|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
30-521 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 665.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 30 RYAILFITFIAYACYHASRKPSSIVKSVLHPDSSTKPPQEHNsdkiypwpmgnvfvkreigdideVLLHRKSKGWEPFNG 109
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPPNI-----------------------VLNNTTWCGWAPFDG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 110 KDGTSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGYFWNIHAFWFFLVMQMAAGLFQATG 189
Cdd:cd17344 58 KNGTELLGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 190 WPSVVAVVGNWFGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGWGWSFIAPGFVMSLGGVLVYLFLAAYPedvgfpd 269
Cdd:cd17344 138 WPSVVACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 270 insnsgkfikrkrdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmiPGVIPFALCLFFSKLVAYTFLY 349
Cdd:cd17344 211 ----------------------------------------------------------PGVIEFSLCLFFAKLVSYTFLY 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 350 WLPFYLSQTTIggeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSYGGVSQTVNIL 429
Cdd:cd17344 233 WLPLYISNTAI----LSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIV 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 430 LMMVAGLFVNGPYALITTAVSADLGTHKSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFLSTLGWQAVFYMLVVGALC 509
Cdd:cd17344 309 LLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAADVC 388
|
490
....*....|..
gi 30684088 510 AGLLLTRLVIAE 521
Cdd:cd17344 389 AGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
30-518 |
1.75e-98 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 303.85 E-value: 1.75e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 30 RYAILFITFIAYACYHASRKPSSIVKS----VLHPDSSTKPPQEHNSDkiypWPMGNVFvkreigdidevllhrkskgwe 105
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPsisaEWTPSNSNTSIELHEET----WNANPLF--------------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 106 pFNGKDGTSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGM----GYFWNIhafWFFLVMQMA 181
Cdd:cd17342 56 -PSQDDAALFLGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVltewLHFYNK---YLYCILWVL 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 182 AGLFQATGWPSVVAVVGNWFGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGWGWSFIAPGFVMSLGGVLVYLFLAAY 261
Cdd:cd17342 132 NGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 262 PedvgfpdinsnsgkfikrkrdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmiPGVIPFALCLFFSK 341
Cdd:cd17342 212 P-----------------------------------------------------------------PGVIPYSLAYACLK 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 342 LVAYTFLYWLPFYLSQttigGEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYhSYGG 421
Cdd:cd17342 227 LVNYSFFFWLPFYLSN----NFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVY-SHSP 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 422 VSQTVNILLMMVAGLFVNGPYALITTAVSADLGTHKSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFL-STLGWQAVF 500
Cdd:cd17342 302 SDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIqNRLGWMWVF 381
|
490
....*....|....*...
gi 30684088 501 YMLVVGALCAGLLLTRLV 518
Cdd:cd17342 382 YFFIIMTILTIVCILPLL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-518 |
5.51e-71 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 231.39 E-value: 5.51e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 30 RYAILFITFIAYACYHASRKPSSIVKSVLHpdsstkppqehnsdkiypwpmgnvfvkrEIGDIDEvllhrkskgwepfng 109
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIV----------------------------EEIGLSK--------------- 37
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 110 kdgtSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGyfwniHAFWFFLVMQMAAGLFQATG 189
Cdd:cd17312 38 ----DDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMG 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 190 WPSVVAVVGNWFGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLAAYPedvgfp 268
Cdd:cd17312 109 WPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASyYGWRAAFLVPGIVGLVVAIILFFFLRDSP------ 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 269 dinsnsgkfikrkrdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmiPGVIPFALCLFFSKLVAYTFL 348
Cdd:cd17312 183 -----------------------------------------------------------PYVWVLSLAYAFVYIVRYACL 203
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 349 YWLPFYLSQTtiggEYVSVKTAGNLSTLFDVGGIVGGILCGYISDK-FKARATTAAAFMYAAIPAMLVYHSYGGVSQTVN 427
Cdd:cd17312 204 DWGPLYLYEV----KGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKlFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLS 279
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 428 ILLMMVAGLFVNGPYALITTAVSADLGTHKslqgdsrALATVTAIIDGTGSAGAALGPLLTGFLS-TLGWQAVFYMLVVG 506
Cdd:cd17312 280 IVLLFLIGFFVGGPINLIGGAAAQDIGRKE-------AAGTATGFVGLFGYLGASLAGLPLGYIIdHYGWSTVFYFLISA 352
|
490
....*....|..
gi 30684088 507 ALCAGLLLTRLV 518
Cdd:cd17312 353 ALLSVLLLLSLW 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
122-518 |
3.28e-37 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 141.16 E-value: 3.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMgyfwnIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:COG2271 53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLAaypedvgfpdinsnsgkfikr 280
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAaFGWRAAFLILGLPGLLLALLRFWLLA--------------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 281 krdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmipgvipfaLCLFFSKLVAYTFLYWLPFYLsQTTI 360
Cdd:COG2271 187 ------------------------------------------------------LAYFLVYFALYGFLTWLPTYL-VEVR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 361 GgeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSYGGvSQTVNILLMMVAGLFVNG 440
Cdd:COG2271 212 G---LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684088 441 PYALITTAVSADLGTHkslqgdsrALATVTAIIDGTGSAGAALGPLLTGFL-STLGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:COG2271 288 AFGLLWALAAELFPKK--------ARGTASGLVNTFGFLGGALGPLLVGYLlDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
113-514 |
4.10e-33 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 130.82 E-value: 4.10e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 113 TSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVglFGMGYF-WNIHAFWFFLVMQMAAGLFQATGWP 191
Cdd:cd17345 37 KTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIIN--ILIGFVpSATSSVGLMFILLFLNGWFQGMGWP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 192 SVVAVVGNWFGKRKRGLIMGIWN-AHTSVGNICGSLIAAGVLEYG---WGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGF 267
Cdd:cd17345 115 PSGRTMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 268 PDINSNSGKFIKRKRDVEEEEEEVEEDLgtdvegdgegssGSGSGYENKrsvgLLQACMIPGVipfalclfFSKLVAYTF 347
Cdd:cd17345 195 PPIEEYKGDYPEEADGEEEEQELSAWEI------------FVKYVLKNK----LLWYIAIANV--------FVYLVRYGI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 348 LYWLPFYLSQTtiggEYVSVKTAGNLSTLFDVGGIVGGILCGYISDK-FKA-RATTAAAFMYAAIPAMLVYhsYGGVSQT 425
Cdd:cd17345 251 LDWAPTYLSEV----KGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKlFKGrRAPTGIIFMILVIVALIVY--WLAPNVL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 426 VNILLMMVAGLFVNGPYALIttAVSADLGTHKSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFlstlGWQAVFYMLVV 505
Cdd:cd17345 325 VDLIALIALGFLIYGPVMLI--GLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHF----GWNGGFIVLLA 398
|
....*....
gi 30684088 506 GALCAGLLL 514
Cdd:cd17345 399 SCILAIIFL 407
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
116-500 |
3.03e-32 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 127.49 E-value: 3.03e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 116 LGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFG-MGYFWNIHAFWFFLvmqmaaGLFQATGWPSVV 194
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGfSTSLWVMAALWALN------GIFQGMGWPPCG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 195 AVVGNWFGKRKRGLIMGIWN-AHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPDINs 272
Cdd:TIGR00881 106 RTVTKWFSRSERGTWVSFWNcSHNVGGGLLPPLVLFGIAElYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAE- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 273 nsgkfikrkrdveeeeeeveedlgtDVEGDGEGSSGSGSGYENKRSVGLLQACMI-PGVIPFALCLFFSKLVAYTFLYWL 351
Cdd:TIGR00881 185 -------------------------EMPNEEPDGDAEKKEEELTKKQIFLQYVLLnKVLWYISLGYVFVYVVRTGILDWS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 352 PFYLSQTtiggEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKF--KARATTAAAFMYAAIPAMLVYHSYGGVSQTVNIL 429
Cdd:TIGR00881 240 PLYLTQE----KGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLI 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30684088 430 LMMVAGLFVNGPYALIttavsadlGTHKSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFLSTL-GWQAVF 500
Cdd:TIGR00881 316 CLFALGFLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGfGWAGAF 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
122-517 |
8.85e-30 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 119.98 E-value: 8.85e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMgyfwnIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEY-GWGWSFIAPGFVMSLGGVLVYLFLaaypedvgfpdinsnsgkfikr 280
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 281 krdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmiPGVIPFALCLFFSKLVAYTFLYWLPFYLSQTTI 360
Cdd:cd17319 179 -----------------------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 361 ggeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKF---KARATTAAAFMYAAIPAMLVYHSYggvSQTVNILLMMVAGLF 437
Cdd:cd17319 212 ----FSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTT---SPVVAVILLSLAGFG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 438 VNGPYALITTaVSADLgthkslqGDSRALATVTAIIDGTGSAGAALGPLLTGFL--STLGWQAVFYMLVVGALCAGLLLT 515
Cdd:cd17319 285 IGAASPVFWS-LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLIGYLvdATGSYTAAFLFLAAVALLAALLVL 356
|
..
gi 30684088 516 RL 517
Cdd:cd17319 357 LL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
122-525 |
7.98e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 106.50 E-value: 7.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGffVGLFGMGYFwniHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:COG2223 48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG--IGLLLLALA---VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPdinsnsgkfikr 280
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA------------ 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 281 krdveeeeeeveedlgtdvegdgegssgsgsgyENKRSVGLLQACMIPGVIPFALCLFFSKLVAYTFLYWLPFYLsQTTI 360
Cdd:COG2223 191 ---------------------------------AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYL-VDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 361 GgeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVyhSYGGVSQTVNILLMMVAGLFVNG 440
Cdd:COG2223 237 G---LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 441 PYALITTAVSADLGThkslqgdsRALATVTAIIDGTGSAGAALGPLLTGFL--STLGWQAVFYMLVVGALcAGLLLTRLV 518
Cdd:COG2223 312 GNGAVFALVPDIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGALldATGSYTAAFLVFAVLAL-VALVLTLLL 382
|
....*..
gi 30684088 519 IAEIREK 525
Cdd:COG2223 383 YRRPRRA 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
116-485 |
3.78e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.57 E-value: 3.78e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 116 LGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMgyfwnIHAFWFFLVMQMAAGLFQATGWPSVVA 195
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 196 VVGNWFGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYlflaaypedvgFPDINSNS 274
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLL-----------LPRPPPES 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 275 GKFIKRKRdveeeeeeveedlgtdvegdgegssgsgsgyENKRSVGLLQACMIPGVIPFALCLFFSKLVAYTFLYWLPFY 354
Cdd:pfam07690 178 KRPKPAEE-------------------------------ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 355 lsQTTIGgeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSYGGVSQTVNILLMMVA 434
Cdd:pfam07690 227 --QEVLG---LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 30684088 435 GLFVNGPYALITTAVSADLGTHKSlqgdsralATVTAIIDGTGSAGAALGP 485
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLAPKEER--------GTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
122-518 |
1.42e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 90.71 E-value: 1.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGyfwniHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:cd17325 39 AYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMALIADIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLaayPEDVGFPDINSNSGKFIKR 280
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLL---PEPRPPPNKRAVSAARLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 281 KRDVEEEEeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmiPGVIPFALCLFFSKLVAYTFLYWLPFYLSQTti 360
Cdd:cd17325 191 GLRLLLRD---------------------------------------RRLLALFLAIFVLAFAFGALEPFLPLYAAEL-- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 361 GGeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKAR--ATTAAAFMYAAIPAMLVYHSYGGVsqtvnILLMMVAGLFv 438
Cdd:cd17325 230 GG--LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKplILIGLLLSAVALLLLPLATSFWLL-----LLLLALLGLG- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 439 ngpYALITTAVSADLgthkSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFLS-TLGWQAVFYMLVVGALCAGLLLTRL 517
Cdd:cd17325 302 ---LGLVFPATLALL----ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLLAAVLFLLL 374
|
.
gi 30684088 518 V 518
Cdd:cd17325 375 R 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
122-479 |
1.50e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.95 E-value: 1.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFWNihaFWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLL--FALGSLLCALAPS---LWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEY-GWGWSFIAPGFVMSLGGVLVYLFLaayPEDVGFPDinsnsgkfikr 280
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRLL---PESRPAAR----------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 281 krdveeeeeeveedlgtdvegdgegssgsgsgyeNKRSVGLLQACMIPGVIPFALCLFFSKLVAYTFLYWLPFYLSQTTi 360
Cdd:COG2814 194 ----------------------------------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 361 ggeYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSYGGVsqtVNILLMMVAGLFVNG 440
Cdd:COG2814 239 ---GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLW---LLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|....*....
gi 30684088 441 PYALITTAVSADLGTHKSlqgdSRALATVTAIIDGTGSA 479
Cdd:COG2814 313 LFPLLQALVAELAPPEAR----GRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
112-514 |
2.25e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.10 E-value: 2.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 112 GTSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIgsgffVGLFGMGYFWNIHAFWFFLVMQMAAGLFQATGWP 191
Cdd:cd06174 29 SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLL-----LFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 192 SVVAVVGNWFGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGwGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPDIN 271
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-GFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 272 SNSGKFIKRKRDVEEEEEeveedlgtdvegdgegssgsgsgyenkrsvgllqacMIPGVIPFALCLFFSKLVAYTFLYWL 351
Cdd:cd06174 183 KNEEASSKSVLKLLKRVL------------------------------------KNPGLWLLLLAIFLVNLAYYSFSTLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 352 PFYLSQTTiggeYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMyaAIPAMLVYHSYGGVSQTVNILLM 431
Cdd:cd06174 227 PLFLLDLG----GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL--LLMALGLALLLLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 432 MVAGLFVNGPYALITTAVsadlgthkSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFLS--TLGWQAVFYMLVVGALC 509
Cdd:cd06174 301 LLLGFGLGGLLPLSFALI--------AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaaTFGLTGAFLVLAVLLLL 372
|
....*
gi 30684088 510 AGLLL 514
Cdd:cd06174 373 AAILL 377
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
113-523 |
1.45e-17 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 85.48 E-value: 1.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 113 TSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGYFWNIHAFWFFLVMQMAAGLFQATGWPS 192
Cdd:PRK09556 63 TTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPC 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 193 VVAVVGNWFGKRKRGLIMGIWNAHTSVGnicgSLIAAGVLEYGW--------GWSFIAPGFVMSLGGVLVYLFLAAYPED 264
Cdd:PRK09556 143 SYSTITRWTPRRKRGRFLGFWNISHNLG----GAGAGGVALWGAnyffdghvIGMFIFPSIIALIIGFIGLRYGSDSPEE 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 265 VGFPDINSNSGKFIKRKrdveeeeeeveeDLGTDVEGDGEGSSGSGSGYENKrsvgllqacmipgVIpFALClffsklVA 344
Cdd:PRK09556 219 LGWGKAEEIFGEPISEE------------DKETESTDMTKWQIFVEYVLKNP-------------VI-WLLC------FA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 345 YTFLY--------WLPFYLSQTTiggeYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVY 416
Cdd:PRK09556 267 NIFLYivrigidnWSPVYAFQEL----GFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRRALVACIALALIIFTLGV 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 417 HSYgGVSQTVNILLMMVAGLFVNGPYALI------------TTAVSADLGTHKSLQGDSRALATVTAIIDGTGSAGAALG 484
Cdd:PRK09556 343 YQH-ATSEYMYLASLFALGFLVFGPQLLIgvaavgfvpkkaIGVANGIKGTFAYLFGDSFAKVGLGMIADPTKNGTPIFG 421
|
410 420 430
....*....|....*....|....*....|....*....
gi 30684088 485 PLLTgflstlGWQAVFYMLVVGALCAGLLLTRLVIAEIR 523
Cdd:PRK09556 422 YTLT------GWAGTFAALDIAAIGCICLMAIVAVMEER 454
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
135-514 |
2.19e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 77.60 E-value: 2.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 135 GHLGDSLDLRLFLTWGMIGSGFFVGLFGMgyfwnIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWFGKRkRGLIMGIWN 214
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGF-----APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 215 AHTSVGNICGSLIAAGVLEYGWG---WSFIAPGFVMSLggvlvYLFLAAYPEDVGFPDINSNSGKFIKRKRDveeeeeev 291
Cdd:cd17478 126 VGGNLGFALGPLIAAALVALFGGlglLILLIIPGLAVA-----LLLLRLRPLKKPEAKKAAAKSSARSTLKG-------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 292 eedlgtdvegdgegssgsgsgyeNKRSVGLLqacmipGVIPFALCLFFSKLVAYtflywLPFYLSQttiggEYVSVKTAG 371
Cdd:cd17478 193 -----------------------VWRALLLL------LIIVFLRSWVLSSLTTF-----LPFYLVQ-----RGYSLVFAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 372 NLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSYGGVSqtvnILLMMVAGLFVNGPYALITTAVSA 451
Cdd:cd17478 234 LLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWS----YILLVLAGFLLFASFPVTVVLAQE 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684088 452 DLGTHKSLqgdsralatVTAIIDGTGSAGAALGPLLTGFLS-TLGWQAVFYMLVVGALCAGLLL 514
Cdd:cd17478 310 LLPGNVGL---------ASGLMMGLSFGLGGIGAPVLGALAdAFGLESVLLILALLPLLGALLA 364
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
113-491 |
2.57e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 77.78 E-value: 2.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 113 TSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLfgMGYFWNihaFWFFLVMQMAAGLFQATGWPS 192
Cdd:TIGR00895 51 PVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATN---VTQLLILRFLAGLGLGGLMPN 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 193 VVAVVGNWFGKRKRGLIMGIWNAHTSVGNICGSLIAAGVL-EYGWGWSFIAPGFVMSLGGVLVYLFLaayPEdvgfpdin 271
Cdd:TIGR00895 126 LNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFL---PE-------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 272 snSGKFIKRKRDVEEEEEEVEEDlGTDVEGDGEGSSGSGSGYENKRSV--GLLQACMIPGVIPFALCLFFSKLVAYTFLY 349
Cdd:TIGR00895 195 --SIDFLVSKRPETVRRIVNAIA-PQMQAEAQSALPEQKSTQGTKRSVfkALFQGKTARITVLLWLLYFMLLVGVYFLTN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 350 WLPFYLSQTTiggeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARaTTAAAFMYAAIPAMLVYHSYGgvSQTVNIL 429
Cdd:TIGR00895 272 WLPKLMVELG-----FSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-VTALLLLLGAVFAVLVGSTLF--SPTLLLL 343
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30684088 430 LMMVAGLFVNGPYALITTAvsadlgTHKSLQGDSRALATVTAIidGTGSAGAALGPLLTGFL 491
Cdd:TIGR00895 344 LGAIAGFFVNGGQSGLYAL------MALFYPTAIRATGVGWAI--GIGRLGAIIGPILAGYL 397
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
106-525 |
2.61e-15 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 78.21 E-value: 2.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 106 PFNGKDGTSRlGEIDVAFLA---CYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGYfWNIHAFWFFLVMQMAA 182
Cdd:PRK11273 53 PYLVEQGFSR-GDLGFALSGisiAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVP-WATSSIAVMFVLLFLC 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 183 GLFQATGWPSVVAVVGNWFGKRKRGLIMGIWN-AHTSVGNICGSLIAAGVLEYG-WGWSFIAPGFVMSLGGVLVYLFLAA 260
Cdd:PRK11273 131 GWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNcAHNVGGGLPPLLFLLGMAWFNdWHAALYMPAFAAILVALFAFAMMRD 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 261 YPEDVGFPDINsnsgkfiKRKRDVEEEEEEVEEDLGTdvegdgEGSSGSGSGYENKrsvgLLQACMIPGVipfalclfFS 340
Cdd:PRK11273 211 TPQSCGLPPIE-------EYKNDYPDDYNEKHEQELT------AKQIFMQYVLPNK----LLWYIAIANV--------FV 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 341 KLVAYTFLYWLPFYLSQTtiggEYVSVKTAGNLSTLFDVGGIVGGILCGYISDK-FKA-RATTAAAFMYAAIPAMLVYHS 418
Cdd:PRK11273 266 YLLRYGILDWSPTYLKEV----KHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKvFRGnRGATGVFFMTLVTIATIVYWL 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 419 YGGVSQTVNILLMMVAGLFVNGPYALIttavsadlGTH------KSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFls 492
Cdd:PRK11273 342 NPAGNPTVDMACMIVIGFLIYGPVMLI--------GLHalelapKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFF-- 411
|
410 420 430
....*....|....*....|....*....|...
gi 30684088 493 tlGWQAVFYMLVVGALCAGLLLTRLVIAEIREK 525
Cdd:PRK11273 412 --GWDGGFMVMIGGSILAVILLIVVMIGEKRHH 442
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
124-524 |
1.41e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 75.68 E-value: 1.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 124 LACYSIGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFwniHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWFGK 203
Cdd:COG2807 63 LLAFGLFAPLAPRLARRFGLERTLLLALLL--LAAGLLLRSLA---PSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 204 RkRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPDINSNSGKFIKRKR 282
Cdd:COG2807 138 R-VGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPL 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 283 dveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmipgVIPFALCLFFSKLVAYTFLYWLPFYLSQttIGg 362
Cdd:COG2807 217 -----------------------------------------------AWLLTLFFGLQSLLYYAVVAWLPPILRD--AG- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 363 eyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAF--MYAAIPAMLVYhsyggVSQTVNILLMMVAGLFVNG 440
Cdd:COG2807 247 --LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLglLGLAGLLGLLL-----APGSLPWLWAVLLGLGQGG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 441 PYALITTAVSADLGTHkslqgdsRALATVTAIIDGTGSAGAALGPLLTGFL--STLGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:COG2807 320 LFPLALTLIGLRARTP-------AEAAALSGMAQSVGYLLAALGPLLVGALhdATGSWTAALLLLAALAVLMLVAGLLAG 392
|
....*.
gi 30684088 519 IAEIRE 524
Cdd:COG2807 393 RPYVED 398
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
114-514 |
2.03e-14 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 75.06 E-value: 2.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 114 SRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGmgYF---WNIHAFWFFlvmqmaAGLFQATGW 190
Cdd:cd17343 38 SDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS--GSssvWVFSILWFL------NGLAQGLGW 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 191 PSVVAVVGNWFGKRKRGLIMGIWNAHTSV-GNICGSLIAAGVLEYGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPD 269
Cdd:cd17343 110 PPCAKILRKWFSPSQFGTWWSVLSTSMNLaGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNN 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 270 INSNSGkfiKRKRDVEEEEEEVEEDLGTDvegdgegssgsgsgyenkrsvgllqacmiPGVIPFALCLFFSKLVAYTFLY 349
Cdd:cd17343 190 IEEEES---KGKKKKSPRGESTLKELLLS-----------------------------PFLWLLSLGYLVVFGVKTAVTD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 350 WLPFYLSQttigGEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARAT---------TAAAFMYAAIPA---MLVYH 417
Cdd:cd17343 238 WGQLFLIQ----DKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGsssrgnprmPLALVFMAGLTVslhLFRVH 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 418 SYGGVSQTVNILLMMVAGLFVNGPYALIttAVSADLGTHKSLQGDSRALAtvtaiidgtgSAGAALGPLLTGF-LSTL-- 494
Cdd:cd17343 314 ITSDSSELFILLLGFLIGFSLYGPIAIF--GVIANESAPSHLCGTSHAIV----------ALAANVGGVLAGLpFSYIak 381
|
410 420
....*....|....*....|..
gi 30684088 495 --GWQAVFYMLVVGALCAGLLL 514
Cdd:cd17343 382 hyDWRTAFLLLEILCAITVVIL 403
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
114-514 |
5.56e-14 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 73.98 E-value: 5.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 114 SRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGyfwniHAFWFFLVMQMAAGLFQATGWPSV 193
Cdd:PRK11663 58 SDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVC 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 194 VAVVGNWFGKRKRGLIMGIWN-AHTSVGNICGSLIAAGVLEYGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPDINS 272
Cdd:PRK11663 133 AKLLTAWYSRTERGGWWAIWNtAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 273 NSGKFIKRKRDVEEEEEEVEEDLGTDVEgdgegssgsgsgyeNKRSVGLLqacmipgvipfALCLFFSKLVAYTFLYWLP 352
Cdd:PRK11663 213 WRHDALELAQQQEGAGLSRKEILTKYVL--------------LNPYIWLL-----------SFSYVLVYVVRAAINDWGN 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 353 FYLSQTtiggEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKF--KARATTA---AAFMYAAIPAMLVYHSYGGVSQTVn 427
Cdd:PRK11663 268 LYMSET----LGVDLVTANSAVSMFELGGFIGALVAGWGSDKLfnGNRGPMNlifAAGILLSVGSLWLMPFASYVMQAA- 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 428 ilLMMVAGLFVNGPYALITTAvsADLGTHKSLQGdsralaTVTAIIDGTGSAGAAL-GPLLTGFLSTLGWQAVFYMLVVG 506
Cdd:PRK11663 343 --CFFTIGFFVFGPQMLIGMA--AAECSHKEAAG------AATGFVGLFAYLGAALsGYPLAKVLEIWHWTGFFVVISIA 412
|
....*...
gi 30684088 507 ALCAGLLL 514
Cdd:PRK11663 413 AGISALLL 420
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
114-514 |
5.67e-14 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 73.59 E-value: 5.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 114 SRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGyfwniHAFWFFLVMQMAAGLFQATGWPSV 193
Cdd:cd17488 38 SDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS-----SSLWAFAVLWTLNAFFQGWGWPPC 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 194 VAVVGNWFGKRKRGLIMGIWN-AHTSVGNICGSLIAAGVLEYGWGWSFIAPGFVMSLGGVLVYLFLAAYPedvgfpdins 272
Cdd:cd17488 113 ARLLTHWYSRNERGFWWSIWNtSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRP---------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 273 nsgkfikrkrdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmiPGVIPFALCLFFSKLVAYTFLYWLP 352
Cdd:cd17488 183 -------------------------------------------------------PYIWLLAFCYVLVYVVRTAINDWGN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 353 FYLSQTtiggEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKA--RATTAAAF---MYAAIPAM--LVYHSYggvsqT 425
Cdd:cd17488 208 LYLSET----HGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKgnRGPMNLIFalgLLVSVGALwlVPVHSY-----W 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 426 VNILLMMVAGLFVNGPYALIttAVSADLGTHKSLQGdsralaTVTAIIDGTGSAGAAL-GPLLTGFLSTLGWQAVFYMLV 504
Cdd:cd17488 279 LLATCFFTIGFFVFGPQMLI--GMAAAECSHKDAAG------SATGFVGLFAYLGAALaGYPLAKVIESWGWSGFFIVIS 350
|
410
....*....|
gi 30684088 505 VGALCAGLLL 514
Cdd:cd17488 351 IAAAISGLLL 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
122-510 |
1.81e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.81 E-value: 1.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFWNihaFWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:cd17324 42 AYALGYALGALLLGPLSDRIERRRLLLVLLLL--FILGNLLAALAPS---FALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEY-GWGWSFIAPGFVMSLGGVLVYLFLaayPEDVGFPDINSNSGKFIKR 280
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLL---PSLPPKKPGSLGLLSSLLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 281 KRdveeeeeeveedlgtdvegdgegssgsgsgyenkRSVGLLQACMIpgvipfALCLFFSKLVAYTFlywLPFYLSQTTi 360
Cdd:cd17324 194 LL----------------------------------RNPRLRLAYLI------TFLLFGGFFALYTY---LAPFLTDVP- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 361 ggeYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAI-PAMLVYHSYGGVSqtvnILLMMVAGLFVN 439
Cdd:cd17324 230 ---GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAlLLLTLLGPSPLLL----LVGLVLWGLGFF 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30684088 440 GPYALITTAVSadlgthkSLQGDSRALAtvTAIIDGTGSAGAALGPLLTG-FLSTLGWQAVFY----MLVVGALCA 510
Cdd:cd17324 303 AAHSALQTRVL-------RLAPEARGLA--SSLYLAAYNLGGALGAALGGlVLDHGGWAGVGWvgaaLLLLALLLA 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
113-513 |
5.64e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.65 E-value: 5.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 113 TSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFWNihaFWFFL----VMQMAAGLFQAT 188
Cdd:COG0738 42 DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL--MALGLLLFALAPS---YPLLLlalfLLGLGLGLLDVA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 189 GWPSVVAVvgnwfGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGWGWSFIAPGFVMSLGGVLVYLFLAAYPedvgFP 268
Cdd:COG0738 117 ANPYVAAL-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSK----LP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 269 DINSNSGKfikrkrdveeeeeeveedlgtdvegdgegssgsgsgyENKRSVGLLQACMIPGVIPFALCLFFSKLVAYTFL 348
Cdd:COG0738 188 EIEEEEEE-------------------------------------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 349 YWLPFYLSQTTIggeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSYGGVsqtVNI 428
Cdd:COG0738 231 DWLPLYLKDVLG----LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPW---LAL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 429 LLMMVAGLFVNGPYALITTAVSADLGTHKslqgdsralATVTAIIDGTGSAGAALGPLLTGFLS-TLGWQAVFYMLVVGA 507
Cdd:COG0738 304 IGLALVGLGLSLMFPTIFSLALDGLGKRT---------AAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLVPLVCY 374
|
....*.
gi 30684088 508 LCAGLL 513
Cdd:COG0738 375 LLILLL 380
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
129-514 |
6.34e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.23 E-value: 6.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 129 IGMYVAGHLGDSLDLRLFLTWGMigSGFFVGLFGMGYFWNIHAFWFFLVMqmaAGLFQATGWPSVVAVVGNWFGKRKRGL 208
Cdd:cd17365 49 IGALLAGPLADRFGRKRVLLVSV--ALFGLFTLLTAFAQSVLQLALLRFL---TGLGLGAAMPNAITLVSEYAPARRRSL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 209 IMGIWNAHTSVGNICGSLIAAGVLEyGWGWSFiapgfVMSLGGVLvylflaaypedvgfpdinsnsgkfikrkrdveeee 288
Cdd:cd17365 124 AVTLMFCGYPLGAALGGFLAAALIP-AFGWRS-----VFLLGGVP----------------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 289 eeveedlgtdvegdgegssgsgsgyenkrsvGLLQACMIPGVIPFALCLFFSKLVAYTFLYWLPFYLSQTTIggeyvSVK 368
Cdd:cd17365 163 -------------------------------PLILLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGY-----SLS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 369 TAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVyhSYGGVSQTVNILLMMVAGLFVNGPYALITTA 448
Cdd:cd17365 207 QALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALL--GVSPASLVLLYVLVFLAGACVNGAQVGLYAL 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30684088 449 VSADLGTHkslqgdSRALATVTAIidGTGSAGAALGPLLTGFLSTLGWQA--VFYMLVVGALCAGLLL 514
Cdd:cd17365 285 AARFYPTE------VRATGVGWAL--GVGRLGAILGPLLGGLLLAAGLGPesVFLALAIPAALGALAV 344
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
121-485 |
2.08e-11 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 65.73 E-value: 2.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 121 VAFLACYSIGMYVAGHLGDSLDLRLFL-----TWGMIGsgffVGLFGMGYFWNIHAFWFFLvmqmaaGLFQATGWPSVVA 195
Cdd:cd17327 48 TVFYVGYIIFELPGNLLLQRFPPSKWLsvfivLWGLLT----LLTAAVKNFGGLIALRFFL------GLFESGVFPGFIL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 196 VVGNWFGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-------YGWGWSFIAPGFVMSLGGVLVYLFLaaypedvgfP 268
Cdd:cd17327 118 YLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvgglAGWRWLFIIEGLITIIIGLVIFFWL---------P 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 269 DINSNSGKFIKR-KRDVEEEEEEVEEDLGTDvegdgegssgsgsgyENKRSVgLLQACMIPGVIPFALCLFFSKLVAYTF 347
Cdd:cd17327 189 DNPSKAWFLTEEeKELAVERLRANQTGKGDQ---------------KFKWKQ-IKEAFKDPRTWLLFLFFFCSQITNNGI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 348 LYWLPfylsqTTIGGEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARA--TTAAAFMYAAIPAMLVYHSYGGVSQT 425
Cdd:cd17327 253 SNFLP-----LILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGlfAIFACVLALVGSIILLAAPNPPGAYF 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 426 VNILLMMVAGlfvnGPYALITTAVSAdlgthkSLQGDSRAlATVTAIIDGTGSAGAALGP 485
Cdd:cd17327 328 AAYILGGGSY----AGFPILLSWISS------NCAGYTKR-ATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
133-520 |
4.74e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 64.52 E-value: 4.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 133 VAGHLGDSLDLRLFLTWGMigsgFFVGLFGMGYFWnIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWFGKRKRGLIMGI 212
Cdd:cd17473 54 LAGWLADRFGRKRLLIAGL----LLYGIGGVAGLF-LDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 213 WNAHTSVGNICGSLIAAGVLEYGWGWSFiapgFVMSLGGVLVYLFLAAYPEdvgfPDINSNSgkfikrkrdveeeeeeve 292
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAEIGWRAPF----LVYLLALPVLILVLLFLPE----PARKSKS------------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 293 edlgtdvegdgegssgsgsgyENKRSVGLLQACMIPGVIPFALCLFFSKLVAYTFLYWLPFYLSQTTIGGEyvsvKTAGN 372
Cdd:cd17473 183 ---------------------AASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSA----ALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 373 LSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIpamlvyhSYGGVSQTVNILLMMVAGLFVNGPYALITTAVSAD 452
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL-------GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30684088 453 LGTHKSLQGDSRALATVTAIIdgtgSAGAALGPLLTGFLSTLGWQAVFYMLVVGALCAGLLLTRLVIA 520
Cdd:cd17473 311 AMSLVPPELRGRAMGIVTSAF----FLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
112-514 |
9.23e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 63.49 E-value: 9.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 112 GTSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRlfltwGMIGSGFFVGLFGMGYFWNIHAFWFFLVMQ----MAAGLFQA 187
Cdd:cd17333 29 NVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRR-----RTLILGLLLISLALALIFATPSIYLFVVLMflagLGAGILDT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 188 TGWPSVVAVvgnwfGKRKRGLIMGIWNAHTSVGNICGSLIAAGVL--EYGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDV 265
Cdd:cd17333 104 GANTFVGAL-----FEESSATRLNVLHGFFGLGALIGPLIATSLLtsELSWSWAYLIIGLIYLLLAILILLTLFPELPSA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 266 GFPDINSNSGK--FIKRKRdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmIPGVIPFALCLFFSKLV 343
Cdd:cd17333 179 RNPQQSVGAFSasASRLLR--------------------------------------------NPSIILGALALFLYVGA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 344 AYTFLYWLPFYLsqttIGGEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAA-AFMYAAIPAMLVYHSyggv 422
Cdd:cd17333 215 ETAFSSWVPSYL----VEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLsGSGALLGLLILLLAP---- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 423 SQTVNILLMMVAGLFVNGPYALITTAVSADLGTHKSlqgdsralaTVTAIIDGTGSAGAALGPLLTGFL-STLGWQAVFY 501
Cdd:cd17333 287 TLVVGLVATALLGLFMAALFPTILSLGISNLPYAKG---------KGTSVLLAAGSIGGAIIPFIMGFIaEAVGIQTAML 357
|
410
....*....|....
gi 30684088 502 ML-VVGALCAGLLL 514
Cdd:cd17333 358 LItILYAIIFVLAL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
127-514 |
1.34e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.03 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 127 YSIGMYVAGHLGDSLDLRLFLTWGMIGSGffVGLFGMGYFWNI-HAFWFFLVMQMAAGLFQATGWPSVVAvvgnWFGKRK 205
Cdd:cd17475 44 VAVSMLPAGWLLDRFGERRVLAVGLLLMG--AAALLMALVGSYpVLLVLLFLVGAGYGSVQPGGGRAIMR----WFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 206 RGLIMGIWNAHTSVGNICGSLIAAGV-LEYGWGWSFIAPGFVMSLGGVLVYLFLAAYPEdvgfpdinsnsgkfIKRKRDV 284
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILAAVLFWLFYREPPA--------------ASAATES 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 285 EEEEEEVEEDLGTDvegdgegssgsgsgyenkRSVGLLqacmipGVIPFALCLFFSKLVAYTFLYwlpfylSQTTIGgey 364
Cdd:cd17475 184 ASTLLRSLKEVLRN------------------RDVWLI------AIAGALLVAPQFALLTFLLLF------LHDHLG--- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 365 VSVKTAGNLSTLFDVGGIVGGILCGYISDKFKA-------RATTAAAFMYAAIPAMLVYHSYGGVSqtvnILLMMVAGLF 437
Cdd:cd17475 231 LSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrpvlVITAAIAAAALLVLSLLSPGTPLWLL----VLLLILLGLF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684088 438 VNGPYALITTAVSADLGTHKSlqgdsralATVTAIIDGTGSAGAALGPLLTGFL--STLGWQAVFYMLVVGALCAGLLL 514
Cdd:cd17475 307 AIGWNGLYLTLVAESAGPEQA--------GTALGLANTINFIGIAIGPPLFGLLvdATHSYAPAWLALALLLVLAALLL 377
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
122-257 |
2.46e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 61.75 E-value: 2.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFWNIHAFWFFLVMQmaaGLFQATGWPSVVAVVGNWF 201
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL--FGLASLLCGLAPSPELLIAARALQ---GIGAGGLMPGALALIAELF 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEY-GWGWSFIAPGFVMSLGGVLVYLF 257
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
129-514 |
1.43e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.92 E-value: 1.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 129 IGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFWNihaFWFFLVMQMAAGLFQATGWPSVVAVVGNWFGKRKRGL 208
Cdd:cd17316 51 IGALLFGYLGDRIGRKKALILTLLL--FGLATLLIGLLPT---PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 209 IMGIWNAHTSVGNICGSLIAAGV-----LEYGWGWSFiapgFVMSLGGVLVYLFlaaypedvgfpdinsnsgkfikRKRd 283
Cdd:cd17316 126 ALGLLQSGWALGALLAALVASLLipllsGDWGWRILF----LIGALPALLALLL----------------------RRR- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 284 veeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmipgVIPFALCLFFSKLVAYTFLYWLPFYLSQTTIgge 363
Cdd:cd17316 179 ----------------------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLG--- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 364 yVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYhSYGGVSQTVNILLMMVAGLFVNGPYA 443
Cdd:cd17316 210 -LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF-YLLSGSPTLLLLLLFILSFFVGGVWG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30684088 444 LittavsadLGTHKSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFL--STLGWQAVFYMLVVGALCAGLLL 514
Cdd:cd17316 288 A--------LYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLlaSTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
123-514 |
3.17e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 58.85 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 123 FLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGyfwniHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWFG 202
Cdd:cd17371 43 TLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA-----QNYWQLLILRALAGLGFGGEWAAGAALMAEYVP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 203 KRKRGLIMGIWNAHTSVGNICGSLIAAGVL-----EYGWGWSFIApGFVMSLGGVLVYLFLaayPEDVGFPDinsnsgkf 277
Cdd:cd17371 118 ARHRGKALGYVQSGWAVGWLLATLLAALLFpllppEIAWRVLFLL-GALPALLVLFIRRFV---KEPPQWQA-------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 278 iKRKRDVEEEEEEVEEdlgtdvegdgegssgsgsgyenkrsvGLLQACMIPGVIPFALCLFFSKLVAYTFLYWLPFYLSQ 357
Cdd:cd17371 186 -ARAARRHFADRPSLR--------------------------ELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 358 TtiggEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIpAMLVYhSYGGVSQTVNILLMMVAGLF 437
Cdd:cd17371 239 E----RGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAI-SILLY-FFLPLSPTLILILGFPLGFF 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30684088 438 VNGPYALITTAVSADLGThkslqgdsRALATVTAIIDGTGSAGAALGPLLTGFLST-LGWQAVFYMLVVGALCAGLLL 514
Cdd:cd17371 313 ASGPFSGMGAYLTELFPT--------AVRATAQGFCYNVGRIIGALFPFLVGFLATsGSLGTAIAVFAAVYYIAGLVL 382
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
122-514 |
9.68e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 57.28 E-value: 9.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWG-MIGSGFFVGLFGMGYFWNIHAFWFFLVMQMAAGLFqatgwPSVVAVVGNW 200
Cdd:cd17355 46 VGLLAFGLAQPFVGRLLDRFGPRRVMLLGlLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLA-----AVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 201 FGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPDINSNSGKfik 279
Cdd:cd17355 121 WFERRRGLALGILTAGGGLGSLVFLPLGAALIEaFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPA--- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 280 rkrdveeeeeeveedlgtdvegdgegssgsgsgyenKRSVGLLQACMIPG----VIPFALCLF-FSKLVAYTFLYWLPFY 354
Cdd:cd17355 198 ------------------------------------SPGSTLKEALRSASfwllALAFFLCGFaVVGLIVHLVPYLADRG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 355 LSQTtiggeyvsvkTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIpaMLVYHSYGGVSQTVNILLMMVA 434
Cdd:cd17355 242 ISPA----------AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRAL--GLALLLLLPFPPLALLLFAALF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 435 GLFVNGPYALITTAVSADLGThkslqgdsRALATVTAIIDGTGSAGAALGPLLTGFLSTL--GWQAVFYMLVVGALCAGL 512
Cdd:cd17355 310 GLGWGATVPLTAALAARYFGA--------RSYGTLFGLVFAPHQLGSALGPWLGGLLYDRtgSYTAAWALAVALGLIAAL 381
|
..
gi 30684088 513 LL 514
Cdd:cd17355 382 LV 383
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
335-516 |
1.04e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 57.28 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 335 LCLFFSKLVAYTFLYWLPFYLsqttiGGEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAaaFMYAAIPAML 414
Cdd:PRK11551 227 ISYFFTLIVLYFLLNWLPSLL-----VGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVL--LIYAGILASL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 415 VyhsygGVSQTVNILLMMV----AGLFVNGP----YALITTAVSADL-GThkslqGDSRALATvtaiidgtGSAGAALGP 485
Cdd:PRK11551 300 A-----ALAAAPSFAGMLLagfaAGLFVVGGqsvlYALAPLFYPTQVrGT-----GVGAAVAV--------GRLGSMAGP 361
|
170 180 190
....*....|....*....|....*....|....*..
gi 30684088 486 LLTGFLSTLGWQAVFYML------VVGALCAGLLLTR 516
Cdd:PRK11551 362 LLAGQLLALGRSTVGVIGasipviLVAALAALLLVSR 398
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
121-517 |
1.13e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.24 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 121 VAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGYFWNIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNW 200
Cdd:cd06173 41 AAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPEL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 201 FGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPDINSNSGKFIKr 280
Cdd:cd06173 121 VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLRE- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 281 krdveeeeeeveedlgtdvegdgegssgsgSGYENKRSVGLLQACMipgvipfALCLFFSKLVAYTFLywLPFYLSQTTI 360
Cdd:cd06173 200 ------------------------------GLRYLRRSPLLRLLLL-------ALALFALLGGALTVL--LPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 361 GGEyvsvKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSyggVSQTVNILLMMVAGLFvnG 440
Cdd:cd06173 241 GGA----AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLA--G 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684088 441 PYALITTAVSADLGTHKSLQGdsRALATVTAIIDGTGSAGAALGPLLTgflSTLGWQAVFYMLVVGALCAGLLLTRL 517
Cdd:cd06173 312 GLFNVPLNTLLQLRVPDELRG--RVFSVYNALNSGAMPLGALLAGLLA---DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
122-517 |
2.39e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 2.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRlfltWGMIGSGFFVGLFGMGYFWNiHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRK----KVLLPGLLLFGIGGLLCGLS-DSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGWGWSFIAPGFVMSLGgVLVYLFLAAYPEDVGFPDINSNSGKFIKRK 281
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVA-FLAILFLLPEPKEKAKSSSATKLRDLKKAL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 282 RDveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmiPGVIPFALCLFFSKLVAYTFLYWLPFYLSQTtig 361
Cdd:cd17474 196 RG--------------------------------------------RGLLTFLVSAFLYFFLYFAFLTYLPFLLELL--- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 362 gEYVSVKTAGNLSTLFDVGGIVGGILCGYISDK-FKARATTAAAFM-YAAIPAMLVYhsygGVSQTVNILLMMVAGLFVN 439
Cdd:cd17474 229 -YGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLlYALSLLLLGF----VPSLALLLIAIVLFGLGLG 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684088 440 GPYALITTAVSAdlgthkslQGDSRALATVTAIIDGTGSAGAALGPLLTGFL-STLGWQAVFYMLVVGALCAGLLLTRL 517
Cdd:cd17474 304 LNLPLLTTLVTE--------LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLlEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
112-492 |
3.85e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 55.70 E-value: 3.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 112 GTSRLGEIDVAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGmgyfwNIHAFWFFLVMQMAAGLFQATGWP 191
Cdd:cd17328 32 DDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSS-----FAPNFWQLLLFRALVGIGEASYSP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 192 SVVAVVGNWFGKRKRGLIMGIWNAHTSVGN----ICGSLIAAgvLEYGWGWSFIAPGFVMSLGGVLVYLFLAAYPedvgf 267
Cdd:cd17328 107 IAPTIIADLFPKEKRTRALGVFYFAIPLGSglgyVVGGLVAQ--ATGGWRWAFRVTGVLGVLLAILLLLFVREPP----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 268 pdinsnsgkfiKRKRDVEEEEEEVEEDLGTDVEGDGegssgsgsgyeNKRSVGLLqacmipgVIPFALCLFfsklVAYTF 347
Cdd:cd17328 180 -----------RGAAEGGVMAKSTATSFLADLKALA-----------KNPSFILS-------TLGFTAVSF----VTGAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 348 LYWLPFYLSQTTIGGEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKF-----KARATTAAAFMYAAIPAMLVYHSYGGV 422
Cdd:cd17328 227 AFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLrrktpRADPLVCAVGLLAAAPFLFLALVLALS 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684088 423 SQTVNILLMMVAGLFVNGPYALITTAVSADLgthkslqgDSRALATVTAIIDGTGSA-GAALGPLLTGFLS 492
Cdd:cd17328 307 NLLLAWVLLFLGEFLLSLNWAPVFAILLYVV--------IPTRRSTASAIQILLSHLlGDAGSPYLIGLIS 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
144-526 |
2.15e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.37 E-value: 2.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 144 RLFLTWGMIGSG-FFVGLFGMGYFWNIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWFGKRK-RGLIMGIWNAHTSVGN 221
Cdd:COG2211 81 RPWILIGAIPLAlSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 222 ICGSLIAAGVLEY-------GWGWSFIAPGFVMSLGGVLVYLFLaayPEDVGFPDINSNSGKFIKrkrdveeeeeeveed 294
Cdd:COG2211 161 LLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGT---KERPVPEEEKVSLKESLK--------------- 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 295 lgtdvegdgegssgsgSGYENKRsvgllqacmipgvipfalclfFSKLVAYTFLYWLPFYLSQTTIG--GEYV---SVKT 369
Cdd:COG2211 223 ----------------ALLKNRP---------------------FLLLLLAYLLFFLALALVAALLLyyFKYVlglSAAL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 370 AGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIpAMLVYHSYGGVSQTVNILLMMVAGLFVnGPYALITTAV 449
Cdd:COG2211 266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL-GLLLLFFLGPGNLWLLLVLAALAGIGL-GAILVLPWAM 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 450 SADLGTHKSLQGDSRALATVTAIIDGTGSAGAALGPLLTGFL--------------STLGWQAVFYMLV--VGALCAGLL 513
Cdd:COG2211 344 LADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLlalfgyvagaaqspSALTGIRLLFFLLpaVLLLLAALL 423
|
410
....*....|....*...
gi 30684088 514 -----LTRLVIAEIREKL 526
Cdd:COG2211 424 llfypLTRERHAEIRAEL 441
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
121-495 |
3.44e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.56 E-value: 3.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 121 VAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFWNihaFWFFLVMQMAAGLFQATGWPSVVAVVGNW 200
Cdd:cd17321 38 NAYLLAFAALLLLAGRLGDRFGRKRVFLIGLAL--FGLASLLCALAPS---LAFLIAARALQGIGAAAIMPASLALIAAT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 201 FGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEY-GWGWSFIAPGFVMSLGGVLVYLFLAAypedvgfpdinsnsgkfik 279
Cdd:cd17321 113 FPGERRGRALGLWGAVVGIGAALGPLLGGLLLELfGWRWIFLINVPIGLVALLLARTFSGA------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 280 rkrdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmipgvipfALCLFFSKLVAYTFLYWLPFYLsqtt 359
Cdd:cd17321 174 ------------------------------------------------------VLAAFLLGAALGGLLFLLPLYL---- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 360 IGGEYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSYGGVSQTVNILLMMVAGLFVN 439
Cdd:cd17321 196 QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLG 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 30684088 440 GPYALITTAVSADLGTHKSlqgdsralATVTAIIDGTGSAGAALGPLLTGFLSTLG 495
Cdd:cd17321 276 LFATPLTNAALSSVPKEKA--------GAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
333-518 |
6.96e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.26 E-value: 6.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 333 FALCLFFSKLVAYTFLYWLPFYLSQTTiggeYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARAT-TAAAFMYAAIP 411
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDL----GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVlLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 412 AMLVYHSyggvSQTVNILLMMVAGLFVNGPYALITTAVSAdlgthkSLQGDSRALATvtAIIDGTGSAGAALGPLLTGFL 491
Cdd:pfam07690 77 LLLLFAS----SLWLLLVLRVLQGLGAGALFPAALALIAD------WFPPEERGRAL--GLVSAGFGLGAALGPLLGGLL 144
|
170 180
....*....|....*....|....*...
gi 30684088 492 ST-LGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:pfam07690 145 ASlFGWRAAFLILAILSLLAAVLLLLPR 172
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
129-263 |
1.04e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 129 IGMYVAGHLGDSLDLRlflTWGMIGSGFFVGLFGMGYFWNIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWFGKRKRGL 208
Cdd:COG2271 231 VGSLLGGWLSDRLGRR---RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGT 307
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 30684088 209 IMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLAAYPE 263
Cdd:COG2271 308 ASGLVNTFGFLGGALGPLLVGYLLDaTGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
330-518 |
2.45e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.59 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 330 VIPFALCLFFSKLVAYTFLYWLPFYLSQTTiggeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAA 409
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLG-----ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 410 IPAMLVyhsygGVSQTVNILLM--MVAGLFVNGPYALITTAVSADLGTHKslqgdsraLATVTAIIDGTGSAGAALGPLL 487
Cdd:COG2814 87 LGSLLC-----ALAPSLWLLLAarFLQGLGAGALFPAALALIADLVPPER--------RGRALGLLGAGLGLGPALGPLL 153
|
170 180 190
....*....|....*....|....*....|..
gi 30684088 488 TGFL-STLGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:COG2814 154 GGLLaDLFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
121-235 |
6.46e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 6.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 121 VAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFgmgYFWNIHAFWFFLVMQMAAGLFQATGWPSVVAVV--- 197
Cdd:COG2211 271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadv 347
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 30684088 198 ---GNW-FGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYG 235
Cdd:COG2211 348 vdyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
371-518 |
1.09e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.95 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 371 GNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVY--HSYGGVsqtvnILLMMVAGLFVNGPYALITTA 448
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAlaVSYWLL-----LLLGLLLGIGGGGSFAVGIAL 117
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684088 449 VSadlgthKSLQGDSRALAtvTAIIDGTGSAGAALGPLLTGFL-STLGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:COG2223 118 VS------KWFPPDRRGLA--LGLAAGGGNLGAAVAAFLAPLLiAAFGWRNAFLILGILLLVVAVLAWLFL 180
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
370-520 |
1.79e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 370 AGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVyhsygGVSQTVN--ILLMMVAGLFVNGPYALITT 447
Cdd:COG2271 47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF-----GFATSFWqlLLLRFLLGLGEAGFFPAALK 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684088 448 AVSadlgthKSLQGDSRALATvtAIIDGTGSAGAALGPLLTGFL-STLGWQAVFYMLVVGALCAGLLLTRLVIA 520
Cdd:COG2271 122 LIA------EWFPPKERGRAL--GIFNAGGPLGGALAPPLLGWLlAAFGWRAAFLILGLPGLLLALLRFWLLAL 187
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
122-514 |
2.93e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.46 E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLfgMGYFWNIHaFWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:cd17318 64 SFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLL--TPLAARGG-YGALIVLRILQGLAQGVTFPAMHALWAKWA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICgSLIAAGVL--EYGWGWSFIAPGFVmSLGGVLVYLFLaaypedvgfpdinsnsgkfik 279
Cdd:cd17318 141 PPLERSRLTSIAYSGSQFGTVI-AMPLSGFLceSLGWPSIFYIFGGL-GLLWCLLWFFL--------------------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 280 rkrdveeeeeeveedlgtdvegdgegssgsgsgyenkrsvgllqacmipgVIPF---ALCLFFSKLVAYTFLYWLPFYLS 356
Cdd:cd17318 198 --------------------------------------------------VLPVwaiVVAHFGHNWGFYTLLTELPTYMS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 357 QTTiggeYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARAT----------TAAAFMYAAIpaMLVYHSYGGVSQTV 426
Cdd:cd17318 228 DVL----HFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlstttvrklfTSIGFLGPGV--FLIALGYLGSNATL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 427 NILLMMVAGlfvngpyALITTAVSADLGTHKSLQgdSRALATVTAIIDGTGSAGAALGPLLTGFL-----STLGWQAVFY 501
Cdd:cd17318 302 AVVFLTLSV-------GLSGACYSGFLVNHLDLA--PNYAGTLMGITNTAATIAGIISPLIVGAIvkndqTIGQWRIVFF 372
|
410
....*....|...
gi 30684088 502 mLVVGALCAGLLL 514
Cdd:cd17318 373 -ISAAIYILGAIF 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
121-221 |
8.59e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 8.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 121 VAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMgyfwnIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNW 200
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-----AGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
90 100
....*....|....*....|.
gi 30684088 201 FGKRKRGLIMGIWNAHTSVGN 221
Cdd:COG2814 325 APPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
370-518 |
1.17e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 370 AGNLSTLFDVGGIVGGILCGYISDKFKARAT-TAAAFMYAA-IPAMLVYHSYGGVsqtvnILLMMVAGLFvngpYALITT 447
Cdd:cd06174 33 LGLLFALFSLGYALLQPLAGLLADRFGRRPVlLLGLLLFALgALLFAFAPSFWLL-----LLGRFLLGLG----SGLIDP 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684088 448 AVSADLGTHkslqGDSRALATVTAIIDGTGSAGAALGPLLTGFL---STLGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:cd06174 104 AVLALIADL----FPERERGRALGLLQAFGSVGGILGPLLGGILassLGFGWRAVFLIAAALALLAAILLLLVV 173
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
123-258 |
1.34e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 123 FLACYSIGM----YVAGHLGDSLDLRLFLTWGMIGSGFfvGLFGMGYFWNIHAFWFFLVMQ-MAAGLFQATGWPSVVAVV 197
Cdd:cd17329 40 VLALSAVAGivasLIGGRLADRFGRKPVMLAGLLLRAL--GFALLGFAHSPWLFAIALVLTgFGGGLFEPASEAMIADVT 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30684088 198 GNWfgkrKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGWGWSFIAPGFVMSLGGVLVYLFL 258
Cdd:cd17329 118 TPE----NRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLL 174
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
332-525 |
3.97e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 42.96 E-value: 3.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 332 PFALCLFFSKLVAYTFLYWLPFYLSQttIGgeyVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARAttaAAFMYAAIP 411
Cdd:cd17335 1 RLKLFYFFFFAALGSLLPFLSVYLKQ--LG---LSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRK---ALLLLSLLA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 412 AMLVYHSYGGVSQT-VNILLMMVAGLFVNGP-YALITTAVSADLGTHKSLQGDSRalatvtaiidGTGSAGAALGPLLTG 489
Cdd:cd17335 73 AVLFFLSLFFVAQIfWLLLLLVILGAFFSAPvVPLVDSITLQYLGEERERYGKQR----------LWGSIGFGIAALLVG 142
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 30684088 490 FL-----STLGWQAVFYMLVVGALCAGLLLTRLVIAEIREK 525
Cdd:cd17335 143 ILidrssTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPE 183
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
125-514 |
6.46e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 6.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 125 ACYSIGMYVAGHLGDSL-----DLRLFLTWGMIGSGFFVGLFGMGYFWnihaFWFFLvmQMAAGLFQATGWPSVVAVVGN 199
Cdd:cd17477 38 SAYYLGILLGSPLVPRLirrvgHIRAFAAGAAITAVSVLLLALTDSPW----VWFLL--RFVMGIGLAGLFVVSESWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 200 WFGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGWgWSFIAPGFVMSLGGVLVYLFLAAYPEdvgfpdinsnsgkfik 279
Cdd:cd17477 112 LATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA-LPFLIAAVLLLLALVPLLLTRRAAPE---------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 280 rkrdveeeeeeveedlgtdvegdgegssgsgsgYENKRSVGLLQACMIPGViPFALCLFFSKLVAyTFLYWLPFYLSQTT 359
Cdd:cd17477 175 ---------------------------------IEEAESISLRRLLRIAPL-ALLGAFVAGFLEG-AFYSLLPLYGLRLG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 360 IggeyvSVKTAGNLSTLFDVGGIVGGILCGYISDKF-KARATTAAAFMYAAIPAMLVYHSYGGVsqtVNILLMMVAGLFV 438
Cdd:cd17477 220 L-----SVAQAALLLAAFVLGGLLLQWPLGWLADRFdRRRVLLGCALLGALAALLLPLVPGLPL---ALLVLLFLWGGAA 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30684088 439 NGPYALITTAVSADLgthkslqgDSRALATVTAIIDGTGSAGAALGPLLTGFL-STLGWQAVFYMLVVGALCAGLLL 514
Cdd:cd17477 292 GPLYTLALALAGDRL--------PGDELVAANAALLLLYGLGSVIGPLLAGALmDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
365-518 |
9.33e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 9.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 365 VSVKTAGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSyggVSQTVNILLMMVAGLFvNGPYAL 444
Cdd:cd17324 31 VSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA---PSFALLLLARALAGLA-HGGFWA 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30684088 445 ITTAVSADLgTHKSLQGdsRALATVTAIIdgtgSAGAALGPLLTGFLST-LGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:cd17324 107 IAAAYAADL-VPPEKRG--RAIGLVFSGL----TLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLL 174
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
122-262 |
9.80e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.39 E-value: 9.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMGYFWNIhafWFFLVMQMAAGLFQATGWPSVVAVVGNWF 201
Cdd:cd17380 42 SFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSL---PLLILSRILLGLGEGVHFPSMTSLFSRWV 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGfvmSLGGVLVYLFLAAYP 262
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEyYGWPSVFYFFG---LLGLLWALVWLIYLP 177
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
375-518 |
1.36e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 375 TLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVyhsygGVSQTVNILLMMVAGLFV-NGPYALITTAVSADL 453
Cdd:cd17474 41 TAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC-----GLSDSFALLLAGRALQGIgAAGLGPLALTLIGDL 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30684088 454 GTHKSLqgdSRALATVTAIIdgtgSAGAALGPLLTGFLSTLGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:cd17474 116 FEGGER---AKAMGLYEAAL----GLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLL 173
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
123-240 |
1.50e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 41.21 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 123 FLACYSIGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFWNIHAFWFFLVMQmaaGLFQATGWPSVVAVVGNWFG 202
Cdd:TIGR00711 46 YMLANAISIPLTGWLAKRFGTRRLFLISTFA--FTLGSLLCGVAPNLELMIIFRVIQ---GFGGGPLIPLSFSTLLNIYP 120
|
90 100 110
....*....|....*....|....*....|....*....
gi 30684088 203 KRKRGLIMGIWNAHTSVGNICGSLIAAGVLE-YGWGWSF 240
Cdd:TIGR00711 121 PEKRGRAMAIWGLTVLVAPALGPTLGGWIIEnYHWRWIF 159
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
156-258 |
1.57e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.02 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 156 FFVGLFgMGYFWNI-----HAFWFFLVMQMAAGLFQATGWPSVVAVVGNWFGKRKRGLIMGIWNAHTSVGNICGSLIAAG 230
Cdd:cd17323 67 YLVSLF-IFVIFQIgcalaPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGF 145
|
90 100
....*....|....*....|....*....
gi 30684088 231 VLEY-GWGWSFIAPGFVMSLGGVLVYLFL 258
Cdd:cd17323 146 ITQSlGWRWIFWFLAIISGFCLILIFLFL 174
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
342-516 |
1.72e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 40.64 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 342 LVAYTFLYWLPFYLSQTTIGGEyvsvkTAGNLSTLFDVGGIVGGILCGYISDKFK---ARATTAAAFMYAAIPAMLVYHS 418
Cdd:cd17339 210 LLFYTLMAWLPTILIDAGLSAA-----TAGWLLSLFQLVGIPASLLVPILATRLKnqrPIVVLLAVLFIIGVLGLLFAPT 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 419 yggvsqTVNILLMMVAGLFVNG--PYALITTAVSADlgthkslqgDSRALATVTAIIDGTGSAGAALGPLLTGFLS--TL 494
Cdd:cd17339 285 ------ALALLWAVLLGLGGGAafSLALTLISLRSS---------DPAEAAALSGMAQSVGYLLAALGPLLFGVLHdlTG 349
|
170 180
....*....|....*....|....*
gi 30684088 495 GWQAVFYMLVVGAL---CAGLLLTR 516
Cdd:cd17339 350 SWTAPLVLLLALTVlqlVAGLGAGR 374
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
338-544 |
1.80e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 338 FFSKLVAYTFLYWLPFYLSQTTiggeYVSVKTAGNLSTLFDVGGIVGGILCGYISDKFKAR-----ATTAAAFMYAAipa 412
Cdd:cd17329 9 FLNRLGFFMVWPFMAIYLHQQL----GLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKpvmlaGLLLRALGFAL--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 413 MLVYHSyggvsqtvnILLMMVAGLFVNGPYALITTAVSADLGTHKSLQGDSRALATVTAIIdgtgSAGAALGPLLTGFLS 492
Cdd:cd17329 82 LGFAHS---------PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAI----NLGVAIGPLLGGLLL 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 30684088 493 TLGWQAVFYMLVVGALCAGLLLTRLVIAEIREKLGYVDEEVPAS-EPLLTDRR 544
Cdd:cd17329 149 LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGyKIVLRDRA 201
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
365-518 |
1.96e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 365 VSVKTAGNLSTLFDVGGIVGGILCGYISDKFKAR----------ATTAAAFMYAAIPAMLvyhsyggvsqtvnILLMMVA 434
Cdd:cd17325 28 ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKrllllgllllAVSTLLFAFATSYWQL-------------LLARFLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 435 GLFVnGPYALITTAVSADLGTHKSLqgdSRALATVTAIIdgtgSAGAALGPLLTGFLST-LGWQAVFYMLVVGALCAGLL 513
Cdd:cd17325 95 GLAS-AAVWPAAMALIADIAPPEER---GRAMGIFSSAI----GLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVL 166
|
....*
gi 30684088 514 LTRLV 518
Cdd:cd17325 167 ALLLL 171
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
122-241 |
2.01e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.64 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 122 AFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGsgFFVGLFGMGYFWNIHAFWFFLVMQmaaGLFQATGWPSVVAVVGNWF 201
Cdd:cd17503 39 SYLLALAIMIPLSGWLADRFGTRRLFLTALAL--FTLGSLLCGLAPNLASLIIFRILQ---GFGGGVLIPLAQTILLRIY 113
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 30684088 202 GKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEY-GWGWSFI 241
Cdd:cd17503 114 PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNlSWRWIFY 154
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
370-544 |
3.07e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 370 AGNLSTLFDVGGIVGGILCGYISDKFKARATTAAAFMYAAIPAMLVYHSYGgvsqtvniLLMMVAGLFVNG-PYALITTA 448
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--------YPLLLLALFLLGlGLGLLDVA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 449 VSADLGTHKSLQGDSRalatvTAIIDGTGSAGAALGPLLTGFLSTLG----WQAVFYMLVVGALCAGLLLTRLVIAEIRE 524
Cdd:COG0738 117 ANPYVAALGPETAASR-----LNLLHAFFSLGALLGPLLGGLLILLGlslsWHLPYLILAVLLLLLALLFLRSKLPEIEE 191
|
170 180
....*....|....*....|
gi 30684088 525 KLGYVDEEVPASEPLLTDRR 544
Cdd:COG0738 192 EEEEAAGSAASLKSLLKNPR 211
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
121-256 |
3.39e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 121 VAFLACYSIGMYVAGHLGDSLDLRlfltwGMIGSGFFVGLFGMGYFWNIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNW 200
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGRK-----KLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADL 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 30684088 201 FGKRKRGLIMGIWNAHTSVGNICGSLIaAGVL--EYGWGWSFIApGFVMSLGGVLVYL 256
Cdd:cd17370 316 VPAELRGTAYGLFNTVVGIGWLLASLI-AGYLwdLISPSAAFLF-SAVLALIALLLLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
133-518 |
3.81e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 3.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 133 VAGHLGDsldlRLFLTWGMIGSGFFVGLFGMGYFWnIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNWFGKRKRGLIMGI 212
Cdd:cd17489 50 FAGRLLD----RFGRKRLLLIGLLIFALATLLYLL-ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 213 WNAHTSVGNICGSLIAAGVLE-YGWGWSFIAPGFVMSLGGVLVYLFLAAYPEDVGFPDINSNSGKFIKRKRdveeeeeev 291
Cdd:cd17489 125 YGLATTLAMALGPALGLFLYQhLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK--------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 292 eedlgtdvegdgegssgsgsgyenkrsvgllqacmipgVIPFALCLFFSKLVAYTFLYWLPFYLSQTtiggeyvSVKTAG 371
Cdd:cd17489 196 --------------------------------------VLPPALILFLASIAYGAISTFLPLYAAER-------GISNAG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 372 NLSTLFDVGGIVGGILCGYISDKFkarattaaAFMYAAIPAMLVYH-SYGGVSQTVNILLMMVAGLFVNGPYALITTAVS 450
Cdd:cd17489 231 LFFTVYAIALLLSRPFSGKLSDRK--------GPKTVIIPGLLLLAlGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQ 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684088 451 ADLGTHKSLQGDSRALATVTAIIDgtgsAGAALGPLLTGFLST-LGWQAVFYMLVVGALCAGLLLTRLV 518
Cdd:cd17489 303 ALAVDLVPPHRRGAANGTFFIFFD----LGIGLGGLLLGLVAElFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| NI9M |
cd22903 |
NADH:Ubiquinone Oxidoreductase, N9IM subunit; NI9M is a subunit of the NADH:ubiquinone ... |
498-539 |
4.22e-03 |
|
NADH:Ubiquinone Oxidoreductase, N9IM subunit; NI9M is a subunit of the NADH:ubiquinone oxidoreductase (Respiratory complex I), which is a redox-driven proton pump that plays an important role in creating the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. NI9M is a single-pass membrane protein and a fungal subunit homologous to NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) that is considered an accessory subunit.
Pssm-ID: 438578 Cd Length: 66 Bit Score: 35.95 E-value: 4.22e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 30684088 498 AVFYMLVVGALCAGLLLTrlvIAEIREKLGYVD-EEVPASEPL 539
Cdd:cd22903 14 AIFWSIVIGAAGPVLLLT---VPPIRRRLGYKDaEPIPTTYPL 53
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
121-260 |
5.43e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 5.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 121 VAFLACYSIGMYVAGHLGDSLDLRLFLTWGMIGSGFFVGLFGMgyfWNIHAFWFFLVMQMAAGLFQATGWPSVVAVVGNW 200
Cdd:cd17316 220 LLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFY---LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684088 201 FGKRKRGLIMGIWNAHTSVGNICGSLIAAGVLEYGWGWSFIApgfVMSLGGVLVYLFLAA 260
Cdd:cd17316 297 FPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA---LILALLAIVALIVAL 353
|
|
| |
