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Conserved domains on  [gi|15228933|ref|NP_188941|]
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receptor like protein 36 [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 18-538 1.79e-59

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 213.94  E-value: 1.79e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   18 NLTKLSELYLFGNQFTGGDT-VLANLTSLSIIDLSLNYFKSSISADLSGLHNLERF-SVYNNSFSGPFPLSllMIPSLVH 95
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISsAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYlNLSNNNFTGSIPRG--SIPNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   96 IDLSQNHFEGPIdFRNTFSLSRLRVLYVGFNNLDGLIPESISKLVNLEYLDVSHNNFGGQVPRSISKVVNLTSVDLSYNK 175
Cdd:PLN00113 145 LDLSNNMLSGEI-PNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNN 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  176 LEGQVPDFVWRSSKLDYVDLSYNSF---------------------NCFAKSV--EVIDGASLTMLNLGSNSVDGPFPKW 232
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLtgpipsslgnlknlqylflyqNKLSGPIppSIFSLQKLISLDLSDNSLSGEIPEL 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  233 ICKVKDLYALDLSNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIE 312
Cdd:PLN00113 304 VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLF 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  313 FLNVKGNKIMDTFPFWLGSLPYLKVLMLGSNAFYGPVynPSAYLGFPSIRIIDISNNNFVGSLPqdyfanwlemSLVWsg 392
Cdd:PLN00113 384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGEL--PSEFTKLPLVYFLDISNNNLQGRIN----------SRKW-- 449

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  393 sDIPQFKYMGNVNFStydsidlvYKGVETDFDRIfEGFNAIDFSGNRFSGHIPGSIGLLSELRLLNLSGNAFTGNIPPSL 472
Cdd:PLN00113 450 -DMPSLQMLSLARNK--------FFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDEL 519

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  473 ANITNLESLDLSRNNLSGEIPIS------------------------LGKLSFLSNTNFSYNHLEGLIPQSTQFATQNCS 528
Cdd:PLN00113 520 SSCKKLVSLDLSHNQLSGQIPASfsempvlsqldlsqnqlsgeipknLGNVESLVQVNISHNHLHGSLPSTGAFLAINAS 599

                        570
                 ....*....|
gi 15228933  529 SFLGNLGLYG 538
Cdd:PLN00113 600 AVAGNIDLCG 609
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 18-538 1.79e-59

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 213.94  E-value: 1.79e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   18 NLTKLSELYLFGNQFTGGDT-VLANLTSLSIIDLSLNYFKSSISADLSGLHNLERF-SVYNNSFSGPFPLSllMIPSLVH 95
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISsAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYlNLSNNNFTGSIPRG--SIPNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   96 IDLSQNHFEGPIdFRNTFSLSRLRVLYVGFNNLDGLIPESISKLVNLEYLDVSHNNFGGQVPRSISKVVNLTSVDLSYNK 175
Cdd:PLN00113 145 LDLSNNMLSGEI-PNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNN 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  176 LEGQVPDFVWRSSKLDYVDLSYNSF---------------------NCFAKSV--EVIDGASLTMLNLGSNSVDGPFPKW 232
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLtgpipsslgnlknlqylflyqNKLSGPIppSIFSLQKLISLDLSDNSLSGEIPEL 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  233 ICKVKDLYALDLSNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIE 312
Cdd:PLN00113 304 VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLF 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  313 FLNVKGNKIMDTFPFWLGSLPYLKVLMLGSNAFYGPVynPSAYLGFPSIRIIDISNNNFVGSLPqdyfanwlemSLVWsg 392
Cdd:PLN00113 384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGEL--PSEFTKLPLVYFLDISNNNLQGRIN----------SRKW-- 449

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  393 sDIPQFKYMGNVNFStydsidlvYKGVETDFDRIfEGFNAIDFSGNRFSGHIPGSIGLLSELRLLNLSGNAFTGNIPPSL 472
Cdd:PLN00113 450 -DMPSLQMLSLARNK--------FFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDEL 519

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  473 ANITNLESLDLSRNNLSGEIPIS------------------------LGKLSFLSNTNFSYNHLEGLIPQSTQFATQNCS 528
Cdd:PLN00113 520 SSCKKLVSLDLSHNQLSGQIPASfsempvlsqldlsqnqlsgeipknLGNVESLVQVNISHNHLHGSLPSTGAFLAINAS 599

                        570
                 ....*....|
gi 15228933  529 SFLGNLGLYG 538
Cdd:PLN00113 600 AVAGNIDLCG 609
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-314 2.98e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   7 DLKGNIPtsFANLTKLSELYLFGNQFTGGDTVLANLTSLSIIDLSLNYFkSSISADLSGLHNLERFSVYNNSFSGpFPLS 86
Cdd:COG4886 102 DLSGNEE--LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQL-TDLPEPLGNLTNLKSLDLSNNQLTD-LPEE 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  87 LLMIPSLVHIDLSQNHFEgpiDFRNTFS-LSRLRVLYVGFNNLDGLiPESISKLVNLEYLDVSHNNFgGQVPrSISKVVN 165
Cdd:COG4886 178 LGNLTNLKELDLSNNQIT---DLPEPLGnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL-TDLP-ELGNLTN 251

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 166 LTSVDLSYNKLEGqVPDFVwRSSKLDYVDLSYNSFNCFA-KSVEVIDGASLTMLNLGSNSVDGPFPKWICKVKDLYALDL 244
Cdd:COG4886 252 LEELDLSNNQLTD-LPPLA-NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 245 SNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIEFL 314
Cdd:COG4886 330 LKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR_8 pfam13855
Leucine rich repeat;
116-176 2.94e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.94e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15228933   116 SRLRVLYVGFNNLDGLIPESISKLVNLEYLDVSHNNFGGQVPRSISKVVNLTSVDLSYNKL 176
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 3-174 3.28e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 3.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   3 LWDNDLKgNIPtSFANLTKLSELYLFGNQFT--GGdtvLANLTSLSIIDLSLNyfksSISAdLSGLHNLerfsvynnsfs 80
Cdd:cd21340  31 LYDNKIT-KIE-NLEFLTNLTHLYLQNNQIEkiEN---LENLVNLKKLYLGGN----RISV-VEGLENL----------- 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  81 gpfplsllmiPSLVHIDLS-QNHFEG-PIDF--RNTFSLSR-LRVLYVGFNNLDGLipESISKLVNLEYLDVSHNNFG-- 153
Cdd:cd21340  90 ----------TNLEELHIEnQRLPPGeKLTFdpRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISdl 157

                       170       180
                ....*....|....*....|.
gi 15228933 154 GQVPRSISKVVNLTSVDLSYN 174
Cdd:cd21340 158 EELLDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 18-538 1.79e-59

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 213.94  E-value: 1.79e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   18 NLTKLSELYLFGNQFTGGDT-VLANLTSLSIIDLSLNYFKSSISADLSGLHNLERF-SVYNNSFSGPFPLSllMIPSLVH 95
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISsAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYlNLSNNNFTGSIPRG--SIPNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   96 IDLSQNHFEGPIdFRNTFSLSRLRVLYVGFNNLDGLIPESISKLVNLEYLDVSHNNFGGQVPRSISKVVNLTSVDLSYNK 175
Cdd:PLN00113 145 LDLSNNMLSGEI-PNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNN 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  176 LEGQVPDFVWRSSKLDYVDLSYNSF---------------------NCFAKSV--EVIDGASLTMLNLGSNSVDGPFPKW 232
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYNNLtgpipsslgnlknlqylflyqNKLSGPIppSIFSLQKLISLDLSDNSLSGEIPEL 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  233 ICKVKDLYALDLSNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIE 312
Cdd:PLN00113 304 VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLF 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  313 FLNVKGNKIMDTFPFWLGSLPYLKVLMLGSNAFYGPVynPSAYLGFPSIRIIDISNNNFVGSLPqdyfanwlemSLVWsg 392
Cdd:PLN00113 384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGEL--PSEFTKLPLVYFLDISNNNLQGRIN----------SRKW-- 449

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  393 sDIPQFKYMGNVNFStydsidlvYKGVETDFDRIfEGFNAIDFSGNRFSGHIPGSIGLLSELRLLNLSGNAFTGNIPPSL 472
Cdd:PLN00113 450 -DMPSLQMLSLARNK--------FFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDEL 519

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  473 ANITNLESLDLSRNNLSGEIPIS------------------------LGKLSFLSNTNFSYNHLEGLIPQSTQFATQNCS 528
Cdd:PLN00113 520 SSCKKLVSLDLSHNQLSGQIPASfsempvlsqldlsqnqlsgeipknLGNVESLVQVNISHNHLHGSLPSTGAFLAINAS 599

                        570
                 ....*....|
gi 15228933  529 SFLGNLGLYG 538
Cdd:PLN00113 600 AVAGNIDLCG 609
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 6-356 2.87e-38

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 151.15  E-value: 2.87e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933    6 NDLKGNIPTSFANLTKLSELYLFGNQFTGG-------------------------DTVLANLTSLSIIDLSLNYFKSSIS 60
Cdd:PLN00113 174 NVLVGKIPNSLTNLTSLEFLTLASNQLVGQiprelgqmkslkwiylgynnlsgeiPYEIGGLTSLNHLDLVYNNLTGPIP 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   61 ADLSGLHNLERFSVYNNSFSGPFPLSLLMIPSLVHIDLSQNHFEGPID--------------FRNTF---------SLSR 117
Cdd:PLN00113 254 SSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPelviqlqnleilhlFSNNFtgkipvaltSLPR 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  118 LRVLYVGFNNLDGLIPESISKLVNLEYLDVSHNNFGGQVPRSISKVVNLTSVDLSYNKLEGQVPDFVWRSSKLDYVDLSY 197
Cdd:PLN00113 334 LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQD 413

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  198 NSFNC-----FAK------------------SVEVIDGASLTMLNLGSNSVDGPFPKWIcKVKDLYALDLSNNHFNGSIP 254
Cdd:PLN00113 414 NSFSGelpseFTKlplvyfldisnnnlqgriNSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVP 492

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  255 QCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIEFLNVKGNKIMDTFPFWLGSLPY 334
Cdd:PLN00113 493 RKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVES 572

                        410       420
                 ....*....|....*....|..
gi 15228933  335 LKVLMLGSNAFYGPVYNPSAYL 356
Cdd:PLN00113 573 LVQVNISHNHLHGSLPSTGAFL 594
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 125-534 1.90e-31

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 130.35  E-value: 1.90e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  125 FNNLDGLIPESISKLVNLeylDVSHNNFGGQVPRSISKVVNLTSVDLSYNKLEGQVPDFVWRSSkldyvdlsynsfncfa 204
Cdd:PLN00113  57 VCLWQGITCNNSSRVVSI---DLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTS---------------- 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  205 ksvevidgASLTMLNLGSNSVDGPFPKWicKVKDLYALDLSNNHFNGSIPQCLkystyfhtlnlrnnslsGVLpnlfikd 284
Cdd:PLN00113 118 --------SSLRYLNLSNNNFTGSIPRG--SIPNLETLDLSNNMLSGEIPNDI-----------------GSF------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  285 SQLRSLDVSSNNLVGKLPKSLINCERIEFLNVKGNKIMDTFPFWLGSLPYLKVLMLGSNAFYGPVynPSAYLGFPSIRII 364
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI--PYEIGGLTSLNHL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  365 DISNNNFVGSLPQDyFANWLEMSLVWsgsdIPQFKYMGNVNFSTYDSIDLVykgvetdfdrifegfnAIDFSGNRFSGHI 444
Cdd:PLN00113 242 DLVYNNLTGPIPSS-LGNLKNLQYLF----LYQNKLSGPIPPSIFSLQKLI----------------SLDLSDNSLSGEI 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  445 PGSIGLLSELRLLNLSGNAFTGNIPPSLANITNLESLDLSRNNLSGEIPISLGKLSFLSNTNFSYNHLEGLIPQSTqfat 524
Cdd:PLN00113 301 PELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGL---- 376

                        410
                 ....*....|
gi 15228933  525 qnCSSflGNL 534
Cdd:PLN00113 377 --CSS--GNL 382
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-314 2.98e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   7 DLKGNIPtsFANLTKLSELYLFGNQFTGGDTVLANLTSLSIIDLSLNYFkSSISADLSGLHNLERFSVYNNSFSGpFPLS 86
Cdd:COG4886 102 DLSGNEE--LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQL-TDLPEPLGNLTNLKSLDLSNNQLTD-LPEE 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  87 LLMIPSLVHIDLSQNHFEgpiDFRNTFS-LSRLRVLYVGFNNLDGLiPESISKLVNLEYLDVSHNNFgGQVPrSISKVVN 165
Cdd:COG4886 178 LGNLTNLKELDLSNNQIT---DLPEPLGnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL-TDLP-ELGNLTN 251

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 166 LTSVDLSYNKLEGqVPDFVwRSSKLDYVDLSYNSFNCFA-KSVEVIDGASLTMLNLGSNSVDGPFPKWICKVKDLYALDL 244
Cdd:COG4886 252 LEELDLSNNQLTD-LPPLA-NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 245 SNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIEFL 314
Cdd:COG4886 330 LKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-201 6.97e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 97.23  E-value: 6.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933    1 MRLWDNDLKGNIPTSFANLTKLSELYLFGNQFTGG-DTVLANLTSLSIIDLSLNYFKSSISaDLSGLHNLERFSVYNNSF 79
Cdd:PLN00113 409 VRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRiNSRKWDMPSLQMLSLARNKFFGGLP-DSFGSKRLENLDLSRNQF 487

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   80 SGPFPLSLLMIPSLVHIDLSQNhfegpidfrntfslsrlrvlyvgfnNLDGLIPESISKLVNLEYLDVSHNNFGGQVPRS 159
Cdd:PLN00113 488 SGAVPRKLGSLSELMQLKLSEN-------------------------KLSGEIPDELSSCKKLVSLDLSHNQLSGQIPAS 542

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 15228933  160 ISKVVNLTSVDLSYNKLEGQVPDFVWRSSKLDYVDLSYNSFN 201
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-178 1.38e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 1.38e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   3 LWDNDLKgNIPTSFANLTKLSELYLFGNQFTGGDTVLANLTSLSIIDLSLNYFkSSISADLSGLHNLERFSVYNNSFSgP 82
Cdd:COG4886 120 LSGNQLT-DLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQL-TDLPEELGNLTNLKELDLSNNQIT-D 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  83 FPLSLLMIPSLVHIDLSQNHFEG-PIDFRNtfsLSRLRVLYVGFNNLDGLipESISKLVNLEYLDVSHNNFGGqVPrSIS 161
Cdd:COG4886 197 LPEPLGNLTNLEELDLSGNQLTDlPEPLAN---LTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD-LP-PLA 269

                       170
                ....*....|....*..
gi 15228933 162 KVVNLTSVDLSYNKLEG 178
Cdd:COG4886 270 NLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-371 2.32e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 2.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  45 LSIIDLSLNYFKSSISADLSGLHNLERFSVYNNSFSGPFPLSLLMIPSLVHIDLSQNHFEGPIDFRNTFSLSRLRVLYVG 124
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 125 FNNLDGLIPESISKLVNLEYLDVSHNNfggqvprSISKVVNLTSVDLSYNKLEgQVPDFVWRSSKLDYVDLSYNSFNCFA 204
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTDLP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 205 KSVEVIDgaSLTMLNLGSNSVDGpFPKWICKVKDLYALDLSNNHFNgsipqclkystyfhtlnlrnnSLSGVLPNLfikd 284
Cdd:COG4886 153 EPLGNLT--NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQIT---------------------DLPEPLGNL---- 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 285 SQLRSLDVSSNNLvGKLPKSLINCERIEFLNVKGNKImDTFPfWLGSLPYLKVLMLGSNafygPVYNPSAYLGFPSIRII 364
Cdd:COG4886 205 TNLEELDLSGNQL-TDLPEPLANLTNLETLDLSNNQL-TDLP-ELGNLTNLEELDLSNN----QLTDLPPLANLTNLKTL 277


                ....*..
gi 15228933 365 DISNNNF 371
Cdd:COG4886 278 DLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-307 6.01e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 6.01e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   3 LWDNDLKGNIPTSFANLTKLSELYLFGNQFTGGDTVLANLTSLSIIDLSLNyfkssisADLSGLHNLERFSVYNNSFSGp 82
Cdd:COG4886  56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD- 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  83 FPLSLLMIPSLVHIDLSQNHFEgpiDFRNTFS-LSRLRVLYVGFNNLDGlIPESISKLVNLEYLDVSHNNFgGQVPRSIS 161
Cdd:COG4886 128 LPEELANLTNLKELDLSNNQLT---DLPEPLGnLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQI-TDLPEPLG 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 162 KVVNLTSVDLSYNKLEgQVPDFVWRSSKLDYVDLSYNSFncfaKSVEVIDG-ASLTMLNLGSNSVDGpFPKwICKVKDLY 240
Cdd:COG4886 203 NLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQL----TDLPELGNlTNLEELDLSNNQLTD-LPP-LANLTNLK 275

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15228933 241 ALDLSNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLIN 307
Cdd:COG4886 276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
PLN03150 PLN03150
hypothetical protein; Provisional
 416-551 1.41e-13

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 73.70  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  416 YKGVETDFDRIFEGF--NAIDFSGNRFSGHIPGSIGLLSELRLLNLSGNAFTGNIPPSLANITNLESLDLSRNNLSGEIP 493
Cdd:PLN03150 404 WSGADCQFDSTKGKWfiDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP 483

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15228933  494 ISLGKLSFLSNTNFSYNHLEGLIPQST-----QFATQNCSSFLGNLGLYGFREiCGEshHVPV 551
Cdd:PLN03150 484 ESLGQLTSLRILNLNGNSLSGRVPAALggrllHRASFNFTDNAGLCGIPGLRA-CGP--HLSV 543
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
165-517 2.32e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 2.32e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 165 NLTSVDLSYNKLEGQVPDFVWRSSKLDYVDLSYNSFNCFAKSVEVIDGASLTMLNLGSNsvdgpfpKWICKVKDLYALDL 244
Cdd:COG4886  48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 245 SNNHFNgSIPQCLKYSTYFHTLNLRNNSLSgVLPNLFIKDSQLRSLDVSSNNLVGkLPKSLINCERIEFLNVKGNKImDT 324
Cdd:COG4886 121 SGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQI-TD 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 325 FPFWLGSLPYLKVLMLGSNAFYgpvYNPSAYLGFPSIRIIDISNNNFvgslpqdyfanwlemslvwsgSDIPQFKYMGNV 404
Cdd:COG4886 197 LPEPLGNLTNLEELDLSGNQLT---DLPEPLANLTNLETLDLSNNQL---------------------TDLPELGNLTNL 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 405 NFstydsidlvykgvetdfdrifegfnaIDFSGNRFSGhipgsigllselrllnlsgnaftgniPPSLANITNLESLDLS 484
Cdd:COG4886 253 EE--------------------------LDLSNNQLTD--------------------------LPPLANLTNLKTLDLS 280

                       330       340       350
                ....*....|....*....|....*....|...
gi 15228933 485 RNNLSGEIPISLGKLSFLSNTNFSYNHLEGLIP 517
Cdd:COG4886 281 NNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
PLN03150 PLN03150
hypothetical protein; Provisional
 123-199 4.75e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.06  E-value: 4.75e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15228933  123 VGFNN--LDGLIPESISKLVNLEYLDVSHNNFGGQVPRSISKVVNLTSVDLSYNKLEGQVPDFVWRSSKLDYVDLSYNS 199
Cdd:PLN03150 423 LGLDNqgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501
PLN03150 PLN03150
hypothetical protein; Provisional
 215-278 9.50e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.29  E-value: 9.50e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15228933  215 LTMLNLGSNSVDGPFPKWICKVKDLYALDLSNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLP 278
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVP 507
PLN03150 PLN03150
hypothetical protein; Provisional
 209-305 3.24e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 56.36  E-value: 3.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  209 VIDGasltmLNLGSNSVDGPFPKWICKVKDLYALDLSNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLR 288
Cdd:PLN03150 419 FIDG-----LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLR 493

                         90
                 ....*....|....*..
gi 15228933  289 SLDVSSNNLVGKLPKSL 305
Cdd:PLN03150 494 ILNLNGNSLSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 32-160 1.21e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.82  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   32 FTGGDTVLANLTSLSIID-LSLNY--FKSSISADLSGLHNLERFSVYNNSFSGPFPLSLLMIPSLVHIDLSQNHFegpid 108
Cdd:PLN03150 404 WSGADCQFDSTKGKWFIDgLGLDNqgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF----- 478

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 15228933  109 frntfslsrlrvlyvgfnnlDGLIPESISKLVNLEYLDVSHNNFGGQVPRSI 160
Cdd:PLN03150 479 --------------------NGSIPESLGQLTSLRILNLNGNSLSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 5-87 1.94e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.05  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933    5 DND-LKGNIPTSFANLTKLSELYLFGNQFTGGDTV-LANLTSLSIIDLSLNYFKSSISADLSGLHNLERFSVYNNSFSGP 82
Cdd:PLN03150 426 DNQgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPsLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGR 505


                 ....*
gi 15228933   83 FPLSL 87
Cdd:PLN03150 506 VPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 115-181 2.06e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.05  E-value: 2.06e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15228933  115 LSRLRVLYVGFNNLDGLIPESISKLVNLEYLDVSHNNFGGQVPRSISKVVNLTSVDLSYNKLEGQVP 181
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVP 507
LRR_8 pfam13855
Leucine rich repeat;
116-176 2.94e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.94e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15228933   116 SRLRVLYVGFNNLDGLIPESISKLVNLEYLDVSHNNFGGQVPRSISKVVNLTSVDLSYNKL 176
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 3-174 3.28e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 3.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933   3 LWDNDLKgNIPtSFANLTKLSELYLFGNQFT--GGdtvLANLTSLSIIDLSLNyfksSISAdLSGLHNLerfsvynnsfs 80
Cdd:cd21340  31 LYDNKIT-KIE-NLEFLTNLTHLYLQNNQIEkiEN---LENLVNLKKLYLGGN----RISV-VEGLENL----------- 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  81 gpfplsllmiPSLVHIDLS-QNHFEG-PIDF--RNTFSLSR-LRVLYVGFNNLDGLipESISKLVNLEYLDVSHNNFG-- 153
Cdd:cd21340  90 ----------TNLEELHIEnQRLPPGeKLTFdpRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISdl 157

                       170       180
                ....*....|....*....|.
gi 15228933 154 GQVPRSISKVVNLTSVDLSYN 174
Cdd:cd21340 158 EELLDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
160-515 3.45e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 3.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 160 ISKVVNLTSVDLSYNKLEGQVPDFVWRSSKLDYVDLSYNSFNCFAKSVEVIDGASLTMLNLGSNSVDGPFPKWICKVKDL 239
Cdd:COG4886  19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 240 YALDLSNNhfngsipQCLKYSTYFHTLNLRNNSLSgVLPNLFIKDSQLRSLDVSSNNLvGKLPKSLINCERIEFLNVKGN 319
Cdd:COG4886  99 TELDLSGN-------EELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQL-TDLPEPLGNLTNLKSLDLSNN 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 320 KIMDtFPFWLGSLPYLKVLMLGSNafygpvynpsaylgfpsiRIIDISNNnfVGSLPQdyfanwLEMslvwsgsdipqfk 399
Cdd:COG4886 170 QLTD-LPEELGNLTNLKELDLSNN------------------QITDLPEP--LGNLTN------LEE------------- 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 400 ymgnvnfstydsidlvykgvetdfdrifegfnaIDFSGNRFSghipgsigllselrllnlsgnaftgNIPPSLANITNLE 479
Cdd:COG4886 210 ---------------------------------LDLSGNQLT-------------------------DLPEPLANLTNLE 231

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 15228933 480 SLDLSRNNLSgEIPiSLGKLSFLSNTNFSYNHLEGL 515
Cdd:COG4886 232 TLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLTDL 265
PLN03150 PLN03150
hypothetical protein; Provisional
 145-230 3.57e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 53.28  E-value: 3.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  145 LDVSHNNFGGQVPRSISKVVNLTSVDLSYNKLEGQVPDFVWRSSKLDYVDLSYNSFNcfaKSVEVIDG--ASLTMLNLGS 222
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---GSIPESLGqlTSLRILNLNG 499


                 ....*...
gi 15228933  223 NSVDGPFP 230
Cdd:PLN03150 500 NSLSGRVP 507
PLN03150 PLN03150
hypothetical protein; Provisional
 241-333 3.70e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 53.28  E-value: 3.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  241 ALDLSNNHFNGSIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIEFLNVKGNK 320
Cdd:PLN03150 422 GLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501

                         90
                 ....*....|...
gi 15228933  321 IMDTFPFWLGSLP 333
Cdd:PLN03150 502 LSGRVPAALGGRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 266-359 5.40e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 5.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  266 LNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIEFLNVKGNKIMDTFPFWLGSLPYLKVLMLGSNAF 345
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502

                         90
                 ....*....|....
gi 15228933  346 YGPVynPSAYLGFP 359
Cdd:PLN03150 503 SGRV--PAALGGRL 514
LRR_8 pfam13855
Leucine rich repeat;
91-152 9.57e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 9.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15228933    91 PSLVHIDLSQNHFEGpIDFRNTFSLSRLRVLYVGFNNLDGLIPESISKLVNLEYLDVSHNNF 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 141-312 2.74e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 2.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 141 NLEYLDVSHNNFGGQVPRSISKVV----NLTSVDLSYNKL--EGQVpdfvwrsskldyvdlsynsfnCFAKSVEVidGAS 214
Cdd:COG5238 265 TVETLYLSGNQIGAEGAIALAKALqgntTLTSLDLSVNRIgdEGAI---------------------ALAEGLQG--NKT 321

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 215 LTMLNLGSNSVDG----PFPKWICKVKDLYALDLSNNHFNG----SIPQCLKYSTYFHTLNLRNNSLSGVLPNLFIKDSQ 286
Cdd:COG5238 322 LHTLNLAYNGIGAqgaiALAKALQENTTLHSLDLSDNQIGDegaiALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQ 401

                       170       180       190
                ....*....|....*....|....*....|.
gi 15228933 287 ---LRSLDVSSnNLVGKLPKSLIN--CERIE 312
Cdd:COG5238 402 tnrLHTLILDG-NLIGAEAQQRLEqlLERIK 431
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 209-321 8.12e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.17  E-value: 8.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 209 VIDGASLTMLNLGSNSVDGP----FPKWICKVKDLYALDLSNNHFNGS----IPQCLKYSTYFHTLNLRNNSLS--GV-- 276
Cdd:COG5238 204 LTQNTTVTTLWLKRNPIGDEgaeiLAEALKGNKSLTTLDLSNNQIGDEgviaLAEALKNNTTVETLYLSGNQIGaeGAia 283

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15228933 277 LPNLFIKDSQLRSLDVSSNNL----VGKLPKSLINCERIEFLNVKGNKI 321
Cdd:COG5238 284 LAKALQGNTTLTSLDLSVNRIgdegAIALAEGLQGNKTLHTLNLAYNGI 332
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 87-223 1.09e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  87 LLMIPSLVHIDLSQNHF--EGPIDFRNTFSL-SRLRVLYVGFNNLDGLIPESISKLV----NLEYLDVSHNNFGGQVPRS 159
Cdd:COG5238 232 LKGNKSLTTLDLSNNQIgdEGVIALAEALKNnTTVETLYLSGNQIGAEGAIALAKALqgntTLTSLDLSVNRIGDEGAIA 311

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15228933 160 ISKVV----NLTSVDLSYNKLEGQVPDF----VWRSSKLDYVDLSYNSFNcfAKSVEVIDGA-----SLTMLNLGSN 223
Cdd:COG5238 312 LAEGLqgnkTLHTLNLAYNGIGAQGAIAlakaLQENTTLHSLDLSDNQIG--DEGAIALAKYlegntTLRELNLGKN 386
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 16-201 1.11e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  16 FANLTKLSELYLFGNQFT-GGDTVLANLT---SLSIIDLSLNYF-----KSSISADLSGLHNLERFSVYNNSFSGP--FP 84
Cdd:cd00116  77 LTKGCGLQELDLSDNALGpDGCGVLESLLrssSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGAscEA 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  85 LSLLM--IPSLVHIDLSQNHFEGPiDFRNTF----SLSRLRVLYVGFNNL----DGLIPESISKLVNLEYLDVSHNNFGG 154
Cdd:cd00116 157 LAKALraNRDLKELNLANNGIGDA-GIRALAeglkANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTD 235

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15228933 155 Q-----VPRSISKVVNLTSVDLSYNKLE----GQVPDFVWRSSKLDYVDLSYNSFN 201
Cdd:cd00116 236 AgaaalASALLSPNISLLTLSLSCNDITddgaKDLAEVLAEKESLLELDLRGNKFG 291
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 44-317 1.34e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  44 SLSIIDLSLNYFKSSISADLSGLHNLE------RFSVYNNSFS----GPFPlSLLMIPSLVHIDLSQNHFE---GPIDFR 110
Cdd:cd00116  52 SLKELCLSLNETGRIPRGLQSLLQGLTkgcglqELDLSDNALGpdgcGVLE-SLLRSSSLQELKLNNNGLGdrgLRLLAK 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 111 NTFSLS-RLRVLYVGFNNLDGLIPESISKLV----NLEYLDVSHNNFGGQVPRSISKVVnltsvdLSYNKLEgqvpdfvw 185
Cdd:cd00116 131 GLKDLPpALEKLVLGRNRLEGASCEALAKALranrDLKELNLANNGIGDAGIRALAEGL------KANCNLE-------- 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 186 rssKLDYVDLSYNSFNCFAKSVEVIDGASLTMLNLGSNSVDGpfpkwickvKDLYALDLSNNHFNgsipQCLKystyfhT 265
Cdd:cd00116 197 ---VLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTD---------AGAAALASALLSPN----ISLL------T 254

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15228933 266 LNLRNN--------SLSGVLPNLfikdSQLRSLDVSSNNL----VGKLPKSLI-NCERIEFLNVK 317
Cdd:cd00116 255 LSLSCNditddgakDLAEVLAEK----ESLLELDLRGNKFgeegAQLLAESLLePGNELESLWVK 315
LRR_8 pfam13855
Leucine rich repeat;
264-321 1.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15228933   264 HTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSNNLVGKLPKSLINCERIEFLNVKGNKI 321
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 39-212 7.31e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 7.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933  39 LANLTSLSIIDLSLnyfkSSISaDLSGLHNLERFSVYNNSFSGPFPLSLLmiPSLVHIDLSQNHFEgPIDfrNTFSLSRL 118
Cdd:cd21340   1 LKRITHLYLNDKNI----TKID-NLSLCKNLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIE-KIE--NLENLVNL 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228933 119 RVLYVGFN------NLDGLI---------------------PESISKLVN-LEYLDVSHNNFggQVPRSISKVVNLTSVD 170
Cdd:cd21340  71 KKLYLGGNrisvveGLENLTnleelhienqrlppgekltfdPRSLAALSNsLRVLNISGNNI--DSLEPLAPLRNLEQLD 148

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15228933 171 LSYNKLE--GQVPDFVWRSSKLDYVDLSYNSFnC-----------FAKSVEVIDG 212
Cdd:cd21340 149 ASNNQISdlEELLDLLSSWPSLRELDLTGNPV-CkkpkyrdkiilASKSLEVLDG 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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