|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
375-776 |
4.68e-85 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 276.26 E-value: 4.68e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreeelqghSKSSPGCPRV 454
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRL--------DPSRPRAPQA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISKsGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:COG0513 75 LILAPTRELALQVAEELRKLAK-YLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 535 VDILFgDDEFEAALQNLINSSPVTAQYLFVTATLPLEIyNKLVEVF-PDCEVVMGPRVHRVSNALEEFLVDCSGDDnaek 613
Cdd:COG0513 154 ADRML-DMGFIEDIERILKLLPKERQTLLFSATMPPEI-RKLAKRYlKNPVRIEVAPENATAETIEQRYYLVDKRD---- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 614 tpetafqnKKTALLQIMEENPVSKTIIFCNKIETCRKVENIFKRvdrkeRQLHVLPFHAALSQESRLTNMQEFTSSQPEe 693
Cdd:COG0513 228 --------KLELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQK-----RGISAAALHGDLSQGQRERALDAFRNGKIR- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 694 nslFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARgKGKAFIFVVGKQVGLARRIIERNEKGHPVHDV 773
Cdd:COG0513 294 ---VLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGA-EGTAISLVTPDERRLLRAIEKLIGQKIEEEEL 369
|
...
gi 15231353 774 PNA 776
Cdd:COG0513 370 PGF 372
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
385-574 |
1.18e-62 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 208.45 E-value: 1.18e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEElqghsKSSPGCPRVIVLVPTAELA 464
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEP-----KKKGRGPQALVLAPTRELA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 465 SQVLANCRSISKsGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEF 544
Cdd:cd00268 76 MQIAEVARKLGK-GTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRML-DMGF 153
|
170 180 190
....*....|....*....|....*....|
gi 15231353 545 EAALQNLINSSPVTAQYLFVTATLPLEIYN 574
Cdd:cd00268 154 EEDVEKILSALPKDRQTLLFSATLPEEVKE 183
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
374-762 |
2.96e-40 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 153.94 E-value: 2.96e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 374 KTFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQrlreeELQGHSKSSPGCPR 453
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQ-----HLLDFPRRKSGPPR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 454 VIVLVPTAELASQVLANCRSISKsGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILD 533
Cdd:PRK11192 76 ILILTPTRELAMQVADQARELAK-HTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 534 EVDILFgDDEFEAALQNLINSSPVTAQYLFVTATLPleiyNKLVEVFpdcevvmgprVHRVSNALEEFLVDCS------- 606
Cdd:PRK11192 155 EADRML-DMGFAQDIETIAAETRWRKQTLLFSATLE----GDAVQDF----------AERLLNDPVEVEAEPSrrerkki 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 607 ------GDDNaektpetafqNKKTALL-QIMEENPVSKTIIFCNKIETCRKVENIFkrvdrKERQLHVLPFHAALSQESR 679
Cdd:PRK11192 220 hqwyyrADDL----------EHKTALLcHLLKQPEVTRSIVFVRTRERVHELAGWL-----RKAGINCCYLEGEMVQAKR 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 680 LTNMQEFTSSqpEENslFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARgKGKAFIFV-------VGK 752
Cdd:PRK11192 285 NEAIKRLTDG--RVN--VLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGR-KGTAISLVeahdhllLGK 359
|
410
....*....|....*
gi 15231353 753 -----QVGLARRIIE 762
Cdd:PRK11192 360 ieryiEEPLKARVID 374
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
598-749 |
2.24e-37 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 136.10 E-value: 2.24e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 598 LEEFLVDCSGDDNaektpetafqnKKTALLQIMEENPVSKTIIFCNKIETCRKVENIFKrvdrkERQLHVLPFHAALSQE 677
Cdd:cd18787 1 IKQLYVVVEEEEK-----------KLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLE-----ELGIKVAALHGDLSQE 64
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15231353 678 SRLTNMQEFTSSQpeenSLFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARgKGKAFIFV 749
Cdd:cd18787 65 ERERALKKFRSGK----VRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGR-KGTAITFV 131
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
375-761 |
5.20e-37 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 146.46 E-value: 5.20e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQghsksSPG-CPR 453
Cdd:PTZ00110 131 SFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLL-----RYGdGPI 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 454 VIVLVPTAELASQVLANCRSISKSGvPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILD 533
Cdd:PTZ00110 206 VLVLAPTRELAEQIREQCNKFGASS-KIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLD 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 534 EVDILFgDDEFEAALQNLINSSPVTAQYLFVTATLPLEIyNKLVEVFPDCEVV---MGP----RVHRVSNalEEFLVdcs 606
Cdd:PTZ00110 285 EADRML-DMGFEPQIRKIVSQIRPDRQTLMWSATWPKEV-QSLARDLCKEEPVhvnVGSldltACHNIKQ--EVFVV--- 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 607 gdDNAEKTpetafQNKKTALLQIMEENPvsKTIIFCnkiETCRKVENIFK--RVDrkerQLHVLPFHAALSQESRLTNMQ 684
Cdd:PTZ00110 358 --EEHEKR-----GKLKMLLQRIMRDGD--KILIFV---ETKKGADFLTKelRLD----GWPALCIHGDKKQEERTWVLN 421
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15231353 685 EFTSSQpeenSLFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARgARGKGKAFIFVVGKQVGLARRII 761
Cdd:PTZ00110 422 EFKTGK----SPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGR-AGAKGASYTFLTPDKYRLARDLV 493
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
375-760 |
3.10e-36 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 141.50 E-value: 3.10e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreeelqghSKSSPGCpRV 454
Cdd:PTZ00424 29 SFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLI--------DYDLNAC-QA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISKSgVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:PTZ00424 100 LILAPTRELAQQIQKVVLALGDY-LKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 535 VDILFGDDeFEAALQNLINSSPVTAQYLFVTATLPLEIYNKLVEVFPDCEVVMGPRVHRVSNALEEFLVDCSGDDnaekt 614
Cdd:PTZ00424 179 ADEMLSRG-FKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEE----- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 615 petafqNKKTALLQIMEENPVSKTIIFCNkieTCRKVENIFKRVdrKERQLHVLPFHAALSQESRLTNMQEFTSSqpeeN 694
Cdd:PTZ00424 253 ------WKFDTLCDLYETLTITQAIIYCN---TRRKVDYLTKKM--HERDFTVSCMHGDMDQKDRDLIMREFRSG----S 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231353 695 SLFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARgKGKAFIFVVGKQVGLARRI 760
Cdd:PTZ00424 318 TRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGR-KGVAINFVTPDDIEQLKEI 382
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
388-594 |
3.43e-36 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 136.34 E-value: 3.43e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 388 ALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQR-LREEELQGHSKSSpgcPRVIVLVPTAELASQ 466
Cdd:cd17948 4 ILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRlLRYKLLAEGPFNA---PRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 467 VLANCRSISKsGVPFRSMVVTGGfRQRTQLENLEQG-VDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEFE 545
Cdd:cd17948 81 IGSVAQSLTE-GLGLKVKVITGG-RTKRQIRNPHFEeVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLL-DDSFN 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15231353 546 AALQNLINSSPVT-------------AQYLFVTATLPL---EIYNKLVEVfPDCEVVMGPRVHRV 594
Cdd:cd17948 158 EKLSHFLRRFPLAsrrsentdgldpgTQLVLVSATMPSgvgEVLSKVIDV-DSIETVTSDKLHRL 221
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
372-741 |
6.25e-36 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 140.88 E-value: 6.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 372 SRKTFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEelQGHSKSSPGC 451
Cdd:PRK04837 6 TEQKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSH--PAPEDRKVNQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 452 PRVIVLVPTAELASQVLANCRSISKSgVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAI 531
Cdd:PRK04837 84 PRALIMAPTRELAVQIHADAEPLAQA-TGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 532 LDEVDILFgDDEFEAALQNLINSSPVTAQYL--FVTATLPLEIYNKLVEVFPDCE-VVMGPRV---HRVSnalEEfLVDC 605
Cdd:PRK04837 163 LDEADRMF-DLGFIKDIRWLFRRMPPANQRLnmLFSATLSYRVRELAFEHMNNPEyVEVEPEQktgHRIK---EE-LFYP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 606 SGDDnaektpetafqnkKTALLQ-IMEENPVSKTIIFCNKIETCrkvENIFKRVDRKERQLHVLPfhAALSQESRLTNMQ 684
Cdd:PRK04837 238 SNEE-------------KMRLLQtLIEEEWPDRAIIFANTKHRC---EEIWGHLAADGHRVGLLT--GDVAQKKRLRILE 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15231353 685 EFTSSQPEenslFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTAR-GARG 741
Cdd:PRK04837 300 EFTRGDLD----ILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRaGASG 353
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
400-574 |
1.24e-35 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 132.37 E-value: 1.24e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 400 IQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEElqghsksspGCPRVIVLVPTAELASQVLANCRSISKsGV 479
Cdd:pfam00270 3 IQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLD---------NGPQALVLAPTRELAEQIYEELKKLGK-GL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 480 PFRSMVVTGGFRQRTQLENLeQGVDVLIATPGRFTYLMNEGILgLSNLRCAILDEVDiLFGDDEFEAALQNLINSSPVTA 559
Cdd:pfam00270 73 GLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERKL-LKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKR 149
|
170
....*....|....*
gi 15231353 560 QYLFVTATLPLEIYN 574
Cdd:pfam00270 150 QILLLSATLPRNLED 164
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
376-746 |
3.86e-34 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 136.97 E-value: 3.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 376 FAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQghSKSSPGCPRVI 455
Cdd:PRK01297 89 FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPP--KERYMGEPRAL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 456 VLVPTAELASQVLANCRSISK-SGVPFRSMVvtGGFRQRTQLENLE-QGVDVLIATPGRFTYLMNEGILGLSNLRCAILD 533
Cdd:PRK01297 167 IIAPTRELVVQIAKDAAALTKyTGLNVMTFV--GGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEVMVLD 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 534 EVDILFgDDEFEAALQNLINSSPVTA--QYLFVTATLPLEIYNKLVEVFPDCEVVMGPRVHRVSNALEEFLVDCSGDDna 611
Cdd:PRK01297 245 EADRML-DMGFIPQVRQIIRQTPRKEerQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSD-- 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 612 ektpetafqnKKTALLQIMEENPVSKTIIFCNKIETCRKVENIFKRVDRKERQLHvlpfhAALSQESRLTNMQEFTssqp 691
Cdd:PRK01297 322 ----------KYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLS-----GDVPQHKRIKTLEGFR---- 382
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15231353 692 EENSLFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTAR-GARGKGKAF 746
Cdd:PRK01297 383 EGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRaGASGVSISF 438
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
376-574 |
3.93e-34 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 129.34 E-value: 3.93e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 376 FAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQghsksspgcPRVI 455
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDV---------IQAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 456 VLVPTAELASQVLANCRSISKsGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEV 535
Cdd:cd17940 72 ILVPTRELALQTSQVCKELGK-HMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEA 150
|
170 180 190
....*....|....*....|....*....|....*....
gi 15231353 536 DILFgDDEFEAALQNLINSSPVTAQYLFVTATLPLEIYN 574
Cdd:cd17940 151 DKLL-SQDFQPIIEKILNFLPKERQILLFSATFPLTVKN 188
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
375-763 |
4.48e-34 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 136.48 E-value: 4.48e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQGHSKSSpgcPRV 454
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRP---VRA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISKSgVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:PRK10590 79 LILTPTRELAAQIGENVRDYSKY-LNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 535 VDILFgDDEFEAALQNLINSSPVTAQYLFVTATLPLEI---YNKLVEVFPDCEVVmgpRVHRVSNALEEF--LVDcsgdd 609
Cdd:PRK10590 158 ADRML-DMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIkalAEKLLHNPLEIEVA---RRNTASEQVTQHvhFVD----- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 610 naektpetafQNKKTALL-QIMEENPVSKTIIFC-NKIETCRKVENIFKrvdrkeRQLHVLPFHAALSQESRLTNMQEFT 687
Cdd:PRK10590 229 ----------KKRKRELLsQMIGKGNWQQVLVFTrTKHGANHLAEQLNK------DGIRSAAIHGNKSQGARTRALADFK 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231353 688 SSQPEenslFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARgKGKAFIFVVGKQVGLARRiIER 763
Cdd:PRK10590 293 SGDIR----VLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAA-TGEALSLVCVDEHKLLRD-IEK 362
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
375-746 |
4.42e-33 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 135.08 E-value: 4.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEElqGHSKSSPGCPRV 454
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRP--ALADRKPEDPRA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQvlancrsISKSGVPF------RSMVVTGGFRQRTQLENLEQGVDVLIATPGRFT-YLMNEGILGLSNL 527
Cdd:PRK04537 88 LILAPTRELAIQ-------IHKDAVKFgadlglRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIdYVKQHKVVSLHAC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 528 RCAILDEVDILFgDDEFEAALQNLINSSP--VTAQYLFVTATLP-------LEIYNKLVEVFPDCEVVMGPRV-HRVSNA 597
Cdd:PRK04537 161 EICVLDEADRMF-DLGFIKDIRFLLRRMPerGTRQTLLFSATLShrvlelaYEHMNEPEKLVVETETITAARVrQRIYFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 598 LEEflvdcsgddnaektpetafqNKKTALLQIMEENPVSKTIIFCNkieTCRKVENIFKRVDRKERQLHVLPfhAALSQE 677
Cdd:PRK04537 240 ADE--------------------EKQTLLLGLLSRSEGARTMVFVN---TKAFVERVARTLERHGYRVGVLS--GDVPQK 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 678 SRLTNMQEFTSSQPEenslFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTAR-GARGKGKAF 746
Cdd:PRK04537 295 KRESLLNRFQKGQLE----ILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARlGEEGDAISF 360
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
376-568 |
9.68e-33 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 125.41 E-value: 9.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 376 FAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEelqghskssPGCPRVI 455
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSED---------PYGIFAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 456 VLVPTAELASQVLANCRSISKSgVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRF-TYLMN--EGILGLSNLRCAIL 532
Cdd:cd17955 72 VLTPTRELAYQIAEQFRALGAP-LGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLaDHLRSsdDTTKVLSRVKFLVL 150
|
170 180 190
....*....|....*....|....*....|....*.
gi 15231353 533 DEVDILFGDDeFEAALQNLINSSPVTAQYLFVTATL 568
Cdd:cd17955 151 DEADRLLTGS-FEDDLATILSALPPKRQTLLFSATL 185
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
389-590 |
9.70e-33 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 125.68 E-value: 9.70e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 389 LKEQNFDRPAHIQAMAFSPVIDG-KSCIIADQSGSGKTLAYLVPVIQRLREEelqghsksspGCPRVIVLVPTAELASQV 467
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRG----------KGGRVLVLVPTRELAEQW 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 468 LANCRSISKSgVPFRSMVVTGGFRQRTQLENLEQGV-DVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEFEA 546
Cdd:smart00487 71 AEELKKLGPS-LGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLL-DGGFGD 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15231353 547 ALQNLINSSPVTAQYLFVTATLPLEIYNKLVEVFPDCEVVMGPR 590
Cdd:smart00487 149 QLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGF 192
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
375-572 |
1.77e-32 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 126.62 E-value: 1.77e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQGHSKSSPGCPRV 454
Cdd:cd18052 44 TFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSEVQEPQA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISKsGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:cd18052 124 LIVAPTRELANQIFLEARKFSY-GTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYLILDE 202
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15231353 535 VDILFgDDEFEAALQNLINSSPVTA----QYLFVTATLPLEI 572
Cdd:cd18052 203 ADRML-DMGFGPEIRKLVSEPGMPSkedrQTLMFSATFPEEI 243
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
375-749 |
2.71e-32 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 132.22 E-value: 2.71e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQGHSKSSPgcPRV 454
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGHPSEQRN--PLA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISKsGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:PLN00206 200 MVLTPTRELCVQVEDQAKVLGK-GLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDE 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 535 VDILFGDDEFEAALQnlINSSPVTAQYLFVTATLPleiynklvevfpdcevvmgPRVHRVSNAL-EEFLVDCSGDDNAek 613
Cdd:PLN00206 279 VDCMLERGFRDQVMQ--IFQALSQPQVLLFSATVS-------------------PEVEKFASSLaKDIILISIGNPNR-- 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 614 tPETAFQ---------NKKTALLQIMEEN-----PVsktIIFCNKietcRKVENIFKRVDRKERQLHVLPFHAALSQESR 679
Cdd:PLN00206 336 -PNKAVKqlaiwvetkQKKQKLFDILKSKqhfkpPA---VVFVSS----RLGADLLANAITVVTGLKALSIHGEKSMKER 407
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15231353 680 LTNMQEF-TSSQPeenslFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARgKGKAFIFV 749
Cdd:PLN00206 408 REVMKSFlVGEVP-----VIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGE-KGTAIVFV 472
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
385-572 |
6.56e-32 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 122.75 E-value: 6.56e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreeelqGHSKSSPGCPRVIVLVPTAELA 464
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERL------LYRPKKKAATRVLVLVPTRELA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 465 SQVLANCRSISK-SGVpfRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFT-YLMNEGILGLSNLRCAILDEVDILFgDD 542
Cdd:cd17947 75 MQCFSVLQQLAQfTDI--TFALAVGGLSLKAQEAALRARPDIVIATPGRLIdHLRNSPSFDLDSIEILVLDEADRML-EE 151
|
170 180 190
....*....|....*....|....*....|
gi 15231353 543 EFEAALQNLINSSPVTAQYLFVTATLPLEI 572
Cdd:cd17947 152 GFADELKEILRLCPRTRQTMLFSATMTDEV 181
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
416-593 |
9.63e-32 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 124.41 E-value: 9.63e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 416 IADQSGSGKTLAYLVPVIQRLREEELQ--------GHSKSSPGCPRVIVLVPTAELASQVLANCRSISKSgVPFRSMVVT 487
Cdd:cd17965 66 LAAETGSGKTLAYLAPLLDYLKRQEQEpfeeaeeeYESAKDTGRPRSVILVPTHELVEQVYSVLKKLSHT-VKLGIKTFS 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 488 GGFRQRTQ--LENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEFEAALQNLINSSPVTAQYLFVT 565
Cdd:cd17965 145 SGFGPSYQrlQLAFKGRIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLF-DRSFLQDTTSIIKRAPKLKHLILCS 223
|
170 180
....*....|....*....|....*...
gi 15231353 566 ATLPLEIYNKLVEVFPDCEVVMGPRVHR 593
Cdd:cd17965 224 ATIPKEFDKTLRKLFPDVVRIATPRLHA 251
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
375-572 |
1.34e-31 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 122.98 E-value: 1.34e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAfSPVIDGKSCIIA-DQSGSGKTLAYLVPVIQR-LREEELQGHSKSSPGCP 452
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYA-IPIILAGRDLMAcAQTGSGKTAAFLLPIISKlLEDGPPSVGRGRRKAYP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 453 RVIVLVPTAELASQVLANCRSISK-SGVpfRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAI 531
Cdd:cd17967 80 SALILAPTRELAIQIYEEARKFSYrSGV--RSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLV 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 15231353 532 LDEVD-ILfgDDEFEAALQNLINSSPVTA----QYLFVTATLPLEI 572
Cdd:cd17967 158 LDEADrML--DMGFEPQIRKIVEHPDMPPkgerQTLMFSATFPREI 201
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
375-776 |
1.53e-31 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 131.12 E-value: 1.53e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLrEEELQGhsksspgcPRV 454
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL-DPELKA--------PQI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISKSGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:PRK11634 78 LVLAPTRELAVQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 535 VDIL----FGDDefeaaLQNLINSSPVTAQYLFVTATLPlEIYNKLVEVFpdcevVMGPRVHRVSNALeeflvdCSGDDN 610
Cdd:PRK11634 158 ADEMlrmgFIED-----VETIMAQIPEGHQTALFSATMP-EAIRRITRRF-----MKEPQEVRIQSSV------TTRPDI 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 611 AEKTPETAFQNKKTALLQIMEENPVSKTIIFCNKIETCRKVENIFKRVDRKErqlhvlpfhAALSQESRLTnMQEFTSSQ 690
Cdd:PRK11634 221 SQSYWTVWGMRKNEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNS---------AALNGDMNQA-LREQTLER 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 691 PEENSL-FLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARGkGKAFIFVVGKQVGLARRiIERNEK-GH 768
Cdd:PRK11634 291 LKDGRLdILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRA-GRALLFVENRERRLLRN-IERTMKlTI 368
|
....*...
gi 15231353 769 PVHDVPNA 776
Cdd:PRK11634 369 PEVELPNA 376
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
375-578 |
2.50e-30 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 118.56 E-value: 2.50e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRlreeeLQGHSKSSpGCpRV 454
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEK-----LKAHSPTV-GA-RA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISKsGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:cd17959 75 LILSPTRELALQTLKVTKELGK-FTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDE 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15231353 535 VDILFGDDeFEAALQNLINSSPVTAQYLFVTATLPleiyNKLVE 578
Cdd:cd17959 154 ADRLFEMG-FAEQLHEILSRLPENRQTLLFSATLP----KLLVE 192
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
385-569 |
2.78e-30 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 118.34 E-value: 2.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreeELQGHSKSSPGCPRVIVLVPTAELA 464
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHL---DLQPIPREQRNGPGVLVLTPTRELA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 465 SQVLANCRSISKSGvpFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEF 544
Cdd:cd17958 78 LQIEAECSKYSYKG--LKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRML-DMGF 154
|
170 180
....*....|....*....|....*
gi 15231353 545 EAALQNLINSSPVTAQYLFVTATLP 569
Cdd:cd17958 155 EPQIRKILLDIRPDRQTIMTSATWP 179
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
385-576 |
1.04e-29 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 117.73 E-value: 1.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSP-VIDGKSCIIADQSGSGKTLAYLVPVIQR-LREEELQGHSKSSPGcPRVIVLVPTAE 462
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILERlLSQKSSNGVGGKQKP-LRALILTPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 463 LASQVLANCRSISKSGvPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNL---RCAILDEVDILF 539
Cdd:cd17946 80 LAVQVKDHLKAIAKYT-NIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLANLkslRFLVLDEADRML 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15231353 540 GD---DEFEAALqNLINSSPVTA----QYLFVTATLPLEIYNKL 576
Cdd:cd17946 159 EKghfAELEKIL-ELLNKDRAGKkrkrQTFVFSATLTLDHQLPL 201
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
386-572 |
3.19e-29 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 115.76 E-value: 3.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 386 MKALKEQNFDRPAHIQAMAFSPVI-DGKSCIIADQSGSGKTLAYLVPVIQRLreeeLQGHSKSSPGCPRVIVLVPTAELA 464
Cdd:cd17964 6 LKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSL----LNTKPAGRRSGVSALIISPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 465 SQVLANCRSISKSGVPFRSMVVTGGFRQRTQLENLE-QGVDVLIATPGRFT-YLMNEGILG-LSNLRCAILDEVDILFgD 541
Cdd:cd17964 82 LQIAAEAKKLLQGLRKLRVQSAVGGTSRRAELNRLRrGRPDILVATPGRLIdHLENPGVAKaFTDLDYLVLDEADRLL-D 160
|
170 180 190
....*....|....*....|....*....|....*
gi 15231353 542 DEFEAALQNLI----NSSPVTAQYLFVTATLPLEI 572
Cdd:cd17964 161 MGFRPDLEQILrhlpEKNADPRQTLLFSATVPDEV 195
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
386-572 |
7.94e-29 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 114.22 E-value: 7.94e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 386 MKALKEQNFDRPAHIQaMAFSPVI-DGKSCIIADQSGSGKTLAYLVPVIQRLREeelqghSKSSPGcPRVIVLVPTAELA 464
Cdd:cd17957 2 LNNLEESGYREPTPIQ-MQAIPILlHGRDLLACAPTGSGKTLAFLIPILQKLGK------PRKKKG-LRALILAPTRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 465 SQVLANCRSISKsGVPFRSMVVTGGFR-QRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDE 543
Cdd:cd17957 74 SQIYRELLKLSK-GTGLRIVLLSKSLEaKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLF-EPG 151
|
170 180 190
....*....|....*....|....*....|.
gi 15231353 544 FEAALQNLIN--SSPVTaQYLFVTATLPLEI 572
Cdd:cd17957 152 FREQTDEILAacTNPNL-QRSLFSATIPSEV 181
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
372-760 |
1.32e-28 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 119.91 E-value: 1.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 372 SRKTFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreeelqghsksSPGC 451
Cdd:PRK11776 2 SMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKL-----------DVKR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 452 PRV--IVLVPTAELASQVLANCRSISksgvpfRSM----VVT--GGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILG 523
Cdd:PRK11776 71 FRVqaLVLCPTRELADQVAKEIRRLA------RFIpnikVLTlcGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLD 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 524 LSNLRCAILDEVD-ILfgDDEFEAALQNLINSSPVTAQYLFVTATLPLEIyNKLVEvfpdcevvmgprvhRVSNALEEFL 602
Cdd:PRK11776 145 LDALNTLVLDEADrML--DMGFQDAIDAIIRQAPARRQTLLFSATYPEGI-AAISQ--------------RFQRDPVEVK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 603 VDCSGDDNA------EKTPetafqNKKTALLQIM--EENPVSkTIIFCNKIETCRKVenifkrVDR-KERQLHVLPFHAA 673
Cdd:PRK11776 208 VESTHDLPAieqrfyEVSP-----DERLPALQRLllHHQPES-CVVFCNTKKECQEV------ADAlNAQGFSALALHGD 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 674 LSQESRLTNMQEF---TSSqpeenslFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARgARGKGKAFIFVV 750
Cdd:PRK11776 276 LEQRDRDQVLVRFanrSCS-------VLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGR-AGSKGLALSLVA 347
|
410
....*....|
gi 15231353 751 GKQVGLARRI 760
Cdd:PRK11776 348 PEEMQRANAI 357
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
386-567 |
2.10e-27 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 110.14 E-value: 2.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 386 MKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLReeELQGHSKSSPGCprvIVLVPTAELAS 465
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLY--KLKFKPRNGTGV---IIISPTRELAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 466 QVLANCRSISKSGVPFRSMVVtGGFRQRTQLENLEQGVDVLIATPGR-FTYLMNEGILGLSNLRCAILDEVD-ILfgDDE 543
Cdd:cd17942 77 QIYGVAKELLKYHSQTFGIVI-GGANRKAEAEKLGKGVNILVATPGRlLDHLQNTKGFLYKNLQCLIIDEADrIL--EIG 153
|
170 180
....*....|....*....|....
gi 15231353 544 FEAALQNLINSSPVTAQYLFVTAT 567
Cdd:cd17942 154 FEEEMRQIIKLLPKRRQTMLFSAT 177
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
374-569 |
3.92e-27 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 110.16 E-value: 3.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 374 KTFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPViqrLREEELQGHSKSSPGcPR 453
Cdd:cd17953 12 QKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPM---FRHIKDQRPVKPGEG-PI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 454 VIVLVPTAELASQVLANCRSISKSgVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYL--MNEG-ILGLSNLRCA 530
Cdd:cd17953 88 GLIMAPTRELALQIYVECKKFSKA-LGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDIltANNGrVTNLRRVTYV 166
|
170 180 190
....*....|....*....|....*....|....*....
gi 15231353 531 ILDEVDILFgDDEFEAALQNLINSSPVTAQYLFVTATLP 569
Cdd:cd17953 167 VLDEADRMF-DMGFEPQIMKIVNNIRPDRQTVLFSATFP 204
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
385-572 |
1.01e-26 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 108.23 E-value: 1.01e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREeelQGHSKSSPGcPRVIVLVPTAELA 464
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINA---QPPLERGDG-PIVLVLAPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 465 SQVLANCRSISKSGvPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEF 544
Cdd:cd17966 77 QQIQQEANKFGGSS-RLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRML-DMGF 154
|
170 180
....*....|....*....|....*...
gi 15231353 545 EAALQNLINSSPVTAQYLFVTATLPLEI 572
Cdd:cd17966 155 EPQIRKIVDQIRPDRQTLMWSATWPKEV 182
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
389-572 |
1.71e-26 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 107.25 E-value: 1.71e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 389 LKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEelqghSKSspgcPRVIVLVPTAELASQVL 468
Cdd:cd17962 5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTE-----HRN----PSALILTPTRELAVQIE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 469 ANCRSISKSGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEFEAAL 548
Cdd:cd17962 76 DQAKELMKGLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTML-KMGFQQQV 154
|
170 180
....*....|....*....|....
gi 15231353 549 QNLINSSPVTAQYLFVTATLPLEI 572
Cdd:cd17962 155 LDILENISHDHQTILVSATIPRGI 178
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
375-572 |
1.78e-25 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 105.89 E-value: 1.78e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFsPVIDGKSCIIA-DQSGSGKTLAYLVPVIQRLREeelQGHSKSSPGC-- 451
Cdd:cd18051 22 TFSDLDLGEIIRNNIELARYTKPTPVQKHAI-PIIKSKRDLMAcAQTGSGKTAAFLLPILSQIYE---QGPGESLPSEsg 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 452 --------PRVIVLVPTAELASQVLANCRSIS-KSGVpfRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGIL 522
Cdd:cd18051 98 yygrrkqyPLALVLAPTRELASQIYDEARKFAyRSRV--RPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKI 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 15231353 523 GLSNLRCAILDEVDILFgDDEFEAALQNLI--NSSPVTA--QYLFVTATLPLEI 572
Cdd:cd18051 176 GLDYCKYLVLDEADRML-DMGFEPQIRRIVeqDTMPPTGerQTLMFSATFPKEI 228
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
376-580 |
1.85e-25 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 105.48 E-value: 1.85e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 376 FAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQGHSKSspgcPRVI 455
Cdd:cd18049 26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDG----PICL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 456 VLVPTAELASQVLANCRSISKSgVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEV 535
Cdd:cd18049 102 VLAPTRELAQQVQQVAAEYGRA-CRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEA 180
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 15231353 536 DILFgDDEFEAALQNLINSSPVTAQYLFVTATLPLEIyNKLVEVF 580
Cdd:cd18049 181 DRML-DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEV-RQLAEDF 223
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
385-569 |
2.46e-25 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 104.59 E-value: 2.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQ-NFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreEELQGHSKSSPGCpRVIVLVPTAEL 463
Cdd:cd17949 1 LVSHLKSKmGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRL--LSLEPRVDRSDGT-LALVLVPTREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 464 ASQVLANCRSISKsgvPFRSMV---VTGGFRQRTQLENLEQGVDVLIATPGRFTY-LMNEGILGLSNLRCAILDEVDIL- 538
Cdd:cd17949 78 ALQIYEVLEKLLK---PFHWIVpgyLIGGEKRKSEKARLRKGVNILIATPGRLLDhLKNTQSFDVSNLRWLVLDEADRLl 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15231353 539 ---FGDD--------EFEAALQNLINSSPVTAQYLFVTATLP 569
Cdd:cd17949 155 dmgFEKDitkilellDDKRSKAGGEKSKPSRRQTVLVSATLT 196
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
400-574 |
3.35e-25 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 103.77 E-value: 3.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 400 IQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLrEEELQGHSKSSPgcPRVIVLVPTAELASQVLANCRSISksgv 479
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKL-QEDQQPRKRGRA--PKVLVLAPTRELANQVTKDFKDIT---- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 480 pfRSMVVT---GGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEFEAALQNLIN--- 553
Cdd:cd17944 89 --RKLSVAcfyGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQML-DMGFAEQVEEILSvsy 165
|
170 180
....*....|....*....|...
gi 15231353 554 --SSPVTAQYLFVTATLPLEIYN 574
Cdd:cd17944 166 kkDSEDNPQTLLFSATCPDWVYN 188
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
375-568 |
8.65e-25 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 102.78 E-value: 8.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 375 TFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREeelqghsksSPGCPRV 454
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLE---------NPQRFFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISkSGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTY-LMNEGILGLSNLRCAILD 533
Cdd:cd17954 72 LVLAPTRELAQQISEQFEALG-SSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDhLENTKGFSLKSLKFLVMD 150
|
170 180 190
....*....|....*....|....*....|....*.
gi 15231353 534 EVDILFgDDEFEAALQNLINSSPVTAQ-YLFvTATL 568
Cdd:cd17954 151 EADRLL-NMDFEPEIDKILKVIPRERTtYLF-SATM 184
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
376-568 |
8.93e-25 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 102.78 E-value: 8.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 376 FAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLReeelqghsksspgcprVI 455
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV----------------AL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 456 VLVPTAELASQVLANCRSISK--SGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILD 533
Cdd:cd17938 65 ILEPSRELAEQTYNCIENFKKylDNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLD 144
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15231353 534 EVDILFGDDEfEAALQNLINSSPVTA------QYLFVTATL 568
Cdd:cd17938 145 EADRLLSQGN-LETINRIYNRIPKITsdgkrlQVIVCSATL 184
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
385-572 |
1.57e-24 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 101.72 E-value: 1.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREE-ELQGHSKsspgcPRVIVLVPTAEL 463
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQrELEKGEG-----PIAVIVAPTREL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 464 ASQVLANCRSISKSgVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDE 543
Cdd:cd17952 76 AQQIYLEAKKFGKA-YNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMF-DMG 153
|
170 180
....*....|....*....|....*....
gi 15231353 544 FEAALQNLINSSPVTAQYLFVTATLPLEI 572
Cdd:cd17952 154 FEYQVRSIVGHVRPDRQTLLFSATFKKKI 182
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
378-572 |
2.37e-24 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 101.25 E-value: 2.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 378 EIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRL--REEELQghsksspgcprVI 455
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIdtTVRETQ-----------AL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 456 VLVPTAELASQVLANCRSI-SKSGVpfRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:cd17939 70 VLAPTRELAQQIQKVVKALgDYMGV--KVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDE 147
|
170 180 190
....*....|....*....|....*....|....*...
gi 15231353 535 VDILFgDDEFEAALQNLINSSPVTAQYLFVTATLPLEI 572
Cdd:cd17939 148 ADEML-SRGFKDQIYDIFQFLPPETQVVLFSATMPHEV 184
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
385-574 |
5.23e-24 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 100.49 E-value: 5.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEElqghsKSSPGC----PRVIVLVPT 460
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQE-----KKLPFIkgegPYGLIVCPS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 461 AELASQ----VLANCRSISKSGVP-FRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEV 535
Cdd:cd17951 76 RELARQthevIEYYCKALQEGGYPqLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEA 155
|
170 180 190
....*....|....*....|....*....|....*....
gi 15231353 536 DILFgDDEFEAALQNLINSSPVTAQYLFVTATLPLEIYN 574
Cdd:cd17951 156 DRMI-DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQN 193
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
387-568 |
5.44e-24 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 100.35 E-value: 5.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 387 KALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELqghSKSSPGCPRVIVLVPTAELASQ 466
Cdd:cd17961 7 KAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKA---ESGEEQGTRALILVPTRELAQQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 467 VLANCRSISKSGVPFRSMVVTGGF----RQRTQLENLEqgvDVLIATPGRFTYLMNEGILGL-SNLRCAILDEVDIL--F 539
Cdd:cd17961 84 VSKVLEQLTAYCRKDVRVVNLSASssdsVQRALLAEKP---DIVVSTPARLLSHLESGSLLLlSTLKYLVIDEADLVlsY 160
|
170 180
....*....|....*....|....*....
gi 15231353 540 GddeFEAALQNLINSSPVTAQYLFVTATL 568
Cdd:cd17961 161 G---YEEDLKSLLSYLPKNYQTFLMSATL 186
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
386-576 |
5.79e-24 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 100.03 E-value: 5.79e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 386 MKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQghsksspgcPRVIVLVPTAELAS 465
Cdd:cd17943 2 LEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRH---------PQVLILAPTREIAV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 466 QVLANCRSISKSGVPFRSMVVTGGfrqRTQLENLEQ--GVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDE 543
Cdd:cd17943 73 QIHDVFKKIGKKLEGLKCEVFIGG---TPVKEDKKKlkGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLM-EGS 148
|
170 180 190
....*....|....*....|....*....|...
gi 15231353 544 FEAALQNLINSSPVTAQYLFVTATLPLEIYNKL 576
Cdd:cd17943 149 FQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLL 181
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
385-580 |
2.59e-23 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 100.47 E-value: 2.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREeelQGHSKSSPGcPRVIVLVPTAELA 464
Cdd:cd18050 73 VMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINH---QPYLERGDG-PICLVLAPTRELA 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 465 SQVLANCRSISKSGvPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDEF 544
Cdd:cd18050 149 QQVQQVADDYGKSS-RLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRML-DMGF 226
|
170 180 190
....*....|....*....|....*....|....*.
gi 15231353 545 EAALQNLINSSPVTAQYLFVTATLPLEIyNKLVEVF 580
Cdd:cd18050 227 EPQIRKIVDQIRPDRQTLMWSATWPKEV-RQLAEDF 261
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
621-737 |
2.99e-23 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 94.97 E-value: 2.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 621 NKKTALLQIMEENPVSKTIIFCNKIETCrKVENIFKRvdrkeRQLHVLPFHAALSQESRLTNMQEFtssqPEENSLFLVC 700
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTL-EAELLLEK-----EGIKVARLHGDLSQEEREEILEDF----RKGKIDVLVA 70
|
90 100 110
....*....|....*....|....*....|....*..
gi 15231353 701 TDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTAR 737
Cdd:pfam00271 71 TDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGR 107
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
387-567 |
2.15e-22 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 95.43 E-value: 2.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 387 KALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRL---REEELQGhskssPGCprvIVLVPTAEL 463
Cdd:cd17941 3 KGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLyreRWTPEDG-----LGA---LIISPTREL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 464 ASQVLANCRSISKSGVpFRSMVVTGGFRQRTQLENLEQgVDVLIATPGRFTYLMNEGI-LGLSNLRCAILDEVDILFgDD 542
Cdd:cd17941 75 AMQIFEVLRKVGKYHS-FSAGLIIGGKDVKEEKERINR-MNILVCTPGRLLQHMDETPgFDTSNLQMLVLDEADRIL-DM 151
|
170 180
....*....|....*....|....*
gi 15231353 543 EFEAALQNLINSSPVTAQYLFVTAT 567
Cdd:cd17941 152 GFKETLDAIVENLPKSRQTLLFSAT 176
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
376-572 |
4.72e-22 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 94.84 E-value: 4.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 376 FAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQ----RLREeelqghsksspgc 451
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQcldiQVRE------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 452 PRVIVLVPTAELASQVLANCRSISK-SGVPFRSMVvtGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCA 530
Cdd:cd18045 68 TQALILSPTRELAVQIQKVLLALGDyMNVQCHACI--GGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKML 145
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 15231353 531 ILDEVDILFGdDEFEAALQNLINSSPVTAQYLFVTATLPLEI 572
Cdd:cd18045 146 VLDEADEMLN-KGFKEQIYDVYRYLPPATQVVLVSATLPQDI 186
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
385-560 |
1.42e-21 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 93.92 E-value: 1.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQAMAFSPVIDGKSCI-IAdQSGSGKTLAYLVPVIQRLREEELQGHSKSSPGcPRVIVLVPTAEL 463
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIgIA-ETGSGKTAAFLIPLLVYISRLPPLDEETKDDG-PYALILAPTREL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 464 ASQVLANCRSISKsGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDILFgDDE 543
Cdd:cd17945 79 AQQIEEETQKFAK-PLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMI-DMG 156
|
170
....*....|....*..
gi 15231353 544 FEAALQNLINSSPVTAQ 560
Cdd:cd17945 157 FEPQVTKILDAMPVSNK 173
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
386-556 |
3.23e-21 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 92.25 E-value: 3.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 386 MKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreeeLQGHSKSSPGCPRVIVLVPTAELAS 465
Cdd:cd17960 2 LDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEIL----LKRKANLKKGQVGALIISPTRELAT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 466 QVLANCRSISKSGVP-FRSMVVTGGFRQRTQLENL-EQGVDVLIATPGRFTYL--MNEGILGLSNLRCAILDEVDILFgD 541
Cdd:cd17960 78 QIYEVLQSFLEHHLPkLKCQLLIGGTNVEEDVKKFkRNGPNILVGTPGRLEELlsRKADKVKVKSLEVLVLDEADRLL-D 156
|
170
....*....|....*
gi 15231353 542 DEFEAALQNLINSSP 556
Cdd:cd17960 157 LGFEADLNRILSKLP 171
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
376-572 |
1.45e-20 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 90.58 E-value: 1.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 376 FAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLrEEELQGhsksspgcPRVI 455
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI-DTSLKA--------TQAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 456 VLVPTAELASQVLancRSISKSG--VPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILD 533
Cdd:cd18046 72 VLAPTRELAQQIQ---KVVMALGdyMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLD 148
|
170 180 190
....*....|....*....|....*....|....*....
gi 15231353 534 EVDILFGDDeFEAALQNLINSSPVTAQYLFVTATLPLEI 572
Cdd:cd18046 149 EADEMLSRG-FKDQIYDIFQKLPPDTQVVLLSATMPNDV 186
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
385-568 |
6.70e-19 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 86.53 E-value: 6.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 385 MMKALKEQNFDRPAHIQA----------MAFSPVIDGKSCIIAdQSGSGKTLAYLVPVIQRLReeelqghSKSSPgCPRV 454
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAavipwllpssKSTPPYRPGDLCVSA-PTGSGKTLAYVLPIVQALS-------KRVVP-RLRA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 455 IVLVPTAELASQVLANCRSISKsGVPFRSMVVTGG--FRQRTQLE------NLEQGVDVLIATPGRftyLM-----NEGI 521
Cdd:cd17956 72 LIVVPTKELVQQVYKVFESLCK-GTGLKVVSLSGQksFKKEQKLLlvdtsgRYLSRVDILVATPGR---LVdhlnsTPGF 147
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231353 522 LgLSNLRCAILDEVDILFG-------------------DDEFEAALQNLINSSPVTAQYLFVTATL 568
Cdd:cd17956 148 T-LKHLRFLVIDEADRLLNqsfqdwletvmkalgrptaPDLGSFGDANLLERSVRPLQKLLFSATL 212
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
382-587 |
8.29e-19 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 85.32 E-value: 8.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 382 SEDMMKALKEQNFDRPAHIQAMAFsPVI--DGKSCIIAD-QSGSGKTLAYLVPVIQRLREEELqghsksspgCPRVIVLV 458
Cdd:cd17963 2 KPELLKGLYAMGFNKPSKIQETAL-PLIlsDPPENLIAQsQSGTGKTAAFVLAMLSRVDPTLK---------SPQALCLA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 459 PTAELASQVLANCRSISKsgvpFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDIL 538
Cdd:cd17963 72 PTRELARQIGEVVEKMGK----FTGVKVALAVPGNDVPRGKKITAQIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVM 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 15231353 539 FGDDEFEAALQNLINSSPVTAQYLFVTATLPLEIYNKLVEVFPDCEVVM 587
Cdd:cd17963 148 LDTQGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
411-567 |
1.96e-17 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 79.75 E-value: 1.96e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 411 GKSCIIADQSGSGKTLAYLVPVIQRLREEElqghsksspgcPRVIVLVPTAELASQVLANCRSISKSGVPFRsmVVTGGF 490
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKKG-----------KKVLVLVPTKALALQTAERLRELFGPGIRVA--VLVGGS 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15231353 491 RQRTQLENLEQGVDVLIATPGRF-TYLMNEGILGLSNLRCAILDEVD-ILFGDDEFEAALQNLINSSPVTAQYLFVTAT 567
Cdd:cd00046 68 SAEEREKNKLGDADIIIATPDMLlNLLLREDRLFLKDLKLIIVDEAHaLLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
661-737 |
2.17e-17 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 77.25 E-value: 2.17e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15231353 661 KERQLHVLPFHAALSQESRLTNMQEFtssqPEENSLFLVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTAR 737
Cdd:smart00490 8 KELGIKVARLHGGLSQEEREEILDKF----NNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
376-572 |
3.50e-17 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 80.85 E-value: 3.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 376 FAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreeelqghsKSSPGCPRVI 455
Cdd:cd17950 4 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQL---------EPVDGQVSVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 456 VLVPTAELASQVLANCRSISKSGVPFRSMVVTGGFRQRTQLENLEQGV-DVLIATPGRFTYLMNEGILGLSNLRCAILDE 534
Cdd:cd17950 75 VICHTRELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDE 154
|
170 180 190
....*....|....*....|....*....|....*...
gi 15231353 535 VDILFGDDEFEAALQNLINSSPVTAQYLFVTATLPLEI 572
Cdd:cd17950 155 CDKMLEQLDMRRDVQEIFRATPHDKQVMMFSATLSKEI 192
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
370-586 |
1.35e-15 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 76.98 E-value: 1.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 370 FFSRKTFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVI-DGKSCIIA-DQSGSGKTLAYLVPVIQRLREEELQghsks 447
Cdd:cd18048 14 LFSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLaDPPQNLIAqSQSGTGKTAAFVLAMLSRVDALKLY----- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 448 spgcPRVIVLVPTAELASQVLANCRSISKSGVPFRSMVVTGGFR--QRTQLEnleqgVDVLIATPGR-FTYLMNEGILGL 524
Cdd:cd18048 89 ----PQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRpgKGTDIE-----AQIVIGTPGTvLDWCFKLRLIDV 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15231353 525 SNLRCAILDEVDILFGDDEFEAALQNLINSSPVTAQYLFVTATLPLEIYNKLVEVFPDCEVV 586
Cdd:cd18048 160 TNISVFVLDEADVMINVQGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNII 221
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
387-750 |
1.80e-12 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 71.02 E-value: 1.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 387 KALKEQNFDRP-AHiQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEelqghskssPGCpRVIVLVPTAELAS 465
Cdd:COG1205 47 AALKKRGIERLySH-QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLED---------PGA-TALYLYPTKALAR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 466 QVLANCRS-ISKSGVPFRSMVVTGG--FRQRTQLenLEQGvDVLIATPgrftYLMNEGILG--------LSNLRCAILDE 534
Cdd:COG1205 116 DQLRRLRElAEALGLGVRVATYDGDtpPEERRWI--REHP-DIVLTNP----DMLHYGLLPhhtrwarfFRNLRYVVIDE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 535 VDI---LFGddefeAALQNLI----------NSSPvtaQYLFVTATL--PLEIYNKLVEVfpDCEVV------MGPRVHr 593
Cdd:COG1205 189 AHTyrgVFG-----SHVANVLrrlrricrhyGSDP---QFILASATIgnPAEHAERLTGR--PVTVVdedgspRGERTF- 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 594 vsnaleeFLVDCSGDDNAEKTPETAFqnkkTALL--QIMEENpvSKTIIFCNKIetcRKVENIFKRVDRKERQ----LHV 667
Cdd:COG1205 258 -------VLWNPPLVDDGIRRSALAE----AARLlaDLVREG--LRTLVFTRSR---RGAELLARYARRALREpdlaDRV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 668 LPFHAALSQESRltnmQEFtssqpeENSLF------LVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARG 741
Cdd:COG1205 322 AAYRAGYLPEER----REI------ERGLRsgellgVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQD 391
|
....*....
gi 15231353 742 kgkAFIFVV 750
Cdd:COG1205 392 ---SLVVLV 397
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
421-763 |
3.97e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 69.67 E-value: 3.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 421 GSGKTLAYLVpVIQRLREeelqghsksspgCPRVIVLVPTAELASQVLANCRSIsksgvpFRSMVVTGGFRQRTQlenle 500
Cdd:COG1061 110 GTGKTVLALA-LAAELLR------------GKRVLVLVPRRELLEQWAEELRRF------LGDPLAGGGKKDSDA----- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 501 qgvDVLIATPGRFTYLMNEGILGlSNLRCAILDEVDiLFGDDEFEAALQNLinsspvTAQYLF-VTAT--------LPLE 571
Cdd:COG1061 166 ---PITVATYQSLARRAHLDELG-DRFGLVIIDEAH-HAGAPSYRRILEAF------PAAYRLgLTATpfrsdgreILLF 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 572 IYNKLVEVFP-----DCEVVMGPRVHRVSNALEEFLVDcsgDDNAEKTPETAF----QNKKTALLQIMEENP-VSKTIIF 641
Cdd:COG1061 235 LFDGIVYEYSlkeaiEDGYLAPPEYYGIRVDLTDERAE---YDALSERLREALaadaERKDKILRELLREHPdDRKTLVF 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 642 CNKIETCRKVENIFkrvdrKERQLHVLPFHAALSQESRLTNMQEFTSSQPEenslFLVCTDRASRGIDFSGVDHVVLFDF 721
Cdd:COG1061 312 CSSVDHAEALAELL-----NEAGIRAAVVTGDTPKKEREEILEAFRDGELR----ILVTVDVLNEGVDVPRLDVAILLRP 382
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 15231353 722 PRDPSEYVRRVGRTARGARGKGKAFIF-VVGKQVGLARRIIER 763
Cdd:COG1061 383 TGSPREFIQRLGRGLRPAPGKEDALVYdFVGNDVPVLEELAKD 425
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
635-749 |
2.30e-10 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 57.33 E-value: 2.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 635 VSKTIIFCNKIETCRKVENIFKrvdrkerqlhvlpfhaalsqesrltnmqeftssqpeenslFLVCTDRASRGIDFSGVD 714
Cdd:cd18785 3 VVKIIVFTNSIEHAEEIASSLE----------------------------------------ILVATNVLGEGIDVPSLD 42
|
90 100 110
....*....|....*....|....*....|....*
gi 15231353 715 HVVLFDFPRDPSEYVRRVGRTARGARGKGKAFIFV 749
Cdd:cd18785 43 TVIFFDPPSSAASYIQRVGRAGRGGKDEGEVILFV 77
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
399-569 |
7.25e-10 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 58.81 E-value: 7.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 399 HIQAMAFSPVID-GKSCIIADQSGSGKTL-AYLVpVIQRLREEElqghsksspgcPRVIVLVPTAELASQVLANCRSISK 476
Cdd:cd17921 4 PIQREALRALYLsGDSVLVSAPTSSGKTLiAELA-ILRALATSG-----------GKAVYIAPTRALVNQKEADLRERFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 477 SGvPFRSMVVTGGFrqrTQLENLEQGVDVLIATPGRF-TYLMNEGILGLSNLRCAILDEVDILfGDDE----FEAALQNL 551
Cdd:cd17921 72 PL-GKNVGLLTGDP---SVNKLLLAEADILVATPEKLdLLLRNGGERLIQDVRLVVVDEAHLI-GDGErgvvLELLLSRL 146
|
170
....*....|....*...
gi 15231353 552 INSSPvTAQYLFVTATLP 569
Cdd:cd17921 147 LRINK-NARFVGLSATLP 163
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
374-586 |
2.50e-09 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 57.81 E-value: 2.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 374 KTFAEIGCSEDMMKALKEQNFDRPAHIQAMAFSPVI--DGKSCIIADQSGSGKTLAYLVPVIqrlreeelqghSKSSPGC 451
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLaePPQNLIAQSQSGTGKTAAFVLAML-----------SQVEPAN 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 452 --PRVIVLVPTAELAsqvLANCRSISKSGVPFRSMVVTGGFRQrtqlENLEQGV----DVLIATPGR-FTYLMNEGILGL 524
Cdd:cd18047 70 kyPQCLCLSPTYELA---LQTGKVIEQMGKFYPELKLAYAVRG----NKLERGQkiseQIVIGTPGTvLDWCSKLKFIDP 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15231353 525 SNLRCAILDEVDILF---GDDEFEAALQNLInssPVTAQYLFVTATLPLEIYNKLVEVFPDCEVV 586
Cdd:cd18047 143 KKIKVFVLDEADVMIatqGHQDQSIRIQRML---PRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
401-658 |
3.82e-08 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 56.83 E-value: 3.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 401 QAMAF-SPVIDGKSCIIADQSGSGKTL-AYLvPVIQRLREEelqghsksspgcPRVIVLVPTAELASQVLANCRS-ISKS 477
Cdd:COG1204 27 QAEALeAGLLEGKNLVVSAPTASGKTLiAEL-AILKALLNG------------GKALYIVPLRALASEKYREFKRdFEEL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 478 GVpfRSMVVTGGFRQRTqlENLEQgVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDiLFGDDE----FEAALQNLIN 553
Cdd:COG1204 94 GI--KVGVSTGDYDSDD--EWLGR-YDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAH-LIDDESrgptLEVLLARLRR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 554 SSPvTAQYLFVTATLPleiyNklVEVFP---DCEVVmgpRVHRVSNALEEFLVdcsgDDNAEKTPETAFQNKKTAL---L 627
Cdd:COG1204 168 LNP-EAQIVALSATIG----N--AEEIAewlDAELV---KSDWRPVPLNEGVL----YDGVLRFDDGSRRSKDPTLalaL 233
|
250 260 270
....*....|....*....|....*....|.
gi 15231353 628 QIMEENpvSKTIIFCNKIetcRKVENIFKRV 658
Cdd:COG1204 234 DLLEEG--GQVLVFVSSR---RDAESLAKKL 259
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
622-726 |
1.41e-07 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 50.94 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 622 KKTALLQIMEE--NPVSKTIIFCNKIETCRKVENIFKrvdrkERQLHVLPFHAALSQESRLTNMQEFtsSQPEENSLFLV 699
Cdd:cd18793 12 KLEALLELLEElrEPGEKVLIFSQFTDTLDILEEALR-----ERGIKYLRLDGSTSSKERQKLVDRF--NEDPDIRVFLL 84
|
90 100
....*....|....*....|....*..
gi 15231353 700 CTDRASRGIDFSGVDHVVLFDFPRDPS 726
Cdd:cd18793 85 STKAGGVGLNLTAANRVILYDPWWNPA 111
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
401-534 |
8.70e-07 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 50.12 E-value: 8.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 401 QAMAFSPVIDGKSCIIADQSGSGKTLAYLVpviqrLREEELQGHSKSSPGcpRVIVLVPTAELASQVLANCRSISKSgVP 480
Cdd:cd17927 7 QLELAQPALKGKNTIICLPTGSGKTFVAVL-----ICEHHLKKFPAGRKG--KVVFLANKVPLVEQQKEVFRKHFER-PG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 15231353 481 FRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEGIL-GLSNLRCAILDE 534
Cdd:cd17927 79 YKVTGLSGDTSENVSVEQIVESSDVIIVTPQILVNDLKSGTIvSLSDFSLLVFDE 133
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
398-534 |
9.45e-07 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 49.89 E-value: 9.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 398 AHiQAMAFSPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEelqghskssPGcPRVIVLVPTAELASQVLANCRS-ISK 476
Cdd:cd17923 3 SH-QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRD---------PG-SRALYLYPTKALAQDQLRSLRElLEQ 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15231353 477 SGVPFRSMVVTGGFRQRTQLENLEQGVDVLIATPGRFTYLM----NEGILGLSNLRCAILDE 534
Cdd:cd17923 72 LGLGIRVATYDGDTPREERRAIIRNPPRILLTNPDMLHYALlphhDRWARFLRNLRYVVLDE 133
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
421-535 |
4.46e-06 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 48.03 E-value: 4.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 421 GSGKTL-AYLVpviqrLREEELQGHSKSSPGCpRVIVLVPTAELASQvlaNCRSIsKSGVPFRSMVVTGG-----FRQRT 494
Cdd:cd18034 26 GSGKTLiAVML-----IKEMGELNRKEKNPKK-RAVFLVPTVPLVAQ---QAEAI-RSHTDLKVGEYSGEmgvdkWTKER 95
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 15231353 495 QLENLEQgVDVLIATPGRFTYLMNEGILGLSNLRCAILDEV 535
Cdd:cd18034 96 WKEELEK-YDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
411-571 |
2.19e-05 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 45.65 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 411 GKSCIIADQSGSGKTLAYLVPVIQRLREEELQGhsksspgcPRVIVLVPTAELASQVLANCRSISKSGVPFRSMVV-TG- 488
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKG--------VQVLYISPLKALINDQERRLEEPLDEIDLEIPVAVrHGd 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 489 ---GFRQRtQLENLEqgvDVLIATPGRFTYLM-NEGILG-LSNLRCAILDEVDILFGDD---EFEAALQNLINSSPVTAQ 560
Cdd:cd17922 73 tsqSEKAK-QLKNPP---GILITTPESLELLLvNKKLRElFAGLRYVVVDEIHALLGSKrgvQLELLLERLRKLTGRPLR 148
|
170
....*....|..
gi 15231353 561 YLFVTATL-PLE 571
Cdd:cd17922 149 RIGLSATLgNLE 160
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
625-722 |
2.20e-05 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 47.91 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 625 ALLQIMEENPVS--KTIIFCNKIETCRKVENIFKrvdrkERQLHVLPFHAALSQESRLTNMQEFTssQPEENSLFLVCTD 702
Cdd:COG0553 537 ALLELLEELLAEgeKVLVFSQFTDTLDLLEERLE-----ERGIEYAYLHGGTSAEERDELVDRFQ--EGPEAPVFLISLK 609
|
90 100
....*....|....*....|
gi 15231353 703 RASRGIDFSGVDHVVLFDFP 722
Cdd:COG0553 610 AGGEGLNLTAADHVIHYDLW 629
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
408-535 |
8.81e-05 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 44.68 E-value: 8.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 408 VIDGKSCIIADQSGSGKT---LAYLVPVIQ---------RLREEELQGHSKSSPGcPRVIVLVPTAelasqVLANCRS-I 474
Cdd:cd18005 16 YKNGRGGILGDDMGLGKTvqvIAFLAAVLGktgtrrdreNNRPRFKKKPPASSAK-KPVLIVAPLS-----VLYNWKDeL 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15231353 475 SKSGvPFRSMVVTGGFRQRTQLENLEQG-VDVLIATpgrFTYLMNEgILGLSNLR--CAILDEV 535
Cdd:cd18005 90 DTWG-HFEVGVYHGSRKDDELEGRLKAGrLEVVVTT---YDTLRRC-IDSLNSINwsAVIADEA 148
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
378-568 |
2.59e-04 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 44.42 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 378 EIGCSEDMMKALKEQNFDRPAHIQAMAF-SPVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEElqghsksspgcPRVIV 456
Cdd:PRK00254 5 ELRVDERIKRVLKERGIEELYPPQAEALkSGVLEGKNLVLAIPTASGKTLVAEIVMVNKLLREG-----------GKAVY 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 457 LVPTAELASQVLANCRSISKSGVpfRSMVVTGGFRQRtqlENLEQGVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVD 536
Cdd:PRK00254 74 LVPLKALAEEKYREFKDWEKLGL--RVAMTTGDYDST---DEWLGKYDIIIATAEKFDSLLRHGSSWIKDVKLVVADEIH 148
|
170 180 190
....*....|....*....|....*....|..
gi 15231353 537 iLFGDDEFEAALQNLINSSPVTAQYLFVTATL 568
Cdd:PRK00254 149 -LIGSYDRGATLEMILTHMLGRAQILGLSATV 179
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
616-734 |
3.50e-04 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 43.98 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 616 ETAFQNKKTALLQIMEENPVSKTIIFCNkieTCRKVENIFKRVdrKERQLHVLPFHAALSQESRLTNMQEFTssqpEENS 695
Cdd:COG0514 211 PKPPDDKLAQLLDFLKEHPGGSGIVYCL---SRKKVEELAEWL--REAGIRAAAYHAGLDAEEREANQDRFL----RDEV 281
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 15231353 696 LFLVCTdraSR---GIDFSGVDHVVLFDFPRDPSEYVRRVGR 734
Cdd:COG0514 282 DVIVAT---IAfgmGIDKPDVRFVIHYDLPKSIEAYYQEIGR 320
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
411-534 |
3.59e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 42.17 E-value: 3.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 411 GKSCIIADQSGSGKTL---AYlvpviqrlreeeLQGHSKSSPGCPRVIVLVPTAelasqVLAN-CRSISKSGVPFRSMVV 486
Cdd:cd17919 19 GPGGILADEMGLGKTLqaiAF------------LAYLLKEGKERGPVLVVCPLS-----VLENwEREFEKWTPDLRVVVY 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 15231353 487 TGGFRQRTQLENLEQGV--DVLIATpgrFTYLMNE-GILGLSNLRCAILDE 534
Cdd:cd17919 82 HGSQRERAQIRAKEKLDkfDVVLTT---YETLRRDkASLRKFRWDLVVVDE 129
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
421-534 |
3.62e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 42.02 E-value: 3.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 421 GSGKTLAYLVPVIQRLREEElqghsksspgcpRVIVLVPTAELASQVLANCRsisKSGVPFRSMVVTGGFRqrtqlENLE 500
Cdd:cd17918 46 GSGKTLVALGAALLAYKNGK------------QVAILVPTEILAHQHYEEAR---KFLPFINVELVTGGTK-----AQIL 105
|
90 100 110
....*....|....*....|....*....|....
gi 15231353 501 QGVDVLIATpgrfTYLMNEGILGLsNLRCAILDE 534
Cdd:cd17918 106 SGISLLVGT----HALLHLDVKFK-NLDLVIVDE 134
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
401-569 |
5.57e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 41.55 E-value: 5.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 401 QAMAF-SPVIDGKSCIIADQSGSGKTLAYLVPVIQRLreeeLQGHsksspgcpRVIVLVPTAELASQVLANCRSISKSGV 479
Cdd:cd18028 6 QAEAVrAGLLKGENLLISIPTASGKTLIAEMAMVNTL----LEGG--------KALYLVPLRALASEKYEEFKKLEEIGL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 480 pfRSMVVTGGFRQRTqlENLEQgVDVLIATPGRFTYLMNEGILGLSNLRCAILDEVDiLFGDDE----FEAALQNLINSS 555
Cdd:cd18028 74 --KVGISTGDYDEDD--EWLGD-YDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIH-LISDEErgptLESIVARLRRLN 147
|
170
....*....|....
gi 15231353 556 PvTAQYLFVTATLP 569
Cdd:cd18028 148 P-NTQIIGLSATIG 160
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
511-743 |
1.41e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 41.65 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 511 GRFTYLMNegiLGLSNLrcaILDEVDILfgDDE----FEAALQNLI-NSSPVtaqyLFVTATLPleiyNKLVEVFPDCEV 585
Cdd:cd09639 114 HYEFTLAS---IANSLL---IFDEVHFY--DEYtlalILAVLEVLKdNDVPI----LLMSATLP----KFLKEYAEKIGY 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 586 VMGPRVHRVSNALEEFLVDCSGDDNAEktpetafQNKKTALLQimEENPVSKTIIFCNKIETCRKvenIFKRVDRKERQL 665
Cdd:cd09639 178 VEENEPLDLKPNERAPFIKIESDKVGE-------ISSLERLLE--FIKKGGSVAIIVNTVDRAQE---FYQQLKEKGPEE 245
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15231353 666 HVLPFHAALSQESRLTNMQEFTSSQPEENSLFLVCTDRASRGIDFSgVDhvVLFDFPRDPSEYVRRVGRTARGARGKG 743
Cdd:cd09639 246 EIMLIHSRFTEKDRAKKEAELLLEFKKSEKFVIVATQVIEASLDIS-VD--VMITELAPIDSLIQRLGRLHRYGEKNG 320
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
636-749 |
2.05e-03 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 39.55 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 636 SKTIIFCNkieTCRKVENIFKRV-DRKERQLHVLPF---HAALSQESRLTnmqeftssqpEENSL------FLVCTDRAS 705
Cdd:cd18796 39 KSTLVFTN---TRSQAERLAQRLrELCPDRVPPDFIalhHGSLSRELREE----------VEAALkrgdlkVVVATSSLE 105
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 15231353 706 RGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARGKGKAFIFV 749
Cdd:cd18796 106 LGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGAASKGRLVP 149
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
393-538 |
2.16e-03 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 40.03 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 393 NFDRpahIQAMAFSPVIDG-KSCIIADQSGSGKT----LAYLvpviqRLreeeLQGHSKSSPGCPRVIVLVPTAELASQV 467
Cdd:cd18023 1 YFNR---IQSEVFPDLLYSdKNFVVSAPTGSGKTvlfeLAIL-----RL----LKERNPLPWGNRKVVYIAPIKALCSEK 68
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15231353 468 LANCR-SISKSGVPFrsMVVTGGfrqrTQLENLE--QGVDVLIATPGRF---TYLMNEGILGLSNLRCAILDEVDIL 538
Cdd:cd18023 69 YDDWKeKFGPLGLSC--AELTGD----TEMDDTFeiQDADIILTTPEKWdsmTRRWRDNGNLVQLVALVLIDEVHII 139
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| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
407-535 |
2.29e-03 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 40.15 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 407 PVIDGKSCIIADQSGSGKTLAYLVPVIQRLREEELQGHskssPGcpRVIVLVPTAELASQVLancrsiSKSGVPFRSMV- 485
Cdd:cd18036 13 PALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAGE----KG--RVVVLVNKVPLVEQQL------EKFFKYFRKGYk 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15231353 486 ---VTGGFRQRTQLENLEQGVDVLIATPGRFTYLMNEG----ILGLSNLRCAILDEV 535
Cdd:cd18036 81 vtgLSGDSSHKVSFGQIVKASDVIICTPQILINNLLSGreeeRVYLSDFSLLIFDEC 137
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
622-750 |
2.66e-03 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 38.73 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 622 KKTALLQIM----EENPVSKTIIFCNKIETCRKVENIFKRVDRKERQLHVlpfhAALSQESRLTNMQEFTSSQPEEN--- 694
Cdd:cd18802 8 KLQKLIEILreyfPKTPDFRGIIFVERRATAVVLSRLLKEHPSTLAFIRC----GFLIGRGNSSQRKRSLMTQRKQKetl 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15231353 695 SLF-------LVCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRtargARGKGKAFIFVV 750
Cdd:cd18802 84 DKFrdgelnlLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR----ARAPNSKYILMV 142
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|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
627-742 |
4.74e-03 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 38.11 E-value: 4.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 627 LQIMEENPVSKTIIFCNKIETcrkVENIFKRVDRKERQLHVLPF--HAA------LSQESRLTNMQEFtssQPEENSLfL 698
Cdd:cd18801 22 FKKKQEGSDTRVIIFSEFRDS---AEEIVNFLSKIRPGIRATRFigQASgksskgMSQKEQKEVIEQF---RKGGYNV-L 94
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 15231353 699 VCTDRASRGIDFSGVDHVVLFDFPRDPSEYVRRVGRTARGARGK 742
Cdd:cd18801 95 VATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGRKRQGR 138
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|
| PRK12678 |
PRK12678 |
transcription termination factor Rho; Provisional |
164-328 |
6.87e-03 |
|
transcription termination factor Rho; Provisional
Pssm-ID: 237171 [Multi-domain] Cd Length: 672 Bit Score: 39.89 E-value: 6.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 164 KAIPRSGKSAERNEVKRASKVRESRESRRDLDRLEGDDEDVDEVSNPDRFTDNQRAGSRSSYSKGGYAANSRGKGDRLSV 243
Cdd:PRK12678 111 AAAAAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGER 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231353 244 ARDLDSFEGHGRAIDE-VSNPRKFNDNERAESRSSYSRDSSANSRGREDRRFVAKELDTFQGRDKAYDEVYNPRRFTDNE 322
Cdd:PRK12678 191 GRREERGRDGDDRDRRdRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDGEGRGGRRGRRFRDRD 270
|
....*.
gi 15231353 323 RGLRGG 328
Cdd:PRK12678 271 RRGRRG 276
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