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Conserved domains on  [gi|15230300|ref|NP_191301|]
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transmembrane protein, putative (DUF288) [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STELLO super family cl15553
STELLO glycosyltransferases; This domain family is found in Metazoa and in Virdiplantae. Two ...
 352-459 7.49e-05

STELLO glycosyltransferases; This domain family is found in Metazoa and in Virdiplantae. Two of the family members are characterized in Arabidopsis thaliana, named STELLO1 (STL1) and STELLO2 (STL2) respectively. They are Golgi-localized proteins that can interact with CesAs (cellulose synthase A) and control cellulose quantity. In the absence of STELLO function, the spatial distribution within the Golgi, secretion and activity of the CSCs are impaired indicating a central role of the STELLO proteins in CSC assembly. Point mutations in the predicted catalytic domains of the STELLO proteins indicate that they are glycosyltransferases facing the Golgi lumen. STL homologs are present throughout the plant kingdom, but STL proteins are distinct from distantly related proteins in nematodes, fungi and molluscs.


The actual alignment was detected with superfamily member pfam03385:

Pssm-ID: 427273  Cd Length: 387  Bit Score: 45.87  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230300   352 SDVIRGYWGQRLLwELGGYVAVYPPT-------VHRYDRveayPFSDEKDLHINVGRLIKFLLAWR-SNKHRFFETILDL 423
Cdd:pfam03385   3 TDIWRSFISQKIL-HLSGLTVSFVPTnavqfrnAHDYLK----DFKDEKQVYEDSGKMIEFLHNWKcSNGNSLENCINQL 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15230300   424 SFVMAEQGFWTELDVKFTAAWLQDLLMVGYQQPRLM 459
Cdd:pfam03385  78 LNDLVEVKLWGEEDAKLMEMFLNDLKSMGFEFPKLI 113
 
Name Accession Description Interval E-value
STELLO pfam03385
STELLO glycosyltransferases; This domain family is found in Metazoa and in Virdiplantae. Two ...
 352-459 7.49e-05

STELLO glycosyltransferases; This domain family is found in Metazoa and in Virdiplantae. Two of the family members are characterized in Arabidopsis thaliana, named STELLO1 (STL1) and STELLO2 (STL2) respectively. They are Golgi-localized proteins that can interact with CesAs (cellulose synthase A) and control cellulose quantity. In the absence of STELLO function, the spatial distribution within the Golgi, secretion and activity of the CSCs are impaired indicating a central role of the STELLO proteins in CSC assembly. Point mutations in the predicted catalytic domains of the STELLO proteins indicate that they are glycosyltransferases facing the Golgi lumen. STL homologs are present throughout the plant kingdom, but STL proteins are distinct from distantly related proteins in nematodes, fungi and molluscs.


Pssm-ID: 427273  Cd Length: 387  Bit Score: 45.87  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230300   352 SDVIRGYWGQRLLwELGGYVAVYPPT-------VHRYDRveayPFSDEKDLHINVGRLIKFLLAWR-SNKHRFFETILDL 423
Cdd:pfam03385   3 TDIWRSFISQKIL-HLSGLTVSFVPTnavqfrnAHDYLK----DFKDEKQVYEDSGKMIEFLHNWKcSNGNSLENCINQL 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15230300   424 SFVMAEQGFWTELDVKFTAAWLQDLLMVGYQQPRLM 459
Cdd:pfam03385  78 LNDLVEVKLWGEEDAKLMEMFLNDLKSMGFEFPKLI 113
 
Name Accession Description Interval E-value
STELLO pfam03385
STELLO glycosyltransferases; This domain family is found in Metazoa and in Virdiplantae. Two ...
 352-459 7.49e-05

STELLO glycosyltransferases; This domain family is found in Metazoa and in Virdiplantae. Two of the family members are characterized in Arabidopsis thaliana, named STELLO1 (STL1) and STELLO2 (STL2) respectively. They are Golgi-localized proteins that can interact with CesAs (cellulose synthase A) and control cellulose quantity. In the absence of STELLO function, the spatial distribution within the Golgi, secretion and activity of the CSCs are impaired indicating a central role of the STELLO proteins in CSC assembly. Point mutations in the predicted catalytic domains of the STELLO proteins indicate that they are glycosyltransferases facing the Golgi lumen. STL homologs are present throughout the plant kingdom, but STL proteins are distinct from distantly related proteins in nematodes, fungi and molluscs.


Pssm-ID: 427273  Cd Length: 387  Bit Score: 45.87  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15230300   352 SDVIRGYWGQRLLwELGGYVAVYPPT-------VHRYDRveayPFSDEKDLHINVGRLIKFLLAWR-SNKHRFFETILDL 423
Cdd:pfam03385   3 TDIWRSFISQKIL-HLSGLTVSFVPTnavqfrnAHDYLK----DFKDEKQVYEDSGKMIEFLHNWKcSNGNSLENCINQL 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15230300   424 SFVMAEQGFWTELDVKFTAAWLQDLLMVGYQQPRLM 459
Cdd:pfam03385  78 LNDLVEVKLWGEEDAKLMEMFLNDLKSMGFEFPKLI 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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