F-box and associated interaction domains-containing protein [Arabidopsis thaliana]
Protein Classification
F-box protein( domain architecture ID 18135504)
F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation
List of domain hits
| Name | Accession | Description | Interval | E-value | |||
| FBA_1 | pfam07734 | F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ... |
208-363 | 6.42e-60 | |||
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination. : Pssm-ID: 254394 Cd Length: 159 Bit Score: 190.51 E-value: 6.42e-60
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| F-box_SF super family | cl45894 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
10-48 | 1.41e-08 | |||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. The actual alignment was detected with superfamily member cd22157: Pssm-ID: 459239 Cd Length: 39 Bit Score: 50.15 E-value: 1.41e-08
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| Name | Accession | Description | Interval | E-value | |||||
| FBA_1 | pfam07734 | F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ... |
208-363 | 6.42e-60 | |||||
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination. Pssm-ID: 254394 Cd Length: 159 Bit Score: 190.51 E-value: 6.42e-60
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| F_box_assoc_1 | TIGR01640 | F-box protein interaction domain; This model describes a large family of plant domains, with ... |
109-355 | 1.62e-43 | |||||
F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain. Pssm-ID: 273726 [Multi-domain] Cd Length: 230 Bit Score: 150.59 E-value: 1.62e-43
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| F-box_AtFBW1-like | cd22157 | F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ... |
10-48 | 1.41e-08 | |||||
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438928 Cd Length: 39 Bit Score: 50.15 E-value: 1.41e-08
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| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
9-51 | 1.18e-06 | |||||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 44.84 E-value: 1.18e-06
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
12-52 | 3.65e-06 | |||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 43.19 E-value: 3.65e-06
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| Name | Accession | Description | Interval | E-value | |||||
| FBA_1 | pfam07734 | F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ... |
208-363 | 6.42e-60 | |||||
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination. Pssm-ID: 254394 Cd Length: 159 Bit Score: 190.51 E-value: 6.42e-60
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| F_box_assoc_1 | TIGR01640 | F-box protein interaction domain; This model describes a large family of plant domains, with ... |
109-355 | 1.62e-43 | |||||
F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain. Pssm-ID: 273726 [Multi-domain] Cd Length: 230 Bit Score: 150.59 E-value: 1.62e-43
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| F-box_AtFBW1-like | cd22157 | F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ... |
10-48 | 1.41e-08 | |||||
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438928 Cd Length: 39 Bit Score: 50.15 E-value: 1.41e-08
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| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
9-51 | 1.18e-06 | |||||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 44.84 E-value: 1.18e-06
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
12-52 | 3.65e-06 | |||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 43.19 E-value: 3.65e-06
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| F-box_SF | cd09917 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
10-44 | 1.16e-03 | |||||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. Pssm-ID: 438852 Cd Length: 35 Bit Score: 36.27 E-value: 1.16e-03
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| F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
9-45 | 3.88e-03 | |||||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 34.77 E-value: 3.88e-03
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