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Conserved domains on  [gi|42567412|ref|NP_195264|]
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SEC7-like guanine nucleotide exchange family protein [Arabidopsis thaliana]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1705 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1919.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    11 TRCGRIIGPSLDKIIKNAAWRKHTYLVSSCKSVLDKLESLP---------DDFHDPSSVVSG---------LAASDADSV 72
Cdd:PLN03076    8 SRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEknppstssaAADSASASSLPGplhdggsieYSLAESELI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    73 LQPFLLSLETAYSKVVEPSLDCAFKLFSLSILRGEIQSSKQDS--ILFKLVNAVSKVGAIAEEPIQLAVLRVLLAAVRSP 150
Cdd:PLN03076   88 LSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEalLLAKLIESVCKCHDLGDEGIELLVLKTLLSAVTST 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   151 CILIRGDCLLHVVKTCYNIYLGGLSGTTQICAKSVLAQMMLVIFTRSEEDSLDVSVKTIYVNELLTFTDKSVNEGSSVYF 230
Cdd:PLN03076  168 SLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKSDSDTSMTQF 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   231 CQGFVNEVMAAGQG--SPLPPPDVIQILLQNPETETVMTPDSPS-----------------------------FRGYVAN 279
Cdd:PLN03076  248 VQGFITKIMQDIDGvlNPATAGKSSGSGAHDGAFETTATVETTNpadlldstdkdmldakyweismyksalegRKGELAD 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   280 GE----GDSETGDMSKVRQDAFLLFKNLCKLSMRFSSKENNDDQIMVRGKTLSLELLKVIIDNGGSVWRTNESFINAVKQ 355
Cdd:PLN03076  328 GEvekdDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRTSDRFLGAIKQ 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   356 YLCLSLLKNSAVSIMSIFQLQCAIFMSLLSKLRSVLKAEIGIFFPMIVLRVLENVLQPSYLQKMTVLNLLDKMSQDPQLM 435
Cdd:PLN03076  408 YLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLDKLCVDSQIL 487

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   436 VDIFVNYDCDVESSNILERIVNGLLKTALGPPTGSSTTLSPAQDSTFRNDSVKCLVNLAKAMGNWMDQQLKVNETVWPKG 515
Cdd:PLN03076  488 VDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPASLKK 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   516 -SQVYASMDSNASQISE--LEGTISDCDSQPDTSNpEAYDASMLEQRRAYKIELQKGISLFNRKPSKGVEFLISTKKIGS 592
Cdd:PLN03076  568 lDAVENNLEPGSLPVANgnGDENGEGSDSHSELSS-ETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGE 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   593 SPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEKKDFVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHY 672
Cdd:PLN03076  647 SPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERY 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   673 WKCNPGSFTSADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVRNNRGIDDGKDLPEEYLGSLYDRVVKEEIRMNSDTLA 752
Cdd:PLN03076  727 CKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDDLV 806

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   753 PQNKQVNGLNKLLGLDGILNLVSWMQPDEKPHGANGRLIRDIQEQFQAKPEKSESVYHTVTDISILRFILEVSWGPMLAA 832
Cdd:PLN03076  807 PQQKQSANSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAA 886

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   833 FSVTIDQSDDRLATSLCLQGFRYAVHVTAVMGMQTQRDAFVTSMAKFTNLHCAADMKQKNVDAVKAIITIAIEDGNHLHG 912
Cdd:PLN03076  887 FSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADEDGNYLQE 966

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   913 SWEHILTCLSRIEHLQLLGEVSPSEKRYVPTKKAEVDDKKALG---FPNLKKRGSFQNPSVMAVVRGGSYDSTSLVKSVP 989
Cdd:PLN03076  967 AWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKspiLPVLKRKGPGKLQYAAAAVRRGSYDSAGVGGKAS 1046

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   990 KLVTPEQIKSFIANLNLLDQIGNFELNHVYANSQRLNSEAIVSFVKALCKVSMSELQSPTDPRVFSLTKLVETAHYNMNR 1069
Cdd:PLN03076 1047 GVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNR 1126

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1070 IRLVWSRIWNVLSDFFVSVGLSENLSVAIFVMDSLRQLSMKFLEREELANYHFQHEFLRPFVVVMQKSSSAEIRELIVRC 1149
Cdd:PLN03076 1127 IRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRC 1206

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1150 VSQMVLSRVSNVKSGWKNVFTVFTTAALDERKNIVLLAFETIEKIVRDHFHCIIETEITVYADCIRCLITFTNSKFEGDI 1229
Cdd:PLN03076 1207 VSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDI 1286

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1230 GFNTIEFLRFCALKLEEGGL---VLNEKLKNNTIS--ALKEDFSDTQSFTDLDEQVSYWIPLLTGLCKQVSDPRPAIRKR 1304
Cdd:PLN03076 1287 SLNAIAFLRFCATKLAEGDLgssSRNKDKEAPPSSpqSGKDGKQESGEFTDKDDHLYFWFPLLAGLSELSFDPRPEIRKS 1366

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1305 SIEVLFHILMDHGHLFTRPFWTGIFSSIILPVFNNIRSKTDMLfEESVDSPSSASLDTEE---TTWDVETSTLALQLLVD 1381
Cdd:PLN03076 1367 ALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPS-GGDEPEGQGVDGDQGEldqDAWLYETCTLALQLVVD 1445

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1382 LLVKFFRSVRSQLPSVVSIIVGFIKSPFQGSTGSGISVLLHLADGLARSASEDEWREIFLALKEAASLTFAGFMKVL--- 1458
Cdd:PLN03076 1446 LFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVsge 1525

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1459 -RTMDDIEDVEtlSGQSVNIGDLDDDSLHIMS----YVVSRTKKHIDVLSQIVEVVSDLYRRNQFSLSASHVDILADIFS 1533
Cdd:PLN03076 1526 yMPAENIQDSE--NAEAASSSTADNDAEAERSrrlyAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSAKNTLVLFDALH 1603

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1534 CIASHAQQLNTDTVLRRKFKRACSVQNLTEPQLLNFENEAYKSYMMFLQDMVTCNPNVSKELDLESRLVTECAKIVKIYL 1613
Cdd:PLN03076 1604 TVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI 1683

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1614 K--CTDPQQQEQQQRKPvLWVLPMESDRVEEATARTSLLVSSLEALCSLEAESLKKHVSSFFPLLVDLVRTEHCSPQVPY 1691
Cdd:PLN03076 1684 EtsTAGQDSEDSSSQQP-RWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISCEHGSNEVQV 1762

                        1770
                  ....*....|....
gi 42567412  1692 VLSNVLKSCIGPIL 1705
Cdd:PLN03076 1763 ALSDMLSSWVGPVL 1776
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1705 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1919.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    11 TRCGRIIGPSLDKIIKNAAWRKHTYLVSSCKSVLDKLESLP---------DDFHDPSSVVSG---------LAASDADSV 72
Cdd:PLN03076    8 SRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEknppstssaAADSASASSLPGplhdggsieYSLAESELI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    73 LQPFLLSLETAYSKVVEPSLDCAFKLFSLSILRGEIQSSKQDS--ILFKLVNAVSKVGAIAEEPIQLAVLRVLLAAVRSP 150
Cdd:PLN03076   88 LSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEalLLAKLIESVCKCHDLGDEGIELLVLKTLLSAVTST 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   151 CILIRGDCLLHVVKTCYNIYLGGLSGTTQICAKSVLAQMMLVIFTRSEEDSLDVSVKTIYVNELLTFTDKSVNEGSSVYF 230
Cdd:PLN03076  168 SLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKSDSDTSMTQF 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   231 CQGFVNEVMAAGQG--SPLPPPDVIQILLQNPETETVMTPDSPS-----------------------------FRGYVAN 279
Cdd:PLN03076  248 VQGFITKIMQDIDGvlNPATAGKSSGSGAHDGAFETTATVETTNpadlldstdkdmldakyweismyksalegRKGELAD 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   280 GE----GDSETGDMSKVRQDAFLLFKNLCKLSMRFSSKENNDDQIMVRGKTLSLELLKVIIDNGGSVWRTNESFINAVKQ 355
Cdd:PLN03076  328 GEvekdDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRTSDRFLGAIKQ 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   356 YLCLSLLKNSAVSIMSIFQLQCAIFMSLLSKLRSVLKAEIGIFFPMIVLRVLENVLQPSYLQKMTVLNLLDKMSQDPQLM 435
Cdd:PLN03076  408 YLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLDKLCVDSQIL 487

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   436 VDIFVNYDCDVESSNILERIVNGLLKTALGPPTGSSTTLSPAQDSTFRNDSVKCLVNLAKAMGNWMDQQLKVNETVWPKG 515
Cdd:PLN03076  488 VDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPASLKK 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   516 -SQVYASMDSNASQISE--LEGTISDCDSQPDTSNpEAYDASMLEQRRAYKIELQKGISLFNRKPSKGVEFLISTKKIGS 592
Cdd:PLN03076  568 lDAVENNLEPGSLPVANgnGDENGEGSDSHSELSS-ETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGE 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   593 SPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEKKDFVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHY 672
Cdd:PLN03076  647 SPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERY 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   673 WKCNPGSFTSADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVRNNRGIDDGKDLPEEYLGSLYDRVVKEEIRMNSDTLA 752
Cdd:PLN03076  727 CKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDDLV 806

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   753 PQNKQVNGLNKLLGLDGILNLVSWMQPDEKPHGANGRLIRDIQEQFQAKPEKSESVYHTVTDISILRFILEVSWGPMLAA 832
Cdd:PLN03076  807 PQQKQSANSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAA 886

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   833 FSVTIDQSDDRLATSLCLQGFRYAVHVTAVMGMQTQRDAFVTSMAKFTNLHCAADMKQKNVDAVKAIITIAIEDGNHLHG 912
Cdd:PLN03076  887 FSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADEDGNYLQE 966

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   913 SWEHILTCLSRIEHLQLLGEVSPSEKRYVPTKKAEVDDKKALG---FPNLKKRGSFQNPSVMAVVRGGSYDSTSLVKSVP 989
Cdd:PLN03076  967 AWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKspiLPVLKRKGPGKLQYAAAAVRRGSYDSAGVGGKAS 1046

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   990 KLVTPEQIKSFIANLNLLDQIGNFELNHVYANSQRLNSEAIVSFVKALCKVSMSELQSPTDPRVFSLTKLVETAHYNMNR 1069
Cdd:PLN03076 1047 GVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNR 1126

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1070 IRLVWSRIWNVLSDFFVSVGLSENLSVAIFVMDSLRQLSMKFLEREELANYHFQHEFLRPFVVVMQKSSSAEIRELIVRC 1149
Cdd:PLN03076 1127 IRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRC 1206

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1150 VSQMVLSRVSNVKSGWKNVFTVFTTAALDERKNIVLLAFETIEKIVRDHFHCIIETEITVYADCIRCLITFTNSKFEGDI 1229
Cdd:PLN03076 1207 VSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDI 1286

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1230 GFNTIEFLRFCALKLEEGGL---VLNEKLKNNTIS--ALKEDFSDTQSFTDLDEQVSYWIPLLTGLCKQVSDPRPAIRKR 1304
Cdd:PLN03076 1287 SLNAIAFLRFCATKLAEGDLgssSRNKDKEAPPSSpqSGKDGKQESGEFTDKDDHLYFWFPLLAGLSELSFDPRPEIRKS 1366

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1305 SIEVLFHILMDHGHLFTRPFWTGIFSSIILPVFNNIRSKTDMLfEESVDSPSSASLDTEE---TTWDVETSTLALQLLVD 1381
Cdd:PLN03076 1367 ALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPS-GGDEPEGQGVDGDQGEldqDAWLYETCTLALQLVVD 1445

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1382 LLVKFFRSVRSQLPSVVSIIVGFIKSPFQGSTGSGISVLLHLADGLARSASEDEWREIFLALKEAASLTFAGFMKVL--- 1458
Cdd:PLN03076 1446 LFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVsge 1525

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1459 -RTMDDIEDVEtlSGQSVNIGDLDDDSLHIMS----YVVSRTKKHIDVLSQIVEVVSDLYRRNQFSLSASHVDILADIFS 1533
Cdd:PLN03076 1526 yMPAENIQDSE--NAEAASSSTADNDAEAERSrrlyAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSAKNTLVLFDALH 1603

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1534 CIASHAQQLNTDTVLRRKFKRACSVQNLTEPQLLNFENEAYKSYMMFLQDMVTCNPNVSKELDLESRLVTECAKIVKIYL 1613
Cdd:PLN03076 1604 TVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI 1683

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1614 K--CTDPQQQEQQQRKPvLWVLPMESDRVEEATARTSLLVSSLEALCSLEAESLKKHVSSFFPLLVDLVRTEHCSPQVPY 1691
Cdd:PLN03076 1684 EtsTAGQDSEDSSSQQP-RWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISCEHGSNEVQV 1762

                        1770
                  ....*....|....
gi 42567412  1692 VLSNVLKSCIGPIL 1705
Cdd:PLN03076 1763 ALSDMLSSWVGPVL 1776
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 563-744 5.68e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 307.08  E-value: 5.68e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    563 KIELQKGISLFNRKPSKGVEFLISTKKIGSSPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEKKDFV 642
Cdd:pfam01369    2 KKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRID 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    643 EAIRFFLRGFRLPGEAQKIDRIMEKFAEHYWKCNPGSFTSADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVRNNRGID 722
Cdd:pfam01369   82 EALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGIN 161

                          170       180
                   ....*....|....*....|..
gi 42567412    723 DGKDLPEEYLGSLYDRVVKEEI 744
Cdd:pfam01369  162 DGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 562-744 1.20e-86

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 280.65  E-value: 1.20e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  562 YKIELQKGISLFNRKPSKGVEFLISTKKI-GSSPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEKKD 640
Cdd:cd00171    1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  641 FVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHYWKCNPGSFT-SADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVRNNR 719
Cdd:cd00171   81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSsSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                        170       180
                 ....*....|....*....|....*
gi 42567412  720 GIDDGKDLPEEYLGSLYDRVVKEEI 744
Cdd:cd00171  161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 560-744 1.87e-80

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 263.00  E-value: 1.87e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412     560 RAYKIELQKGISLFNRKPSKGVEFLISTKKIGS-SPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEK 638
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412     639 KDFVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHYWKCNPGSFT--SADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVR 716
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 42567412     717 NNRGIDDGKDLPEEYLGSLYDRVVKEEI 744
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1705 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1919.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    11 TRCGRIIGPSLDKIIKNAAWRKHTYLVSSCKSVLDKLESLP---------DDFHDPSSVVSG---------LAASDADSV 72
Cdd:PLN03076    8 SRLGKVVSPALEKIIKNASWRKHSKLAHECKAVIERLNSPEknppstssaAADSASASSLPGplhdggsieYSLAESELI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    73 LQPFLLSLETAYSKVVEPSLDCAFKLFSLSILRGEIQSSKQDS--ILFKLVNAVSKVGAIAEEPIQLAVLRVLLAAVRSP 150
Cdd:PLN03076   88 LSPLINACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEalLLAKLIESVCKCHDLGDEGIELLVLKTLLSAVTST 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   151 CILIRGDCLLHVVKTCYNIYLGGLSGTTQICAKSVLAQMMLVIFTRSEEDSLDVSVKTIYVNELLTFTDKSVNEGSSVYF 230
Cdd:PLN03076  168 SLRIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEADSSTVPIQPIVVAELMEPAEKSDSDTSMTQF 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   231 CQGFVNEVMAAGQG--SPLPPPDVIQILLQNPETETVMTPDSPS-----------------------------FRGYVAN 279
Cdd:PLN03076  248 VQGFITKIMQDIDGvlNPATAGKSSGSGAHDGAFETTATVETTNpadlldstdkdmldakyweismyksalegRKGELAD 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   280 GE----GDSETGDMSKVRQDAFLLFKNLCKLSMRFSSKENNDDQIMVRGKTLSLELLKVIIDNGGSVWRTNESFINAVKQ 355
Cdd:PLN03076  328 GEvekdDDLEVQIGNKLRRDAFLVFRALCKLSMKTPPKEALADPQLMRGKILALELLKILLENAGAVFRTSDRFLGAIKQ 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   356 YLCLSLLKNSAVSIMSIFQLQCAIFMSLLSKLRSVLKAEIGIFFPMIVLRVLENVLQPSYLQKMTVLNLLDKMSQDPQLM 435
Cdd:PLN03076  408 YLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPNFQQKMIVLRFLDKLCVDSQIL 487

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   436 VDIFVNYDCDVESSNILERIVNGLLKTALGPPTGSSTTLSPAQDSTFRNDSVKCLVNLAKAMGNWMDQQLKVNETVWPKG 515
Cdd:PLN03076  488 VDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPASLKK 567

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   516 -SQVYASMDSNASQISE--LEGTISDCDSQPDTSNpEAYDASMLEQRRAYKIELQKGISLFNRKPSKGVEFLISTKKIGS 592
Cdd:PLN03076  568 lDAVENNLEPGSLPVANgnGDENGEGSDSHSELSS-ETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGE 646

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   593 SPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEKKDFVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHY 672
Cdd:PLN03076  647 SPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERY 726

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   673 WKCNPGSFTSADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVRNNRGIDDGKDLPEEYLGSLYDRVVKEEIRMNSDTLA 752
Cdd:PLN03076  727 CKCNPKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEDDLV 806

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   753 PQNKQVNGLNKLLGLDGILNLVSWMQPDEKPHGANGRLIRDIQEQFQAKPEKSESVYHTVTDISILRFILEVSWGPMLAA 832
Cdd:PLN03076  807 PQQKQSANSNRILGLDSILNIVIRKRGEDSYMETSDDLIKHMQEQFKEKARKSESVYYAATDVVILRFMVEVCWAPMLAA 886

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   833 FSVTIDQSDDRLATSLCLQGFRYAVHVTAVMGMQTQRDAFVTSMAKFTNLHCAADMKQKNVDAVKAIITIAIEDGNHLHG 912
Cdd:PLN03076  887 FSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADIKQKNIDAIKAIVSIADEDGNYLQE 966

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   913 SWEHILTCLSRIEHLQLLGEVSPSEKRYVPTKKAEVDDKKALG---FPNLKKRGSFQNPSVMAVVRGGSYDSTSLVKSVP 989
Cdd:PLN03076  967 AWEHILTCVSRFEHLHLLGEGAPPDATFFAAPQNESDKSKQAKspiLPVLKRKGPGKLQYAAAAVRRGSYDSAGVGGKAS 1046

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   990 KLVTPEQIKSFIANLNLLDQIGNFELNHVYANSQRLNSEAIVSFVKALCKVSMSELQSPTDPRVFSLTKLVETAHYNMNR 1069
Cdd:PLN03076 1047 GVVTSEQMNNLVSNLNMLEQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNR 1126

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1070 IRLVWSRIWNVLSDFFVSVGLSENLSVAIFVMDSLRQLSMKFLEREELANYHFQHEFLRPFVVVMQKSSSAEIRELIVRC 1149
Cdd:PLN03076 1127 IRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRC 1206

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1150 VSQMVLSRVSNVKSGWKNVFTVFTTAALDERKNIVLLAFETIEKIVRDHFHCIIETEITVYADCIRCLITFTNSKFEGDI 1229
Cdd:PLN03076 1207 VSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDI 1286

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1230 GFNTIEFLRFCALKLEEGGL---VLNEKLKNNTIS--ALKEDFSDTQSFTDLDEQVSYWIPLLTGLCKQVSDPRPAIRKR 1304
Cdd:PLN03076 1287 SLNAIAFLRFCATKLAEGDLgssSRNKDKEAPPSSpqSGKDGKQESGEFTDKDDHLYFWFPLLAGLSELSFDPRPEIRKS 1366

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1305 SIEVLFHILMDHGHLFTRPFWTGIFSSIILPVFNNIRSKTDMLfEESVDSPSSASLDTEE---TTWDVETSTLALQLLVD 1381
Cdd:PLN03076 1367 ALQVLFDTLRNHGHLFSLPLWERVFESVLFPIFDYVRHAIDPS-GGDEPEGQGVDGDQGEldqDAWLYETCTLALQLVVD 1445

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1382 LLVKFFRSVRSQLPSVVSIIVGFIKSPFQGSTGSGISVLLHLADGLARSASEDEWREIFLALKEAASLTFAGFMKVL--- 1458
Cdd:PLN03076 1446 LFVKFYPTVNPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVsge 1525

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1459 -RTMDDIEDVEtlSGQSVNIGDLDDDSLHIMS----YVVSRTKKHIDVLSQIVEVVSDLYRRNQFSLSASHVDILADIFS 1533
Cdd:PLN03076 1526 yMPAENIQDSE--NAEAASSSTADNDAEAERSrrlyAAISDAKCRAAVQLLLIQAVMEIYNMYRPRLSAKNTLVLFDALH 1603

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1534 CIASHAQQLNTDTVLRRKFKRACSVQNLTEPQLLNFENEAYKSYMMFLQDMVTCNPNVSKELDLESRLVTECAKIVKIYL 1613
Cdd:PLN03076 1604 TVASHAHKINSDTALRSKLQELGSMTQMQDPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI 1683

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  1614 K--CTDPQQQEQQQRKPvLWVLPMESDRVEEATARTSLLVSSLEALCSLEAESLKKHVSSFFPLLVDLVRTEHCSPQVPY 1691
Cdd:PLN03076 1684 EtsTAGQDSEDSSSQQP-RWLIPLGSGKRRELAARAPLVVATLQAVCGLGDSSFEKNLVRFFPLLAGLISCEHGSNEVQV 1762

                        1770
                  ....*....|....
gi 42567412  1692 VLSNVLKSCIGPIL 1705
Cdd:PLN03076 1763 ALSDMLSSWVGPVL 1776
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 563-744 5.68e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 307.08  E-value: 5.68e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    563 KIELQKGISLFNRKPSKGVEFLISTKKIGSSPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEKKDFV 642
Cdd:pfam01369    2 KKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRID 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    643 EAIRFFLRGFRLPGEAQKIDRIMEKFAEHYWKCNPGSFTSADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVRNNRGID 722
Cdd:pfam01369   82 EALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPGVFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLRGIN 161

                          170       180
                   ....*....|....*....|..
gi 42567412    723 DGKDLPEEYLGSLYDRVVKEEI 744
Cdd:pfam01369  162 DGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 562-744 1.20e-86

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 280.65  E-value: 1.20e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  562 YKIELQKGISLFNRKPSKGVEFLISTKKI-GSSPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEKKD 640
Cdd:cd00171    1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412  641 FVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHYWKCNPGSFT-SADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVRNNR 719
Cdd:cd00171   81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPGIFSsSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNLR 160

                        170       180
                 ....*....|....*....|....*
gi 42567412  720 GIDDGKDLPEEYLGSLYDRVVKEEI 744
Cdd:cd00171  161 GINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 560-744 1.87e-80

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 263.00  E-value: 1.87e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412     560 RAYKIELQKGISLFNRKPSKGVEFLISTKKIGS-SPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEK 638
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412     639 KDFVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHYWKCNPGSFT--SADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVR 716
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSkaNADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 42567412     717 NNRGIDDGKDLPEEYLGSLYDRVVKEEI 744
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 293-447 1.34e-48

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 170.37  E-value: 1.34e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    293 RQDAFLLFKNLCKLS-MRFSSKENNDDQIMvRGKTLSLELLKVIIDNGGSVWRTNESFINAVKQYLCLSLLKNSAVSIMS 371
Cdd:pfam12783    2 AKDAFLVFRDLCKLSnGKPLSKSDPKSHAE-RSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSSFP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42567412    372 IFQLQCAIFMSLLSKLRSVLKAEIGIFFPMIVLRVLENVlqPSYLQKMTVLNLLDKMSQDPQLMVDIFVNYDCDVE 447
Cdd:pfam12783   81 VFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLESD--SSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1110-1193 1.02e-35

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 130.69  E-value: 1.02e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   1110 KFLEREELANYHFQHEFLRPFVVVMQKSSSAEIRELIVRCVSQMVLSRVSNVKSGWKNVFTVFTTAALDERKNIVLLAFE 1189
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ....
gi 42567412   1190 TIEK 1193
Cdd:pfam09324   81 ILEL 84
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1504-1698 1.07e-16

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 79.59  E-value: 1.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   1504 QIVEVVSDLYRRNQFSLSASHVDILADIFSCIASHAQQLNTDTVLRRKFKRACSVQNLtePQLLNFENEAYKSYMMFLQD 1583
Cdd:pfam20252    5 LLIQTVNEILDEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLELRTALWRAGFMKQL--PNLLKQETSSLSTYLRILFR 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   1584 MVtCNPNVSKEL--DLESRLVTECAKIVKIYLKCTdpqqqeqqqrkpvlwvlpmESDRVEEATARTSLLVSSLEALCSLE 1661
Cdd:pfam20252   83 LY-ADDEPRTSQreEVEERLIPLCEDILEYYLSLD-------------------EEEKQRELAAWTPVVVLILQGLLALP 142

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 42567412   1662 AESLKKHVSSFFPLLVDLVRTEHcSPQVPYVLSNVLK 1698
Cdd:pfam20252  143 DDDFRRHLPEFYPLLCDLILCEL-SPEVRLALREFFS 178
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 23-196 5.50e-16

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 77.30  E-value: 5.50e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412     23 KIIKNAAWRKHTYLVSSCKSVLDKLESLpddfHDPSSVVSGLAASDADsVLQPFLLSLETAYSKVVEPSLDCAFKLFSLS 102
Cdd:pfam16213   14 RTLSSEAKRKYPPVKEASEKGILRLRTV----HSSSPLMQNLLSASED-ILKPFVLACETKNPKLVQIALGCLQKLISHD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412    103 ILRGEiqssKQDSILFKLVNAVSkvgaiAEEPIQLAVLRVLLAAVRSPCIlIRGDCLLHVVKTCYNIYLGGlSGTTQICA 182
Cdd:pfam16213   89 AISQS----AAPYILDTLWMLME-----LGSEIELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLHFSK-DPTVQNTA 157

                          170
                   ....*....|....
gi 42567412    183 KSVLAQMMLVIFTR 196
Cdd:pfam16213  158 SATLRQLVSVVFER 171
Mon2_C pfam16206
C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and ...
 1283-1367 2.83e-07

C-terminal region of Mon2 protein; Mon2 proteins are found from fungi to plants, to human and is a scaffold protein involved in multiple aspects of endo membrane trafficking. This C-terminal region is essential for Mon2 activity.


Pssm-ID: 465066  Cd Length: 827  Bit Score: 55.51  E-value: 2.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42567412   1283 WIPLLTGLCKQVSDPRPAIRKRSIEVLFHILMDHGHLFTRPFWTGIFSSIILPVFNNIRSKTDMLFEESVDSPSSA---- 1358
Cdd:pfam16206   93 WLCLYAKLGELCVDLRPAVRKSAGQTLFSTIGAHGSLLNHPTWHALIWKVLFNLLDNVRALSSSADKEKIDAGGGNilih 172

                           90
                   ....*....|
gi 42567412   1359 -SLDTEETTW 1367
Cdd:pfam16206  173 hSRDTAEKQW 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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