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Conserved domains on  [gi|15225317|ref|NP_180217|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-416 1.49e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.59  E-value: 1.49e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  96 EGH---IYSLA--ATKDLLYTGSDSKNIRVWkNLKEFSAFKCNSGL---VKAIVIS--GEKIFTGHQDGKIRVWKVSpKN 165
Cdd:cd00200   6 KGHtggVTCVAfsPDGKLLATGSGDGTIKVW-DLETGELLRTLKGHtgpVRDVAASadGTYLASGSSDKTIRLWDLE-TG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 166 QSLHkrsgtlpTLKDifkaslkprnyvevkkhrtalwikHADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLESIP 245
Cdd:cd00200  84 ECVR-------TLTG------------------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 246 AHDDAVNSV-VSTTEAIVFSGSADGTVKAWkrdqqgKYTKHTLMQTLTKQESAVTALAVSKNGAAVYFGSSDGLVNFWE- 323
Cdd:cd00200 133 GHTDWVNSVaFSPDGTFVASSSQDGTIKLW------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDl 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 324 REKQLnyGGILKGHKLAVLCLEVA--GSLVFSGSADKTICVWkrDGNIHTCLSVLTGHTGPVKCLAVEADREAserrdkk 401
Cdd:cd00200 207 STGKC--LGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKR------- 275

                       330
                ....*....|....*
gi 15225317 402 wiVYSGSLDKSVKVW 416
Cdd:cd00200 276 --LASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-416 1.49e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.59  E-value: 1.49e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  96 EGH---IYSLA--ATKDLLYTGSDSKNIRVWkNLKEFSAFKCNSGL---VKAIVIS--GEKIFTGHQDGKIRVWKVSpKN 165
Cdd:cd00200   6 KGHtggVTCVAfsPDGKLLATGSGDGTIKVW-DLETGELLRTLKGHtgpVRDVAASadGTYLASGSSDKTIRLWDLE-TG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 166 QSLHkrsgtlpTLKDifkaslkprnyvevkkhrtalwikHADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLESIP 245
Cdd:cd00200  84 ECVR-------TLTG------------------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 246 AHDDAVNSV-VSTTEAIVFSGSADGTVKAWkrdqqgKYTKHTLMQTLTKQESAVTALAVSKNGAAVYFGSSDGLVNFWE- 323
Cdd:cd00200 133 GHTDWVNSVaFSPDGTFVASSSQDGTIKLW------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDl 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 324 REKQLnyGGILKGHKLAVLCLEVA--GSLVFSGSADKTICVWkrDGNIHTCLSVLTGHTGPVKCLAVEADREAserrdkk 401
Cdd:cd00200 207 STGKC--LGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKR------- 275

                       330
                ....*....|....*
gi 15225317 402 wiVYSGSLDKSVKVW 416
Cdd:cd00200 276 --LASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
82-419 8.37e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 8.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  82 NLPQNGLIGSLVREEGHIYSLAATKD--LLYTGSDSKNIRVW--KNLKEFSAFKCNSGLVKAIVIS--GEKIFTGHQDGK 155
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWdlATGKLLRTLTGHSGAVTSVAFSpdGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 156 IRVWKVspknqslhkRSGTLP-TLKDifkaslkprnyvevkkhrtalwikHADAVSCLSLNDEQGLLYSASWDRTIKVWR 234
Cdd:COG2319 186 VRLWDL---------ATGKLLrTLTG------------------------HTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 235 IADSKCLESIPAHDDAVNSVV-STTEAIVFSGSADGTVKAWKRDQQgkytkhTLMQTLTKQESAVTALAVSKNGAAVYFG 313
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATG------ELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 314 SSDGLVNFWERE--KQLnygGILKGHKLAVLCLEVA--GSLVFSGSADKTICVWKRDGNihTCLSVLTGHTGPVKCLAVe 389
Cdd:COG2319 307 SDDGTVRLWDLAtgKLL---RTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATG--ELLRTLTGHTGAVTSVAF- 380

                       330       340       350
                ....*....|....*....|....*....|
gi 15225317 390 adreaseRRDKKWIVySGSLDKSVKVWGVS 419
Cdd:COG2319 381 -------SPDGRTLA-SGSADGTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 223-380 2.04e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  223 SASWDRTIKVWRIADSKCLESIPAHDDAVNSV--VSTTEAIVFSGSADGTVKAWKRDQQgkytkhTLMQTLTKQESAVTA 300
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIdySSADPTLLASGSDDGSVKLWSINQG------VSIGTIKTKANICCV 623

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  301 LAVSKNGAAVYFGSSDGLVNFWE-REKQLNYGGILKGHKLAVLCLEVAGSLVFSGSADKTICVWKRDGNI----HTCLSV 375
Cdd:PLN00181 624 QFPSESGRSLAFGSADHKVYYYDlRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSIsginETPLHS 703


                 ....*
gi 15225317  376 LTGHT 380
Cdd:PLN00181 704 FMGHT 708
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 205-316 1.18e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 47.37  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317   205 HADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLES-----------------------IPAHDDAVNSVVSTTEA- 260
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKrsrntqtefprkdhviaetpfhiLCGHDDIITCLYVSVELd 202

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15225317   261 IVFSGSADGTVkAWKRDQQGKYTK---HtlmqtltKQESAVTALAVSKNGAAVYFGSSD 316
Cdd:pfam20426 203 IVISGSKDGTC-IFHTLREGRYVRsirH-------PSGCPLSKLVASRHGRIVLYADDD 253
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 205-233 2.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.99e-04
                           10        20
                   ....*....|....*....|....*....
gi 15225317    205 HADAVSCLSLNDEQGLLYSASWDRTIKVW 233
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-416 1.49e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.59  E-value: 1.49e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  96 EGH---IYSLA--ATKDLLYTGSDSKNIRVWkNLKEFSAFKCNSGL---VKAIVIS--GEKIFTGHQDGKIRVWKVSpKN 165
Cdd:cd00200   6 KGHtggVTCVAfsPDGKLLATGSGDGTIKVW-DLETGELLRTLKGHtgpVRDVAASadGTYLASGSSDKTIRLWDLE-TG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 166 QSLHkrsgtlpTLKDifkaslkprnyvevkkhrtalwikHADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLESIP 245
Cdd:cd00200  84 ECVR-------TLTG------------------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 246 AHDDAVNSV-VSTTEAIVFSGSADGTVKAWkrdqqgKYTKHTLMQTLTKQESAVTALAVSKNGAAVYFGSSDGLVNFWE- 323
Cdd:cd00200 133 GHTDWVNSVaFSPDGTFVASSSQDGTIKLW------DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDl 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 324 REKQLnyGGILKGHKLAVLCLEVA--GSLVFSGSADKTICVWkrDGNIHTCLSVLTGHTGPVKCLAVEADREAserrdkk 401
Cdd:cd00200 207 STGKC--LGTLRGHENGVNSVAFSpdGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKR------- 275

                       330
                ....*....|....*
gi 15225317 402 wiVYSGSLDKSVKVW 416
Cdd:cd00200 276 --LASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
82-419 8.37e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 8.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  82 NLPQNGLIGSLVREEGHIYSLAATKD--LLYTGSDSKNIRVW--KNLKEFSAFKCNSGLVKAIVIS--GEKIFTGHQDGK 155
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWdlATGKLLRTLTGHSGAVTSVAFSpdGKLLASGSDDGT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 156 IRVWKVspknqslhkRSGTLP-TLKDifkaslkprnyvevkkhrtalwikHADAVSCLSLNDEQGLLYSASWDRTIKVWR 234
Cdd:COG2319 186 VRLWDL---------ATGKLLrTLTG------------------------HTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 235 IADSKCLESIPAHDDAVNSVV-STTEAIVFSGSADGTVKAWKRDQQgkytkhTLMQTLTKQESAVTALAVSKNGAAVYFG 313
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATG------ELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 314 SSDGLVNFWERE--KQLnygGILKGHKLAVLCLEVA--GSLVFSGSADKTICVWKRDGNihTCLSVLTGHTGPVKCLAVe 389
Cdd:COG2319 307 SDDGTVRLWDLAtgKLL---RTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATG--ELLRTLTGHTGAVTSVAF- 380

                       330       340       350
                ....*....|....*....|....*....|
gi 15225317 390 adreaseRRDKKWIVySGSLDKSVKVWGVS 419
Cdd:COG2319 381 -------SPDGRTLA-SGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
82-367 4.75e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 4.75e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  82 NLPQNGLIGSLVREEGHIYSLAATKD--LLYTGSDSKNIRVW--KNLKEFSAFKCNSGLVKAIVIS--GEKIFTGHQDGK 155
Cdd:COG2319 148 DLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGT 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 156 IRVWKVspknqslhkRSGTLP-TLKDifkaslkprnyvevkkhrtalwikHADAVSCLSLNDEQGLLYSASWDRTIKVWR 234
Cdd:COG2319 228 VRLWDL---------ATGKLLrTLTG------------------------HSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 235 IADSKCLESIPAHDDAVNSVV-STTEAIVFSGSADGTVKAWKRDQQgkytkhTLMQTLTKQESAVTALAVSKNGAAVYFG 313
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAfSPDGKLLASGSDDGTVRLWDLATG------KLLRTLTGHTGAVRSVAFSPDGKTLASG 348

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15225317 314 SSDGLVNFWEREKQLNyGGILKGHKLAVLCLEVA--GSLVFSGSADKTICVWKRDG 367
Cdd:COG2319 349 SDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
198-419 1.39e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 1.39e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 198 RTALWIKHADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLESIPAHDDAVNSV-VSTTEAIVFSGSADGTVKAWKR 276
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVaFSPDGKTLASGSADGTVRLWDL 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 277 DQQgkytkhTLMQTLTKQESAVTALAVSKNGAAVYFGSSDGLVNFWEREKQlNYGGILKGHKLAVLCLEVA--GSLVFSG 354
Cdd:COG2319 150 ATG------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSpdGKLLASG 222

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15225317 355 SADKTICVWKRDGNihTCLSVLTGHTGPVKCLAVEADReaserrdkKWIVySGSLDKSVKVWGVS 419
Cdd:COG2319 223 SADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSPDG--------RLLA-SGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-420 1.70e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 1.70e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 205 HADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLESIPAHDDAVNSV--VSTTEAIvFSGSADGTVKAWKRDQQgky 282
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaaSADGTYL-ASGSSDKTIRLWDLETG--- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 283 tkhTLMQTLTKQESAVTALAVSKNGAAVYFGSSDGLVNFWEREKqLNYGGILKGHKLAVLCLEVAGS--LVFSGSADKTI 360
Cdd:cd00200  84 ---ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDgtFVASSSQDGTI 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 361 CVWkrDGNIHTCLSVLTGHTGPVKCLAVEADREAserrdkkwiVYSGSLDKSVKVWGVSE 420
Cdd:cd00200 160 KLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEK---------LLSSSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 82-323 3.86e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.12  E-value: 3.86e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  82 NLPQNGLIGSLVREEGHIYSLAATKD--LLYTGSDSKNIRVW--KNLKEFSAFKCNSGLVKAIVISGEK--IFTGHQDGK 155
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGT 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 156 IRVWKVSpKNQSLHKRSGtlptlkdifkaslkprnyvevkkhrtalwikHADAVSCLSLNDEQGLLYSASWDRTIKVWRI 235
Cdd:cd00200 159 IKLWDLR-TGKCVATLTG-------------------------------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 236 ADSKCLESIPAHDDAVNSV-VSTTEAIVFSGSADGTVKAWKRDQQgkytkhTLMQTLTKQESAVTALAVSKNGAAVYFGS 314
Cdd:cd00200 207 STGKCLGTLRGHENGVNSVaFSPDGYLLASGSEDGTIRVWDLRTG------ECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                ....*....
gi 15225317 315 SDGLVNFWE 323
Cdd:cd00200 281 ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
205-416 1.83e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 1.83e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 205 HADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLESIPAHDDAVNSVV-STTEAIVFSGSADGTVKAWKRDQqgkyt 283
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAfSPDGRLLASASADGTVRLWDLAT----- 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 284 kHTLMQTLTKQESAVTALAVSKNGAAVYFGSSDGLVNFWERE--KQLnygGILKGHKLAVLCLEVA--GSLVFSGSADKT 359
Cdd:COG2319 110 -GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtgKLL---RTLTGHSGAVTSVAFSpdGKLLASGSDDGT 185

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15225317 360 ICVWKRDGNihTCLSVLTGHTGPVKCLAVeadreaseRRDKKWIVySGSLDKSVKVW 416
Cdd:COG2319 186 VRLWDLATG--KLLRTLTGHTGAVRSVAF--------SPDGKLLA-SGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 287-416 1.81e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 1.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317 287 LMQTLTKQESAVTALAVSKNGAAVYFGSSDGLVNFWEREKQLnYGGILKGHKLAVL-CLEVA-GSLVFSGSADKTICVWK 364
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRdVAASAdGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15225317 365 RDGNihTCLSVLTGHTGPVKCLAVEADREaserrdkkwIVYSGSLDKSVKVW 416
Cdd:cd00200  80 LETG--ECVRTLTGHTSYVSSVAFSPDGR---------ILSSSSRDKTIKVW 120
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 223-380 2.04e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  223 SASWDRTIKVWRIADSKCLESIPAHDDAVNSV--VSTTEAIVFSGSADGTVKAWKRDQQgkytkhTLMQTLTKQESAVTA 300
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIdySSADPTLLASGSDDGSVKLWSINQG------VSIGTIKTKANICCV 623

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317  301 LAVSKNGAAVYFGSSDGLVNFWE-REKQLNYGGILKGHKLAVLCLEVAGSLVFSGSADKTICVWKRDGNI----HTCLSV 375
Cdd:PLN00181 624 QFPSESGRSLAFGSADHKVYYYDlRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSIsginETPLHS 703


                 ....*
gi 15225317  376 LTGHT 380
Cdd:PLN00181 704 FMGHT 708
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 205-316 1.18e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 47.37  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317   205 HADAVSCLSLNDEQGLLYSASWDRTIKVWRIADSKCLES-----------------------IPAHDDAVNSVVSTTEA- 260
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKrsrntqtefprkdhviaetpfhiLCGHDDIITCLYVSVELd 202

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15225317   261 IVFSGSADGTVkAWKRDQQGKYTK---HtlmqtltKQESAVTALAVSKNGAAVYFGSSD 316
Cdd:pfam20426 203 IVISGSKDGTC-IFHTLREGRYVRsirH-------PSGCPLSKLVASRHGRIVLYADDD 253
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 205-233 2.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.99e-04
                           10        20
                   ....*....|....*....|....*....
gi 15225317    205 HADAVSCLSLNDEQGLLYSASWDRTIKVW 233
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
371-416 3.07e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15225317   371 TCLSVLTGHTGPVKCLAVEADREaserrdkkwIVYSGSLDKSVKVW 416
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK---------LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 371-416 4.22e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 15225317    371 TCLSVLTGHTGPVKCLAVEADREaserrdkkwIVYSGSLDKSVKVW 416
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK---------YLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
205-233 4.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.50e-04
                          10        20
                  ....*....|....*....|....*....
gi 15225317   205 HADAVSCLSLNDEQGLLYSASWDRTIKVW 233
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 217-317 8.00e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.60  E-value: 8.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317   217 EQGLLYSASWDRTIKVWRIADSKCLESIPAHDDAVNSV-VSTTEAIVFSGSADGTVKAWK-----------RDQQGKYTK 284
Cdd:pfam20426  93 ENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVaVTSDGSILATGSYDTTVMVWEvlrgrssekrsRNTQTEFPR 172

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 15225317   285 --HTLMQT----LTKQESAVTALAVSKNGAAVYFGSSDG 317
Cdd:pfam20426 173 kdHVIAETpfhiLCGHDDIITCLYVSVELDIVISGSKDG 211
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-275 8.84e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15225317    237 DSKCLESIPAHDDAVNSV-VSTTEAIVFSGSADGTVKAWK 275
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVaFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
238-274 8.97e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.97e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15225317   238 SKCLESIPAHDDAVNSV-VSTTEAIVFSGSADGTVKAW 274
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
332-363 2.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 15225317   332 GILKGHKLAVLCLEVA--GSLVFSGSADKTICVW 363
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 333-364 2.91e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.91e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 15225317    333 ILKGHKLAVLCLEVA--GSLVFSGSADKTICVWK 364
Cdd:smart00320   7 TLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 322-410 9.53e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.13  E-value: 9.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225317   322 WEREKQ---LNYGGILKG---HKLAVLCLEVA--GSLVFSGSADKTICVW---------KRDGNIHTCLS---------- 374
Cdd:pfam20426 102 WENSFQvisLNDGRMVQSirqHKDVVSCVAVTsdGSILATGSYDTTVMVWevlrgrsseKRSRNTQTEFPrkdhviaetp 181

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 15225317   375 --VLTGHTGPVKCLAVEADREaserrdkkwIVYSGSLD 410
Cdd:pfam20426 182 fhILCGHDDIITCLYVSVELD---------IVISGSKD 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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