NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15227302|ref|NP_179277|]
View 

plasma membrane intrinsic protein 2;8 [Arabidopsis thaliana]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 28-257 1.96e-95

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 279.97  E-value: 1.96e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302    28 ELKLWSFYRAIIAEFIATLLFLYVTVATVIGHKNQTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFL 107
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   108 ARKVSLPRAVAYMVAQCLGAICGVGLVKAFMMtPYKRLGGGANTVADGYSTGTALGAEIIGTFVLVYTVFSATDPKRSAR 187
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTV-GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   188 DSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNekaWDDHWIFWVGPFVGALAAAAYH 257
Cdd:pfam00230 160 LGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 28-257 1.96e-95

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 279.97  E-value: 1.96e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302    28 ELKLWSFYRAIIAEFIATLLFLYVTVATVIGHKNQTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFL 107
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   108 ARKVSLPRAVAYMVAQCLGAICGVGLVKAFMMtPYKRLGGGANTVADGYSTGTALGAEIIGTFVLVYTVFSATDPKRSAR 187
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTV-GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   188 DSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNekaWDDHWIFWVGPFVGALAAAAYH 257
Cdd:pfam00230 160 LGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-260 2.06e-78

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 237.15  E-value: 2.06e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  36 RAIIAEFIATLLFLYVTVATVIGHKNQTGpcGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPR 115
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG--ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302 116 AVAYMVAQCLGAICGVGLVKAFMMTPYKRLGGGANTVAD--------GYSTGTALGAEIIGTFVLVYTVFSATDPKRSAr 187
Cdd:cd00333  79 VIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGifgtypspGVSNGNAFFVEFIGTFILVLVVFATTDDPNGP- 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227302 188 dsHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWDDHWIFWVGPFVGALAAAAYHQYI 260
Cdd:cd00333 158 --PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-257 1.15e-65

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 204.07  E-value: 1.15e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302    40 AEFIATLLFLYVTVATVIG--HKNQTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPRAV 117
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   118 AYMVAQCLGAICGVGLVKAFMMTPYKRLGGGANTVADGYSTGTALGAEIIGTFVLVYTVFSATDpKRSARDSHvpVLAPL 197
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRG--GFAPL 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   198 PIGFAVFMVHLATIPITGTGINPARSFGAAVIyNNEKAWDDHWIFWVGPFVGALAAAAYH 257
Cdd:TIGR00861 158 AIGLLVFLIHLSMGPYTGTGMNPARSLGPALF-AGLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 33-262 2.85e-59

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 188.41  E-value: 2.85e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  33 SFYRAIIAEFIAT--LLFLYVTVATVIghknqTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARK 110
Cdd:COG0580   1 SLMKRLLAEFLGTfiLVLLGCGVVAVL-----AGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302 111 VSLPRAVAYMVAQCLGAICGVGLVKAFMMTPYKRLGGGANTV-------ADGYSTGTALGAEIIGTFVLVYTVFSATDPK 183
Cdd:COG0580  76 FPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKR 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302 184 RSARdshvpVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEK---AWDDHWIFWVGPFVGALAAAAYHQYI 260
Cdd:COG0580 156 AAPG-----GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsDWGYLWVPIVAPILGAALAALLYRAL 230


                ..
gi 15227302 261 LR 262
Cdd:COG0580 231 FG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 36-256 8.57e-36

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 128.37  E-value: 8.57e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   36 RAIIAEFIATLLFLYVTVATVIGHKNQT--GPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSL 113
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKLTdnGSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  114 PRAVAYMVAQCLGAICGVGLVKafMMTpykrlgGGANTVADGYSTGT----ALGAEIIGTFVLVYTVF-SATDPKRsard 188
Cdd:PLN00027 101 LRGILYWIAQLLGSVVACLLLK--FST------GGLETSAFSLSSGVgvwnAFVFEIVMTFGLVYTVYaTAVDPKK---- 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227302  189 SHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNekaWDDHWIFWVGPFVG-ALAAAAY 256
Cdd:PLN00027 169 GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWT---WTNHWVYWAGPLIGgGIAGLVY 234
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 28-257 1.96e-95

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 279.97  E-value: 1.96e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302    28 ELKLWSFYRAIIAEFIATLLFLYVTVATVIGHKNQTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFL 107
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   108 ARKVSLPRAVAYMVAQCLGAICGVGLVKAFMMtPYKRLGGGANTVADGYSTGTALGAEIIGTFVLVYTVFSATDPKRSAR 187
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTV-GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   188 DSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNekaWDDHWIFWVGPFVGALAAAAYH 257
Cdd:pfam00230 160 LGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-260 2.06e-78

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 237.15  E-value: 2.06e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  36 RAIIAEFIATLLFLYVTVATVIGHKNQTGpcGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPR 115
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG--ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302 116 AVAYMVAQCLGAICGVGLVKAFMMTPYKRLGGGANTVAD--------GYSTGTALGAEIIGTFVLVYTVFSATDPKRSAr 187
Cdd:cd00333  79 VIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGifgtypspGVSNGNAFFVEFIGTFILVLVVFATTDDPNGP- 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227302 188 dsHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWDDHWIFWVGPFVGALAAAAYHQYI 260
Cdd:cd00333 158 --PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-257 1.15e-65

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 204.07  E-value: 1.15e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302    40 AEFIATLLFLYVTVATVIG--HKNQTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPRAV 117
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   118 AYMVAQCLGAICGVGLVKAFMMTPYKRLGGGANTVADGYSTGTALGAEIIGTFVLVYTVFSATDpKRSARDSHvpVLAPL 197
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRG--GFAPL 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   198 PIGFAVFMVHLATIPITGTGINPARSFGAAVIyNNEKAWDDHWIFWVGPFVGALAAAAYH 257
Cdd:TIGR00861 158 AIGLLVFLIHLSMGPYTGTGMNPARSLGPALF-AGLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 33-262 2.85e-59

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 188.41  E-value: 2.85e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  33 SFYRAIIAEFIAT--LLFLYVTVATVIghknqTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARK 110
Cdd:COG0580   1 SLMKRLLAEFLGTfiLVLLGCGVVAVL-----AGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGR 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302 111 VSLPRAVAYMVAQCLGAICGVGLVKAFMMTPYKRLGGGANTV-------ADGYSTGTALGAEIIGTFVLVYTVFSATDPK 183
Cdd:COG0580  76 FPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKR 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302 184 RSARdshvpVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEK---AWDDHWIFWVGPFVGALAAAAYHQYI 260
Cdd:COG0580 156 AAPG-----GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsDWGYLWVPIVAPILGAALAALLYRAL 230


                ..
gi 15227302 261 LR 262
Cdd:COG0580 231 FG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 36-256 8.57e-36

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 128.37  E-value: 8.57e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   36 RAIIAEFIATLLFLYVTVATVIGHKNQT--GPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSL 113
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKLTdnGSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  114 PRAVAYMVAQCLGAICGVGLVKafMMTpykrlgGGANTVADGYSTGT----ALGAEIIGTFVLVYTVF-SATDPKRsard 188
Cdd:PLN00027 101 LRGILYWIAQLLGSVVACLLLK--FST------GGLETSAFSLSSGVgvwnAFVFEIVMTFGLVYTVYaTAVDPKK---- 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227302  189 SHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNekaWDDHWIFWVGPFVG-ALAAAAY 256
Cdd:PLN00027 169 GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWT---WTNHWVYWAGPLIGgGIAGLVY 234
PLN00166 PLN00166
aquaporin TIP2; Provisional
 36-256 2.94e-34

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 124.28  E-value: 2.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   36 RAIIAEFIATLLFLYVTVATVIGHKNQT--GPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSL 113
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKLTsdAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  114 PRAVAYMVAQCLGAICGVGLVKafMMTPYKRLggGANTVADGYSTGTALGAEIIGTFVLVYTVF-SATDPKRSArdshVP 192
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLV--FVTNGESV--PTHGVAAGLGAIEGVVMEIVVTFALVYTVYaTAADPKKGS----LG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227302  193 VLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNekaWDDHWIFWVGPFV-GALAAAAY 256
Cdd:PLN00166 171 TIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGD---FSQIWIYWVGPLVgGALAGLIY 232
PRK05420 PRK05420
aquaporin Z; Provisional
 68-261 7.57e-32

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 117.38  E-value: 7.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   68 GVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPRAVAYMVAQCLGAICGVGL--VKAFMMTPYKRL 145
Cdd:PRK05420  33 GIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVPYIIAQVVGGIAAAAVlyLIASGKAGFDLA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  146 GGG--ANTVAD----GYSTGTALGAEIIGTFVLVYTVFSATdpkrsarDSHVPV-LAPLPIGFAVFMVHLATIPITGTGI 218
Cdd:PRK05420 113 GSGfaSNGYGEhspgGYSLLAALVCEVVLTAFFLLVILGAT-------DKRAPAgFAPIAIGLALTLIHLISIPVTNTSV 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 15227302  219 NPARSFGAAVIYNNEkAWDDHWIFWVGPFVGALAAAAYHQYIL 261
Cdd:PRK05420 186 NPARSTGVALFVGGW-ALEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 36-254 1.71e-27

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 106.91  E-value: 1.71e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   36 RAIIAEFIATLLFLYVTVATVIGHKN--QTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSL 113
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSRKlmPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  114 PRAVAYMVAQCLGAICGVGLVKAFMMTPYKRLgggaNTVADGYSTGTALGAEIIGTFVLVYTVFSATDPKRSARDShvpv 193
Cdd:PLN00167 103 PTAMFYWISQMLASVMACLFLKVTTVGQHVPT----YKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRGLLGA---- 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227302  194 LAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKawdDHWIFWVGPFVGALAAA 254
Cdd:PLN00167 175 IGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFK---NQAVYWVGPLLGGAVAG 232
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 1-261 4.27e-22

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 92.88  E-value: 4.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302    1 MSKEVSEEGRHgkdyvDPPPAPLLDMAELKLWsfYRAIIAEFIATLLFLYV---TVATVIGHKNQtgpcGGVGLLGIAWA 77
Cdd:PTZ00016  23 MDEEVAEAQKR-----PPGGQNFWAPREYRPN--VREYVAEFLGTFVLLFFgegVVATTHTVGNN----GDYLAITIGWG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   78 FGgmIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPRAVAYMVAQCLGAICGV----GLVKAFMMTPYKRL---GGGAN 150
Cdd:PTZ00016  92 LG--VTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAacvyGLYYGFFKDHGIPElpwETMAN 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  151 TVADGYSTGTALGA------EIIGTFVLVYTVFSATDPKRSARDSHVPVlaplPIGFAVFMVHLATIPITGTGINPARSF 224
Cdd:PTZ00016 170 GFAGVFATYPREGNfyaifsELILTAILLLVILAITDPNNCPAFNYLPV----AVGLLVFVIGISFGGNTGYALNPARDL 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 15227302  225 GA----AVIYNNEKAWDDHWIFW---VGPFVGALAAAAYHQYIL 261
Cdd:PTZ00016 246 GPrlfsAILWGSEVFTKDNYYFWvplVAPFVGAVLGMFLYDKFI 289
PLN00026 PLN00026
aquaporin NIP; Provisional
 1-255 6.20e-22

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 92.62  E-value: 6.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302    1 MSKEVSEEGRHGKDYVDPPPAPLldmaelklwSFYRAIIAEFIATLLFLYVTVATVIGHKNQTGpcgGVGLLGIAWAFGG 80
Cdd:PLN00026  46 FPVEALEWGRLPTCFCDLPPPDV---------SLTRKLGAEFVGTFILIFAATAGPIVNQKYDG---AETLIGNAACAGL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   81 MIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPRAVAYMVAQCLGAICGVGLVKAfMMTPYkrLGGGAnTVADGySTGT 160
Cdd:PLN00026 114 AVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYIAAQVSASICASFALKG-VFHPF--MSGGV-TVPSV-STGQ 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  161 ALGAEIIGTFVLVYTVFS-ATDPKRsardshVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWddh 239
Cdd:PLN00026 189 AFALEFIITFNLLFVVTAvATDTRA------VGELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAI--- 259

                        250
                 ....*....|....*.
gi 15227302  240 WIFWVGPFVGALAAAA 255
Cdd:PLN00026 260 WIYLVAPTLGALAGAG 275
PLN00184 PLN00184
aquaporin NIP1; Provisional
 3-254 1.93e-21

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 91.24  E-value: 1.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302    3 KEVSEEGRHGKDYVDPPPAPLLDMAELKLWSFYRAIIAEFIATLLFLYVTVATVIGHKNQTGpcgGVGLLGIAWAFGGMI 82
Cdd:PLN00184  22 KEEVEHQQEMEAIHNPKPLKKQDSLLSVSVPFLQKLIAEVLGTYFLVFTGCASVVVNMQNDN---VVTLPGIAIVWGLTI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   83 FVLVYCTAGISGGHINPAVTFGLFLARKVSLPRAVAYMVAQCLGAICGVGLVKAFMMTPYKRLGGGANTVADGYSTGTAL 162
Cdd:PLN00184  99 MVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVFIGSSPVGSDL 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  163 GA---EIIGTFVLVYTVFSATDPKRSardshVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWddh 239
Cdd:PLN00184 179 QAfvmEFIVTFYLMFIISGVATDNRA-----IGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGI--- 250

                        250
                 ....*....|....*
gi 15227302  240 WIFWVGPFVGALAAA 254
Cdd:PLN00184 251 WIYIVAPTLGAIAGA 265
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 38-260 3.80e-20

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 87.66  E-value: 3.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   38 IIAEFIATLLFLYVTVATVIGHkNQTGpcGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPRAV 117
Cdd:PLN00182  45 LIAEMIGTYFIIFSGCGVVVVN-VLYG--GTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVP 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  118 AYMVAQCLGAICGVGLVK-AFMMTPYKRLGggaNTVADgySTGTALGAEIIGTFVLVYTVFSATDPKRSARDshvpvLAP 196
Cdd:PLN00182 122 LYIGAQLTGSLLASLTLRlMFNVTPEAFFG---TTPTD--SSGQALVAEIIISFLLMFVISGVATDSRAVGE-----LAG 191

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227302  197 LPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWddhWIFWVGPFVGALAAAAYHQYI 260
Cdd:PLN00182 192 IAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGI---WVYIVGPFVGIIAGGFVYNLI 252
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 36-262 3.83e-19

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 84.52  E-value: 3.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302   36 RAIIAEFIATLLFLYvTVATVIGHKNQTGpcGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVT-----FGLFLARK 110
Cdd:PLN00183  46 RMVLAEMVGTFILMF-CVCGIIASTQLSG--GEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTiafatFGHFPWSK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  111 VSLpravaYMVAQCLGAICG--VGL----VKAFMMTPYKRLGggantvadgysTGTALGAEIIGTFVLVYTVFSATDPKR 184
Cdd:PLN00183 123 VPL-----YITAQTVGSVLAtyVGVsvygVKADLMTTKPAQG-----------CSSAFWVEFIATFIVMFLAASLTSQPQ 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227302  185 SARDshvpvLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIynnekAWD--DHWIFWVGPFVGALAAA-AYHQYIL 261
Cdd:PLN00183 187 SLGH-----LSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIV-----SWDfkDIWIYITAPTIGAVAGAlMFHLLRL 256


                 .
gi 15227302  262 R 262
Cdd:PLN00183 257 R 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH