O-fucosyltransferase family protein may be involved in glycan metabolism by O-fucosylation of protein substrates; similar to O-fucosyltransferases which are involved in glycan metabolism
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
180-502
1.18e-133
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
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Pssm-ID: 211385 Cd Length: 290 Bit Score: 391.16 E-value: 1.18e-133
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
180-502
1.18e-133
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
Pssm-ID: 211385 Cd Length: 290 Bit Score: 391.16 E-value: 1.18e-133
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
180-497
1.20e-70
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.
Pssm-ID: 463023 [Multi-domain] Cd Length: 247 Bit Score: 227.18 E-value: 1.20e-70
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
180-502
1.18e-133
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
Pssm-ID: 211385 Cd Length: 290 Bit Score: 391.16 E-value: 1.18e-133
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
180-497
1.20e-70
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.
Pssm-ID: 463023 [Multi-domain] Cd Length: 247 Bit Score: 227.18 E-value: 1.20e-70
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ...
314-499
6.93e-10
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.
Pssm-ID: 211383 Cd Length: 206 Bit Score: 58.97 E-value: 6.93e-10
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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