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Conserved domains on  [gi|15226403|ref|NP_180416|]
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RmlC-like cupins superfamily protein [Arabidopsis thaliana]

Protein Classification

vicilin family protein( domain architecture ID 14388890)

vicilin family protein is a cupin domain-containing protein similar to 7S seed storage proteins, such as cupincin, beta-conglycinin, vicilin, provicilin, canavalin, convicilin, and conglutin beta, and Ara h 1, a major peanut allergen

CATH:  2.60.120.10
Gene Ontology:  GO:0045735
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 94-254 9.17e-68

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380371  Cd Length: 178  Bit Score: 215.45  E-value: 9.17e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  94 VIKSEGGEMRVVLSPRGR----IIEKPMHIGFLTMEPKTLFVPQYLDSSLLIFIRQGEATLGVICKDEFGERKLKAGDIY 169
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRsrllRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 170 WIPAGSVFYLHNTGLGQRLHVICSIDPTQSLGFETFQPFYIGGG--PSSVLAGFDPHTLTSAFNVSLPELQQMMMSQFRG 247
Cdd:cd02244  81 RIPAGSTFYLVNTDENEKLRIIALFDPVNSLTPGPFQSFFGAGGqnPESLLSGFSKEILEAAFNVSEEELERLLSQQKPG 160


                ....*..
gi 15226403 248 PIVYVTE 254
Cdd:cd02244 161 PIVKASE 167
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 338-489 1.15e-64

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380372  Cd Length: 166  Bit Score: 206.98  E-value: 1.15e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 338 PSFDNKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTS----------- 406
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLSSqsqqgeeegsg 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 407 ---AMNTRVSVGDVFWIPRYFAFCQIASRTGPFEFVGFTTSAHKNRPQFLVGSNSLLRTLNLTSLSIAFGVDEETMRRFI 483
Cdd:cd02245  81 eyqKVRARLSEGDVFVVPAGHPVAQVASSNENLEFVGFGINAQNNERQFLAGKNNVLRQLDREAKELAFNVPAEEVEEVL 160


                ....*.
gi 15226403 484 EAQREA 489
Cdd:cd02245 161 NAQDES 166
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 94-254 9.17e-68

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 215.45  E-value: 9.17e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  94 VIKSEGGEMRVVLSPRGR----IIEKPMHIGFLTMEPKTLFVPQYLDSSLLIFIRQGEATLGVICKDEFGERKLKAGDIY 169
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRsrllRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 170 WIPAGSVFYLHNTGLGQRLHVICSIDPTQSLGFETFQPFYIGGG--PSSVLAGFDPHTLTSAFNVSLPELQQMMMSQFRG 247
Cdd:cd02244  81 RIPAGSTFYLVNTDENEKLRIIALFDPVNSLTPGPFQSFFGAGGqnPESLLSGFSKEILEAAFNVSEEELERLLSQQKPG 160


                ....*..
gi 15226403 248 PIVYVTE 254
Cdd:cd02244 161 PIVKASE 167
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 338-489 1.15e-64

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 206.98  E-value: 1.15e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 338 PSFDNKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTS----------- 406
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLSSqsqqgeeegsg 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 407 ---AMNTRVSVGDVFWIPRYFAFCQIASRTGPFEFVGFTTSAHKNRPQFLVGSNSLLRTLNLTSLSIAFGVDEETMRRFI 483
Cdd:cd02245  81 eyqKVRARLSEGDVFVVPAGHPVAQVASSNENLEFVGFGINAQNNERQFLAGKNNVLRQLDREAKELAFNVPAEEVEEVL 160


                ....*.
gi 15226403 484 EAQREA 489
Cdd:cd02245 161 NAQDES 166
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 337-480 4.86e-45

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 155.13  E-value: 4.86e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403    337 KPSFDNKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTSAMNTRVSVGD 416
Cdd:smart00835   4 RPDFSNEGGRLREADPTNFPALNGLGISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNGNKVYDARLREGD 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15226403    417 VFWIPRYFAFCQIASRTGPFEFVGFTTSAhKNRPQFLVGSNSLLRTLNLTSLSIAFGVDEETMR 480
Cdd:smart00835  84 VFVVPQGHPHFQVNSGDENLEFVAFNTND-PNRRFFLAGRNSVLRGLPPEVLAAAFGVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 329-480 8.22e-37

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 133.23  E-value: 8.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403   329 YNIYDKKdkPSFDNKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFP-NGTSA 407
Cdd:pfam00190   1 LNLLEPG--PTYNPEGGRVTTVNSKNLPGLNTLGISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVPgNGNRV 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15226403   408 MNTRVSVGDVFWIPRYFAFCQIASRTGP-FEFVGFTTSAHKNRPQFLVGsNSLLRTLNLTSLSIAFGVDEETMR 480
Cdd:pfam00190  79 FHKVLREGDVFVVPQGLPHFQYNIGDEPaVAFVAFDTNNPGNQSILAGG-FSSLPALPPEVLAKAFQLAGEEVK 151
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 89-238 1.38e-21

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 90.80  E-value: 1.38e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403     89 RESRQVIKSEGGEMRVVLSPRGRIIEKP-MHIGFLTMEPKTLFVPQY-LDSSLLIFIRQGEATLGVIC--KDEFGERKLK 164
Cdd:smart00835   1 LEPRPDFSNEGGRLREADPTNFPALNGLgISAARVNLEPGGMLPPHYhPRATELLYVVRGEGRVGVVDpnGNKVYDARLR 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15226403    165 AGDIYWIPAGSVFYLHNTGlGQRLHVICSIDPTQSlgfetfQPFYIGGGpSSVLAGFDPHTLTSAFNVSLPELQ 238
Cdd:smart00835  81 EGDVFVVPQGHPHFQVNSG-DENLEFVAFNTNDPN------RRFFLAGR-NSVLRGLPPEVLAAAFGVSAEEVR 146
PLN00212 PLN00212
glutelin; Provisional
 122-481 2.44e-13

glutelin; Provisional


Pssm-ID: 215106 [Multi-domain]  Cd Length: 493  Bit Score: 72.15  E-value: 2.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  122 LTMEPKTLFVPQYLDSSLLIFIRQGEATLGVI---C----------------------KDEFGE-RKLKAGDIYWIPAGS 175
Cdd:PLN00212  85 RVIEPQGLLLPRYSNTPGLVYIIQGRGSMGLTfpgCpatyqqqfqqfltegqsqsqkfRDEHQKiHQFRQGDVVALPAGV 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  176 VFYLHNTGLGQ--RLHVI------CSIDPTQslgfetfQPFYIGGGPSS----------------VLAGFDPHTLTSAFN 231
Cdd:PLN00212 165 AHWFYNDGDAPvvALYVYdinnnaNQLEPRQ-------REFLLAGNNNRqqqvygrsieqhsgqnIFSGFSTELLSEALG 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  232 VSLPELQQMM-MSQFRGPIVYVTEGPQP-QPQSTVwtqflglrGEEKHKQLKKLlETKQGSPQDQQYSSGwSWRNIVRSI 309
Cdd:PLN00212 238 INAQVAKRLQsQNDQRGEIIRVKNGLQLlQPTLTQ--------QQEQAQQQQQR-LYQQVQYQQSQQTSG-RWNGLDENF 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  310 LDLTEEKNKGSGSSEceDSYNiydkkdkPsfdnKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGI 389
Cdd:PLN00212 308 CTIKVRLNIENPSRA--DTYN-------P----RAGRITRLNSQKFPILNLIQMSATRVNLYQNALLSPFWNVNAHSVVY 374

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  390 VLAGSGEIQVVFPNGTSAMNTRVSVGDVFWIPRYFAFCQIASRTGpFEFVGFTTSAHKNRPQfLVGSNSLLRTLNLTSLS 469
Cdd:PLN00212 375 ITQGRARVQVVSNNGKTVFNGVLRPGQLLIIPQHYAVLKKAEREG-CQYIAFKTNANAMVSH-IAGKNSIFRALPVDVIA 452

                        410
                 ....*....|..
gi 15226403  470 IAFGVDEETMRR 481
Cdd:PLN00212 453 NAYRISREEARR 464
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 121-238 8.57e-06

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 45.79  E-value: 8.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403   121 FLTMEPKTLFVPQY-LDSSLLIFIRQGEATLGVICKDEF---GERKLKAGDIYWIPAGSVFYLHNTGLGQRLHVICsIDp 196
Cdd:pfam00190  37 RVDLAPGGMNPPHWhPNATEILYVLQGRGRVGFVVPGNGnrvFHKVLREGDVFVVPQGLPHFQYNIGDEPAVAFVA-FD- 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15226403   197 TQSLGFETfqpfyIGGGPSSVLAGFDPHTLTSAFNVSLPELQ 238
Cdd:pfam00190 115 TNNPGNQS-----ILAGGFSSLPALPPEVLAKAFQLAGEEVK 151
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 362-446 3.00e-05

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 43.42  E-value: 3.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 362 GIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIqVVFPNGTSAMNTRVSVGDVFWIPRYFAFCQIASRTGPFEFVGF 441
Cdd:COG2140   2 TLAGGLTVLEPGGVREEHWHPNAAEWYYVLSGEARM-TVQDPPGRARTVDVGPGDVVYVPPGYGHYIINTGDEPLVFLAV 80


                ....*
gi 15226403 442 TTSAH 446
Cdd:COG2140  81 FDDDA 85
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
117-192 1.90e-04

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 40.90  E-value: 1.90e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15226403 117 MHIGFLTMEPKTLFVPQY-LDSSLLIFIRQGEATlgVICKDEfgERKLKAGDIYWIPAGSVFYLHNTGlGQRLHVIC 192
Cdd:COG0662  27 LSVKRITVPPGAELSLHVhPHRDEFFYVLEGTGE--VTIGDE--EVELKAGDSVYIPAGVPHRLRNPG-DEPLELLE 98
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 94-254 9.17e-68

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 215.45  E-value: 9.17e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  94 VIKSEGGEMRVVLSPRGR----IIEKPMHIGFLTMEPKTLFVPQYLDSSLLIFIRQGEATLGVICKDEFGERKLKAGDIY 169
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRsrllRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESYNLERGDVY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 170 WIPAGSVFYLHNTGLGQRLHVICSIDPTQSLGFETFQPFYIGGG--PSSVLAGFDPHTLTSAFNVSLPELQQMMMSQFRG 247
Cdd:cd02244  81 RIPAGSTFYLVNTDENEKLRIIALFDPVNSLTPGPFQSFFGAGGqnPESLLSGFSKEILEAAFNVSEEELERLLSQQKPG 160


                ....*..
gi 15226403 248 PIVYVTE 254
Cdd:cd02244 161 PIVKASE 167
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 338-489 1.15e-64

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 206.98  E-value: 1.15e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 338 PSFDNKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTS----------- 406
Cdd:cd02245   1 PDFSNQYGWLYEADPEDYKQLKDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLSSqsqqgeeegsg 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 407 ---AMNTRVSVGDVFWIPRYFAFCQIASRTGPFEFVGFTTSAHKNRPQFLVGSNSLLRTLNLTSLSIAFGVDEETMRRFI 483
Cdd:cd02245  81 eyqKVRARLSEGDVFVVPAGHPVAQVASSNENLEFVGFGINAQNNERQFLAGKNNVLRQLDREAKELAFNVPAEEVEEVL 160


                ....*.
gi 15226403 484 EAQREA 489
Cdd:cd02245 161 NAQDES 166
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 337-480 4.86e-45

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 155.13  E-value: 4.86e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403    337 KPSFDNKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTSAMNTRVSVGD 416
Cdd:smart00835   4 RPDFSNEGGRLREADPTNFPALNGLGISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNGNKVYDARLREGD 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15226403    417 VFWIPRYFAFCQIASRTGPFEFVGFTTSAhKNRPQFLVGSNSLLRTLNLTSLSIAFGVDEETMR 480
Cdd:smart00835  84 VFVVPQGHPHFQVNSGDENLEFVAFNTND-PNRRFFLAGRNSVLRGLPPEVLAAAFGVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 329-480 8.22e-37

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 133.23  E-value: 8.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403   329 YNIYDKKdkPSFDNKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFP-NGTSA 407
Cdd:pfam00190   1 LNLLEPG--PTYNPEGGRVTTVNSKNLPGLNTLGISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVPgNGNRV 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15226403   408 MNTRVSVGDVFWIPRYFAFCQIASRTGP-FEFVGFTTSAHKNRPQFLVGsNSLLRTLNLTSLSIAFGVDEETMR 480
Cdd:pfam00190  79 FHKVLREGDVFVVPQGLPHFQYNIGDEPaVAFVAFDTNNPGNQSILAGG-FSSLPALPPEVLAKAFQLAGEEVK 151
cupin_11S_legumin_C cd02243
11S legumin seed storage globulin, C-terminal cupin domain; This family contains the ...
 358-493 3.72e-27

11S legumin seed storage globulin, C-terminal cupin domain; This family contains the C-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380370  Cd Length: 155  Bit Score: 106.79  E-value: 3.72e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 358 LKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTSAMNTRVSVGDVFWIPRYFAFCQIASRTGpFE 437
Cdd:cd02243  21 LRFVGLSAERVKLEPNAMFAPHWNANAHQVIYVTRGSGRVQVVGDNGKRVLDGEVREGQLLVVPQFFAVAKIAGEEG-FE 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15226403 438 FVGFTTSAhknRPQF--LVGSNSLLRTLNLTSLSIAFGVDEETMRRFIEA-QREAVILP 493
Cdd:cd02243 100 WVSFKTSD---NPIFseLAGRTSVLRALPPEVLANSYNISPEEAKQLKSNrEKETVLFP 155
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 89-238 1.38e-21

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 90.80  E-value: 1.38e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403     89 RESRQVIKSEGGEMRVVLSPRGRIIEKP-MHIGFLTMEPKTLFVPQY-LDSSLLIFIRQGEATLGVIC--KDEFGERKLK 164
Cdd:smart00835   1 LEPRPDFSNEGGRLREADPTNFPALNGLgISAARVNLEPGGMLPPHYhPRATELLYVVRGEGRVGVVDpnGNKVYDARLR 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15226403    165 AGDIYWIPAGSVFYLHNTGlGQRLHVICSIDPTQSlgfetfQPFYIGGGpSSVLAGFDPHTLTSAFNVSLPELQ 238
Cdd:smart00835  81 EGDVFVVPQGHPHFQVNSG-DENLEFVAFNTNDPN------RRFFLAGR-NSVLRGLPPEVLAAAFGVSAEEVR 146
cupin_11S_legumin_N cd02242
11S legumin seed storage globulin, N-terminal cupin domain; This family contains the ...
 89-252 6.41e-16

11S legumin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380369  Cd Length: 209  Bit Score: 76.47  E-value: 6.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  89 RESRQVIKSEGGemrvvlsprgrIIEK--PMH-------IGF--LTMEPKTLFVPQYLDSSLLIFIRQGEATLGVI---C 154
Cdd:cd02242   7 LEPTRRIESEGG-----------SYEYwdPNNpqlqcagVAAgrLTIEPRGLLLPSYSNAPKLAYVLQGRGIVGVVfpgC 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 155 KDEFGE------------------RKLKAGDIYWIPAGSVFYLHNTGlGQRLHVICSIDpTQSLGF---ETFQPFYIGGG 213
Cdd:cd02242  76 PETFQSsqqsqgqgqrfrdqhqkvRRIRKGDVIAVPAGVVHWWYNDG-DSDLVIVFLGD-TSNNANqldGNFRRFFLAGN 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 15226403 214 PS--------------SVLAGFDPHTLTSAFNVSLPELQQMMMSQF-RGPIVYV 252
Cdd:cd02242 154 PQqeqqgqgqeqsgggNIFSGFSTEFLAEAFGVDEETARKLQGSQDqRGLIVKV 207
cupin_7S_11S_C cd20285
7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal ...
 350-453 4.49e-15

7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal cupin domains of 7S and 11S seed storage proteins. The 7S globulins include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The 11S globulins include many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380420  Cd Length: 109  Bit Score: 71.10  E-value: 4.49e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 350 LDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTSAMNTRVSVGDVFWIPRYFAFCQi 429
Cdd:cd20285   6 RTSNDFPILKSLNLLASSISLEEGAMFVPHYYSKAIVILVVNEGRAHIQVVGPKGYESYDAELSKGDVFVVPAAFPVAI- 84

                        90       100
                ....*....|....*....|....
gi 15226403 430 ASRTGPFEFVGFTTSAHKNRPQFL 453
Cdd:cd20285  85 KSTSHNVEFTGFGTNANNNNRNLL 108
PLN00212 PLN00212
glutelin; Provisional
 122-481 2.44e-13

glutelin; Provisional


Pssm-ID: 215106 [Multi-domain]  Cd Length: 493  Bit Score: 72.15  E-value: 2.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  122 LTMEPKTLFVPQYLDSSLLIFIRQGEATLGVI---C----------------------KDEFGE-RKLKAGDIYWIPAGS 175
Cdd:PLN00212  85 RVIEPQGLLLPRYSNTPGLVYIIQGRGSMGLTfpgCpatyqqqfqqfltegqsqsqkfRDEHQKiHQFRQGDVVALPAGV 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  176 VFYLHNTGLGQ--RLHVI------CSIDPTQslgfetfQPFYIGGGPSS----------------VLAGFDPHTLTSAFN 231
Cdd:PLN00212 165 AHWFYNDGDAPvvALYVYdinnnaNQLEPRQ-------REFLLAGNNNRqqqvygrsieqhsgqnIFSGFSTELLSEALG 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  232 VSLPELQQMM-MSQFRGPIVYVTEGPQP-QPQSTVwtqflglrGEEKHKQLKKLlETKQGSPQDQQYSSGwSWRNIVRSI 309
Cdd:PLN00212 238 INAQVAKRLQsQNDQRGEIIRVKNGLQLlQPTLTQ--------QQEQAQQQQQR-LYQQVQYQQSQQTSG-RWNGLDENF 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  310 LDLTEEKNKGSGSSEceDSYNiydkkdkPsfdnKYGWSIALDYDDYKPLKHSGIGVYLVNLTAGAMMAPHMNPTATEYGI 389
Cdd:PLN00212 308 CTIKVRLNIENPSRA--DTYN-------P----RAGRITRLNSQKFPILNLIQMSATRVNLYQNALLSPFWNVNAHSVVY 374

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  390 VLAGSGEIQVVFPNGTSAMNTRVSVGDVFWIPRYFAFCQIASRTGpFEFVGFTTSAHKNRPQfLVGSNSLLRTLNLTSLS 469
Cdd:PLN00212 375 ITQGRARVQVVSNNGKTVFNGVLRPGQLLIIPQHYAVLKKAEREG-CQYIAFKTNANAMVSH-IAGKNSIFRALPVDVIA 452

                        410
                 ....*....|..
gi 15226403  470 IAFGVDEETMRR 481
Cdd:PLN00212 453 NAYRISREEARR 464
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 331-477 2.78e-10

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 58.76  E-value: 2.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 331 IYDKKDKPSFDNKYGWSIALDYDDYKPLKhsGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTsaMNT 410
Cdd:cd20306   4 FSLEDSNPFFESEGGSIRQATADQLPVLK--GLSIYRLRLSPGGIREPHWHPNANELGYVISGEARVSILDPTGS--LDT 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15226403 411 -RVSVGDVFWIPRYFAFCQIASRTGPFEFVGFTTSahkNRPQFLVGSNSllrtLNLTS---LSIAFGVDEE 477
Cdd:cd20306  80 fTVKPGQVVFIPQGWLHWIENVGDEEAHLLIFFNH---ETPEDIGLSDS----LRATPpevLGNTYGVDAF 143
cupin_OxDC cd02240
Oxalate decarboxylase (OxDC), cupin domain; Oxalate decarboxylase (OxDC; EC 4.1.1.2) is a ...
 338-472 1.86e-06

Oxalate decarboxylase (OxDC), cupin domain; Oxalate decarboxylase (OxDC; EC 4.1.1.2) is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds and both domains are included in this alignment. Each OxDC cupin domain contains one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380367 [Multi-domain]  Cd Length: 145  Bit Score: 47.47  E-value: 1.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 338 PSFDNKYGWSIALDYDDYKPLKhsGIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVVFPNGTSAMNTrVSVGDV 417
Cdd:cd02240   4 PIEENAGGSVRIATVTNFPISK--DLSSALVRVAPGAMRELHWHPNTAEWQYVISGSARVTVFDEDGRFETFN-LGAGDV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15226403 418 FWIPRYF-----------AFCQIASRTGPFEFVGFTTSAHKNRPQFLVGsnsllrTLNLTSLSIAF 472
Cdd:cd02240  81 GYVPSGSghhienigdedAEFLLIFDDGTFADVSLPWWLAMTPEEVLAA------TLDLGKFIDAL 140
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 121-238 8.57e-06

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 45.79  E-value: 8.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403   121 FLTMEPKTLFVPQY-LDSSLLIFIRQGEATLGVICKDEF---GERKLKAGDIYWIPAGSVFYLHNTGLGQRLHVICsIDp 196
Cdd:pfam00190  37 RVDLAPGGMNPPHWhPNATEILYVLQGRGRVGFVVPGNGnrvFHKVLREGDVFVVPQGLPHFQYNIGDEPAVAFVA-FD- 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 15226403   197 TQSLGFETfqpfyIGGGPSSVLAGFDPHTLTSAFNVSLPELQ 238
Cdd:pfam00190 115 TNNPGNQS-----ILAGGFSSLPALPPEVLAKAFQLAGEEVK 151
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 362-446 3.00e-05

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 43.42  E-value: 3.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 362 GIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIqVVFPNGTSAMNTRVSVGDVFWIPRYFAFCQIASRTGPFEFVGF 441
Cdd:COG2140   2 TLAGGLTVLEPGGVREEHWHPNAAEWYYVLSGEARM-TVQDPPGRARTVDVGPGDVVYVPPGYGHYIINTGDEPLVFLAV 80


                ....*
gi 15226403 442 TTSAH 446
Cdd:COG2140  81 FDDDA 85
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 119-192 4.99e-05

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 41.70  E-value: 4.99e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15226403 119 IGFLTMEPKTLFVPQYLDSSL-LIFIRQGEATLGVICKDEFgerKLKAGDIYWIPAGSVFYLHNTGlGQRLHVIC 192
Cdd:cd02208   1 ISVVTLPPGTSSPPHWHPEQDeIFYVLSGEGELTLDDGETV---ELKAGDIVLIPPGVPHSFVNTS-DEPAVFLV 71
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 140-232 5.26e-05

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 43.35  E-value: 5.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403 140 LIFIRQGEATLGVI-CKDEFGERKLKAGDIYWIPAGSVFYLHNTGlGQRLHVIcsidptqsLGFETFQPFYIGGgpSSVL 218
Cdd:cd20306  58 LGYVISGEARVSILdPTGSLDTFTVKPGQVVFIPQGWLHWIENVG-DEEAHLL--------IFFNHETPEDIGL--SDSL 126

                        90
                ....*....|....
gi 15226403 219 AGFDPHTLTSAFNV 232
Cdd:cd20306 127 RATPPEVLGNTYGV 140
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
117-192 1.90e-04

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 40.90  E-value: 1.90e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15226403 117 MHIGFLTMEPKTLFVPQY-LDSSLLIFIRQGEATlgVICKDEfgERKLKAGDIYWIPAGSVFYLHNTGlGQRLHVIC 192
Cdd:COG0662  27 LSVKRITVPPGAELSLHVhPHRDEFFYVLEGTGE--VTIGDE--EVELKAGDSVYIPAGVPHRLRNPG-DEPLELLE 98
cupin_OxOx cd02241
Oxalate oxidase (germin), cupin domain; Oxalate oxidase (OxOx, also known as germin; EC 1.2.3. ...
 362-422 1.90e-04

Oxalate oxidase (germin), cupin domain; Oxalate oxidase (OxOx, also known as germin; EC 1.2.3.4) catalyzes the manganese-dependent oxidative decarboxylation of oxalate to carbon dioxide and hydrogen peroxide (H2O2). It is widespread in fungi and various plant tissues and may play a role in plant signaling and defense. This enzyme has been employed in a widely used assay for detecting urinary oxalate levels. Also, the gene encoding OxOx from barley roots has been expressed in oilseed rape in order to provide a defense against externally supplied oxalic acid. In germin, the predominant protein produced during the early phase of wheat germination, it is believed that H2O2 production is employed as a defense mechanism in response to infection by pathogens. Germin is also a marker of growth onset in cell walls in germinating cereals. The H2O2 produced by OxOx, together with the Ca2+ released by degradation of calcium oxalate, are thought to mediate cell wall cross-linking at high concentrations. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380368  Cd Length: 191  Bit Score: 42.58  E-value: 1.90e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15226403 362 GIGVYLVNLTAGAMMAPHMNPTATEYGIVLagSGEIQVVF--PNGTSAMNTRVSVGDVFWIPR 422
Cdd:cd02241  69 GISMARGDLAPCGVNPPHTHPRATELLYVV--EGTLYVGFvdENGNRLFTKTLNPGDVFVFPQ 129
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
95-196 2.61e-04

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 40.22  E-value: 2.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15226403  95 IKSEGGEMRVVLSPRGRiiekpMHIGFLTMEPKTLFVPQYLDSSLLIFIRQGEATLGVickdEFGERKLKAGDIYWIPAG 174
Cdd:COG1917   6 IALTGVSVRVLADGEDE-----LEVVRVTFEPGARTPWHSHPGEELIYVLEGEGEVEV----GGEEYELKPGDVVFIPPG 76

                        90       100
                ....*....|....*....|..
gi 15226403 175 SVFYLHNTGlGQRLHVICSIDP 196
Cdd:COG1917  77 VPHAFRNLG-DEPAVLLVVFSP 97
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
359-422 7.85e-04

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 39.06  E-value: 7.85e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15226403 359 KHSGIGVYLVNLTAGAMMAPHMNPTaTEYGIVLAGSGEIQVvfpNGTSamnTRVSVGDVFWIPR 422
Cdd:COG1917  19 GEDELEVVRVTFEPGARTPWHSHPG-EELIYVLEGEGEVEV---GGEE---YELKPGDVVFIPP 75
cupin_7S_11S_C cd20285
7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal ...
 119-173 1.07e-03

7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal cupin domains of 7S and 11S seed storage proteins. The 7S globulins include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The 11S globulins include many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380420  Cd Length: 109  Bit Score: 38.74  E-value: 1.07e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15226403 119 IGFLTMEPKTLFVPQY-LDSSLLIFIRQGEATLGVI-CKDEFGER-KLKAGDIYWIPA 173
Cdd:cd20285  21 ASSISLEEGAMFVPHYySKAIVILVVNEGRAHIQVVgPKGYESYDaELSKGDVFVVPA 78
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 366-422 1.32e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 37.24  E-value: 1.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15226403   366 YLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVvfpNGTSamnTRVSVGDVFWIPR 422
Cdd:pfam07883   1 GLVTLPPGESSPPHRHPGEDEFFYVLEGEGELTV---DGEE---VVLKAGDSVYFPA 51
cupin_MJ1618 cd02214
Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes ...
 142-196 2.01e-03

Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes bacterial and archaeal proteins homologous to MJ1618, a Methanocaldococcus jannaschii protein of unknown function with a cupin beta barrel domain. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion.


Pssm-ID: 380344 [Multi-domain]  Cd Length: 100  Bit Score: 37.50  E-value: 2.01e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15226403 142 FIRQGEATLGVicKDEfgERKLKAGDIYWIPAGSVFYLHNTGlGQRLHVICSIDP 196
Cdd:cd02214  45 YILEGEGTMEI--DGE--PREVGPGDAVLIPPGAVQRIENTG-EEDLVFLCICSP 94
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
362-422 3.36e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 37.43  E-value: 3.36e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15226403 362 GIGVYLVNLTAGAMMAPHMNPTATEYGIVLAGSGEIQVvfpNGTSamnTRVSVGDVFWIPR 422
Cdd:COG0662  26 RLSVKRITVPPGAELSLHVHPHRDEFFYVLEGTGEVTI---GDEE---VELKAGDSVYIPA 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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