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Conserved domains on  [gi|186510672|ref|NP_190039|]
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histone chaperone HIRA-like protein [Arabidopsis thaliana]

Protein Classification

WD40 and Hira domain-containing protein( domain architecture ID 11456814)

WD40 and Hira domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 681-915 2.39e-54

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 188.60  E-value: 2.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   681 GRRAMPTMMMGSAATFIDCDDSWkLLLVTRKGSLYVWDLFNRKCVLHDSLSSLVssdvnLSSTVKvkrmknwylliflvg 760
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSGSY-LLAVTSVGLLYVWDIKKQKALLPPVSLAPL-----LDSSSR--------------- 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   761 dlvvellswyedsSVIDLDCTIKVISVKLSKSGSPLVVLATRHAFLFDTSLMCWLRVADDCFPA-SNFSSSWNL-----G 834
Cdd:pfam07569   60 -------------YSDKLTRAPTITSASLTSNGVPIVTLSNGDGYLYDKSLETWLRISDSWWALgSQYWDSTGSsrsssQ 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   835 SAPCGELAGLQVDVRKYMARK--------PGWNRITDDG------TQTRAHLESQLASSLALESPNEYRQCLLAYVRFLA 900
Cdd:pfam07569  127 SSAAGILSFLERKTNEELLRKgrgrllqrLAKTLLMKEGfenfetVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLA 206

                          250
                   ....*....|....*
gi 186510672   901 READESRLREVCESF 915
Cdd:pfam07569  207 EEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-359 8.73e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 8.73e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672    3 AEKPFWVKHEGlQIFSIDVQPNGERFATGGGDHKVRIWNMKSvdkdlqnidtkERLLATLRDHFGSVNCVRWAKNSRYVA 82
Cdd:COG2319   111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   83 SGSDDQVIQIHerkpgsgttefgsgeapDVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTV 162
Cdd:COG2319   179 SGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  163 LRGHLSLVKGVTWDPIGSFIASQSDDKTVIIWRTSDWGMAHRTDGHWAKslgstfFRRLGWSPCGHFLTTTHGfqkpKHS 242
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------VNSVAFSPDGKLLASGSD----DGT 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  243 APVLERGEWSVAYDFLGHSAPIIVVRFnhsmfkripssthetkqvgwsngtSKSGekdlqsyNVIAMGSQDRTITVWTTG 322
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAF------------------------SPDG-------KTLASGSDDGTVRLWDLA 360

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 186510672  323 SARPLfvaKHFFGQS--VVDLSWSPDGYSLFACSLDGTV 359
Cdd:COG2319   361 TGELL---RTLTGHTgaVTSVAFSPDGRTLASGSADGTV 396
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 681-915 2.39e-54

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 188.60  E-value: 2.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   681 GRRAMPTMMMGSAATFIDCDDSWkLLLVTRKGSLYVWDLFNRKCVLHDSLSSLVssdvnLSSTVKvkrmknwylliflvg 760
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSGSY-LLAVTSVGLLYVWDIKKQKALLPPVSLAPL-----LDSSSR--------------- 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   761 dlvvellswyedsSVIDLDCTIKVISVKLSKSGSPLVVLATRHAFLFDTSLMCWLRVADDCFPA-SNFSSSWNL-----G 834
Cdd:pfam07569   60 -------------YSDKLTRAPTITSASLTSNGVPIVTLSNGDGYLYDKSLETWLRISDSWWALgSQYWDSTGSsrsssQ 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   835 SAPCGELAGLQVDVRKYMARK--------PGWNRITDDG------TQTRAHLESQLASSLALESPNEYRQCLLAYVRFLA 900
Cdd:pfam07569  127 SSAAGILSFLERKTNEELLRKgrgrllqrLAKTLLMKEGfenfetVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLA 206

                          250
                   ....*....|....*
gi 186510672   901 READESRLREVCESF 915
Cdd:pfam07569  207 EEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-359 8.73e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 8.73e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672    3 AEKPFWVKHEGlQIFSIDVQPNGERFATGGGDHKVRIWNMKSvdkdlqnidtkERLLATLRDHFGSVNCVRWAKNSRYVA 82
Cdd:COG2319   111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   83 SGSDDQVIQIHerkpgsgttefgsgeapDVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTV 162
Cdd:COG2319   179 SGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  163 LRGHLSLVKGVTWDPIGSFIASQSDDKTVIIWRTSDWGMAHRTDGHWAKslgstfFRRLGWSPCGHFLTTTHGfqkpKHS 242
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------VNSVAFSPDGKLLASGSD----DGT 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  243 APVLERGEWSVAYDFLGHSAPIIVVRFnhsmfkripssthetkqvgwsngtSKSGekdlqsyNVIAMGSQDRTITVWTTG 322
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAF------------------------SPDG-------KTLASGSDDGTVRLWDLA 360

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 186510672  323 SARPLfvaKHFFGQS--VVDLSWSPDGYSLFACSLDGTV 359
Cdd:COG2319   361 TGELL---RTLTGHTgaVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-359 7.37e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.96  E-value: 7.37e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   11 HEGlQIFSIDVQPNGERFATGGGDHKVRIWNMKSvdkdlqnidtkERLLATLRDHFGSVNCVRWAKNSRYVASGSDDQVI 90
Cdd:cd00200     8 HTG-GVTCVAFSPDGKLLATGSGDGTIKVWDLET-----------GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   91 QIHerkpgsgttefgsgeapDVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLV 170
Cdd:cd00200    76 RLW-----------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  171 KGVTWDPIGSFIASQSDDKTVIIWRTSDWGMAHRTDGHwakslgSTFFRRLGWSPCG-HFLTTTHgfqkpKHSAPVLERG 249
Cdd:cd00200   139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH------TGEVNSVAFSPDGeKLLSSSS-----DGTIKLWDLS 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  250 EWSVAYDFLGHSAPIIVVRFNHSmfkripssthetkqvgwsngtsksgekdlqSYNVIAmGSQDRTITVWTTGSARPLFV 329
Cdd:cd00200   208 TGKCLGTLRGHENGVNSVAFSPD------------------------------GYLLAS-GSEDGTIRVWDLRTGECVQT 256

                         330       340       350
                  ....*....|....*....|....*....|
gi 186510672  330 AKHFFGqSVVDLSWSPDGYSLFACSLDGTV 359
Cdd:cd00200   257 LSGHTN-SVTSLAWSPDGKRLASGSADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-153 1.03e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.03e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 186510672    114 NWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWN 153
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
115-153 1.20e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 1.20e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 186510672   115 WKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWN 153
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 118-194 3.87e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.19  E-value: 3.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  118 VMTLRGHTADVVDLNWSPDDS-MLASGSLDNTVHIWNMRTG----------MCttVLRGHLSLVKGVTWDPIGSFIASQS 186
Cdd:PTZ00420   67 VIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNdesvkeikdpQC--ILKGHKKKISIIDWNPMNYYIMCSS 144


                  ....*....
gi 186510672  187 D-DKTVIIW 194
Cdd:PTZ00420  145 GfDSFVNIW 153
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 681-915 2.39e-54

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 188.60  E-value: 2.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   681 GRRAMPTMMMGSAATFIDCDDSWkLLLVTRKGSLYVWDLFNRKCVLHDSLSSLVssdvnLSSTVKvkrmknwylliflvg 760
Cdd:pfam07569    1 GRRLLPPIVLGSPASFLECSGSY-LLAVTSVGLLYVWDIKKQKALLPPVSLAPL-----LDSSSR--------------- 59

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   761 dlvvellswyedsSVIDLDCTIKVISVKLSKSGSPLVVLATRHAFLFDTSLMCWLRVADDCFPA-SNFSSSWNL-----G 834
Cdd:pfam07569   60 -------------YSDKLTRAPTITSASLTSNGVPIVTLSNGDGYLYDKSLETWLRISDSWWALgSQYWDSTGSsrsssQ 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   835 SAPCGELAGLQVDVRKYMARK--------PGWNRITDDG------TQTRAHLESQLASSLALESPNEYRQCLLAYVRFLA 900
Cdd:pfam07569  127 SSAAGILSFLERKTNEELLRKgrgrllqrLAKTLLMKEGfenfetVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLA 206

                          250
                   ....*....|....*
gi 186510672   901 READESRLREVCESF 915
Cdd:pfam07569  207 EEGLKGRLRELCKEL 221
WD40 COG2319
WD40 repeat [General function prediction only];
3-359 8.73e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 8.73e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672    3 AEKPFWVKHEGlQIFSIDVQPNGERFATGGGDHKVRIWNMKSvdkdlqnidtkERLLATLRDHFGSVNCVRWAKNSRYVA 82
Cdd:COG2319   111 LLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLAT-----------GKLLRTLTGHSGAVTSVAFSPDGKLLA 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   83 SGSDDQVIQIHerkpgsgttefgsgeapDVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTV 162
Cdd:COG2319   179 SGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  163 LRGHLSLVKGVTWDPIGSFIASQSDDKTVIIWRTSDWGMAHRTDGHWAKslgstfFRRLGWSPCGHFLTTTHGfqkpKHS 242
Cdd:COG2319   242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------VNSVAFSPDGKLLASGSD----DGT 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  243 APVLERGEWSVAYDFLGHSAPIIVVRFnhsmfkripssthetkqvgwsngtSKSGekdlqsyNVIAMGSQDRTITVWTTG 322
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAF------------------------SPDG-------KTLASGSDDGTVRLWDLA 360

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 186510672  323 SARPLfvaKHFFGQS--VVDLSWSPDGYSLFACSLDGTV 359
Cdd:COG2319   361 TGELL---RTLTGHTgaVTSVAFSPDGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-359 7.37e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.96  E-value: 7.37e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   11 HEGlQIFSIDVQPNGERFATGGGDHKVRIWNMKSvdkdlqnidtkERLLATLRDHFGSVNCVRWAKNSRYVASGSDDQVI 90
Cdd:cd00200     8 HTG-GVTCVAFSPDGKLLATGSGDGTIKVWDLET-----------GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   91 QIHerkpgsgttefgsgeapDVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLV 170
Cdd:cd00200    76 RLW-----------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  171 KGVTWDPIGSFIASQSDDKTVIIWRTSDWGMAHRTDGHwakslgSTFFRRLGWSPCG-HFLTTTHgfqkpKHSAPVLERG 249
Cdd:cd00200   139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH------TGEVNSVAFSPDGeKLLSSSS-----DGTIKLWDLS 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  250 EWSVAYDFLGHSAPIIVVRFNHSmfkripssthetkqvgwsngtsksgekdlqSYNVIAmGSQDRTITVWTTGSARPLFV 329
Cdd:cd00200   208 TGKCLGTLRGHENGVNSVAFSPD------------------------------GYLLAS-GSEDGTIRVWDLRTGECVQT 256

                         330       340       350
                  ....*....|....*....|....*....|
gi 186510672  330 AKHFFGqSVVDLSWSPDGYSLFACSLDGTV 359
Cdd:cd00200   257 LSGHTN-SVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
15-374 1.97e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 1.97e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   15 QIFSIDVQPNGERFATGGGDHKVRIWNMKSvdkdlqnidtkERLLATLRDHFGSVNCVRWAKNSRYVASGSDDQVIQIHe 94
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLAT-----------GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   95 rkpgsgttefgsgeapDVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLVKGVT 174
Cdd:COG2319   148 ----------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  175 WDPIGSFIASQSDDKTVIIWRTSDWGMAHRTDGHwakslgSTFFRRLGWSPCGHFLTTTHGFQKPKhsapVLERGEWSVA 254
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH------SGSVRSVAFSPDGRLLASGSADGTVR----LWDLATGELL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  255 YDFLGHSAPIIVVRFnhsmfkripssthetkqvgwsngtSKSGekdlqsyNVIAMGSQDRTITVWTTGSARPLFVAKHFF 334
Cdd:COG2319   282 RTLTGHSGGVNSVAF------------------------SPDG-------KLLASGSDDGTVRLWDLATGKLLRTLTGHT 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 186510672  335 GqSVVDLSWSPDGYSLFACSLDGTVAMIHFDPKELGVRLT 374
Cdd:COG2319   331 G-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
10-198 2.37e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 2.37e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   10 KHEGLQIFSIDVQPNGERFATGGGDHKVRIWNMKSvdkdlqnidtkERLLATLRDHFGSVNCVRWAKNSRYVASGSDDQV 89
Cdd:COG2319   243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-----------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   90 IQIherkpgsgttefgsgeaPDVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSL 169
Cdd:COG2319   312 VRL-----------------WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                         170       180
                  ....*....|....*....|....*....
gi 186510672  170 VKGVTWDPIGSFIASQSDDKTVIIWRTSD 198
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-195 5.71e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 5.71e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   11 HEGlQIFSIDVQPNGERFATGGGDHKVRIWNMksvdkdlqnidTKERLLATLRDHFGSVNCVRWAKNSRYVASGSDDQVI 90
Cdd:cd00200    92 HTS-YVSSVAFSPDGRILSSSSRDKTIKVWDV-----------ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   91 QIHERKPGSGTTEFGSGEAP-------------------------DVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSL 145
Cdd:cd00200   160 KLWDLRTGKCVATLTGHTGEvnsvafspdgekllssssdgtiklwDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 186510672  146 DNTVHIWNMRTGMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKTVIIWR 195
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 120-359 1.28e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  120 TLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKTVIIWRTSDW 199
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  200 GMAHRTDGHwAKSLGStffrrLGWSPCGHFLTTThGFQKpkhSAPVlergeWSVA-----YDFLGHSAPIIVVRFNhsmf 274
Cdd:cd00200    84 ECVRTLTGH-TSYVSS-----VAFSPDGRILSSS-SRDK---TIKV-----WDVEtgkclTTLRGHTDWVNSVAFS---- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  275 kriPSSThetkqvgwsngtsksgekdlqsynVIAMGSQDRTITVWTTGSARPLFVAKHFFGqSVVDLSWSPDGYSLFACS 354
Cdd:cd00200   145 ---PDGT------------------------FVASSSQDGTIKLWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSS 196


                  ....*
gi 186510672  355 LDGTV 359
Cdd:cd00200   197 SDGTI 201
WD40 COG2319
WD40 repeat [General function prediction only];
111-359 4.54e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 4.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  111 DVENWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKT 190
Cdd:COG2319    64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  191 VIIWRTSDwgmahrtdghwakslgstffrrlgwspcGHFLTTTHGfqkpkHSAPVlergeWSVAYdflghsapiivvrfn 270
Cdd:COG2319   144 VRLWDLAT----------------------------GKLLRTLTG-----HSGAV-----TSVAF--------------- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  271 hsmfkripssthetkqvgwsngtSKSGEkdlqsynVIAMGSQDRTITVWTTGSARPLFVAK-HffGQSVVDLSWSPDGYS 349
Cdd:COG2319   171 -----------------------SPDGK-------LLASGSDDGTVRLWDLATGKLLRTLTgH--TGAVRSVAFSPDGKL 218

                         250
                  ....*....|
gi 186510672  350 LFACSLDGTV 359
Cdd:COG2319   219 LASGSADGTV 228
WD40 COG2319
WD40 repeat [General function prediction only];
120-374 1.61e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  120 TLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKTVIIWRTSDW 199
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  200 GMAHRTDGHwakslgSTFFRRLGWSPCGHFLTTTHGfqkpKHSAPVLERGEWSVAYDFLGHSAPIIVVRFNH-------- 271
Cdd:COG2319   111 LLLRTLTGH------TGAVRSVAFSPDGKTLASGSA----DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdgkllasg 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  272 --------------SMFKRIPSSTHETKQVGWS-NGtsksgekdlqsyNVIAMGSQDRTITVWTTGSARPLFVAKHfFGQ 336
Cdd:COG2319   181 sddgtvrlwdlatgKLLRTLTGHTGAVRSVAFSpDG------------KLLASGSADGTVRLWDLATGKLLRTLTG-HSG 247

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 186510672  337 SVVDLSWSPDGYSLFACSLDGTVAMIHFDPKELGVRLT 374
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-153 1.03e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.03e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 186510672    114 NWKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWN 153
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
115-153 1.20e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 1.20e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 186510672   115 WKAVMTLRGHTADVVDLNWSPDDSMLASGSLDNTVHIWN 153
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 118-194 3.87e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.19  E-value: 3.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672  118 VMTLRGHTADVVDLNWSPDDS-MLASGSLDNTVHIWNMRTG----------MCttVLRGHLSLVKGVTWDPIGSFIASQS 186
Cdd:PTZ00420   67 VIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNdesvkeikdpQC--ILKGHKKKISIIDWNPMNYYIMCSS 144


                  ....*....
gi 186510672  187 D-DKTVIIW 194
Cdd:PTZ00420  145 GfDSFVNIW 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 156-194 2.83e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.83e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 186510672    156 TGMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKTVIIW 194
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-94 1.90e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.90e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 186510672     57 RLLATLRDHFGSVNCVRWAKNSRYVASGSDDQVIQIHE 94
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 121-193 5.82e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 5.82e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186510672  121 LRGHTADVVDLNWSPD-DSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKTVII 193
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
157-194 6.45e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 6.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 186510672   157 GMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKTVIIW 194
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
57-92 6.71e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 6.71e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 186510672    57 RLLATLRDHFGSVNCVRWAKNSRYVASGSDDQVIQI 92
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 24-158 9.57e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510672   24 NGERFATGGGDHKVRIWNMKSVDKDLQNIDTKERLLATlRDHFGSVNCVRWAKNSryVASGSDDQVIQIHerkpgsgtte 103
Cdd:PLN00181  494 DGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELAS-RSKLSGICWNSYIKSQ--VASSNFEGVVQVW---------- 560

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 186510672  104 fgsgeapDVENWKAVMTLRGHTADVVDLNWSP-DDSMLASGSLDNTVHIWNMRTGM 158
Cdd:PLN00181  561 -------DVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGV 609
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-41 1.91e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.91e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 186510672     11 HEGlQIFSIDVQPNGERFATGGGDHKVRIWN 41
Cdd:smart00320   11 HTG-PVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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