|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
27-457 |
0e+00 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 514.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 27 EVEKQLLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTGFTFLMGTASAMDTVCGQSYGAKMYGMLG 106
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 107 IQMQRAMLVLTLLSVPLSIVWANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGV 186
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 187 TTSLHVIICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFSKEARRDIIPFMKLVIPSAFMVCsL 266
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLC-L 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 267 EMWSFELLVLSSGLLPnPVLETS----CPRT---VWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESILV 339
Cdd:cd13132 240 EWWAFEILVLLAGLLP-GTVALAaqsiCLTTtslLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 340 GTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLLLGFH 419
Cdd:cd13132 319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398
|
410 420 430
....*....|....*....|....*....|....*...
gi 240254581 420 FHVGGRGLWLGIICALIVQGVCLSLITFFTNWDEEVKK 457
Cdd:cd13132 399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
37-372 |
5.98e-95 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 290.69 E-value: 5.98e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 37 PLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIAtSFASVTGFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQRAMLVL 116
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 117 TLLSVPLSIVWANTEHFLVFFGQ-DKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHVIIC 195
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 196 WVLVLK--SGLGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFSKEARRDIIPFMKLVIPSAFMVCSLEMWS--F 271
Cdd:TIGR00797 160 YILIFGkfGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFalL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 272 ELLVLSSG--LLPNPVLETSCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESILVGTVLILIRKI 349
Cdd:TIGR00797 240 ALLVARLGsiALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330 340
....*....|....*....|...
gi 240254581 350 WGFAYSSDPEVVSHVASMLPILA 372
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
30-444 |
7.99e-61 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 205.04 E-value: 7.99e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 30 KQLL-LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYGAKMYGMLGIQ 108
Cdd:cd13131 3 RALLrLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIRRA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 109 MQRAMLVLTLLSVPLSIVWANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTT 188
Cdd:cd13131 82 VRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 189 SLHVIICWVLVL-KSG---LGFRGAAVANAISYWLNVILLSCYVKFSP--SCSLTWTGFSKEARRDIIPFMKLVIPSAFM 262
Cdd:cd13131 162 VLNIPLNYVLIFgKFGlpaLGGAGAGLATAIVYWLMFLALAFYIRRHKrfRRYRLFARFWRPDWARLKELLRLGLPIGLT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 263 VCsLEMWSFELLVLSSGLLPNPVLE-----TSCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESI 337
Cdd:cd13131 242 IF-FEVSLFAAVALLMGRLGTTVLAahqiaLNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 338 LVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLLLG 417
Cdd:cd13131 321 LTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLLA 400
|
410 420
....*....|....*....|....*..
gi 240254581 418 FHFHVGGRGLWLGIICALIVQGVCLSL 444
Cdd:cd13131 401 FTTGLGAFGVWIGLIIGLALAAILLLW 427
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
23-442 |
9.18e-59 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 199.60 E-value: 9.18e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 23 FVKEEVEKQLL-LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYGAKM 101
Cdd:COG0534 1 LTEGPILKLLLrLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 102 YGMLGIQMQRAMLVLTLLSVPLSIV-WANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPV 180
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 181 VICSGVTTSLHVIICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFSKEARRDIIPFMKLVIPSA 260
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 261 FMVcSLEMWSFELLVLSSGLLPNPVL---------ETscprTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSF 331
Cdd:COG0534 240 LQQ-LAESLGFLVLNALVARLGTAAVaaygialriES----LAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 332 SIVESILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVP 411
Cdd:COG0534 315 ALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLP 394
|
410 420 430
....*....|....*....|....*....|.
gi 240254581 412 FGLLLGFHFHvGGRGLWLGIICALIVQGVCL 442
Cdd:COG0534 395 LAYLLAFLGL-GLTGVWLALPIGEVLRALLL 424
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
32-451 |
3.70e-43 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 157.67 E-value: 3.70e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 32 LLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQR 111
Cdd:cd13137 4 WSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRALGQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 112 AMLVLTLLSVPLSIV-WANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSL 190
Cdd:cd13137 83 SLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 191 HVIICWVLVLKS----GLGFRGAAVANAISY-----WLNVILLScyVKFSPSCSLTWTGFSKEARRDIIpfmKLVIPSAF 261
Cdd:cd13137 163 NIVLDYVLIFGLwgfpGLGVAGAALATVISRvvgalLLLFLLLR--GRLPIKISFKGFRLDRKIIKKLL---RIGLPAGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 262 MvcSLEMWSFELLVLS-SGLLPNPVLET-SCPRTVW----MIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVE 335
Cdd:cd13137 238 E--QLLRSLGFLVLLAiVASYGTAALAAyQIGLRIEslafMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 336 SILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLL 415
Cdd:cd13137 316 MGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYL 395
|
410 420 430
....*....|....*....|....*....|....*.
gi 240254581 416 LGFHFHVGGRGLWLGIICALIVQGVCLSLITFFTNW 451
Cdd:cd13137 396 LGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
37-197 |
8.96e-36 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 129.99 E-value: 8.96e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 37 PLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQRAMLVL 116
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 117 TLLSVPLSIV-WANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHVIIC 195
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 240254581 196 WV 197
Cdd:pfam01554 160 YL 161
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
35-448 |
4.10e-31 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 124.36 E-value: 4.10e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 35 SGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASvTGFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQRAML 114
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 115 VLTLLSVPLSIV-WANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHVI 193
Cdd:cd12082 80 LAILLGLLLAALlLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 194 ICWVLV---LKSGLGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFSKEARRDIIPFMKLVIPSAFMVCSLEMWS 270
Cdd:cd12082 160 LDPLLIfglGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 271 FELLVLSSGLLPNPVLE-----TSCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESILVGTVLIL 345
Cdd:cd12082 240 LIIVAIVAAFGGAAALAaytvaFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 346 IRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLLLGFHfHVGGR 425
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYL-GLGLY 398
|
410 420
....*....|....*....|...
gi 240254581 426 GLWLGIICALIVQGvCLSLITFF 448
Cdd:cd12082 399 GIWLALVISLILAA-LVLLLFFR 420
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
25-444 |
8.06e-29 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 118.38 E-value: 8.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 25 KEEVEKQLLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFAsVTGFTFLMGTASAMDTVCGQSYGAKMYGM 104
Cdd:PRK01766 8 KSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 105 LGIQMQRAMLVLTLLSVPLSIVWANTEH-FLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVIC 183
Cdd:PRK01766 87 IAHQVRQGLWLALFLSVLIMLVLYNAVPpILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 184 SGVTTSLHVIICWVLVL-KSG---LGFRGAAVANAISYWLNVILLSCYVKFSPS--CSLTWTGFSKEARRDIIPFMKLVI 257
Cdd:PRK01766 167 GFLGLLINIPLNYIFIYgKFGfpeLGGVGCGVATAIVYWVMFLAMLIYIKRARRfrDFRLFKGLYKPDWAVIKRLLKLGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 258 PSAFMVCslemwsFE--------LLVlsSGLLPNPV------LETScpRTVWMIPFGLSGAASTRVSNELGSGNPKGAKL 323
Cdd:PRK01766 247 PIGLAIF------FEvslfavvtLLV--SPLGTVTVaahqiaLNFS--SLLFMLPLSLAMALTIRVGFELGAGRTLDARQ 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 324 AVRVVLSFSIVESILVGTVLILIRKIWGFAYSSDPEVVsHVASMLPILALGHSL-DSFQTVLSGVARGCGWQKIGAFVNL 402
Cdd:PRK01766 317 YAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVV-ALASHLLLFAALFQFsDAIQVIGSGALRGYKDTRVIFFITF 395
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 240254581 403 GSYYLVGVPFGLLLGFHFHVGGRGLWLGIICALIVQGVCLSL 444
Cdd:PRK01766 396 IAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-433 |
1.70e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 108.36 E-value: 1.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 34 LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVtGFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQRAM 113
Cdd:cd13134 8 LAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQIAGVAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 114 LVLTLLSVPLSIVWANT-EHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHV 192
Cdd:cd13134 87 LFNLLLGLVFSLLLLFFgAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 193 IICWVLVLKSG----LGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFSKEARRDIIPFMKLVIPSAfmvcsLEM 268
Cdd:cd13134 167 VGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSA-----GEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 269 --WSFELLVLSS--GLLPNPVLETscpRT--------VWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVES 336
Cdd:cd13134 242 lsYNLSQTVITAfiARLGTAALAA---RTyasnismfVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 337 ILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLLL 416
Cdd:cd13134 319 LAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLL 398
|
410
....*....|....*..
gi 240254581 417 GFHFHVGGRGLWLGIIC 433
Cdd:cd13134 399 GIVLGLGLLGVWIAFAA 415
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
32-451 |
1.09e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 106.07 E-value: 1.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 32 LLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIAtSFASVTGFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQR 111
Cdd:cd13133 8 LKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 112 AMLVLTLLSVPLSIVWA-NTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSL 190
Cdd:cd13133 87 GLYFSLLLAPLLALLSAlAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 191 HVIICWVLVLKSG----LGFRGAAVANAISYWLNVILLSCYVkFSPS-----CSLTWTGFSKEARRDIipfMKLVIPSAF 261
Cdd:cd13133 167 NIVLDYALIFGKLgfpaMGIAGAAIATVIAEAVSLLFFLLLL-FRRKnrrrfGLRRAWRFDRELLRRI---LRLGLPSGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 262 MVCsLEMWSFELLVLSSGLL-PNPVLETSCPRTVWMIPF----GLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVES 336
Cdd:cd13133 243 QFF-LDVGAFTVFFLLIGRLgTTELAATNIVFSINSLAFlpmiGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYM 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 337 ILVGTVLILIRKIW--GFAYSSDPEVVSHVAS-MLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFG 413
Cdd:cd13133 322 LLLGILFLLFPELLlsIFTPGADFALIAELAVpLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPA 401
|
410 420 430
....*....|....*....|....*....|....*...
gi 240254581 414 LLLGFhFHVGGRGLWLGIICALIVQGVCLSLITFFTNW 451
Cdd:cd13133 402 YLLVV-LGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-451 |
7.23e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 100.73 E-value: 7.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 20 RSRFVKEEVEKQLL-LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIatSFASV-TGFTFLMGTASAMDTVCGQSY 97
Cdd:cd13142 1 RENILEGSILRTLLkLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSI--SWPLIfLFISLGGGLTVAGTALVAQYT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 98 GAKMYGMLGIQMQRAMLVLTLLSVPLSIV--WANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQN 175
Cdd:cd13142 79 GAGDYDKANKVAGQTFSFVIILSLILAVLgyILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 176 NVIPVVICSGVTTSLHVIICWVLVLK----SGLGFRGAAVANAIS-----YWLNVILLSCYVKFSPScsltwtgfskeaR 246
Cdd:cd13142 159 DTKTPMKIMFGSVLLNVILDPLLIFGigpfPGLGVAGAALATVISrgiaaVIGLYLLFKGRVGLKIS------------L 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 247 RDIIPFMKLV-------IPS---------AFMVCSLEMWSFELLVLSSGLLPNPVLETscprtVWMIPFGLSGAASTRVS 310
Cdd:cd13142 227 RDLKPDWEWLkkifrigLPSsieqsaralGFTVMTALVAGFGTVVVAAYGIGNRIISL-----VFLPAFGLARATSTMVG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 311 NELGSGNPKGAKLAVRV--VLSFSIVesILVGTVLILIRK-IWGFaYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGV 387
Cdd:cd13142 302 QNLGAGQIDRAEEIVKKaaLLIFLIL--VIGGVLAFLFAEpIVRV-FINDPEVIKEGADFLRIVAPSFPFFGLFQVINGA 378
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 240254581 388 ARGCGWQKIGAFVNLGSYYLVGVPFGLLLGFHFHVGGRGLWLGIICALIVQGVCLSLITFFTNW 451
Cdd:cd13142 379 FRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTW 442
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
32-447 |
1.68e-22 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 99.51 E-value: 1.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 32 LLLSGPLIAVSLLQFCLQIISVMFVGHL-GSLPLSAASIATSFAS-VTGFTFLMGTASAmdTVCGQSYGAKMYGMLGIQM 109
Cdd:cd13143 7 LKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKANRIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 110 QRAMLVLTLLSVPLSIV-WANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTT 188
Cdd:cd13143 85 STALLLSLILGLLLTILgLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 189 SLHVIICWVLVLKSGLGFRGAAVANAISYWLN-VILLSCYVKFSPSCSLTWtGFSKEARRDIIPFMKLVIPSAFM----- 262
Cdd:cd13143 165 VLNIILDPLFIFVLGLGIAGAALATVIAQLISlLLLLLYFFRGKSLLKLSL-LRFKLSLKIIKEILALGFPSFLMqlsss 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 263 ----VCSLEMWSF--ELLVLSSGLLpnpvleTSCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVES 336
Cdd:cd13143 244 vvtiVLNLTLLGYggDIGVAAFGIV------TRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 337 ILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLLL 416
Cdd:cd13143 318 LVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLIL 397
|
410 420 430
....*....|....*....|....*....|.
gi 240254581 417 GFHFhvGGRGLWLgiicALIVQGVCLSLITF 447
Cdd:cd13143 398 PRLF--GLDGIWL----AFPLAEILTLLLAL 422
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
32-451 |
3.81e-22 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 98.30 E-value: 3.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 32 LLLSGPLIAVSLLQFCLQIISVMFVGH-LGSLPLSAASIATSFAS-VTGFtfLMGTASAMDTVCGQSYGAKMYGMLGIQM 109
Cdd:cd13138 6 LLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFlLTAI--GMGLSMGGTILISQYIGAKDEEKAKKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 110 QRAMLVLTLLSVPLSIV-WANTEHFLVFFGQDKSIAHLSGSYAR---FMIPSIFAYGLLQCLnrfLQAQNNVIPVVICSG 185
Cdd:cd13138 84 GTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLRicfLGIPFIFGYNAYSAI---LRGLGDSKTPLYFVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 186 VTTSLHVIICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVKF-SPSCSLTWTGFSKEaRRDIIPFMKLVIPSAFMvc 264
Cdd:cd13138 161 IACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKkKLPFKLSLKDFRFD-KEILKEILKIGLPSALQ-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 265 slemwsfELLVLSSGLLPNPVLETSCPRTV-------------WMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSF 331
Cdd:cd13138 238 -------QSLVSISFLIINSIVNSYGVVASaaygiankinsfaFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIII 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 332 SIVESILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVP 411
Cdd:cd13138 311 SLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIP 390
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 240254581 412 FGLLLGFHFHVGGRGLWLGIICALIVQGVCLSLITFFTNW 451
Cdd:cd13138 391 LAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
32-444 |
5.90e-19 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 89.03 E-value: 5.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 32 LLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASI-ATSFASVTgfTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQ 110
Cdd:PRK00187 13 LRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLgAASYSFVS--IFCVGVIAAVGTLVAIRHGAGDIEGATRLAQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 111 RAMLVLTLLSVPLSIVWANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSL 190
Cdd:PRK00187 91 AGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAGAVA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 191 HVIICWVLVLK----SGLGFRGAAVANAISYWLNVILLSCYVKFSPSCSL--TWTGFSKEARRDIIPFMKLVIP--SAFM 262
Cdd:PRK00187 171 NLLLNYALIEGwfglPKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAypLRKGLSRPSRAALRELWRLGLPigGTYA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 263 VcslEMWSFELLVLSSGLLPNPVLET-----SCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESI 337
Cdd:PRK00187 251 V---EVGLFTFAALCMGALGSTQLAAhqialQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVML 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 338 LVGTVLILIRK--IWGFAYSSDP---EVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPF 412
Cdd:PRK00187 328 LFAGLFWLLPEaiIGLFLDRNDPafaEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPL 407
|
410 420 430
....*....|....*....|....*....|..
gi 240254581 413 GLLLGFHFHVGGRGLWLGIICALIVQGVCLSL 444
Cdd:PRK00187 408 AWLLAFTLGWGAVGVWWGLALGLACAAVALTL 439
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
258-415 |
1.29e-17 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 79.92 E-value: 1.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 258 PSAFMVCSLEMWSFELLVLSSGLLPNPV----LETSCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSI 333
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALaavsIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 334 VESILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSyYLVGVPFG 413
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
..
gi 240254581 414 LL 415
Cdd:pfam01554 160 YL 161
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
32-445 |
2.72e-17 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 83.76 E-value: 2.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 32 LLLSGPLIAVSLLQFCLQIISVMFVGHLGSL-PLSAASIATSFASV--TGFTFL-MGTASAMdtvcGQSYGAKMYGMLGI 107
Cdd:cd13136 6 LALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTlfWLFGFLrMGTTGLV----AQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 108 QMQRAM-------LVLTLLSVPLsivwanTEHFLVFFGQDKSIAHLSGSYARFMIPSI-FAYGLLQCLNRFLQAQNNVIP 179
Cdd:cd13136 82 LLVRALllalaigLLLILLQSPL------LALALLLLGASAAVAALARQYLRIRILGApAVLLNYVATGWFRGLQDTRTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 180 VVIcSGVTTSLHVIICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFSKEARRDIIPFMKLVIPs 259
Cdd:cd13136 156 LIL-QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRD- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 260 aFMVCSLEMWSFELLVLSSG-------LLPNPVLetscpRTVWMIP----FGLSGAASTRVSNELGSGNPKGAKLAVRVV 328
Cdd:cd13136 234 -IFIRTLALLAAFLFFTALAarlgdviLAANQIL-----LQFWLLSsyflDGFAYAAEALVGRALGAGDRKAARRVARRL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 329 LSFSIVESILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSyylV 408
Cdd:cd13136 308 LQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVS---L 384
|
410 420 430
....*....|....*....|....*....|....*..
gi 240254581 409 GVPFGLLLGFHFHVGGRGLWLGIICALIVQGVCLSLI 445
Cdd:cd13136 385 AVFLPLLFLLVPLWGNHGLWLALILFMLLRGLTLALR 421
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
32-447 |
8.22e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 76.50 E-value: 8.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 32 LLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQR 111
Cdd:cd13139 17 FLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFAAVQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 112 AMLVLTLLSVPLSIV-WANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSL 190
Cdd:cd13139 96 AILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 191 HVIICWVLVLKSG----LGFRGAAVANAISYWLNViLLSCYVKFSPSCSLTwtgFSKEARRDIIPFMKLVIPSA------ 260
Cdd:cd13139 176 NIILDPLFIFGLGpipaMGVTGAAIATTIGRSIGV-LYQLYHLFKGKGRIQ---IRRRHLKLDWAIIKKIIKIAvggilq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 261 FMVCSLEMWSFELLVLSSGllpNPVLE--TSCPR--TVWMIP-FGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVE 335
Cdd:cd13139 252 FLIASSSWIFLVRIIAEFG---STALAgyTIAIRiiMFALLPaWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 336 SILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLL 415
Cdd:cd13139 329 LGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYL 408
|
410 420 430
....*....|....*....|....*....|..
gi 240254581 416 LGFHFHVGGRGLWLGIICALIVQGVcLSLITF 447
Cdd:cd13139 409 LARHLNLGPKGVFIAIPIAETVLAI-AAIILF 439
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
19-224 |
1.24e-13 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 72.48 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 19 KRSRFVKEEVEKQLLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYG 98
Cdd:COG0534 219 RDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLG 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 99 AKMYGMLGIQMQRAMLVLTLLSVPLSIV-WANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNV 177
Cdd:COG0534 298 AGDYDRARRAARLALLLALGIGLLLALLlFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDT 377
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 240254581 178 IPVVICSGVTTSLHVIICWVLVLKSGLGFRGAAVANAISYWLNVILL 224
Cdd:COG0534 378 RFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLL 424
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-444 |
1.76e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 71.94 E-value: 1.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 37 PLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATS-FASVTGFTFLMGTASAMdtVCGQSYGAKMYGMLGIQMQRAMLV 115
Cdd:cd13135 9 PLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTpFNTITGFLGSISIGFTI--LGSQSVGAKDIKRINDYAISSIVY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 116 LTLLSVPLSIVWANTEHFL-VFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHVII 194
Cdd:cd13135 87 NSIIGVILFLLWLFGARIIfVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 195 CWVLVL-KSG---LGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFsKEARRDIIPF---MKLVIPSAFMvcsle 267
Cdd:cd13135 167 DYVLIFgNFGfprLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNT-KVLKANIRPYkftIKLGLPLGGE----- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 268 mwsfELLVLSSGLLPNPVLET-------------SCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIV 334
Cdd:cd13135 241 ----EFLWNIGNLAVIRILNRigelalgiytlvfGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 335 ESILVGTVLILI-RKIWGFaYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVgVPFG 413
Cdd:cd13135 317 IYIAAAIVFLAFpYKILSL-FTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTIIV-VSVA 394
|
410 420 430
....*....|....*....|....*....|.
gi 240254581 414 LLLGFHFHVGGRGLWLGIICALIVQGVCLSL 444
Cdd:cd13135 395 LLLIFVFKLGLAGVYITLFIDEIIRAIINFL 425
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
30-451 |
2.81e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 71.40 E-value: 2.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 30 KQLL-LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIAtsfasvtGFTFLMGTASAMDTVCG------QSYGAK-- 100
Cdd:cd13140 5 KTLLrLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTA-------GFFVWLAYALALLSKIGaqvkvsQSIGAKde 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 101 ----MYGMLGIQMQramLVLTLLSVPLSIVWANTehFLVFFG-QDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQN 175
Cdd:cd13140 78 kearKYARNALQLN---LLLGILYGLLLLLFAKP--LIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 176 NVIPVVICSGVTTSLHVIICWVLVLKSG----LGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFSKEARRDIIP 251
Cdd:cd13140 153 DSKTPFIINAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 252 FMKLVIPSAFMVCSLEMWSFELLVLSSGLLPNPV--------LEtSCPrtvWMIPFGLSGAASTRVSNELGSGNPKGAKL 323
Cdd:cd13140 233 ILKLGLPVALQSILFALISMILARIIASFGPVAIaaqkvgsqIE-SIS---WMTAEGFSTALAAFVGQNYGAGKYDRIRK 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 324 AVRVVLSFSIVESILVGTVLILIRK-IWGFaYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNL 402
Cdd:cd13140 309 GYKTALKIASAIGLFATLLLFFFGEpLFSL-FIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISI 387
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 240254581 403 GSYYLvGVPFGLLLGfHFHVGGRGLWLGIICALIVQGVCLSLITFFTNW 451
Cdd:cd13140 388 VFNGL-RIPLALLLS-PTGLGLNGIWWAISISSILKGIILTIWFLLYKK 434
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
22-439 |
4.00e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 58.47 E-value: 4.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 22 RFVKEEVEKQLL-LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIAtsFASVTGFTFL-MGTASAMDTVCGQSYGA 99
Cdd:cd13149 1 KLTEGSIPRHLIkLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFT--FPVVLFLNSLtIGLGIGASAVISRAIGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 100 KMYGMLGIQMQRAMLVLTLLSVPLSIVWANTEHFLVF-FGQDKSIAHLSGSYARF-MIPSIFAYGLLQCLNRFLQAQNNV 177
Cdd:cd13149 79 GDRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSlLGASGEILPLIVEYMAIwYLGLVFLVLPMVGNAIIRATGDTK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 178 IPVVI---CSGVTTSLHVIICWVLVLKSGLGFRGAAVANAISyWLNVILLSCYVKFSPSCSLTWTGFS-KEARRDIIPFM 253
Cdd:cd13149 159 RPSLVmlgAALVNVILDPILIFGFGPIPGMGIAGAAIATVIS-RALGLGAALYFLHYHHRLIDFSEPSlKALFRSWKDIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 254 KLVIPSAFMVCSLEMWSFELLVLSSGLLPNPV----LETSCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVL 329
Cdd:cd13149 238 SIGIPAALSNILTPLSAAFITALVATYGPAAVaafgVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 330 SFSIVESILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVG 409
Cdd:cd13149 318 KFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLY 397
|
410 420 430
....*....|....*....|....*....|
gi 240254581 410 VPFGlLLGFHFHvGGRGLWLGIICALIVQG 439
Cdd:cd13149 398 IPLA-YVGSHLL-GFAGVFIGALAGNLIAG 425
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
19-230 |
5.99e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 54.77 E-value: 5.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 19 KRSRFVKEEVEKQLLLSGPliavSLLQFCLQIISVMF----VGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCG 94
Cdd:cd13138 215 KDFRFDKEILKEILKIGLP----SALQQSLVSISFLIinsiVNSYGVVASAAYGIANKINSFA-FLPPSAIGQAVSTFVA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 95 QSYGAKMYGMLGIQMQRAMLVLTLLSVPLS-IVWANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQA 173
Cdd:cd13138 290 QNIGAGKIERAKKGLRTGIIISLIIGLIIIlLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRG 369
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 240254581 174 QNNVIPVVICSGVTTSL-HVIICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVKF 230
Cdd:cd13138 370 LGKTKFPMIISILRLWLvRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRK 427
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
131-437 |
2.27e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 53.17 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 131 EHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHVIICWVLVLKSGLGFRGAA 210
Cdd:cd13146 113 EPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 211 VANAISYWLNVILLSCYVKFSPS---CSLTWTGFSKEARRDIIP------FMKLVIPSAFMVCSLEMWSFELLVLSSGll 281
Cdd:cd13146 193 LATVLAQAISLLYLLYVFLIGKSnvtIHIKLSNISSSVIVEILRvglpqmLLQLISSISFLIYNRIIIDIDPVAMTAF-- 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 282 pnpVLETSCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESILVGTVLILIRKIWGFAYSSDPEVV 361
Cdd:cd13146 271 ---TLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVV 347
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 240254581 362 SHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLLLGFHFHVGGRGLWLGIICALIV 437
Cdd:cd13146 348 AYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFF 423
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
293-448 |
1.43e-06 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 50.53 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 293 TVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILA 372
Cdd:COG0534 55 LLIALGIGLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIIL 134
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 240254581 373 LGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSyYLVGVPFGLLLGFHFHVGGRGLWLGIICALIVQGVCLSLITFF 448
Cdd:COG0534 135 LGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG-NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFR 209
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
39-224 |
3.56e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 49.05 E-value: 3.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 39 IAVSLLQFCLQIISVMF----VGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQRAML 114
Cdd:cd13143 233 FPSFLMQLSSSVVTIVLnltlLGYGGDIGVAAFGIVTRILTFL-FLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALI 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 115 VLTLLSVPL-SIVWANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHVI 193
Cdd:cd13143 312 VALIYGLVLfLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLI 391
|
170 180 190
....*....|....*....|....*....|....*
gi 240254581 194 ICwVLVLKSGLGFRG----AAVANAISYWLNVILL 224
Cdd:cd13143 392 PL-LLILPRLFGLDGiwlaFPLAEILTLLLALILL 425
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
11-217 |
5.09e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 48.66 E-value: 5.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 11 WPLIGEKEKRSRFVKEEVEKQLLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIAT---SFASVTGFTFLMGTAs 87
Cdd:cd13137 208 RLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLrieSLAFMPGFGFSMAAS- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 88 amdTVCGQSYGAKMYGML---GIQMQR-AMLVLTLLSVplsIVWANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGL 163
Cdd:cd13137 287 ---TLVGQNLGAGDPDEArryGKRALRlGVLFMGLLGL---LLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAI 360
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 240254581 164 LQCLNRFLQ-AQNNVIPVVICSGVTTSLHVIICWVLVLKSGLGFRGAAVANAISY 217
Cdd:cd13137 361 SFVLSGALRgAGDTRPPLIINLISMWLVRLPLAYLLGFVLGLGLTGIWLAMFVDT 415
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
112-305 |
8.19e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 48.22 E-value: 8.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 112 AMLVLTLLSVPLSIVWANTEHFlvffgqDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLH 191
Cdd:COG0728 316 AAVGLIVLAEPIVRLLFERGAF------TAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVN 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 192 VIICWVLVLKsgLGFRGAAVANAISYWLNVILLSCYvkfspscsLTWTGFSKEARRDIIPFMKLVIPSAFMVCslemwsf 271
Cdd:COG0728 390 IVLNLLLVPP--LGHAGLALATSLSALVNALLLLVL--------LRRRLGGLPLRGILRTLLKLLLASLVMGA------- 452
|
170 180 190
....*....|....*....|....*....|....
gi 240254581 272 eLLVLSSGLLPNPVLETSCPRTVWMIPFGLSGAA 305
Cdd:COG0728 453 -VLWLLLRLLGDWLGGGLLGRLLALALLILVGAA 485
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
144-224 |
2.08e-05 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 46.68 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 144 AHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHVIICWVLVLKsgLGFRGAAVANAISYWLNVIL 223
Cdd:cd13123 335 TLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKP--LGHVGLALATSLSAWVNALL 412
|
.
gi 240254581 224 L 224
Cdd:cd13123 413 L 413
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
109-229 |
6.23e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 45.23 E-value: 6.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 109 MQRAMLVLTLLSVPLSIVWANTEHFLV--FFGQDKSiahLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGV 186
Cdd:cd13128 285 LKKSFKYLFLISLPIAIGLFLFAEPIItlLFGEEYL---PAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI 361
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 240254581 187 TTSLHVIICWVLVLKsgLGFRGAAVANAISYWLNVILLSCYVK 229
Cdd:cd13128 362 GALLNVILNLLLIPK--YGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
34-448 |
8.98e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 44.84 E-value: 8.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 34 LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVT---GFTFLMGTASAMdtvcGQSYGAKMYGMLGIQMQ 110
Cdd:cd13147 14 LSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIiglGNGLGAGASSAI----SRRIGAKDKEGADNAAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 111 RAMLVLTLLSVPLSIVW-ANTEHFLVFFGqDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTS 189
Cdd:cd13147 90 HSILLGLIISIILTIVLlPFLEPILVLMG-AGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 190 LHVIICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVKFSPSC--SLTWTGFSKEAR--RDIIpfmKLVIPSA--FMV 263
Cdd:cd13147 169 LNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKDTyvSLSLKNFKFDKKivKDIL---KVGIPASleQLI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 264 CSLEMWSFELLVLSSGLLPNPVLETSCPRTVW--MIP-FGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESILVG 340
Cdd:cd13147 246 MSVLMIILNLILVIVAGTDGVAVYTAGWRIVSfaIIPlIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 341 TVLILIRKI--WGFAYSSD-----PEVVSHVASM---LPILALGhsldsfqTVLSGVARGCGWQKIGAFVNLGSYYLVGV 410
Cdd:cd13147 326 ILIFIFAPQiaYLFTYSEEsahlaPEIVAFLRIMclfLPFVPFG-------MMSSSMFQGIGKGLTSLIITILRELIFQV 398
|
410 420 430
....*....|....*....|....*....|....*...
gi 240254581 411 PFGLLLGFHFHVGGRGLWLGIICAlivqGVCLSLITFF 448
Cdd:cd13147 399 LFAYLFAIVLGLGLFGVWWGIVLG----NAIGSIVGYL 432
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-447 |
1.00e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 44.53 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 34 LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYGAKMYGMlgiqMQRAM 113
Cdd:cd13144 13 MSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKE----ANKAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 114 LVLTLLSVPLSIVWA-----NTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNN----VIPVVICS 184
Cdd:cd13144 88 NNGLLLALLSYLLFLllglfGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNtitpMIAQLIGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 185 GVTTSLHVIICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVKFSP---SCSLTWTGFSKEARRDIipfMKLVIPSAF 261
Cdd:cd13144 168 IINIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNkdvQPDLRLFRPSLRIIKEI---YAVGLPSII 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 262 MVCSLEMWSFELLVLSSGLLPNPVletscprTVWMI-----------PFGLSGAASTRVSNELGSGNPKGAKLAVRVVLS 330
Cdd:cd13144 245 MQAISSVMVFGLNKILAGFGPTAV-------AVFGIyfklqsfvfmpVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAIL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 331 FSIVESILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGV 410
Cdd:cd13144 318 IAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLL 397
|
410 420 430
....*....|....*....|....*....|....*..
gi 240254581 411 PFGLLLGFHFhvGGRGLWLGIICALIVQGVcLSLITF 447
Cdd:cd13144 398 PLAWLLAKMF--GLNGVWWSFPIAEIVSFL-LSLLFL 431
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
35-224 |
2.43e-04 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 43.40 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 35 SGPLIAVSLLQFCLQIISVMFVGHLgsLPLSAA---SIATSFASVTGFtFLMGTASAMDTVCGQSYGAKMYGMLGIQMQR 111
Cdd:COG2244 179 SLPLLLSGLLGLLLTNLDRLLLGAL--LGPAAVgiySAAYRLASLLLL-LITALSQVLFPRLSRLLAEGDREELRRLYRK 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 112 AMLVLTLLSVPLSI-VWANTEHFLVFFGQDKSIAhlSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSL 190
Cdd:COG2244 256 ALRLLLLLGLPLALgLALLAPPLLSLLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVL 333
|
170 180 190
....*....|....*....|....*....|....
gi 240254581 191 HVIICWVLVLKsgLGFRGAAVANAISYWLNVILL 224
Cdd:COG2244 334 NLVLNLLLIPR--YGLVGAAIATLLSYLVLLLLL 365
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-232 |
4.30e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 42.69 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 34 LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATS-FASVTGFTFLMGTASAmdTVCGQSYGAKMYGMLGIQMQRA 112
Cdd:cd13141 16 MALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNvMFFVMALTQVLNVGTA--ALVSHAVGRKDQGEANAVFNQS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 113 MLVLTLLS-VPLSIVWANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLH 191
Cdd:cd13141 94 LLLAAVLGlVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVLLN 173
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 240254581 192 VIICWVLV----LKSGLGFRGAAVANAISYWLNVILLSCYVKFSP 232
Cdd:cd13141 174 IILAPILItgwgTGRALGVAGAGLASSISVAIAVVLLLYYFLRLE 218
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
25-155 |
4.35e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 42.23 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 25 KEEVEKQLLLSGP-LIAVSLLQFCLQIISVmFVGHLGSLPLSAASIATSFASVTgFTFLMGTASAMDTVCGQSYGAKMYG 103
Cdd:TIGR00797 212 WEVLKRLLKLGLPiAFRVILESLSFALLAL-LVARLGSIALAAHQIALNVESLL-FMPAFGFGIAVSILVGQALGAGDPK 289
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 240254581 104 MLGIQMQRA-MLVLTLLSVPLSIVWANTEHFLVFFGQDKSIAHLSGSYARFMI 155
Cdd:TIGR00797 290 RAKEVARVAlKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-229 |
1.44e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 40.74 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 34 LSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVtGFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQRAM 113
Cdd:cd13135 233 LGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENI-VLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 114 LVLTLLSVPLSIVW-ANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHV 192
Cdd:cd13135 312 GLGLLIYIAAAIVFlAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTIIVV 391
|
170 180 190
....*....|....*....|....*....|....*..
gi 240254581 193 IICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVK 229
Cdd:cd13135 392 SVALLLIFVFKLGLAGVYITLFIDEIIRAIINFLKYR 428
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
10-156 |
5.13e-03 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 39.08 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 10 SWPLIGEKEKRSRFVKEEVEKQLLLSGPLIAVSL-LQFCLqIISVMFVGHLGSLPLSAASIATSFASVTGFtFLMGTASA 88
Cdd:cd13136 206 RVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLaLLAAF-LFFTALAARLGDVILAANQILLQFWLLSSY-FLDGFAYA 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 240254581 89 MDTVCGQSYGAKMYGMLgiqmQRAMLVLTLLSVPLS-----IVWANTEHFLVFFGQDKSIAHLSGSYARFMIP 156
Cdd:cd13136 284 AEALVGRALGAGDRKAA----RRVARRLLQWGLGLGvllalLFFLGGEPIIRLFTDDPAVLALAATYLPWLAL 352
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
108-230 |
8.26e-03 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 38.60 E-value: 8.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254581 108 QMQRAMLVLTLLSVPLSI---VWAnTEHFLVFFGQDKSiahlsGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICS 184
Cdd:cd13124 313 RINQALRLTLLIGLPAAVglaVLA-EPINTLLFGDSEG-----GLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINL 386
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 240254581 185 GVTTSLHVIICWVLVlkSGLGFRGAAVANAISY----WLNVILLSCYVKF 230
Cdd:cd13124 387 LIGLLVKIVLNYVLI--PIFGIYGAAIATVIGFlvaaLLNLRALKKLLGF 434
|
|
| |
