NCBI Conserved Domain Search

Conserved domains on [gi|42565446|ref|NP_189965|]

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zinc induced facilitator-like 2 [Arabidopsis thaliana]

Protein Classification

MFS transporter( domain architecture ID 13023689)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH: 1.20.1250.20

Gene Ontology: GO:0022857|GO:0055085|GO:0016020

PubMed: 26758938|26098515|26234418

SCOP: 3000310

TCDB: 2.A.1

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

40-471

1.30e-74

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 238.25 E-value: 1.30e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALPISSLFPYIYFMIRDFhiaKQEEDIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIF 119
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREF---NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 120 NTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPaekypnifs 199
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 200 qssvfgrFPYFLPSLVISVYATAVLIACWWLPetlhtrcriaqgrlnptelnddesrgggldeqkiinkpsllrnRPLMA 279
Cdd:cd17330 149 -------YGYALPFLVAAALALLNLVLVLFFL-------------------------------------------PPLRR 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 280 IIIVYCVFSLQEIAYNEIFSLWAVSDrsyggLSFSSQDVGEVLAISGLGLLVFQLLVYPPLEKSVGLLAVIRLSAVLLIP 359
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 360 LLSCYPYIALLSGVTLhlvincASIIKNALSISLVTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAGGGVLFSwa 439
Cdd:cd17330 254 GLLLLPFASSVPLLVL------AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS-- 325

                       410       420       430
                ....*....|....*....|....*....|..
gi 42565446 440 qkrqdatfLPGDEMVFLVLNLVQLVGLILTFI 471
Cdd:cd17330 326 --------FLGPGVPFLLAAGLLLIALFLLSL 349

Name

Accession

Description

Interval

E-value

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

40-471

1.30e-74

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 238.25 E-value: 1.30e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALPISSLFPYIYFMIRDFhiaKQEEDIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIF 119
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREF---NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 120 NTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPaekypnifs 199
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 200 qssvfgrFPYFLPSLVISVYATAVLIACWWLPetlhtrcriaqgrlnptelnddesrgggldeqkiinkpsllrnRPLMA 279
Cdd:cd17330 149 -------YGYALPFLVAAALALLNLVLVLFFL-------------------------------------------PPLRR 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 280 IIIVYCVFSLQEIAYNEIFSLWAVSDrsyggLSFSSQDVGEVLAISGLGLLVFQLLVYPPLEKSVGLLAVIRLSAVLLIP 359
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 360 LLSCYPYIALLSGVTLhlvincASIIKNALSISLVTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAGGGVLFSwa 439
Cdd:cd17330 254 GLLLLPFASSVPLLVL------AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS-- 325

                       410       420       430
                ....*....|....*....|....*....|..
gi 42565446 440 qkrqdatfLPGDEMVFLVLNLVQLVGLILTFI 471
Cdd:cd17330 326 --------FLGPGVPFLLAAGLLLIALFLLSL 349

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

37-423

1.30e-28

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.84 E-value: 1.30e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  37 LSFIWLVSLCTALPISSLFPYIYFMIRDFHIAkqeediGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSV 116
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALPLIAADLGAS------PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 117 IIFNTLFGLSTSFWLAISVRFLLGCFNCLL-GVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekyp 195
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------ 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 196 nIFSQSSVFGrfpyflpsLVISVYATAVLIACWWLPETLHTRCRIAQGRLnptelnddesrgggldeqkiinkPSLLRNR 275
Cdd:COG2814 160 -LFGWRWVFL--------VNAVLALLALLLLLRLLPESRPAARARLRGSL-----------------------RELLRRP 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 276 PLMAIIIVYCVFSLQEIAYNEIFSLWAVSdrsygGLSFSSQDVGEVLAISGLGLLVFQLLVyPPLEKSVGLLAVIRLSAV 355
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQE-----VLGLSASAAGLLLALFGLGGVLGALLA-GRLADRFGRRRLLLIGLL 281

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565446 356 LLIPLLSCYPYIALLSGVTLHLVINCASIiknalsISLVTGLFIMLNKAVPQNQRGAANGISMTAMSV 423
Cdd:COG2814 282 LLALGLLLLALAGSLWLLLLALFLLGFGF------GLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343

MFS_1

pfam07690

Major Facilitator Superfamily;

40-429

2.33e-21

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.79 E-value: 2.33e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    40 IWLVSLCTALPISSLFPYI-YFMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVII 118
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTE------IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   119 FNTLFGLSTSFWLAISVRFLLG-CFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekypnI 197
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGlGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-------L 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   198 FSQSSVFgrfpyflpslVISVYATAVLIACWWLPETLHTRcriaqgrlnptelndDESRGGGLDEQKIINKPSLLRNRPL 277
Cdd:pfam07690 148 FGWRAAF----------LILAILSLLAAVLLLLPRPPPES---------------KRPKPAEEARLSLIVAWKALLRDPV 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   278 MAIIIVYCVFSLQEIAYNEIFSLWAVSdrsyggLSFSSQDVGEVLAISGLGLLVFQLLVyPPLEKSVGLLAVIRLSAVLL 357
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEV------LGLSALLAGLLLGLGGLLGAIGRLLL-GRLSDRLGRRRRLLLALLLL 275

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42565446   358 IPLLSCYPYIALLSGVTLHLVincASIIKNALSISLVTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGP 429
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLL---ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344

2_A_01_02

TIGR00880

Multidrug resistance protein;

83-233

1.53e-13

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 67.67 E-value: 1.53e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCF-NCLLGVIRAYASEVVSEEY 161
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGaAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42565446   162 NALSLSVVSTSRGIGLILGPAIGGYLAQPAEKypnifsqssvfgRFPYFLpslvISVYATAVLIA-CWWLPET 233
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGW------------RAPFLF----LAILALAAFILlAFLLPET 141

PRK09874

multidrug efflux MFS transporter MdtG;

36-204

4.37e-10

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 61.47 E-value: 4.37e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   36 HLSFIWLVSLCTALPISSLFPYIYFMIRDFHIAKQEEdIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFS 115
Cdd:PRK09874  15 NLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSA-LNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  116 VIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAEKYP 195
Cdd:PRK09874  94 MGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRP 173


                 ....*....
gi 42565446  196 NIFSQSSVF 204
Cdd:PRK09874 174 VFFITASVL 182

Name

Accession

Description

Interval

E-value

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

40-471

1.30e-74

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 238.25 E-value: 1.30e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALPISSLFPYIYFMIRDFhiaKQEEDIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIF 119
Cdd:cd17330   1 LFLVVFLDALGFGIVFPVLPFYVREF---NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 120 NTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPaekypnifs 199
Cdd:cd17330  78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 200 qssvfgrFPYFLPSLVISVYATAVLIACWWLPetlhtrcriaqgrlnptelnddesrgggldeqkiinkpsllrnRPLMA 279
Cdd:cd17330 149 -------YGYALPFLVAAALALLNLVLVLFFL-------------------------------------------PPLRR 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 280 IIIVYCVFSLQEIAYNEIFSLWAVSDrsyggLSFSSQDVGEVLAISGLGLLVFQLLVYPPLEKSVGLLAVIRLSAVLLIP 359
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 360 LLSCYPYIALLSGVTLhlvincASIIKNALSISLVTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAGGGVLFSwa 439
Cdd:cd17330 254 GLLLLPFASSVPLLVL------AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS-- 325

                       410       420       430
                ....*....|....*....|....*....|..
gi 42565446 440 qkrqdatfLPGDEMVFLVLNLVQLVGLILTFI 471
Cdd:cd17330 326 --------FLGPGVPFLLAAGLLLIALFLLSL 349

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

40-471

7.76e-29

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.91 E-value: 7.76e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALPISSLFPYIYFMIRDFHIAkqeediGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIF 119
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGAS------VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVS 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 120 NTLFGLSTSFWLAISVRFLLGCFNCLLGVIR-AYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekypnif 198
Cdd:cd17325  75 TLLFAFATSYWQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 199 sqssVFG-RFPYFLPSLVISVyatAVLIACWWLPETLHTRCRIAQGRLNPTELNDdesrgggldeqkiinkpSLLRNRPL 277
Cdd:cd17325 146 ----ALGyRAPFLVCAALALL---ALVLALLLLPEPRPPPNKRAVSAARLRSGLR-----------------LLLRDRRL 201

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 278 MAIIIVYCVFSLQEIAYNEIFSLWAVSDrsyggLSFSSQDVGEVLAISGLGLLVFQL----LVYPPLEKSVGLLAVIRLS 353
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAEL-----GGLSPAQIGLLFGAQGLASALSQPpagkLSDRIGRKPLILIGLLLSA 276

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 354 -AVLLIPLLSCYPYIALLSGVTlhlvincasiiknALSISLV-TGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAG 431
Cdd:cd17325 277 vALLLLPLATSFWLLLLLLALL-------------GLGLGLVfPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 42565446 432 GGVLFSWAqkrqdatflpGDEMVFLVLNLVQLVGLILTFI 471
Cdd:cd17325 344 GGFLYDAF----------GFATPFLAAAALLLLAAVLFLL 373

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

37-423

1.30e-28

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.84 E-value: 1.30e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  37 LSFIWLVSLCTALPISSLFPYIYFMIRDFHIAkqeediGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSV 116
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALPLIAADLGAS------PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 117 IIFNTLFGLSTSFWLAISVRFLLGCFNCLL-GVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekyp 195
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------ 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 196 nIFSQSSVFGrfpyflpsLVISVYATAVLIACWWLPETLHTRCRIAQGRLnptelnddesrgggldeqkiinkPSLLRNR 275
Cdd:COG2814 160 -LFGWRWVFL--------VNAVLALLALLLLLRLLPESRPAARARLRGSL-----------------------RELLRRP 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 276 PLMAIIIVYCVFSLQEIAYNEIFSLWAVSdrsygGLSFSSQDVGEVLAISGLGLLVFQLLVyPPLEKSVGLLAVIRLSAV 355
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQE-----VLGLSASAAGLLLALFGLGGVLGALLA-GRLADRFGRRRLLLIGLL 281

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565446 356 LLIPLLSCYPYIALLSGVTLHLVINCASIiknalsISLVTGLFIMLNKAVPQNQRGAANGISMTAMSV 423
Cdd:COG2814 282 LLALGLLLLALAGSLWLLLLALFLLGFGF------GLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

40-470

1.30e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 96.34 E-value: 1.30e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALPISSLFPYIYFMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIF 119
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQ------LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 120 NTLFGLSTSFWLAISVRFLLGCFNCLLGVIR-AYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekypnif 198
Cdd:cd06174  75 ALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS--------- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 199 sqssvFGRFPYFLPSLVISVYATAVLIACWWLPETLHTRCRIAQGRLNPTElnddesrgggldeqKIINKPSLLRNRPLM 278
Cdd:cd06174 146 -----SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKS--------------VLKLLKRVLKNPGLW 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 279 AIIIVYcvfSLQEIAYNEIFSLWAVSDRSYGGLSFSSqdVGEVLAISGLGLLVFQLLVYPPLEKSVGLLAVIRLSAVLLI 358
Cdd:cd06174 207 LLLLAI---FLVNLAYYSFSTLLPLFLLDLGGLSVAV--AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMA 281

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 359 PLLscypyIALLSGVTLHLVINCASIIKNALSIsLVTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAGGGVLFSW 438
Cdd:cd06174 282 LGL-----ALLLLAPSLLLLLLLLLLLGFGLGG-LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355

                       410       420       430
                ....*....|....*....|....*....|..
gi 42565446 439 AqkrqdatflPGDEMVFLVLNLVQLVGLILTF 470
Cdd:cd06174 356 T---------FGLTGAFLVLAVLLLLAAILLL 378

MFS_1

pfam07690

Major Facilitator Superfamily;

40-429

2.33e-21

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 94.79 E-value: 2.33e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    40 IWLVSLCTALPISSLFPYI-YFMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVII 118
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTE------IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   119 FNTLFGLSTSFWLAISVRFLLG-CFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekypnI 197
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGlGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-------L 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   198 FSQSSVFgrfpyflpslVISVYATAVLIACWWLPETLHTRcriaqgrlnptelndDESRGGGLDEQKIINKPSLLRNRPL 277
Cdd:pfam07690 148 FGWRAAF----------LILAILSLLAAVLLLLPRPPPES---------------KRPKPAEEARLSLIVAWKALLRDPV 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   278 MAIIIVYCVFSLQEIAYNEIFSLWAVSdrsyggLSFSSQDVGEVLAISGLGLLVFQLLVyPPLEKSVGLLAVIRLSAVLL 357
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEV------LGLSALLAGLLLGLGGLLGAIGRLLL-GRLSDRLGRRRRLLLALLLL 275

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42565446   358 IPLLSCYPYIALLSGVTLHLVincASIIKNALSISLVTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGP 429
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLL---ALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

37-468

4.56e-19

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 88.82 E-value: 4.56e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  37 LSFIWLVSLCTALPISSLFPYIY-FMIRDFHIAkqeediGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFS 115
Cdd:cd17329   1 LWVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLS------ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 116 VIIFNTLFGLSTSFWLAISVRFLLGCFNCLLG-VIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaeky 194
Cdd:cd17329  75 RALGFALLGFAHSPWLFAIALVLTGFGGGLFEpASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL----- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 195 pniFSQSSVFgrfpyflpSLVISVYATAVLIACWWLPETLHTRCRIAQGRLnptelnddesrgggldeqkIINKPSLLRN 274
Cdd:cd17329 150 ---YSFRLLF--------LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEI-------------------LRGYKIVLRD 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 275 RPLMAIIIVYCVFSLQEIAYNEIFSLWAVSDrsyggLSFSSQDVGEVLAISGLGLLVFQLLVYPPLEKSvGLLAVIRLSA 354
Cdd:cd17329 200 RAFLLFLLASFLISLIYFQLESTLPVYVVEI-----LGLGESLLGLLLALNALLIVLLQFPVARLVERF-RLRKILMIGI 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 355 VLLIpllscYPYIALLSGVTLHLVINCASIIknALSISLVTGLFIML-NKAVPQNQRGAANGISMTAMSVFKSFGPAGGG 433
Cdd:cd17329 274 LLFA-----IGFAVLAFANTLAVLILAMIVL--TLGEMLVFPAVQTLvAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346

                       410       420       430
                ....*....|....*....|....*....|....*
gi 42565446 434 VLfswaqkrqdaTFLPGDEMVFLVLNLVQLVGLIL 468
Cdd:cd17329 347 LL----------LDLLGPGLPWLILAALGLIAAAL 371

MFS_TetA

cd17388

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...

37-469

8.70e-17

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 81.91 E-value: 8.70e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  37 LSFIWLVSLCTALPISSLFPYIYFMIRDFhiAKQEEDIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSV 116
Cdd:cd17388   1 LIFILVTVLLDAMGIGLIMPVLPTLLREF--VGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 117 IIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAEKYPn 196
Cdd:cd17388  79 ALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAP- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 197 ifsqssvfgrfpyFLPSLVISvyATAVLIACWWLPETLHTRCRIA--QGRLNPtelnddesrgggldeqkiINKPSLLRN 274
Cdd:cd17388 158 -------------FLVAAGLN--GLNFLLGLFVLPESLPPERRRAfrWRRANP------------------FGSLRWLTG 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 275 RPLMAIIIVycVFSLQEIAYNEIFSLWAVsdrsYGGLSF--SSQDVGEVLAISGLGLLVFQLLVYPPLEKSVGLLAVIRL 352
Cdd:cd17388 205 FPGLLGLLA--VFFLIQLIGQVPATTWVL----FTEDRFdwSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILL 278

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 353 SAVlliplLSCYPYIaLLSGVTLHLVINCASIIKNALSISLvTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAGG 432
Cdd:cd17388 279 GLA-----ADALGFL-LLAFATQGWMVFPILILLALGGIAG-PALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLF 351

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 42565446 433 GVLFSWAqkrqdATFLPGdeMVFLVLNLVQLVGLILT 469
Cdd:cd17388 352 TGIFAAS-----PATWPG--LAWIIGAALYLICLVLA 381

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

26-189

1.57e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 77.99 E-value: 1.57e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  26 KQQQRGVPYLHLSFIWLVSLCTALPISSLFPYIYFMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGR 105
Cdd:COG2271   1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ------LGLLASAFFLGYALGQIPAGLLADRFGR 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 106 KPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFN-CLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIG 184
Cdd:COG2271  75 RRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEaGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154


                ....*
gi 42565446 185 GYLAQ 189
Cdd:COG2271 155 GWLLA 159

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

40-471

2.00e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 77.61 E-value: 2.00e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALP---ISSLFPYIYFMIRDFHIAKqeedigFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSV 116
Cdd:cd17474   1 LYAVFFATLLAvlgVSIVDPILPAIAEALGASP------AQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLF 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 117 IIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIR-AYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAqpaekyp 195
Cdd:cd17474  75 GIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLAlTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA------- 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 196 nifsqsSVFGRFPYFLPSLVISVyatAVLIACWWLPETLHTrcriaqgrlnptelnDDESRGGGLDEQKIINKPSLLRNR 275
Cdd:cd17474 148 ------AISWRYPFFLLAALIPV---AFLAILFLLPEPKEK---------------AKSSSATKLRDLKKALRGRGLLTF 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 276 PLMAIIIVYCVFSLqeiayneIFSLWAVSDRSYGglsFSSQDVGEVLAISGLGLLVFQLLVYPPLEKSVGLLAVIRLSAV 355
Cdd:cd17474 204 LVSAFLYFFLYFAF-------LTYLPFLLELLYG---ISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLL 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 356 LLIPLLscypyIALLSGVTLHLVINCASIIKNALSISLVTgLFIMLNKAVPQNQRGAAngisMTAMSVFKSFGPAGGGVL 435
Cdd:cd17474 274 LYALSL-----LLLGFVPSLALLLIAIVLFGLGLGLNLPL-LTTLVTELAPEEERGTA----SSLYNFVRFLGQAVGPLL 343

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 42565446 436 FSWAQKRQdatflpGDEMVFLVLNLVQLVGLILTFI 471
Cdd:cd17474 344 FGLLLEIF------GLSAPFLVGAAIALAAAVLLAL 373

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

76-189

5.20e-14

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 72.54 E-value: 5.20e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  76 FYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLL-GVIRAYAS 154
Cdd:COG0477  49 AQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLmPGALALIA 128

                        90       100       110
                ....*....|....*....|....*....|....*
gi 42565446 155 EVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:COG0477 129 ELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

41-189

1.20e-13

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 72.30 E-value: 1.20e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  41 WLVSLCTALPISSLFPYIYFMIRDFHIAKQEEdIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFN 120
Cdd:cd17391   2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGL-VELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42565446 121 TLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17391  81 GLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLAD 149

2_A_01_02

TIGR00880

Multidrug resistance protein;

83-233

1.53e-13

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 67.67 E-value: 1.53e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCF-NCLLGVIRAYASEVVSEEY 161
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGaAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42565446   162 NALSLSVVSTSRGIGLILGPAIGGYLAQPAEKypnifsqssvfgRFPYFLpslvISVYATAVLIA-CWWLPET 233
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGW------------RAPFLF----LAILALAAFILlAFLLPET 141

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

78-470

2.69e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.04 E-value: 2.69e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLL-GVIRAYASEV 156
Cdd:cd17324  36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 157 VSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekypnIFSQSSVFgrfpyflpsLVISVYATAVLIACW-WLPETLH 235
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-------LLGWRAAF---------LAIAVLALLAALLLWrLLPSLPP 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 236 TrcriaqgrlNPTELNDdesrgggldeqkIINKPSLLRNRPLM-AIIIVYCVFSLQEIAYNEIFSLwaVSDRSYgglsFS 314
Cdd:cd17324 180 K---------KPGSLGL------------LSSLLLLLRNPRLRlAYLITFLLFGGFFALYTYLAPF--LTDVPG----FS 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 315 SQDVGEVLAISGLGLLVFQLLVYPPLEKSVGLlavirlsAVLLIPLLSCYPYIALLSGVTLHLVINCASIIKNALSISLV 394
Cdd:cd17324 233 SSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR-------ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH 305

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565446 395 TGLFIMLNKAVPQNqRGAANGISMTAMSVFKSFGPAGGGVLFSWAqkrqdatflpGDEMVFLVLNLVQLVGLILTF 470
Cdd:cd17324 306 SALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHG----------GWAGVGWVGAALLLLALLLAL 370

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

83-235

1.52e-12

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 68.76 E-value: 1.52e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVI-RAYASEVVSEEY 161
Cdd:cd17320  41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAE 120

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42565446 162 NALSLSVVSTSRGIGLILGPAIGGYLAQpaekypnIFSQSSVFgrfpyflpsLVISVYATAVLIACWW-LPETLH 235
Cdd:cd17320 121 LAKIFSLLMMILAIAPALAPLLGGLLLL-------FFGWRAIF---------VFLALLGLLLLLLVLLfLPETLP 179

MFS_MFSD9

cd17390

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...

76-189

1.74e-12

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 68.41 E-value: 1.74e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  76 FYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASE 155
Cdd:cd17390  31 TVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSD 110

                        90       100       110
                ....*....|....*....|....*....|....
gi 42565446 156 VVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17390 111 LVSEQERSRVLGRFNAASSLGFILGPVVGGHLAE 144

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

35-363

2.56e-12

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 2.56e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  35 LHLSFIWLVSLCTALPISSLFPYIYFMIRDFHIAKqeedigFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTF 114
Cdd:COG0738   8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSD------AQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 115 SVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGV-IRAYASEVVSEEYNALsLSVVSTSRGIGLILGPAIGGYLaqpaek 193
Cdd:COG0738  82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVaANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLL------ 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 194 ypnIFSQSSVFGRFPYFLPSLVISVyaTAVLIACWWLPEtlhtrcriaqgrlnpTELNDDESRGGGldeqkiINKPSLLR 273
Cdd:COG0738 155 ---ILLGLSLSWHLPYLILAVLLLL--LALLFLRSKLPE---------------IEEEEEEAAGSA------ASLKSLLK 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 274 NRPLMAIIIVYCVFSLQEIAYNEIFSLWAVSdrsygGLSFSSQDVGEVLAISGLGLLVFQLLvYPPLEKSVGLLAVIRLS 353
Cdd:COG0738 209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD-----VLGLSEATAALGLSLFWGGMTIGRFL-GGFLLKRFGPVRLLRLS 282

                       330
                ....*....|
gi 42565446 354 AVLLIPLLSC 363
Cdd:COG0738 283 ALLAAVGLLL 292

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

78-189

4.74e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 67.23 E-value: 4.74e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG-CFNCLLGVIRAYASEV 156
Cdd:cd17489  33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGiGWGAFTTAAATLVADI 112

                        90       100       110
                ....*....|....*....|....*....|...
gi 42565446 157 VSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ 145

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

42-189

1.35e-11

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.06 E-value: 1.35e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  42 LVSLCTALPISSLFPYIYFMIRDFHIAKQEEDIGFyagfvgSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNT 121
Cdd:cd17323   6 FLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGV------SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42565446 122 LFGLSTSFWLAISVRFLLGCF-NCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17323  80 GCALAPNIAMLIILRFLQGFFgSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQ 148

MFS_SLC22A18

cd17331

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...

93-437

1.80e-11

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 65.70 E-value: 1.80e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  93 SIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLaISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTS 172
Cdd:cd17331  52 GPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPM-LFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLS 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 173 RGIGLILGPAIGGYLaqpaekypnifsqSSVFGRFPYFLPSLVISVYATAVLIACwwLPEtlhtrcriaqgrlNPTELND 252
Cdd:cd17331 131 YGIGMVVGSFLGGLL-------------TKKFGEQAAALVAAVGSLLSIVLVILL--IPS-------------NTKSKRE 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 253 DESRGGGLDEQKIINKPS--LLRNRPLMAIIIVYCVFSLQEIAYNEIFSLWAVsDRsyggLSFSSQDVGEVLAISGLGLL 330
Cdd:cd17331 183 KEAKESASPPSVFNLKEIlrLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAM-DF----FGLTPEENGYLMSYAGVLGM 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 331 VFQLLVYPPLEKSVGLLAVIRLSAVLLIpllSCYPYIALLSGVTLHLVINCASIIKNALSISLVTGlfiMLNKAVPQNQR 410
Cdd:cd17331 258 VVQGLLVGPLTKRFGERSLLKLSVALLA---IGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITS---LLTKAVPPEDT 331

                       330       340
                ....*....|....*....|....*..
gi 42565446 411 GAANGISMTAMSVFKSFGPAGGGVLFS 437
Cdd:cd17331 332 GTALGLSHALFSLVRTVSPTIGGALLQ 358

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

76-184

3.12e-11

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 64.52 E-value: 3.12e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  76 FYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG-CFNCLLGVIRAYAS 154
Cdd:cd17317  25 WLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGvTSAGIFTVGFVLGM 104

                        90       100       110
                ....*....|....*....|....*....|
gi 42565446 155 EVVSEEYNALSLSVVSTSRGIGLILGPAIG 184
Cdd:cd17317 105 EIVGPKYRSFVGILFGLFWALGYMLLALLA 134

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

75-438

4.17e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.56 E-value: 4.17e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  75 GFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPI-----ILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVI 149
Cdd:cd06173  33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPA 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 150 R-AYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAqpaekypnifsqsSVFGrfpYFLPSLVISVYATAVLIACW 228
Cdd:cd06173 113 RqALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-------------ALLG---PGGAFAINALSFLLSALLLL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 229 WLPETLHTRCRiaqgrlNPTELNDDESRGGGLdeqkiinkpSLLRNRPLMAIIIVYCVFSLQEIAYNEIFSLWAVSDrsy 308
Cdd:cd06173 177 FIRRPPPAAPG------ESSSLLLRDLREGLR---------YLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV--- 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 309 ggLSFSSQDVGEVLAISGLGLLVFQLLVyPPLEKSVGLLAVIRLSAVLL-IPLLScypyIALLSGVTLHLVincASIIKN 387
Cdd:cd06173 239 --LGGGAAGYGLLLAAFGVGALLGALLL-GRLSKRRRRGRLLLIGALLLgLALLV----LGLSPSLWLLLA---ALFLLG 308

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 42565446 388 ALSISLVTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAGGGVLFSW 438
Cdd:cd06173 309 LAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

78-187

1.22e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 63.14 E-value: 1.22e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGC-FNCLLGVIRAYASEV 156
Cdd:TIGR00895  54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEY 133

                          90       100       110
                  ....*....|....*....|....*....|.
gi 42565446   157 VSEEYNALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164

MFS_MFSD10

cd17389

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...

77-240

2.49e-10

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 61.91 E-value: 2.49e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  77 YAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEV 156
Cdd:cd17389  65 FGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 157 VSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAEKYpnifsqssvfGRFPYFLPSLVISVYATAVLIACW-WLPETLH 235
Cdd:cd17389 145 TSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSL----------GEVFFSMPALFALVLALADLLFIFfFLPETLP 214


                ....*
gi 42565446 236 TRCRI 240
Cdd:cd17389 215 SNLRR 219

PRK09874

multidrug efflux MFS transporter MdtG;

36-204

4.37e-10

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 61.47 E-value: 4.37e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   36 HLSFIWLVSLCTALPISSLFPYIYFMIRDFHIAKQEEdIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFS 115
Cdd:PRK09874  15 NLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSA-LNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  116 VIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAEKYP 195
Cdd:PRK09874  94 MGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRP 173


                 ....*....
gi 42565446  196 NIFSQSSVF 204
Cdd:PRK09874 174 VFFITASVL 182

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

85-189

7.08e-10

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 60.63 E-value: 7.08e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  85 FMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCL-LGVIRAYASEVVSEEYNA 163
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqESIERAAVADLVPAELRG 322

                        90       100
                ....*....|....*....|....*.
gi 42565446 164 LSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17370 323 TAYGLFNTVVGIGWLLASLIAGYLWD 348

PRK11102

Bcr/CflA family multidrug efflux MFS transporter;

83-240

4.72e-09

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 58.00 E-value: 4.72e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGV-IRAYASEVVSEEY 161
Cdd:PRK11102  33 SAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVvINALMRDMFPKEE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  162 NALSLSVVSTSRGIGLILGPAIGGYLAqpaekypNIFSQSSVFgrfpyflpsLVISVYA--TAVLIAcWWLPETLHTRCR 239
Cdd:PRK11102 113 FSRMMSFVTLVMTIAPLLAPIIGGWLL-------VWFSWHAIF---------WVLALAAilAAALVF-FFIPETLPKERR 175


                 .
gi 42565446  240 I 240
Cdd:PRK11102 176 Q 176

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

83-245

9.70e-09

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 57.33 E-value: 9.70e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCF---NCLLGVIraYASEVVSE 159
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGiggIWVQAVV--LNTEFLPK 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   160 EYNALSLSVVSTSRGIGLILGPAIGgylaqpaekypnifsqssvfgrfpYFLPS-----LVISVYATAVLIACWWLPETl 234
Cdd:TIGR00898 212 KQRAIVGTLIQVFFSLGLVLLPLVA------------------------YFIPDwrwlqLAVSLPTFLFFLLSWFVPES- 266

                         170
                  ....*....|.
gi 42565446   235 hTRCRIAQGRL 245
Cdd:TIGR00898 267 -PRWLISQGRI 276

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

37-473

2.17e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.04 E-value: 2.17e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  37 LSFIWLVSLCTALPISSLFPYIYFMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSV 116
Cdd:COG2223   7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQ------LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 117 IIFNTLFGLSTSFWLAISVRFLLGCFN-CLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekyp 195
Cdd:COG2223  81 GIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA------ 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 196 nifsqssVFG-RFPYFLPSLVISVyataVLIACWWLpetlhtrcriaqgrlnpteLNDDESRGGGLDEQKIINKPSLLRN 274
Cdd:COG2223 155 -------AFGwRNAFLILGILLLV----VAVLAWLF-------------------LRDPPAGAAAAAKASLRDQLEALRD 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 275 RPLMAIIIVYCVFSLQEIAYNEIFSLWAVSdrsygGLSFSSQDVGEVLAISGLGLLVFQLL---VYPPLEKSVGLLAVIR 351
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVD-----QFGLSAATAGLLAALFALLGALGRPLggwLSDRIGGRRVLLIVFA 279

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 352 LSAVLLIPLLscYPYIALLSGVTLHLVINCASIIKNALSISLVTGLFimlnkavPQNQRGAANGISMTAMSVFKSFGPAG 431
Cdd:COG2223 280 LMALGLLLLA--LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF-------PTKNAGAVYGLVGAAGGLGGFLGPLL 350

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 42565446 432 GGVLFSWAQKRQdatflpgdeMVFLVLNLVQLVGLILTFIPY 473
Cdd:COG2223 351 FGALLDATGSYT---------AAFLVFAVLALVALVLTLLLY 383

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

78-189

3.77e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 55.26 E-value: 3.77e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGR--KPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCF-NCLLGVIRAYAS 154
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGlGGAFGLLWALAA 297

                        90       100       110
                ....*....|....*....|....*....|....*
gi 42565446 155 EVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

81-189

4.09e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 55.26 E-value: 4.09e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  81 VGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGC-----FNCLLGVIRAYase 155
Cdd:cd17321  36 VVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIgaaaiMPASLALIAAT--- 112

                        90       100       110
                ....*....|....*....|....*....|....
gi 42565446 156 vVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17321 113 -FPGERRGRALGLWGAVVGIGAALGPLLGGLLLE 145

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

78-187

4.54e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.92 E-value: 4.54e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG-CFNCLLGVIRAYASEV 156
Cdd:cd17316  38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGiGIGGEYPGASTYVAEF 117

                        90       100       110
                ....*....|....*....|....*....|.
gi 42565446 157 VSEEYNALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:cd17316 118 APSKRRGFALGLLQSGWALGALLAALVASLL 148

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

41-140

1.28e-07

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.40 E-value: 1.28e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  41 WLVSLCTALPISSLFPYIYFMIRDFHIAKQEedIGFYAGFVGssfmIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFN 120
Cdd:cd17475   2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQ--VGLLLSALN----LGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAA 75

                        90       100
                ....*....|....*....|
gi 42565446 121 TLFGLSTSFWLAISVRFLLG 140
Cdd:cd17475  76 LLMALVGSYPVLLVLLFLVG 95

efflux_Bcr_CflA

TIGR00710

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...

83-243

1.86e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.

Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 53.16 E-value: 1.86e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVI-RAYASEVVSEEY 161
Cdd:TIGR00710  47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVIsQALVRDIYPGEE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   162 NALSLSVVSTSRGIGLILGPAIGGYLAQpaekypnIFSQSSVFgrfpyflpsLVISVYATAVLIACWWL-PETLHTRCRI 240
Cdd:TIGR00710 127 LSRIYSILMPVLALAPAVAPLLGGYILV-------WLSWHAIF---------AFLSLAGILLSALIFFIlPETLPYEARI 190


                  ...
gi 42565446   241 AQG 243
Cdd:TIGR00710 191 QIS 193

MFS_SLC46

cd17386

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...

90-187

2.37e-07

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 52.67 E-value: 2.37e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  90 ALTSIFWGKLADRYGRKPIILIG------TFSVIIFNTLFGLSTSFWLAISVRFLLGCFN---CLLGVIRAYASEVVSEE 160
Cdd:cd17386  44 LFSSLFLGSWSDRYGRKPPLLMSlvglllSSLILVLIVYFTTVPSVWWFYLSAIPLALFGgftAFLSASFAYISDISSEK 123

                        90       100
                ....*....|....*....|....*..
gi 42565446 161 YNALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHL 150

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

54-437

2.47e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 52.58 E-value: 2.47e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  54 LFPYIYFMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAI 133
Cdd:cd17504  15 LSPALPTIQREFGTSAAA------VSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 134 SVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQpaekypnIFSQSSVFgrfpyflps 213
Cdd:cd17504  89 AGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQ-------HLGWRWIF--------- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 214 LVISVYATAVLIACwwlpetlhtrcriaqgrlnptelnddesrgggldeqKIINkPSLLRNRPLMAIIIVYCVFSLQEIA 293
Cdd:cd17504 153 WTAAPVAVLLAALV------------------------------------PLID-LRLLRRRNVLLANITALLAGFGMFM 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 294 YNEIFSLWAVSDRSYGGLsFSSQDVGEVLAISGLGLLVFqllvyPPLeksVGLLAVIRLSAVLLIP--LLSCYPYIALLS 371
Cdd:cd17504 196 VFQLLPQLLQLPTPTGFG-LGITEAGLLLLPGALVMLIA-----GPL---AGRLIARVGPRRVLLIglVISAVGLLLLAL 266

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565446 372 GVTLHLVINCASIIKNALSISLVTGLFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAGGGVLFS 437
Cdd:cd17504 267 LHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

78-438

2.86e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.56 E-value: 2.86e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGV-IRAYASEV 156
Cdd:cd17477  33 IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVvSESWLNAL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 157 VSEEYNALSLSVVSTSRGIGLILGPAIGGylaqpaekypnifsqssVFGRFPYFLPSLVISVYATAVLIACWwlpetlht 236
Cdd:cd17477 113 ATNENRGRVLGLYSTVLGLGFALGPLLLA-----------------LVGTAGALPFLIAAVLLLLALVPLLL-------- 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 237 rcriaqGRLNPTELNDDESRGGGLdeqkiinkpsLLRNRPLMAIIIVycVFSLQEIAYNEIFSLWAVSdrsyggLSFSSQ 316
Cdd:cd17477 168 ------TRRAAPEIEEAESISLRR----------LLRIAPLALLGAF--VAGFLEGAFYSLLPLYGLR------LGLSVA 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 317 DVGEVLAISGLGLLVFQLLVyPPLEKSVGLLAVIRLSAVLLIPLLscypyIALLSGVTLHLVINCASIIKNALSISLVTG 396
Cdd:cd17477 224 QAALLLAAFVLGGLLLQWPL-GWLADRFDRRRVLLGCALLGALAA-----LLLPLVPGLPLALLVLLFLWGGAAGPLYTL 297

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 42565446 397 LFIMLNKAVPQNQRGAANGISMTAMSVFKSFGPAGGGVLFSW 438
Cdd:cd17477 298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDA 339

Sugar_tr

pfam00083

Sugar (and other) transporter;

69-298

5.11e-07

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 51.89 E-value: 5.11e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    69 KQEEDIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLST---SFWLAISVRFLLGCF-NC 144
Cdd:pfam00083  39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGvGG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   145 LLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGgylaqpaekYPNIFSQSSVFGRFPYFLpslvISVYATAVL 224
Cdd:pfam00083 119 ASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFG---------LGLNKTSNSDGWRIPLGL----QLVPALLLI 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   225 IACWWLPET---LHTRCRIAQGR-----LNPTELND-------DESRGGGLDEQKIINKPSLLRNRPLMAIIIVYCVFSL 289
Cdd:pfam00083 186 IGLLFLPESprwLVEKGRLEEARevlakLRGVPDVDreldeikDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQ 265


                  ....*....
gi 42565446   290 QEIAYNEIF 298
Cdd:pfam00083 266 QLTGINAIF 274

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

69-189

6.29e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.47 E-value: 6.29e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  69 KQEEDIG-FYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG----CFN 143
Cdd:cd17328  26 QSDFLIDdSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGigeaSYS 105

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 42565446 144 CLLGvirAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17328 106 PIAP---TIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQ 148

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

78-189

6.57e-07

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 51.03 E-value: 6.57e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNC-LLGVIRAYASEV 156
Cdd:cd17502  32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGgLMSLAFIIIADL 111

                        90       100       110
                ....*....|....*....|....*....|...
gi 42565446 157 VSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17502 112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD 144

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

40-438

7.35e-07

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 7.35e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALPISSLFPYIYFMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIF 119
Cdd:COG2807  23 IVLVALNLRPAITSVGPLLPEIRADLGLSATQ------AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 120 NTLFGLSTSFWLAISVRFLLG-----CFNCLLGVIRAYASEVVseeynALSLSVVSTSRGIGLILGPAIGGYLAQpaeky 194
Cdd:COG2807  97 LLLRSLAPSVALLLAGTALIGagiavGNVLLPGLIKRWFPDRV-----GLMTGLYTAAMGLGAALAAGLTVPLAA----- 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 195 pnifsqssVFGrfpyFLPSLVISVYATAVLIACWWLpetlhtrcriaQGRLNPTELNDDESRGGGldeqkiinkPSLLRN 274
Cdd:COG2807 167 --------ALG----WRGALAVWALLALLALLLWLP-----------LLRRRPAAAAAAPAAASL---------RSLWRS 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 275 RPLMAIIIVYCVFSLqeIAYneIFSLWAVSdrSYGGLSFSSQDVGEVLAISGLGLLVFQLLVyPPLEK----------SV 344
Cdd:COG2807 215 PLAWLLTLFFGLQSL--LYY--AVVAWLPP--ILRDAGLSAATAGLLLSLFQLAGIPGSLLV-PLLADrlgdrrplllLL 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 345 GLLAVIRLSAVLLIPLLSCYPYIALLSGvtlhlvincasiiknALSISLVTGLFIMLNKAVPQNQRGAANGISMTAMSVF 424
Cdd:COG2807 288 GLLGLAGLLGLLLAPGSLPWLWAVLLGL---------------GQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLL 352

                       410
                ....*....|....
gi 42565446 425 KSFGPAGGGVLFSW 438
Cdd:COG2807 353 AALGPLLVGALHDA 366

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

60-188

1.24e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 50.26 E-value: 1.24e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  60 FMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLL 139
Cdd:cd17319  28 TIMKDLGLSPTQ------YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 42565446 140 GCFN--CLLGVIRAYAsEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLA 188
Cdd:cd17319 102 GVAEagFFPGAIKALA-EWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL 151

MFS_MFSD8

cd17326

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...

79-227

1.34e-06

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 50.29 E-value: 1.34e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  79 GFVGSSFMIGRALTSIFWGKLADRYG-RKPIILIGTFSVIIFNTLFGLSTSF-----WLAISVRFLLGCFNCLLGVIRAY 152
Cdd:cd17326  39 GWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFpsnrkYVMLVARFLIGVGAGNVAVLRAY 118

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42565446 153 ASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAEKYPNIFsqssvfgrfpyflPSLVISVYATAVLIAC 227
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPGYVIG-------------IKLRFNMYTAPAWLMA 180

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

39-237

1.34e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.34e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  39 FIWLVSLCTALPISSLFPY-IYFMIRDFHIAKQeedigfYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVI 117
Cdd:COG2211 232 LLLLAYLLFFLALALVAALlLYYFKYVLGLSAA------LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 118 IFNTLFGLS--TSFWLAISVRFLLGCFN-CLLGVIRAYASEVVSEEY-------NALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:COG2211 306 LGLLLLFFLgpGNLWLLLVLAALAGIGLgAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLL 385

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 42565446 188 AQPAEKYPNIF-SQSSVFGRFPYFLPSLVISVYATAVLIACWWLPETLHTR 237
Cdd:COG2211 386 LALFGYVAGAAqSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

77-140

1.65e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 49.88 E-value: 1.65e-06

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42565446  77 YAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG 140
Cdd:cd17315  35 LQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLG 98

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

37-189

2.54e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 49.93 E-value: 2.54e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  37 LSFIWLVSLCTalpISSLFPYIYFMIRDFHIAKQeedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSV 116
Cdd:cd06179   3 LCLAYFAQLFG---VTLPAAVLPFIVADLGPSSN-------STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLG 72

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42565446 117 IIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd06179  73 VVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVE 145

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

82-187

4.70e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 48.75 E-value: 4.70e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  82 GSSFMIGRAL------TSIF---WGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCfNCLLGVIRAY 152
Cdd:cd17472  29 ATPTLIGLALgiygltQAIFqipFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAISSVVMAL 107

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 42565446 153 ASEVVSEEYNALSLSVVSTSRGI----GLILGPAIGGYL 187
Cdd:cd17472 108 LADLTREENRTKAMALIGASIGIafaiSMVLGPLLAAHL 146

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

40-198

6.37e-06

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.36 E-value: 6.37e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALpISSLFPYIYFMIRDFHIAKQEEDIGFYAGFVGSSFMIGRaltsIFWGKLADRYGRKPIILIGTFSVIIF 119
Cdd:cd17489 196 VLPPALILFL-ASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSR----PFSGKLSDRKGPKTVIIPGLLLLALG 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 120 NTLFGLSTSFWLAISVRFLLGC-FNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAEkYPNIF 198
Cdd:cd17489 271 LLLLSFAGSPWMLLLAAVLYGLgFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMF 349

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

83-140

6.73e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 48.06 E-value: 6.73e-06

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42565446  83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG 140
Cdd:cd17374  42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAG 99

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

30-184

8.63e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 8.63e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  30 RGVPYLHLSFIWLVSLCTALPISSLFPYIYFMIRDFHIAKQeedigfYAGFVGSSFMIGRALTSIFWGKLADRYGRKPII 109
Cdd:cd17478 190 LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLV------FAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI 263

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565446 110 LIGTFSVIIFNTLFGLSTSFWLAISVrFLLGCFNCL-LGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIG 184
Cdd:cd17478 264 IASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFAsFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLG 338

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

37-188

1.02e-05

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.64 E-value: 1.02e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  37 LSFIWLVSLCTALPISSLFpyiyfmIRDfhIAKQEEDIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSV 116
Cdd:cd17391 209 TTFIIQLANQSIEPILTLY------IRQ--LMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLAS 280

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42565446 117 IIFNTLFGLSTSFWLAISVRFLLG-CFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLA 188
Cdd:cd17391 281 ALLYIPQAFVQTPWQLGILRFLLGlATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIA 353

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

60-140

1.02e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.56 E-value: 1.02e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  60 FMIRDFHIAKQEEdigfyaGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLL 139
Cdd:cd17359  26 FLQTDFNLTPFLE------GLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIG 99


                .
gi 42565446 140 G 140
Cdd:cd17359 100 G 100

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

40-189

1.16e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 1.16e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  40 IWLVSLCTALPISSLFPYIYFMIRDFHiakqeEDIGFYAGFVGS--SFMIgrALTSIFWGKLADRYGRKPIILIGTFSVI 117
Cdd:cd17473   4 LLLASTLTVMAGAAIAPALPAIAQHFV-----PNSELLVPLLLTlpALFI--ALFAPLAGWLADRFGRKRLLIAGLLLYG 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42565446 118 IFNTLFGLSTSFWLAISVRFLLGC-----FNCLLGVIRAYASEvvSEEYNALSLSVVSTSrgIGLILGPAIGGYLAQ 189
Cdd:cd17473  77 IGGVAGLFLDSLYALLASRALLGIgvagiMTLATALIGDYFEG--EERAKMLGLQSAAMS--LGGVVFLLLGGALAE 149

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

78-187

1.56e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.78 E-value: 1.56e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTF--SVIIFNTLFGLSTSFWLAISVRFLLG-----CFNCLLGVIr 150
Cdd:cd17380  36 QGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVAlwSLATLLTPLLAYSSLPLLILSRILLGlgegvHFPSMTSLF- 114

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 42565446 151 ayaSEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:cd17380 115 ---SRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLL 148

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

39-189

1.57e-05

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.57e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  39 FIWLVSLCTALP---ISSLFPYIYFMIRDFHIAKqeedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFS 115
Cdd:cd17316 181 LLILLWFFISFGyygLTTFLPTYLQTVLGLSPAT--------SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565446 116 VIIFNTLFG--LSTSFWLAISVRFLLGCFNCLL-GVIRAYASEVVSEEYNALSLSVV-STSRGIGLILGPAIGGYLAQ 189
Cdd:cd17316 253 SGILALPLFylLSGSPTLLLLLLFILSFFVGGVwGALYAYLAELFPTEVRATGVGLSyNLGRLGGGGAPPLIALLLAS 330

MFS_SLC22A15

cd17377

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...

79-229

1.78e-05

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 46.70 E-value: 1.78e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  79 GFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIR-AYASEVV 157
Cdd:cd17377  42 SLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAfVLLNECV 121

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42565446 158 SEEYNALSLSVVSTSRGIGLILGPAIGGYLaqpaEKYPNIFSQSSVFGRFpYFLPSLVISvYATAVLIACWW 229
Cdd:cd17377 122 GKSYWALAGSLGGLFFAVGIAQYALLGYFI----RSWRTLAVVVNLQGTL-VFLLSLFIP-GRTLILMYVWF 187

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

78-188

1.84e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 1.84e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFL--LGCFNCLLGVIrAYASE 155
Cdd:cd17365  36 LGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLtgLGLGAAMPNAI-TLVSE 114

                        90       100       110
                ....*....|....*....|....*....|...
gi 42565446 156 VVSEEYNALSLSVVSTsrgiGLILGPAIGGYLA 188
Cdd:cd17365 115 YAPARRRSLAVTLMFC----GYPLGAALGGFLA 143

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

59-183

3.31e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.83 E-value: 3.31e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    59 YFMIRDFHIAKQE--EDIGFYA---GFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAI 133
Cdd:TIGR00881   8 YLVRKNFALAMPYlvEEIGLSKtdlGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 42565446   134 SVRFLLGCFNCLLGVI--RAYASEVVSEEYnALSLSVVSTSRGIGLILGPAI 183
Cdd:TIGR00881  88 ALWALNGIFQGMGWPPcgRTVTKWFSRSER-GTWVSFWNCSHNVGGGLLPPL 138

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

78-188

3.39e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.20 E-value: 3.39e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPI----ILIGTFSVIIFNTLFglstSFWLAISVRFLLGCF-NCLLGVIRAY 152
Cdd:TIGR00895 287 AATGGALFNFGGVIGSIIFGWLADRLGPRVTalllLLGAVFAVLVGSTLF----SPTLLLLLGAIAGFFvNGGQSGLYAL 362

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 42565446   153 ASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLA 188
Cdd:TIGR00895 363 MALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

74-179

4.13e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.76 E-value: 4.13e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  74 IGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGC-FNCLLGVIRAY 152
Cdd:cd17371  32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLgFGGEWAAGAAL 111

                        90       100
                ....*....|....*....|....*..
gi 42565446 153 ASEVVSEEYNALSLSVVSTSRGIGLIL 179
Cdd:cd17371 112 MAEYVPARHRGKALGYVQSGWAVGWLL 138

MFS_OFA_like

cd17353

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...

39-189

4.96e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.29 E-value: 4.96e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  39 FIWLVSLCTALPISSLFPYIYFMIRDFHIAkqeedIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIgTFSVII 118
Cdd:cd17353 217 LLWLMFFLNATAGLMLIGQAKPIGQEFAGL-----DAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSI-AFLIQG 290

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42565446 119 FNTL---FGLSTSFWLAISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17353 291 VAMFllpFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY 364

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

78-473

5.00e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 5.00e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGR---ALTSIFWGKLADRYG-----RKPIILIGT-----FSVIIFNT-LFGLSTSFWLAISVRFLLG-CF 142
Cdd:COG2211  45 AALVGLILLVARlwdAITDPLIGALSDRTRtrwgrRRPWILIGAiplalSFVLLFTApDLSPTGKLIYALVTYLLLGlAY 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 143 NCLLGVIRAYASEVVSEEYNALSLSVVstsRGIGLILGPAIGGYLAQPAEKYpniFSQSSVFGRFPYFLpsLVISVYATA 222
Cdd:COG2211 125 TLVNIPYSALGAELTPDYEERTRLSSW---RFAFAGLGGLLASVLPPPLVAA---FGGDAALGYRLTAL--IFAVLGLLA 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 223 VLIACWWLPETLHTRcriaqgrlnptelnddESRGGGLDEQKiinkpSLLRNRPLMAIIIVYCVFSLQEIAYNEIFSLWA 302
Cdd:COG2211 197 FLLTFFGTKERPVPE----------------EEKVSLKESLK-----ALLKNRPFLLLLLAYLLFFLALALVAALLLYYF 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 303 VSDrsyggLSFSSQDVGEVLAISGLGLLVFQLLVyPPLEKSVGLLAVIRLSAVLLIpLLSCYPYIALLSGVTLHLVINCA 382
Cdd:COG2211 256 KYV-----LGLSAALVGLLLALYFLAALLGAPLW-PRLAKRFGKKKAFIIGLLLAA-LGLLLLFFLGPGNLWLLLVLAAL 328

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 383 SIIknALSISLVTgLFIMLNKAVP-------QNQRGAANGISMTAMSVFKSFGPAGGGVLFSW----AQKRQDATFLPGD 451
Cdd:COG2211 329 AGI--GLGAILVL-PWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALfgyvAGAAQSPSALTGI 405

                       410       420
                ....*....|....*....|..
gi 42565446 452 EMVFLVLNLVQLVGLILTFIPY 473
Cdd:COG2211 406 RLLFFLLPAVLLLLAALLLLFY 427

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

81-187

5.80e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.26 E-value: 5.80e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  81 VGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVI-RAYASEVVSE 159
Cdd:cd17503  36 VITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLaQTILLRIYPP 115

                        90       100
                ....*....|....*....|....*...
gi 42565446 160 EYNALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:cd17503 116 EKRGAAMGLVGLVILLAPAIGPTLGGWL 143

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

42-468

6.28e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 6.28e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  42 LVSLCTALPISSLFPYI-YFMIRDFHIAKqeedigFYAGFvgssFMIGRALTSI----FWGKLADR-YGRKPIILIGTFS 115
Cdd:cd17471   3 LATLLTGLAGAFVLPYLsLFLTEELGASP------LQIGI----FMTLSALSGIvvsqWLGRLSDRgGDRKPLILLALLA 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 116 VIIFNTLFGLSTSFWLAISVRFLLG-----CFNCLLGVIRAYASEVVSEEyNALSLSVVSTSRGIGLILGPAIGGYLAqp 190
Cdd:cd17471  73 GALGYLLFAFLRNYWVLLLVGVVLLslgaaAFPQLFALAREYADRSSGRD-ATLFNSVLRAAFSLAWVIGPPLAFLLL-- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 191 aekypnifsqsSVFGRFPYFLPSLVISVyatAVLIACWWLPETLHTRcRIAQGRLNPtelnddesrgggldeqkiinKPS 270
Cdd:cd17471 150 -----------DVLGFTGLFLLAALLYL---VVALLVLFLLPSVKPP-AQKATPASS--------------------LVK 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 271 LLRNRPLMAIIIVYCVFSLQEIAYNEIFSLWAVSDrsyggLSFSSQDVGEVLAISGLGLLVFQLLvyppleksVGLLAV- 349
Cdd:cd17471 195 APVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNE-----LGGSESWVGLLFGLAAALEIPIMLL--------AGLLAKr 261

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 350 IRLSAVLLIPLLSCYPYIALLSGVT-LHLVIncASIIKNALSISLVTGLFI-MLNKAVPqNQRGAANGISMTAMSVFKSF 427
Cdd:cd17471 262 FGKRRLLLAGFLAGVLFYLGLALATsLWQLI--ALQLLNAIFIGITAGLGIsYFQDLMP-GQPGLATTLYSNASRIGSLL 338

                       410       420       430       440
                ....*....|....*....|....*....|....*....|.
gi 42565446 428 GPAGGGVLFSWAQKRqdatflpgdeMVFLVLNLVQLVGLIL 468
Cdd:cd17471 339 GGLLAGVIAQYFGYR----------AVFLVCAVLALLALVL 369

MFS_YdiM_like

cd17396

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...

80-146

1.32e-04

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 44.26 E-value: 1.32e-04

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42565446  80 FVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFntLFG--LSTSFWLAISVRFLLGCFNCLL 146
Cdd:cd17396  39 YVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALF--FVGilFSPNLIIAYVFALLAGAANSFL 105

PRK11551

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional

61-192

1.39e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional

Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.18 E-value: 1.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   61 MIRDFHIAKQEEDIGFYAGfvgssfMIGRALTSIFWGKLADRYGRKPIILigtFSVIIFNtLFGLST----SFWLAISVR 136
Cdd:PRK11551  41 MAQEFGLDVAQMGWAFSAG------ILGLLPGALLGGRLADRIGRKRILI---VSVALFG-LFSLATaqawDFPSLLVAR 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 42565446  137 FL--LGCFNCLLGVIrAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAE 192
Cdd:PRK11551 111 LLtgVGLGGALPNLI-ALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAA 167

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

60-189

2.05e-04

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.69 E-value: 2.05e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  60 FMIRDFHIAkqEEDIGFYAGFVGSSFMIGRALTsifwGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLL 139
Cdd:COG0738 236 YLKDVLGLS--EATAALGLSLFWGGMTIGRFLG----GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 42565446 140 GCFNCLL-GVIRAYASEVVsEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:COG0738 310 GLGLSLMfPTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLAD 359

MFS_MFSD6

cd17335

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...

51-144

2.17e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.34 E-value: 2.17e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  51 ISSLFPY--IYFmirdfhiakqeEDIGFYA---GFVGSSFMIGRALTSIFWGKLADRYG-RKPIILIGTFSVIIFNTLFG 124
Cdd:cd17335  13 LGSLLPFlsVYL-----------KQLGLSPtqiGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLF 81

                        90       100
                ....*....|....*....|.
gi 42565446 125 L-STSFWLAISVRFLLGCFNC 144
Cdd:cd17335  82 FvAQIFWLLLLLVILGAFFSA 102

MFS_OPA_SLC37

cd17312

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...

59-189

2.26e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.42 E-value: 2.26e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  59 YFMIRDFHIAKQE--EDIGFYA---GFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAI 133
Cdd:cd17312  16 YVCRKNFSVAKPPivEEIGLSKddlGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFA 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42565446 134 SVRFLLGCF------NCLLGVIRAYAsevvSEEYnALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17312  96 VLWGLNGLFqsmgwpPCVKLLGNWFS----KKER-GTVYGIWSTSHNFGGILAPILAASLAS 152

PRK12307

MFS transporter;

78-140

2.84e-04

MFS transporter;

Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 42.99 E-value: 2.84e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42565446   78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG 140
Cdd:PRK12307  55 GAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVG 117

MFS_OCT_plant

cd17378

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...

76-142

3.01e-04

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 42.73 E-value: 3.01e-04

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565446  76 FYAGFVGSSFMIGRALTSIFWGKLAD-RYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCF 142
Cdd:cd17378  33 FLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFG 100

2A0121

TIGR00900

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]

86-437

3.17e-04

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 42.69 E-value: 3.17e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    86 MIGRALTSIFWGKLADRYGRKPIILIG-------TFSVIIFNTLFGLStsFWLAISVRFLLGCFNCLLGVIR-AYASEVV 157
Cdd:TIGR00900  44 MLPYVVLSPIAGALADRYDRKKVMIGAdliravlVAVLPFVALLGGLN--IWQVYVLAGILAIAQAFFTPAYqAMLPDLV 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   158 SEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAEKYPNIFSQssvfgrfpyflpslVISVYATAVLIAcwwlpetlhtR 237
Cdd:TIGR00900 122 PEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVD--------------AVGFAISALLIV----------S 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   238 CRIAQGRLNPTELNDDESRGGGLDEQKIInkpslLRNRPLMAIIIVYCVFSLQEIAYNEIFSLWAVSDRsyggLSFSSQD 317
Cdd:TIGR00900 178 VRIPELAASEIQALSNAVLRDTREGIKFV-----LKNPLLRTLLLLALLFNLVFAPAIVALFPYVQSKY----LGRGSTH 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   318 VGEVLAISGLGLLVFQLLVyPPLEKSVGLLAVIRLSAVLL-IPLLScypyIALLSGVTLHLVINCASIiknALSISLVTG 396
Cdd:TIGR00900 249 YGWVLAAFGLGALLGALLL-GLLGRYFKRMALMTGAIFVIgLAILV----VGLTPPNFPLFLVLWFAI---GVGYGPINV 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 42565446   397 LFI-MLNKAVPQNQRGAANGISMTAMSVFKSFGPAGGGVLFS 437
Cdd:TIGR00900 321 PQGtLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLAD 362

PRK10473

MdtL family multidrug efflux MFS transporter;

83-184

3.77e-04

MdtL family multidrug efflux MFS transporter;

Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 42.70 E-value: 3.77e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG-----CFNCLLGVIRayasEVV 157
Cdd:PRK10473  45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGigagcCYVVAFAILR----DTL 120

                         90       100
                 ....*....|....*....|....*..
gi 42565446  158 SEEYNALSLSVVSTSRGIGLILGPAIG 184
Cdd:PRK10473 121 DDRRRAKVLSLLNGITCIIPVLAPVLG 147

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

78-187

5.29e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 5.29e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG-CFNCLLGVIRAYASEV 156
Cdd:cd17333  33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGlGAGILDTGANTFVGAL 112

                        90       100       110
                ....*....|....*....|....*....|.
gi 42565446 157 VSEEYNALsLSVVSTSRGIGLILGPAIGGYL 187
Cdd:cd17333 113 FEESSATR-LNVLHGFFGLGALIGPLIATSL 142

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

37-216

5.77e-04

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 5.77e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  37 LSFIWLVSLCTALPISSLFP-YIYFMIRDFHIAKQeeDIGFYAGFVGSSFMIGRALtsiFWGKLADRYGRKPIILIGTFS 115
Cdd:cd17330 176 LRRLLLVYFLIALAFAGLESvFSLFLKDRFGFSPS--QIGLLLALVGIAGILAQLL---LIPRLAKRLGERKLLRLGLLL 250

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 116 VIIFNTLFGLSTSFWLAISVRFLLGCFNCLLG-VIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLaqpaeky 194
Cdd:cd17330 251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFpALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL------- 323

                       170       180
                ....*....|....*....|..
gi 42565446 195 pnifsQSSVFGRFPYFLPSLVI 216
Cdd:cd17330 324 -----YSFLGPGVPFLLAAGLL 340

MFS_SLC22A7_OAT2

cd17447

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...

85-140

6.75e-04

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 41.64 E-value: 6.75e-04

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 42565446  85 FMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG 140
Cdd:cd17447  44 FFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTG 99

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

78-205

7.38e-04

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 7.38e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGC-FNCLLGVIRAYASEV 156
Cdd:cd17473 235 IGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSL 314

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 42565446 157 VSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQPAEKYPNIFSQSSVFG 205
Cdd:cd17473 315 VPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLA 363

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

78-187

7.98e-04

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.45 E-value: 7.98e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYG---RKPIILIGTFSVIIFNTLFGL---STSFWLAISVRFLLGCFNCLL-GVIR 150
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLlspGTPLWLLVLLLILLGLFAIGWnGLYL 315

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 42565446 151 AYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:cd17475 316 TLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLL 352

MFS_SLC45_SUC

cd17313

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...

83-358

8.13e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.84 E-value: 8.13e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  83 SSFMIGRALTSIFW--------------GKLADR----YG-RKPIILIGTFSVIIFNTLFGLSTSFWLA----------- 132
Cdd:cd17313  27 QTLGLSHALIGFVWtlgpilglfvqplvGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAADIGLAlgdgprtwalv 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 133 ---ISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLaqpaekypnifsqsSVFGRFPY 209
Cdd:cd17313 107 lfvLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAIL--------------WDHNWFGF 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 210 FLPSLVISVYATAVLIacwWLPETLHTRCRIAQGRLNPTELNDDESRGGGLDEQKIInkpSLLRNRPLMAIIIVYCVFsL 289
Cdd:cd17313 173 ALGGNLKVPFYIGAII---LLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLL---KLLKIMPRSLLRLLLVIF-F 245

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565446 290 QEIAYNEI---FSLWaVSDRSYGGLSFSSQDVGEVLAISGLGLLVFQL------LVYPPLEKSVGLLAVIRLSAVLLI 358
Cdd:cd17313 246 WWIAFFPFelfFTDY-MGEEVYHGTSAASSHYGAGVRMGAWGLLIFSLaflifsLPIGKLGKKIGRKKVYLIGLVLFA 322

MFS_GLUT6_8_Class3_like

cd17358

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...

78-233

1.00e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.41 E-value: 1.00e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG-CFNCLLGVIRAYASEV 156
Cdd:cd17358  43 FSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGfGGGAASVVVPVYIAEI 122

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42565446 157 VSEEYNALSLSVVSTSRGIGLILGPAIGGYLaqpaekypnifsqssvfgrfPYFLPSLVISVYATAVLIACWWLPET 233
Cdd:cd17358 123 APKNVRGALGSLNQLLVNIGILLGYVLGSFL--------------------PWRTLALIGAIPPVVFLILLFFIPES 179

emrD

PRK11652

multidrug transporter EmrD;

91-234

1.03e-03

multidrug transporter EmrD;

Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 41.43 E-value: 1.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   91 LTSIFWGKLADRYGRKPIILIGtFSVIIFNTLFGL-STSFWLAISVRFLLGCFNcllGVIRAYASEVVSEEYNALSL--- 166
Cdd:PRK11652  58 LSQLFYGPLSDRVGRRPVILVG-MSIFILGTLVALfAHSLTVLIAASAIQGLGT---GVGGVMARTLPRDLYEGTQLrha 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42565446  167 -SVVSTSRGIGLILGPAIGGYLAqpaekypNIFSQSSVFgrfpYFLPSLVISVyataVLIACWWLPETL 234
Cdd:PRK11652 134 nSLLNMGILVSPLLAPLIGGLLT-------TLFGWRACY----LFLLLLGAGV----TFSMARWMPETR 187

MFS_SLC22A1_2_3

cd17379

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...

83-187

1.17e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 41.18 E-value: 1.17e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  83 SSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCF---NCLLGVIraYASEVVSE 159
Cdd:cd17379  40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFgkgGWMTGYV--LVTEFVGS 117

                        90       100
                ....*....|....*....|....*...
gi 42565446 160 EYNALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:cd17379 118 KYRRTVGIVYQMFFTLGLLILPGIAYFI 145

MFS_MFSD14

cd17387

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...

91-187

1.23e-03

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 41.25 E-value: 1.23e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  91 LTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVrfLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVS 170
Cdd:cd17387  51 LSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMIS--VSGIFSVTFSVIFAYVADITTEEERSTAYGLVS 128

                        90
                ....*....|....*..
gi 42565446 171 TSRGIGLILGPAIGGYL 187
Cdd:cd17387 129 ATFAASLVTSPALGAYL 145

MFS_ShiA_like

cd17369

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...

77-155

1.30e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 1.30e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  77 YAGFVGSSFMIgraLTSIFWGKLADRYGRKPIILIGT-FSVIIFNTLFGL--STSFWLAISVR-FLLGCFNCLL-GVIRA 151
Cdd:cd17369 268 LAVLIASVVAA---ITIPLFGWLSDRVGRRPVYLAGAlLAALFAFPFFWLldTGSTWLIVLAAvVVLGVLHGMMyGPQAA 344


                ....
gi 42565446 152 YASE 155
Cdd:cd17369 345 FLAE 348

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

52-434

1.37e-03

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 1.37e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  52 SSLFPYIYFMIRDFHIAKQEedigfyAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWL 131
Cdd:cd17478  13 GFLPALLPLLIAKLGLSYAQ------AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 132 AISVRFLLGCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLaqpaekypniFSQSSVFGRFPYFL 211
Cdd:cd17478  87 LLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL----------VALFGGLGLLILLI 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 212 PSLVISVyatavLIACWWLPETLHTRCRIAQGRLNPtelnddesrgggldeqkiinkpsLLRNRPLMAIIIVYCVFSLQE 291
Cdd:cd17478 157 IPGLAVA-----LLLLRLRPLKKPEAKKAAAKSSAR-----------------------STLKGVWRALLLLLIIVFLRS 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 292 IAYNEIFSLwavsdrsyggLSFSSQDVGEVLAISGLGLLVFQL------LVYPPLEKSVGLLAVIRLSAVLLIPLLscyP 365
Cdd:cd17478 209 WVLSSLTTF----------LPFYLVQRGYSLVFAGLLLSLFLFagaigtLIGGPLSDRFGRRRVIIASLLLAAPFL---L 275

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 366 YIALLSGVTLHLVINCASIIKNA-LSISLVTGlfimlNKAVPQNqRGAANGISMTAmsvfkSFGPAGGGV 434
Cdd:cd17478 276 LFLLTPGIWSYILLVLAGFLLFAsFPVTVVLA-----QELLPGN-VGLASGLMMGL-----SFGLGGIGA 334

MFS_FucP_like

cd17394

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...

76-187

1.60e-03

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 40.67 E-value: 1.60e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  76 FYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLF---GLSTSFWLAISVRFLLGCFNCLLGV-IRA 151
Cdd:cd17394  34 FQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALLFipaASLRTYGLFLIALFVLASGLALLQTaANP 113

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 42565446 152 YASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYL 187
Cdd:cd17394 114 YVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYL 149

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

76-185

1.75e-03

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.62 E-value: 1.75e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  76 FYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVII---FNTLFGLSTSFWLAISVRFLLGC-FNCLLGVIRA 151
Cdd:cd17321 204 LQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVgllLLALLGADSSVWLLLPGLVLLGLgLGLFATPLTN 283

                        90       100       110
                ....*....|....*....|....*....|....
gi 42565446 152 YASEVVSEEYNALSLSVVSTSRGIGLILGPAIGG 185
Cdd:cd17321 284 AALSSVPKEKAGAASGILNTARQLGGALGVALLG 317

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

78-198

1.84e-03

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.26 E-value: 1.84e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLST-SFWLAISVRFLLGCF-NCLLGVIRAYASE 155
Cdd:cd17365 208 ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPaSLVLLYVLVFLAGACvNGAQVGLYALAAR 287

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 42565446 156 VVSEEYNAlslSVVSTSRGI---GLILGPAIGGYLAQPAEKYPNIF 198
Cdd:cd17365 288 FYPTEVRA---TGVGWALGVgrlGAILGPLLGGLLLAAGLGPESVF 330

PRK11043

Bcr/CflA family multidrug efflux MFS transporter;

71-138

1.90e-03

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 40.65 E-value: 1.90e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42565446   71 EEDIGFYAGFVGSS---FMIGRALTSIFWGKLADRYGRKPIILIG--TFSVIIFNTLFglSTSFWLAISVRFL 138
Cdd:PRK11043  33 QADLQTSASAVSASlslFLAGFALGQLLWGPLSDRYGRKPVLLAGlsLFALGSLGMLW--VESAAQLLVLRFV 103

MFS_SLC22A16_CT2

cd17375

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...

73-231

2.43e-03

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 40.12 E-value: 2.43e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  73 DIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNC-LLGVIRA 151
Cdd:cd17375  32 DREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSgYLVVVFV 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 152 YASEVVSEEYNALSLSVVSTSRGIGLILgPAIGGYLAQpaekypnifsqssvfgrfPYFLPSLVISVYATAVLIACWWLP 231
Cdd:cd17375 112 YVTEFTGIKARTWASMHVHAFFAVGIMV-VALVGYLVR------------------TWWIYQIILSLVTIPFILCCWMLP 172

MFS_GLUT_Class1_2_like

cd17357

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...

79-233

2.46e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 40.32 E-value: 2.46e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  79 GFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLS---TSFWLAISVRFLLG-CFNCLLGVIRAYAS 154
Cdd:cd17357  52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGiACGLSTGFVPMYLQ 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 155 EVVSEEYNALslsvVSTSRGIGLILGPAIGGylaqpaekypnIFSQSSVFG---RFPYFLpsLVISVYATAVLIACWWLP 231
Cdd:cd17357 132 EISPSELRGA----LGSLTQIGVTLGILLGQ-----------VFGLPSVLGtetLWPYLL--FFPGIPALLQLAALPFFP 194


                ..
gi 42565446 232 ET 233
Cdd:cd17357 195 ES 196

MFS_SLC18B1

cd17385

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...

78-219

2.51e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 39.89 E-value: 2.51e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIG---RALTSIFWGKLADRYG-RKPIILIGT-FSVIIF-----NTLFGLSTSFWLAISVRFLLG------- 140
Cdd:cd17385 235 PGQVGLMFLILagsYAISAPLWGWLSDKKKiPKWLMVIGSiITGVGFlllgpAPLLPIKSELWMVIIGLVLLGlslgaal 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 141 --CFNCLLGVIRAYASEVVSEEYNALSlSVVSTSRGIGLILGPAIGGYLaqpAEKYPniFSQSSVFGRFPYFLPSLVISV 218
Cdd:cd17385 315 vpTFPELLNCAREYGFPDNLSTYGLVS-GLFNAAFSLGAFIGPTLGGFL---LERLG--FEWAATIQAGLAFVVGILMSI 388


                .
gi 42565446 219 Y 219
Cdd:cd17385 389 Y 389

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

97-471

3.68e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 39.91 E-value: 3.68e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    97 GKLADRYGRKPIILIG-TFSVII--FNTLFGLSTSFWLAISVRFLLGCFNCLL-----GVIRayasEVVSEEYNALSLSV 168
Cdd:PRK08633   68 GFLADKFSKNRVIRIVkLFEVGLtlLIVLAYYLGWFWLAFAVTFLLGAQSAIYspakyGIIP----ELVGKENLSRANGL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   169 VSTSRGIGLILGPAIGGYLAQpaEKYPnifSQSSVFGRFPYFLPsLVISVYATAVLIACWWLPETLHT--RCRIAQGRLN 246
Cdd:PRK08633  144 LEAFTIVAILAGTALFSFLFE--SVNG---NTPSEILGRIAPAG-LVLLAVAVLGLIFAYRLPKVPAAapEVFDKKKYLF 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   247 PTELNDDESrgggldeqkiinkpSLLRNRPLMAIIIVYCVFslqeiayneifslWAVSD------RSYGGLSFSSQD--- 317
Cdd:PRK08633  218 PKLLWRNLK--------------LLRSDRVLWLAIIGLSYF-------------WFISQlaqanfPAYAKEVLGLDNtfq 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   318 VGEVLAISGLGLlvfqllvypplekSVGLLAVIRLS----AVLLIPLLSCypYIAlLSGVTLHLVINCASIIKNALSISL 393
Cdd:PRK08633  271 VQYLLAASAIGI-------------GIGSLLAGRLSgrhiELGLVPLGAL--GLA-LSLFLLPTAPSLASVLVLFFLFGF 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   394 VTGLFIM-LNKAV----PQNQRG---AANG----ISMTAMSVFksfgpaggGVLFSWAQkrQDATFLpgdemvFLVLNLV 461
Cdd:PRK08633  335 SAGLFIVpLNALIqfraPEKELGkvlAANNflqnVGMLLFLAL--------TTLFSGLG--LSPAGL------FYLIALV 398

                         410
                  ....*....|
gi 42565446   462 QLVGLILTFI 471
Cdd:PRK08633  399 TLIGTLYTLL 408

TRI12

pfam06609

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...

70-234

4.17e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.

Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 39.65 E-value: 4.17e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446    70 QEEDIGFYAgfvgSSFMIGRALTSIFWGKLADRYGRKPII----LIGTFSVII------FNTLFGLSTsfwlaisvrfLL 139
Cdd:pfam06609  76 QSENQGLFS----TLWTMGQAVSILMMGRLTDRFGRRPFViathIIGLVGAIVgctankFNTLLAAMT----------LL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   140 GCFNCLLGVIRAYASEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLaqpaekypnifsqsSVFGRFPYFLPSLVISVY 219
Cdd:pfam06609 142 GVAAGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRL--------------AIQGNWRWIFYIYIIMSA 207

                         170
                  ....*....|....*
gi 42565446   220 ATAVLIACWWLPETL 234
Cdd:pfam06609 208 IAVLLIIIWYHPPSF 222

MFS_GLUT12_Class3

cd17435

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...

81-180

4.39e-03

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 39.40 E-value: 4.39e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  81 VGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGCFNCLLGVIRA-YASEVVSE 159
Cdd:cd17435  41 VVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCvYIAEIAPQ 120

                        90       100
                ....*....|....*....|.
gi 42565446 160 EYNALSLSVVSTSRGIGLILG 180
Cdd:cd17435 121 HRRGLLVSLNELMIVIGILLA 141

PRK09874

multidrug efflux MFS transporter MdtG;

33-184

5.77e-03

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.13 E-value: 5.77e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446   33 PYLHLSfIWLVSLCTALPISSLFPYIYFMIRDfhIAKQEEDIGFYAGFVGSSFMIGRALTSIFWGKLADRYGRKPIILIG 112
Cdd:PRK09874 218 PKLVLS-LFVTTLIIQVATGSIAPILTLYVRE--LAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITA 294

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565446  113 -TFSVIIFNTLFGLSTSFWLAIsVRFLLGCFNCLLgvIRAYASEVVSEEYNALSLSVVS---TSRGIGLILGPAIG 184
Cdd:PRK09874 295 lIFSVLLLIPMSFVQTPLQLGI-LRFLLGAADGAL--LPAVQTLLVYNSSNQIAGRIFSynqSFRDIGNVTGPLMG 367

MFS_Amf1_MDR_like

cd17476

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...

94-191

6.36e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 38.78 E-value: 6.36e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  94 IFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLG-----CFNCLLGVI-RAYaseVVSEEYNaLSLS 167
Cdd:cd17476  51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGlgpafLLPNAMALLgRTY---PPGPRKN-IVFS 126

                        90       100
                ....*....|....*....|....
gi 42565446 168 VVSTSRGIGLILGPAIGGYLAQPA 191
Cdd:cd17476 127 LFGATAPLGFALGGVFGGLFAQLA 150

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

86-189

7.22e-03

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 7.22e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  86 MIGRALTSIFWGKLADRYGR-KPIILIG-TFSVIIFNTLFGLSTSFW-LAISVRFLLGCFNCLLGVIRAYASEVVSEEYN 162
Cdd:cd17472 239 ILIGFILMVPFVIYAEKKGKmKQVFVSSiLLIAVGFLLLLFAATSLWlLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYR 318

                        90       100
                ....*....|....*....|....*..
gi 42565446 163 ALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17472 319 GTAMGIYNTSQFLGSFLGGALGGLLWG 345

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

78-189

7.88e-03

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.32 E-value: 7.88e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  78 AGFVGSSFMIGRALTSIFWGKLADRYG---RKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFL-LGCFNCLLGVIRAYA 153
Cdd:cd17319 217 VGLLAAIPFLAGAIGMILGGRLSDRLLrgaRRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLaGFGIGAASPVFWSLP 296

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 42565446 154 SEVVSEEYNALSLSVVSTSRGIGLILGPAIGGYLAQ 189
Cdd:cd17319 297 ADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVD 332

MFS_SLC22A17_like

cd17373

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...

84-149

8.96e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 38.27 E-value: 8.96e-03

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565446  84 SFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISVRFLLGcfNCLLGVI 149
Cdd:cd17373  33 SLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEG--FCLAGII 96

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

79-233

9.41e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 38.39 E-value: 9.41e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446  79 GFVGSSFMIGRALTSIFWGKLADRYGRKPIILIGTFSVIIFNTLFGLSTSFWLAISV-RFLLGCFnclLGVIRA----YA 153
Cdd:cd17356  48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVgRIIAGLG---VGFASVlvpvYQ 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565446 154 SEVVSEEYNALSLSVVSTSRGIGLILGPAIGgylaqpaekypniFSQSSVFGRFPYFLPSLVISVYATAVLIACWWLPET 233
Cdd:cd17356 125 SEVAPKHIRGTLVSLYQLAITIGILVAYCIN-------------YGTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPES 191

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01