NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|30694985|ref|NP_191498|]
View 

glycosyltransferase family protein [Arabidopsis thaliana]

Protein Classification

SREBP regulating gene protein( domain architecture ID 10562938)

SREBP regulating gene protein positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP

Gene Ontology:  GO:2000640
PubMed:  32111832

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 37-156 4.01e-45

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


:

Pssm-ID: 463004  Cd Length: 128  Bit Score: 148.28  E-value: 4.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694985    37 ERSCRTTVQGRYLISDDEGNVCDALSLESrTRCCPWKG------ERFSCHGCNILSQCCNSYEFCVSCCLNPSQTLLEkV 110
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLS-NGCCNTTGvnapttKRYSCDTCNLSSRCCSVYEYCVSCCLHPDKRPLL-E 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 30694985   111 VKVKVAKPATSGTYKSV---FDFCAGRCRHNSESVVHENAYHS-EFHHCF 156
Cdd:pfam10218  79 VVLKKARGRTQVLYGSVtdhFELCLAKCRTSSHSVQHENTYRDpDAKHCY 128
Glyco_transf_18 super family cl20900
Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1, ...
 179-272 1.12e-06

Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.


The actual alignment was detected with superfamily member pfam15024:

Pssm-ID: 434401  Cd Length: 557  Bit Score: 49.20  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694985   179 VIVGSQGDSCDAVCKSRGQLCVMNKLSLLNQCDVMKRY-MNCKGSclaSAGADQPAEVVEDAPRDlypgaCLYTRTQSLL 257
Cdd:pfam15024 471 VLLGEAGQSCKQACQSKGLICEPAFFPHINKPKAFARLgISCSST---ESEMDHLFPAYSPKGRH-----CYLQSDPLLF 542

                          90
                  ....*....|....*
gi 30694985   258 SCDGSHQHTRRLCPC 272
Cdd:pfam15024 543 SCAGSSPSYRRLCPC 557
 
Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 37-156 4.01e-45

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


Pssm-ID: 463004  Cd Length: 128  Bit Score: 148.28  E-value: 4.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694985    37 ERSCRTTVQGRYLISDDEGNVCDALSLESrTRCCPWKG------ERFSCHGCNILSQCCNSYEFCVSCCLNPSQTLLEkV 110
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLS-NGCCNTTGvnapttKRYSCDTCNLSSRCCSVYEYCVSCCLHPDKRPLL-E 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 30694985   111 VKVKVAKPATSGTYKSV---FDFCAGRCRHNSESVVHENAYHS-EFHHCF 156
Cdd:pfam10218  79 VVLKKARGRTQVLYGSVtdhFELCLAKCRTSSHSVQHENTYRDpDAKHCY 128
Glyco_transf_18 pfam15024
Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1, ...
 179-272 1.12e-06

Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.


Pssm-ID: 434401  Cd Length: 557  Bit Score: 49.20  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694985   179 VIVGSQGDSCDAVCKSRGQLCVMNKLSLLNQCDVMKRY-MNCKGSclaSAGADQPAEVVEDAPRDlypgaCLYTRTQSLL 257
Cdd:pfam15024 471 VLLGEAGQSCKQACQSKGLICEPAFFPHINKPKAFARLgISCSST---ESEMDHLFPAYSPKGRH-----CYLQSDPLLF 542

                          90
                  ....*....|....*
gi 30694985   258 SCDGSHQHTRRLCPC 272
Cdd:pfam15024 543 SCAGSSPSYRRLCPC 557
 
Name Accession Description Interval E-value
SPRING1 pfam10218
SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein ...
 37-156 4.01e-45

SREBP regulating gene protein; SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.


Pssm-ID: 463004  Cd Length: 128  Bit Score: 148.28  E-value: 4.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694985    37 ERSCRTTVQGRYLISDDEGNVCDALSLESrTRCCPWKG------ERFSCHGCNILSQCCNSYEFCVSCCLNPSQTLLEkV 110
Cdd:pfam10218   1 STSCRNSVQGKSLIVDDRGYVCSRSELLS-NGCCNTTGvnapttKRYSCDTCNLSSRCCSVYEYCVSCCLHPDKRPLL-E 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 30694985   111 VKVKVAKPATSGTYKSV---FDFCAGRCRHNSESVVHENAYHS-EFHHCF 156
Cdd:pfam10218  79 VVLKKARGRTQVLYGSVtdhFELCLAKCRTSSHSVQHENTYRDpDAKHCY 128
Glyco_transf_18 pfam15024
Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1, ...
 179-272 1.12e-06

Glycosyltransferase family 18; Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme.


Pssm-ID: 434401  Cd Length: 557  Bit Score: 49.20  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694985   179 VIVGSQGDSCDAVCKSRGQLCVMNKLSLLNQCDVMKRY-MNCKGSclaSAGADQPAEVVEDAPRDlypgaCLYTRTQSLL 257
Cdd:pfam15024 471 VLLGEAGQSCKQACQSKGLICEPAFFPHINKPKAFARLgISCSST---ESEMDHLFPAYSPKGRH-----CYLQSDPLLF 542

                          90
                  ....*....|....*
gi 30694985   258 SCDGSHQHTRRLCPC 272
Cdd:pfam15024 543 SCAGSSPSYRRLCPC 557
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH