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Conserved domains on  [gi|15229043|ref|NP_190457|]
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RNI-like superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_ScDIA2-like cd22142
F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and ...
 12-59 3.47e-16

F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and similar proteins; ScDIA2 is a replication origin-binding protein that plays a role in regulating DNA replication. It is a component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438914  Cd Length: 48  Bit Score: 71.35  E-value: 3.47e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15229043  12 RWEELDTDILVRIFQKFSVFELTSgLAHVCRGWRAACCD-PILWKTVDL 59
Cdd:cd22142   1 RWENLPLDILPLIFQKFSTKELIT-LSHVCSSWRAKILDfPHLWKTVEL 48
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 91-250 1.05e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 42.70  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229043  91 LSMNLSGGSTRTLIFHFNLFLSDDQLTYTAERCPGLRRVVLPAWNRIKKTGICKAIRIWKDLESLTMPSIANPPYL---- 166
Cdd:cd09293  45 LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRNGHLItdvs 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229043 167 LTEIAKNCKNFKelkimgpfEVFFANTLIT----------CLPNIKTLSI-RCSAIKREALMKIL--DGLPSLEVLNI-- 231
Cdd:cd09293 125 LSALGKNCTFLQ--------TVGFAGCDVTdkgvwelasgCSKSLERLSLnNCRNLTDQSIPAILasNYFPNLSVLEFrg 196

                       170       180
                ....*....|....*....|....
gi 15229043 232 -----SHSHLVEYSGWQPQQKVIV 250
Cdd:cd09293 197 cplitDFSRIILFKLWQPRLNKPI 220
 
Name Accession Description Interval E-value
F-box_ScDIA2-like cd22142
F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and ...
 12-59 3.47e-16

F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and similar proteins; ScDIA2 is a replication origin-binding protein that plays a role in regulating DNA replication. It is a component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438914  Cd Length: 48  Bit Score: 71.35  E-value: 3.47e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15229043  12 RWEELDTDILVRIFQKFSVFELTSgLAHVCRGWRAACCD-PILWKTVDL 59
Cdd:cd22142   1 RWENLPLDILPLIFQKFSTKELIT-LSHVCSSWRAKILDfPHLWKTVEL 48
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 13-58 3.75e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 45.94  E-value: 3.75e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15229043    13 WEELDTDILVRIFQKFSVFELTSgLAHVCRGWRAACCDPILWKTVD 58
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLR-LALVCRRWRELASDDSLWRRLC 45
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 91-250 1.05e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 42.70  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229043  91 LSMNLSGGSTRTLIFHFNLFLSDDQLTYTAERCPGLRRVVLPAWNRIKKTGICKAIRIWKDLESLTMPSIANPPYL---- 166
Cdd:cd09293  45 LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRNGHLItdvs 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229043 167 LTEIAKNCKNFKelkimgpfEVFFANTLIT----------CLPNIKTLSI-RCSAIKREALMKIL--DGLPSLEVLNI-- 231
Cdd:cd09293 125 LSALGKNCTFLQ--------TVGFAGCDVTdkgvwelasgCSKSLERLSLnNCRNLTDQSIPAILasNYFPNLSVLEFrg 196

                       170       180
                ....*....|....*....|....
gi 15229043 232 -----SHSHLVEYSGWQPQQKVIV 250
Cdd:cd09293 197 cplitDFSRIILFKLWQPRLNKPI 220
 
Name Accession Description Interval E-value
F-box_ScDIA2-like cd22142
F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and ...
 12-59 3.47e-16

F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and similar proteins; ScDIA2 is a replication origin-binding protein that plays a role in regulating DNA replication. It is a component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438914  Cd Length: 48  Bit Score: 71.35  E-value: 3.47e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15229043  12 RWEELDTDILVRIFQKFSVFELTSgLAHVCRGWRAACCD-PILWKTVDL 59
Cdd:cd22142   1 RWENLPLDILPLIFQKFSTKELIT-LSHVCSSWRAKILDfPHLWKTVEL 48
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 13-58 1.43e-07

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 47.21  E-value: 1.43e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15229043  13 WEELDTDILVRIFQKFSVFELTSGLAHVCRGWRAACCDPILWKTVD 58
Cdd:cd22164   2 WLDLPDDLTASILSRLGAIDILTNAQKVCKLWRRICKDPSMWRVID 47
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 13-58 3.75e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 45.94  E-value: 3.75e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15229043    13 WEELDTDILVRIFQKFSVFELTSgLAHVCRGWRAACCDPILWKTVD 58
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLR-LALVCRRWRELASDDSLWRRLC 45
F-box_FBXL16 cd22127
F-box domain found in F-box/LRR-repeat protein 16 (FBXL16) and similar proteins; FBXL16, also ...
 16-56 2.62e-05

F-box domain found in F-box/LRR-repeat protein 16 (FBXL16) and similar proteins; FBXL16, also called F-box and leucine-rich repeat protein 16, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a repressor of one of the earliest steps in the cardiogenic lineage: FLK1+ progenitor formation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438899  Cd Length: 42  Bit Score: 40.76  E-value: 2.62e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 15229043  16 LDTDILVRIFQKFSVFElTSGLAHVCRGWRAACCDPILWKT 56
Cdd:cd22127   3 LDEKFLNRLFWYFSPCE-RCVLAQVCKKWRDVLYQPKFWRG 42
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
 13-55 2.80e-05

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438891  Cd Length: 47  Bit Score: 40.70  E-value: 2.80e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 15229043  13 WEELDTDILVRIFQkFSVFE-----LTSGLAHVCRGWRAACCDPILWK 55
Cdd:cd22119   1 GQRLPPEILVKIFQ-FAVATegavpLLCRLSRVCRLWREVALDPSLWT 47
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 91-250 1.05e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 42.70  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229043  91 LSMNLSGGSTRTLIFHFNLFLSDDQLTYTAERCPGLRRVVLPAWNRIKKTGICKAIRIWKDLESLTMPSIANPPYL---- 166
Cdd:cd09293  45 LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRHRNGHLItdvs 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229043 167 LTEIAKNCKNFKelkimgpfEVFFANTLIT----------CLPNIKTLSI-RCSAIKREALMKIL--DGLPSLEVLNI-- 231
Cdd:cd09293 125 LSALGKNCTFLQ--------TVGFAGCDVTdkgvwelasgCSKSLERLSLnNCRNLTDQSIPAILasNYFPNLSVLEFrg 196

                       170       180
                ....*....|....*....|....
gi 15229043 232 -----SHSHLVEYSGWQPQQKVIV 250
Cdd:cd09293 197 cplitDFSRIILFKLWQPRLNKPI 220
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
 15-60 7.33e-04

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 37.01  E-value: 7.33e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15229043  15 ELDTDILVRIFQKFSVFELTSGLAHVCRGWRAACCDPILWKTVDLS 60
Cdd:cd22092   4 QLPDSILLKIFSYLSLQERCLSASLVCKYWRDLCLDSQFWKQIDLS 49
F-box_AtSKIP5-like cd22163
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ...
 15-58 1.97e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438934  Cd Length: 46  Bit Score: 35.40  E-value: 1.97e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15229043  15 ELDTDILVRIFQKFSVFELTSGLAHVCRGWRAACCDPILWKTVD 58
Cdd:cd22163   3 DLDDDCLMHIFSFLTPLPDRFNAARVCKRWRALALDPRSWLRVK 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 13-56 3.18e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.82  E-value: 3.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15229043    13 WEELDTDILVRIFQKFSVFELTSgLAHVCRGWRAACCDPILWKT 56
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLR-LSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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