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Conserved domains on  [gi|15233624|ref|NP_194688|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1904022)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Penicillium polonicum methyltransferase verB

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_11 super family cl48003
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 179-251 4.10e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


The actual alignment was detected with superfamily member pfam08241:

Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 55.75  E-value: 4.10e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15233624   179 RIVGMGMNEEELKR-----NPVLTEYIVQDLnlnSNLPFEDNSFQVITNVVSVDYLTKPLEVFKEMNRILKPGGLALM 251
Cdd:pfam08241  20 RVTGVDISPEMLELarekaPREGLTFVVGDA---EDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 179-251 4.10e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 55.75  E-value: 4.10e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15233624   179 RIVGMGMNEEELKR-----NPVLTEYIVQDLnlnSNLPFEDNSFQVITNVVSVDYLTKPLEVFKEMNRILKPGGLALM 251
Cdd:pfam08241  20 RVTGVDISPEMLELarekaPREGLTFVVGDA---EDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 153-252 9.75e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 56.16  E-value: 9.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233624 153 SDTPGVSILDMCSSwvshypPGY-------RQERIVGMGMNEEELKR-------NPVLTEYIVQDLnlnSNLPFEDNSFQ 218
Cdd:COG2226  19 GLRPGARVLDLGCG------TGRlalalaeRGARVTGVDISPEMLELareraaeAGLNVEFVVGDA---EDLPFPDGSFD 89

                        90       100       110
                ....*....|....*....|....*....|....
gi 15233624 219 VITNVVSVDYLTKPLEVFKEMNRILKPGGLALMS 252
Cdd:COG2226  90 LVISSFVLHHLPDPERALAEIARVLKPGGRLVVV 123
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 209-254 9.94e-08

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 52.08  E-value: 9.94e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 15233624  209 NLPFEDNSFQVIT------NVvsvdylTKPLEVFKEMNRILKPGG-LALMSFS 254
Cdd:PRK00216 114 ALPFPDNSFDAVTiafglrNV------PDIDKALREMYRVLKPGGrLVILEFS 160
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 156-254 2.05e-07

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 50.72  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233624   156 PGVSILDMCS-------SWVSHYPPgyrQERIVGMGMNEEELK------RNPVLTEYIVQDLnlnSNLPFEDNSFQVITN 222
Cdd:TIGR01934  39 KGQKVLDVACgtgdlaiELAKSAPD---RGKVTGVDFSSEMLEvakkksELPLNIEFIQADA---EALPFEDNSFDAVTI 112

                          90       100       110
                  ....*....|....*....|....*....|...
gi 15233624   223 VVSVDYLTKPLEVFKEMNRILKPGG-LALMSFS 254
Cdd:TIGR01934 113 AFGLRNVTDIQKALREMYRVLKPGGrLVILEFS 145
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 179-251 4.10e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 55.75  E-value: 4.10e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15233624   179 RIVGMGMNEEELKR-----NPVLTEYIVQDLnlnSNLPFEDNSFQVITNVVSVDYLTKPLEVFKEMNRILKPGGLALM 251
Cdd:pfam08241  20 RVTGVDISPEMLELarekaPREGLTFVVGDA---EDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 153-252 9.75e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 56.16  E-value: 9.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233624 153 SDTPGVSILDMCSSwvshypPGY-------RQERIVGMGMNEEELKR-------NPVLTEYIVQDLnlnSNLPFEDNSFQ 218
Cdd:COG2226  19 GLRPGARVLDLGCG------TGRlalalaeRGARVTGVDISPEMLELareraaeAGLNVEFVVGDA---EDLPFPDGSFD 89

                        90       100       110
                ....*....|....*....|....*....|....
gi 15233624 219 VITNVVSVDYLTKPLEVFKEMNRILKPGGLALMS 252
Cdd:COG2226  90 LVISSFVLHHLPDPERALAEIARVLKPGGRLVVV 123
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 188-247 5.19e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.87  E-value: 5.19e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15233624   188 EELKRNPVLTEYIVQDLnlnSNLPFEDNSFQVITNVVSVDYLTKP--LEVFKEMNRILKPGG 247
Cdd:pfam13649  38 ERAAEAGLNVEFVQGDA---EDLPFPDGSFDLVVSSGVLHHLPDPdlEAALREIARVLKPGG 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 209-254 9.94e-08

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 52.08  E-value: 9.94e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 15233624  209 NLPFEDNSFQVIT------NVvsvdylTKPLEVFKEMNRILKPGG-LALMSFS 254
Cdd:PRK00216 114 ALPFPDNSFDAVTiafglrNV------PDIDKALREMYRVLKPGGrLVILEFS 160
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 156-254 2.05e-07

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 50.72  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233624   156 PGVSILDMCS-------SWVSHYPPgyrQERIVGMGMNEEELK------RNPVLTEYIVQDLnlnSNLPFEDNSFQVITN 222
Cdd:TIGR01934  39 KGQKVLDVACgtgdlaiELAKSAPD---RGKVTGVDFSSEMLEvakkksELPLNIEFIQADA---EALPFEDNSFDAVTI 112

                          90       100       110
                  ....*....|....*....|....*....|...
gi 15233624   223 VVSVDYLTKPLEVFKEMNRILKPGG-LALMSFS 254
Cdd:TIGR01934 113 AFGLRNVTDIQKALREMYRVLKPGGrLVILEFS 145
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 198-255 2.27e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 46.16  E-value: 2.27e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15233624 198 EYIVQDLnlnSNLPFEDNSFQVITNVVSVDYLTKPLEVFKEMNRILKPGGLALMSFSN 255
Cdd:COG2227  72 DFVQGDL---EDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
204-252 3.91e-05

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 43.32  E-value: 3.91e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 15233624 204 LNLNSNLPFEDNSFQVItnvVSVD-----YLTKPLEVFKEMNRILKPGGLALMS 252
Cdd:COG4627  34 GDLTDPLPFPDNSVDAI---YSSHvlehlDYEEAPLALKECYRVLKPGGILRIV 84
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
154-254 2.94e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 41.66  E-value: 2.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15233624   154 DTPGVSILDMC---SSWVSHYPPGYRQE-RIVGMGMNEEELK--RNPVLTEYIVQDLNLNSN---LPFEDNSFQVITNVV 224
Cdd:pfam01209  40 VKRGNKFLDVAggtGDWTFGLSDSAGSSgKVVGLDINENMLKegEKKAKEEGKYNIEFLQGNaeeLPFEDDSFDIVTISF 119

                          90       100       110
                  ....*....|....*....|....*....|.
gi 15233624   225 SVDYLTKPLEVFKEMNRILKPGG-LALMSFS 254
Cdd:pfam01209 120 GLRNFPDYLKVLKEAFRVLKPGGrVVCLEFS 150
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
188-253 4.40e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.37  E-value: 4.40e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15233624 188 EELKRNPVLTEYIVQDLNlnsNLPFEDNSFQVITNVVSVDYLTKPLEVFKEMNRILKPGGLALMSF 253
Cdd:COG4976  82 AKAREKGVYDRLLVADLA---DLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSV 144
arsM PRK11873
arsenite methyltransferase;
209-247 1.03e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 39.93  E-value: 1.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 15233624  209 NLPFEDNSFQVI-TNVV---SVDyltKPlEVFKEMNRILKPGG 247
Cdd:PRK11873 139 ALPVADNSVDVIiSNCVinlSPD---KE-RVFKEAFRVLKPGG 177
PRK08317 PRK08317
hypothetical protein; Provisional
 209-252 2.18e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 38.76  E-value: 2.18e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 15233624  209 NLPFEDNSFQVITNVVSVDYLTKPLEVFKEMNRILKPGGLALMS 252
Cdd:PRK08317  80 GLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVL 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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