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Conserved domains on  [gi|15242609|ref|NP_195922|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
105-198 3.00e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.59  E-value: 3.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609 105 QQYPQYPTVVSNGS------QIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKM-RQPRVYPAASVIDGKIYVIGGFRGSM 177
Cdd:COG3055   4 SSLPDLPTPRSEAAaalldgKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83

                        90       100
                ....*....|....*....|..
gi 15242609 178 P-TDIENSGEVYDPKTNTWEPI 198
Cdd:COG3055  84 PsSTPLNDVYVYDPATNTWTKL 105
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 22-60 1.03e-11

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 59.12  E-value: 1.03e-11
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15242609  22 DDVALDCRARISRFHYPTLSLVSKGFRTLIASPELEATR 60
Cdd:cd22152   7 DDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
105-198 3.00e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.59  E-value: 3.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609 105 QQYPQYPTVVSNGS------QIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKM-RQPRVYPAASVIDGKIYVIGGFRGSM 177
Cdd:COG3055   4 SSLPDLPTPRSEAAaalldgKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83

                        90       100
                ....*....|....*....|..
gi 15242609 178 P-TDIENSGEVYDPKTNTWEPI 198
Cdd:COG3055  84 PsSTPLNDVYVYDPATNTWTKL 105
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 22-60 1.03e-11

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 59.12  E-value: 1.03e-11
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15242609  22 DDVALDCRARISRFHYPTLSLVSKGFRTLIASPELEATR 60
Cdd:cd22152   7 DDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 154-198 2.38e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.01  E-value: 2.38e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15242609   154 PRVYPAASVIDGKIYVIGGFRGSMPTdieNSGEVYDPKTNTWEPI 198
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSL---NSVEVYDPETNTWSKL 42
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 107-198 3.15e-09

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 57.49  E-value: 3.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609   107 YPQYPTVVSNGS------QIYIIGGFVRRRRSNRVSIFDYRTY--QWRRLPKMR-QPRVYPAASVIDGKIYVIGGFRGSM 177
Cdd:TIGR03548 108 LPSLPVAFDNGSatykdgKIYVGGGNANGKPSNKFYCLDLSNDtsGWEELPEFPgEARVQPVCQALHGKLYVFGGFQLGG 187

                          90       100
                  ....*....|....*....|.
gi 15242609   178 PTDIENSGEVYDPKTNTWEPI 198
Cdd:TIGR03548 188 DAIIYTDGYAYSPKTNTWQTV 208
PHA03098 PHA03098
kelch-like protein; Provisional
 37-196 8.78e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 56.70  E-value: 8.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609   37 YPTLSLVSKGFRTLIASPE----LEATRSFIGKPE---NHLCVCLRLYKNPN-------------------PLWFIFSPI 90
Cdd:PHA03098 187 YKDICLILKVLRITFLSEEgikkLKRWKLRIKKKKivfNKRCIKIIYSKKYNlnkilprsstfgsiiyihiTMSIFTYNY 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609   91 -----PKQKLKPIVpwfpNQQYPQYPTVVSNGSQIYIIGGFVRRRRSNRVSI-FDYRTYQWRRLPKMRQPRVYPAASVID 164
Cdd:PHA03098 267 itnysPLSEINTII----DIHYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVsYDTKTKSWNKVPELIYPRKNPGVTVFN 342

                        170       180       190
                 ....*....|....*....|....*....|..
gi 15242609  165 GKIYVIGGFRGSMPTdieNSGEVYDPKTNTWE 196
Cdd:PHA03098 343 NRIYVIGGIYNSISL---NTVESWKPGESKWR 371
Kelch smart00612
Kelch domain;
119-165 2.84e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 2.84e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 15242609    119 QIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKMRQPRVYPAASVIDG 165
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
105-198 3.00e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 80.59  E-value: 3.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609 105 QQYPQYPTVVSNGS------QIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKM-RQPRVYPAASVIDGKIYVIGGFRGSM 177
Cdd:COG3055   4 SSLPDLPTPRSEAAaalldgKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83

                        90       100
                ....*....|....*....|..
gi 15242609 178 P-TDIENSGEVYDPKTNTWEPI 198
Cdd:COG3055  84 PsSTPLNDVYVYDPATNTWTKL 105
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-198 1.49e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 78.66  E-value: 1.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609 112 TVVSNGsQIYIIGGFVRRRRSNRVS----IFDYRTYQWRRLPKMRQPRVYPAASVIDGKIYVIGGFRGSMPTdieNSGEV 187
Cdd:COG3055  66 AVAQDG-KLYVFGGFTGANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV---AWVEV 141

                        90
                ....*....|.
gi 15242609 188 YDPKTNTWEPI 198
Cdd:COG3055 142 YDPATGTWTQL 152
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
109-198 4.29e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.56  E-value: 4.29e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609 109 QYPTVVSNGSQIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKMRQPRVYPAASVI-DGKIYVIGGFRGS----------- 176
Cdd:COG3055 113 GGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNGSgfsntwttlap 192

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15242609 177 MPT---------------------DIENSGEVYDPKTNTWEPI 198
Cdd:COG3055 193 LPTaraghaaavlggkilvfggesGFSDEVEAYDPATNTWTAL 235
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
144-198 8.13e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 64.79  E-value: 8.13e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15242609 144 QWRRLPKMRQPRVYPAASVIDGKIYVIGGFRGSMPTdieNSGEVYDPKTNTWEPI 198
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAS---NSFEVYDPATNTWSEL 53
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 22-60 1.03e-11

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 59.12  E-value: 1.03e-11
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15242609  22 DDVALDCRARISRFHYPTLSLVSKGFRTLIASPELEATR 60
Cdd:cd22152   7 DDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 154-198 2.38e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.01  E-value: 2.38e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15242609   154 PRVYPAASVIDGKIYVIGGFRGSMPTdieNSGEVYDPKTNTWEPI 198
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSL---NSVEVYDPETNTWSKL 42
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 107-198 3.15e-09

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 57.49  E-value: 3.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609   107 YPQYPTVVSNGS------QIYIIGGFVRRRRSNRVSIFDYRTY--QWRRLPKMR-QPRVYPAASVIDGKIYVIGGFRGSM 177
Cdd:TIGR03548 108 LPSLPVAFDNGSatykdgKIYVGGGNANGKPSNKFYCLDLSNDtsGWEELPEFPgEARVQPVCQALHGKLYVFGGFQLGG 187

                          90       100
                  ....*....|....*....|.
gi 15242609   178 PTDIENSGEVYDPKTNTWEPI 198
Cdd:TIGR03548 188 DAIIYTDGYAYSPKTNTWQTV 208
PHA03098 PHA03098
kelch-like protein; Provisional
 37-196 8.78e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 56.70  E-value: 8.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609   37 YPTLSLVSKGFRTLIASPE----LEATRSFIGKPE---NHLCVCLRLYKNPN-------------------PLWFIFSPI 90
Cdd:PHA03098 187 YKDICLILKVLRITFLSEEgikkLKRWKLRIKKKKivfNKRCIKIIYSKKYNlnkilprsstfgsiiyihiTMSIFTYNY 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609   91 -----PKQKLKPIVpwfpNQQYPQYPTVVSNGSQIYIIGGFVRRRRSNRVSI-FDYRTYQWRRLPKMRQPRVYPAASVID 164
Cdd:PHA03098 267 itnysPLSEINTII----DIHYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVsYDTKTKSWNKVPELIYPRKNPGVTVFN 342

                        170       180       190
                 ....*....|....*....|....*....|..
gi 15242609  165 GKIYVIGGFRGSMPTdieNSGEVYDPKTNTWE 196
Cdd:PHA03098 343 NRIYVIGGIYNSISL---NTVESWKPGESKWR 371
PHA03098 PHA03098
kelch-like protein; Provisional
 102-195 2.00e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 55.54  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609  102 FPNQQYP-QYPTVVSNGSQIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKMRQPRVYPAASVIDGKIYVIGGFRGSMptD 180
Cdd:PHA03098 326 VPELIYPrKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKND--E 403

                         90
                 ....*....|....*
gi 15242609  181 IENSGEVYDPKTNTW 195
Cdd:PHA03098 404 LLKTVECFSLNTNKW 418
Kelch smart00612
Kelch domain;
119-165 2.84e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 2.84e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 15242609    119 QIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKMRQPRVYPAASVIDG 165
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
166-198 4.12e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.09  E-value: 4.12e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15242609    166 KIYVIGGFRGSMPTdieNSGEVYDPKTNTWEPI 198
Cdd:smart00612   1 KIYVVGGFDGGQRL---KSVEVYDPETNKWTPL 30
PHA03098 PHA03098
kelch-like protein; Provisional
 114-197 4.45e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 54.39  E-value: 4.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609  114 VSNGSQIYIIGGFVRRRRSNRVSI---FDYRTYQWRRLPKMRQPRVYPAASVIDGKIYVIGGFRGSMPTDIEnsgEVYDP 190
Cdd:PHA03098 434 IYHDGKIYVIGGISYIDNIKVYNIvesYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEI---EVYDD 510


                 ....*..
gi 15242609  191 KTNTWEP 197
Cdd:PHA03098 511 KTNTWTL 517
PHA03098 PHA03098
kelch-like protein; Provisional
 103-211 1.83e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 52.46  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609  103 PNQQYPQY-PTVVSNGSQIYIIGG-FVRRRRSNRVSIFDYRTYQWRRLPKMRQPRVYPAASVIDGKIYVIGGFRGSMPTD 180
Cdd:PHA03098 374 PPLIFPRYnPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIK 453

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15242609  181 IENSGEVYDPKTNTWepILLTSLDLTVQNVF 211
Cdd:PHA03098 454 VYNIVESYNPVTNKW--TELSSLNFPRINAS 482
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 154-197 6.21e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 45.79  E-value: 6.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15242609   154 PRVYPAASVIDGKIYVIGGFRGSMPTDIeNSGEVYDPKTNTWEP 197
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSS-SDVLVYDPETNVWTE 43
PRK14131 PRK14131
N-acetylneuraminate epimerase;
153-196 6.39e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 47.32  E-value: 6.39e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 15242609  153 QPRVYPAASVIDGKIYVIGGFrGSMPTD----IENSGEVYDPKTNTWE 196
Cdd:PRK14131  73 GPREQAVAAFIDGKLYVFGGI-GKTNSEgspqVFDDVYKYDPKTNSWQ 119
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
110-189 1.11e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 46.30  E-value: 1.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242609 110 YPTVVSNGSQIYIIGGfvRRRRSNRVSIFDYRTYQWRRLPKMRQPRVYPAASVIDGKIYVIGGF--RGSMPTDIeNSGEV 187
Cdd:COG3055 199 GHAAAVLGGKILVFGG--ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGEtkPGVRTPLV-TSAEV 275


                ..
gi 15242609 188 YD 189
Cdd:COG3055 276 YD 277
Kelch_6 pfam13964
Kelch motif;
154-198 4.00e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 4.00e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 15242609   154 PRVYPAASVIDGKIYVIGGFrgSMPTDIENSGEVYDPKTNTWEPI 198
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGY--TNASPALNKLEVYNPLTKSWEEL 43
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 144-202 5.76e-05

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 44.62  E-value: 5.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242609   144 QWRRLPKMR-QPRVYPAASVIDGKIYVIGGF---RGSMPTDIENSGEVYDPKTNTWEPILLTS 202
Cdd:TIGR03547  42 GWQKIADFPgGPRNQAVAAAIDGKLYVFGGIgkaNSEGSPQVFDDVYRYDPKKNSWQKLDTRS 104
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 110-152 6.24e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.90  E-value: 6.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15242609   110 YPTVVSNGSQIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKMR 152
Cdd:pfam01344   4 GAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_4 pfam13418
Galactose oxidase, central domain;
154-198 3.53e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.98  E-value: 3.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15242609   154 PRVYPAASVI-DGKIYVIGGFRGSMptDIENSGEVYDPKTNTWEPI 198
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGEDG--TLLSDLWVFDLSTNEWTRL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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