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Conserved domains on  [gi|15227373|ref|NP_181681|]
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WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-like protein [Arabidopsis thaliana]

Protein Classification

U4/U6 small nuclear ribonucleoprotein Prp4 family protein( domain architecture ID 10649556)

U4/U6 small nuclear ribonucleoprotein Prp4 family protein may play a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as a component of the precatalytic spliceosome

CATH:  2.130.10.10
Gene Ontology:  GO:0008380|GO:0005681|GO:0005515
PubMed:  30069656|29026209|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-535 2.14e-82

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 262.92  E-value: 2.14e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQvTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWK-TDGTL 331
Cdd:COG2319 118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlATGKL 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 332 LQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLR 411
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVN 491
Cdd:COG2319 277 TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVR 355

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 15227373 492 IWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
121-166 1.83e-14

Splicing Factor Motif, present in Prp18 and Pr04;


:

Pssm-ID: 128776  Cd Length: 44  Bit Score: 67.38  E-value: 1.83e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 15227373    121 TNDKAVRDRLRRLGEPITLFGEQEMERRARLTQLLTRYDingQLDK 166
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD---ELDK 43
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-535 2.14e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 262.92  E-value: 2.14e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQvTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWK-TDGTL 331
Cdd:COG2319 118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlATGKL 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 332 LQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLR 411
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVN 491
Cdd:COG2319 277 TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVR 355

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 15227373 492 IWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 257-535 6.92e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.56  E-value: 6.92e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 257 PLTGCSFSRDGKILATCSLSGVTKLWEMpQVTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKT-DGTLLQTF 335
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLeTGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 336 EGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLRTGRS 415
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 416 ILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVNIWSG 495
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDL 248

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 15227373 496 RDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:cd00200 249 RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
121-166 1.83e-14

Splicing Factor Motif, present in Prp18 and Pr04;


Pssm-ID: 128776  Cd Length: 44  Bit Score: 67.38  E-value: 1.83e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 15227373    121 TNDKAVRDRLRRLGEPITLFGEQEMERRARLTQLLTRYDingQLDK 166
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD---ELDK 43
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 397-538 1.77e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.95  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  397 ASCGLDSLARVWDLRTGRSILVFQGHIKPVFSVNF-SPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANlVSQVKYEP 475
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPS 627

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227373  476 QEGYFLATASYDMKVNIWSGRDFSL-VKSLAGHeSKVASLDITADSSCIATVSHDRTIKLWTSS 538
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGH-SKTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 412-451 1.97e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 1.97e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15227373    412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWD 451
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PRP4 pfam08799
pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. ...
 126-154 2.16e-10

pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.


Pssm-ID: 462606 [Multi-domain]  Cd Length: 29  Bit Score: 55.38  E-value: 2.16e-10
                          10        20
                  ....*....|....*....|....*....
gi 15227373   126 VRDRLRRLGEPITLFGEQEMERRARLTQL 154
Cdd:pfam08799   1 VRRKLRELGEPITLFGETHADRRERLRKL 29
WD40 pfam00400
WD domain, G-beta repeat;
413-451 5.34e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 5.34e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15227373   413 GRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWD 451
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-535 2.14e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 262.92  E-value: 2.14e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQvTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWK-TDGTL 331
Cdd:COG2319 118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlATGKL 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 332 LQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLR 411
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVN 491
Cdd:COG2319 277 TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVR 355

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 15227373 492 IWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 257-535 6.92e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.56  E-value: 6.92e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 257 PLTGCSFSRDGKILATCSLSGVTKLWEMpQVTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKT-DGTLLQTF 335
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLeTGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 336 EGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLRTGRS 415
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 416 ILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVNIWSG 495
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDL 248

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 15227373 496 RDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:cd00200 249 RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
253-535 5.98e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.98  E-value: 5.98e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQvTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKT-DGTL 331
Cdd:COG2319  76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKL 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 332 LQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLR 411
Cdd:COG2319 155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPqEGYFLATASYDMKVN 491
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVR 313

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 15227373 492 IWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
253-494 1.34e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.32  E-value: 1.34e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQvTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTD-GTL 331
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKL 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 332 LQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLR 411
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPqEGYFLATASYDMKVN 491
Cdd:COG2319 319 TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVR 397


                ...
gi 15227373 492 IWS 494
Cdd:COG2319 398 LWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 257-494 5.27e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 200.25  E-value: 5.27e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 257 PLTGCSFSRDGKILATCSLSGVTKLWEMPQvTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTD-GTLLQTF 335
Cdd:cd00200  53 PVRDVAASADGTYLASGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTL 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 336 EGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLRTGRS 415
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227373 416 ILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPqEGYFLATASYDMKVNIWS 494
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 331-535 1.17e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 196.79  E-value: 1.17e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 331 LLQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDL 410
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 411 RTGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKV 490
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTI 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 15227373 491 NIWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
262-535 1.61e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 200.14  E-value: 1.61e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 262 SFSRDGKILATCSLSGVTKLWEmPQVTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKT-DGTLLQTFEGHLD 340
Cdd:COG2319   1 ALSADGAALAAASADLALALLA-AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAaAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 341 RLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLRTGRSILVFQ 420
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 421 GHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVNIWSGRDFSL 500
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKL 238

                       250       260       270
                ....*....|....*....|....*....|....*
gi 15227373 501 VKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
253-453 1.98e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 1.98e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQvTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTD-GTL 331
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGEL 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 332 LQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLR 411
Cdd:COG2319 281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 15227373 412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLR 453
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-451 2.65e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.22  E-value: 2.65e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWEMPQVTNtIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTD-GTL 331
Cdd:cd00200  91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRtGKC 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 332 LQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLR 411
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 15227373 412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWD 451
Cdd:cd00200 250 TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
253-412 1.53e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 1.53e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWEmPQVTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTD-GTL 331
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKL 322

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 332 LQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWDINTGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWDLR 411
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402


                .
gi 15227373 412 T 412
Cdd:COG2319 403 T 403
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
121-166 1.83e-14

Splicing Factor Motif, present in Prp18 and Pr04;


Pssm-ID: 128776  Cd Length: 44  Bit Score: 67.38  E-value: 1.83e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 15227373    121 TNDKAVRDRLRRLGEPITLFGEQEMERRARLTQLLTRYDingQLDK 166
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD---ELDK 43
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 415-540 1.14e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 1.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 415 SILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRmrkslyiipahanlvsqvkyepqegyflatasydmkvniws 494
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE----------------------------------------- 39

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15227373 495 grDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLWTSSGN 540
Cdd:cd00200  40 --TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 397-538 1.77e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.95  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  397 ASCGLDSLARVWDLRTGRSILVFQGHIKPVFSVNF-SPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANlVSQVKYEP 475
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPS 627

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227373  476 QEGYFLATASYDMKVNIWSGRDFSL-VKSLAGHeSKVASLDITADSSCIATVSHDRTIKLWTSS 538
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGH-SKTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 412-451 1.97e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 1.97e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15227373    412 TGRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWD 451
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PRP4 pfam08799
pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. ...
 126-154 2.16e-10

pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.


Pssm-ID: 462606 [Multi-domain]  Cd Length: 29  Bit Score: 55.38  E-value: 2.16e-10
                          10        20
                  ....*....|....*....|....*....
gi 15227373   126 VRDRLRRLGEPITLFGEQEMERRARLTQL 154
Cdd:pfam08799   1 VRRKLRELGEPITLFGETHADRRERLRKL 29
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 249-326 3.60e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 3.60e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15227373 249 CSNFGDDRPLTGCSFSRDGKILATCSLSGVTKLWEMpQVTNTIAVLKDHKERATDVVFSPVDDCLATASADRTAKLWK 326
Cdd:cd00200 213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
413-451 5.34e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 5.34e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15227373   413 GRSILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWD 451
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 328-367 4.53e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15227373    328 DGTLLQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWD 367
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
329-367 1.20e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.20e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15227373   329 GTLLQTFEGHLDRLARVAFHPSGKYLGTTSYDKTWRLWD 367
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 416-553 1.58e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.13  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  416 ILVFQGHIKPVFSVNFSPNGYH-LASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVNIWS 494
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKKLNIID 196

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  495 GRDFSLVKSLAGHES---------KVASLDITADSSciatVSHDRTIKLWtssgnDDEDEEK--ETMDID 553
Cdd:PTZ00421 197 PRDGTIVSSVEAHASaksqrclwaKRKDLIITLGCS----KSQQRQIMLW-----DTRKMASpySTVDLD 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 497-535 1.41e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 15227373    497 DFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 416-493 1.82e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.72  E-value: 1.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  416 ILVFQGHIKPVFSVNFSPNGYH-LASGGEDNQCRIWDLR--------MRKSLYIIPAHANLVSQVKYEPQEGYFLATASY 486
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCFSEiLASGSEDLTIRVWEIPhndesvkeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGF 146


                 ....*..
gi 15227373  487 DMKVNIW 493
Cdd:PTZ00420 147 DSFVNIW 153
PTZ00421 PTZ00421
coronin; Provisional
 345-470 2.19e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  345 VAFHP-SGKYLGTTSYDKTWRLWDI-------NTGAELLLQEGHSRSVYGIAFQQDGA-LAASCGLDSLARVWDLRTGRS 415
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKA 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15227373  416 ILVFQGHIKPVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQ 470
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQ 215
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 262-493 3.86e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 3.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  262 SFSRDGKILATCSLSGVTKLWEMPQVTNT-------IAVLKDHKERATDVVFSPVDDCLATASADRTAKLWKTDGTLLQT 334
Cdd:PLN00181 490 GFDRDGEFFATAGVNKKIKIFECESIIKDgrdihypVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVT 569

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  335 -FEGHLDRLARVAFHPSG-KYLGTTSYDKTWRLWDINTGAELLLQEGHSrSVYGIAFQQDGALAASCG-LDSLARVWDLR 411
Cdd:PLN00181 570 eMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICCVQFPSESGRSLAFGsADHKVYYYDLR 648

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  412 TGR-SILVFQGHIKPVFSVNFSpNGYHLASGGEDNQCRIWDLRMRKS------LYIIPAHANLVSQVKYEPQEGYfLATA 484
Cdd:PLN00181 649 NPKlPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGY-IATG 726


                 ....*....
gi 15227373  485 SYDMKVNIW 493
Cdd:PLN00181 727 SETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
498-535 5.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 15227373   498 FSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 291-326 6.53e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.53e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15227373    291 IAVLKDHKERATDVVFSPVDDCLATASADRTAKLWK 326
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
378-409 1.75e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.75e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15227373   378 EGHSRSVYGIAFQQDGALAASCGLDSLARVWD 409
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 370-409 7.47e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 7.47e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15227373    370 TGAELLLQEGHSRSVYGIAFQQDGALAASCGLDSLARVWD 409
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
291-325 8.03e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 8.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15227373   291 IAVLKDHKERATDVVFSPVDDCLATASADRTAKLW 325
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 500-543 2.31e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.31e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15227373 500 LVKSLAGHESKVASLDITADSSCIATVSHDRTIKLWTSSGNDDE 543
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL 44
WD40 COG2319
WD40 repeat [General function prediction only];
431-540 7.33e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 7.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373 431 FSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVNIWSGRDFSLVKSLAGHESK 510
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPD-GARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110
                ....*....|....*....|....*....|
gi 15227373 511 VASLDITADSSCIATVSHDRTIKLWTSSGN 540
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATG 110
WD40_like pfam17005
WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat ...
 425-540 1.10e-03

WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat family. Members are largely from microsporidia and related species.


Pssm-ID: 407205 [Multi-domain]  Cd Length: 301  Bit Score: 41.19  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373   425 PVFSVNFSPNGYHLASGGEDNQCRIWDLRMRKSLYIIPAHANLVSQVKYEPQEGYFLATAsydmkvniwsgrDFSLVKSL 504
Cdd:pfam17005   2 EIYSIDISKKGSYILYGGKDDTCTVYDFENLDLVSIVEGFSDSVIFCKFLDDDLILVVTL------------DGTIMESL 69

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15227373   505 AGHESKVASLDITADSSCIATVshDRTIKLWTSSGN 540
Cdd:pfam17005  70 LKNDQEIENTKINEDISTVKVT--DDKLLIGTNTGS 103
PTZ00421 PTZ00421
coronin; Provisional
 266-367 2.08e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.65  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  266 DGKILATCSLSGVTKLWEMPQ------VTNTIAVLKDHKERATDVVFSP-VDDCLATASADRTAKLWKTD-GTLLQTFEG 337
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEegltqnISDPIVHLQGHTKKVGIVSFHPsAMNVLASAGADMVVNVWDVErGKAVEVIKC 166

                         90       100       110
                 ....*....|....*....|....*....|
gi 15227373  338 HLDRLARVAFHPSGKYLGTTSYDKTWRLWD 367
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
PTZ00421 PTZ00421
coronin; Provisional
 421-534 4.19e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227373  421 GHIKPVFSVNFSP-NGYHLASGGEDNQCRIWDL-------RMRKSLYIIPAHANLVSQVKYEPQEGYFLATASYDMKVNI 492
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 15227373  493 WSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKL 534
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-283 4.99e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.99e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 15227373    253 GDDRPLTGCSFSRDGKILATCSLSGVTKLWE 283
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 475-535 5.43e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 5.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227373   475 PQEGYFLATASYDMKVNIWSGRDFSLVKSLAGHESKVASLDITADSSCIATVSHDRTIKLW 535
Cdd:pfam20426  91 PSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 455-494 5.85e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.85e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15227373    455 RKSLYIIPAHANLVSQVKYEPQeGYFLATASYDMKVNIWS 494
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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