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Conserved domains on  [gi|145340466|ref|NP_193845|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
121-451 1.86e-40

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.86e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 121 VRRANALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKsdeykwpsdevlkshglkfQES 200
Cdd:COG2319   96 ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------------LLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 201 WYTRHNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCF-REGTAeLFSGSYDGTLSIWNAEH 279
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGKL-LASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 280 RTYIESCFGHQSELLSID-ALGRERVLSVGRDRTMQLYKVPESTRL-IYRASESNFECCCFVNSDEFL-SGSDNGSIALW 356
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLaSGSDDGTVRLW 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 357 SILKKKPVfivnnahHVIADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLWGVESGssaiQPLYELP-LPGF 435
Cdd:COG2319  316 DLATGKLL-------RTLTGHT----------GAVRSVAFSPDGKTLASGSDDGTVRLWDLATG----ELLRTLTgHTGA 374

                        330
                 ....*....|....*.
gi 145340466 436 VNSLAFAKSGRFLIAG 451
Cdd:COG2319  375 VTSVAFSPDGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
121-451 1.86e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.86e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 121 VRRANALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKsdeykwpsdevlkshglkfQES 200
Cdd:COG2319   96 ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------------LLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 201 WYTRHNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCF-REGTAeLFSGSYDGTLSIWNAEH 279
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGKL-LASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 280 RTYIESCFGHQSELLSID-ALGRERVLSVGRDRTMQLYKVPESTRL-IYRASESNFECCCFVNSDEFL-SGSDNGSIALW 356
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLaSGSDDGTVRLW 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 357 SILKKKPVfivnnahHVIADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLWGVESGssaiQPLYELP-LPGF 435
Cdd:COG2319  316 DLATGKLL-------RTLTGHT----------GAVRSVAFSPDGKTLASGSDDGTVRLWDLATG----ELLRTLTgHTGA 374

                        330
                 ....*....|....*.
gi 145340466 436 VNSLAFAKSGRFLIAG 451
Cdd:COG2319  375 VTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-415 1.19e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 1.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 125 NALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKSDEYkwpsdevlkshglkfqeswYTR 204
Cdd:cd00200   31 GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-------------------LTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 205 HNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRTYIE 284
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 285 SCFGHQSELLSIDALG-RERVLSVGRDRTMQLYKVPESTRL-IYRASESNFECCCF-VNSDEFLSGSDNGSIALWSILKK 361
Cdd:cd00200  172 TLTGHTGEVNSVAFSPdGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFsPDGYLLASGSEDGTIRVWDLRTG 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145340466 362 KPVfivnnahHVIADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLW 415
Cdd:cd00200  252 ECV-------QTLSGHT----------NSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-276 8.18e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 8.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 145340466   237 TREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWN 276
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
238-276 3.29e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.29e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 145340466  238 REHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWN 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
121-451 1.86e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 1.86e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 121 VRRANALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKsdeykwpsdevlkshglkfQES 200
Cdd:COG2319   96 ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------------LLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 201 WYTRHNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCF-REGTAeLFSGSYDGTLSIWNAEH 279
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFsPDGKL-LASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 280 RTYIESCFGHQSELLSID-ALGRERVLSVGRDRTMQLYKVPESTRL-IYRASESNFECCCFVNSDEFL-SGSDNGSIALW 356
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLaSGSDDGTVRLW 315

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 357 SILKKKPVfivnnahHVIADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLWGVESGssaiQPLYELP-LPGF 435
Cdd:COG2319  316 DLATGKLL-------RTLTGHT----------GAVRSVAFSPDGKTLASGSDDGTVRLWDLATG----ELLRTLTgHTGA 374

                        330
                 ....*....|....*.
gi 145340466 436 VNSLAFAKSGRFLIAG 451
Cdd:COG2319  375 VTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
125-419 6.55e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 6.55e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 125 NALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKsdeykwpsdeVLKShglkfqeswYTR 204
Cdd:COG2319  142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK----------LLRT---------LTG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 205 HNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRTYIE 284
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 285 SCFGHQSELLSI----DalGReRVLSVGRDRTMQLYKVPESTRL-IYRASESNFECCCFVNSDEFL-SGSDNGSIALWSI 358
Cdd:COG2319  283 TLTGHSGGVNSVafspD--GK-LLASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSPDGKTLaSGSDDGTVRLWDL 359

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145340466 359 LKKKPVfivnnahHVIADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLWGVES 419
Cdd:COG2319  360 ATGELL-------RTLTGHT----------GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
122-451 1.74e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 1.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 122 RRANALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKsdeykwpsdevlkshglkfQESW 201
Cdd:COG2319   55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL-------------------LLRT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 202 YTRHNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRT 281
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 282 YIESCFGHQSELLSID-ALGRERVLSVGRDRTMQLYKVPESTRL-IYRASESNFECCCFVNSDEFL-SGSDNGSIALWSI 358
Cdd:COG2319  196 LLRTLTGHTGAVRSVAfSPDGKLLASGSADGTVRLWDLATGKLLrTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDL 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 359 LKKKPVfivnnahHVIADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLWGVESGssaiQPLYELP-LPGFVN 437
Cdd:COG2319  276 ATGELL-------RTLTGHS----------GGVNSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLTgHTGAVR 334

                        330
                 ....*....|....
gi 145340466 438 SLAFAKSGRFLIAG 451
Cdd:COG2319  335 SVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-415 1.19e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 1.19e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 125 NALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKSDEYkwpsdevlkshglkfqeswYTR 204
Cdd:cd00200   31 GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-------------------LTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 205 HNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRTYIE 284
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 285 SCFGHQSELLSIDALG-RERVLSVGRDRTMQLYKVPESTRL-IYRASESNFECCCF-VNSDEFLSGSDNGSIALWSILKK 361
Cdd:cd00200  172 TLTGHTGEVNSVAFSPdGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSVAFsPDGYLLASGSEDGTIRVWDLRTG 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145340466 362 KPVfivnnahHVIADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLW 415
Cdd:cd00200  252 ECV-------QTLSGHT----------NSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-451 2.10e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.14  E-value: 2.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 139 RVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGksdeykwpsdEVLKShglkfqeswYTRHNKQSLALAVSSDG 218
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG----------ELLRT---------LKGHTGPVRDVAASADG 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 219 RYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRTYIESCFGHQSELLSIDA 298
Cdd:cd00200   64 TYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 299 LGRERVLSVG-RDRTMQLYKVpESTRLIYRAS--ESNFECCCFV-NSDEFLSGSDNGSIALWSILKKKPVfivnnahHVI 374
Cdd:cd00200  144 SPDGTFVASSsQDGTIKLWDL-RTGKCVATLTghTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCL-------GTL 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145340466 375 ADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLWGVESGssaiQPLYELPLP-GFVNSLAFAKSGRFLIAG 451
Cdd:cd00200  216 RGHE----------NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG----ECVQTLSGHtNSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-357 2.55e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 2.55e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 125 NALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKSdEYkwpsdeVLKSHglkfqESWYTr 204
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-LT------TLRGH-----TDWVN- 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 205 hnkqslALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRTYIE 284
Cdd:cd00200  140 ------SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145340466 285 SCFGHQSELLSIDALGRERVLSVG-RDRTMQLYKV-PESTRLIYRASESNFECCCFVNSDEFL-SGSDNGSIALWS 357
Cdd:cd00200  214 TLRGHENGVNSVAFSPDGYLLASGsEDGTIRVWDLrTGECVQTLSGHTNSVTSLAWSPDGKRLaSGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 240-451 6.12e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 6.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 240 HVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRTYIESCFGHQSELLSIDALG-RERVLSVGRDRTMQLYKV 318
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAdGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 319 --PESTRlIYRASESNFECCCFVNSDEFL-SGSDNGSIALWSILKKKPVFivnnahhVIADHDsvnhnctpacSWVSSVA 395
Cdd:cd00200   81 etGECVR-TLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLT-------TLRGHT----------DWVNSVA 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145340466 396 VCRGSELAASGAGNGCVRLWGVESGSsaiqPLYELPLP-GFVNSLAFAKSGRFLIAG 451
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLWDLRTGK----CVATLTGHtGEVNSVAFSPDGEKLLSS 195
WD40 COG2319
WD40 repeat [General function prediction only];
203-451 3.41e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 3.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 203 TRHNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRTY 282
Cdd:COG2319   33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 283 IESCFGHQSELLSI--DALGReRVLSVGRDRTMQLYKVPESTRL-IYRASESNFECCCFVNSDEFL-SGSDNGSIALWSI 358
Cdd:COG2319  113 LRTLTGHTGAVRSVafSPDGK-TLASGSADGTVRLWDLATGKLLrTLTGHSGAVTSVAFSPDGKLLaSGSDDGTVRLWDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 359 LKKKPVfivnnahHVIADHDsvnhnctpacSWVSSVAVCRGSELAASGAGNGCVRLWGVESGssaiQPLYELPLP-GFVN 437
Cdd:COG2319  192 ATGKLL-------RTLTGHT----------GAVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLTGHsGSVR 250

                        250
                 ....*....|....
gi 145340466 438 SLAFAKSGRFLIAG 451
Cdd:COG2319  251 SVAFSPDGRLLASG 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-297 2.09e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 2.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 122 RRANALRVQDLQSSDKFRVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWDVSSGKsdeykwpsdeVLKSHglkfqesw 201
Cdd:cd00200  112 SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK----------CVATL-------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340466 202 yTRHNKQSLALAVSSDGRYLATGGVDCHVHLWDIRTREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWNAEHRT 281
Cdd:cd00200  174 -TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                        170
                 ....*....|....*.
gi 145340466 282 YIESCFGHQSELLSID 297
Cdd:cd00200  253 CVQTLSGHTNSVTSLA 268
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-276 8.18e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 8.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 145340466   237 TREHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWN 276
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-234 2.16e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 145340466   202 YTRHNKQSLALAVSSDGRYLATGGVDCHVHLWD 234
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
238-276 3.29e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.29e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 145340466  238 REHVQAFTGHCGIVSSLCFREGTAELFSGSYDGTLSIWN 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
202-234 9.80e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.80e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 145340466  202 YTRHNKQSLALAVSSDGRYLATGGVDCHVHLWD 234
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-173 1.14e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 145340466   139 RVIVKHQHSVTGVALSDDDSRGFSVSKDGTILHWD 173
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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