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Conserved domains on  [gi|15229856|ref|NP_189992|]
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F-box/RNI-like superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/FBD/LRR-repeat protein( domain architecture ID 17779756)

F-box/FBD/LRR-repeat protein may be a component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50|3.80.10.10
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  31898225|11178263|10581972|14747988|7583641|11751054
SCOP:  4001927|4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
361-427 5.24e-13

domain in FBox and BRCT domain containing plant proteins;


:

Pssm-ID: 214730  Cd Length: 72  Bit Score: 63.70  E-value: 5.24e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15229856    361 IKVLRIMQYQGSATVLKHISHFLLNMDCLEVMKVNVAAALDDpKKMQLTEDLLKLPTASCKLKIQVL 427
Cdd:smart00579   7 LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDDE-EKLEILKELLSLPRASSSCQVQFL 72
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
 4-36 1.08e-10

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438931  Cd Length: 36  Bit Score: 56.14  E-value: 1.08e-10
                        10        20        30
                ....*....|....*....|....*....|...
gi 15229856   4 LPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFT 36
Cdd:cd22160   4 LPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
 
Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
361-427 5.24e-13

domain in FBox and BRCT domain containing plant proteins;


Pssm-ID: 214730  Cd Length: 72  Bit Score: 63.70  E-value: 5.24e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15229856    361 IKVLRIMQYQGSATVLKHISHFLLNMDCLEVMKVNVAAALDDpKKMQLTEDLLKLPTASCKLKIQVL 427
Cdd:smart00579   7 LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDDE-EKLEILKELLSLPRASSSCQVQFL 72
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
 4-36 1.08e-10

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438931  Cd Length: 36  Bit Score: 56.14  E-value: 1.08e-10
                        10        20        30
                ....*....|....*....|....*....|...
gi 15229856   4 LPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFT 36
Cdd:cd22160   4 LPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 1-41 1.82e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.67  E-value: 1.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15229856     1 MDCLPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFTRSDNL 41
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLW 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
4-44 1.88e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15229856      4 LPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFTRSDNLDFH 44
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
FBD smart00579
domain in FBox and BRCT domain containing plant proteins;
361-427 5.24e-13

domain in FBox and BRCT domain containing plant proteins;


Pssm-ID: 214730  Cd Length: 72  Bit Score: 63.70  E-value: 5.24e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15229856    361 IKVLRIMQYQGSATVLKHISHFLLNMDCLEVMKVNVAAALDDpKKMQLTEDLLKLPTASCKLKIQVL 427
Cdd:smart00579   7 LEVLEIKGYRGTEEEKELVKYFLENAPCLKKLTISVETSDDE-EKLEILKELLSLPRASSSCQVQFL 72
F-box_AtFBL13-like cd22160
F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) ...
 4-36 1.08e-10

F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438931  Cd Length: 36  Bit Score: 56.14  E-value: 1.08e-10
                        10        20        30
                ....*....|....*....|....*....|...
gi 15229856   4 LPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFT 36
Cdd:cd22160   4 LPDELLCHILSFLPTKDAVKTSVLSKRWRHLWR 36
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 1-41 1.82e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.67  E-value: 1.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15229856     1 MDCLPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFTRSDNL 41
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLW 41
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 2-41 7.31e-04

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 37.30  E-value: 7.31e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15229856   2 DCLPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFtRSDNL 41
Cdd:cd22151   1 RKLPDDLLQEIFKRLDPKSLARAACVCRRWRAAA-RSESL 39
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 4-37 1.74e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.90  E-value: 1.74e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15229856   4 LPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFTR 37
Cdd:cd22157   3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISS 36
FBOX smart00256
A Receptor for Ubiquitination Targets;
4-44 1.88e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.88  E-value: 1.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15229856      4 LPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFTRSDNLDFH 44
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 1-34 2.62e-03

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 35.40  E-value: 2.62e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15229856   1 MDCLPDDLLVQILYLLPTKEAVSTSVLSKRWRTL 34
Cdd:cd22123   1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWRRL 34
F-box_AtARP8-like cd22156
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ...
 2-40 2.97e-03

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438927  Cd Length: 45  Bit Score: 35.43  E-value: 2.97e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15229856   2 DCLPDDLLVQILYLLPTKEAVSTSVLSKRWRTLFtrSDN 40
Cdd:cd22156   3 DQLPEDVLMQILRLLGPKDAAKLCLVCKSWRYLV--SDN 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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