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Conserved domains on  [gi|30691669|ref|NP_195515|]
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tRNA/rRNA methyltransferase (SpoU) family protein [Arabidopsis thaliana]

Protein Classification

TrmH family RNA methyltransferase( domain architecture ID 11426248)

TrmH family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

CATH:  3.40.1280.10
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:0032259|GO:0003723|GO:1904047|GO:0006396
PubMed:  11763972|18029778|17338813|30457841|8265370

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 69-346 8.95e-64

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 203.50  E-value: 8.95e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  69 ITSTTNPFVKHCLKLRQSSsYRHAHGSVLVVGTIPIREVcmFQTNKqgmttEIECLLLHEEA-----KIPQGLESLSIRI 143
Cdd:COG0566   1 MTSPSNPRVKDLRKLRDKK-YREEEGLFLAEGRHAVEEA--LKAGR-----EIEELLVTEGAldrlaELLALAKAAGIPV 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 144 VRVSSLVMKKLSGVQSTESVEAIALMRIPSSFTDLKDDKdiitdcnkwfPSAHRVLVLDSIQDPGNLGTLVRSAMAFNWD 223
Cdd:COG0566  73 YEVSREVLDKLSGTETHQGVLAVVRPPEYADLEDLLAEA----------GEPPLLLVLDGVQDPGNLGAILRSAAAFGVD 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 224 GAFLLPGCCDPYNDKALRASRGASFQLPIV-SGNWNHL--KLLENEFQMKLLAGHPATTtqklkpvsklsveFAQSLAEK 300
Cdd:COG0566 143 GVILPKRRADPYNPKVVRASAGALFHVPVArVTNLADAleELKEAGFWVVGTDLDGEAS-------------LYEVDLPG 209

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 30691669 301 PLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:COG0566 210 PVALVLGNEGKGLSRLVLEACdELVRIPMAGGVESLNVAVAAAILLY 256
 
Name Accession Description Interval E-value
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 69-346 8.95e-64

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 203.50  E-value: 8.95e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  69 ITSTTNPFVKHCLKLRQSSsYRHAHGSVLVVGTIPIREVcmFQTNKqgmttEIECLLLHEEA-----KIPQGLESLSIRI 143
Cdd:COG0566   1 MTSPSNPRVKDLRKLRDKK-YREEEGLFLAEGRHAVEEA--LKAGR-----EIEELLVTEGAldrlaELLALAKAAGIPV 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 144 VRVSSLVMKKLSGVQSTESVEAIALMRIPSSFTDLKDDKdiitdcnkwfPSAHRVLVLDSIQDPGNLGTLVRSAMAFNWD 223
Cdd:COG0566  73 YEVSREVLDKLSGTETHQGVLAVVRPPEYADLEDLLAEA----------GEPPLLLVLDGVQDPGNLGAILRSAAAFGVD 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 224 GAFLLPGCCDPYNDKALRASRGASFQLPIV-SGNWNHL--KLLENEFQMKLLAGHPATTtqklkpvsklsveFAQSLAEK 300
Cdd:COG0566 143 GVILPKRRADPYNPKVVRASAGALFHVPVArVTNLADAleELKEAGFWVVGTDLDGEAS-------------LYEVDLPG 209

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 30691669 301 PLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:COG0566 210 PVALVLGNEGKGLSRLVLEACdELVRIPMAGGVESLNVAVAAAILLY 256
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 197-348 2.74e-56

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 179.93  E-value: 2.74e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 197 RVLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPIVSGNwNHLKLLE--NEFQMKLLAG 274
Cdd:cd18095   1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASMGALFRLPIIRVD-DLEELLEelKEAGYKVVAA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30691669 275 HPatttqklkpvsKLSVEFAQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLYML 348
Cdd:cd18095  80 DL-----------DGGSSLYDLDLPKPVALVLGNEGNGLSDELLELCdKRVTIPMSGGVESLNVAVAAAILLYEL 143
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 196-346 2.08e-42

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 144.21  E-value: 2.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669   196 HRVLVLDSIQDPGNLGTLVRSAMAFNWDGAFLL-PGCCDPYNDKALRASRGASFQLPI-VSGNWNH-LKLLENEfQMKLL 272
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVePRSADPYNPKAIRASAGALFHLPLvVVDNLEEaLKDLKEA-GYAVV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30691669   273 AghpatTTQKLKPVSKLSVEfaqslaeKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:pfam00588  80 A-----TSLGGKSLYEIDFP-------KKVALVFGNEGTGLSNEVLELCdRLVRIPMSGDVESLNVAVAAAIALY 142
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 122-346 4.79e-28

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 109.36  E-value: 4.79e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669   122 ECLLLHEEAKIPQGL----ESLSIRIVRVSSlvmKKLSGVQSTESVEAIALMRIPSSFTDLKDDKDIITDCNKWFpsahr 197
Cdd:TIGR00186  20 VFILKGLESKRLKKLiqlaKKQGINIQLVDR---QKLDQLTKGGNHQGIAAKVKPILYKDLNDLYKTAKSKKQPF----- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669   198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPI--VSGNWNHLKLLENEFQMKLLAGH 275
Cdd:TIGR00186  92 LLILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLarVTNLSRTITKLKESGFWTVGTDL 171

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30691669   276 PATTTQKlkpvsklsvefaQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:TIGR00186 172 DAQDTLY------------QVKLTKPLALVVGNEGEGVSRLIKENCdFLIKIPMAGKVDSLNVSVAAGILLF 231
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
199-346 1.62e-10

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 60.75  E-value: 1.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  199 LVLDSIQDPGNLGTLVRSAmafnwDGAfllpGCCdpyndkALRASRGASFQL-PIVS----GNWNHLKLleneFQ----- 268
Cdd:PRK11181  98 LILDGVTDPHNLGACLRSA-----DAA----GVH------AVIVPKDRSAQLnATAKkvacGAAETVPL----IRvtnla 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  269 --MKLL----------AGHpATTTqklkpvsklsveFAQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESL 335
Cdd:PRK11181 159 rtMRMLqekniwivgtAGE-ADHT------------LYQSKLTGPLALVMGAEGEGMRRLTREHCdELISIPMAGSVSSL 225

                        170
                 ....*....|.
gi 30691669  336 NVSVAGGIFLY 346
Cdd:PRK11181 226 NVSVATGICLF 236
 
Name Accession Description Interval E-value
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 69-346 8.95e-64

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 203.50  E-value: 8.95e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  69 ITSTTNPFVKHCLKLRQSSsYRHAHGSVLVVGTIPIREVcmFQTNKqgmttEIECLLLHEEA-----KIPQGLESLSIRI 143
Cdd:COG0566   1 MTSPSNPRVKDLRKLRDKK-YREEEGLFLAEGRHAVEEA--LKAGR-----EIEELLVTEGAldrlaELLALAKAAGIPV 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 144 VRVSSLVMKKLSGVQSTESVEAIALMRIPSSFTDLKDDKdiitdcnkwfPSAHRVLVLDSIQDPGNLGTLVRSAMAFNWD 223
Cdd:COG0566  73 YEVSREVLDKLSGTETHQGVLAVVRPPEYADLEDLLAEA----------GEPPLLLVLDGVQDPGNLGAILRSAAAFGVD 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 224 GAFLLPGCCDPYNDKALRASRGASFQLPIV-SGNWNHL--KLLENEFQMKLLAGHPATTtqklkpvsklsveFAQSLAEK 300
Cdd:COG0566 143 GVILPKRRADPYNPKVVRASAGALFHVPVArVTNLADAleELKEAGFWVVGTDLDGEAS-------------LYEVDLPG 209

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 30691669 301 PLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:COG0566 210 PVALVLGNEGKGLSRLVLEACdELVRIPMAGGVESLNVAVAAAILLY 256
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 197-348 2.74e-56

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 179.93  E-value: 2.74e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 197 RVLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPIVSGNwNHLKLLE--NEFQMKLLAG 274
Cdd:cd18095   1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASMGALFRLPIIRVD-DLEELLEelKEAGYKVVAA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30691669 275 HPatttqklkpvsKLSVEFAQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLYML 348
Cdd:cd18095  80 DL-----------DGGSSLYDLDLPKPVALVLGNEGNGLSDELLELCdKRVTIPMSGGVESLNVAVAAAILLYEL 143
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 196-346 2.08e-42

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 144.21  E-value: 2.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669   196 HRVLVLDSIQDPGNLGTLVRSAMAFNWDGAFLL-PGCCDPYNDKALRASRGASFQLPI-VSGNWNH-LKLLENEfQMKLL 272
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVePRSADPYNPKAIRASAGALFHLPLvVVDNLEEaLKDLKEA-GYAVV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30691669   273 AghpatTTQKLKPVSKLSVEfaqslaeKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:pfam00588  80 A-----TSLGGKSLYEIDFP-------KKVALVFGNEGTGLSNEVLELCdRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 198-346 5.98e-32

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 116.71  E-value: 5.98e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGaFLLP--GCCdPYNDKALRASRGASFQLPIV-SGNWNH-LKLL-ENEFQMKLL 272
Cdd:cd18103   2 LLILDGITDPHNLGAIIRSAEAFGVDG-VIIPkrRSA-PLTPTVAKASAGALEHLPIArVTNLARaLEELkEAGFWIYGA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30691669 273 AGHPATTTQKLKPvsklsvefaqslaEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:cd18103  80 DGEAEKSLYDVDL-------------TGPLALVLGSEGKGLRRLVLKNCdFLVKIPMAGKVDSLNVSVAAGIILY 141
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 197-348 1.56e-31

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 115.71  E-value: 1.56e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 197 RVLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPIVSGNWnhLKLLENEFQMK-----L 271
Cdd:cd18109   1 LTLALDGIQDPGNLGTIIRTADWFGIRQIICSPDTVDPYNPKVVQASMGSIFRVQIHYTDL--PALLAELKKAFpvygaD 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30691669 272 LAGHPATTTQKlkpvsklsvefaqslaEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDF-ESLNVSVAGGIFLYML 348
Cdd:cd18109  79 LDGENLYEFTL----------------PEKGILVMGNEGHGISPEVLKLLtHRLTIPRYGKGaESLNVAVATAILLSEF 141
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 198-346 2.38e-31

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 115.37  E-value: 2.38e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPIVSG------NWnhlkLLENEFQmkL 271
Cdd:cd18104   2 ILVLEGLEKPGNLGAILRSADAAGADAVILCDPKTDLFNPNVIRASLGAVFTLPVAEAsseetlAW----LKENKIR--I 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30691669 272 LAGHPatttqklkpvsKLSVEFAQSLAEKPLCLILGSEGNGLSEQARK-VCVLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:cd18104  76 LATTP-----------KAEKLYYEADLRGPIAIVVGSESEGLSEFWLKaADERVRIPMAGQADSLNVSVAAAILLY 140
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 198-346 2.51e-31

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 115.40  E-value: 2.51e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPIVsgnwnHLKLLENEFQMKLLAGHP- 276
Cdd:cd18082   1 HLVLDNIRSPGNIGSIFRTADAFGVEKIYLVGPTADIFDPKAKRTSRGTHFSVPYE-----RVDNFEEYLKSLKEEGYPl 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30691669 277 --ATTTQKLKPVSKLSVEFaqslaEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:cd18082  76 igLELTDGSIPLSEFKFKK-----PKKIALIFGNERSGLSPELLALCdYTVHIPMSGKNSSLNVSVATGIALY 143
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 199-346 5.13e-29

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 109.26  E-value: 5.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 199 LVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPIVSG-NWNHL-KLLENEFQMkLLAghp 276
Cdd:cd18106   3 VICDNIRDPGNLGSILRSAAAAGCSKVLLTKGCVDPWEPKVLRAGAGAHFRLPIYGNlSWDDIpNYLPDDSKV-FLA--- 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30691669 277 attTQKLKPVSKLSVEFAQslaeKPLCLILGSEGNGLSEQARKVCVL-----VSIPMAGDFESLNVSVAGGIFLY 346
Cdd:cd18106  79 ---DNNLPVQPYDSIDYCS----GPIVLVIGGETHGVSPEAYKLAHStggsrVHIPLANGVDSLNSAVAASILLF 146
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 122-346 4.79e-28

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 109.36  E-value: 4.79e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669   122 ECLLLHEEAKIPQGL----ESLSIRIVRVSSlvmKKLSGVQSTESVEAIALMRIPSSFTDLKDDKDIITDCNKWFpsahr 197
Cdd:TIGR00186  20 VFILKGLESKRLKKLiqlaKKQGINIQLVDR---QKLDQLTKGGNHQGIAAKVKPILYKDLNDLYKTAKSKKQPF----- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669   198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPI--VSGNWNHLKLLENEFQMKLLAGH 275
Cdd:TIGR00186  92 LLILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSSGAVEYVPLarVTNLSRTITKLKESGFWTVGTDL 171

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30691669   276 PATTTQKlkpvsklsvefaQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:TIGR00186 172 DAQDTLY------------QVKLTKPLALVVGNEGEGVSRLIKENCdFLIKIPMAGKVDSLNVSVAAGILLF 231
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 198-346 5.38e-23

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 93.22  E-value: 5.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPIV--SGNWNHLKLLENE----FQMKL 271
Cdd:cd18107   2 VVLFDRPTSPGNLGTIIRSADALGAHGLVVTGHAADVYDPKTIRASTGSLFSLPIVrvPSNRELEDWVEARkargTPLQL 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30691669 272 LAghpaTTTQKlkpvsklSVEFAQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:cd18107  82 VG----TDEHG-------DHQIADHDFTRPTLLLIGNETAGLSAAWRELCdETVSIPMAGSASSLNAACAASIFLY 146
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 198-346 9.33e-23

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 92.97  E-value: 9.33e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFQLPIVSGNwNHLKLL----ENEFqmKLLA 273
Cdd:cd18105   2 WLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVD-NLASFLksskENGW--KVVG 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30691669 274 GHPATTTQKLKPVSKlSVEFAQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFE-----SLNVSVAGGIFLY 346
Cdd:cd18105  79 TSAPPSASSDKKTIP-ANELSELLLEKPTILVLGNEGRGLRTNIKNLCdYLVSIPGGRSAEnpgvdSLNVSVAAGILLH 156
SpoU-like_NHR cd18108
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ...
 198-346 1.05e-19

Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349981  Cd Length: 144  Bit Score: 84.07  E-value: 1.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKAL-RASRGASFQLPIV-SGNWNHLKLLENEfQMKLLagh 275
Cdd:cd18108   2 VVVLDGVRIVGNIGAIVRTSLALGAAGIVLVDSDLATVADRRLlRASRGYVFSLPVVlADREEAVAFLRDN-DIPLM--- 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30691669 276 patttqKLKPVSKLSVEFAQSLAEkPLCLILGSEGNGLSEQ-ARKVCVLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:cd18108  78 ------TLDADGDVPVKELGDRPD-RLALVFGSEKGGPSGLfEEAAAGTVSIPMSSSTESLNVSVSAGIALH 142
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 198-349 1.18e-16

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 76.35  E-value: 1.18e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLpgccdpYNDKALRASRGASfqlpIVSGNW-------------NHLKlle 264
Cdd:cd18092  18 TVVLENVHDPHNASAVLRTCDAFGVQDVHVI------EPKNKFKKNRGVA----MGADKWldvhrhdsteeclAALK--- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 265 nEFQMKLLAGHPatttqklkpvSKLSVEFAQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGI 343
Cdd:cd18092  85 -EQGYRIVATSL----------SPDAVPLDELDYTRPTALVFGNEKDGVSEEALAAAdERVYIPMYGFVESLNVSVAAAI 153


                ....*.
gi 30691669 344 FLYMLQ 349
Cdd:cd18092 154 ILYELQ 159
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 198-346 2.89e-13

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 66.43  E-value: 2.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLlpgCCD---PYNDKALRASRGASFQLPivsgnWNHLKllenefqmkllag 274
Cdd:cd18097   2 VVVLDNLRSAHNVGSIFRTADAAGVEKIYL---CGYtptPPHPKVAKTALGAEESVP-----WEHFE------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 275 HPATTTQKLKP---------VSKLSVEFAQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIF 344
Cdd:cd18097  61 DTLEAVRALKArgytiialeTTENSVPLHEARLPRPLALVLGNEVRGVSPEVLALCdAVVEIPMFGRKNSLNVAVAAAVA 140


                ..
gi 30691669 345 LY 346
Cdd:cd18097 141 LY 142
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
199-346 1.62e-10

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 60.75  E-value: 1.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  199 LVLDSIQDPGNLGTLVRSAmafnwDGAfllpGCCdpyndkALRASRGASFQL-PIVS----GNWNHLKLleneFQ----- 268
Cdd:PRK11181  98 LILDGVTDPHNLGACLRSA-----DAA----GVH------AVIVPKDRSAQLnATAKkvacGAAETVPL----IRvtnla 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  269 --MKLL----------AGHpATTTqklkpvsklsveFAQSLAEKPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESL 335
Cdd:PRK11181 159 rtMRMLqekniwivgtAGE-ADHT------------LYQSKLTGPLALVMGAEGEGMRRLTREHCdELISIPMAGSVSSL 225

                        170
                 ....*....|.
gi 30691669  336 NVSVAGGIFLY 346
Cdd:PRK11181 226 NVSVATGICLF 236
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 198-346 3.38e-10

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 57.61  E-value: 3.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLLpgccdpyndkalrASRGASFQLPIVSGNWNHLKLLENEFQMKLLAghpa 277
Cdd:cd18096   2 YLVLHNVAKRHNIGTIVRSANAFGVKEVHLV-------------GRRKFNPFGAMGTDRHVKFRHFDTLAEAKEYL---- 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30691669 278 tTTQKLKPVSKLSVEFAQSLAEKPL----CLILGSEGNGLSEQARKVCV-LVSIPMAGDF-ESLNVSVAGGIFLY 346
Cdd:cd18096  65 -KERGIRLVGVEIVPGAEPIETHPFpgdtAFVLGNEGTGLSDEQLAICDgFVYIPQYGSGtASLNVSVAASIVLH 138
PRK10864 PRK10864
putative methyltransferase; Provisional
 198-345 4.96e-10

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 60.18  E-value: 4.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  198 VLVLDSIQDPGNLGTLVRSAMAFNWDGAFLlpgccdpyNDKALRASrGASFQlpIVSGNWNHLKLLENEFQMKLL----- 272
Cdd:PRK10864 200 VLALEDVGNPHNLGGIMRSCAHFGVKGVVV--------QDAALLES-GAAIR--TAEGGAEHVQPITGDSFVDVLddfrq 268

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30691669  273 AGHPATTTQKLKPVSKLSVEfaqsLAEKpLCLILGSEGNGLSEQARKVCVL-VSIPMAGDFESLNVSVAGGIFL 345
Cdd:PRK10864 269 AGYTIVTTSSHKGTPLFKAS----LPAK-MVLVLGQEYDGLSDAARQQGDLsVSIDGTGNVESLNVSVATGVLL 337
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 198-348 2.14e-09

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 55.58  E-value: 2.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 198 VLVldSIQDPGNLGTLVRSAMAFNWDGAFLLPGCCDPYNDKALRASRGASFqlpivsgnwnhlkLLENefqMKL------ 271
Cdd:cd18093   4 VLV--EPQHPGNIGAVARAMKNFGLSDLRLVNPRCDDPEEAARALASGAED-------------VLEN---AKVydtlee 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 272 -LAGHP---ATT--TQKLKPVSKLSVEFAQSLAE----KPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVA 340
Cdd:cd18093  66 aLADCDlvvATTarPRGLRRPLLTPRELAELLKEhaagGKVALVFGREDSGLTNEELALCdLLVTIPTNPEYPSLNLAQA 145


                ....*...
gi 30691669 341 GGIFLYML 348
Cdd:cd18093 146 VAIVLYEL 153
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 269-349 9.38e-08

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 52.30  E-value: 9.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669  269 MKLLAGHpatttqklkpVSKLSVEFAQSLAEKPLCLILGSEGNGLSEQARKVCVL-VSIPMAGDFESLNVSVAGGIFLYM 347
Cdd:PRK11081  91 MQILATH----------LSDTAVDFREIDYTRPTCILMGQEKTGISQEALALADQdIIIPMIGMVQSLNVSVASALILYE 160


                 ..
gi 30691669  348 LQ 349
Cdd:PRK11081 161 AQ 162
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 206-346 1.57e-06

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 46.87  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 206 DPGNLGTLVRSAMAFNWDGAFllpgccdpYNDKALRASRGASfqlpIVSGNWNHLKLLENEfQMKLLAGHPATTTqklKP 285
Cdd:cd18098  10 TPKNVGTLWRAAGCLGASFVF--------TIGARYKRRKQST----DTSKAWRHIPLFHYD-DLEDLAEPLPFGA---VL 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30691669 286 VSKLSVEFAQSLA--EKPL--CLILGSEGNGLSEQARKVC-VLVSIPMAGdfeSLNVSVAGGIFLY 346
Cdd:cd18098  74 VAVELTEGATPLPdfKHPDraVYLLGPEDGGLPQEVLARChHVVYLPTRG---SLNVAVAGSIVLY 136
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 199-346 1.39e-05

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 44.37  E-value: 1.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 199 LVLDSIQDPGNLGTLVRSAMAFNWD-------GaFLLpgccdpyNDKAL-RAsrGASFqlpivsgnWNHLKLLE----NE 266
Cdd:cd18094   2 IVLYEPEIPQNTGNIARTCAATGARlhlieplG-FSL-------DDKRLkRA--GLDY--------WDHVDLTVhdswEA 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30691669 267 FqmklLAGHP-----ATTTQKLKPVSKlsVEFaqslaEKPLCLILGSEGNGLSEQARKVC--VLVSIPMAGDFESLNVSV 339
Cdd:cd18094  64 F----LEALPpgrlfLFTTKGTKPYTD--FDF-----KPGDYLVFGRESTGLPEEILDAFpdRRLRIPMRPKVRSLNLSN 132


                ....*..
gi 30691669 340 AGGIFLY 346
Cdd:cd18094 133 SVAIVLY 139
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 300-346 4.61e-05

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 42.90  E-value: 4.61e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30691669 300 KPLCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:cd18091  96 KKTVLVLGNEKEGIPAELLSLLdVCVEIPQLGVIRSLNVHVSGAIAIY 143
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 292-346 4.96e-04

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 40.87  E-value: 4.96e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30691669 292 EFAQSLAE----KPLCLILGSEGNGLS--EQARkvC-VLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:COG0565  94 EAAEELLAraagGKVALVFGRERSGLTneELAL--CdALVTIPTNPEYPSLNLAQAVQVVAY 153
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 304-346 3.70e-03

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 37.32  E-value: 3.70e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 30691669 304 LILGSEGNGLSEQ--ARKVCVLVSIPMAGDFESLNVSVAGGIFLY 346
Cdd:COG0219  97 LLFGRETAGLPEEvlAAPADQRLRIPMRPGVRSLNLSNAVAIVLY 141
PRK10433 PRK10433
putative RNA methyltransferase; Provisional
 292-351 5.49e-03

putative RNA methyltransferase; Provisional


Pssm-ID: 236693  Cd Length: 228  Bit Score: 37.66  E-value: 5.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30691669  292 EFAQSLAEKP-----LCLILGSEGNGLSEQARKVC-VLVSIPMAGDFESLNVSVAGGIFLYMLQNL 351
Cdd:PRK10433  93 ELVPLLEEKSswmshAALVFGREDSGLTNEELALAdVLTGVPMAADYPSLNLGQAVMVYCYQLAGL 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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