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Conserved domains on  [gi|22328264|ref|NP_192212|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

kelch repeat domain-containing protein( domain architecture ID 1000219)

kelch repeat domain-containing protein such as human kelch-like protein 1 that may play a role in organizing the actin cytoskeleton of the brain cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
110-381 7.01e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 7.01e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 110 FLFDPVTLSWRSLPLMPcNPHVYGlcnFVAVALGPYVYVLGGsafdtRSYPLDVPLPTSSVFRYSFVKSVWERLSPMMSP 189
Cdd:COG3055  41 EVYDPATNTWSELAPLP-GPPRHH---AAAVAQDGKLYVFGG-----FTGANPSSTPLNDVYVYDPATNTWTKLAPMPTP 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 190 RGSFACAAMPgscGRIIVAGGGSrhtlfgaAGSRMSSVEMYDVEKDEWRVMNELPRFRAGCVGFLVenekekekeeEGRE 269
Cdd:COG3055 112 RGGATALLLD---GKIYVVGGWD-------DGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVL----------PDGK 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 270 FWVMGGYGGSrtvsgilpvdeyykdavvmdlrvDGGEKWRVVGDMWGeeerPKLGKIVAVDCGKPVFFMLDKDW---ILR 346
Cdd:COG3055 172 ILVIGGRNGS-----------------------GFSNTWTTLAPLPT----ARAGHAAAVLGGKILVFGGESGFsdeVEA 224

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22328264 347 YEMGLNRWRKESSVPKKAHYDKPVGfvaLNGELHV 381
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAVL---TDGKVYV 256
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 38-82 1.48e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22152:

Pssm-ID: 459239  Cd Length: 45  Bit Score: 44.87  E-value: 1.48e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 22328264  38 LIPGLSNDVGRLILSFVPYPHISRIKSTCKSWYAFLSSKTLISLR 82
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
110-381 7.01e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 7.01e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 110 FLFDPVTLSWRSLPLMPcNPHVYGlcnFVAVALGPYVYVLGGsafdtRSYPLDVPLPTSSVFRYSFVKSVWERLSPMMSP 189
Cdd:COG3055  41 EVYDPATNTWSELAPLP-GPPRHH---AAAVAQDGKLYVFGG-----FTGANPSSTPLNDVYVYDPATNTWTKLAPMPTP 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 190 RGSFACAAMPgscGRIIVAGGGSrhtlfgaAGSRMSSVEMYDVEKDEWRVMNELPRFRAGCVGFLVenekekekeeEGRE 269
Cdd:COG3055 112 RGGATALLLD---GKIYVVGGWD-------DGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVL----------PDGK 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 270 FWVMGGYGGSrtvsgilpvdeyykdavvmdlrvDGGEKWRVVGDMWGeeerPKLGKIVAVDCGKPVFFMLDKDW---ILR 346
Cdd:COG3055 172 ILVIGGRNGS-----------------------GFSNTWTTLAPLPT----ARAGHAAAVLGGKILVFGGESGFsdeVEA 224

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22328264 347 YEMGLNRWRKESSVPKKAHYDKPVGfvaLNGELHV 381
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAVL---TDGKVYV 256
PHA03098 PHA03098
kelch-like protein; Provisional
 57-249 4.93e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 52.08  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264   57 PHISRIKSTCKSWYAFLSSKTL---------ISLRHSRDNSNT---NNLSHLLCIFPQDPSISPPFL-FDPVTLSWRSLP 123
Cdd:PHA03098 248 TFGSIIYIHITMSIFTYNYITNysplseintIIDIHYVYCFGSvvlNNVIYFIGGMNKNNLSVNSVVsYDTKTKSWNKVP 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264  124 LMpcnphVYGLCNFVAVALGPYVYVLGGSAFDTrsypldvplPTSSVFRYSFVKSVWERLSPMMSPRGSfACAAMPGscG 203
Cdd:PHA03098 328 EL-----IYPRKNPGVTVFNNRIYVIGGIYNSI---------SLNTVESWKPGESKWREEPPLIFPRYN-PCVVNVN--N 390

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 22328264  204 RIIVAGGGSRHtlfgaaGSRMSSVEMYDVEKDEWRVMNELPRFRAG 249
Cdd:PHA03098 391 LIYVIGGISKN------DELLKTVECFSLNTNKWSKGSPLPISHYG 430
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 38-82 1.48e-06

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 44.87  E-value: 1.48e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 22328264  38 LIPGLSNDVGRLILSFVPYPHISRIKSTCKSWYAFLSSKTLISLR 82
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 135-187 2.48e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 2.48e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 22328264   135 CNFVAVALGPYVYVLGGSAFDTrsypldvplPTSSVFRYSFVKSVWERLSPMM 187
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQ---------SLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
204-250 3.02e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.00  E-value: 3.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 22328264    204 RIIVAGGGSRhtlfgaaGSRMSSVEMYDVEKDEWRVMNELPRFRAGC 250
Cdd:smart00612   1 KIYVVGGFDG-------GQRLKSVEVYDPETNKWTPLPSMPTPRSGH 40
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
110-381 7.01e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 7.01e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 110 FLFDPVTLSWRSLPLMPcNPHVYGlcnFVAVALGPYVYVLGGsafdtRSYPLDVPLPTSSVFRYSFVKSVWERLSPMMSP 189
Cdd:COG3055  41 EVYDPATNTWSELAPLP-GPPRHH---AAAVAQDGKLYVFGG-----FTGANPSSTPLNDVYVYDPATNTWTKLAPMPTP 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 190 RGSFACAAMPgscGRIIVAGGGSrhtlfgaAGSRMSSVEMYDVEKDEWRVMNELPRFRAGCVGFLVenekekekeeEGRE 269
Cdd:COG3055 112 RGGATALLLD---GKIYVVGGWD-------DGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVL----------PDGK 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264 270 FWVMGGYGGSrtvsgilpvdeyykdavvmdlrvDGGEKWRVVGDMWGeeerPKLGKIVAVDCGKPVFFMLDKDW---ILR 346
Cdd:COG3055 172 ILVIGGRNGS-----------------------GFSNTWTTLAPLPT----ARAGHAAAVLGGKILVFGGESGFsdeVEA 224

                       250       260       270
                ....*....|....*....|....*....|....*
gi 22328264 347 YEMGLNRWRKESSVPKKAHYDKPVGfvaLNGELHV 381
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAVL---TDGKVYV 256
PHA03098 PHA03098
kelch-like protein; Provisional
 57-249 4.93e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 52.08  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264   57 PHISRIKSTCKSWYAFLSSKTL---------ISLRHSRDNSNT---NNLSHLLCIFPQDPSISPPFL-FDPVTLSWRSLP 123
Cdd:PHA03098 248 TFGSIIYIHITMSIFTYNYITNysplseintIIDIHYVYCFGSvvlNNVIYFIGGMNKNNLSVNSVVsYDTKTKSWNKVP 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264  124 LMpcnphVYGLCNFVAVALGPYVYVLGGSAFDTrsypldvplPTSSVFRYSFVKSVWERLSPMMSPRGSfACAAMPGscG 203
Cdd:PHA03098 328 EL-----IYPRKNPGVTVFNNRIYVIGGIYNSI---------SLNTVESWKPGESKWREEPPLIFPRYN-PCVVNVN--N 390

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 22328264  204 RIIVAGGGSRHtlfgaaGSRMSSVEMYDVEKDEWRVMNELPRFRAG 249
Cdd:PHA03098 391 LIYVIGGISKN------DELLKTVECFSLNTNKWSKGSPLPISHYG 430
PHA03098 PHA03098
kelch-like protein; Provisional
 112-246 5.98e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 51.69  E-value: 5.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328264  112 FDPVTLSWrslplMPCNPHVYGLCNFVAVALGPYVYVLGGSAFdtrsypLDVPLPTSSVFRYSFVKSVWERLSPMMSPRG 191
Cdd:PHA03098 411 FSLNTNKW-----SKGSPLPISHYGGCAIYHDGKIYVIGGISY------IDNIKVYNIVESYNPVTNKWTELSSLNFPRI 479

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 22328264  192 -SFACaampgSCGRIIVAGGGSRHTlfgaagSRMSSVEMYDVEKDEWRVMNELPRF 246
Cdd:PHA03098 480 nASLC-----IFNNKIYVVGGDKYE------YYINEIEVYDDKTNTWTLFCKFPKV 524
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 38-82 1.48e-06

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 44.87  E-value: 1.48e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 22328264  38 LIPGLSNDVGRLILSFVPYPHISRIKSTCKSWYAFLSSKTLISLR 82
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 135-187 2.48e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 2.48e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 22328264   135 CNFVAVALGPYVYVLGGSAFDTrsypldvplPTSSVFRYSFVKSVWERLSPMM 187
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQ---------SLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
204-250 3.02e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.00  E-value: 3.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 22328264    204 RIIVAGGGSRhtlfgaaGSRMSSVEMYDVEKDEWRVMNELPRFRAGC 250
Cdd:smart00612   1 KIYVVGGFDG-------GQRLKSVEVYDPETNKWTPLPSMPTPRSGH 40
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 189-244 1.56e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 1.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 22328264   189 PRGSFACAAMPGscgRIIVAGGGSRHTlfgaagsRMSSVEMYDVEKDEWRVMNELP 244
Cdd:pfam01344   1 RRSGAGVVVVGG---KIYVIGGFDGNQ-------SLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
146-200 1.59e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 1.59e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 22328264    146 VYVLGGsaFDTRSYpldvplpTSSVFRYSFVKSVWERLSPMMSPRGSFACAAMPG 200
Cdd:smart00612   2 IYVVGG--FDGGQR-------LKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
143-197 2.86e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 2.86e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 22328264   143 GPYVYVLGGSAFDTRSYpldvplpTSSVFRYSFVKSVWERLSPMMSPRGSFACAA 197
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR-------LNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
PHA02713 PHA02713
hypothetical protein; Provisional
 118-183 3.33e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 39.61  E-value: 3.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22328264  118 SWRSLPLMPCNPHVYGLCnfvavALGPYVYVLGGSAFDTRSYP------LDVPLPTSS---VFRYSFVKSVWERL 183
Cdd:PHA02713 378 KWKMLPDMPIALSSYGMC-----VLDQYIYIIGGRTEHIDYTSvhhmnsIDMEEDTHSsnkVIRYDTVNNIWETL 447
Kelch_6 pfam13964
Kelch motif;
135-190 7.04e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 7.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 22328264   135 CNFVAVALGPYVYVLGGSAFDTRsypldvplPTSSVFRYSFVKSVWERLSPMMSPR 190
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGYTNASP--------ALNKLEVYNPLTKSWEELPPLPTPR 50
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 40-76 1.00e-02

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 33.97  E-value: 1.00e-02
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 22328264  40 PGLSNDVGRLILSFVPYPHISRIKSTCKSWYAFLSSK 76
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSP 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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