|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
1-464 |
0e+00 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 1000.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 1 MTSSLSLHSSFVPSFADLSDRGLISKNSPTSVSISKVPTWEKKQISNRNSFKLNCVMEKSVDGQTHSTVNNTTDSLNTMN 80
Cdd:PLN02509 1 MTSSLSLHSSFVPSFADLSDRGLVSKNSPTSVSISKVPTWEKKQISNRNSFKLNCVMEKSVDVSTSAVVDGVADCLNEMN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 81 IKEEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
Cdd:PLN02509 81 IKEEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 161 LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIS 240
Cdd:PLN02509 161 LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 241 EMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWL 320
Cdd:PLN02509 241 EMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 321 CLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYF 400
Cdd:PLN02509 321 CLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYF 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15230203 401 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKTFPL 464
Cdd:PLN02509 401 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFRTGPL 464
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
87-464 |
0e+00 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 704.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 87 VSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH 166
Cdd:TIGR01329 1 LSTLLVNTDNKNDPYDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 167 LIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQ 246
Cdd:TIGR01329 81 LLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 247 GALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIK 326
Cdd:TIGR01329 161 NALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 327 TMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSF 406
Cdd:TIGR01329 241 TLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFETGSVALSKRLVEATKLFSITVSF 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15230203 407 GSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKTFPL 464
Cdd:TIGR01329 321 GSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTAPA 378
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
88-460 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 577.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 88 STLLVNLDNKFDP-FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVT 165
Cdd:pfam01053 1 DTLAVHAGQRPDPqTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAItAAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 166 HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA 245
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 246 QGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGI 325
Cdd:pfam01053 161 HGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 326 KTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVAL-SKHLVETTKYFSIAV 404
Cdd:pfam01053 241 KTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEaAKKFLDNLKLFSLAV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15230203 405 SFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:pfam01053 321 SLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
102-460 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 519.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 102 DAMSTPLYQTATFKQPS--------AIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGE 172
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSpaeaadlfALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVlLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 173 EIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLV 252
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 253 DNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRI 332
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 333 EKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKS 411
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFeLKGGLEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 15230203 412 LISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
88-460 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 516.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 88 STLLVNLDNKFDP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGM 158
Cdd:COG0626 4 ATRAVHAGRDPDPqTGAVSPPIYLTSTFVFPSAealaarfaGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 159 AALSAV-THLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIR 237
Cdd:COG0626 84 AAISAVlLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVDIA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 238 KISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFD 317
Cdd:COG0626 164 AIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPFD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 318 CWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVET 396
Cdd:COG0626 244 AWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFeLKGGREAARRFLDA 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15230203 397 TKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:COG0626 324 LKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
103-460 |
3.24e-147 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 424.91 E-value: 3.24e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
Cdd:PRK07671 20 AVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMMLFSSGDHVILTDDVYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 183 GSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 262
Cdd:PRK07671 100 GTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNTFMTPYWQ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 263 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 342
Cdd:PRK07671 180 SPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 343 AMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHA 422
Cdd:PRK07671 260 AEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDVGSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHA 339
|
330 340 350
....*....|....*....|....*....|....*...
gi 15230203 423 SIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK07671 340 SIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
83-460 |
4.07e-146 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 422.64 E-value: 4.07e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 83 EEASVSTLLVNLDNKFDP-FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL 161
Cdd:PRK08064 3 MSYSIDTLLLHNQYKHDKqTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 162 SAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISE 241
Cdd:PRK08064 83 STAFLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 242 MAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLC 321
Cdd:PRK08064 163 LAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 322 LRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFS 401
Cdd:PRK08064 243 LRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQSEEAVRQFVSHVKLPV 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15230203 402 IAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK08064 323 FAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
88-459 |
7.84e-142 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 411.73 E-value: 7.84e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 88 STLLVNLDNKFDPFD-AMSTPLYQTATFKQ--PSAIENGpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SA 163
Cdd:PRK07811 14 ATRAIHAGYEPDPATgAVNPPIYASSTFAQdgVGGLRGG-YEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATdCL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 164 VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMA 243
Cdd:PRK07811 93 LRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 244 HAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLR 323
Cdd:PRK07811 173 HDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 324 GIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSI 402
Cdd:PRK07811 253 GLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVrLAGGEEAARDFCARTKVFTL 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 403 AVSFGSVKSLISMPCFMSHASI---PAEVrearglTEDLVRISAGIEDVDDLISDLDIAF 459
Cdd:PRK07811 333 AESLGGVESLIEHPSAMTHASTagsQLEV------PDDLVRLSVGIEDVADLLADLEQAL 386
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
103-459 |
5.17e-126 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 371.15 E-value: 5.17e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
Cdd:PRK06176 20 AVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLFQSGDHVLLGDDVYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 183 GSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 262
Cdd:PRK06176 100 GTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 263 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 342
Cdd:PRK06176 180 NPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 343 AMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHA 422
Cdd:PRK06176 260 AEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILGESLGGVESLVGIPAFMTHA 339
|
330 340 350
....*....|....*....|....*....|....*..
gi 15230203 423 SIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
Cdd:PRK06176 340 CIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 376
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
86-460 |
4.53e-120 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 355.16 E-value: 4.53e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 86 SVSTLLVNLDNKFDPFD-AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV 164
Cdd:PRK08247 4 TIETKLAQIGNRSDERTgTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 165 THLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAH 244
Cdd:PRK08247 84 MSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 245 AQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRG 324
Cdd:PRK08247 164 KHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 325 IKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAglpdhpghhlhfsqakGAGSVFSFITGSVALSKHLVETTKYFSIAV 404
Cdd:PRK08247 244 MKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP----------------GRGGMLSFRLQDEEWVNPFLKSLKLITFAE 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15230203 405 SFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK08247 308 SLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFK 363
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
101-459 |
5.47e-118 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 350.64 E-value: 5.47e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 101 FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDD 179
Cdd:TIGR02080 19 YGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVtTALLGPDDLLVAPHD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 180 VYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSP 259
Cdd:TIGR02080 99 CYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVGAVVVVDNTFLSP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 260 VLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENA 339
Cdd:TIGR02080 179 ALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 340 RKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCF 418
Cdd:TIGR02080 259 QAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFeLKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPAT 338
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15230203 419 MSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
Cdd:TIGR02080 339 MTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGL 379
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
99-458 |
5.56e-110 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 330.31 E-value: 5.56e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 99 DPFDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIK 169
Cdd:TIGR01328 17 DQFGALTPPIYQTSTFVFDSCEQGGNrfagqesgYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGMGAIAAtLLTILK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 170 NGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGAL 249
Cdd:TIGR01328 97 AGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDMERVCRDAHSQGVK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 250 VLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAK-EVYFLQNSEGSGLAPFDCWLCLRGIKTM 328
Cdd:TIGR01328 177 VIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGSVISPFDAWLILRGLKTL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 329 ALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFG 407
Cdd:TIGR01328 257 NIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFeLKGGFAGAKKLLNNLKLIRLAVSLG 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15230203 408 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIA 458
Cdd:TIGR01328 337 DAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQA 387
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
101-461 |
7.74e-110 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 330.25 E-value: 7.74e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 101 FDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLIKNG 171
Cdd:PRK06234 24 FGSLATPIYQTSTFIFDSAEQGGRrfageesgYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAIsSSLWSALKAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA--QGAL 249
Cdd:PRK06234 104 DHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIKAISNIAHEnnKECL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 250 VLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvLAVKGEKLAKEVYF--LQNSEGSGLAPFDCWLCLRGIKT 327
Cdd:PRK06234 184 VFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAG-FVVGKEEFINQVKLfgIKDMTGSVIGPFEAFLIIRGMKT 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 328 MALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSF 406
Cdd:PRK06234 263 LQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFeLKGGVEEGKVVMNNVKLATLAVSL 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15230203 407 GSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKT 461
Cdd:PRK06234 343 GDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALDL 397
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
99-460 |
1.64e-109 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 330.45 E-value: 1.64e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 99 DP-FDAMSTPLYQTATFKQPSA---------IENGpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 167
Cdd:COG2873 20 DPtTGARAVPIYQTTSYVFDDAehaadlfalKEPG-NIYTRIMNPTTDVLEKRIAALEGGVAALATASGQAAITlAILNL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 168 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG 247
Cdd:COG2873 99 AEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDVLDIEAIAEIAHEHG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 248 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVL--------------------------AVKGEKLAKE 301
Cdd:COG2873 179 VPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwaangkfpeltepdpsyhgLVYTEAFGNA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 302 VY------FLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLhfsqA-- 373
Cdd:COG2873 259 AFitkarvQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPSHPYHEL----Aqk 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 374 ---KGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVD 449
Cdd:COG2873 335 ylpKGAGGVLTFgLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLIRLSVGIEDID 414
|
410
....*....|.
gi 15230203 450 DLISDLDIAFK 460
Cdd:COG2873 415 DIIADLDQALA 425
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
109-459 |
3.96e-109 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 328.62 E-value: 3.96e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 109 YQTATFKQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRL 187
Cdd:PRK08249 46 YDVALGKKPGHI------YSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYtFLKPGDRVVSIKDTYGGTNKI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 188 LSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLEL 267
Cdd:PRK08249 120 FTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLAL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 268 GADIVMHSATKFIAGHSDVMAGVlAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLS 347
Cdd:PRK08249 200 GADLVIHSATKFLSGHADALGGV-VCGSKELMEQVYHYREINGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQ 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 348 SHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPA 426
Cdd:PRK08249 279 THPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFvLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTL 358
|
330 340 350
....*....|....*....|....*....|...
gi 15230203 427 EVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
Cdd:PRK08249 359 EERAALGIPEGLVRISVGIEDTEDLIADLEQAF 391
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
83-456 |
1.35e-107 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 324.26 E-value: 1.35e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 83 EEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCF 154
Cdd:PRK08133 3 DSLGFDTLAVRAGQLRSPFGEHSEALFLTSSFVFESAAEAAArfageepgNIYSRFTNPTVTMFQERLAALEGAEACVAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 155 TSGMAA-LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQI 233
Cdd:PRK08133 83 ASGMAAiLAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 234 SDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEkLAKEVYFLQNSEGSGL 313
Cdd:PRK08133 163 ADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKE-LMEEVFGFLRTAGPTL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 314 APFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKH 392
Cdd:PRK08133 242 SPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFeVKGGREAAWR 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15230203 393 LVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLD 456
Cdd:PRK08133 322 VIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLA 385
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
89-458 |
2.98e-106 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 320.64 E-value: 2.98e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 89 TLLVNLDNKFDPFDAMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
Cdd:TIGR01325 2 TLAVRGGMLRSGFEETAEALYLTSGYVYDSAAvaakrfagELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 161 -LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKI 239
Cdd:TIGR01325 82 iFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 240 SEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCW 319
Cdd:TIGR01325 162 AELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAW 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 320 LCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKY 399
Cdd:TIGR01325 242 VLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCRQAAFKVLDAMRL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 15230203 400 FSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIA 458
Cdd:TIGR01325 322 VDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRA 380
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
99-460 |
2.77e-103 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 313.15 E-value: 2.77e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 99 DPFDAMSTPLYQTATFKQPsaIENGPYD------YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNG 171
Cdd:PRK08574 15 DPYGSLQPPIYLTALFRQE--GEAYPSDrgfdlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLfFSLLKAG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 172 EEIVAGDDVYGGSDRLLSQVVpRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 251
Cdd:PRK08574 93 DRVVLPMEAYGTTLRLLKSLE-KFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 331
Cdd:PRK08574 172 VDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 332 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLH---FSQAKgAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFG 407
Cdd:PRK08574 252 FERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAkrlFGKDL-YGGVVSFrVKGGRDAVLKFLRSLKLIKPSPSLG 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 15230203 408 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK08574 331 GVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALG 383
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
103-458 |
4.15e-101 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 306.75 E-value: 4.15e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
Cdd:PRK07269 24 ALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLAFSVFPVGSKVVAVRDLYG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 183 GSDRLLSQVVPRSGVVVKRVNTTKldEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 262
Cdd:PRK07269 104 GSFRWFNQQEKEGRFHFTYANTEE--ELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 263 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 342
Cdd:PRK07269 182 RPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 343 AMYLSSHPRVKKVYYAGLpdhpghhlhfsqakgaGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHA 422
Cdd:PRK07269 262 VAFLKKSPAVKEVLYTGK----------------GGMISFKVADETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHA 325
|
330 340 350
....*....|....*....|....*....|....*.
gi 15230203 423 SIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIA 458
Cdd:PRK07269 326 DIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQA 361
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
107-460 |
1.16e-100 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 306.44 E-value: 1.16e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 107 PLYQTAT-----FKQPSAiengpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDDV 180
Cdd:PRK08045 26 PIHLSSTynftgFNEPRA-----HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVtTVFLKPGDLLVAPHDC 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 181 YGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPV 260
Cdd:PRK08045 101 YGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 261 LSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENAR 340
Cdd:PRK08045 181 LQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 341 KIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFM 419
Cdd:PRK08045 261 AIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFeLDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATM 340
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15230203 420 SHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK08045 341 THAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
103-455 |
2.09e-100 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 306.53 E-value: 2.09e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVY 181
Cdd:PRK08776 30 AVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNaLLQPGDTLVVPHDAY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 182 GGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVL 261
Cdd:PRK08776 110 GGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPAL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 262 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 341
Cdd:PRK08776 190 QKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 342 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 420
Cdd:PRK08776 270 IAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFeLEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMT 349
|
330 340 350
....*....|....*....|....*....|....*
gi 15230203 421 HASIPAEVREARGLTEDLVRISAGIEDVDDLISDL 455
Cdd:PRK08776 350 HAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDL 384
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
98-460 |
8.33e-99 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 302.11 E-value: 8.33e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 98 FDPFD---AMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT- 165
Cdd:PRK07503 19 YDPLDhggALVPPVYLTATFAFPTAEygaecfagEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATLw 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 166 HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA 245
Cdd:PRK07503 99 TLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 246 QGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvLAVKGEKLAKEV--YFLQNSEGSGLAPFDCWLCLR 323
Cdd:PRK07503 179 AGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAG-LVVGGKALADRIrlEGLKDMTGAVMSPFDAFLLMR 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 324 GIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSI 402
Cdd:PRK07503 258 GLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFeLKGGIAAGRRFMNALQLFAR 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 15230203 403 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK07503 338 AVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
101-460 |
2.70e-96 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 295.21 E-value: 2.70e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 101 FDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNG 171
Cdd:PRK06767 21 KGSLTPPLFQTSTFTFETAQQGEAsfagvdpsYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMAAISATlIGFLKAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 251
Cdd:PRK06767 101 DHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQVIRVAKRNGLLVI 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 331
Cdd:PRK06767 181 VDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 332 IEKQQENARKIAMYLSSHPRVKKVYYaglpdhPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVK 410
Cdd:PRK06767 261 MDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFsIKGGKEETQAFINDLHFITIAVSLGDTE 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 15230203 411 SLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK06767 335 TLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
101-459 |
3.33e-96 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 294.88 E-value: 3.33e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 101 FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIKNGEEIVAGDD 179
Cdd:PRK08861 21 YHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLwVSALLGPDDLIVAPHD 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 180 VYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSP 259
Cdd:PRK08861 101 CYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 260 VLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENA 339
Cdd:PRK08861 181 VLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVHEESA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 340 RKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCF 418
Cdd:PRK08861 261 QQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFeFAGSFEQLKVFVKALALFSLAESLGGVESLICHPAS 340
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15230203 419 MSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
Cdd:PRK08861 341 MTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAF 381
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
103-460 |
1.06e-93 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 289.64 E-value: 1.06e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEE 173
Cdd:TIGR01326 19 SRAVPIYQTTSYVFDSTehaaalfgLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVASGQAAITyAILNLAGAGDN 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 174 IVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVD 253
Cdd:TIGR01326 99 IVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDIEAIAEVAHRHGIPLIVD 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 254 NSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLaVKGEKL--AKEVY--FLQNSE-------------------- 309
Cdd:TIGR01326 179 NTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVI-VDGGKFdwNNGRFplFTTPDPsyhglvftetlgnpafilka 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 310 --------GSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL---HFSqaKGAGS 378
Cdd:TIGR01326 258 rvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPHHALakkYLP--KGFGA 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 379 VFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDI 457
Cdd:TIGR01326 336 VLSFeIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLSVGIENIDDIIADLEQ 415
|
...
gi 15230203 458 AFK 460
Cdd:TIGR01326 416 ALE 418
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
98-458 |
1.72e-87 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 271.87 E-value: 1.72e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 98 FDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDkADRAFCFTSGMAALSAVTH-LIKNGEEIVA 176
Cdd:PRK07582 16 AVPGEPVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELE-GAEALVFPSGMAAITAVLRaLLRPGDTVVV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 177 GDDVYGGSDRLLSQVVPRSGVVVKRVNTtklDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 256
Cdd:PRK07582 95 PADGYYQVRALAREYLAPLGVTVREAPT---AGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQ 336
Cdd:PRK07582 172 ATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQC 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 337 ENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVkslismp 416
Cdd:PRK07582 252 ANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFELADAAAAERFVAASRLVVAATSFGGV------- 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15230203 417 cfmsHASipAEVREARG--LTEDLVRISAGIEDVDDLISDLDIA 458
Cdd:PRK07582 325 ----HTS--ADRRARWGdaVPEGFVRLSCGIEDTDDLVADLERA 362
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
103-461 |
8.22e-86 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 267.85 E-value: 8.22e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATFKQPsaiENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT-HLIKNGEEIVAGDDVY 181
Cdd:PRK06460 18 AITTPIYQTTAYHYP---EGEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTAlALLKPGNSVLVHRDMF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 182 GGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVL 261
Cdd:PRK06460 95 GRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATFSTPIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 262 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEkLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 341
Cdd:PRK06460 175 QKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGK-LLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQ 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 342 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 420
Cdd:PRK06460 254 IAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFeVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMS 333
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15230203 421 HASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKT 461
Cdd:PRK06460 334 HRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALST 374
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
99-461 |
1.54e-85 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 268.92 E-value: 1.54e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 99 DP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLI 168
Cdd:PRK08134 21 DPaTGARAVPIHLTTSFVFRDSdhaaalfnLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHlAIATLM 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 169 KNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGA 248
Cdd:PRK08134 101 GAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPTVAAIAHEAGV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 249 LVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG----EKLAK-----EVY-------FLQNSE--- 309
Cdd:PRK08134 181 PLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGrfdwEASGKfpeltEPYagfhgmvFAEESTvaa 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 310 -------------GSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLhfsqAK-- 374
Cdd:PRK08134 261 fllrarreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHAL----AKrl 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 375 ---GAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDD 450
Cdd:PRK08134 337 lprGAGSVFSFdLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIGLEDADD 416
|
410
....*....|.
gi 15230203 451 LISDLDIAFKT 461
Cdd:PRK08134 417 LIDDLKRALKA 427
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
100-460 |
3.23e-85 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 267.37 E-value: 3.23e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 100 PFDAMSTPLYQTATFKQPSAIE-----NGPYD---YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLIKN 170
Cdd:PRK07810 29 GFEETAEALYLTSGYVYESAAAaeaafTGELDrfvYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVfTALGALLGA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 171 GEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALV 250
Cdd:PRK07810 109 GDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKV 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 251 LVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMAL 330
Cdd:PRK07810 189 VLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLAL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 331 RIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKH----LVETTKYFSIAVS 405
Cdd:PRK07810 269 RVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFeLDAPEDAAKKrafeVLDKLRVIDISNN 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15230203 406 FGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK07810 349 LGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
103-459 |
4.96e-84 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 265.08 E-value: 4.96e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 167
Cdd:PRK07812 31 ARALPIYQTTSYtfddtdhaaalfglAEPGNI------YTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETfAILNL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 168 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-NTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQ 246
Cdd:PRK07812 105 AGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLDIPGVAEVAHEA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 247 GALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVL------------------------AVKGEKLAKEV 302
Cdd:PRK07812 185 GVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpgfttpdpsyhGVVFAELGPPA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 303 YFLQ------NSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQA-KG 375
Cdd:PRK07812 265 YALKarvqllRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYERAKRLApKG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 376 AGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISD 454
Cdd:PRK07812 345 TGAVLSFeLAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAVGIEGIDDILAD 424
|
....*
gi 15230203 455 LDIAF 459
Cdd:PRK07812 425 LEAGF 429
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
88-459 |
2.36e-82 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 260.42 E-value: 2.36e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 88 STLLVNLDNKFDPFD-AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAF 152
Cdd:PRK05994 9 ATLAVHAGAQPDPTTgARATPIYQTTSFvfndadhaaslfglQAFGNI------YTRITNPTNAVLEERVAALEGGTAAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 153 CFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQ 231
Cdd:PRK05994 83 AVASGHAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 232 QISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGE--------------- 296
Cdd:PRK05994 163 TVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTfdwsksgkypmlsep 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 297 ------------------KLAKEVYFLQNSeGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYA 358
Cdd:PRK05994 243 rpeyhglvlhetfgnfafAIAARVLGLRDL-GPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 359 GLPDHPGHHLHFSQA-KGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTE 436
Cdd:PRK05994 322 GLPDDPYHALAQKYSpKGAGAVFTFgLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGP 401
|
410 420
....*....|....*....|...
gi 15230203 437 DLVRISAGIEDVDDLISDLDIAF 459
Cdd:PRK05994 402 DVVRLSIGIEDVDDIIADLEQAL 424
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
99-459 |
1.65e-80 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 254.44 E-value: 1.65e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 99 DP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLI 168
Cdd:PRK06434 21 DPrFGNVTTPIFETSTFVYPNSekeaymdsTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAItSAILSLI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 169 KNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAaaIGPQT-KLVWLESPTNPRQQISDIRKISEMAHaqG 247
Cdd:PRK06434 101 KKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLD--FDPSNyDLIYAESITNPTLKVPDIKNVSSFCH--E 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 248 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKT 327
Cdd:PRK06434 177 NDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQAYLALRGLKT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 328 MALRIEKQQENARKIAMYLSSHPRVKKVYYaglpdhPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFG 407
Cdd:PRK06434 257 LGLRMEKHNKNGMELARFLRDSKKISNVYY------PDTEIGKKVLRGFGGMLSFELRSMEDVHKFIRNLEIPMVAASLG 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 15230203 408 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
Cdd:PRK06434 331 GVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENAL 382
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
100-461 |
1.52e-79 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 252.37 E-value: 1.52e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 100 PFDAMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKN 170
Cdd:PRK07504 24 QFGETSEALFLTQGFVYDTAEaaearfkgEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTaAILCQVKA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 171 GEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALV 250
Cdd:PRK07504 104 GDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 251 LVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEV--YFLQNseGSGLAPFDCWLCLRGIKTM 328
Cdd:PRK07504 184 VVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEHLqdYFRHT--GPSLSPFNAWTLLKGLETL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 329 ALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFG 407
Cdd:PRK07504 262 PVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFeLKGGKEAAFRFLNALKIVRISNNLG 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15230203 408 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKT 461
Cdd:PRK07504 342 DAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKK 395
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
88-459 |
4.85e-79 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 251.90 E-value: 4.85e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 88 STLLVNLDnkFDPF---DAMSTPLYQTATF------------------KQPSAIENGPYDYTRSGNPTRDALESLLAKLD 146
Cdd:PRK07049 19 ETQMLNYG--YDPElseGAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRLAVYE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 147 KADRAFCFTSGMAALSAVT-HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVV-------VKRVNTTKLDEVAAAIGPqT 218
Cdd:PRK07049 97 GAESAALFSSGMSAIATTLlAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGavgfadgLSEAAIGAAAEAAAAKGR-V 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 219 KLVWLESPTNPRQQISDIRKISEMAHAQGA------LVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvlA 292
Cdd:PRK07049 176 SLILIETPANPTNSLVDVAAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAG--A 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 293 VKGEK-LAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGL--PDHPGHHLH 369
Cdd:PRK07049 254 VLGRKaLIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVY 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 370 FSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDV 448
Cdd:PRK07049 334 KRQCTGAGSTFSFdIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHP 413
|
410
....*....|.
gi 15230203 449 DDLISDLDIAF 459
Cdd:PRK07049 414 DDLIADLAQAL 424
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
91-460 |
8.31e-77 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 244.99 E-value: 8.31e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 91 LVNLDNKFDPFDAMSTPLYQTATFKQPS--------AIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS 162
Cdd:PRK05968 13 LITAHDEGNAFDAVVPPIFQTSLFTFDSydemedvyAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAIS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 163 A-VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIgPQTKLVWLESPTNPRQQISDIRKISE 241
Cdd:PRK05968 93 StVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 242 MAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAK---EVY-FLqnseGSGLAPFD 317
Cdd:PRK05968 172 LAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARinaEAYpYL----GAKLSPFE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 318 CWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHfsqakGAGSVFSFITGSVALSKHLVETT 397
Cdd:PRK05968 248 AWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGLS-----GTSGLFSFIFREGIDVRAFADAL 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15230203 398 KYFSIAVSFGSVKSLIsmpcfmshasIPAEVR----------EARGLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK05968 323 KLFRLGVSWGGHESLV----------VPAEVVlqqkaqpnsaARFGVSPRSVRLHVGLEGTEALWADLEQALA 385
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
79-460 |
9.45e-76 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 243.60 E-value: 9.45e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 79 MNIKEEASVSTLLVNLDNKFDPFD-AMSTPLYQTAT--FKQPS------AIENGPYDYTRSGNPTRDALESLLAKLDKAD 149
Cdd:PRK08248 1 MSEERTFRLETLAIHAGQEIDPTTgSRAVPIYQTTSygFRDSEhaanlfSLKEFGNIYTRIMNPTTDVFEKRIAALEGGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 150 RAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTN 228
Cdd:PRK08248 81 GALAVSSGQAAITySILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 229 PRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG------------- 295
Cdd:PRK08248 161 PKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGkfdwkgsgkfpgl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 296 -------------EKLAKEVYFLQ------NSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVY 356
Cdd:PRK08248 241 tepdpsyhglvytDAVGEAAYITKarvqllRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 357 YAGLPDHPGHHLHFSQ-AKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGL 434
Cdd:PRK08248 321 YPGLPSHPSYELAKKYlPKGQGAILTFgIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGV 400
|
410 420
....*....|....*....|....*.
gi 15230203 435 TEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK08248 401 TPGLVRLSVGTEAIDDILDDLRQAIR 426
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
103-459 |
2.38e-72 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 234.80 E-value: 2.38e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 167
Cdd:PRK06084 20 AVAVPIYQTTSYafddtqhgadlfdlKVPGNI------YTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITyAIQTI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 168 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG 247
Cdd:PRK06084 94 AEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQALADAAHRHG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 248 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGE---KLAKEVYFLQN----------------- 307
Cdd:PRK06084 174 VPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKfpwAEHKERFALLNtpdpsyhgvtyteafgp 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 308 -------------SEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAK 374
Cdd:PRK06084 254 aafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHELARRYMG 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 375 GA-GSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLI 452
Cdd:PRK06084 334 GKpASILSFgIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRLSIGIEHIDDII 413
|
....*..
gi 15230203 453 SDLDIAF 459
Cdd:PRK06084 414 ADLAQAL 420
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
123-461 |
8.56e-71 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 229.57 E-value: 8.56e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 123 GPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDDVYGGSDRLLsQVVPRSGVVVKR 201
Cdd:PRK05939 37 PGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVfLTLLRAGDHLVSSQFLFGNTNSLF-GTLRGLGVEVTM 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 202 VNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIA 281
Cdd:PRK05939 116 VDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 282 GHSDVMAGVLAVKGE------KLAKEVYFLQNSEGSGLAPF------DCWLCLR---------GIKTMALRIEKQQENAR 340
Cdd:PRK05939 196 GHGNALGGAVTDTGLfdwsayPNIFPAYRKGDPQQWGLTQIrkkglrDMGATLSseaahriaiGAETLALRVDRSCSNAL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 341 KIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLIsmpcfms 420
Cdd:PRK05939 276 ALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGIDCFDFLNRLKLVIKATHLGDTRTLV------- 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 15230203 421 hasIP----------AEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKT 461
Cdd:PRK05939 349 ---IPvaptiyyemgAERRASMGIADSLIRVSVGIEDEADLIADFEQALDA 396
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
103-459 |
4.01e-66 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 218.59 E-value: 4.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 103 AMSTPLYQTATF--------KQPSAIEN-GPYdYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGE 172
Cdd:PRK05613 31 ARNLPIYQTTSYvfdsaehaKQRFALEDlGPI-YSRLTNPTVEALENRIASLEGGVHAVAFASGQAAETaAILNLAGAGD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 173 EIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-NTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 251
Cdd:PRK05613 110 HIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVLDIPAVAEVAHRNQVPLI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG------EKLAKEV--YF------------------- 304
Cdd:PRK05613 190 VDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGkfdwtvERDGKPVfpYFvtpdpayhglkyadlgapa 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 305 --------LQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQA-KG 375
Cdd:PRK05613 270 fglkaragLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKDSPWYATKEKLGlKY 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 376 AGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISD 454
Cdd:PRK05613 350 TGSVLSFdIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQATVRLSVGIEDIDDIIAD 429
|
....*
gi 15230203 455 LDIAF 459
Cdd:PRK05613 430 LEGGF 434
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
77-459 |
3.34e-59 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 199.26 E-value: 3.34e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 77 NTMNIKEEASVSTLLVNLDNkfDPFDA---MSTPLYQTATFKQPSA----IENGPYDYTRSGNPTRDALESLLAKLDKAD 149
Cdd:PRK05967 3 KKQLKTEKAGINTRLAHDGN--DPGDYhgfVNPPVVHASTVLFPDAetmaTRGQKYTYGTRGTPTTDALCKAIDALEGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 150 RAFCFTSGMAALSA-VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTN 228
Cdd:PRK05967 81 GTILVPSGLAAVTVpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 229 PRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKgEKLAKEVYFLQNS 308
Cdd:PRK05967 161 NTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSAN-EKCWPQLLEAHGT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 309 EGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVA 388
Cdd:PRK05967 240 LGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGP 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15230203 389 LSKH-----LVETTKYFSIAVSFGSVKSLismpcfMSHASIpAEVREARGLTED-LVRISAGIEDVDDLISDLDIAF 459
Cdd:PRK05967 320 EKGKakahaFLDALEIFGLGYSWGGYESL------ALHVKL-GDRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGF 389
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
101-458 |
3.38e-59 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 199.18 E-value: 3.38e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 101 FDAMSTPLYQTATFKQPSAIE--------NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNG 171
Cdd:PRK07050 25 FRSFVTPVARASTVVFPDLATmraldwrqDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVYFgLVKAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 251
Cdd:PRK07050 105 DDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 331
Cdd:PRK07050 185 IDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 332 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITG---SVALSKHLVETTKYFSIAVSFGS 408
Cdd:PRK07050 265 LAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDerySPAQVDAFVEALELFAIGWSWGG 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15230203 409 VKSLismpcfmshaSIPAEVREARGLTED----LVRISAGIEDVDDLISDLDIA 458
Cdd:PRK07050 345 ACSL----------AMPYDVASMRTAKWPhrgtLVRLYIGLEDEADLIADLEQA 388
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
105-462 |
8.77e-55 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 187.63 E-value: 8.77e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 105 STPLYQTATFKQPSAIE--NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVY 181
Cdd:PRK09028 31 STVVFDTVAEMRHAAKNraNGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISnALLSFLKAGDHLLMVDSCY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 182 GGSDRLLSQVVPRSGVvvkrvNTTKLDE-----VAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 256
Cdd:PRK09028 111 EPTRDLCDKILKGFGI-----ETTYYDPmigegIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVlAVKGEKlakevYFLQNSEGSGL-----APFDCWLCLRGIKTMALR 331
Cdd:PRK09028 186 ASPINSRPFEMGVDISIQAATKYIVGHSDVMLGT-ATANEK-----HWDQLREHSYLmgqctSPDDVYLAMRGLRTLGVR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 332 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFI--TGSVALSKHLVETTKYFSIAVSFGSV 409
Cdd:PRK09028 260 LAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVlkQGDPKAVTALVEGMQHFKMGFSWGGF 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 15230203 410 KSLIsmpcfMSHASIPAeVREAR--GLTEDLVRISAGIEDVDDLISDLDIAFKTF 462
Cdd:PRK09028 340 ESLI-----LGVFGINK-LRTATnwDFSKPLIRLHIGLEDVDDLIADLEAGFERY 388
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
104-445 |
8.63e-54 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 185.74 E-value: 8.63e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 104 MSTPLYQTATFKQPSAI------ENGP----YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGE 172
Cdd:PLN02242 37 MSIEASATFTVMEPDTMrrmfsgELGPdrdfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVlLQLCSSGG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 173 EIVAGDDVYGGSDRLLSQVVPR-SGVVVKRVNTTKLDEVAAAIGP-QTKLVWLESPTNPRQQISDIRKISEMAHAQGALV 250
Cdd:PLN02242 117 HVVASNTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTV 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 251 LVDNSiMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvlAVKG-EKLAKEVYFLQNSEGSGLAP-------FDcwLCL 322
Cdd:PLN02242 197 VVDNT-FAPMVLSPARLGADVVVHSISKFISGGADIIAG--AVCGpAELVNSMMDLHHGALMLLGPtmnpkvaFE--LSE 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 323 RgIKTMALRIekqQENARKIAMYLSshpRVK----KVYYAGLPDHPGHHLHFSQAK---GAGSVFSFITGSVA----LSK 391
Cdd:PLN02242 272 R-LPHLSLRM---KEHCRRAMEYAK---RMKelglKVIYPGLEDHPQHALLKSMANkgyGFGGLLCLDMDTEEranrLMR 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 15230203 392 HLVETTKYFSIAVSFGSVKSLisMPCFMSHAS--IPAEVREARGLTEDLVRISAGI 445
Cdd:PLN02242 345 YLQNSTQFGFMAVSLGYYETL--MSCSGSSTSseLDPEEKAAAGISPGLVRMSVGY 398
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
107-459 |
5.51e-49 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 173.32 E-value: 5.51e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 107 PLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAG 177
Cdd:PRK06702 27 PLYQSTTYKYDTSddlaalfnLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMlAVLNICSSGDHLLCS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 178 DDVYGGSDRLLSQVVPRSGVVVKRVNTT-KLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 256
Cdd:PRK06702 107 STVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLA---------------VKGEKLAKEVYFLQN-------------- 307
Cdd:PRK06702 187 ATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSYHGVSYVQNfgaaayivkarvql 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 308 --SEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ-AKGAGSVFSF-I 383
Cdd:PRK06702 267 lrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYlKKGASGVLTFgI 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15230203 384 TGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
Cdd:PRK06702 347 KGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
122-460 |
1.40e-44 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 160.64 E-value: 1.40e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 122 NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVvvk 200
Cdd:PRK08114 51 NGELFYGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVAnAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGV--- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 201 rvNTTKLD-----EVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG--ALVLVDNSIMSPVLSRPLELGADIVM 273
Cdd:PRK08114 128 --TTTWFDpligaDIAKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISI 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 274 HSATKFIAGHSDVMAGVlAVKG----EKLAKEVYFLqnseGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSH 349
Cdd:PRK08114 206 QAGTKYLVGHSDAMIGT-AVANarcwEQLRENSYLM----GQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEH 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 350 PRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFItgsvaLSKHLVETT--------KYFSIAVSFGSVKSLISmpcfmsh 421
Cdd:PRK08114 281 PEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFV-----LKKKLTDEQlanyldnfSLFSMAYSWGGFESLIL------- 348
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15230203 422 ASIPAEVREAR-----GLTEDLVRISAGIEDVDDLISDLDIAFK 460
Cdd:PRK08114 349 ANQPEEIAAIRpagevDFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
135-294 |
4.15e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 61.24 E-value: 4.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 135 RDALESLLAKL--DKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSdrlLSQVVPRSGVVVKRVNTTK----- 206
Cdd:cd01494 2 LEELEEKLARLlqPGNDKAVFVPSGTGANEAALLaLLGPGDEVIVDANGHGSR---YWVAAELAGAKPVPVPVDDagygg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 207 ---LDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNS----IMSPVLSRPLELGADIVMHSATKF 279
Cdd:cd01494 79 ldvAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAAsaggASPAPGVLIPEGGADVVTFSLHKN 158
|
170
....*....|....*
gi 15230203 280 IAGhsdVMAGVLAVK 294
Cdd:cd01494 159 LGG---EGGGVVIVK 170
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
136-253 |
3.54e-07 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 51.92 E-value: 3.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 136 DALESLLAKL--------DKADRAFCFTSGM-AALSAVTHLIKNGEEIVAGDDVYGGSdrlLSQVVPRSGVVVKRVNTTK 206
Cdd:pfam00155 42 PELREALAKFlgrspvlkLDREAAVVFGSGAgANIEALIFLLANPGDAILVPAPTYAS---YIRIARLAGGEVVRYPLYD 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 15230203 207 -------LDEVAAAIGPQTKLVWLESPTNPRQQI---SDIRKISEMAHAQGALVLVD 253
Cdd:pfam00155 119 sndfhldFDALEAALKEKPKVVLHTSPHNPTGTVatlEELEKLLDLAKEHNILLLVD 175
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
154-253 |
4.69e-07 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 51.68 E-value: 4.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 154 FTSGM-AALSAVTH---LIKNGEEIVAGDDVYGGSD---RLLSQvvpRSGVVVKRVNTTK-----LDEVAAAIGPQTKLV 221
Cdd:COG0520 82 FTRGTtEAINLVAYglgRLKPGDEILITEMEHHSNIvpwQELAE---RTGAEVRVIPLDEdgeldLEALEALLTPRTKLV 158
|
90 100 110
....*....|....*....|....*....|..
gi 15230203 222 WLESPTNPRQQISDIRKISEMAHAQGALVLVD 253
Cdd:COG0520 159 AVTHVSNVTGTVNPVKEIAALAHAHGALVLVD 190
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
204-272 |
7.52e-07 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 51.29 E-value: 7.52e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 204 TTKLDEVAAAIGPQTKLVWLESPtNPRQQISDIRKISEMAHAQGAL-VLVDNSIMSPVLSRPLELGADIV 272
Cdd:PRK00451 191 VTDLEALEAAVDDDTAAVVVQYP-NFFGVIEDLEEIAEIAHAGGALfIVGVDPVSLGLLKPPGEYGADIV 259
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
154-281 |
1.12e-06 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 50.71 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 154 FTSG------MAALSAVTHLiKNGEEIVAGDDVYGgsdrllSQVVP------RSGVVVKRVNTTK-----LDEVAAAIGP 216
Cdd:pfam00266 66 FTSGtteainLVALSLGRSL-KPGDEIVITEMEHH------ANLVPwqelakRTGARVRVLPLDEdglldLDELEKLITP 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15230203 217 QTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSimSPVLSRPL---ELGADIVMHSATKFIA 281
Cdd:pfam00266 139 KTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA--QAIGHRPIdvqKLGVDFLAFSGHKLYG 204
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
194-270 |
3.36e-06 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 49.00 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 194 RSGVVVKRVNTTK-----LDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLsrPL--- 265
Cdd:cd06453 111 RTGAKLKVVPVDDdgqldLEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVDGAQSAGHM--PVdvq 188
|
....*
gi 15230203 266 ELGAD 270
Cdd:cd06453 189 DLGCD 193
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
204-272 |
6.26e-06 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 48.49 E-value: 6.26e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 204 TTKLDEVAAAIGPQTKLVWLESPtNPRQQISDIRKISEMAHAQGALVLVDNSIMS-PVLSRPLELGADIV 272
Cdd:COG0403 192 VTDLEALKALLDDDVAGVLVQYP-NFFGVIEDLRAIAEAAHAAGALVIVAADPLSlGLLKPPGELGADIV 260
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
119-295 |
6.34e-06 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 48.20 E-value: 6.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 119 AIENGPYDYTRS-GNP-TRDALESLLAK-----LDkADRAFCFTSGMAALS-AVTHLIKNGEEIVAGD---DVYGGSDRL 187
Cdd:COG0436 55 ALDDGVTGYTPSaGIPeLREAIAAYYKRrygvdLD-PDEILVTNGAKEALAlALLALLNPGDEVLVPDpgyPSYRAAVRL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 188 LsqvvprsGVVVKRVNTTK-------LDEVAAAIGPQTKLVWLESPTNP------RqqiSDIRKISEMAHAQGALVLVDN 254
Cdd:COG0436 134 A-------GGKPVPVPLDEengflpdPEALEAAITPRTKAIVLNSPNNPtgavysR---EELEALAELAREHDLLVISDE 203
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15230203 255 -------------SIMSpvlsrpLELGAD--IVMHSATK----------FIAGHSDVMAGVLAVKG 295
Cdd:COG0436 204 iyeelvydgaehvSILS------LPGLKDrtIVINSFSKsyamtgwrigYAVGPPELIAALLKLQS 263
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
125-432 |
2.63e-05 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 46.18 E-value: 2.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 125 YDYTRSGNPTRDALESLLAK----LDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRLLSQVvprsGVVV 199
Cdd:cd00609 32 YYPDPGLPELREAIAEWLGRrggvDVPPEEIVVTNGAQEALSLLLRaLLNPGDEVLVPDPTYPGYEAAARLA----GAEV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 200 KRVNTTK-------LDEVAAAIGPQTKLVWLESPTNP------RQQisdIRKISEMAHAQGALVLVDNS----IMSPVLS 262
Cdd:cd00609 108 VPVPLDEeggflldLELLEAAKTPKTKLLYLNNPNNPtgavlsEEE---LEELAELAKKHGILIISDEAyaelVYDGEPP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 263 RPLELGAD----IVMHSATKFIAghsdvMA----GVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEK 334
Cdd:cd00609 185 PALALLDAyervIVLRSFSKTFG-----LPglriGYLIAPPEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGEEHLEE 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 335 QQENARKIAMYLsshprvkkvyYAGLPDHPGHHLHFSQakgaGSVFSFI----TGSVALSKHLVETTKyfsIAVSFGSVK 410
Cdd:cd00609 260 LRERYRRRRDAL----------LEALKELGPLVVVKPS----GGFFLWLdlpeGDDEEFLERLLLEAG---VVVRPGSAF 322
|
330 340
....*....|....*....|...
gi 15230203 411 SLISMPCF-MSHASIPAEVREAR 432
Cdd:cd00609 323 GEGGEGFVrLSFATPEEELEEAL 345
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
132-301 |
3.49e-05 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 45.70 E-value: 3.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 132 NPTRDALES--LLAKLDKADRAFCFTSG-----MAALSAVthlIKNGEEIVAGDD----VYGGSDrlLSQVVPrsgVVVK 200
Cdd:cd00615 56 DPTGPIKEAqeLAARAFGAKHTFFLVNGtsssnKAVILAV---CGPGDKILIDRNchksVINGLV--LSGAVP---VYLK 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 201 -RVNttKLDEVAAAIGPQT-----------KLVWLESPTnPRQQISDIRKISEMAHAQGALVLVDNS-----IMSPVL-S 262
Cdd:cd00615 128 pERN--PYYGIAGGIPPETfkkaliehpdaKAAVITNPT-YYGICYNLRKIVEEAHHRGLPVLVDEAhgahfRFHPILpS 204
|
170 180 190
....*....|....*....|....*....|....*....
gi 15230203 263 RPLELGADIVMHSATKFIAGHSdvMAGVLAVKGEKLAKE 301
Cdd:cd00615 205 SAAMAGADIVVQSTHKTLPALT--QGSMIHVKGDLVNPD 241
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
91-287 |
3.55e-05 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 45.89 E-value: 3.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 91 LVNLDNkfdpfdamstplyqTATFKQPSAIENGPYDYTRSGNPT------------RDALESLLAKLD-----KADRAFC 153
Cdd:PLN02855 33 LVYLDN--------------AATSQKPAAVLDALQDYYEEYNSNvhrgihalsakaTDAYELARKKVAafinaSTSREIV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 154 FTSGMAA---LSAVTHLIKNgeeIVAGDDVYGGSDRLLSQVVP------RSGVVVKRVNTTK-----LDEVAAAIGPQTK 219
Cdd:PLN02855 99 FTRNATEainLVAYTWGLAN---LKPGDEVILSVAEHHSNIVPwqlvaqKTGAVLKFVGLTPdevldVEQLKELLSEKTK 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15230203 220 LVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLE-LGADIVMHSATK--------FIAGHSDVM 287
Cdd:PLN02855 176 LVATHHVSNVLGSILPVEDIVHWAHAVGAKVLVDACQSVPHMPVDVQtLGADFLVASSHKmcgptgigFLWGKSDLL 252
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
196-295 |
4.38e-05 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 45.51 E-value: 4.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 196 GVVVKRVNTTK-----LDEVAAAIGPQTKLVWLESPTNP------RQQISDIRKisemAHAQGALVLVD----------N 254
Cdd:COG0079 110 GAEVVEVPLDEdfsldLDALLAAITERTDLVFLCNPNNPtgtllpREELEALLE----ALPADGLVVVDeayaefvpeeD 185
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 15230203 255 SIMSPVLSRP-LelgadIVMHSATKF--IAG--------HSDVMAGVLAVKG 295
Cdd:COG0079 186 SALPLLARYPnL-----VVLRTFSKAygLAGlrlgyaiaSPELIAALRRVRG 232
|
|
| f2_encap_cargo1 |
NF041166 |
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like ... |
207-253 |
8.52e-05 |
|
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like encapsulin nanocompartments are commonly found in bacteria and archaea. Encapsulin nanocompartments, which are assembled from shell proteins, encapsulate various cargo proteins, typically peroxidases or ferritin-like proteins, to protect cells from oxidative stress caused by peroxide. Proteins of this family are cysteine desulfurases with an additional N-terminal encapsulation targeting sequence (~200 aa) that is necessary and sufficient for compartmentalization.
Pssm-ID: 469077 [Multi-domain] Cd Length: 623 Bit Score: 44.84 E-value: 8.52e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 15230203 207 LDEVAAAIGPQTKLVwleSPTnprqQISD-------IRKISEMAHAQGALVLVD 253
Cdd:NF041166 376 LDEYAKLLNPRTKLV---SVT----QVSNalgtvtpVKEIIALAHRAGAKVLVD 422
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
133-253 |
2.66e-04 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 42.98 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 133 PTRDALESLLAKLD----KADRAFCFTSG--MAALSAVTHLIKNGEEIVAGDDVYggsDRLLSQVVPRSGVVVK------ 200
Cdd:PRK09082 71 ALREAIAAKTARLYgrqyDADSEITVTAGatEALFAAILALVRPGDEVIVFDPSY---DSYAPAIELAGGRAVRvalqpp 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 15230203 201 --RVNttkLDEVAAAIGPQTKLVWLESPTNPRQQI---SDIRKISEMAHAQGALVLVD 253
Cdd:PRK09082 148 dfRVD---WQRFAAAISPRTRLIILNTPHNPSGTVwsaADMRALWQLIAGTDIYVLSD 202
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
235-296 |
5.44e-04 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 42.22 E-value: 5.44e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15230203 235 DIRKISEMAHAQGALVLVDNSIMS-PVLSRPLELGADIVMHSATKFIAGHS--DVMAGVLAVKGE 296
Cdd:cd00613 177 LIKEIADIAHSAGALVYVDGDNLNlTGLKPPGEYGADIVVGNLQKTGVPHGggGPGAGFFAVKKE 241
|
|
| PRK04366 |
PRK04366 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPB; |
207-274 |
6.27e-04 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
Pssm-ID: 235292 Cd Length: 481 Bit Score: 42.02 E-value: 6.27e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15230203 207 LDEVAAAIGPQTKLVWLespTNP-------RqqisDIRKISEMAHAQGALVLVD----NSIMSPVlsRPLELGADiVMH 274
Cdd:PRK04366 198 LEALKAAVGEDTAALML---TNPntlglfeR----NILEIAEIVHEAGGLLYYDganlNAILGKA--RPGDMGFD-VVH 266
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
155-253 |
8.89e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 41.56 E-value: 8.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 155 TSGMAAlsAVTHLIKNGEEIVAGDDVY----------GGSDRLLSQVVPRSGVVVKrvnttkLDEVAAAIGPQTKLVWLE 224
Cdd:PRK07777 95 TEAIAA--AVLGLVEPGDEVLLIEPYYdsyaaviamaGAHRVPVPLVPDGRGFALD------LDALRAAVTPRTRALIVN 166
|
90 100 110
....*....|....*....|....*....|..
gi 15230203 225 SPTNPRQQI---SDIRKISEMAHAQGALVLVD 253
Cdd:PRK07777 167 SPHNPTGTVltaAELAAIAELAVEHDLLVITD 198
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
204-296 |
2.75e-03 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 40.05 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 204 TTKLDEVAAAIgpqtklvwLESPtNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSR-PLELGADIVMHSATKF--I 280
Cdd:pfam02347 192 VTDLKDVFGVL--------VQYP-NTDGRIEDYKELIELAHQRKSLVVVAADLLALTLLKpPGEFGADIAVGSAQRFgvP 262
|
90
....*....|....*.
gi 15230203 281 AGHSDVMAGVLAVKGE 296
Cdd:pfam02347 263 LGYGGPHAGFFAVKKE 278
|
|
| SepCysS |
cd06452 |
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent ... |
192-296 |
3.79e-03 |
|
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Cys-tRNA(Cys) is produced by O-phosphoseryl-tRNA synthetase which ligates O-phosphoserine (Sep) to tRNA(Cys), and Sep-tRNA:Cys-tRNA synthase (SepCysS) converts Sep-tRNA(Cys) to Cys-tRNA(Cys), in methanogenic archaea. SepCysS forms a dimer, each monomer is composed of a large and small domain; the larger, a typical pyridoxal 5'-phosphate (PLP)-dependent-like enzyme fold. In the active site of each monomer, PLP is covalently bound to a conserved Lys residue near the dimer interface.
Pssm-ID: 99745 Cd Length: 361 Bit Score: 39.30 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230203 192 VPRSGVVVKRVN----TTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNS----IMsPVLSR 263
Cdd:cd06452 110 VPNTGHPEYHITpegyAEVIEEVKDEFGKPPALALLTHVDGNYGNLHDAKKIAKVCHEYGVPLLLNGAytvgRM-PVSGK 188
|
90 100 110
....*....|....*....|....*....|...
gi 15230203 264 plELGADIVMHSATKFIAGHSDVmaGVLAVKGE 296
Cdd:cd06452 189 --ELGADFIVGSGHKSMAASAPI--GVLATTEE 217
|
|
| |
