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Conserved domains on  [gi|15233360|ref|NP_192881|]
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eukaryotic translation initiation factor 3A [Arabidopsis thaliana]

Protein Classification

PCI domain-containing protein( domain architecture ID 10476698)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; similar to Homo sapiens 26S proteasome non-ATPase regulatory subunit 13 and COP9 signalosome complex subunit 3

CATH:  1.25.40.250
Gene Ontology:  GO:0006511
PubMed:  9644972

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00121 super family cl31754
MAEBL; Provisional
 559-841 2.16e-10

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.16  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   559 KEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEE---AEQKRLAAE--LAERRKQRILREIEEKELEEAQ 633
Cdd:PTZ00121 1519 EEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEkkkAEEAKKAEEdkNMALRKAEEAKKAEEARIEEVM 1598

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   634 ALLEETEKRMKKGKkkplldgekvtKQSVKERALTEQLKERQEMEKKLQKLAKTMD----YLERAKREEAAPLIEAAYQR 709
Cdd:PTZ00121 1599 KLYEEEKKMKAEEA-----------KKAEEAKIKAEELKKAEEEKKKVEQLKKKEAeekkKAEELKKAEEENKIKAAEEA 1667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   710 RLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMlgnKEIFQAQVISRRQAEfdRIRTEREERISKIIREKKQERDI 789
Cdd:PTZ00121 1668 KKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKA---EELKKKEAEEKKKAE--ELKKAEEENKIKAEEAKKEAEED 1742

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15233360   790 KRKQiyylkiEEERI-----RKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQR 841
Cdd:PTZ00121 1743 KKKA------EEAKKdeeekKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRR 1793
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 434-509 6.68e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 57.23  E-value: 6.68e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15233360   434 LPEVQLSQYVPSLEKLATLRLLQQVSKIYQTIRIESLSQLVPFFQfSEVEKISVDAVKNNFVAMKVDHMKGVVIFG 509
Cdd:pfam01399  30 LLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEKILAKLIRDGRIRAKIDQVNGIVVFS 104
 
Name Accession Description Interval E-value
PTZ00121 PTZ00121
MAEBL; Provisional
 559-841 2.16e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.16  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   559 KEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEE---AEQKRLAAE--LAERRKQRILREIEEKELEEAQ 633
Cdd:PTZ00121 1519 EEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEkkkAEEAKKAEEdkNMALRKAEEAKKAEEARIEEVM 1598

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   634 ALLEETEKRMKKGKkkplldgekvtKQSVKERALTEQLKERQEMEKKLQKLAKTMD----YLERAKREEAAPLIEAAYQR 709
Cdd:PTZ00121 1599 KLYEEEKKMKAEEA-----------KKAEEAKIKAEELKKAEEEKKKVEQLKKKEAeekkKAEELKKAEEENKIKAAEEA 1667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   710 RLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMlgnKEIFQAQVISRRQAEfdRIRTEREERISKIIREKKQERDI 789
Cdd:PTZ00121 1668 KKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKA---EELKKKEAEEKKKAE--ELKKAEEENKIKAEEAKKEAEED 1742

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15233360   790 KRKQiyylkiEEERI-----RKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQR 841
Cdd:PTZ00121 1743 KKKA------EEAKKdeeekKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRR 1793
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 555-885 4.50e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.80  E-value: 4.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 555 DTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQA 634
Cdd:COG1196 235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 635 LLEETEKRMKKGkkkplldgEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAplIEAAYQRRLVEE 714
Cdd:COG1196 315 EERLEELEEELA--------ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA--ELAEAEEELEEL 384

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 715 REFYEREQQREVELSKERHESDLKEKNRLSRmlgnkeifqaqvISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQI 794
Cdd:COG1196 385 AEELLEALRAAAELAAQLEELEEAEEALLER------------LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 795 YYLKIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQREIELEEKSRREREELLRGTNAPPARLAEPTV 874
Cdd:COG1196 453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                       330
                ....*....|.
gi 15233360 875 TPVGTTAPAAA 885
Cdd:COG1196 533 EAAYEAALEAA 543
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 434-509 6.68e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 57.23  E-value: 6.68e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15233360   434 LPEVQLSQYVPSLEKLATLRLLQQVSKIYQTIRIESLSQLVPFFQfSEVEKISVDAVKNNFVAMKVDHMKGVVIFG 509
Cdd:pfam01399  30 LLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEKILAKLIRDGRIRAKIDQVNGIVVFS 104
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 441-531 1.74e-09

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 55.33  E-value: 1.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    441 QYVPSLEKLATLRLLQQVSKIYQTIRIESLSQLVPFFQfSEVEKISVDAVKNNFVAMKVDHMKGVVIFGnlgiESDGLR- 519
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSV-PEVEKLVSKAIRDGEISAKIDQVNGIVEFE----EVDPRRs 75

                           90
                   ....*....|..
gi 15233360    520 DHLAVFAESLSK 531
Cdd:smart00088  76 EPLAQFAETLKK 87
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 570-845 7.43e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 59.75  E-value: 7.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   570 IIEKRKEDQERQQLEMEREEEQKRLKlqklteeAEQKRLAAELaERRKQRILREIEEKELEEAQALLEETEKRMKKGKKK 649
Cdd:pfam17380 277 IVQHQKAVSERQQQEKFEKMEQERLR-------QEKEEKAREV-ERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERER 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   650 PLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAktmdyLERA-KREEAAPLIEAAYQRRLVE-EREFYEREQQREVE 727
Cdd:pfam17380 349 ELERIRQEERKRELERIRQEEIAMEISRMRELERLQ-----MERQqKNERVRQELEAARKVKILEeERQRKIQQQKVEME 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   728 -LSKERHESDLKEKNRLSRmlgnkeifqaqvisRRQAEFDRIRTEREERISKIIREKKQERDIKRKQIYYLKIEEERIRk 806
Cdd:pfam17380 424 qIRAEQEEARQREVRRLEE--------------ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKR- 488

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 15233360   807 lqeeeearkqEEAERLKKVEAERKANLDKAFEKQRQREI 845
Cdd:pfam17380 489 ----------AEEQRRKILEKELEERKQAMIEEERKRKL 517
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 558-845 9.54e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.15  E-value: 9.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTE------EAEQKRLAAELAE-----RRKQRILREIEE 626
Cdd:TIGR02169  236 ERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKkikdlgEEEQLRVKEKIGEleaeiASLERSIAEKER 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    627 KELEEAQALLEETEKRMKKGKKKPLLDGEkVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAA 706
Cdd:TIGR02169  316 ELEDAEERLAKLEAEIDKLLAEIEELERE-IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKL 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    707 YQrrLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRrQAEFDRIRTEREERISKIIREKKQE 786
Cdd:TIGR02169  395 EK--LKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDK-ALEIKKQEWKLEQLAADLSKYEQEL 471

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 15233360    787 RDIKRKqiyyLKIEEERIRKLqeeeearkqeeAERLKKVEAERKANLDKAFEKQRQREI 845
Cdd:TIGR02169  472 YDLKEE----YDRVEKELSKL-----------QRELAEAEAQARASEERVRGGRAVEEV 515
 
Name Accession Description Interval E-value
PTZ00121 PTZ00121
MAEBL; Provisional
 559-841 2.16e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.16  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   559 KEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEE---AEQKRLAAE--LAERRKQRILREIEEKELEEAQ 633
Cdd:PTZ00121 1519 EEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEkkkAEEAKKAEEdkNMALRKAEEAKKAEEARIEEVM 1598

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   634 ALLEETEKRMKKGKkkplldgekvtKQSVKERALTEQLKERQEMEKKLQKLAKTMD----YLERAKREEAAPLIEAAYQR 709
Cdd:PTZ00121 1599 KLYEEEKKMKAEEA-----------KKAEEAKIKAEELKKAEEEKKKVEQLKKKEAeekkKAEELKKAEEENKIKAAEEA 1667

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   710 RLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMlgnKEIFQAQVISRRQAEfdRIRTEREERISKIIREKKQERDI 789
Cdd:PTZ00121 1668 KKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKA---EELKKKEAEEKKKAE--ELKKAEEENKIKAEEAKKEAEED 1742

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15233360   790 KRKQiyylkiEEERI-----RKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQR 841
Cdd:PTZ00121 1743 KKKA------EEAKKdeeekKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRR 1793
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 555-885 4.50e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.80  E-value: 4.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 555 DTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQA 634
Cdd:COG1196 235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 635 LLEETEKRMKKGkkkplldgEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAplIEAAYQRRLVEE 714
Cdd:COG1196 315 EERLEELEEELA--------ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA--ELAEAEEELEEL 384

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 715 REFYEREQQREVELSKERHESDLKEKNRLSRmlgnkeifqaqvISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQI 794
Cdd:COG1196 385 AEELLEALRAAAELAAQLEELEEAEEALLER------------LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 795 YYLKIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQREIELEEKSRREREELLRGTNAPPARLAEPTV 874
Cdd:COG1196 453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                       330
                ....*....|.
gi 15233360 875 TPVGTTAPAAA 885
Cdd:COG1196 533 EAAYEAALEAA 543
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 434-509 6.68e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 57.23  E-value: 6.68e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15233360   434 LPEVQLSQYVPSLEKLATLRLLQQVSKIYQTIRIESLSQLVPFFQfSEVEKISVDAVKNNFVAMKVDHMKGVVIFG 509
Cdd:pfam01399  30 LLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEKILAKLIRDGRIRAKIDQVNGIVVFS 104
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 558-844 1.56e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 62.26  E-value: 1.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRilreieekeleeAQALLE 637
Cdd:COG1196 224 ELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE------------AQAEEY 291

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 638 ETEKRMKKGKKKplLDGEKVTKQSVKERaLTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLVEEREF 717
Cdd:COG1196 292 ELLAELARLEQD--IARLEERRRELEER-LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALL 368

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 718 YEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQiyyl 797
Cdd:COG1196 369 EAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEAL---- 444

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 15233360 798 kIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQRE 844
Cdd:COG1196 445 -EEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAA 490
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 441-531 1.74e-09

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 55.33  E-value: 1.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    441 QYVPSLEKLATLRLLQQVSKIYQTIRIESLSQLVPFFQfSEVEKISVDAVKNNFVAMKVDHMKGVVIFGnlgiESDGLR- 519
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSV-PEVEKLVSKAIRDGEISAKIDQVNGIVEFE----EVDPRRs 75

                           90
                   ....*....|..
gi 15233360    520 DHLAVFAESLSK 531
Cdd:smart00088  76 EPLAQFAETLKK 87
PTZ00121 PTZ00121
MAEBL; Provisional
 558-845 2.76e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.70  E-value: 2.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRlKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLE 637
Cdd:PTZ00121 1435 EAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAK-KADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD 1513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   638 ETEKRMKKGKKKPLLDGEKVTKQSVKERAltEQLKERQEMEKKLQ-KLAKTMDYLERAKREEA--------APLIEAAYQ 708
Cdd:PTZ00121 1514 EAKKAEEAKKADEAKKAEEAKKADEAKKA--EEKKKADELKKAEElKKAEEKKKAEEAKKAEEdknmalrkAEEAKKAEE 1591

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   709 RRLVEEREFYEREQQREVELSKERHESDLK-EKNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQER 787
Cdd:PTZ00121 1592 ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE 1671

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15233360   788 DIKRKQIYYLKIEEERIRKLQEEEEARKQEEA-ERLKKVEAERKANLDKAFEKQRQREI 845
Cdd:PTZ00121 1672 EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKaEELKKKEAEEKKKAEELKKAEEENKI 1730
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 570-845 7.43e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 59.75  E-value: 7.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   570 IIEKRKEDQERQQLEMEREEEQKRLKlqklteeAEQKRLAAELaERRKQRILREIEEKELEEAQALLEETEKRMKKGKKK 649
Cdd:pfam17380 277 IVQHQKAVSERQQQEKFEKMEQERLR-------QEKEEKAREV-ERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERER 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   650 PLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAktmdyLERA-KREEAAPLIEAAYQRRLVE-EREFYEREQQREVE 727
Cdd:pfam17380 349 ELERIRQEERKRELERIRQEEIAMEISRMRELERLQ-----MERQqKNERVRQELEAARKVKILEeERQRKIQQQKVEME 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   728 -LSKERHESDLKEKNRLSRmlgnkeifqaqvisRRQAEFDRIRTEREERISKIIREKKQERDIKRKQIYYLKIEEERIRk 806
Cdd:pfam17380 424 qIRAEQEEARQREVRRLEE--------------ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKR- 488

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 15233360   807 lqeeeearkqEEAERLKKVEAERKANLDKAFEKQRQREI 845
Cdd:pfam17380 489 ----------AEEQRRKILEKELEERKQAMIEEERKRKL 517
PTZ00121 PTZ00121
MAEBL; Provisional
 567-842 1.74e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 1.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   567 RKSIIEKRKEDQERQQLEMEREEEQKRlKLQKLTEEAEQKRLAAELA----ERRKQRILREIEEKELEEAQALLEETEKR 642
Cdd:PTZ00121 1431 KKADEAKKKAEEAKKADEAKKKAEEAK-KAEEAKKKAEEAKKADEAKkkaeEAKKADEAKKKAEEAKKKADEAKKAAEAK 1509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   643 MKKGKKKPLLDGEKVTK-QSVKERALTEQLKERQEMEKKLQ-------KLAKTMDYLERAKREEA--------APLIEAA 706
Cdd:PTZ00121 1510 KKADEAKKAEEAKKADEaKKAEEAKKADEAKKAEEKKKADElkkaeelKKAEEKKKAEEAKKAEEdknmalrkAEEAKKA 1589

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   707 YQRRLVEEREFYEREQQREVELSKE-----------RHESDLKEKNRLSRMLGNKEIFQAQVIsRRQAEFDRIRTE---- 771
Cdd:PTZ00121 1590 EEARIEEVMKLYEEEKKMKAEEAKKaeeakikaeelKKAEEEKKKVEQLKKKEAEEKKKAEEL-KKAEEENKIKAAeeak 1668

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15233360   772 REERISKIIREKKQERDIKRKQIYYLKIEEERIRKLQE--EEEARKQEEAERLKKVEAERKANLDKAFEKQRQ 842
Cdd:PTZ00121 1669 KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEElkKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEE 1741
PTZ00121 PTZ00121
MAEBL; Provisional
 556-844 7.65e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 56.69  E-value: 7.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   556 TVEKEHKRLLARKSIIEKRKEDQERQQLE--------MEREEEQKRlKLQKLTEEAEQKRLAAEL---AERRKQRILREI 624
Cdd:PTZ00121 1373 KEEAKKKADAAKKKAEEKKKADEAKKKAEedkkkadeLKKAAAAKK-KADEAKKKAEEKKKADEAkkkAEEAKKADEAKK 1451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   625 EEKELEEAQALLEETEKRMKKGKKKPLLD----GEKVTKQSVKERALTEQLKERQEMEKKLQKL-----AKTMDYLERAK 695
Cdd:PTZ00121 1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEeakkADEAKKKAEEAKKKADEAKKAAEAKKKADEAkkaeeAKKADEAKKAE 1531

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   696 REEAAPLIEAAYQRRLVEE----REFYEREQQREVElSKERHESDLKEKNRLSRMLGNKEIFQAQVISRRQAEFDRIRTE 771
Cdd:PTZ00121 1532 EAKKADEAKKAEEKKKADElkkaEELKKAEEKKKAE-EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15233360   772 --REERISKIIREK-KQERDIKRKQIYYLKIEEERIRKlqeEEEARKQEEAERLKKVEAERKANLDKAFEKQRQRE 844
Cdd:PTZ00121 1611 eaKKAEEAKIKAEElKKAEEEKKKVEQLKKKEAEEKKK---AEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKA 1683
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 556-805 1.21e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 55.90  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   556 TVEKEHKRLLArksiieKRKEDQERQQLEmEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQAL 635
Cdd:pfam17380 334 AIYAEQERMAM------ERERELERIRQE-ERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKI 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   636 LEEtEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKER-QEMEKKLQKLAKTMDYLERAKREEAAplieaayQRRLVEE 714
Cdd:pfam17380 407 LEE-ERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERaREMERVRLEEQERQQQVERLRQQEEE-------RKRKKLE 478

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   715 REFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRRQaefDRIRTEREERISKIIREKKQERDIKRK-Q 793
Cdd:pfam17380 479 LEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQ---KAIYEEERRREAEEERRKQQEMEERRRiQ 555

                         250
                  ....*....|..
gi 15233360   794 IYYLKIEEERIR 805
Cdd:pfam17380 556 EQMRKATEERSR 567
PTZ00121 PTZ00121
MAEBL; Provisional
 554-734 5.86e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.99  E-value: 5.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   554 ADTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAElaerrkqriLREIEEKELEEAQ 633
Cdd:PTZ00121 1649 AEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE---------LKKKEAEEKKKAE 1719

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   634 ALLEETEKRMkkgkkkplLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTmdylERAKREEAAPLIEAAYQRRLVE 713
Cdd:PTZ00121 1720 ELKKAEEENK--------IKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE----EEKKAEEIRKEKEAVIEEELDE 1787

                         170       180
                  ....*....|....*....|.
gi 15233360   714 EREFYEREQQREVELSKERHE 734
Cdd:PTZ00121 1788 EDEKRRMEVDKKIKDIFDNFA 1808
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 558-845 9.54e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.15  E-value: 9.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTE------EAEQKRLAAELAE-----RRKQRILREIEE 626
Cdd:TIGR02169  236 ERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKkikdlgEEEQLRVKEKIGEleaeiASLERSIAEKER 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    627 KELEEAQALLEETEKRMKKGKKKPLLDGEkVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAA 706
Cdd:TIGR02169  316 ELEDAEERLAKLEAEIDKLLAEIEELERE-IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKL 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    707 YQrrLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRrQAEFDRIRTEREERISKIIREKKQE 786
Cdd:TIGR02169  395 EK--LKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDK-ALEIKKQEWKLEQLAADLSKYEQEL 471

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 15233360    787 RDIKRKqiyyLKIEEERIRKLqeeeearkqeeAERLKKVEAERKANLDKAFEKQRQREI 845
Cdd:TIGR02169  472 YDLKEE----YDRVEKELSKL-----------QRELAEAEAQARASEERVRGGRAVEEV 515
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 583-864 1.19e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 1.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 583 LEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLEETEKrmkkgkkkplldgekvtKQSV 662
Cdd:COG1196 216 RELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRL-----------------ELEE 278

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 663 KERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLVEEREFYEREQQREVELSKERHESDLKEKNR 742
Cdd:COG1196 279 LELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 743 LSRMLGNKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQIyylKIEEERIRKLQEEEEARKQEEAERL 822
Cdd:COG1196 359 ELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE---ALLERLERLEEELEELEEALAELEE 435

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 15233360 823 KKVEAERKANLDKAFEKQRQREIELEEKSRREREELLRGTNA 864
Cdd:COG1196 436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEA 477
PTZ00121 PTZ00121
MAEBL; Provisional
 526-871 1.22e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   526 AESLSKVRAMLYPVPSKASKLAGVIPNLADTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRlKLQKLTEEAEQ 605
Cdd:PTZ00121 1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK-KADEAKKKAEE 1402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   606 -KRLAAEL----AERRKQRILREIEEKELEEAQALLEETEKRMKKGKKKPLLDGEKV--TKQSVKERALTEQLKERQEME 678
Cdd:PTZ00121 1403 dKKKADELkkaaAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAeeAKKKAEEAKKADEAKKKAEEA 1482

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   679 KKLQKLAKTMDYLERaKREEAAPLIEAayQRRLVEEREFYEREQQREVELSKERHESD----LKEKNRLSRMLGNKEIFQ 754
Cdd:PTZ00121 1483 KKADEAKKKAEEAKK-KADEAKKAAEA--KKKADEAKKAEEAKKADEAKKAEEAKKADeakkAEEKKKADELKKAEELKK 1559

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   755 AQ----VISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQIYYL-------KIEEERIRKLQEEEEARKQEEAERLK 823
Cdd:PTZ00121 1560 AEekkkAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKmkaeeakKAEEAKIKAEELKKAEEEKKKVEQLK 1639

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 15233360   824 KVEAERKAnldKAFEKQRQREIELEEKSRREREELLRGTNAPPARLAE 871
Cdd:PTZ00121 1640 KKEAEEKK---KAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAE 1684
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 562-844 1.66e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.28  E-value: 1.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    562 KRLLARKSIIEKRKEDQERQQLEMEREE--EQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLEET 639
Cdd:pfam02463  727 VQEAQDKINEELKLLKQKIDEEEEEEEKsrLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRAL 806

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    640 EKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLVEEREFYE 719
Cdd:pfam02463  807 EEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKD 886

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    720 REQQREVELSKERHESDLKEKnrlsrmLGNKEIFQAQVISRRQAEfdrIRTEREERISKIIREKKQERDIKRKQIYYLKI 799
Cdd:pfam02463  887 ELESKEEKEKEEKKELEEESQ------KLNLLEEKENEIEERIKE---EAEILLKYEEEPEELLLEEADEKEKEENNKEE 957

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 15233360    800 EEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQRE 844
Cdd:pfam02463  958 EEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEE 1002
PTZ00121 PTZ00121
MAEBL; Provisional
 559-845 1.07e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.75  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   559 KEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLEE 638
Cdd:PTZ00121 1221 EDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEE 1300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   639 TEKRMKKGKKKPlldgEKVTKQSVKERAlTEQLKERQEMEKKLQKlAKTMDYLERAKREEAAPLIEAAYQRRLVEEREFY 718
Cdd:PTZ00121 1301 KKKADEAKKKAE----EAKKADEAKKKA-EEAKKKADAAKKKAEE-AKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKE 1374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   719 ER-----------EQQREVELSKERHESDLKEKNRLSRMLGNK---EIFQAQVISRRQAEFDRIRTE---REERISKIIR 781
Cdd:PTZ00121 1375 EAkkkadaakkkaEEKKKADEAKKKAEEDKKKADELKKAAAAKkkaDEAKKKAEEKKKADEAKKKAEeakKADEAKKKAE 1454

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15233360   782 EKKQERDIKRKQIYYLKIEE-----ERIRK---LQEEEEARKQEEAERLKKVEAERKAN-LDKAFEKQRQREI 845
Cdd:PTZ00121 1455 EAKKAEEAKKKAEEAKKADEakkkaEEAKKadeAKKKAEEAKKKADEAKKAAEAKKKADeAKKAEEAKKADEA 1527
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
508-807 1.98e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 48.50  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360  508 FGNLGIESDGLRDHLAVFAESLSKVRamlypvpSKASKLAGVIPNLADTVEKEHKRLLARK-----------SIIEKRKE 576
Cdd:PRK02224 400 FGDAPVDLGNAEDFLEELREERDELR-------EREAELEATLRTARERVEEAEALLEAGKcpecgqpvegsPHVETIEE 472

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360  577 DQER-QQLEMEREE-EQKRLKLQKLTEEAEQKRLAAELAERRKQRilREIEEKELEEAQALLEE-TEKRMKKGKKKPLLD 653
Cdd:PRK02224 473 DRERvEELEAELEDlEEEVEEVEERLERAEDLVEAEDRIERLEER--REDLEELIAERRETIEEkRERAEELRERAAELE 550

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360  654 GEKVTKQSVKERALTEQLKERQE---MEKKLQKLAKTMDYLERAkrEEAAPLIEaAYQRRLVEEREfyEREQQREVElsK 730
Cdd:PRK02224 551 AEAEEKREAAAEAEEEAEEAREEvaeLNSKLAELKERIESLERI--RTLLAAIA-DAEDEIERLRE--KREALAELN--D 623

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15233360  731 ERHESdLKEKNRLSRMLGNKeiFQAQVISRRQAEFDRIrTEREERISKIIREKKQERDIKRKQIYYLKIEEERIRKL 807
Cdd:PRK02224 624 ERRER-LAEKRERKRELEAE--FDEARIEEAREDKERA-EEYLEQVEEKLDELREERDDLQAEIGAVENELEELEEL 696
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 552-806 2.10e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 48.81  E-value: 2.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    552 NLADTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKR-------LAAELAERRKQRILREI 624
Cdd:pfam02463  765 EKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEqllieqeEKIKEEELEELALELKE 844

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    625 EEKELEEAQALLEETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIE 704
Cdd:pfam02463  845 EQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIK 924

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    705 AAYQRRLVEEREFYEREQQREVELSKErHESDLKEKNRLSRMLGNKEIFQAQVISRRqAEFDRIRTEREERISKIIREKK 784
Cdd:pfam02463  925 EEAEILLKYEEEPEELLLEEADEKEKE-ENNKEEEEERNKRLLLAKEELGKVNLMAI-EEFEEKEERYNKDELEKERLEE 1002

                          250       260
                   ....*....|....*....|..
gi 15233360    785 QERDIKRKQIyylKIEEERIRK 806
Cdd:pfam02463 1003 EKKKLIRAII---EETCQRLKE 1021
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 558-807 3.63e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 3.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRIlrEIEEKELEEAQALLE 637
Cdd:TIGR02168  224 ELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEEL--QKELYALANEISRLE 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    638 ETEKRMKKGKKKPLLDGEKVTKQSVK-ERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLVEERE 716
Cdd:TIGR02168  302 QQKQILRERLANLERQLEELEAQLEElESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQL 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    717 FYEREQQREVELSKERHESDLKE-KNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQIY 795
Cdd:TIGR02168  382 ETLRSKVAQLELQIASLNNEIERlEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEE 461

                          250
                   ....*....|..
gi 15233360    796 YLKIEEERIRKL 807
Cdd:TIGR02168  462 ALEELREELEEA 473
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 558-742 4.21e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.43  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   558 EKEHKRLLARKSI-IEKRKEDQER------QQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRIlreiEEKELE 630
Cdd:pfam17380 408 EEERQRKIQQQKVeMEQIRAEQEEarqrevRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKL----ELEKEK 483

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   631 EAQALLEETEkrmkkgkkkplldgEKVTKQSVKER--ALTEQLKERQEMEKKLQKLAKTMdYLERAKReeaapliEAAYQ 708
Cdd:pfam17380 484 RDRKRAEEQR--------------RKILEKELEERkqAMIEEERKRKLLEKEMEERQKAI-YEEERRR-------EAEEE 541

                         170       180       190
                  ....*....|....*....|....*....|....
gi 15233360   709 RRLVEEREFYEREQQREVELSKERHESDLKEKNR 742
Cdd:pfam17380 542 RRKQQEMEERRRIQEQMRKATEERSRLEAMERER 575
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 558-853 4.90e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 4.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLE 637
Cdd:COG1196 453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 638 ETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEA----AYQRRLVE 713
Cdd:COG1196 533 EAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAvdlvASDLREAD 612

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 714 EREFYEREQQREVELSKERHESDLKEKNRLSRMLGnKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQ 793
Cdd:COG1196 613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLR-EVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEE 691

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 794 IYYLKIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQREIELEEKSRR 853
Cdd:COG1196 692 ELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEE 751
PTZ00121 PTZ00121
MAEBL; Provisional
 552-842 6.49e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 6.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   552 NLADTVEKEHKRLLARKSIIEKRKEDQERQQLE-MEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELE 630
Cdd:PTZ00121 1087 NRADEATEEAFGKAEEAKKTETGKAEEARKAEEaKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKA 1166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   631 EAQALLEETEKRMKKGKKKPLLDGEKVTKQSVKERAlteQLKERQEMEKKLQKLAKTmdylERAKREEAAPLIEAAYQrr 710
Cdd:PTZ00121 1167 EEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKA---EAARKAEEERKAEEARKA----EDAKKAEAVKKAEEAKK-- 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   711 lvEEREFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQERDIK 790
Cdd:PTZ00121 1238 --DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAK 1315

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15233360   791 RKQIYYLKIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQ 842
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAE 1367
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 558-844 1.06e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 46.50  E-value: 1.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREE--EQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQAL 635
Cdd:pfam02463  175 LKKLIEETENLAELIIDLEELKLQELKLKEQAkkALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    636 LEETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLVEER 715
Cdd:pfam02463  255 SSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEK 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    716 EFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRRQA-----EFDRIRTEREERISKIIREKKQERDIK 790
Cdd:pfam02463  335 EEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLEserlsSAAKLKEEELELKSEEEKEAQLLLELA 414

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 15233360    791 RKQIYYLKIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQRE 844
Cdd:pfam02463  415 RQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELK 468
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 559-843 1.61e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 45.73  E-value: 1.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    559 KEHKRLLArksiiEKRKEDQERQQLEMEREEEQK-RLKLQKLTEEAEqkrLAAELAERRKQRILREIEEKELEEAQALLE 637
Cdd:TIGR00618  163 KEKKELLM-----NLFPLDQYTQLALMEFAKKKSlHGKAELLTLRSQ---LLTLCTPCMPDTYHERKQVLEKELKHLREA 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    638 ETEKRMKKGKKKPLLdgEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLVEEREF 717
Cdd:TIGR00618  235 LQQTQQSHAYLTQKR--EAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRI 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    718 YEREQQREVELSKERHESDLKEKNRLSRMLgnkeifQAQVISRRQAEFDRIRTEREERISKiirekkqeRDIKRKQiyyl 797
Cdd:TIGR00618  313 HTELQSKMRSRAKLLMKRAAHVKQQSSIEE------QRRLLQTLHSQEIHIRDAHEVATSI--------REISCQQ---- 374

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 15233360    798 KIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQR 843
Cdd:TIGR00618  375 HTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFR 420
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 571-844 1.64e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    571 IEKRKEDQERQQ------LEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLEETEkrmk 644
Cdd:TIGR02168  198 LERQLKSLERQAekaeryKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELR---- 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    645 kgkkkpLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERaKREEAAPLIEAAYQRRLveerefyerEQQR 724
Cdd:TIGR02168  274 ------LEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLER-QLEELEAQLEELESKLD---------ELAE 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    725 EVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEReeriSKIIREKKQERDIkRKQIYYLKIE---- 800
Cdd:TIGR02168  338 ELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLR----SKVAQLELQIASL-NNEIERLEARlerl 412

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 15233360    801 EERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQRE 844
Cdd:TIGR02168  413 EDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEEL 456
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
557-798 1.82e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360  557 VEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALL 636
Cdd:PRK03918 170 VIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELES 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360  637 EETEKRMKKGKKKPLLDGEKVTKQSVKEraLTEQLKERQEMEKK-----------------LQKLAKTMDYLERAKREEA 699
Cdd:PRK03918 250 LEGSKRKLEEKIRELEERIEELKKEIEE--LEEKVKELKELKEKaeeyiklsefyeeyldeLREIEKRLSRLEEEINGIE 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360  700 APLIEAAYQRRLVEEREFYEREQQREVELSKERHE------SDLKEKNRLSRMLGNKEIfqaQVISRRQAEFDRIRTERE 773
Cdd:PRK03918 328 ERIKELEEKEERLEELKKKLKELEKRLEELEERHElyeeakAKKEELERLKKRLTGLTP---EKLEKELEELEKAKEEIE 404

                        250       260
                 ....*....|....*....|....*...
gi 15233360  774 ERISKIIREK---KQERDIKRKQIYYLK 798
Cdd:PRK03918 405 EEISKITARIgelKKEIKELKKAIEELK 432
PTZ00121 PTZ00121
MAEBL; Provisional
 567-845 2.06e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   567 RKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAE-------------RRKQRILREIEEKELEEAQ 633
Cdd:PTZ00121 1302 KKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKaeaeaaadeaeaaEEKAEAAEKKKEEAKKKAD 1381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   634 ALLEETEKRM--KKGKKKPLLDGEKV--TKQSVKERALTEQLKERQEMEKKLQKLAKTMDylERAKREEAApliEAAYQR 709
Cdd:PTZ00121 1382 AAKKKAEEKKkaDEAKKKAEEDKKKAdeLKKAAAAKKKADEAKKKAEEKKKADEAKKKAE--EAKKADEAK---KKAEEA 1456

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   710 RLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEREERISKIIR--EKKQER 787
Cdd:PTZ00121 1457 KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKkaEEAKKA 1536

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15233360   788 DIKRKQiyylkieeERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQREI 845
Cdd:PTZ00121 1537 DEAKKA--------EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEA 1586
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 564-844 2.38e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 2.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    564 LLARKSIIEKRKEDQErqqlEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLEEtekrm 643
Cdd:TIGR02168  672 ILERRREIEELEEKIE----ELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEV----- 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    644 kkgkkkplldgEKVTKQSVK-ERALTEQLKERQEMEKKLQKLAKTMDYLErAKREEAAPLIEAAyQRRLVEEREFYEREQ 722
Cdd:TIGR02168  743 -----------EQLEERIAQlSKELTELEAEIEELEERLEEAEEELAEAE-AEIEELEAQIEQL-KEELKALREALDELR 809

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    723 QREVELSKERHESDLKEKNRLSRMlgnkeIFQAQVISRRQAEFDRIRtEREERISKIIREKKQERDIKRKQIYYLKIEEE 802
Cdd:TIGR02168  810 AELTLLNEEAANLRERLESLERRI-----AATERRLEDLEEQIEELS-EDIESLAAEIEELEELIEELESELEALLNERA 883

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 15233360    803 RIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQRE 844
Cdd:TIGR02168  884 SLEEALALLRSELEELSEELRELESKRSELRRELEELREKLA 925
PTZ00121 PTZ00121
MAEBL; Provisional
 653-845 4.16e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   653 DGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDY--LERAKREEAAPLIEAAyqRRLVEEREFyerEQQREVELSK 730
Cdd:PTZ00121 1102 EAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDArkAEEARKAEDAKRVEIA--RKAEDARKA---EEARKAEDAK 1176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   731 ERHESDLKEKNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQIYYLKIEEER----IRK 806
Cdd:PTZ00121 1177 KAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERnneeIRK 1256

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 15233360   807 LQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQREI 845
Cdd:PTZ00121 1257 FEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEA 1295
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 555-805 4.39e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 4.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    555 DTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTE-----EAEQKRLAAELAERRKQRIlreieekel 629
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEEriaqlSKELTELEAEIEELEERLE--------- 771

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    630 eEAQALLEETEKRMKKGKKKPLLDGEKVTKQsvkERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQR 709
Cdd:TIGR02168  772 -EAEEELAEAEAEIEELEAQIEQLKEELKAL---REALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    710 RLVEEREFYEREQQREVELSKERHESDLKEKnrlsrmLGNKEIFQAQVISRRQAEFDRIRTEREerISKIIREKKQERDI 789
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESELEAL------LNERASLEEALALLRSELEELSEELRE--LESKRSELRRELEE 919

                          250
                   ....*....|....*.
gi 15233360    790 KRKQIYYLKIEEERIR 805
Cdd:TIGR02168  920 LREKLAQLELRLEGLE 935
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 558-806 4.74e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 44.19  E-value: 4.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    558 EKEHKRLLARKSIIEKRKEDQERQQL-EMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREieekeLEEAQALL 636
Cdd:pfam02463  249 EQEEIESSKQEIEKEEEKLAQVLKENkEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEK-----LKESEKEK 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    637 EETEKRMKKGKKKPLldgEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLV-EER 715
Cdd:pfam02463  324 KKAEKELKKEKEEIE---ELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEElELK 400

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    716 EFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIF----QAQVISRRQAEFDRIRTEREERISKIIREKKQERDIKR 791
Cdd:pfam02463  401 SEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESielkQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLV 480

                          250
                   ....*....|....*
gi 15233360    792 KQIYYLKIEEERIRK 806
Cdd:pfam02463  481 KLQEQLELLLSRQKL 495
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 553-839 5.83e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 43.37  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   553 LADTVEKEHKRLLARKSIIEKRKEDQERQQLEM------EREEEQKRLKLQKLTE-----EAEQKRLAAELAERRKQRIL 621
Cdd:pfam13868  45 LDEMMEEERERALEEEEEKEEERKEERKRYRQEleeqieEREQKRQEEYEEKLQEreqmdEIVERIQEEDQAEAEEKLEK 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   622 REIEEKELEEAQALLEETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQEMEKKlQKLAKTMDYLERAKREEAAp 701
Cdd:pfam13868 125 QRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKE-REIARLRAQQEKAQDEKAE- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   702 lIEAAYQRRLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMLgnKEIFQAQVISRRQAEFDRI--RTEREERISKI 779
Cdd:pfam13868 203 -RDELRAKLYQEEQERKERQKEREEAEKKARQRQELQQAREEQIEL--KERRLAEEAEREEEEFERMlrKQAEDEEIEQE 279

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   780 IREKKQERDIKRKQIYYLKIEEerIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEK 839
Cdd:pfam13868 280 EAEKRRMKRLEHRRELEKQIEE--REEQRAAEREEELEEGERLREEEAERRERIEEERQK 337
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 558-760 6.07e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 43.40  E-value: 6.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQ-KLTEEAEQKRLAAELAERRKQrilreIEEKELEEAQALL 636
Cdd:pfam15709 312 EEERSEEDPSKALLEKREQEKASRDRLRAERAEMRRLEVErKRREQEEQRRLQQEQLERAEK-----MREELELEQQRRF 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   637 EETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQ-EMEKKLQKL--AKTMDYLERA----KREEAAPLIEAAYQR 709
Cdd:pfam15709 387 EEIRLRKQRLEEERQRQEEEERKQRLQLQAAQERARQQQeEFRRKLQELqrKKQQEEAERAeaekQRQKELEMQLAEEQK 466

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15233360   710 RLV----EEREFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISR 760
Cdd:pfam15709 467 RLMemaeEERLEYQRQKQEAEEKARLEAEERRQKEEEAARLALEEAMKQAQEQAR 521
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 558-839 6.16e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 43.81  E-value: 6.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLE 637
Cdd:pfam02463  747 EEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQ 826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    638 ETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLVEEREF 717
Cdd:pfam02463  827 EEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEES 906

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    718 YEREQQREVELSKERHESDLKEKNRLSRMLgNKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQERDIKRKQIYYL 797
Cdd:pfam02463  907 QKLNLLEEKENEIEERIKEEAEILLKYEEE-PEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEE 985

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 15233360    798 KieEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEK 839
Cdd:pfam02463  986 K--EERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLEL 1025
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 553-798 7.06e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 43.81  E-value: 7.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    553 LADTVEKEHKRLLARKSIIEKRK----EDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKE 628
Cdd:pfam02463  266 KLAQVLKENKEEEKEKKLQEEELkllaKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELK 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    629 LEEAQ--ALLEETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKER-QEMEKKLQKLAKTMDYLERAKREEAAPLIEA 705
Cdd:pfam02463  346 ELEIKreAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKeEELELKSEEEKEAQLLLELARQLEDLLKEEK 425

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    706 AYQRRLVEE-REFYEREQQREVELSKERHESDLKE-KNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEREERISKIIREK 783
Cdd:pfam02463  426 KEELEILEEeEESIELKQGKLTEEKEELEKQELKLlKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKA 505

                          250
                   ....*....|....*
gi 15233360    784 KQERDIKRKQIYYLK 798
Cdd:pfam02463  506 RSGLKVLLALIKDGV 520
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 572-807 8.72e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.83  E-value: 8.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 572 EKRKEDQERQQLEMEREEEQKRLKLQKlteeAEQKRLAAELAERRKQRIlreieekeleEAQALLEETEkrmkkgkkkpl 651
Cdd:COG4942  21 AAAEAEAELEQLQQEIAELEKELAALK----KEEKALLKQLAALERRIA----------ALARRIRALE----------- 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 652 ldgEKVTKQSVKERALTEQLKE-RQEMEKKLQKLAKTMDYLERAKREEAAPLIEAAYQRRLVEEREFYEREQQREVELSK 730
Cdd:COG4942  76 ---QELAALEAELAELEKEIAElRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQA 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15233360 731 ERHESDLKEKNRLSRMLGNKEIFQAQVISRRQAEFDRIRTEREERiSKIIREKKQERDIKRKQIYYLKIEEERIRKL 807
Cdd:COG4942 153 EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAER-QKLLARLEKELAELAAELAELQQEAEELEAL 228
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 558-835 9.59e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 42.60  E-value: 9.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRLAAELAERRKQRILREIeekeleeaQALLE 637
Cdd:pfam13868  66 ERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEI--------DEFNE 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   638 ETEKRMKKGKKKPLLDGEKVtKQSVKERALTEQLKERQEMEKKLQK---LAKTMDYLERAKREEAAplIEAAYQRRLVEE 714
Cdd:pfam13868 138 EQAEWKELEKEEEREEDERI-LEYLKEKAEREEEREAEREEIEEEKereIARLRAQQEKAQDEKAE--RDELRAKLYQEE 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   715 REFYEREQQREVELSKERHESDLKEKNRLSRMLgnKEIFQAQVISRRQAEFDRI--RTEREERISKIIREKKQERDIKRK 792
Cdd:pfam13868 215 QERKERQKEREEAEKKARQRQELQQAREEQIEL--KERRLAEEAEREEEEFERMlrKQAEDEEIEQEEAEKRRMKRLEHR 292

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 15233360   793 QIYYLKIEEERIRKLQEEE------EARKQEEAERLKKVEAERKANLDK 835
Cdd:pfam13868 293 RELEKQIEEREEQRAAEREeeleegERLREEEAERRERIEEERQKKLKE 341
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 529-750 1.87e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    529 LSKVRAMLYPVPSKASKLAGVIPNLADTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRL 608
Cdd:TIGR02168  700 LAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE 779

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    609 AAELAERRKQRILREIEEKELEEAQALLEETEKRMKKGKKKPLLDGEKVTKQSV--KERALTEQLKERQEMEKKLQKLAK 686
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIaaTERRLEDLEEQIEELSEDIESLAA 859

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15233360    687 TMDYLERAKREEAAPLIEAAYQRRLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMLGNK 750
Cdd:TIGR02168  860 EIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK 923
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 558-840 2.14e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.96  E-value: 2.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    558 EKEHKRLLARKSIIEKRKEDQErqqlEMEREEEQKRLKLQKLTEEAEQKRLAAELAErrKQRILREIEEKELEEAQALLE 637
Cdd:TIGR00606  781 EESAKVCLTDVTIMERFQMELK----DVERKIAQQAAKLQGSDLDRTVQQVNQEKQE--KQHELDTVVSKIELNRKLIQD 854

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    638 ETEKRMKKGKKKPLLDGEKVTkqsvkeraLTEQLKERQEMEKKLQKLAKTMDYLERA---KREEAAPLieaayqrrlvee 714
Cdd:TIGR00606  855 QQEQIQHLKSKTNELKSEKLQ--------IGTNLQRRQQFEEQLVELSTEVQSLIREikdAKEQDSPL------------ 914

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    715 REFYEREQQREVELSKERHESDLKEKNRLSRM---LGNKEIFQAQVISRRQAEFDRIRTEREERISKIIR-----EKKQE 786
Cdd:TIGR00606  915 ETFLEKDQQEKEELISSKETSNKKAQDKVNDIkekVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAqleecEKHQE 994

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 15233360    787 RDIKRKQIYYLKIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQ 840
Cdd:TIGR00606  995 KINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQ 1048
MAT1 pfam06391
CDK-activating kinase assembly factor MAT1; MAT1 is an assembly/targeting factor for ...
 558-621 4.38e-03

CDK-activating kinase assembly factor MAT1; MAT1 is an assembly/targeting factor for cyclin-dependent kinase-activating kinase (CAK), which interacts with the transcription factor TFIIH. The domain found to the N-terminal side of this domain is a C3HC4 RING finger.


Pssm-ID: 461894 [Multi-domain]  Cd Length: 202  Bit Score: 39.53  E-value: 4.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15233360   558 EKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKRlaaelAERRKQRIL 621
Cdd:pfam06391  74 EKENKDLILKNKMKLSQEEEELEELLELEKREKEERRKEEKQEEEEEKEK-----KEKAKQELI 132
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 538-732 4.59e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   538 PVPSKASKLAGVIPNLADTVEKEHKRLlaRKSIIEKRKEDQERQQlemEREEEQKRLKLQKLTEEAEQKRL--------A 609
Cdd:TIGR02794  29 PEPGGGAEIIQAVLVDPGAVAQQANRI--QQQKKPAAKKEQERQK---KLEQQAEEAEKQRAAEQARQKELeqraaaekA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   610 AELAERRKQRILREIEEKELEEAQALLEETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTM- 688
Cdd:TIGR02794 104 AKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKa 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 15233360   689 DYLERAKREEAAPLIEAAYQRRLVEEREFYEREQQREVELSKER 732
Cdd:TIGR02794 184 EAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAER 227
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 560-842 4.82e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   560 EHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTEEAEQKR-LAAELAERRKQRILReieekeleeAQALLEE 638
Cdd:pfam13868  29 AEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKRYRQeLEEQIEEREQKRQEE---------YEEKLQE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   639 tekrmkkgkkkplldgekvtKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKRE-EAAPLIEAAYQRRLVEEREF 717
Cdd:pfam13868 100 --------------------REQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEqAEWKELEKEEEREEDERILE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   718 YEREQQREVELSKERHESDLKEKNRLSRMLGNkeifQAQVISRRQAEFDRIRT----------EREERISKIIREKKQER 787
Cdd:pfam13868 160 YLKEKAEREEEREAEREEIEEEKEREIARLRA----QQEKAQDEKAERDELRAklyqeeqerkERQKEREEAEKKARQRQ 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 15233360   788 DIKRKQIYYLKIEEERIRKLQEEEEARKQEEAERLKKVEAERKANLDKAFEKQRQ 842
Cdd:pfam13868 236 ELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLE 290
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 518-792 5.61e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 5.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    518 LRDHLAVFAESLSKVRAMLYPVPSKASKLAGVIPNLADTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQ 597
Cdd:TIGR02169  672 EPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    598 KLTE-EAEQKRLAAELAERRKQ---------RILREIEEKELEEAQALLEETEkrmkkgkkkplldgekvtkqsvKERAl 667
Cdd:TIGR02169  752 EIENvKSELKELEARIEELEEDlhkleealnDLEARLSHSRIPEIQAELSKLE----------------------EEVS- 808

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360    668 tEQLKERQEMEKKLQKLAKTMDYLERAKREEAAplieaayQRRLVEEREFYEREQQREVELSKERHESDLKEKNRLSRML 747
Cdd:TIGR02169  809 -RIEARLREIEQKLNRLTLEKEYLEKEIQELQE-------QRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDL 880

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 15233360    748 GNKEIFQAQVISRRQAEFDRIRTEREERISKIIREKKQERDIKRK 792
Cdd:TIGR02169  881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAK 925
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 551-764 7.82e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.75  E-value: 7.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 551 PNLADTVEKEHKRLLARKSIIEKRKEDQERQQLEMEREEEQKRLKLQKLTE-----EAEQKRLAAELAE-RRKQRILREI 624
Cdd:COG4942  19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARriralEQELAALEAELAElEKEIAELRAE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 625 EEKELEEAQALLEETEKRMKKGKKKPLLDGEKVTKQSVKERALTEQLKERQEMEKKLQKLAKTMDYLERAKREEAAPLie 704
Cdd:COG4942  99 LEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAEL-- 176

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360 705 AAYQRRLVEEREFYEREQQREVELSKERHESDLKEKNRLSRMLGNKEIFQAQVISRRQAE 764
Cdd:COG4942 177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 524-734 1.00e-02

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 39.60  E-value: 1.00e-02
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   524 VFAESLSKVRAMLYPVPSK-ASKLAGVIP----NLADTVEKEHKRLLARKSIIEKRKEDQERQ---QLEM----EREEEQ 591
Cdd:pfam05262 131 VVTKSLTKENAGLARRYDQwPGKTQIVIPlkknILSGNVSDVDTDSISDKKVVEALREDNEKGvnfRRDMtdlkERESQE 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233360   592 KRLKLQKLTEEAEQKRLAAELAERRKQRILREIEEKELEEAQALLEETEkrmkkgkkkpLLDGEKVTKQSVKERALTEQL 671
Cdd:pfam05262 211 DAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQEAKN----------LPKPADTSSPKEDKQVAENQK 280

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15233360   672 KERQEMEKKLQKLAKTMDYLERAKREEAAPlieaayqrrlvEEREFYEREQQREVELSKERHE 734
Cdd:pfam05262 281 REIEKAQIEIKKNDEEALKAKDHKAFDLKQ-----------ESKASEKEAEDKELEAQKKREP 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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