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Conserved domains on  [gi|145360201|ref|NP_179796|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 30-74 2.42e-14

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 65.28  E-value: 2.42e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 145360201  30 SFTSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPELSRLR 74
Cdd:cd22152    1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
124-251 7.72e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.41  E-value: 7.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145360201 124 PIPFPSHHSMynSSAVGSEIYFVGG--SFEPMSELWILDTRTGMFRQGPSMKVARTDEASVGVINGKIYVIGGCEDKIQ- 200
Cdd:COG3055    8 DLPTPRSEAA--AALLDGKVYVAGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANPs 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145360201 201 ------VEVYDPKSRSWktTKDPEEKTQRGlmtRLSAVSLDWKVYTV-------EVGRIGVYDP 251
Cdd:COG3055   86 stplndVYVYDPATNTW--TKLAPMPTPRG---GATALLLDGKIYVVggwddggNVAWVEVYDP 144
 
Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 30-74 2.42e-14

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 65.28  E-value: 2.42e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 145360201  30 SFTSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPELSRLR 74
Cdd:cd22152    1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
124-251 7.72e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.41  E-value: 7.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145360201 124 PIPFPSHHSMynSSAVGSEIYFVGG--SFEPMSELWILDTRTGMFRQGPSMKVARTDEASVGVINGKIYVIGGCEDKIQ- 200
Cdd:COG3055    8 DLPTPRSEAA--AALLDGKVYVAGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANPs 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145360201 201 ------VEVYDPKSRSWktTKDPEEKTQRGlmtRLSAVSLDWKVYTV-------EVGRIGVYDP 251
Cdd:COG3055   86 stplndVYVYDPATNTW--TKLAPMPTPRG---GATALLLDGKIYVVggwddggNVAWVEVYDP 144
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 31-70 7.65e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.53  E-value: 7.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 145360201   31 FTSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPEL 70
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 180-212 2.87e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.37  E-value: 2.87e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145360201  180 ASVGVINGKIYVIGGCEDKIQ---VEVYDPKSRSWK 212
Cdd:pfam01344   5 AGVVVVGGKIYVIGGFDGNQSlnsVEVYDPETNTWS 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
34-70 4.01e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.81  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 145360201    34 LPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPEL 70
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDF 37
PHA03098 PHA03098
kelch-like protein; Provisional
 134-216 4.08e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 44.37  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145360201 134 YNSSAVGSEIYFVGG---SFEPMSELWILDTRTGMFRQGPSMKVARTDeASVGVINGKIYVIGGCEDKI---QVEVYDPK 207
Cdd:PHA03098 288 FGSVVLNNVIYFIGGmnkNNLSVNSVVSYDTKTKSWNKVPELIYPRKN-PGVTVFNNRIYVIGGIYNSIslnTVESWKPG 366


                 ....*....
gi 145360201 208 SRSWKTTKD 216
Cdd:PHA03098 367 ESKWREEPP 375
Kelch smart00612
Kelch domain;
143-187 1.70e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.31  E-value: 1.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 145360201   143 IYFVGGSF--EPMSELWILDTRTGMFRQGPSMKVARTDeASVGVING 187
Cdd:smart00612   2 IYVVGGFDggQRLKSVEVYDPETNKWTPLPSMPTPRSG-HGVAVING 47
 
Name Accession Description Interval E-value
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 30-74 2.42e-14

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 65.28  E-value: 2.42e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 145360201  30 SFTSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPELSRLR 74
Cdd:cd22152    1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
124-251 7.72e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.41  E-value: 7.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145360201 124 PIPFPSHHSMynSSAVGSEIYFVGG--SFEPMSELWILDTRTGMFRQGPSMKVARTDEASVGVINGKIYVIGGCEDKIQ- 200
Cdd:COG3055    8 DLPTPRSEAA--AALLDGKVYVAGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTGANPs 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145360201 201 ------VEVYDPKSRSWktTKDPEEKTQRGlmtRLSAVSLDWKVYTV-------EVGRIGVYDP 251
Cdd:COG3055   86 stplndVYVYDPATNTW--TKLAPMPTPRG---GATALLLDGKIYVVggwddggNVAWVEVYDP 144
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
126-205 8.54e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 54.78  E-value: 8.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145360201 126 PFPSHHSMYNSSAVGSEIYFVGGSFEPMSELWILDTRTGMFRQGPSMKVARTDEASVgVINGKIYVIGGC-------EDK 198
Cdd:COG3055  192 PLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAAV-LTDGKVYVIGGEtkpgvrtPLV 270


                 ....*..
gi 145360201 199 IQVEVYD 205
Cdd:COG3055  271 TSAEVYD 277
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 31-70 7.65e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 47.53  E-value: 7.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 145360201   31 FTSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPEL 70
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
124-241 4.56e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 49.77  E-value: 4.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145360201 124 PIPFP-SHHSMYnssAVGSEIYFVGG--SFEPMSELWILDTRTGMFRQGPSMKVARTDEASVGVINGKIYVIGGCEDKI- 199
Cdd:COG3055  107 PMPTPrGGATAL---LLDGKIYVVGGwdDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDGKILVIGGRNGSGf 183

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145360201 200 -------------------------------------QVEVYDPKSRSWKTTkdPEEKTQRglmTRLSAVSLDWKVYTV 241
Cdd:COG3055  184 sntwttlaplptaraghaaavlggkilvfggesgfsdEVEAYDPATNTWTAL--GELPTPR---HGHAAVLTDGKVYVI 257
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 180-212 2.87e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.37  E-value: 2.87e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145360201  180 ASVGVINGKIYVIGGCEDKIQ---VEVYDPKSRSWK 212
Cdd:pfam01344   5 AGVVVVGGKIYVIGGFDGNQSlnsVEVYDPETNTWS 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
34-70 4.01e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.81  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 145360201    34 LPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPEL 70
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDF 37
PHA03098 PHA03098
kelch-like protein; Provisional
 134-216 4.08e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 44.37  E-value: 4.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145360201 134 YNSSAVGSEIYFVGG---SFEPMSELWILDTRTGMFRQGPSMKVARTDeASVGVINGKIYVIGGCEDKI---QVEVYDPK 207
Cdd:PHA03098 288 FGSVVLNNVIYFIGGmnkNNLSVNSVVSYDTKTKSWNKVPELIYPRKN-PGVTVFNNRIYVIGGIYNSIslnTVESWKPG 366


                 ....*....
gi 145360201 208 SRSWKTTKD 216
Cdd:PHA03098 367 ESKWREEPP 375
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 30-72 6.98e-05

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 39.52  E-value: 6.98e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 145360201  30 SFTSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVrSPELSR 72
Cdd:cd22143    1 AFDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLA-LPELWR 42
Kelch smart00612
Kelch domain;
143-187 1.70e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.31  E-value: 1.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 145360201   143 IYFVGGSF--EPMSELWILDTRTGMFRQGPSMKVARTDeASVGVING 187
Cdd:smart00612   2 IYVVGGFDggQRLKSVEVYDPETNKWTPLPSMPTPRSG-HGVAVING 47
PHA03098 PHA03098
kelch-like protein; Provisional
 128-217 2.40e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 42.06  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145360201 128 PSHHSMYNSSAV--GSEIYFVGG-----SFEPMSELWILDTRTGMFRQGPSMKVARTDeASVGVINGKIYVIGGCEDKIQ 200
Cdd:PHA03098 423 PLPISHYGGCAIyhDGKIYVIGGisyidNIKVYNIVESYNPVTNKWTELSSLNFPRIN-ASLCIFNNKIYVVGGDKYEYY 501

                         90       100
                 ....*....|....*....|
gi 145360201 201 ---VEVYDPKSRSWKTTKDP 217
Cdd:PHA03098 502 ineIEVYDDKTNTWTLFCKF 521
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 33-69 7.03e-04

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 36.29  E-value: 7.03e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 145360201  33 SLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPE 69
Cdd:cd22157    2 SLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPS 38
Kelch_4 pfam13418
Galactose oxidase, central domain;
175-217 1.46e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.67  E-value: 1.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 145360201  175 ARTDEASVGVINGKIYVIGGCEDKIQ----VEVYDPKSRSWKTTKDP 217
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTllsdLWVFDLSTNEWTRLGSL 47
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 31-70 2.62e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 34.77  E-value: 2.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 145360201   31 FTSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPEL 70
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSL 40
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 176-217 2.74e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 2.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 145360201  176 RTDEASVGVINGKIYVIGGCED-----KIQVEVYDPKSRSWKTTKDP 217
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGlgdlsSSDVLVYDPETNVWTEVPRL 47
Kelch smart00612
Kelch domain;
188-212 4.42e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.46  E-value: 4.42e-03
                           10        20
                   ....*....|....*....|....*...
gi 145360201   188 KIYVIGGCEDKI---QVEVYDPKSRSWK 212
Cdd:smart00612   1 KIYVVGGFDGGQrlkSVEVYDPETNKWT 28
Kelch_6 pfam13964
Kelch motif;
131-176 8.69e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 33.46  E-value: 8.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 145360201  131 HSMYNSSA-VGSEIYFVGGS---FEPMSELWILDTRTGMFRQGPSMKVAR 176
Cdd:pfam13964   1 PRTFHSVVsVGGYIYVFGGYtnaSPALNKLEVYNPLTKSWEELPPLPTPR 50
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 32-66 9.33e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 33.19  E-value: 9.33e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 145360201  32 TSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVR 66
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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