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Conserved domains on  [gi|42566266|ref|NP_192233|]
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frataxin-like protein [Arabidopsis thaliana]

Protein Classification

frataxin family protein( domain architecture ID 10022430)

frataxin family protein promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways; similar to frataxin, which is a mitochondrial protein that promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways

CATH:  3.30.920.10
EC:  1.16.3.1
Gene Ontology:  GO:0051536|GO:0034986|GO:0004322|GO:0008199|GO:0008198|GO:0016226
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 80-170 2.64e-45

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


:

Pssm-ID: 132463  Cd Length: 97  Bit Score: 144.69  E-value: 2.64e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266    80 EFHKLANFTINHLLEKIEDYGDNVQIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPVSGPSRFDWDRdaNAW 159
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDLDFDVEYSSGVLTLELPSVGTYVINKQPPNKQIWLSSPVSGPKRYDYVN--GEW 78

                          90
                  ....*....|.
gi 42566266   160 IYRRTEAKLHK 170
Cdd:TIGR03422  79 IYLRDGSSLTE 89
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 80-170 2.64e-45

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 144.69  E-value: 2.64e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266    80 EFHKLANFTINHLLEKIEDYGDNVQIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPVSGPSRFDWDRdaNAW 159
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDLDFDVEYSSGVLTLELPSVGTYVINKQPPNKQIWLSSPVSGPKRYDYVN--GEW 78

                          90
                  ....*....|.
gi 42566266   160 IYRRTEAKLHK 170
Cdd:TIGR03422  79 IYLRDGSSLTE 89
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 76-184 2.78e-41

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 134.58  E-value: 2.78e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266    76 LQEEEFHKLANFTINHLLEKIEDYGDNvqIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPVSGPSRFDWDrD 155
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDE--GSDADVEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPISGPFHFDYD-D 77

                          90       100
                  ....*....|....*....|....*....
gi 42566266   156 ANAWIYRRTEAKLHKLLEEELENLCGEPI 184
Cdd:pfam01491  78 AGQWIYTRDGEELFELLSRELSEQLGEPV 106
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 76-186 2.77e-37

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 124.69  E-value: 2.77e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266  76 LQEEEFHKLANFTINHLLEKIEDYGDnvqIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPVsGPSRFDWdrD 155
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDD---DADIDVETQGGVLTLTFGNGSTIVINRQEPLRQIWLASKV-GGYHFDY--K 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 42566266 156 ANAWIYRRTEAKLHKLLEEELENLCGEPIQL 186
Cdd:cd00503  75 NGKWICTRSGEELWELLEEECSAQSGEDVEF 105
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 78-187 6.04e-17

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 72.52  E-value: 6.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266  78 EEEFHKLANftinHLLEKIEDYGDNVQIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPvSGPSRFDWdrDAN 157
Cdd:COG1965   3 ESEFHQLAD----ALLEAIEEALDRDDDADIDCERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAK-SGGFHFDY--DDG 75

                        90       100       110
                ....*....|....*....|....*....|
gi 42566266 158 AWIYRRTEAKLHKLLEEELENLCGEPIQLS 187
Cdd:COG1965  76 KWIDTRSGEELFALLSRALSEQAGEPVTLA 105
cyaY PRK01379
iron donor protein CyaY;
80-150 4.22e-13

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 62.26  E-value: 4.22e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42566266   80 EFHKLANFTINHLLEKIEDYGDNVQIDgfdIDYGNEVLTLKLGSlGTYVLNKQTPNRQIWMSSPVSGPSRF 150
Cdd:PRK01379   5 EFSKIAETTIAYIADKIEEQDKEASID---VDLQGDILNLDTDK-GIYVINKQSAAKEIWLSSPVSGPYHF 71
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 80-170 2.64e-45

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 144.69  E-value: 2.64e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266    80 EFHKLANFTINHLLEKIEDYGDNVQIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPVSGPSRFDWDRdaNAW 159
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDLDFDVEYSSGVLTLELPSVGTYVINKQPPNKQIWLSSPVSGPKRYDYVN--GEW 78

                          90
                  ....*....|.
gi 42566266   160 IYRRTEAKLHK 170
Cdd:TIGR03422  79 IYLRDGSSLTE 89
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 76-184 2.78e-41

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 134.58  E-value: 2.78e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266    76 LQEEEFHKLANFTINHLLEKIEDYGDNvqIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPVSGPSRFDWDrD 155
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDE--GSDADVEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPISGPFHFDYD-D 77

                          90       100
                  ....*....|....*....|....*....
gi 42566266   156 ANAWIYRRTEAKLHKLLEEELENLCGEPI 184
Cdd:pfam01491  78 AGQWIYTRDGEELFELLSRELSEQLGEPV 106
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 76-186 2.77e-37

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 124.69  E-value: 2.77e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266  76 LQEEEFHKLANFTINHLLEKIEDYGDnvqIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPVsGPSRFDWdrD 155
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDD---DADIDVETQGGVLTLTFGNGSTIVINRQEPLRQIWLASKV-GGYHFDY--K 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 42566266 156 ANAWIYRRTEAKLHKLLEEELENLCGEPIQL 186
Cdd:cd00503  75 NGKWICTRSGEELWELLEEECSAQSGEDVEF 105
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 78-186 5.22e-21

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 82.64  E-value: 5.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266    78 EEEFHKLANftinHLLEKIEDYGDNVQIDgFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPvSGPSRFDWdrDAN 157
Cdd:TIGR03421   2 ESEFHQLAE----ALLDAIEEAIDDGDAD-IDCERQGGVLTLTFENGSQIIINKQEPLHQIWLAAK-SGGFHFDY--DGG 73

                          90       100
                  ....*....|....*....|....*....
gi 42566266   158 AWIYRRTEAKLHKLLEEELENLCGEPIQL 186
Cdd:TIGR03421  74 AWIDTRDGEELWALLARACSEQAGEPVVF 102
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 78-187 6.04e-17

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 72.52  E-value: 6.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266  78 EEEFHKLANftinHLLEKIEDYGDNVQIDGFDIDYGNEVLTLKLGSLGTYVLNKQTPNRQIWMSSPvSGPSRFDWdrDAN 157
Cdd:COG1965   3 ESEFHQLAD----ALLEAIEEALDRDDDADIDCERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAK-SGGFHFDY--DDG 75

                        90       100       110
                ....*....|....*....|....*....|
gi 42566266 158 AWIYRRTEAKLHKLLEEELENLCGEPIQLS 187
Cdd:COG1965  76 KWIDTRSGEELFALLSRALSEQAGEPVTLA 105
cyaY PRK01379
iron donor protein CyaY;
80-150 4.22e-13

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 62.26  E-value: 4.22e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42566266   80 EFHKLANFTINHLLEKIEDYGDNVQIDgfdIDYGNEVLTLKLGSlGTYVLNKQTPNRQIWMSSPVSGPSRF 150
Cdd:PRK01379   5 EFSKIAETTIAYIADKIEEQDKEASID---VDLQGDILNLDTDK-GIYVINKQSAAKEIWLSSPVSGPYHF 71
cyaY PRK00446
frataxin-like protein; Provisional
 76-187 4.74e-11

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 56.81  E-value: 4.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42566266   76 LQEEEFHKLANFTINHLLEKIEDYGDnvqidgFDIDYGNE--VLTLKLGSLGTYVLNKQTPNRQIWMSSPVSGpsrFDWD 153
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGD------ADIDCERNggVLTLTFENGSKIIINRQEPLHELWLAAKSGG---FHFD 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 42566266  154 RDANAWIYRRTEAKLHKLLEEELENLCGEPIQLS 187
Cdd:PRK00446  72 YKDGEWICDRSGEEFWALLEEAATQQAGEPVSFR 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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