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Conserved domains on  [gi|22328952|ref|NP_194390|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

NOL1/NOP2/SUN domain family protein( domain architecture ID 1003105)

NOL1/NOP2/SUN domain (NSUN) family protein such as mammalian nucleolar protein NOP2 which is required for nucleolar maturation and ribosome biogenesis

Gene Ontology:  GO:0003723|GO:0000027|GO:0008173|GO:0001510

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
nop2p super family cl33194
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 270-546 6.82e-109

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


The actual alignment was detected with superfamily member TIGR00446:

Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 329.81  E-value: 6.82e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   270 IRTNTLKTRRRDLADILLNRGVNLDPLSKWSKVGliVYDSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDM 349
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   350 AAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQssVDRVLLDAPCSGTGVI 429
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLK--FDAILLDAPCSGEGVI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   430 SKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPENEAVIDYALKNR-DVKLVPcglDFGR 508
Cdd:TIGR00446 157 RKDPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEI---IKGD 229

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 22328952   509 PGFSSFREhrfHPSLEKTRRFYPHVHNMDGFFVAKLKK 546
Cdd:TIGR00446 230 EFFGINIG---KGEVKGALRVFPQNYDCEGFFVAKLRK 264
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 270-546 6.82e-109

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 329.81  E-value: 6.82e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   270 IRTNTLKTRRRDLADILLNRGVNLDPLSKWSKVGliVYDSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDM 349
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   350 AAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQssVDRVLLDAPCSGTGVI 429
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLK--FDAILLDAPCSGEGVI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   430 SKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPENEAVIDYALKNR-DVKLVPcglDFGR 508
Cdd:TIGR00446 157 RKDPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEI---IKGD 229

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 22328952   509 PGFSSFREhrfHPSLEKTRRFYPHVHNMDGFFVAKLKK 546
Cdd:TIGR00446 230 EFFGINIG---KGEVKGALRVFPQNYDCEGFFVAKLRK 264
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 230-546 2.77e-91

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 290.37  E-value: 2.77e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952 230 ADLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPlSKWSKVGLIVyDS 309
Cdd:COG0144 139 ERLAVRYSHPEWLVERLRAAYGPEEAEALLAALNEPPPLDLRVNTLKASREELLARLAEEGIEAEP-TPLSPDGLRL-EG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952 310 QVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHR 389
Cdd:COG0144 217 PGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLAR 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952 390 MGVTNTIVCNYDGRELTKVLGQsSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTG 469
Cdd:COG0144 297 LGLSNVEVVVADARELLEWLPG-KFDRVLLDAPCSGTGTLRRHPDIKWRRTPEDIAELAALQRELLDAAARLL----KPG 371

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22328952 470 GYIVYSTCSVMIPENEAVIDYALKNR-DVKLVPCGLDFGRPGFSSfrehrfhpslEKTRRFYPHVHNMDGFFVAKLKK 546
Cdd:COG0144 372 GRLVYSTCSLLPEENEEVVEAFLARHpDFELVPLAELLPGLALTD----------GGYLRLLPHRHGTDGFFIARLRK 439
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 335-545 1.11e-83

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 261.97  E-value: 1.11e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   335 VMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQSSV 414
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQPDQWLGGVLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   415 DRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPENEAVIDYALKN 494
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLL----KPGGVLVYSTCSVLPEENEAVIEYFLQK 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22328952   495 R-DVKLVPcgldfgrpgFSSFREHRFHPSLEKTRRFYPHVHNMDGFFVAKLK 545
Cdd:pfam01189 157 HpDVELVP---------TPLFEPVGLAIGEQPTLRLLPHTHNGDGFFIAKLR 199
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
200-546 4.42e-63

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 216.20  E-value: 4.42e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  200 REIVRilSNFKDLKPKGDKHERndyvgqlkadLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRR 279
Cdd:PRK14902 123 RNILR--EGLPDIDEIKDPVKR----------LSIKYSHPVWLVKRWIDQYGEEKAEKILESLNEPPKASIRVNTLKISV 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  280 RDLADILLNRGVNLDPlSKWSKVGLIVydSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTY 359
Cdd:PRK14902 191 EELIEKLEEEGYEVEE-SLLSPEALVI--EKGNIAGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTH 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  360 VAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQSSvDRVLLDAPCSGTGVISKDESVKTSK 439
Cdd:PRK14902 268 IAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNIETKALDARKVHEKFAEKF-DKILVDAPCSGLGVIRRKPDIKYNK 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  440 SADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPENEAVIDYALK-NRDVKLVPcgLDFGRPgfssfrEHR 518
Cdd:PRK14902 347 TKEDIESLQEIQLEILESVAQYL----KKGGILVYSTCTIEKEENEEVIEAFLEeHPEFELVP--LQHEKP------DEL 414

                        330       340
                 ....*....|....*....|....*...
gi 22328952  519 FHPSLEKTRRFYPHVHNMDGFFVAKLKK 546
Cdd:PRK14902 415 VYEVKDGYLQILPNDYGTDGFFIAKLRK 442
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 270-546 6.82e-109

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 329.81  E-value: 6.82e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   270 IRTNTLKTRRRDLADILLNRGVNLDPLSKWSKVGliVYDSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDM 349
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   350 AAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQssVDRVLLDAPCSGTGVI 429
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLK--FDAILLDAPCSGEGVI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   430 SKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPENEAVIDYALKNR-DVKLVPcglDFGR 508
Cdd:TIGR00446 157 RKDPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEI---IKGD 229

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 22328952   509 PGFSSFREhrfHPSLEKTRRFYPHVHNMDGFFVAKLKK 546
Cdd:TIGR00446 230 EFFGINIG---KGEVKGALRVFPQNYDCEGFFVAKLRK 264
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 230-546 2.77e-91

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 290.37  E-value: 2.77e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952 230 ADLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPlSKWSKVGLIVyDS 309
Cdd:COG0144 139 ERLAVRYSHPEWLVERLRAAYGPEEAEALLAALNEPPPLDLRVNTLKASREELLARLAEEGIEAEP-TPLSPDGLRL-EG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952 310 QVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHR 389
Cdd:COG0144 217 PGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLAR 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952 390 MGVTNTIVCNYDGRELTKVLGQsSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTG 469
Cdd:COG0144 297 LGLSNVEVVVADARELLEWLPG-KFDRVLLDAPCSGTGTLRRHPDIKWRRTPEDIAELAALQRELLDAAARLL----KPG 371

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22328952 470 GYIVYSTCSVMIPENEAVIDYALKNR-DVKLVPCGLDFGRPGFSSfrehrfhpslEKTRRFYPHVHNMDGFFVAKLKK 546
Cdd:COG0144 372 GRLVYSTCSLLPEENEEVVEAFLARHpDFELVPLAELLPGLALTD----------GGYLRLLPHRHGTDGFFIARLRK 439
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 335-545 1.11e-83

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 261.97  E-value: 1.11e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   335 VMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQSSV 414
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQPDQWLGGVLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   415 DRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPENEAVIDYALKN 494
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLL----KPGGVLVYSTCSVLPEENEAVIEYFLQK 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22328952   495 R-DVKLVPcgldfgrpgFSSFREHRFHPSLEKTRRFYPHVHNMDGFFVAKLK 545
Cdd:pfam01189 157 HpDVELVP---------TPLFEPVGLAIGEQPTLRLLPHTHNGDGFFIAKLR 199
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
200-546 4.42e-63

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 216.20  E-value: 4.42e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  200 REIVRilSNFKDLKPKGDKHERndyvgqlkadLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRR 279
Cdd:PRK14902 123 RNILR--EGLPDIDEIKDPVKR----------LSIKYSHPVWLVKRWIDQYGEEKAEKILESLNEPPKASIRVNTLKISV 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  280 RDLADILLNRGVNLDPlSKWSKVGLIVydSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTY 359
Cdd:PRK14902 191 EELIEKLEEEGYEVEE-SLLSPEALVI--EKGNIAGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTH 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  360 VAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQSSvDRVLLDAPCSGTGVISKDESVKTSK 439
Cdd:PRK14902 268 IAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNIETKALDARKVHEKFAEKF-DKILVDAPCSGLGVIRRKPDIKYNK 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  440 SADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPENEAVIDYALK-NRDVKLVPcgLDFGRPgfssfrEHR 518
Cdd:PRK14902 347 TKEDIESLQEIQLEILESVAQYL----KKGGILVYSTCTIEKEENEEVIEAFLEeHPEFELVP--LQHEKP------DEL 414

                        330       340
                 ....*....|....*....|....*...
gi 22328952  519 FHPSLEKTRRFYPHVHNMDGFFVAKLKK 546
Cdd:PRK14902 415 VYEVKDGYLQILPNDYGTDGFFIAKLRK 442
yebU PRK11933
rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed
 269-548 2.18e-59

rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed


Pssm-ID: 183387 [Multi-domain]  Cd Length: 470  Bit Score: 206.68  E-value: 2.18e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  269 SIRTNTLKTRRRDLADILLNRGVNLDPLSkWSKVGL-IVYD--SQVPIGATPEYLAGFYMLQSASSFLPVMAL--APREK 343
Cdd:PRK11933  36 SIRVNTLKISVADFLQLMAPYGWTLTPIP-WCEEGFwIERDdeDALPLGNTAEHLSGLFYIQEASSMLPVAALfaDDNAP 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  344 ERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGReltkVLGQ---SSVDRVLLD 420
Cdd:PRK11933 115 QRVLDMAAAPGSKTTQIAALMNNQGAIVANEYSASRVKVLHANISRCGVSNVALTHFDGR----VFGAalpETFDAILLD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  421 APCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPENEAVIDYaLKNR---DV 497
Cdd:PRK11933 191 APCSGEGTVRKDPDALKNWSPESNLEIAATQRELIESAFHAL----KPGGTLVYSTCTLNREENQAVCLW-LKETypdAV 265

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 22328952  498 KLVPCGLDFgrpgfssfrehrfhPSLEKTR------RFYPHVHNMDGFFVAKLKKMS 548
Cdd:PRK11933 266 EFEPLGDLF--------------PGAEKALteegflHVFPQIYDSEGFFVARLRKTA 308
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
 232-546 4.17e-51

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 183.21  E-value: 4.17e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  232 LSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPLSKWSKvGLIVYDSQV 311
Cdd:PRK14901 143 LAILHSFPDWLVKLWLEWLGLEEAEQLCKWFNQPPSLDLRINPLRTSLEEVQAALAEAGITATPIPGLPQ-GLRLTGNPG 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  312 PIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMG 391
Cdd:PRK14901 222 SIRQLPGYEEGWWTVQDRSAQLVAPLLDPQPGEVILDACAAPGGKTTHIAELMGDQGEIWAVDRSASRLKKLQENAQRLG 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  392 VTNTIVCNYDGRELTKVLGQ--SSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTG 469
Cdd:PRK14901 302 LKSIKILAADSRNLLELKPQwrGYFDRILLDAPCSGLGTLHRHPDARWRQTPEKIQELAPLQAELLESLAPLL----KPG 377

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22328952  470 GYIVYSTCSVMIPENEAVIDYAL-KNRDVKLVPcgldfgrpgfssfrehrfhpslEKTRRfYPHVHNMDGFFVAKLKK 546
Cdd:PRK14901 378 GTLVYATCTLHPAENEAQIEQFLaRHPDWKLEP----------------------PKQKI-WPHRQDGDGFFMAVLRK 432
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
 236-546 1.89e-44

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 164.66  E-value: 1.89e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   236 YGYNEFLIGTLIEMFPVVElMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPLSKWSKVglIVYDSQVPIGA 315
Cdd:TIGR00563 135 YLHPEWLVKRLQKAYPGQW-QSICEANNQRPPMWLRINRTKHSRDEWLALLAEAGMKGFPHDLAPDA--VRLETPAAVHA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   316 TPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNtGIIYANEMKVPRLKSLSANLHRMGVTNT 395
Cdd:TIGR00563 212 LPGFEEGWVTVQDASAQWVATWLAPQNEETILDACAAPGGKTTHILELAPQ-AQVVALDIHEHRLKRVYENLKRLGLTIK 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952   396 I-VCNYDGRELTKVLGQSSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQlILGAI-DLVdansKTGGYIV 473
Cdd:TIGR00563 291 AeTKDGDGRGPSQWAENEQFDRILLDAPCSATGVIRRHPDIKWLRKPRDIAELAELQSE-ILDAIwPLL----KTGGTLV 365

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22328952   474 YSTCSVMIPENEAVIDYALKNRdvklvpCGLDFGRPGFSSF-REHRFhpslektrRFYPHVHNMDGFFVAKLKK 546
Cdd:TIGR00563 366 YATCSVLPEENSEQIKAFLQEH------PDFPFEKTGTPEQvRDGGL--------QILPHAEEGDGFFYAKLIK 425
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
220-546 9.35e-34

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 134.16  E-value: 9.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  220 ERNDYVGQLKADLSSYYGYNEFLIGTLIEMFPVvELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPlSKW 299
Cdd:PRK10901 125 EQEELLAELQADPVARYNHPSWLIKRLKKAYPE-QWQAILAANNQRPPMWLRVNRRHHSRDAYLALLAEAGIEAFP-HAV 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  300 SKVGlIVYDSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIyANEMKVPR 379
Cdd:PRK10901 203 GPDA-IRLETPVPVHQLPGFAEGWVSVQDAAAQLAATLLAPQNGERVLDACAAPGGKTAHILELAPQAQVV-ALDIDAQR 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  380 LKSLSANLHRMGVTNTIVCNyDGRELTKVLGQSSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLIlgai 459
Cdd:PRK10901 281 LERVRENLQRLGLKATVIVG-DARDPAQWWDGQPFDRILLDAPCSATGVIRRHPDIKWLRRPEDIAALAALQSEIL---- 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  460 dlvDA---NSKTGGYIVYSTCSVMIPENEAVIDYAL-KNRDVKLVPCGLDFGRPgfssfrehrfhpslektRRFYPHVHN 535
Cdd:PRK10901 356 ---DAlwpLLKPGGTLLYATCSILPEENEQQIKAFLaRHPDAELLDTGTPQQPG-----------------RQLLPGEED 415

                        330
                 ....*....|.
gi 22328952  536 MDGFFVAKLKK 546
Cdd:PRK10901 416 GDGFFYALLIK 426
PRK14903 PRK14903
16S rRNA methyltransferase B; Provisional
 231-500 1.33e-32

16S rRNA methyltransferase B; Provisional


Pssm-ID: 184896 [Multi-domain]  Cd Length: 431  Bit Score: 130.76  E-value: 1.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  231 DLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPlSKWSKVGLIVYDSQ 310
Cdd:PRK14903 127 ELHLKYSHPKWLVNYWRSFLPEEAVLRIMEWNQEPLPTMLRVNSLAITREEVIKILAEEGTEAVP-GKHSPFSLIVRKLG 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  311 VPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRM 390
Cdd:PRK14903 206 VNMNDSRVIKDGLATVQGESSQIVPLLMELEPGLRVLDTCAAPGGKTTAIAELMKDQGKILAVDISREKIQLVEKHAKRL 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  391 GVTNTIVCNYDGRELTKVLgQSSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGG 470
Cdd:PRK14903 286 KLSSIEIKIADAERLTEYV-QDTFDRILVDAPCTSLGTARNHPEVLRRVNKEDFKKLSEIQLRIVSQAWKLL----EKGG 360

                        250       260       270
                 ....*....|....*....|....*....|.
gi 22328952  471 YIVYSTCSVMIPEN-EAVIDYALKNRDVKLV 500
Cdd:PRK14903 361 ILLYSTCTVTKEENtEVVKRFVYEQKDAEVI 391
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
 327-493 7.39e-26

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 110.92  E-value: 7.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  327 QSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVtnTIVCNYDGRELT 406
Cdd:PRK14904 235 QNPTQALACLLLNPQPGSTVLDLCAAPGGKSTFMAELMQNRGQITAVDRYPQKLEKIRSHASALGI--TIIETIEGDARS 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22328952  407 KVLGQsSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVDAnsktGGYIVYSTCSVMIPENEA 486
Cdd:PRK14904 313 FSPEE-QPDAILLDAPCTGTGVLGRRAELRWKLTPEKLAELVGLQAELLDHAASLLKP----GGVLVYATCSIEPEENEL 387


                 ....*..
gi 22328952  487 VIDYALK 493
Cdd:PRK14904 388 QIEAFLQ 394
Methyltr_RsmF_N pfam17125
N-terminal domain of 16S rRNA methyltransferase RsmF; This is the N-terminal domain of the ...
 257-331 1.45e-10

N-terminal domain of 16S rRNA methyltransferase RsmF; This is the N-terminal domain of the RsmF methyl transferase. RsmF is a multi-site-specific methyltransferase that is responsible for the synthesis of three modifications on cytidines in 16S ribosomal RNA. The N-terminus is critical for stabilising the catalytic core of the enzyme.


Pssm-ID: 465356 [Multi-domain]  Cd Length: 88  Bit Score: 57.87  E-value: 1.45e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22328952   257 ELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRgvnLDPLSkWSKVGLIVYDSQVPiGATPEYLAGFYMLQSASS 331
Cdd:pfam17125  19 AFLAAYDEPRPVGLRVNTLKISVEEFLKLSPFE---LEPVP-WCEEGFYLEERPRP-GKHPYHHAGLYYIQEPSA 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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