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Conserved domains on  [gi|240255311|ref|NP_187612|]
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demeter-like 2 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRM_DME pfam15628
RRM in Demeter; This is a predicted RRM-fold domain present at the C-terminus of Demeter-like ...
 1219-1320 7.57e-62

RRM in Demeter; This is a predicted RRM-fold domain present at the C-terminus of Demeter-like glycoslyases. These proteins are involved in DNA demethylation in plants where they catalyze removal of the 5mC base and subsequently cleave the backbone through lyase activity. Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic domain with ssDNA or regulatory RNA.


:

Pssm-ID: 373977  Cd Length: 102  Bit Score: 205.68  E-value: 7.57e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  1219 GTILIPCRTAMRGGFPLNGTYFQTNEVFADHDSSINPIDVPTELIWDLKRRVAYLGSSVSSICKGLSVEAIKYNFQEGYV 1298
Cdd:pfam15628    1 GTILIPCRTAMRGSFPLNGTYFQVNEVFADHESSLNPIVVPRELIWNLPRRIVYFGTSVPSIFKGLSTEEIQQCFWKGFV 80

                           90       100
                   ....*....|....*....|..
gi 240255311  1299 CVRGFDRENRKPKSLVKRLHCS 1320
Cdd:pfam15628   81 CVRGFDRKTRAPKPLVARLHAP 102
Nth COG0177
Endonuclease III [Replication, recombination and repair];
816-989 1.24e-28

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 114.42  E-value: 1.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  816 DWDALRCTDVHKIANIIIKRGMNNMLAERIKAFLNRLVKKHGSidlewlrDVPpdKAKEYLLSINGLGLKSVECVRLLSL 895
Cdd:COG0177    51 TPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGG-------EVP--ETREELESLPGVGRKTANVVLNFAF 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  896 HQIAFPVDTNVGRIAVRLGWVPLQPlPDELQMHLLELYPvlesvqkylwprlckldQKTLYELHYHMITFGKVFCTKVKP 975
Cdd:COG0177   122 GKPAIAVDTHVHRVSNRLGLVPGKD-PEEVEKDLMKLIP-----------------KEYWGDLHHLLILHGRYICKARKP 183

                         170
                  ....*....|....
gi 240255311  976 NCNACPMKAECRHY 989
Cdd:COG0177   184 KCEECPLADLCPYY 197
Perm-CXXC pfam15629
Permuted single zf-CXXC unit; This is a permuted version of a single unit of the zf-CXXC ...
 1184-1216 8.77e-10

Permuted single zf-CXXC unit; This is a permuted version of a single unit of the zf-CXXC domain that is detected in the Demeter-like proteins of land plants. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.


:

Pssm-ID: 434822  Cd Length: 32  Bit Score: 55.09  E-value: 8.77e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 240255311  1184 PKQRCAlFESNNTLCNENKCFQCNKTREEESQT 1216
Cdd:pfam15629    1 PERKCN-SQESGKLCNEETCFSCNSIREANSQT 32
 
Name Accession Description Interval E-value
RRM_DME pfam15628
RRM in Demeter; This is a predicted RRM-fold domain present at the C-terminus of Demeter-like ...
 1219-1320 7.57e-62

RRM in Demeter; This is a predicted RRM-fold domain present at the C-terminus of Demeter-like glycoslyases. These proteins are involved in DNA demethylation in plants where they catalyze removal of the 5mC base and subsequently cleave the backbone through lyase activity. Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic domain with ssDNA or regulatory RNA.


Pssm-ID: 373977  Cd Length: 102  Bit Score: 205.68  E-value: 7.57e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  1219 GTILIPCRTAMRGGFPLNGTYFQTNEVFADHDSSINPIDVPTELIWDLKRRVAYLGSSVSSICKGLSVEAIKYNFQEGYV 1298
Cdd:pfam15628    1 GTILIPCRTAMRGSFPLNGTYFQVNEVFADHESSLNPIVVPRELIWNLPRRIVYFGTSVPSIFKGLSTEEIQQCFWKGFV 80

                           90       100
                   ....*....|....*....|..
gi 240255311  1299 CVRGFDRENRKPKSLVKRLHCS 1320
Cdd:pfam15628   81 CVRGFDRKTRAPKPLVARLHAP 102
Nth COG0177
Endonuclease III [Replication, recombination and repair];
816-989 1.24e-28

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 114.42  E-value: 1.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  816 DWDALRCTDVHKIANIIIKRGMNNMLAERIKAFLNRLVKKHGSidlewlrDVPpdKAKEYLLSINGLGLKSVECVRLLSL 895
Cdd:COG0177    51 TPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGG-------EVP--ETREELESLPGVGRKTANVVLNFAF 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  896 HQIAFPVDTNVGRIAVRLGWVPLQPlPDELQMHLLELYPvlesvqkylwprlckldQKTLYELHYHMITFGKVFCTKVKP 975
Cdd:COG0177   122 GKPAIAVDTHVHRVSNRLGLVPGKD-PEEVEKDLMKLIP-----------------KEYWGDLHHLLILHGRYICKARKP 183

                         170
                  ....*....|....
gi 240255311  976 NCNACPMKAECRHY 989
Cdd:COG0177   184 KCEECPLADLCPYY 197
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 819-967 1.64e-16

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 78.07  E-value: 1.64e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311    819 ALRCTDVHKIANIIIKRGMNNMLAERIKAFLNRLVKKHGSidlewlrdVPPDKAKEyLLSINGLGLKSVECVRLLSLHQI 898
Cdd:smart00478   26 DLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGG--------EVPDDREE-LLKLPGVGRKTANAVLSFALGKP 96

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 240255311    899 AFPVDTNVGRIAVRLGWVPLQPLPDELQMHLLELYPvlesvqkylwprlckldQKTLYELHYHMITFGK 967
Cdd:smart00478   97 FIPVDTHVLRIAKRLGLVDKKSTPEEVEKLLEKLLP-----------------EEDWRELNLLLIDFGR 148
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 816-934 1.22e-15

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 75.74  E-value: 1.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  816 DWDALRCTDVHKIANIIIKRGMNNMlAERIKAFLNRLVKKHGSIDLewlrdvPPDKAKEYLLSINGLGLKSVECVRLLSL 895
Cdd:cd00056    32 TPEALAAADEEELRELIRSLGYRRK-AKYLKELARAIVEGFGGLVL------DDPDAREELLALPGVGRKTANVVLLFAL 104

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 240255311  896 HQIAFPVDTNVGRIAVRLGWVPLQPLPDELQMHLLELYP 934
Cdd:cd00056   105 GPDAFPVDTHVRRVLKRLGLIPKKKTPEELEELLEELLP 143
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 818-934 1.66e-10

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 60.38  E-value: 1.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311   818 DALRCTDVHKIANIIIKRGMNNMLAERIKAFLNRLVKKHGSIDlewlrdvpPDKAKEYLLSINGLGLKSVECVRLLSLH- 896
Cdd:pfam00730   30 EDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEV--------PLDEEELEALLKGVGRWTAEAVLIFALGr 101

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 240255311   897 -QIAFPVDTNVGRIAVRLGWVPLQPLPDELQMHLLELYP 934
Cdd:pfam00730  102 pDPLPVVDTHVRRVLKRLGLIKEKPTPKEVERELEELWP 140
Perm-CXXC pfam15629
Permuted single zf-CXXC unit; This is a permuted version of a single unit of the zf-CXXC ...
 1184-1216 8.77e-10

Permuted single zf-CXXC unit; This is a permuted version of a single unit of the zf-CXXC domain that is detected in the Demeter-like proteins of land plants. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.


Pssm-ID: 434822  Cd Length: 32  Bit Score: 55.09  E-value: 8.77e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 240255311  1184 PKQRCAlFESNNTLCNENKCFQCNKTREEESQT 1216
Cdd:pfam15629    1 PERKCN-SQESGKLCNEETCFSCNSIREANSQT 32
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 855-912 2.89e-05

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 47.60  E-value: 2.89e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 240255311   855 KHGSIDLEWLRDVPPDKAKEYLLSINGLGLKSVECVRLLSLHQI-AFPVDTNVGRIAVR 912
Cdd:TIGR00588  201 QGGRAWLQQIRGASYEDAREALCELPGVGPKVADCICLMGLDKPqAVPVDVHVWRIANR 259
 
Name Accession Description Interval E-value
RRM_DME pfam15628
RRM in Demeter; This is a predicted RRM-fold domain present at the C-terminus of Demeter-like ...
 1219-1320 7.57e-62

RRM in Demeter; This is a predicted RRM-fold domain present at the C-terminus of Demeter-like glycoslyases. These proteins are involved in DNA demethylation in plants where they catalyze removal of the 5mC base and subsequently cleave the backbone through lyase activity. Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic domain with ssDNA or regulatory RNA.


Pssm-ID: 373977  Cd Length: 102  Bit Score: 205.68  E-value: 7.57e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  1219 GTILIPCRTAMRGGFPLNGTYFQTNEVFADHDSSINPIDVPTELIWDLKRRVAYLGSSVSSICKGLSVEAIKYNFQEGYV 1298
Cdd:pfam15628    1 GTILIPCRTAMRGSFPLNGTYFQVNEVFADHESSLNPIVVPRELIWNLPRRIVYFGTSVPSIFKGLSTEEIQQCFWKGFV 80

                           90       100
                   ....*....|....*....|..
gi 240255311  1299 CVRGFDRENRKPKSLVKRLHCS 1320
Cdd:pfam15628   81 CVRGFDRKTRAPKPLVARLHAP 102
Nth COG0177
Endonuclease III [Replication, recombination and repair];
816-989 1.24e-28

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 114.42  E-value: 1.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  816 DWDALRCTDVHKIANIIIKRGMNNMLAERIKAFLNRLVKKHGSidlewlrDVPpdKAKEYLLSINGLGLKSVECVRLLSL 895
Cdd:COG0177    51 TPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGG-------EVP--ETREELESLPGVGRKTANVVLNFAF 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  896 HQIAFPVDTNVGRIAVRLGWVPLQPlPDELQMHLLELYPvlesvqkylwprlckldQKTLYELHYHMITFGKVFCTKVKP 975
Cdd:COG0177   122 GKPAIAVDTHVHRVSNRLGLVPGKD-PEEVEKDLMKLIP-----------------KEYWGDLHHLLILHGRYICKARKP 183

                         170
                  ....*....|....
gi 240255311  976 NCNACPMKAECRHY 989
Cdd:COG0177   184 KCEECPLADLCPYY 197
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 816-990 6.19e-18

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 84.13  E-value: 6.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  816 DWDALRCTDVHKIANIIIKRGMNNMLAERIKAFLNRLVKKHGSiDLEWLRDVPPDKAKEYLLSINGLGLKSVECVRLLSL 895
Cdd:COG2231    61 DPEALAALDPEELAELIRPSGFYNQKAKRLKNLARWLVERYGG-GLEKLKALPTEELREELLSLKGIGPETADSILLYAF 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  896 HQIAFPVDTNVGRIAVRLGWVPLQPLPDELQMHLLELYPvlesvqkylwprlckLDQKTLYELHYHMITFGKVFCTKvKP 975
Cdd:COG2231   140 NRPVFVVDAYTRRIFSRLGLIEEDASYDELQRLFEENLP---------------PDVALYNEFHALIVEHGKEYCKK-KP 203

                         170
                  ....*....|....*
gi 240255311  976 NCNACPMKAECRHYS 990
Cdd:COG2231   204 KCEECPLRDLCPYGG 218
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 819-967 1.64e-16

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 78.07  E-value: 1.64e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311    819 ALRCTDVHKIANIIIKRGMNNMLAERIKAFLNRLVKKHGSidlewlrdVPPDKAKEyLLSINGLGLKSVECVRLLSLHQI 898
Cdd:smart00478   26 DLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGG--------EVPDDREE-LLKLPGVGRKTANAVLSFALGKP 96

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 240255311    899 AFPVDTNVGRIAVRLGWVPLQPLPDELQMHLLELYPvlesvqkylwprlckldQKTLYELHYHMITFGK 967
Cdd:smart00478   97 FIPVDTHVLRIAKRLGLVDKKSTPEEVEKLLEKLLP-----------------EEDWRELNLLLIDFGR 148
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 816-934 1.22e-15

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 75.74  E-value: 1.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  816 DWDALRCTDVHKIANIIIKRGMNNMlAERIKAFLNRLVKKHGSIDLewlrdvPPDKAKEYLLSINGLGLKSVECVRLLSL 895
Cdd:cd00056    32 TPEALAAADEEELRELIRSLGYRRK-AKYLKELARAIVEGFGGLVL------DDPDAREELLALPGVGRKTANVVLLFAL 104

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 240255311  896 HQIAFPVDTNVGRIAVRLGWVPLQPLPDELQMHLLELYP 934
Cdd:cd00056   105 GPDAFPVDTHVRRVLKRLGLIPKKKTPEELEELLEELLP 143
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 818-934 1.66e-10

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 60.38  E-value: 1.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311   818 DALRCTDVHKIANIIIKRGMNNMLAERIKAFLNRLVKKHGSIDlewlrdvpPDKAKEYLLSINGLGLKSVECVRLLSLH- 896
Cdd:pfam00730   30 EDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEV--------PLDEEELEALLKGVGRWTAEAVLIFALGr 101

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 240255311   897 -QIAFPVDTNVGRIAVRLGWVPLQPLPDELQMHLLELYP 934
Cdd:pfam00730  102 pDPLPVVDTHVRRVLKRLGLIKEKPTPKEVERELEELWP 140
Perm-CXXC pfam15629
Permuted single zf-CXXC unit; This is a permuted version of a single unit of the zf-CXXC ...
 1184-1216 8.77e-10

Permuted single zf-CXXC unit; This is a permuted version of a single unit of the zf-CXXC domain that is detected in the Demeter-like proteins of land plants. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.


Pssm-ID: 434822  Cd Length: 32  Bit Score: 55.09  E-value: 8.77e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 240255311  1184 PKQRCAlFESNNTLCNENKCFQCNKTREEESQT 1216
Cdd:pfam15629    1 PERKCN-SQESGKLCNEETCFSCNSIREANSQT 32
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 857-944 2.66e-05

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 47.19  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240255311  857 GSIDLEWLRDVPPDKAKEYLLSINGLGLKSVECVRLLSLHQI-AFPV-DTNVGRIAVRLGWVPLQPLPDELQmHLLELY- 933
Cdd:COG0122   164 GELDLEALAGLDDEEAIARLTALPGIGPWTAEMVLLFALGRPdAFPAgDLGLRRALGRLYGLGERPTPKELR-ELAEPWr 242

                          90
                  ....*....|..
gi 240255311  934 PvLESV-QKYLW 944
Cdd:COG0122   243 P-YRSYaARYLW 253
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 855-912 2.89e-05

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 47.60  E-value: 2.89e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 240255311   855 KHGSIDLEWLRDVPPDKAKEYLLSINGLGLKSVECVRLLSLHQI-AFPVDTNVGRIAVR 912
Cdd:TIGR00588  201 QGGRAWLQQIRGASYEDAREALCELPGVGPKVADCICLMGLDKPqAVPVDVHVWRIANR 259
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 969-989 3.25e-04

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 39.07  E-value: 3.25e-04
                            10        20
                    ....*....|....*....|.
gi 240255311    969 FCTKVKPNCNACPMKAECRHY 989
Cdd:smart00525    1 ICTARKPRCDECPLKDLCPAY 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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