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Conserved domains on  [gi|79557515|ref|NP_179287|]
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transportin 1 [Arabidopsis thaliana]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
16-730 1.13e-17

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 88.07  E-value: 1.13e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515  16 AEICSLLEQQI-SPSSVVDKSQiWKQLQHFSQfPDFNNYLVFIL-VRAEGKSV-EVRQAAGLLLKNNLRGAYP------- 85
Cdd:COG5215   4 SEFRCLGKNHVlSPDPNARLRA-EAQLLELQS-GDFEQFISLLVqVLCDLNSNdQLRMVAGLILKNSLHANDPelqkgcs 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515  86 ----SMTQENQKYIKSELLPCLGAADRNIRTTVGTIISVIVNIEGVSG-WHELLPALVTcldsndlnhMDGAMDALSKIC 160
Cdd:COG5215  82 qrwlGMRHESKEQVKGMALRALKSPEPRFCTMAAQLLAAIARMELPNSlWPGLMEEMVR---------NVGDEQPVSGKC 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 161 ED---IPHVLDTEVPGLAERPINIFLPRLLQFFQS--PHASLRKLALGsvnqyiiimpaviwqALYNSL----------- 224
Cdd:COG5215 153 ESlgiCGYHCESEAPEDLIQMSNVILFAIVMGALKneTTSAVRLAALK---------------ALMDSLmfvqgnfcyee 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 225 --DKYLQGLFVLANDPVPEVRKLVCAAFVHLTEVLPSSIEPHLRNVM-EYMLQVNRDPDEEVSLEACEFWSAYC------ 295
Cdd:COG5215 218 erNYFMQVVCEATQGNDEELQHAAFGCLNKIMMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICeeeidg 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 296 ---DAQLPPENLKEF------LPRLIPVLLenmayadddeSLLDAEEdesqPDRDQDlkprfhtsrlhgsedfdddddds 366
Cdd:COG5215 298 emeDKYLPEVPAQNHgfaraaVADVLPELL----------SLLEKQG----EDYYGD----------------------- 340

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 367 fnVWNLRKCSAAAIDVLSNVFGDEILPALMPLIQKNLSAsgdEAWKQREAAVLALGAIAEG-CMNGLYPHLSEIVAFLLP 445
Cdd:COG5215 341 --DWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRS---ESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIEN 415

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 446 LLDDKFPLIRSISCWTLSRFGKYLiQESGNPKGYEQFE--KVLMGLL---RRLLDTNKRVQEAACSaFATVEEDAAEELV 520
Cdd:COG5215 416 EMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHLVLEvsASLIGLMdcpFRSINCSWRKENLVDH-IAKAVREVESFLA 493

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 521 PHLGVILQHLMCAFG-KYQRRNLRI-VYDAIGTL----ADSVREELnkPAYLEILMPPL----VAKWQQLSNSDKDLF-P 589
Cdd:COG5215 494 KFYLAILNALVKGTElALNESNLRVsLFSALGTLilicPDAVSDIL--AGFYDYTSKKLdeciSVLGQILATEDQLLVeE 571

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 590 LLECFTSISQALGVGFAPFAQPVFQRCMDIIqLQQLAKVNPASAgaqYDREFIVcsldlLSGLAEGLGSGIESLVqqSNL 669
Cdd:COG5215 572 LQSNYIGVLEAIIRTRRRDIEDVEDQLMELF-IRILESTKPTTA---FGDVYTA-----ISALSTSLEERFEQYA--SKF 640

                       730       740       750       760       770       780
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79557515 670 RDLLLNCCIDEAADVRQSAFALMGDLARVFPVYLQPRLLDFLEIASQQLSANLNRENLSVA 730
Cdd:COG5215 641 IPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPA 701
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
16-730 1.13e-17

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 88.07  E-value: 1.13e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515  16 AEICSLLEQQI-SPSSVVDKSQiWKQLQHFSQfPDFNNYLVFIL-VRAEGKSV-EVRQAAGLLLKNNLRGAYP------- 85
Cdd:COG5215   4 SEFRCLGKNHVlSPDPNARLRA-EAQLLELQS-GDFEQFISLLVqVLCDLNSNdQLRMVAGLILKNSLHANDPelqkgcs 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515  86 ----SMTQENQKYIKSELLPCLGAADRNIRTTVGTIISVIVNIEGVSG-WHELLPALVTcldsndlnhMDGAMDALSKIC 160
Cdd:COG5215  82 qrwlGMRHESKEQVKGMALRALKSPEPRFCTMAAQLLAAIARMELPNSlWPGLMEEMVR---------NVGDEQPVSGKC 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 161 ED---IPHVLDTEVPGLAERPINIFLPRLLQFFQS--PHASLRKLALGsvnqyiiimpaviwqALYNSL----------- 224
Cdd:COG5215 153 ESlgiCGYHCESEAPEDLIQMSNVILFAIVMGALKneTTSAVRLAALK---------------ALMDSLmfvqgnfcyee 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 225 --DKYLQGLFVLANDPVPEVRKLVCAAFVHLTEVLPSSIEPHLRNVM-EYMLQVNRDPDEEVSLEACEFWSAYC------ 295
Cdd:COG5215 218 erNYFMQVVCEATQGNDEELQHAAFGCLNKIMMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICeeeidg 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 296 ---DAQLPPENLKEF------LPRLIPVLLenmayadddeSLLDAEEdesqPDRDQDlkprfhtsrlhgsedfdddddds 366
Cdd:COG5215 298 emeDKYLPEVPAQNHgfaraaVADVLPELL----------SLLEKQG----EDYYGD----------------------- 340

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 367 fnVWNLRKCSAAAIDVLSNVFGDEILPALMPLIQKNLSAsgdEAWKQREAAVLALGAIAEG-CMNGLYPHLSEIVAFLLP 445
Cdd:COG5215 341 --DWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRS---ESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIEN 415

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 446 LLDDKFPLIRSISCWTLSRFGKYLiQESGNPKGYEQFE--KVLMGLL---RRLLDTNKRVQEAACSaFATVEEDAAEELV 520
Cdd:COG5215 416 EMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHLVLEvsASLIGLMdcpFRSINCSWRKENLVDH-IAKAVREVESFLA 493

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 521 PHLGVILQHLMCAFG-KYQRRNLRI-VYDAIGTL----ADSVREELnkPAYLEILMPPL----VAKWQQLSNSDKDLF-P 589
Cdd:COG5215 494 KFYLAILNALVKGTElALNESNLRVsLFSALGTLilicPDAVSDIL--AGFYDYTSKKLdeciSVLGQILATEDQLLVeE 571

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 590 LLECFTSISQALGVGFAPFAQPVFQRCMDIIqLQQLAKVNPASAgaqYDREFIVcsldlLSGLAEGLGSGIESLVqqSNL 669
Cdd:COG5215 572 LQSNYIGVLEAIIRTRRRDIEDVEDQLMELF-IRILESTKPTTA---FGDVYTA-----ISALSTSLEERFEQYA--SKF 640

                       730       740       750       760       770       780
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79557515 670 RDLLLNCCIDEAADVRQSAFALMGDLARVFPVYLQPRLLDFLEIASQQLSANLNRENLSVA 730
Cdd:COG5215 641 IPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPA 701
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 411-465 1.72e-13

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 65.47  E-value: 1.72e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 79557515   411 WKQREAAVLALGAIAEGCMNGLYPHLSEIVAFLLPLLDDKFPLIRSISCWTLSRF 465
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 39-104 1.09e-07

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 49.55  E-value: 1.09e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79557515     39 KQLQHFSQFPDFNNYLVFILvrAEGKSVEVRQAAGLLLKNNLRGAYPSMTQENQKYIKSELLPCLG 104
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEIL--ANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLL 66
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
16-730 1.13e-17

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 88.07  E-value: 1.13e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515  16 AEICSLLEQQI-SPSSVVDKSQiWKQLQHFSQfPDFNNYLVFIL-VRAEGKSV-EVRQAAGLLLKNNLRGAYP------- 85
Cdd:COG5215   4 SEFRCLGKNHVlSPDPNARLRA-EAQLLELQS-GDFEQFISLLVqVLCDLNSNdQLRMVAGLILKNSLHANDPelqkgcs 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515  86 ----SMTQENQKYIKSELLPCLGAADRNIRTTVGTIISVIVNIEGVSG-WHELLPALVTcldsndlnhMDGAMDALSKIC 160
Cdd:COG5215  82 qrwlGMRHESKEQVKGMALRALKSPEPRFCTMAAQLLAAIARMELPNSlWPGLMEEMVR---------NVGDEQPVSGKC 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 161 ED---IPHVLDTEVPGLAERPINIFLPRLLQFFQS--PHASLRKLALGsvnqyiiimpaviwqALYNSL----------- 224
Cdd:COG5215 153 ESlgiCGYHCESEAPEDLIQMSNVILFAIVMGALKneTTSAVRLAALK---------------ALMDSLmfvqgnfcyee 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 225 --DKYLQGLFVLANDPVPEVRKLVCAAFVHLTEVLPSSIEPHLRNVM-EYMLQVNRDPDEEVSLEACEFWSAYC------ 295
Cdd:COG5215 218 erNYFMQVVCEATQGNDEELQHAAFGCLNKIMMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICeeeidg 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 296 ---DAQLPPENLKEF------LPRLIPVLLenmayadddeSLLDAEEdesqPDRDQDlkprfhtsrlhgsedfdddddds 366
Cdd:COG5215 298 emeDKYLPEVPAQNHgfaraaVADVLPELL----------SLLEKQG----EDYYGD----------------------- 340

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 367 fnVWNLRKCSAAAIDVLSNVFGDEILPALMPLIQKNLSAsgdEAWKQREAAVLALGAIAEG-CMNGLYPHLSEIVAFLLP 445
Cdd:COG5215 341 --DWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRS---ESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIEN 415

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 446 LLDDKFPLIRSISCWTLSRFGKYLiQESGNPKGYEQFE--KVLMGLL---RRLLDTNKRVQEAACSaFATVEEDAAEELV 520
Cdd:COG5215 416 EMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHLVLEvsASLIGLMdcpFRSINCSWRKENLVDH-IAKAVREVESFLA 493

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 521 PHLGVILQHLMCAFG-KYQRRNLRI-VYDAIGTL----ADSVREELnkPAYLEILMPPL----VAKWQQLSNSDKDLF-P 589
Cdd:COG5215 494 KFYLAILNALVKGTElALNESNLRVsLFSALGTLilicPDAVSDIL--AGFYDYTSKKLdeciSVLGQILATEDQLLVeE 571

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 590 LLECFTSISQALGVGFAPFAQPVFQRCMDIIqLQQLAKVNPASAgaqYDREFIVcsldlLSGLAEGLGSGIESLVqqSNL 669
Cdd:COG5215 572 LQSNYIGVLEAIIRTRRRDIEDVEDQLMELF-IRILESTKPTTA---FGDVYTA-----ISALSTSLEERFEQYA--SKF 640

                       730       740       750       760       770       780
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79557515 670 RDLLLNCCIDEAADVRQSAFALMGDLARVFPVYLQPRLLDFLEIASQQLSANLNRENLSVA 730
Cdd:COG5215 641 IPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPA 701
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 411-465 1.72e-13

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 65.47  E-value: 1.72e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 79557515   411 WKQREAAVLALGAIAEGCMNGLYPHLSEIVAFLLPLLDDKFPLIRSISCWTLSRF 465
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N pfam03810
Importin-beta N-terminal domain;
38-104 2.23e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 60.33  E-value: 2.23e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 79557515    38 WKQLQHFSQFPDFNNYLVFILVRAEgKSVEVRQAAGLLLKNNLR----GAYPSMTQENQKYIKSELLPCLG 104
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSE-NPLEVRQLAALYLKNLITrhweEEKNSLPPEEKEQIKNNLLNLLG 71
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 39-104 1.09e-07

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 49.55  E-value: 1.09e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79557515     39 KQLQHFSQFPDFNNYLVFILvrAEGKSVEVRQAAGLLLKNNLRGAYPSMTQENQKYIKSELLPCLG 104
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEIL--ANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLL 66
HEAT COG1413
HEAT repeat [General function prediction only];
377-523 5.26e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.93  E-value: 5.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 377 AAAIDVLSNVFGDEILPALMPLIQknlsasgDEAWKQREAAVLALGAIAEgcmnglyphlSEIVAFLLPLLDDKFPLIRS 456
Cdd:COG1413   3 RAAARALGRLGDPAAVPALIAALA-------DEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRA 65

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 79557515 457 ISCWTLSRFGkyliqesgnpkgYEQFEKVLMGLLRrllDTNKRVQEAACSAFATV-EEDAAEELVPHL 523
Cdd:COG1413  66 AAAEALGRIG------------DPEAVPALIAALK---DEDPEVRRAAAEALGRLgDPAAVPALLEAL 118
HEAT COG1413
HEAT repeat [General function prediction only];
377-507 1.56e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 377 AAAIDVLSNVFGDEILPALMPLIQknlsasgDEAWKQREAAVLALGAIAEgcmnglyphlSEIVAFLLPLLDDKFPLIRS 456
Cdd:COG1413  34 AAAARALGRLGDPRAVPALLEALK-------DPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDEDPEVRR 96

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 79557515 457 ISCWTLSRFGKyliqesgnpkgyeqfEKVLMGLLRRLLDTNKRVQEAACSA 507
Cdd:COG1413  97 AAAEALGRLGD---------------PAAVPALLEALKDPDWEVRRAAARA 132
HEAT COG1413
HEAT repeat [General function prediction only];
377-466 1.23e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515 377 AAAIDVLSNVFGDEILPALMPLIQknlsasgDEAWKQREAAVLALGAIAEgcmnglyphlSEIVAFLLPLLDDKFPLIRS 456
Cdd:COG1413  65 AAAAEALGRIGDPEAVPALIAALK-------DEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWEVRR 127

                        90
                ....*....|
gi 79557515 457 ISCWTLSRFG 466
Cdd:COG1413 128 AAARALGRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 395-509 4.57e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 4.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79557515   395 LMPLIQKnlsASGDEAWKQREAAVLALGAIAEgcmnglyphlSEIVAFLLPLLDDKFPLIRSISCWTLSRFgkyliqesG 474
Cdd:pfam13646   1 LPALLQA---LLRDPDPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKI--------G 59

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 79557515   475 NPKGYEqfekVLMGLLRRllDTNKRVQEAACSAFA 509
Cdd:pfam13646  60 DPEALP----ALLELLRD--DDDDVVRAAAAEALA 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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