|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
106-505 |
1.88e-177 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 502.86 E-value: 1.88e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 106 VLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATIL 185
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 186 TPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYS 265
Cdd:cd17380 81 TPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 266 FGSLGTVWLTLWLTKAesspledptllpeerkliadncaskepvksipwrlilskPPVWALISCHFCHNWGTFILLTWMP 345
Cdd:cd17380 161 FGLLGLLWALVWLIYL---------------------------------------PPVWAIIVAHFCMNWGFYILLSWLP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 346 TYYHQVLkFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLC 425
Cdd:cd17380 202 TYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLC 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 426 MACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQ-HGSWDDVFTISVGLYLVGTVIWNLF 504
Cdd:cd17380 281 MSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEaTGSWSLVFVLAAVVNLVGAVVFLLF 360
|
.
gi 15227589 505 S 505
Cdd:cd17380 361 G 361
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
107-504 |
1.28e-122 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 364.25 E-value: 1.28e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 107 LLCFSAFLLCNMDRVNMSIAILPMSA----------------------EYGWNPATVGLIQSSFFWGYLLTQIAGGIWAD 164
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAIVAMVNstathdnnntstdkdtlpveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 165 TVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSV 244
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 245 TGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWltkaesspledptllpeerkliadncaskepvksipWRLIlskPPVW 324
Cdd:cd17318 162 IAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW------------------------------------FFLV---LPVW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 325 ALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRG-FSVTNVRKIMQTIGF 403
Cdd:cd17318 203 AIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGF 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 404 LGPAFFLTQLKHI-DSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQH-- 480
Cdd:cd17318 283 LGPGVFLIALGYLgSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVKNdq 362
|
410 420
....*....|....*....|....*.
gi 15227589 481 --GSWDDVFTISVGLYLVGTVIWNLF 504
Cdd:cd17318 363 tiGQWRIVFFISAAIYILGAIFYLIF 388
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
108-504 |
4.12e-84 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 264.97 E-value: 4.12e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 108 LCFSAFLLCNMDRVNMSIAILPM---------------SAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVL 172
Cdd:cd17382 3 MAGLGFCISFGIRCNLGVAIVRMvnnftdayggkvivhKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 173 GFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPF 252
Cdd:cd17382 83 GLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 253 LIHQFGWPSVFYSFGSLGTVWLTLWltkaesspledptllpeerkliadncaskepvksipwrlILSKPPVWALISCHFC 332
Cdd:cd17382 163 LVQYVGWSSPFYVYGVFGIIWYMFW---------------------------------------MLVSMPVYAIIVANFC 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 333 HNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRG-FSVTNVRKIMQTIGFLGPAFFLT 411
Cdd:cd17382 204 RSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGiLSTTAVRKIFNCGGFGMEATFLL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 412 QLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGS---WDDVFT 488
Cdd:cd17382 284 VVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTreeWQYVFL 363
|
410
....*....|....*.
gi 15227589 489 ISVGLYLVGTVIWNLF 504
Cdd:cd17382 364 IASLVHFFGVIFYAIF 379
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
106-504 |
8.64e-80 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 254.70 E-value: 8.64e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 106 VLLCFSAFLLCNMdRVNMSIAILPM------------------------------SAEYGWNPATVGLIQSSFFWGYLLT 155
Cdd:cd17381 3 LLAFFGFFVVYAL-RVNLSVALVDMvnsnstlpsnnssnacpehssspsvehnetGKKYDWDAETQGWILGSFFYGYIIT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 156 QIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALV 235
Cdd:cd17381 82 QIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTIS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 236 YSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTkaesspledptllpeerkliadncaskepvksipwr 315
Cdd:cd17381 162 YAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIW------------------------------------ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 316 LILskpPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSR-GFSVTNV 394
Cdd:cd17381 206 LVM---PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKqNFSTVCV 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 395 RKIMQTIGFLGPAFFLTQLKHID-SPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAA 473
Cdd:cd17381 283 RKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGPVI 362
|
410 420 430
....*....|....*....|....*....|....
gi 15227589 474 TGHILQH---GSWDDVFTISVGLYLVGTVIWNLF 504
Cdd:cd17381 363 AKSLTHNntvEEWQTVFYISAAINVFGAIFFTIF 396
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
133-508 |
7.50e-70 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 230.79 E-value: 7.50e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 133 EYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAM 212
Cdd:TIGR00894 70 NFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 213 PAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLI-HQFGWPSVFYSFGSLGTVWLTLWLTkaesSPLEDPTL 291
Cdd:TIGR00894 150 PATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFV----FPADDPSI 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 292 LPEERKLIADNCASK------EPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVF 365
Cdd:TIGR00894 226 HPCISKFEKKYINSSlqgqkgSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSL 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 366 PWMTMAISANAGGWIADTLVSRG-FSVTNVRKIMQTIGFLGPAFFLTQLKHIDSP---TMAVLCMAcsQGTDAFSQSGLY 441
Cdd:TIGR00894 306 PYLFAWLCSIFAGYLADFLKSSKtLSLTAARKIFNGIGGLGPGIFAYALPYLSAAfylTIIILTLA--NAVSSGPLAGVL 383
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 442 SNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGS---WDDVFTISVGLYLVGTVIWNLFSTGE 508
Cdd:TIGR00894 384 INSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQDSknvWLIVFLIMAFVNILCVIFYLIFGSAE 453
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
100-501 |
1.55e-69 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 226.68 E-value: 1.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 100 PKRWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWW 179
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 180 SIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGW 259
Cdd:COG2271 86 GLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 260 PSVFYSFGSLGTVWLTLwltkaesspledptllpeerkliadncaskepvksipwrlilskpPVWALISCHFCHNWGTFI 339
Cdd:COG2271 164 RAAFLILGLPGLLLALL---------------------------------------------RFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 340 LLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRgfsvtnvRKIMQTIGFLGPAFFLTQLKHIDSP 419
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAALALLLLALLPSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 420 TMAVLCMACSQGTDAFSQSGLYSNHQDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGT 498
Cdd:COG2271 272 ALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAA 351
|
...
gi 15227589 499 VIW 501
Cdd:COG2271 352 LLA 354
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
102-501 |
2.74e-68 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 223.22 E-value: 2.74e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 102 RWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSI 181
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 182 ATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPS 261
Cdd:cd17319 81 FTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 262 VFYSFGSLGTVWLTLWltkaesspledptllpeerkliadncaskepvksipWRLIlskPPVWALISCHFCHNWGTFILL 341
Cdd:cd17319 159 AFIIEGLLGLLLAVLW------------------------------------WFYL---RQVWGLALGYFGINYALYGLL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 342 TWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTM 421
Cdd:cd17319 200 TWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 422 AVLCMACSQGTDAFSQSGLYSNHQDIAPR-YSGVLLGLSNTAGVLAGVLGTAATGHILQH-GSWDDVFTISVGLYLVGTV 499
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAAL 353
|
..
gi 15227589 500 IW 501
Cdd:cd17319 354 LV 355
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
108-471 |
3.23e-47 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 167.21 E-value: 3.23e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 108 LCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTP 187
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 188 VAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFG 267
Cdd:pfam07690 81 FAS--SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 268 SLGTVWLTLWLTKAESSPLEDPTLLPEERKLIAdncaskepvksIPWRLILSKPPVWALISChFCHNWGTFILLTWMPTy 347
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI-----------VAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPL- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 348 YHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMA 427
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15227589 428 CSQGTDAFSQSGLYSNHQDIAP-RYSGVLLGLSNTAGVLAGVLGT 471
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
112-500 |
1.72e-45 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 164.05 E-value: 1.72e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 112 AFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTpvAAK 191
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQ--AFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 192 LGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGT 271
Cdd:TIGR00893 80 GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 272 VWLTLWLTKAESSPLEDPTLLPEERKLIAD----NCASKEPVKSIPWRL--ILSKPPVWALISCHFCHNWGTFILLTWMP 345
Cdd:TIGR00893 160 IWGVLWLKFIPDPPQKAKWLTEEEKYIVVGgllaEQQGKGPSTPKKYQIkeLLKDRRVWGLALGQFLVNIGLGFFLTWFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 346 TYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGFSVtNVRKIMQTIGFLGpAFFLTQLKHIDSPTMAVLC 425
Cdd:TIGR00893 240 TYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSL-VFARKTAIIAGLV-LSLLMFATNYVNIPYAALA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227589 426 MACSQGTDAFSQSGLYSNHQDIAPRYS-GVLLGLSNTAGVLAGVLGTAATGHIL-QHGSWDDVFTISVGLYLVGTVI 500
Cdd:TIGR00893 318 LVALGFFGLGAGAIGWALISDNAPGNIaGLTGGLINSLGNLGGIVGPIVIGAIAaTTGSFAGALMVVAALALIGALS 394
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
100-501 |
2.55e-40 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 149.65 E-value: 2.55e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 100 PKRWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWW 179
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 180 SIATILTPVAAKLGLpyLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGW 259
Cdd:COG2223 81 GIGLLLLALAVSYWL--LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 260 PSVFYSFGSLGTVWLTLWLTKAESSPLEDPTllpeerkliadncASKEPVKSipWRLILSKPPVWALISCHFCHNWGTFI 339
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAA-------------AAKASLRD--QLEALRDPRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 340 LLTWMPTYYHQVLKFNLMESGLL-SVFPWMTMAISAnAGGWIADTLvsRGFSVTNVRKIMQTIGFLGPAFFLTqlkhidS 418
Cdd:COG2223 224 FSSWLPPYLVDQFGLSAATAGLLaALFALLGALGRP-LGGWLSDRI--GGRRVLLIVFALMALGLLLLALALG------S 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 419 PTMAVLCMACSQGTDAFSQSGLYSNHQDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQH-GSWDDVFTISVGLYLV 496
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALV 374
|
....*
gi 15227589 497 GTVIW 501
Cdd:COG2223 375 ALVLT 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-469 |
1.28e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 138.57 E-value: 1.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 100 PKRWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWW 179
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 180 SIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGW 259
Cdd:COG2814 86 ALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 260 PSVFYSFGSLGTV-WLTLWLTKAESSPLEDPTLLPEerkliadncaskepvksipWRLILSKPPVWALISCHFCHNWGTF 338
Cdd:COG2814 164 RWVFLVNAVLALLaLLLLLRLLPESRPAARARLRGS-------------------LRELLRRPRLLLLLLLAFLLGFGFF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 339 ILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDS 418
Cdd:COG2814 225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---------GRRRLLLIGLLLLALGLLLLALAGS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15227589 419 PTMAVLCMACSQGTDAFSQSGLYSNHQDIAP-RYSGVLLGLSNTAGVLAGVL 469
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
110-500 |
2.33e-33 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 130.24 E-value: 2.33e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 110 FSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVA 189
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 190 AklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLI--HQFGWPSVFYSFG 267
Cdd:cd06174 82 P--SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 268 SLGTVWLTLWLTKAESSPLEDPtllpeerkliADNCASKEPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTY 347
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESAR----------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 348 YHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSrgfsvtnvRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMA 427
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227589 428 CSQGTDAFSQSGLYS-NHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHIL-QHGSWDDVFTISVGLYLVGTVI 500
Cdd:cd06174 302 LLGFGLGGLLPLSFAlIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
108-505 |
1.19e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 111.13 E-value: 1.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 108 LCFSAFLLcnMDRVNMSIAILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILT 186
Cdd:cd17325 1 LSLALFLD--MLGYGIIIPILPlYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 187 PVAAKLglPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSF 266
Cdd:cd17325 79 AFATSY--WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 267 GSLGTvwLTLWLTkaesspledpTLLPEERKLIADNCASKEPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPT 346
Cdd:cd17325 157 AALAL--LALVLA----------LLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 347 YYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCM 426
Cdd:cd17325 225 YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 427 ACSQGTDAFSQSGLYSNHQDIAPRYS-GVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIWNLFS 505
Cdd:cd17325 296 ALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
123-501 |
3.33e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 98.01 E-value: 3.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 123 MSIAILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVR 201
Cdd:cd17324 17 VIQGLLPdIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 202 AFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLG---TVWLTLWL 278
Cdd:cd17324 95 ALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAllaALLLWRLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 279 tkaesspledPTLLPEERKliadncaSKEPVKSipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKF-NLM 357
Cdd:cd17324 175 ----------PSLPPKKPG-------SLGLLSS--LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFsSSA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 358 ESGLLSVFpWMTMAISANAGGWIADTLVsrgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFsQ 437
Cdd:cd17324 236 IIGLLLLF-GVAGVVGSPLAGRLADRGG--------RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA-H 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227589 438 SGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIW 501
Cdd:cd17324 306 SALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
100-478 |
2.01e-21 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 96.27 E-value: 2.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 100 PKRWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWW 179
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 180 SIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGW 259
Cdd:TIGR00895 93 SVFTLLCALAT--NVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 260 PSVFYsFGSLGTVWLTLWLTKAESSPLE-----------------DPTLLPEERKLIADNcASKEPVKSIPWRLILSK-- 320
Cdd:TIGR00895 171 RSLFY-VGGIAPLLLLLLLMRFLPESIDflvskrpetvrrivnaiAPQMQAEAQSALPEQ-KSTQGTKRSVFKALFQGkt 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 321 ----PPVWAlisCHFCHNWGTFILLTWMPTYYHQvLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtNVRK 396
Cdd:TIGR00895 249 aritVLLWL---LYFMLLVGVYFLTNWLPKLMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRL--------GPRV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 397 IMqtIGFLGPAFFLTQL-KHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAP---RYSGVLLGLSntAGVLAGVLGTA 472
Cdd:TIGR00895 317 TA--LLLLLGAVFAVLVgSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPtaiRATGVGWAIG--IGRLGAIIGPI 392
|
....*.
gi 15227589 473 ATGHIL 478
Cdd:TIGR00895 393 LAGYLL 398
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
110-487 |
1.60e-20 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 93.21 E-value: 1.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 110 FSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILtpVA 189
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 190 AKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQF-GWPSVFYSFGS 268
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 269 LGTVWLTLWLTKAESSPL--------EDPTLLPEERKLIADNCASKepvKSIPWRLILSKPPVWALISCHFCHNWGTFIL 340
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSPQscglppaeEMPNEEPDGDAEKKEEELTK---KQIFLQYVLLNKVLWYISLGYVFVYVVRTGI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 341 LTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLV-SRGFSVTNVRKIMQTIGFLGPAFFLTQlkhidSP 419
Cdd:TIGR00881 236 LDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFnGRRGPLAVFFMALIIVSLLVYWLNPAA-----NP 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227589 420 TMAVLCMACSQGTDAFSQSGLYSNHQDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVF 487
Cdd:TIGR00881 311 LMDLICLFALGFLVYGPQMLIGVIASELAPkKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
106-481 |
9.03e-20 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 90.72 E-value: 9.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 106 VLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATIL 185
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 186 TPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYS 265
Cdd:cd17365 81 TAFAQ--SVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 266 FGSLGTVWLtlwltkaessPLEDPTLLpeerkliadncaskepvksipwrlilskppVWAlisCHFCHNWGTFILLTWMP 345
Cdd:cd17365 159 GGVPPLILL----------PLLRGTLL------------------------------LWV---TFFMGLLLVYLLNSWLP 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 346 TYYhQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLC 425
Cdd:cd17365 196 KLM-VEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRF--------GPKRVLALFFALGAVSLALLGVSPASLVLLYVL 266
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15227589 426 MACSQGTDAFSQSGLYSNHQDIAP---RYSGVllGLSNTAGVLAGVLGTAATGHILQHG 481
Cdd:cd17365 267 VFLAGACVNGAQVGLYALAARFYPtevRATGV--GWALGVGRLGAILGPLLGGLLLAAG 323
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
100-283 |
2.56e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 88.33 E-value: 2.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 100 PKRWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWW 179
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 180 SIATILTPVAakLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGW 259
Cdd:COG0477 90 GLASLLCGLA--PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
170 180
....*....|....*....|....
gi 15227589 260 PSVFYSFGSLGTVWLTLWLTKAES 283
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRLPES 191
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
100-496 |
5.32e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 88.76 E-value: 5.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 100 PKRWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWW 179
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 180 SIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRsLALVYSGMYLGSVTGLAFSPFLIHQFGW 259
Cdd:COG0738 84 ALGLLLFALAP--SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 260 PSVFYSFGSLGTVWLTLWLTKAesspledPTLLPEERKLIADNCASKEPVKSipwrlILSKPPVWALISCHFCHNWGTFI 339
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFL-------RSKLPEIEEEEEEAAGSAASLKS-----LLKNPRLLLGGLAIFLYVGAEGA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 340 LLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAIsanaGGWIADTLVSRgFSVTNVRKIMQTIGFLGPAFFLTqlkhIDSP 419
Cdd:COG0738 229 IGDWLPLYLKDVLGLSEATAALGLSLFWGGMTI----GRFLGGFLLKR-FGPVRLLRLSALLAAVGLLLALL----APGP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 420 TMAVLCMACSqgtdAFSQSGLY----SNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYL 495
Cdd:COG0738 300 WLALIGLALV----GLGLSLMFptifSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYL 375
|
.
gi 15227589 496 V 496
Cdd:COG0738 376 L 376
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
100-500 |
1.00e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.01 E-value: 1.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 100 PKRWVIVLLCFsaFLLCNMDRVNMSIAIL--PMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVI 177
Cdd:COG2807 14 AGRWLLLLAIV--LVALNLRPAITSVGPLlpEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 178 WWSIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPvQERSRSLALVYSGMYLGSVTGLAFSPFLIHQF 257
Cdd:COG2807 92 LLAAGLLLRSLAP--SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 258 GWPSVFYSFGSLGTVWLTLWLTkaesspledptLLPEERKliadncASKEPVKSIPWRLILSKPPVWALISCHFCHNWGT 337
Cdd:COG2807 169 GWRGALAVWALLALLALLLWLP-----------LLRRRPA------AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 338 FILLTWMPTYYHQvLKFNLMESG-LLSVFPWMTMAISAnAGGWIADTLVSRGFSVTnVRKIMQTIGFLGPAFFLTQLkhi 416
Cdd:COG2807 232 YAVVAWLPPILRD-AGLSAATAGlLLSLFQLAGIPGSL-LVPLLADRLGDRRPLLL-LLGLLGLAGLLGLLLAPGSL--- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 417 dsPTMAVLCMACSQGTdAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQH-GSWDDVFTISVGLYL 495
Cdd:COG2807 306 --PWLWAVLLGLGQGG-LFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtGSWTAALLLLAALAV 382
|
....*
gi 15227589 496 VGTVI 500
Cdd:COG2807 383 LMLVA 387
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
107-430 |
2.46e-18 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 86.91 E-value: 2.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 107 LLCFSAfLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILT 186
Cdd:cd17328 3 VLFLIN-LLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 187 PVAAKLGLpyLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQF-GWPSVFYS 265
Cdd:cd17328 82 SFAPNFWQ--LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 266 FGSLGTVWLTL-WLTkaesspLEDPTLLPEERKLIADNCASKEPVKsipWRLILSKPPVWALISCHFCHNWGTFILLTWM 344
Cdd:cd17328 160 TGVLGVLLAILlLLF------VREPPRGAAEGGVMAKSTATSFLAD---LKALAKNPSFILSTLGFTAVSFVTGALAFWA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 345 PTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvSRGFSVTNVR--KIMQTIGFLG--PAFFLTQLKHIDSPT 420
Cdd:cd17328 231 PTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGIL-ADRLRRKTPRadPLVCAVGLLAaaPFLFLALVLALSNLL 309
|
330
....*....|
gi 15227589 421 MAVLCMACSQ 430
Cdd:cd17328 310 LAWVLLFLGE 319
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
86-269 |
5.56e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.62 E-value: 5.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 86 DSPSSIVLPWWEEFPKRWVIVLLCFSAFLlcNMDRVNMSIAILP--MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWA 163
Cdd:cd17325 182 AVSAARLRSGLRLLLRDRRLLALFLAIFV--LAFAFGALEPFLPlyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLS 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 164 DTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGS 243
Cdd:cd17325 260 DRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGM 337
|
170 180
....*....|....*....|....*.
gi 15227589 244 VTGLAFSPFLIHQFGWPSVFYSFGSL 269
Cdd:cd17325 338 VLGPLLGGFLYDAFGFATPFLAAAAL 363
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
106-501 |
5.62e-17 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 82.26 E-value: 5.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 106 VLLCFSAFLLCNMDRVNMSIAILPMSAEYGWN--PATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIAT 183
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGlsLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 184 ILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLG----SVTGLAFSPFLIHQFGW 259
Cdd:cd17316 81 LLIGLLP--TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGallaALVASLLIPLLSGDWGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 260 PSVFYsFGSLGTVwLTLWLtkaesspledptllpeeRKLIadncaskepvksipwrlilskppvWALISCHFCHNWGTFI 339
Cdd:cd17316 159 RILFL-IGALPAL-LALLL-----------------RRRT------------------------LLLILLWFFISFGYYG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 340 LLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrGfsvtnvRKIMQTIGFL--GPAFFLTQLKHID 417
Cdd:cd17316 196 LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---G------RKKTLVIGLIlsGILALPLFYLLSG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 418 SPTMAVLCMACSQGTDAFSQSGLYSNHQDIAP---RYSGVllGLSNTAGVLAGVLGTAATGHIL-QHGSWDDVFTISVGL 493
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVWGALYAYLAELFPtevRATGV--GLSYNLGRLGGGGAPPLIALLLaSTGGTGVPALILALL 344
|
....*...
gi 15227589 494 YLVGTVIW 501
Cdd:cd17316 345 AIVALIVA 352
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
130-500 |
1.73e-15 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 78.05 E-value: 1.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 130 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGViwWSIATILTPVAAKLGLPYLLVVRAFMGVGEG 209
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGL--LLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 210 VAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGS---LGTVWLTLWLTKAESSPL 286
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLvsiLAAVLFWLFYREPPAASA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 287 EDPTLLPEERKLiadncaskepvksipwRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFP 366
Cdd:cd17475 180 ATESASTLLRSL----------------KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 367 WMTMAISANAGGWIADTLVSRgfsvtNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLC-MACSQGTDAFSQSGLYSNH- 444
Cdd:cd17475 244 QLGGALGRIGLGRVSDRVFGG-----RRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVlLLILLGLFAIGWNGLYLTLv 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15227589 445 QDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQH-GSWDDVFTISVGLYLVGTVI 500
Cdd:cd17475 319 AESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDAtHSYAPAWLALALLLVLAALL 376
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
108-501 |
7.83e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 76.19 E-value: 7.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 108 LCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTP 187
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 188 VAAKLGLpyLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLG-----SVTGLAFsPFLIHQFGWPSV 262
Cdd:cd17371 83 FAQNYWQ--LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllatLLAALLF-PLLPPEIAWRVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 263 FYS--FGSLGTVWLTLWLTKAESspledptllpeerklIADNCASKEPVKSIPWRLILSKPP------VWALISChfCHN 334
Cdd:cd17371 160 FLLgaLPALLVLFIRRFVKEPPQ---------------WQAARAARRHFADRPSLRELFSPPllrttlLASLLAT--GAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 335 WGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtnVRKIMQTIGFLGPAFFL---T 411
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI---------GRRNNFALFALGSAISIllyF 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 412 QLkHIDSPTMAVLCMACsqgtdAFSQSGLYSNHQDIAP-----RYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDD- 485
Cdd:cd17371 294 FL-PLSPTLILILGFPL-----GFFASGPFSGMGAYLTelfptAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTa 367
|
410
....*....|....*...
gi 15227589 486 --VFTISVGLYLVGTVIW 501
Cdd:cd17371 368 iaVFAAVYYIAGLVLALL 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
137-501 |
1.55e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 75.34 E-value: 1.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 137 NPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLgFGVIWWSIATILTPVAA----KLGLPYLLVVRAFMGVGEGVAM 212
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL-ILADLLRALLAAVLALLallgSLSLWLLLVLAFLLGIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 213 PAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFY--SFGSLGTVWLTLWLTKAESSPLEDPT 290
Cdd:cd06173 111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAinALSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 291 LLPEERKLIAdncaskepvksipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLsvfpwmtM 370
Cdd:cd06173 191 SLLLRDLREG-------------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL-------L 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 371 AISAnAGGWIADTLVSRGFSVTNVRKIMqTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAP- 449
Cdd:cd06173 251 AAFG-VGALLGALLLGRLSKRRRRGRLL-LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPd 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15227589 450 RYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIW 501
Cdd:cd06173 329 ELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
108-481 |
6.39e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 73.36 E-value: 6.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 108 LCFSAFllcnMDRVNMSIA--ILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATI 184
Cdd:cd17321 1 LLLAVF----LAALDVTIVnvALPtIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 185 LTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFY 264
Cdd:cd17321 77 LCALAP--SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 265 SFGSLGtvwltlwltkaesspledptllpeerkLIAdncaskepvksipwrLILSKPPVWALIsCHFCHNWGTFILLTWM 344
Cdd:cd17321 155 INVPIG---------------------------LVA---------------LLLARTFSGAVL-AAFLLGAALGGLLFLL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 345 PTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGFSVTNVrkIMQTIGFLGPAFFLTqlkHIDSPTMAVL 424
Cdd:cd17321 192 PLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL--LLTAVGLLLLALLGA---DSSVWLLLPG 266
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15227589 425 CMACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHG 481
Cdd:cd17321 267 LVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
104-264 |
6.65e-14 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 73.46 E-value: 6.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 104 VIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIAT 183
Cdd:PRK11551 15 LTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 184 ILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVF 263
Cdd:PRK11551 95 LATAQAW--DFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF 172
|
.
gi 15227589 264 Y 264
Cdd:PRK11551 173 Y 173
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
103-389 |
1.14e-13 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 72.67 E-value: 1.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 103 WVIVLLCFSAFLLCNMDRVNMSIA-ILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSI 181
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAaVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 182 ATILTpvAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTG--LAFSPFLIHQF-- 257
Cdd:cd17327 84 LTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGglLAYGVFKILGVgg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 258 --GWPSVFYSFG---SLGTVWLTLWLTKaesSPLEDPTLLPEERKL----IADNCASKEPVKSIP--WRLILSKPPVWAL 326
Cdd:cd17327 162 laGWRWLFIIEGlitIIIGLVIFFWLPD---NPSKAWFLTEEEKELaverLRANQTGKGDQKFKWkqIKEAFKDPRTWLL 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227589 327 ISCHFCHNWGTFILLTWMPTYYHQvLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGF 389
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPLILKS-LGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGL 300
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
102-499 |
1.38e-13 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 72.31 E-value: 1.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 102 RWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSI 181
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 182 ATILtpVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPS 261
Cdd:cd17312 81 ANIF--MGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 262 VFYSFGSLGTVwltlwltkaesspledptllpeerkliadncaskepVKSIPWRLILSKPP-VWALISCHFCHNWGTFIL 340
Cdd:cd17312 159 AFLVPGIVGLV------------------------------------VAIILFFFLRDSPPyVWVLSLAYAFVYIVRYAC 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 341 LTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPT 420
Cdd:cd17312 203 LDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 421 MAV-----------LCMACSqgtdafsqsglysnhQDIAPRY-SGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFT 488
Cdd:cd17312 283 LFLigffvggpinlIGGAAA---------------QDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFY 347
|
410
....*....|.
gi 15227589 489 ISVGLYLVGTV 499
Cdd:cd17312 348 FLISAALLSVL 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
103-294 |
4.59e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.70 E-value: 4.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 103 WVIVLLCFSAFllcnmdrvNMSIAILPMSA-EYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSI 181
Cdd:cd17489 2 LLANFFFFLSF--------YLLLPVLPLYAhDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 182 ATILTPVAAKLGLpyLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPS 261
Cdd:cd17489 74 ATLLYLLATSVAL--LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV 151
|
170 180 190
....*....|....*....|....*....|....
gi 15227589 262 VFY-SFGSLGTVWLTLWLTKAESSPLEDPTLLPE 294
Cdd:cd17489 152 LFIvAAVLALLALLLVFLVKDPPPVAAEEAEAGT 185
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
103-504 |
1.42e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.14 E-value: 1.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 103 WVIVLLCFSAFLlcnmdRVNMSIAILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSI 181
Cdd:cd17474 2 YAVFFATLLAVL-----GVSIVDPILPaIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 182 ATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGsvtgLAFSPFL---IHQFG 258
Cdd:cd17474 77 GGLLCGLSD--SFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLG----IAVGPLLgglLAAIS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 259 WPSVFYSFGSLGTVWLTLWLTKAESSPLEDPTLLPEERKLiadncaskepvksipWRLILSKPPVWALISCHFCHNWGTF 338
Cdd:cd17474 151 WRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD---------------LKKALRGRGLLTFLVSAFLYFFLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 339 ILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIadtlVSRGFSvtnVRKIMqTIGFLGPAFFLTQLKHIDS 418
Cdd:cd17474 216 AFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRL----LKKRFG---ARRIL-VIGLLLYALSLLLLGFVPS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 419 PTMAVLCMACS---QGTDAFSQSGLYSNHQDIAPRysGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYL 495
Cdd:cd17474 288 LALLLIAIVLFglgLGLNLPLLTTLVTELAPEEER--GTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIAL 365
|
....*....
gi 15227589 496 VGTVIWNLF 504
Cdd:cd17474 366 AAAVLLALL 374
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
112-483 |
7.06e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 66.83 E-value: 7.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 112 AFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSffwgYLLTQIAG----GIWADTVGGKRVLGFGVIWWSIATILTP 187
Cdd:cd17503 4 GAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITS----YLLALAIMiplsGWLADRFGTRRLFLTALALFTLGSLLCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 188 VAAKLglPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFG 267
Cdd:cd17503 80 LAPNL--ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 268 SLGTVWLTLwltkaesSPLEDPTLLpeerkliadncasKEPVKSIpwrlilskppvwALISChFCHNWGTFILLTWMPTY 347
Cdd:cd17503 158 PIGILALLL-------APLLDLRLF-------------KDRNFTL------------GLLLS-FLLGLGLFGAMFLLPLY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 348 YHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtNVRKIMqTIGFLGPAFFLTQLKHIdSPTMAVLCMA 427
Cdd:cd17503 205 LQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF--------GPRLLL-LAGLLLLALGTLLLAFL-TPDTSLWLII 274
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227589 428 CSQGTDAFSQSGLYSN-----HQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSW 483
Cdd:cd17503 275 LPLFIRGLGMGLVFMPlntlaLNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQ 335
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
103-272 |
8.32e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.83 E-value: 8.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 103 WVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIA 182
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 183 TILTPVAAKLGLPYLL--VVrafMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWP 260
Cdd:cd17355 82 LVLLALATSLWQLYLLwgLL---GGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170
....*....|..
gi 15227589 261 SVFYSFGSLGTV 272
Cdd:cd17355 159 TALLVLALLALL 170
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
120-500 |
9.79e-11 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 63.80 E-value: 9.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 120 RVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVA--AKLGLPYL 197
Cdd:cd17345 19 RNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsATSSVGLM 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 198 LVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYS-----GMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTV 272
Cdd:cd17345 99 FILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIshnvgGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 273 WLTLWLTK--AES---SPLEdpTLLPEERKLIADNCASKE-PVKSIPWRLILSKPPVWALISChfchnwGTFI------L 340
Cdd:cd17345 179 VIVLFLGKdtPESeglPPIE--EYKGDYPEEADGEEEEQElSAWEIFVKYVLKNKLLWYIAIA------NVFVylvrygI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 341 LTWMPTYYHQVLKFNLMES-GLLSVFPWMTMAISANAgGWIADTLVSrgfsvtNVRKIMQTIGFLGPAFFLTQLKHIDSP 419
Cdd:cd17345 251 LDWAPTYLSEVKGFSKAQAmWAFSLFEWAAIPGTLLA-GWLSDKLFK------GRRAPTGIIFMILVIVALIVYWLAPNV 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 420 TMAVLCMACSqGTDAFSQS---GLYSNhqDIAPRYS-GVLLGLSNTAGVLAG-VLGTAATGHILQHGSWDDVFT---ISV 491
Cdd:cd17345 324 LVDLIALIAL-GFLIYGPVmliGLQAL--ELVPKKAaGTAAGLTGLFGYLGGsVLATALIGIIVDHFGWNGGFIvllASC 400
|
....*....
gi 15227589 492 GLYLVGTVI 500
Cdd:cd17345 401 ILAIIFLAL 409
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-501 |
1.86e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 62.72 E-value: 1.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 109 CFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPV 188
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 189 AAKlgLPYLLVVRAFMGVGEGVAMPAMNNIL-SKWVPVQERSRSLALVYSGMylGSVTGLAFSPFLIHQFGWPSVFYSfG 267
Cdd:cd17333 81 TPS--IYLFVVLMFLAGLGAGILDTGANTFVgALFEESSATRLNVLHGFFGL--GALIGPLIATSLLTSELSWSWAYL-I 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 268 SLGTVWLTLWLTKAESSPLEDPTLLPEERKLIADNCASKEpvksipwrliLSKPPVWALISCHFCHNWGTFILLTWMPTY 347
Cdd:cd17333 156 IGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRL----------LRNPSIILGALALFLYVGAETAFSSWVPSY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 348 YHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGFSVtnvrkimqTIGFLGPAFFLTQLKHIDSPTMAVLCMA 427
Cdd:cd17333 226 LVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLV--------LSGSGALLGLLILLLAPTLVVGLVATAL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15227589 428 CSqgtdaFSQSGLY----SNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIW 501
Cdd:cd17333 298 LG-----LFMAALFptilSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLA 370
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
126-483 |
1.20e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.90 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 126 AILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMG 205
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS--SIEQLLIARFLQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 206 VGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTV-WLTLWLTKAESS 284
Cdd:cd17320 99 LGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLlLLLVLLFLPETL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 285 PLEDPTLLPeeRKLIADncaskepvksipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSV 364
Cdd:cd17320 179 PEEKRKPLL--SSLLRA------------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 365 FPWMTMAISANAGGWIAdtlvsRGFSVTNVRKIMQTIGFLGPAFFL--TQLKHIDSPTMAVLCMACsqgtdAFSQSGLYS 442
Cdd:cd17320 245 LNAIALILGSLLNGRLV-----RRFGPRRLLRLGLLLLLAAALVLLlaALLGGLSLWPLVAPLFLI-----FFGFGLIFP 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 15227589 443 NHQDIA----PRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSW 483
Cdd:cd17320 315 NATSLAlepfPHVAGTASALLGFLQFLIGALAGALVGLLPNGTAL 359
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
95-280 |
5.68e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.01 E-value: 5.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 95 WWEEFPKRWVIVLLCFSAFLLCNMdrvnMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGF 174
Cdd:cd06173 204 LRRSPLLRLLLLALALFALLGGAL----TVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLI 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 175 GVIWWSIATILTPVAAKLGLpyLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLI 254
Cdd:cd06173 280 GALLLGLALLVLGLSPSLWL--LLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA 357
|
170 180
....*....|....*....|....*.
gi 15227589 255 HQFGWPSVFYSFGSLGTVWLTLWLTK 280
Cdd:cd06173 358 DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
126-500 |
2.84e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 55.64 E-value: 2.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 126 AILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVRAFM 204
Cdd:cd17478 17 ALLPlLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWL--LLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 205 GVGEGVAMP---AMNNILSKwvpvQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKA 281
Cdd:cd17478 95 GIGSAAFHPegaRLASQAAG----GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 282 ESSPLEDPTllpeerkliADNCASKEPVKSIPWRLILskpPVWALIschFCHNWGTFILLTWMPTYYHQVLKFNLMESGL 361
Cdd:cd17478 171 PLKKPEAKK---------AAAKSSARSTLKGVWRALL---LLLIIV---FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 362 LSVFpWMTMAISANAGGWIADTLvsrGfsvtnvRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGT-DAFSQSGL 440
Cdd:cd17478 236 LSLF-LFAGAIGTLIGGPLSDRF---G------RRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLfASFPVTVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 441 YSnhQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVI 500
Cdd:cd17478 306 LA--QELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
133-481 |
3.44e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.68 E-value: 3.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 133 EYGWNPATVGLIQS-SFFWGyLLTQIAGGIWAD---TVGGKR--VLGFGVIWWSIATILTPVAAKLG----LPYLLVVRA 202
Cdd:COG2211 40 VLGLSAALVGLILLvARLWD-AITDPLIGALSDrtrTRWGRRrpWILIGAIPLALSFVLLFTAPDLSptgkLIYALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 203 FMGVGEGVAMPAMNNILSKWVP-VQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFG--------WPSVFYSFGSLGTVW 273
Cdd:COG2211 119 LLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgyrLTALIFAVLGLLAFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 274 LTLWLTKaesspledptllpeERKLIAdncASKEPVKSIpWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLK 353
Cdd:COG2211 199 LTFFGTK--------------ERPVPE---EEKVSLKES-LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 354 FNLMESGLLSVFPWMTMAISANAGGWIADTL-VSRGFSVTNvrkIMQTIGFLGPAFFltqlkHIDSPTMAVLCMACSQGT 432
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKKAFIIGL---LLAALGLLLLFFL-----GPGNLWLLLVLAALAGIG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 15227589 433 DAFSQSGLYSNHQDIAP--------RYSGVLLGLSNTAGVLAGVLGTAATGHILQHG 481
Cdd:COG2211 333 LGAILVLPWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
103-279 |
6.70e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.49 E-value: 6.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 103 WVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVG--GKRVLGFGVIWWS 180
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 181 IATILTPVAAKLGLPYLLVvrAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWP 260
Cdd:COG2271 260 LALLLLALLPSPALAIALL--FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170
....*....|....*....
gi 15227589 261 SVFYSFGSLGTVWLTLWLT 279
Cdd:COG2271 338 AAFLLLAALALLAALLALL 356
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
124-500 |
7.12e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 54.54 E-value: 7.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 124 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYlLVVRAF 203
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF-LGYGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 204 MGVGEGVAMPAMNNILSKWVPvqERsRSLA--LVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKA 281
Cdd:cd17353 102 GGIGAGIGYITPVSTAVKWFP--DK-RGLAtgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 282 ESSPledPTLLPEERKLIADNCASKEPVKSipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLME--- 358
Cdd:cd17353 179 RDPP---KGWVPPGVDPLANNAENSPRDYT--PREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIaal 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 359 -SGLLSVFpwmtmaisaNAG-----GWIADTLvSRgfsvtnvRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSqgt 432
Cdd:cd17353 254 aVSILSIF---------NGGgrpfwGWLSDKI-GR-------KNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALI--- 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227589 433 dAFSQSGLYS-----NHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVI 500
Cdd:cd17353 314 -GFCYGGGFAlfpalTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
103-269 |
7.18e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.51 E-value: 7.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 103 WVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIA-GGIWADTVGGKRVLGFGVIWWSI 181
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 182 ATILTPVAAKLGLPYLLVvrAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLiHQFGWPS 261
Cdd:cd17330 254 GLLLLPFASSVPLLVLAA--AILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL-YSFLGPG 330
|
....*...
gi 15227589 262 VFYSFGSL 269
Cdd:cd17330 331 VPFLLAAG 338
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
102-500 |
1.22e-07 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 53.95 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 102 RWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSI 181
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 182 ATILTPVAAKlGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPvQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPS 261
Cdd:cd17314 81 GYTYLSYVFN-SFPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 262 VfysFGSLGTVWLTLWLTKAESSPLEDPtllpeerkliaDNCASKEPVK-SIPWRLILSKPPV-WALISCHFCHNWGTFI 339
Cdd:cd17314 159 V---YTILGILAAIVLSVVSLLGFKEPP-----------DNQARLHVQKkKTQTMGEIFRDKVfWILFIAIFLVLIGGFL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 340 LLTWMPTYyhqVLKFNLMESG----LLSVFPWMTmAISANAGGWIADTLVSRgfsvTNVRKIMQTIGFLGPAFFLTQLKH 415
Cdd:cd17314 225 FIANMASL---VRSLQLDAPSfvtkLMSIYGLFN-AFGRLLWGIVADFFGGR----LSTLSILLTILGLGLCAFLFLLKM 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 416 IDSPTMAVLCMAcsqgtdAFSQSGLYSNHQDIAP-----RYSGVLLGLSNTAGVLAGVLGTAATGHI-LQHGSWDDVFTI 489
Cdd:cd17314 297 TPVGLVLTGSLL------GFSYGGLFTVYPATVStvfgtESFATLYGILLFAPAIGSILGPMLGAKFyDRTPSYISAVYI 370
|
410
....*....|.
gi 15227589 490 SVGLYLVGTVI 500
Cdd:cd17314 371 YAVIVFLASAI 381
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
160-505 |
2.72e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 2.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 160 GIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGM 239
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGVAGLFLD--SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 240 YLGSVTGLAFSPFLIhQFGWPSVFYSFGSLGTVWLTLWLtkaesspledptLLPE-ERKLIADNCASKEPVKSIPWRlil 318
Cdd:cd17473 134 SLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLL------------FLPEpARKSKSAASPGAATAAALPWK--- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 319 skpPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtNVRKIM 398
Cdd:cd17473 198 ---RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL--------GKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 399 qTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHI 477
Cdd:cd17473 267 -AIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGIVTSAFFLGQFLSPLVLGPL 345
|
330 340
....*....|....*....|....*....
gi 15227589 478 LQ-HGSWDDVFTISVGLYLVGTVIWNLFS 505
Cdd:cd17473 346 VNlTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
127-285 |
4.91e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 51.92 E-value: 4.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 127 ILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGViwWSIATILTPVAAKLGLPYLLVVRAFMG 205
Cdd:cd06180 21 LLPlMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGL--LLTVLLLAAMALTSGFAALLALRFLAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 206 VGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGS-VTGLAFSPFLIHQFGWPSVFYSFG---SLGTVWLTLWLTKA 281
Cdd:cd06180 99 AASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIaLSGLLVPAGLGGGLSWRAGWLALAllsAVLLLLSFLLLRRG 178
|
....
gi 15227589 282 ESSP 285
Cdd:cd06180 179 PSAP 182
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
108-276 |
1.36e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 50.34 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 108 LCFSAFLLCNMDRVNMSIAILPM--------SAEYGWNPATVGLIQSSFFwgylltqIAGGIWADTVGGKRVLGFGVIWW 179
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIigdsfgtsPNQLSWLAASYSLTVGTFI-------LIFGRLGDIYGHKKMFVIGSFWF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 180 SIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSK-WVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFG 258
Cdd:cd17476 74 AIWSLIAGFSP--NFIFFIICRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAW 151
|
170
....*....|....*...
gi 15227589 259 WPSVFYSFGSLGTVWLTL 276
Cdd:cd17476 152 WPWIFWFLAILAAIVAVA 169
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
160-269 |
1.81e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.96 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 160 GIWADTVGGKRVLGFGVIWWSIatILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGM 239
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASAL--LYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQ 338
|
90 100 110
....*....|....*....|....*....|
gi 15227589 240 YLGSVTGLAFSPFLIHQFGWPSVFYSFGSL 269
Cdd:cd17391 339 YLGNVAGPLLGSAIAAHFGYRAVFVVTALL 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
151-501 |
3.03e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 49.10 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 151 GYLLTQIAG----GIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQ 226
Cdd:cd17502 38 AYLLTSTAFqpiyGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP--NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 227 ERSRSLALVySGMY-LGSVTGLAFSPFLIHQFGWPSVFY---SFGSLGTVWLtlwltkaesspledptllpeerkliadn 302
Cdd:cd17502 116 ERGKYQGYI-GAVFgIASVAGPLIGGAFTDHLSWRWCFYinlPIGGLALALL---------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 303 caskepvksipwrlilskPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIAD 382
Cdd:cd17502 167 ------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALIS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 383 TLVsrgfsvtNVRKIMQTIGFLGP--AFFLTQLKHIDSPTMAVLCMA---CSQGTdAFSQSGLYSNHQdIAPRYSGVLLG 457
Cdd:cd17502 229 KTG-------RYKPLIVIGTILMSvgAGLLTTLTLDTSKWLLIGYLIllgLGLGI-GFQQPLVAVQNA-VPPADVGVATA 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15227589 458 LSNTAGVLAGVLGTAATghilqhgswdDVFTISVGLYLVGTVIW 501
Cdd:cd17502 300 TNTFFRSLGGTLGVAIT----------DVFLVALALAALAFLLS 333
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
100-254 |
3.06e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.52 E-value: 3.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 100 PKRWVIVLLCFSAFLLCNMdrVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWW 179
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALA--LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15227589 180 SIATILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQER---SRSLALVYSGMYLGSVTGLAFSPFLI 254
Cdd:COG2211 305 ALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
127-505 |
8.78e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.98 E-value: 8.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 127 ILPMSAEY-----GWNPATVGLIqssfFWGYLLT----QIAGGIWADTVGGKRVLGFGVIWWSIATILtpvAAKLGLPYL 197
Cdd:cd17472 15 VLPVLSVYakslpGATPTLIGLA----LGIYGLTqaifQIPFGLLSDRIGRKPVILFGLLLFIAGSLL---AAYATSIYG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 198 LVV-RAFMGVG--EGVAMpAMnniLSKWVPVQERSRSLALVysGMYLGS--VTGLAFSPFLIHQFGWPSVFYSFGSLGTV 272
Cdd:cd17472 88 LILgRALQGSGaiSSVVM-AL---LADLTREENRTKAMALI--GASIGIafAISMVLGPLLAAHLGVSGLFLITAILSLV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 273 -WLTLWLtkaesspledptLLPEERKLIADNCASKEPVKSipwrlILSKPPVWALischfchNWGTFIL-LTWMPTYYhq 350
Cdd:cd17472 162 sLLILLF------------FVPDPPKIVQISEKEKKKLKK-----LLKNKRLLRL-------DFSIFILhFVLMAFFY-- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 351 VLKFNLMESGLLSVFPWMTMaISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAF-FLTQLKHIDSPTMAVLCMACs 429
Cdd:cd17472 216 ILPLLLTQLGGGKGQLWKVY-LPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVgFLLLLFAATSLWLLIIGLII- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 430 qgtdAFSQSGLYSN------HQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLylvgTVIWNL 503
Cdd:cd17472 294 ----FFIGFNLLEAllpslvSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILIL----ALLWLL 365
|
..
gi 15227589 504 FS 505
Cdd:cd17472 366 VS 367
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
83-266 |
9.02e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 9.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 83 VVSDSPSSIVLPWWEEFPKR--WVIVLLCFSAFLLCNMDRVNMSIAilpMSAEYGWNPATVGLIQSSFFWGYLLTQIAGG 160
Cdd:cd17473 178 RKSKSAASPGAATAAALPWKrvLPIYFLAFLAMLLFYVIPIQLPFL---LQERGGGSAALIGLALAIASLAGAIGALLFG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 161 IWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMY 240
Cdd:cd17473 255 RLKRRLGKRRLLAIGFALMALGFLLLALAS--GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFF 332
|
170 180
....*....|....*....|....*.
gi 15227589 241 LGSvtglAFSPFLIHQFGWPSVFYSF 266
Cdd:cd17473 333 LGQ----FLSPLVLGPLVNLTGGLSG 354
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
123-264 |
2.85e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 123 MSIAILP-MSAEYGWNPATVGLIQSSFFW-GYLLTQIAGGiWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVV 200
Cdd:cd17504 14 MLSPALPtIQREFGTSAAAVSWVLTAYLLvGAVSTPILGR-LGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--LIAG 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15227589 201 RAFMGVGEGV---AMPAMNNILSKwvpvqERSRSLALVYSGMY-LGSVTGLAFSPFLIHQFGWPSVFY 264
Cdd:cd17504 91 RALQGIGGAVfplAFALVREEFPP-----ERVPVAQGILSATFgIGAGIGLPLGGWIVQHLGWRWIFW 153
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
130-260 |
4.56e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.68 E-value: 4.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 130 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEG 209
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH--SPWLFAIALVLTGFGGG 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 15227589 210 VAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTG-LAFSPFLIHQFGWP 260
Cdd:cd17329 104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGpLLGGLLLLYSFRLL 155
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
105-211 |
1.04e-04 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 44.49 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 105 IVLLCFSAFLlcnmdRVNMSIAILP--MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIA 182
Cdd:PRK05122 20 IVMFTFISYL-----TIGLPLAVLPgyVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALS 94
|
90 100 110
....*....|....*....|....*....|....*
gi 15227589 183 TILTPVAA------KLGLPYLLVVRAFMGVGEGVA 211
Cdd:PRK05122 95 GLLYLLAGllaawpVLSLLLLLLGRLLLGIGESLA 129
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
125-278 |
1.19e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 125 IAILP--MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRA 202
Cdd:cd17316 197 TTFLPtyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLF 276
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227589 203 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYS-GMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWL 278
Cdd:cd17316 277 ILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNlGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
106-500 |
1.20e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.55 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 106 VLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATIL 185
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 186 tpvAAKLGLPY--LLVVRAFMGVGEGVAMPAMNNIlSKWVPvQERSRSLALVYS--GMYLGSVTGL------AFSPFLIH 255
Cdd:cd17341 81 ---LALAVSSYwgLLVLGFLLGFAGANFASGQPWA-SFWFP-KEKIGGAAGGIAgaGNMGVAVSQLlapliaGAIVFDGG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 256 QFGWPSVFYSFGSLGTVWLTLWLTKAESSPledptllpeerkliaDNCASKEPVKSIPWRlILSKPPVWALiSCHFCHNW 335
Cdd:cd17341 156 FVGWRNAFFVPGILLAIAAVLVLLFGDDLP---------------TGKASALEFLKVQLA-VLKNYRTWIL-SLLYGVTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 336 GTFILLT-WMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSRGfsVTNVRKIMQTIGFLGPAFFLTqLK 414
Cdd:cd17341 219 GSFVGFSnVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRR--RLWWLFIVMTIGAALLSLSLP-TS 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 415 HIDSPTMAVLCMACSQGTDAFSQSgLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQ-HGSWDDVFTISVGL 493
Cdd:cd17341 296 GTNLVLFLALFVALGLGAGAGNGS-VFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALmTGSGVGAFSLFGVL 374
|
....*..
gi 15227589 494 YLVGTVI 500
Cdd:cd17341 375 AVACTLL 381
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
134-285 |
3.11e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 43.11 E-value: 3.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 134 YGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAakLGLPYLLVVRAFMGVGEGVAMP 213
Cdd:cd17362 34 YNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLA--PSYPVLLVGRLIYGVGIGLAMH 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227589 214 AMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAESSP 285
Cdd:cd17362 112 AAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSP 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
326-504 |
6.47e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 6.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 326 LISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtNVRKIMQTIGFLG 405
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--------GRRRVLLIGLLLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 406 PAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDD 485
Cdd:pfam07690 73 ALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170
....*....|....*....
gi 15227589 486 VFTISVGLYLVGTVIWNLF 504
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLP 171
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
121-273 |
1.08e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 41.49 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 121 VNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVA----AKLGLPY 196
Cdd:cd17364 21 VTKILGRLYYGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSpgstPLGVMGW 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227589 197 LLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVW 273
Cdd:cd17364 101 LIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYHHADLVW 177
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
95-234 |
1.69e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 40.80 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 95 WWEEFPKRWVIVLLCFSAFLLCnmdRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGF 174
Cdd:PRK09556 23 WFKPFMQSYLVVFIGYLTMYLI---RKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPF 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227589 175 GVIWWSIATI---LTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLAL 234
Cdd:PRK09556 100 LLILSAICMLgfgASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGF 162
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
123-258 |
2.78e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 123 MSIAILPMSAEY-GWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAakLGLPYLLVVR 201
Cdd:cd17477 14 LLLPLLSLRLEReGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT--DSPWVWFLLR 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15227589 202 AFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGlafsPFLIHQFG 258
Cdd:cd17477 92 FVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG----PLLLALVG 144
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
103-255 |
2.83e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 103 WVIVLLCFSAFLLCNMDRVNMSIAILPMSAEY--------------GWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGG 168
Cdd:cd17321 154 LINVPIGLVALLLARTFSGAVLAAFLLGAALGgllfllplylqgvlGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 169 KRVLGFGVIWWSIAT-ILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGL 247
Cdd:cd17321 234 RLVLVAGLLLTAVGLlLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGV 313
|
....*...
gi 15227589 248 AFSPFLIH 255
Cdd:cd17321 314 ALLGALLT 321
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
102-504 |
3.58e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 39.63 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 102 RWVIVLLCFSAFLLCNMDRVNMSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSI 181
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 182 ATILtpVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPS 261
Cdd:cd17343 81 TTVA--FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 262 VFYSFG--SLGTVWLTLWLTKAESSPLEDPTLLPEERKliadNCASKEPVKSIPWRLILSKPPVWaLISCHFChnwGTFI 339
Cdd:cd17343 159 TLSISGtvAVVMSVVCLLFIKNEPSDVGLNNIEEEESK----GKKKKSPRGESTLKELLLSPFLW-LLSLGYL---VVFG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 340 LLTWMPTYYHQVLKFNLMESGLLSvfpwmTMAISAN---------AGGWIADTLVSRGFSVT--NVRKIMQTIGFLGPA- 407
Cdd:cd17343 231 VKTAVTDWGQLFLIQDKGQSALTG-----SSFMSSLevggfvgsiAAGYLSDWAVAKHGSSSrgNPRMPLALVFMAGLTv 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 408 --FFLTQLKHIDSPTMAVLCMACSQGTDA---FSQSGLYSNhQDIAPRYSG----VLLGLSNTAGVLAGVlgtaATGHIL 478
Cdd:cd17343 306 slHLFRVHITSDSSELFILLLGFLIGFSLygpIAIFGVIAN-ESAPSHLCGtshaIVALAANVGGVLAGL----PFSYIA 380
|
410 420
....*....|....*....|....*.
gi 15227589 479 QHGSWDDVFTISVGLYLVGTVIWNLF 504
Cdd:cd17343 381 KHYDWRTAFLLLEILCAITVVILFLL 406
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
121-274 |
5.82e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.16 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 121 VNMSIAILPMSAEYGWNPATVGL------IQSSFFWGYLLTQIAGGIwadtvGGKRVLGFGVIWWSIATILTPVAAKLGL 194
Cdd:cd17388 224 VPATTWVLFTEDRFDWSPTMVGLslavfgLLHALFQAFVTGPIAKRL-----GEKRAILLGLAADALGFLLLAFATQGWM 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 195 PYLLVVRAFMGvgeGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTG--LAFSPFLIHQFGWPsvfysfgslGTV 272
Cdd:cd17388 299 VFPILILLALG---GIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGplLFTGIFAASPATWP---------GLA 366
|
..
gi 15227589 273 WL 274
Cdd:cd17388 367 WI 368
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
124-264 |
6.66e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 38.90 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 124 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVRAF 203
Cdd:TIGR00711 22 NVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLEL--MIIFRVI 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227589 204 MGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFY 264
Cdd:TIGR00711 100 QGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
123-259 |
7.39e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 38.67 E-value: 7.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 123 MSIAILPMSAEYGWNPAT--VGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKlgLPYLLVV 200
Cdd:cd17372 16 MLLSFVGPAVQCEWNLSAwqVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPN--YMWLIIL 93
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90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15227589 201 RAFMGVGEGvAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGW 259
Cdd:cd17372 94 RCLVGLGLG-GGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGW 151
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| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
138-296 |
7.93e-03 |
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Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 38.96 E-value: 7.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 138 PATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGL--PYLLVVRAF-MGVGEGVAMPA 214
Cdd:pfam05977 44 PLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLlsPWLLLGLTFlGGIGTALMDPA 123
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227589 215 MNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGwPSVFYSFGSLG--TVWLTLWLTKAESSpledPTLL 292
Cdd:pfam05977 124 WQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFG-PAFTFALNALSyfAVIAALWRWKRAAP----ASPL 198
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....
gi 15227589 293 PEER 296
Cdd:pfam05977 199 PRER 202
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