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Conserved domains on  [gi|42565106|ref|NP_188849|]
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Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13605777)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and NPH3 domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
188-409 3.69e-61

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


:

Pssm-ID: 460777  Cd Length: 218  Bit Score: 199.64  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   188 WWFDEVLVLSsglVEMFLKLMVL---RKFDNLIISRFLFYY-------------QKVKFCSASSHEKRKILETIIDTLcV 251
Cdd:pfam03000   2 WWFEDLSELS---IDLFKRVISAmksKGMKPEVIGEALMHYakkwlpglsrsssSSASRSEDDNSKQRELLETIVSLL-P 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   252 LDRSCVPCKSLFAVLRLALGLNINKSCMNKLEVMIGHQLDQATLDNLLVPSPSKSSHLYYVNLvlrftkafldgarsglq 331
Cdd:pfam03000  78 SEKGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETLYDVDL----------------- 140
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565106   332 lkKVSSLIDQYIAEVAPDPCLKPSKFLSLITLVPDSARESHEDIYRAIDMYLEAHTGTTDGEKLNLIRTLSYEKLSGE 409
Cdd:pfam03000 141 --KVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQKLSLE 216
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
6-93 8.40e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18312:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 105  Bit Score: 73.13  E-value: 8.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   6 SDLEVDINgEQTIFLNKQIICAYSGTLRKLLGKSTSSSGNlKVIFNDFPGGAESFEFVSRFCYNdGRVAVMPSNVVFLHC 85
Cdd:cd18312  10 SDITVRVG-NTTFHLHKFPLCSKSGYFKRLASSSSESDPS-EIELNDFPGGAEAFELVAKFCYG-MPINLTATNVVGLRC 86

                ....*...
gi 42565106  86 AAKFMEVT 93
Cdd:cd18312  87 AAEYLEMT 94
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
188-409 3.69e-61

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 199.64  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   188 WWFDEVLVLSsglVEMFLKLMVL---RKFDNLIISRFLFYY-------------QKVKFCSASSHEKRKILETIIDTLcV 251
Cdd:pfam03000   2 WWFEDLSELS---IDLFKRVISAmksKGMKPEVIGEALMHYakkwlpglsrsssSSASRSEDDNSKQRELLETIVSLL-P 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   252 LDRSCVPCKSLFAVLRLALGLNINKSCMNKLEVMIGHQLDQATLDNLLVPSPSKSSHLYYVNLvlrftkafldgarsglq 331
Cdd:pfam03000  78 SEKGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETLYDVDL----------------- 140
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565106   332 lkKVSSLIDQYIAEVAPDPCLKPSKFLSLITLVPDSARESHEDIYRAIDMYLEAHTGTTDGEKLNLIRTLSYEKLSGE 409
Cdd:pfam03000 141 --KVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQKLSLE 216
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
6-93 8.40e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 73.13  E-value: 8.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   6 SDLEVDINgEQTIFLNKQIICAYSGTLRKLLGKSTSSSGNlKVIFNDFPGGAESFEFVSRFCYNdGRVAVMPSNVVFLHC 85
Cdd:cd18312  10 SDITVRVG-NTTFHLHKFPLCSKSGYFKRLASSSSESDPS-EIELNDFPGGAEAFELVAKFCYG-MPINLTATNVVGLRC 86

                ....*...
gi 42565106  86 AAKFMEVT 93
Cdd:cd18312  87 AAEYLEMT 94
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
14-105 7.97e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 44.60  E-value: 7.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106     14 GEQTIFLNKQIICAYSGTLRKLLGKSTSSSGNLKVIFNDFPggAESFEFVSRFCYnDGRVAVMPSNVVFLHCAAKFMEVT 93
Cdd:smart00225   7 GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVS--PEDFRALLNFLY-TGKLDLPEENVEELLELADYLQIP 83
                           90
                   ....*....|..
gi 42565106     94 KVLEQTEKCMEE 105
Cdd:smart00225  84 GLVELCEEFLLK 95
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
188-409 3.69e-61

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 199.64  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   188 WWFDEVLVLSsglVEMFLKLMVL---RKFDNLIISRFLFYY-------------QKVKFCSASSHEKRKILETIIDTLcV 251
Cdd:pfam03000   2 WWFEDLSELS---IDLFKRVISAmksKGMKPEVIGEALMHYakkwlpglsrsssSSASRSEDDNSKQRELLETIVSLL-P 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   252 LDRSCVPCKSLFAVLRLALGLNINKSCMNKLEVMIGHQLDQATLDNLLVPSPSKSSHLYYVNLvlrftkafldgarsglq 331
Cdd:pfam03000  78 SEKGSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEETLYDVDL----------------- 140
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565106   332 lkKVSSLIDQYIAEVAPDPCLKPSKFLSLITLVPDSARESHEDIYRAIDMYLEAHTGTTDGEKLNLIRTLSYEKLSGE 409
Cdd:pfam03000 141 --KVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLCRLMDCQKLSLE 216
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
6-93 8.40e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 73.13  E-value: 8.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106   6 SDLEVDINgEQTIFLNKQIICAYSGTLRKLLGKSTSSSGNlKVIFNDFPGGAESFEFVSRFCYNdGRVAVMPSNVVFLHC 85
Cdd:cd18312  10 SDITVRVG-NTTFHLHKFPLCSKSGYFKRLASSSSESDPS-EIELNDFPGGAEAFELVAKFCYG-MPINLTATNVVGLRC 86

                ....*...
gi 42565106  86 AAKFMEVT 93
Cdd:cd18312  87 AAEYLEMT 94
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
14-105 7.97e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 44.60  E-value: 7.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565106     14 GEQTIFLNKQIICAYSGTLRKLLGKSTSSSGNLKVIFNDFPggAESFEFVSRFCYnDGRVAVMPSNVVFLHCAAKFMEVT 93
Cdd:smart00225   7 GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVS--PEDFRALLNFLY-TGKLDLPEENVEELLELADYLQIP 83
                           90
                   ....*....|..
gi 42565106     94 KVLEQTEKCMEE 105
Cdd:smart00225  84 GLVELCEEFLLK 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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