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Conserved domains on  [gi|15232200|ref|NP_186830|]
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EEIG1/EHBP1 protein amino-terminal domain protein [Arabidopsis thaliana]

Protein Classification

N-terminal C2 domain-containing protein( domain architecture ID 6127)

N-terminal C2 (NT-C2) domain-containing protein may be involved in the linking of actin/microfilament-binding adaptors to the membrane and may act as a link that tethers endosomal vesicles to the cytoskeleton in course of their intracellular trafficking

PubMed:  20713135

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NT-C2 super family cl11025
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 14-160 9.21e-08

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


The actual alignment was detected with superfamily member pfam10358:

Pssm-ID: 463058  Cd Length: 143  Bit Score: 51.94  E-value: 9.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232200    14 SVQVDYLIHIHDIKPWPPSQSlrslrSVVIQWENGDR--NSGTTSVVapslgsVIGEGKIEFNESFKLPLTLLKDvsarg 91
Cdd:pfam10358   4 KPKFQFVLTIHELQNLPLVGG-----ELFVKWRRGDKkgSSGTTEKA------LVNNGRAIFNEEFSIPVTLFLD----- 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232200    92 KGGDVFFKNVLELNLYEPRREKTHQLLATATIDLAVY-GVVKESFSLTAQMNSKRSyrnaTQPVLYLTIQ 160
Cdd:pfam10358  68 KKGGKYEEKLLEFSVYKVTKKGKKKVLGKASIDLAEYaNLKKKPTTVRFLLKKSSK----KNATLSLSIQ 133
 
Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 14-160 9.21e-08

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


Pssm-ID: 463058  Cd Length: 143  Bit Score: 51.94  E-value: 9.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232200    14 SVQVDYLIHIHDIKPWPPSQSlrslrSVVIQWENGDR--NSGTTSVVapslgsVIGEGKIEFNESFKLPLTLLKDvsarg 91
Cdd:pfam10358   4 KPKFQFVLTIHELQNLPLVGG-----ELFVKWRRGDKkgSSGTTEKA------LVNNGRAIFNEEFSIPVTLFLD----- 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232200    92 KGGDVFFKNVLELNLYEPRREKTHQLLATATIDLAVY-GVVKESFSLTAQMNSKRSyrnaTQPVLYLTIQ 160
Cdd:pfam10358  68 KKGGKYEEKLLEFSVYKVTKKGKKKVLGKASIDLAEYaNLKKKPTTVRFLLKKSSK----KNATLSLSIQ 133
 
Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 14-160 9.21e-08

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


Pssm-ID: 463058  Cd Length: 143  Bit Score: 51.94  E-value: 9.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232200    14 SVQVDYLIHIHDIKPWPPSQSlrslrSVVIQWENGDR--NSGTTSVVapslgsVIGEGKIEFNESFKLPLTLLKDvsarg 91
Cdd:pfam10358   4 KPKFQFVLTIHELQNLPLVGG-----ELFVKWRRGDKkgSSGTTEKA------LVNNGRAIFNEEFSIPVTLFLD----- 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232200    92 KGGDVFFKNVLELNLYEPRREKTHQLLATATIDLAVY-GVVKESFSLTAQMNSKRSyrnaTQPVLYLTIQ 160
Cdd:pfam10358  68 KKGGKYEEKLLEFSVYKVTKKGKKKVLGKASIDLAEYaNLKKKPTTVRFLLKKSSK----KNATLSLSIQ 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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