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Conserved domains on  [gi|15227777|ref|NP_179888|]
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Acyl-CoA N-acyltransferases (NAT) superfamily protein [Arabidopsis thaliana]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 107-168 4.09e-13

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 65.62  E-value: 4.09e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227777   107 YTKLAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHASVNLFTgKCGY 168
Cdd:pfam00583  56 EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYE-KLGF 116
yhbS super family cl43796
Predicted N-acetyltransferase YhbS [General function prediction only];
7-180 5.97e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


The actual alignment was detected with superfamily member COG3153:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 48.54  E-value: 5.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227777   7 VREYDPSkDLATVEDVERRCEVGPAgklslftdlLGDPICRVRHSPS-YLMLVAEIGpkekKELVGMIRGCIKTVTCGIT 85
Cdd:COG3153   1 IRPATPE-DAEAIAALLRAAFGPGR---------EAELVDRLREDPAaGLSLVAEDD----GEIVGHVALSPVDIDGEGP 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227777  86 TkrldlthnksqndvvitkplytklAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHAsvnlFTGK 165
Cdd:COG3153  67 A------------------------LLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLP----FYER 118

                       170
                ....*....|....*
gi 15227777 166 CGYAEFRTPSILVNP 180
Cdd:COG3153 119 FGFRPAGELGLTLGP 133
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 107-168 4.09e-13

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 65.62  E-value: 4.09e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227777   107 YTKLAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHASVNLFTgKCGY 168
Cdd:pfam00583  56 EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYE-KLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 111-173 3.68e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 56.20  E-value: 3.68e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227777 111 AYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHASVNLFTgKCGYAEFRT 173
Cdd:COG0456  14 AEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYE-KLGFEEVGE 75
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
7-180 5.97e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 48.54  E-value: 5.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227777   7 VREYDPSkDLATVEDVERRCEVGPAgklslftdlLGDPICRVRHSPS-YLMLVAEIGpkekKELVGMIRGCIKTVTCGIT 85
Cdd:COG3153   1 IRPATPE-DAEAIAALLRAAFGPGR---------EAELVDRLREDPAaGLSLVAEDD----GEIVGHVALSPVDIDGEGP 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227777  86 TkrldlthnksqndvvitkplytklAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHAsvnlFTGK 165
Cdd:COG3153  67 A------------------------LLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLP----FYER 118

                       170
                ....*....|....*
gi 15227777 166 CGYAEFRTPSILVNP 180
Cdd:COG3153 119 FGFRPAGELGLTLGP 133
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 111-146 4.45e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 43.80  E-value: 4.45e-06
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15227777 111 AYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEY 146
Cdd:cd04301  26 AYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKR 61
PRK07757 PRK07757
N-acetyltransferase;
109-137 5.84e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 37.10  E-value: 5.84e-03
                         10        20
                 ....*....|....*....|....*....
gi 15227777  109 KLAYILGLRVSPTHRRQGIGFKLVKAMED 137
Cdd:PRK07757  64 DLAEIRSLAVSEDYRGQGIGRMLVEACLE 92
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 107-168 4.09e-13

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 65.62  E-value: 4.09e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227777   107 YTKLAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHASVNLFTgKCGY 168
Cdd:pfam00583  56 EPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYE-KLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 111-173 3.68e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 56.20  E-value: 3.68e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227777 111 AYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHASVNLFTgKCGYAEFRT 173
Cdd:COG0456  14 AEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYE-KLGFEEVGE 75
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
7-180 5.97e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 48.54  E-value: 5.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227777   7 VREYDPSkDLATVEDVERRCEVGPAgklslftdlLGDPICRVRHSPS-YLMLVAEIGpkekKELVGMIRGCIKTVTCGIT 85
Cdd:COG3153   1 IRPATPE-DAEAIAALLRAAFGPGR---------EAELVDRLREDPAaGLSLVAEDD----GEIVGHVALSPVDIDGEGP 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227777  86 TkrldlthnksqndvvitkplytklAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHAsvnlFTGK 165
Cdd:COG3153  67 A------------------------LLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLP----FYER 118

                       170
                ....*....|....*
gi 15227777 166 CGYAEFRTPSILVNP 180
Cdd:COG3153 119 FGFRPAGELGLTLGP 133
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 100-186 7.92e-07

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 48.13  E-value: 7.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227777 100 VVITKPLYTKLAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHASVNLFTgKCGYAEFRTPSILVN 179
Cdd:COG0454  48 FAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYE-RLGFKEIERYVAYVG 126


                ....*..
gi 15227777 180 PVYAHRV 186
Cdd:COG0454 127 GEFEKEL 133
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 104-170 1.82e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 46.91  E-value: 1.82e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227777 104 KPLYTKLAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATendNHASVNLFTgKCGYAE 170
Cdd:COG1246  46 HPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLT---TSAAIHFYE-KLGFEE 108
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
118-170 4.16e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 46.53  E-value: 4.16e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15227777 118 VSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHASVNLFTgKCGYAE 170
Cdd:COG1247  88 VDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYE-KLGFEE 139
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
111-173 4.43e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 44.51  E-value: 4.43e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227777 111 AYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYFATENDNHASVNLFTgKCGYAEFRT 173
Cdd:COG3393  16 AEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYE-RLGFRPVGE 77
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 111-146 4.45e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 43.80  E-value: 4.45e-06
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 15227777 111 AYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEY 146
Cdd:cd04301  26 AYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKR 61
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 100-170 2.10e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 42.44  E-value: 2.10e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227777   100 VVITKPLYTKLAYILGLRVSPTHRRQGIGFKLVKAMEDWFSQNGAEYSYfaTENDNHAsVNLFTgKCGYAE 170
Cdd:pfam13508  18 AALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLE--LETTNRA-AAFYE-KLGFEE 84
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 114-168 2.84e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 37.71  E-value: 2.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15227777   114 LGLRVSPTHRRQGIGFKLVKAM-EDWFSQNGAEYSYFATENDNHASVNLFTgKCGY 168
Cdd:pfam13302  84 LGYWLGPDYWGKGYATEAVRALlEYAFEELGLPRLVARIDPENTASRRVLE-KLGF 138
PRK07757 PRK07757
N-acetyltransferase;
109-137 5.84e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 37.10  E-value: 5.84e-03
                         10        20
                 ....*....|....*....|....*....
gi 15227777  109 KLAYILGLRVSPTHRRQGIGFKLVKAMED 137
Cdd:PRK07757  64 DLAEIRSLAVSEDYRGQGIGRMLVEACLE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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