forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 181 LLFNEPPEARKPSERWRLYVFKDGEPLNEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKEKPDGMMGK 260
Cdd:cd22719   1 LLFVEPPEARKPSKRWRLYVFKDGEPLNEPLHIHRQSCYLFGRERKVADIPTDHPSCSKQHAVIQYRLTEKEGGDGMMGK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15232296 261 QVKPYIMDLGSTNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLLHE 310
Cdd:cd22719  81 AVRPYIMDLGSTNGTFLNGERIEPQRYYELLEKDTIKFGNSSREYVLLHE 130

forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 181 LLFNEPPEARKPSERWRLYVFKDGEPLNEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKEKPDGMMGK 260
Cdd:cd22719   1 LLFVEPPEARKPSKRWRLYVFKDGEPLNEPLHIHRQSCYLFGRERKVADIPTDHPSCSKQHAVIQYRLTEKEGGDGMMGK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15232296 261 QVKPYIMDLGSTNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLLHE 310
Cdd:cd22719  81 AVRPYIMDLGSTNGTFLNGERIEPQRYYELLEKDTIKFGNSSREYVLLHE 130

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 195 RWRLyVFKDGEPLNEPLCLHRQScYLFGRERRiADIPTDHPSCSKQHAVIQYRemekekpdgmmGKQVkpYIMDLGSTNK 274
Cdd:COG1716   1 MARL-VVLEGPLAGRRFPLDGGP-LTIGRAPD-NDIVLDDPTVSRRHARIRRD-----------GGGW--VLEDLGSTNG 64

                        90       100       110
                ....*....|....*....|....*....|...
gi 15232296 275 TYINESPIepQRYYELFEKDTIKFGNSSREYVL 307
Cdd:COG1716  65 TFVNGQRV--TEPAPLRDGDVIRLGKTELRFRL 95

forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 181 LLFNEPPEARKPSERWRLYVFKDGEPLNEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKEKPDGMMGK 260
Cdd:cd22719   1 LLFVEPPEARKPSKRWRLYVFKDGEPLNEPLHIHRQSCYLFGRERKVADIPTDHPSCSKQHAVIQYRLTEKEGGDGMMGK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15232296 261 QVKPYIMDLGSTNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLLHE 310
Cdd:cd22719  81 AVRPYIMDLGSTNGTFLNGERIEPQRYYELLEKDTIKFGNSSREYVLLHE 130

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 196 WRLYVFKDGEPLnEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKEKPDGmMGKQVKPYIMDLGSTNKT 275
Cdd:cd22676   1 WRLYVFKGGEQL-ETIDIHRQSAYLIGRDRRVADIPLDHPSCSKQHAVIQFREVEKRNEGD-VIENIRPYIIDLGSTNGT 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 15232296 276 YINESPIEPQRYYELFEKDTIKFGNSSREYVLL 308
Cdd:cd22676  79 FLNGEKIEPRRYYELREKDVLKFGLSTREYVLL 111

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 191 KPSERWRLYVFKDGEpLNEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKekpdgmmgkqvKPYIMDLG 270
Cdd:cd22674   2 KPPPGLHLDVVKDGK-LIEKLMIDEKKYYLFGRNSDVCDFVLDHPSCSRVHAALVYHKHLN-----------RVFLIDLG 69

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15232296 271 STNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVL 307
Cdd:cd22674  70 STHGTFVGGIRLEPHKPQQLPIDSTLRFGASTRRYIL 106

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296   219 YLFGRERRiADIPTDHPSCSKQHAVIQYREmekekpdgmmgkQVKPYIMDLGSTNKTYINESPIEPQrYYELFEKDTIKF 298
Cdd:pfam00498   1 VTIGRSPD-CDIVLDDPSVSRRHAEIRYDG------------GGRFYLEDLGSTNGTFVNGQRLGPE-PVRLKDGDVIRL 66

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 198 LYVFKDGEPLnEPLCLHRQSCYLFGRERRI------ADIPTDHPSCSKQHAVIQYREmekekpdgmmgKQVKPYIMDLGS 271
Cdd:cd22691   4 LTVLKNGSVL-KNIFLHGKFSKSEEEDILVvgrhpdCDIVLDHPSISRFHLEIRIIP-----------SRRKITLTDLSS 71

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15232296 272 TNKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLL 308
Cdd:cd22691  72 VHGTWVNGQRIEPGVPVELEEGDTVRLGASTRVYRLH 108

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15232296 229 DIPTDHPSCSKQHAVIQYREMEkekpdgmmgkqvkPYIMDLGSTNKTYINES-PIEPQRYYELFEKDTIKFGN 300
Cdd:cd22665  32 SVVLPDKSVSKQHACIEVDGGT-------------HLIEDLGSTNGTRIGNKvRLKPNVRYELIDGDLLLFGD 91

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 213 LHR--QSCYLFGRERriADIPTDHPSCSKQHAVIQYREMEKEKpdgmmgkqvkpYIMDLGSTNKTYINESPIEPQRYYEL 290
Cdd:cd22704  11 RHRlpRSMLFVGRED--CDLILQSRSVDKQHAVITYDQIDNEF-----------KIKDLGSLNGTFVNDSRIPEQTYITL 77

                        90
                ....*....|....*..
gi 15232296 291 FEKDTIKFGNSSREYVL 307
Cdd:cd22704  78 KLGDSIRFGYDTNVYRF 94

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa protein B (Cep170B) and similar proteins; Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 215 RQSCYLFGRERriadiptdhpSCSKQHAVIQYREMEKEKpdgmmgkqvkpYIMDLGSTNKTYINESPIEPQRYYELFEKD 294
Cdd:cd22725  27 REDCELMLQSR----------SVDKQHAVINYDQDTDEH-----------WVKDLGSLNGTFVNDVRIPDQKYITLKLND 85

                        90
                ....*....|...
gi 15232296 295 TIKFGNSSREYVL 307
Cdd:cd22725  86 VIRFGYDSNMYVL 98

forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Chlamydia trachomatis Ct664 protein. Ct664 situates within the type III secretion system cluster that also encodes an STPK (CT673 in C. trachomatis), suggesting a role of CT664 in the chlamydial type III secretion system by mediating phosphorylation-dependent protein-protein interactions. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 213 LHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREmekekpDGMMgkqvkpYIMDLGSTNKTYINESPIEPQryYELFE 292
Cdd:cd22696  17 LESGKTYFIGKDPTVCDIVLQDPSISRQHARLSIDQ------DNRV------FIEDLSSKNGVLVNGKPIEGK--EEISG 82

                        90
                ....*....|
gi 15232296 293 KDTIKFGNSS 302
Cdd:cd22696  83 SDVISLGTTS 92

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa (Cep170) and similar proteins; Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15232296 236 SCSKQHAVIQYREMEKEKpdgmmgkQVKpyimDLGSTNKTYINESPIEPQRYYELFEKDTIKFG 299
Cdd:cd22724  38 SVDKQHAVINYDASTDEH-------KVK----DLGSLNGTFVNDVRIPEQTYITLKLDDKLRFG 90

forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 (AtPP2C70) and similar proteins; AtPP2C70, also called kinase-associated protein phosphatase, or protein ROOT ATTENUATED GROWTH 1, dephosphorylates the serine/threonine receptor-like kinase RLK5. It may function as a signaling component in a pathway involving RLK5. It acts as a negative regulator of the CLAVATA1 signaling in plant development by binding and dephosphorylating CLAVATA1. It is also a component of a signaling pathway which mediates adaptation to NaCl stress. It contains an FHA domain, which is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 222 GRERRiADIPTDHPSCSKQHAVIQYREMEKekpdgmmgkqvKPYIMDLGSTNKTYINESPIEPQ-RYYELFEKDTIKFGN 300
Cdd:cd22678  28 GRIQR-GDIALKDDEVSGKHARIEWNSTGS-----------KWELVDLGSLNGTLVNGESISPNgRPVVLSSGDVITLGS 95

                ....*.
gi 15232296 301 SSREYV 306
Cdd:cd22678  96 ETKILV 101

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15232296 229 DIPTDHPSCSKQHAVIQYREMEKekpdgmmgkqvkpYIMDLGSTNKTYINE-SPIEPQryYELFEKDTIKFGNSSR 303
Cdd:cd22680  32 VIVIPDPFVSRNHARITVDSNEI-------------YIEDLGSTNGTFVNDfKRIKGP--AKLHPNDIIKLGRTTV 92

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15232296 196 WRLYVFKDGEPLNEPLCLHRQSCYL-FGRERRIADIPtdhpSCSKQHAVIQYREMEK--EKPDGmmGKQVKPYIMDLgST 272
Cdd:cd22685   6 LRIGLSASRSEPRDLYTFRPDLCEYrIGRNPEVCDVF----LCSSQHPNLISREHAEihAERDG--NGNWKVLIEDR-ST 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15232296 273 NKTYINESPIEPQRYYELFEKDTIKFGNSSREYVLLHE 310
Cdd:cd22685  79 NGTYVNDVRLQDGQRRELSDGDTITFGHKNGRRVKQWP 116

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15232296 209 EPLCLHRQSCYLFGRERRiADIPTDHPSCSKQHAVIQYRemekekPDGMmgkqvkpYIMDLGSTNKTYINESPI 282
Cdd:cd22694   8 GELRFDPGSSVRIGRDPD-ADVRLDDPRVSRRHALLEFD------GDGW-------VYTDLGSRNGTYLNGRRV 67