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Conserved domains on  [gi|15236122|ref|NP_195172|]
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GTP binding protein beta 1 [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-369 2.63e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 250.33  E-value: 2.63e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  57 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 136
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 137 SstadkdgTVPVSRMLTGHRGYVSCCQYVPneDAHLITSSG-DQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISGS 215
Cdd:cd00200  81 E-------TGECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 216 npNWFISGSC-DSTARLWDTRAASRaVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHgdgeN 294
Cdd:cd00200 147 --GTFVASSSqDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH----E 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15236122 295 GPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLGlqqdSHRNRISCLGLSADGSALCTGSWDSNLKIWA 369
Cdd:cd00200 220 NGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGECVQTLS----GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-369 2.63e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 250.33  E-value: 2.63e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  57 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 136
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 137 SstadkdgTVPVSRMLTGHRGYVSCCQYVPneDAHLITSSG-DQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISGS 215
Cdd:cd00200  81 E-------TGECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 216 npNWFISGSC-DSTARLWDTRAASRaVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHgdgeN 294
Cdd:cd00200 147 --GTFVASSSqDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH----E 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15236122 295 GPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLGlqqdSHRNRISCLGLSADGSALCTGSWDSNLKIWA 369
Cdd:cd00200 220 NGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGECVQTLS----GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-368 8.61e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.90  E-value: 8.61e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  40 SAAQGRTRVSFGATDLVCCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNG 119
Cdd:COG2319  95 SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 120 QSVACGGLDSVCSIFSLSSTAdkdgtvpVSRMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWDVTTGLKTSVFGgef 199
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGK-------LLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLT--- 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 200 qsGHTADVLSVSISgSNPNWFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRT 279
Cdd:COG2319 244 --GHSGSVRSVAFS-PDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT 319

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 280 GHQLQVYQPHGDgengPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTG 359
Cdd:COG2319 320 GKLLRTLTGHTG----AVRSVAFSPDGKTLASG-SDDGTVRLWDLATGELLRTL----TGHTGAVTSVAFSPDGRTLASG 390


                ....*....
gi 15236122 360 SWDSNLKIW 368
Cdd:COG2319 391 SADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 241-276 1.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15236122    241 VRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYD 276
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
241-276 2.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15236122   241 VRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYD 276
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 246-367 1.06e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  246 GHEGDVNTVKFFP-DGYRFGTGSDDGTCRLYDIRT-GHQLQVYQP--HGDGENGPVTSIAFSVSGRLLFAGYASNNTCYV 321
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEeGLTQNISDPivHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 15236122  322 WDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTGSWDSNLKI 367
Cdd:PTZ00421 153 WDVERGKAVEVI----KCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-369 2.63e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 250.33  E-value: 2.63e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  57 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 136
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 137 SstadkdgTVPVSRMLTGHRGYVSCCQYVPneDAHLITSSG-DQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISGS 215
Cdd:cd00200  81 E-------TGECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 216 npNWFISGSC-DSTARLWDTRAASRaVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHgdgeN 294
Cdd:cd00200 147 --GTFVASSSqDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH----E 219

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15236122 295 GPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLGlqqdSHRNRISCLGLSADGSALCTGSWDSNLKIWA 369
Cdd:cd00200 220 NGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGECVQTLS----GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-368 8.61e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.90  E-value: 8.61e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  40 SAAQGRTRVSFGATDLVCCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNG 119
Cdd:COG2319  95 SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 120 QSVACGGLDSVCSIFSLSSTAdkdgtvpVSRMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWDVTTGLKTSVFGgef 199
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGK-------LLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLT--- 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 200 qsGHTADVLSVSISgSNPNWFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRT 279
Cdd:COG2319 244 --GHSGSVRSVAFS-PDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT 319

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 280 GHQLQVYQPHGDgengPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTG 359
Cdd:COG2319 320 GKLLRTLTGHTG----AVRSVAFSPDGKTLASG-SDDGTVRLWDLATGELLRTL----TGHTGAVTSVAFSPDGRTLASG 390


                ....*....
gi 15236122 360 SWDSNLKIW 368
Cdd:COG2319 391 SADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
34-368 1.04e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 1.04e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  34 TDVARYSAAQGRTRVSFGATDLVCCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTC 113
Cdd:COG2319  47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 114 AFSPNGQSVACGGLDSVCSIFSLSSTAdkdgtvpVSRMLTGHRGYVSCCQYVPNeDAHLITSSGDQTCILWDVTTGLKTS 193
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLATGK-------LLRTLTGHSGAVTSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLR 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 194 VFggefqSGHTADVLSVSISgSNPNWFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCR 273
Cdd:COG2319 199 TL-----TGHTGAVRSVAFS-PDGKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 274 LYDIRTGHQLQVYQPHgdgeNGPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLglqqDSHRNRISCLGLSADG 353
Cdd:COG2319 272 LWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASG-SDDGTVRLWDLATGKLLRTL----TGHTGAVRSVAFSPDG 342

                       330
                ....*....|....*
gi 15236122 354 SALCTGSWDSNLKIW 368
Cdd:COG2319 343 KTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
59-324 4.61e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.79  E-value: 4.61e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  59 RTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSLSs 138
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA- 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 139 tadkdgTVPVSRMLTGHRGYVSCCQYVPNeDAHLITSSGDQTCILWDVTTGLKTSVFGgefqsGHTADVLSVSISGsNPN 218
Cdd:COG2319 235 ------TGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTLT-----GHSGGVNSVAFSP-DGK 301

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 219 WFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHGdgenGPVT 298
Cdd:COG2319 302 LLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT----GAVT 376

                       250       260
                ....*....|....*....|....*.
gi 15236122 299 SIAFSVSGRLLFAGyASNNTCYVWDT 324
Cdd:COG2319 377 SVAFSPDGRTLASG-SADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
57-279 2.06e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.76  E-value: 2.06e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  57 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 136
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 137 SSTAdkdgtvpVSRMLTGHRGYVSCCQYVPNeDAHLITSSGDQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISgSN 216
Cdd:COG2319 276 ATGE-------LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTL-----TGHTGAVRSVAFS-PD 341

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15236122 217 PNWFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRT 279
Cdd:COG2319 342 GKTLASGSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-376 7.67e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 7.67e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 149 SRMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISGSNpNWFISGSCDST 228
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTL-----KGHTGPVRDVAASADG-TYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 229 ARLWDTRAaSRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHgdgeNGPVTSIAFSVSGRL 308
Cdd:cd00200  75 IRLWDLET-GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH----TDWVNSVAFSPDGTF 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15236122 309 LFagyasnntcyvwdtllgevvldlglqqdshrnrisclglsadgsalcTGSWDSNLKIWAFGGHRRV 376
Cdd:cd00200 150 VA-----------------------------------------------SSSQDGTIKLWDLRTGKCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
182-368 4.04e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 4.04e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 182 ILWDVTTGLKTSVFGGEFQSGHTADVLSVSISGSNPNWFISGSCDSTARLWDTRAASRAVRTFHGHEGDVNTVKFFPDGY 261
Cdd:COG2319  12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122 262 RFGTGSDDGTCRLYDIRTGHQLQVYQPHGDgengPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLglqqDSHR 341
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASG-SADGTVRLWDLATGKLLRTL----TGHS 162

                       170       180
                ....*....|....*....|....*..
gi 15236122 342 NRISCLGLSADGSALCTGSWDSNLKIW 368
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 241-276 1.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15236122    241 VRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYD 276
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-93 2.70e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 15236122     57 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWN 93
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
241-276 2.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15236122   241 VRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYD 276
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
57-93 2.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15236122    57 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWN 93
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-93 3.99e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 3.99e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15236122  56 VCCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWN 93
Cdd:cd00200 252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 246-367 1.06e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  246 GHEGDVNTVKFFP-DGYRFGTGSDDGTCRLYDIRT-GHQLQVYQP--HGDGENGPVTSIAFSVSGRLLFAGYASNNTCYV 321
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEeGLTQNISDPivHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 15236122  322 WDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTGSWDSNLKI 367
Cdd:PTZ00421 153 WDVERGKAVEVI----KCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 110-360 2.89e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  110 VMTCAFSPNGQSVACGGLDSVCSIFSLSSTAD--KDGTVPVSRmLTGHRGYVSCC--QYVPNEDAhliTSSGDQTCILWD 185
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKdgRDIHYPVVE-LASRSKLSGICwnSYIKSQVA---SSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  186 VT-TGLKTSVfggefqSGHTADVLSVSISGSNPNWFISGSCDSTARLWDTRAASR--AVRTfhghEGDVNTVKFFPD-GY 261
Cdd:PLN00181 562 VArSQLVTEM------KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSigTIKT----KANICCVQFPSEsGR 631

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  262 RFGTGSDDGTCRLYDIRTGhqlQVYQPHGDGENGPVTSIAFSVSGRLLFAgyASNNTCYVWDTLLGEVvldlGLQQD--- 338
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNP---KLPLCTMIGHSKTVSYVRFVDSSTLVSS--STDNTLKLWDLSMSIS----GINETplh 702

                        250       260
                 ....*....|....*....|....*
gi 15236122  339 ---SHRNRISCLGLSADGSALCTGS 360
Cdd:PLN00181 703 sfmGHTNVKNFVGLSVSDGYIATGS 727
WD40 COG2319
WD40 repeat [General function prediction only];
40-94 3.38e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 3.38e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15236122  40 SAAQGRTRVSFGATDLVCCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNA 94
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 pfam00400
WD domain, G-beta repeat;
201-233 4.11e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.11e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15236122   201 SGHTADVLSVSISgSNPNWFISGSCDSTARLWD 233
Cdd:pfam00400   8 EGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 135-280 4.47e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.19  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122  135 SLSSTA----DKDGTVPVSR-MLTGHRGYVSCCQYVPNEDAHLITSSGDQTCILWDV-TTGLKTSVFGG--EFQsGHTAD 206
Cdd:PTZ00421  49 QLGSTAvlkhTDYGKLASNPpILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpEEGLTQNISDPivHLQ-GHTKK 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15236122  207 VLSVSISGSNPNWFISGSCDSTARLWDTRAAsRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTG 280
Cdd:PTZ00421 128 VGIVSFHPSAMNVLASAGADMVVNVWDVERG-KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-233 1.70e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.70e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15236122    201 SGHTADVLSVSISGSNpNWFISGSCDSTARLWD 233
Cdd:smart00320   9 KGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-185 2.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.12e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15236122    150 RMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWD 185
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 266-348 2.40e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15236122   266 GSDDGTCRLYdiRTGHQlQVYQPHGDGENGPVTSIAFSVSGRLLFAGYaSNNTCYVWDTLLGEVVLDLglqqDSHRNRIS 345
Cdd:pfam12894  13 ATEDGELLLH--RLNWQ-RVWTLSPDKEDLEVTSLAWRPDGKLLAVGY-SDGTVRLLDAENGKIVHHF----SAGSDLIT 84


                  ...
gi 15236122   346 CLG 348
Cdd:pfam12894  85 CLG 87
WD40 pfam00400
WD domain, G-beta repeat;
340-368 3.22e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 15236122   340 HRNRISCLGLSADGSALCTGSWDSNLKIW 368
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
150-185 3.84e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15236122   150 RMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWD 185
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 338-368 4.94e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 15236122    338 DSHRNRISCLGLSADGSALCTGSWDSNLKIW 368
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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