLGAGIPQVARVSVLAGL 335
Cdd:cd13140 243 QSIL-FALISMILarIIASFGPVAiaaqKVGSQIESISWMTAE-------GFSTALAAFVGQNYGAGKYDRIRKGYKTAL 314
|
330 340
....*....|....*....|.
gi 186499234 336 CLWLVESSFFSILLFAFRNII 356
Cdd:cd13140 315 KIASAIGLFATLLLFFFGEPL 335
|
|
| |
