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Conserved domains on  [gi|15241815|ref|NP_195863|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
405-721 4.28e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 4.28e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQeceimsmnegSLTPIHpSMSGSTDkssEGDAAEVSQDkkkkGK 484
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----------TGKLLR-TLTGHTG---AVRSVAFSPD----GK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 485 TsmskkgnqipdyvhapetVFSLSDkpicsftghlddvldlswsrsqlllsssmDKTVRLWDIETQSCLKLFA-HNDYVT 563
Cdd:COG2319 218 L------------------LASGSA-----------------------------DGTVRLWDLATGKLLRTLTgHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 564 CVQFNPlDEDYFISGSLDAKIRIWNISNRQVVE-WNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKLEQTnqid 642
Cdd:COG2319 251 SVAFSP-DGRLLASGSADGTVRLWDLATGELLRtLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT---- 325

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 643 lqnkKKAQAKKITAFQFSPiNPSEVLVTSADSRIRV--LDGTELVQKFRGFKnmNSQMTASYTVDAKHIVCASEDSQVYV 720
Cdd:COG2319 326 ----LTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHT--GAVTSVAFSPDGRTLASGSADGTVRL 398


                .
gi 15241815 721 W 721
Cdd:COG2319 399 W 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
405-721 4.28e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 4.28e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQeceimsmnegSLTPIHpSMSGSTDkssEGDAAEVSQDkkkkGK 484
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----------TGKLLR-TLTGHTG---AVRSVAFSPD----GK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 485 TsmskkgnqipdyvhapetVFSLSDkpicsftghlddvldlswsrsqlllsssmDKTVRLWDIETQSCLKLFA-HNDYVT 563
Cdd:COG2319 218 L------------------LASGSA-----------------------------DGTVRLWDLATGKLLRTLTgHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 564 CVQFNPlDEDYFISGSLDAKIRIWNISNRQVVE-WNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKLEQTnqid 642
Cdd:COG2319 251 SVAFSP-DGRLLASGSADGTVRLWDLATGELLRtLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT---- 325

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 643 lqnkKKAQAKKITAFQFSPiNPSEVLVTSADSRIRV--LDGTELVQKFRGFKnmNSQMTASYTVDAKHIVCASEDSQVYV 720
Cdd:COG2319 326 ----LTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHT--GAVTSVAFSPDGRTLASGSADGTVRL 398


                .
gi 15241815 721 W 721
Cdd:COG2319 399 W 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 405-722 3.02e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 3.02e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQECEIMSMNEGSLTPIHPSMSGSTDKSsegdAAEVSQDKKKKgk 484
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY----LASGSSDKTIR-- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 485 tsmskkgnqipdyvhapetVFSLSD-KPICSFTGHLDDVLDLSWSRSQL-LLSSSMDKTVRLWDIETQSCLKLF-AHNDY 561
Cdd:cd00200  77 -------------------LWDLETgECVRTLTGHTSYVSSVAFSPDGRiLSSSSRDKTIKVWDVETGKCLTTLrGHTDW 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 562 VTCVQFNPlDEDYFISGSLDAKIRIWNISNRQVVE-WNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKLEQTNQ 640
Cdd:cd00200 138 VNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVAtLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 641 IDLQNkkkaqakkITAFQFSPinpSEVLVTSA--DSRIRV--LDGTELVQKFRGFKNMNSQMTASYtvDAKHIVCASEDS 716
Cdd:cd00200 217 GHENG--------VNSVAFSP---DGYLLASGseDGTIRVwdLRTGECVQTLSGHTNSVTSLAWSP--DGKRLASGSADG 283


                ....*.
gi 15241815 717 QVYVWK 722
Cdd:cd00200 284 TIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 404-439 1.15e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15241815    404 CQEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWE 439
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
405-439 9.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 9.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15241815   405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWE 439
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
405-721 4.28e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 4.28e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQeceimsmnegSLTPIHpSMSGSTDkssEGDAAEVSQDkkkkGK 484
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----------TGKLLR-TLTGHTG---AVRSVAFSPD----GK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 485 TsmskkgnqipdyvhapetVFSLSDkpicsftghlddvldlswsrsqlllsssmDKTVRLWDIETQSCLKLFA-HNDYVT 563
Cdd:COG2319 218 L------------------LASGSA-----------------------------DGTVRLWDLATGKLLRTLTgHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 564 CVQFNPlDEDYFISGSLDAKIRIWNISNRQVVE-WNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKLEQTnqid 642
Cdd:COG2319 251 SVAFSP-DGRLLASGSADGTVRLWDLATGELLRtLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT---- 325

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 643 lqnkKKAQAKKITAFQFSPiNPSEVLVTSADSRIRV--LDGTELVQKFRGFKnmNSQMTASYTVDAKHIVCASEDSQVYV 720
Cdd:COG2319 326 ----LTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHT--GAVTSVAFSPDGRTLASGSADGTVRL 398


                .
gi 15241815 721 W 721
Cdd:COG2319 399 W 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 405-722 3.02e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.59  E-value: 3.02e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQECEIMSMNEGSLTPIHPSMSGSTDKSsegdAAEVSQDKKKKgk 484
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY----LASGSSDKTIR-- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 485 tsmskkgnqipdyvhapetVFSLSD-KPICSFTGHLDDVLDLSWSRSQL-LLSSSMDKTVRLWDIETQSCLKLF-AHNDY 561
Cdd:cd00200  77 -------------------LWDLETgECVRTLTGHTSYVSSVAFSPDGRiLSSSSRDKTIKVWDVETGKCLTTLrGHTDW 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 562 VTCVQFNPlDEDYFISGSLDAKIRIWNISNRQVVE-WNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKLEQTNQ 640
Cdd:cd00200 138 VNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVAtLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 641 IDLQNkkkaqakkITAFQFSPinpSEVLVTSA--DSRIRV--LDGTELVQKFRGFKNMNSQMTASYtvDAKHIVCASEDS 716
Cdd:cd00200 217 GHENG--------VNSVAFSP---DGYLLASGseDGTIRVwdLRTGECVQTLSGHTNSVTSLAWSP--DGKRLASGSADG 283


                ....*.
gi 15241815 717 QVYVWK 722
Cdd:cd00200 284 TIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
539-728 9.15e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 9.15e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 539 DKTVRLWDIETQSCLK-LFAHNDYVTCVQFNPlDEDYFISGSLDAKIRIWNISNRQVV-EWNDLKEMVTAVCYTPDGQAA 616
Cdd:COG2319 141 DGTVRLWDLATGKLLRtLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSPDGKLL 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 617 FVGSINGHCRLYSAEDCKLEQTNQIDlqnkkkaqAKKITAFQFSPiNPSEVLVTSADSRIRV--LDGTELVQKFRGFKnm 694
Cdd:COG2319 220 ASGSADGTVRLWDLATGKLLRTLTGH--------SGSVRSVAFSP-DGRLLASGSADGTVRLwdLATGELLRTLTGHS-- 288

                       170       180       190
                ....*....|....*....|....*....|....
gi 15241815 695 NSQMTASYTVDAKHIVCASEDSQVYVWKHEEPRL 728
Cdd:COG2319 289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
405-680 9.15e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 9.15e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQECEIMSMNEGSLTPIHpsmsgstdkssegdAAEVSQDkkkkGK 484
Cdd:COG2319 198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR--------------SVAFSPD----GR 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 485 tsmskkgnqipdyvhapeTVFSLSDkpicsftghlddvldlswsrsqlllsssmDKTVRLWDIETQSCLKLFA-HNDYVT 563
Cdd:COG2319 260 ------------------LLASGSA-----------------------------DGTVRLWDLATGELLRTLTgHSGGVN 292

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 564 CVQFNPlDEDYFISGSLDAKIRIWNISNRQVV-EWNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKLEQTnqid 642
Cdd:COG2319 293 SVAFSP-DGKLLASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---- 367

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 15241815 643 lqnkKKAQAKKITAFQFSPinPSEVLVT-SADSRIRVLD 680
Cdd:COG2319 368 ----LTGHTGAVTSVAFSP--DGRTLASgSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 397-678 1.80e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 1.80e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 397 DLSALHMCQEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQeceimsmnegsltpihpsmsgstdkssegdaaevs 476
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE----------------------------------- 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 477 qdkkkkgktsmskkgnqipdyvhapetvfslSDKPICSFTGHLDDVLD-LSWSRSQLLLSSSMDKTVRLWDIETQSCLKL 555
Cdd:cd00200 124 -------------------------------TGKCLTTLRGHTDWVNSvAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 556 F-AHNDYVTCVQFNPlDEDYFISGSLDAKIRIWNISNRQVVEWNDLKEM-VTAVCYTPDGQAAFVGSINGHCRLYSAEDC 633
Cdd:cd00200 173 LtGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 15241815 634 KLEQTnqidlqnkKKAQAKKITAFQFSPiNPSEVLVTSADSRIRV 678
Cdd:cd00200 252 ECVQT--------LSGHTNSVTSLAWSP-DGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
405-632 2.17e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 2.17e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQECEIMSMNEGSLTPIHpsmsgstdkssegdAAEVSQDkkkkGK 484
Cdd:COG2319 240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN--------------SVAFSPD----GK 301

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 485 tsmskkgnqipdyvhapeTVFSLSDkpicsftghlddvldlswsrsqlllsssmDKTVRLWDIETQSCLKLF-AHNDYVT 563
Cdd:COG2319 302 ------------------LLASGSD-----------------------------DGTVRLWDLATGKLLRTLtGHTGAVR 334

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 564 CVQFNPlDEDYFISGSLDAKIRIWNISNRQVV-EWNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAED 632
Cdd:COG2319 335 SVAFSP-DGKTLASGSDDGTVRLWDLATGELLrTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 539-728 3.34e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 3.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 539 DKTVRLWDIETQSCLK-------------------------------------------LFAHNDYVTCVQFNPlDEDYF 575
Cdd:cd00200  30 DGTIKVWDLETGELLRtlkghtgpvrdvaasadgtylasgssdktirlwdletgecvrtLTGHTSYVSSVAFSP-DGRIL 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 576 ISGSLDAKIRIWNI-SNRQVVEWNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKLEQTNqidlqnkkKAQAKKI 654
Cdd:cd00200 109 SSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL--------TGHTGEV 180

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15241815 655 TAFQFSPINpSEVLVTSADSRIRV--LDGTELVQKFRGFKnmNSQMTASYTVDAKHIVCASEDSQVYVWKHEEPRL 728
Cdd:cd00200 181 NSVAFSPDG-EKLLSSSSDGTIKLwdLSTGKCLGTLRGHE--NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
539-721 2.64e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 2.64e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 539 DKTVRLWDIETQSCLK-LFAHNDYVTCVQFNPlDEDYFISGSLDAKIRIWNISNRQ-VVEWNDLKEMVTAVCYTPDGQAA 616
Cdd:COG2319  57 DLTLLLLDAAAGALLAtLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLlLRTLTGHTGAVRSVAFSPDGKTL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 617 FVGSINGHCRLYSAEDCKLEQTnqidlqnkKKAQAKKITAFQFSPinPSEVLVT-SADSRIRV--LDGTELVQKFRGFKn 693
Cdd:COG2319 136 ASGSADGTVRLWDLATGKLLRT--------LTGHSGAVTSVAFSP--DGKLLASgSDDGTVRLwdLATGKLLRTLTGHT- 204

                       170       180
                ....*....|....*....|....*...
gi 15241815 694 mNSQMTASYTVDAKHIVCASEDSQVYVW 721
Cdd:COG2319 205 -GAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 397-588 6.08e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 6.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 397 DLSALHMCQEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQeceimsmnegsltpihpsmsgstdkssegdaaevs 476
Cdd:cd00200 163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----------------------------------- 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 477 qdkkkKGKTSMSKKGNQipDYVHApeTVFSLSDKPICSftghlddvldlswsrsqlllsSSMDKTVRLWDIETQSCLK-L 555
Cdd:cd00200 208 -----TGKCLGTLRGHE--NGVNS--VAFSPDGYLLAS---------------------GSEDGTIRVWDLRTGECVQtL 257

                       170       180       190
                ....*....|....*....|....*....|...
gi 15241815 556 FAHNDYVTCVQFNPlDEDYFISGSLDAKIRIWN 588
Cdd:cd00200 258 SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 404-439 1.15e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15241815    404 CQEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWE 439
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 549-588 2.28e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.28e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 15241815    549 TQSCLK-LFAHNDYVTCVQFNPlDEDYFISGSLDAKIRIWN 588
Cdd:smart00320   1 SGELLKtLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
397-441 4.18e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 4.18e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15241815 397 DLSALHMCQEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWEVQ 441
Cdd:COG2319 358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
405-439 9.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 9.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15241815   405 QEIQAHQGGIWTMKFSPDSHLLASAGEDCAIHVWE 439
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
554-588 9.90e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 9.90e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15241815   554 KLFAHNDYVTCVQFNPlDEDYFISGSLDAKIRIWN 588
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
539-721 1.54e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 539 DKTVRLWDIETQSCLKLFAHNDYVTCVQFNPLDEDYFISGSLDAKIRIWNISNRQVV-EWNDLKEMVTAVCYTPDGQAAF 617
Cdd:COG2319  15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLaTLLGHTAAVLSVAFSPDGRLLA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 618 VGSINGHCRLYSAEDCKLEQTnqidlqnkKKAQAKKITAFQFSPiNPSEVLVTSADSRIRV--LDGTELVQKFRGFKNMN 695
Cdd:COG2319  95 SASADGTVRLWDLATGLLLRT--------LTGHTGAVRSVAFSP-DGKTLASGSADGTVRLwdLATGKLLRTLTGHSGAV 165

                       170       180
                ....*....|....*....|....*.
gi 15241815 696 SqmTASYTVDAKHIVCASEDSQVYVW 721
Cdd:COG2319 166 T--SVAFSPDGKLLASGSDDGTVRLW 189
WD40 COG2319
WD40 repeat [General function prediction only];
397-591 5.15e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 5.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 397 DLSALHMCQEIQAHQGGIWTMKFSPDSHLLASAGEdcaihvwevqeceimsmnegsltpihpsmsgstdkssegdaaevs 476
Cdd:COG2319 316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD--------------------------------------------- 350

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 477 qdkkkkgktsmskkgnqipdyvhapetvfslsdkpicsftghlddvldlswsrsqlllsssmDKTVRLWDIETQSCLK-L 555
Cdd:COG2319 351 --------------------------------------------------------------DGTVRLWDLATGELLRtL 368

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 15241815 556 FAHNDYVTCVQFNPlDEDYFISGSLDAKIRIWNISN 591
Cdd:COG2319 369 TGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 542-629 1.27e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.83  E-value: 1.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241815 542 VRLWDIETqSCLKLFA----HNDY--------VTCVQF-NPLDEDYFISGSLDAKIRIWNIS--NRQVVEWnDLKEM-VT 605
Cdd:cd22857 150 LNVWDLEE-KPGKIWRaknvPNDSlglrvpvwVTDLTFlSKDDHRKIVTGTGYHQVRLYDTRaqRRPVVSV-DFGETpIK 227

                        90       100
                ....*....|....*....|....
gi 15241815 606 AVCYTPDGQAAFVGsiNGHCRLYS 629
Cdd:cd22857 228 AVAEDPDGHTVYVG--DTSGDLAS 249
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 585-635 1.95e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 1.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15241815   585 RIWNISNrqvvewNDLKEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKL 635
Cdd:pfam12894  28 RVWTLSP------DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKI 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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