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Conserved domains on  [gi|15241459|ref|NP_196410|]
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MEI2 C-terminal RRM only like 2 [Arabidopsis thaliana]

Protein Classification

RNA-binding protein( domain architecture ID 10188180)

RNA-binding protein containing an RNA recognition motif (RRM); similar to Oryza sativa protein MEI2-like 6/7

Gene Ontology:  GO:0003723
PubMed:  15853797|22278943|18515081
SCOP:  3000110

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRM3_MEI2_EAR1_like cd12277
RNA recognition motif 3 (RRM3) found in Mei2-like proteins and terminal EAR1-like proteins; ...
 137-233 3.47e-39

RNA recognition motif 3 (RRM3) found in Mei2-like proteins and terminal EAR1-like proteins; This subfamily corresponds to the RRM3 of Mei2-like proteins from plant and fungi, terminal EAR1-like proteins from plant, and other eukaryotic homologs. Mei2-like proteins represent an ancient eukaryotic RNA-binding proteins family whose corresponding Mei2-like genes appear to have arisen early in eukaryote evolution, been lost from some lineages such as Saccharomyces cerevisiae and metazoans, and diversified in the plant lineage. The plant Mei2-like genes may function in cell fate specification during development, rather than as stimulators of meiosis. In the fission yeast Schizosaccharomyces pombe, the Mei2 protein is an essential component of the switch from mitotic to meiotic growth. S. pombe Mei2 stimulates meiosis in the nucleus upon binding a specific non-coding RNA. The terminal EAR1-like protein 1 and 2 (TEL1 and TEL2) are mainly found in land plants. They may play a role in the regulation of leaf initiation. All members in this family are putative RNA-binding proteins carrying three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). In addition to the RRMs, the terminal EAR1-like proteins also contain TEL characteristic motifs that allow sequence and putative functional discrimination between them and Mei2-like proteins.


:

Pssm-ID: 409719 [Multi-domain]  Cd Length: 86  Bit Score: 131.98  E-value: 3.47e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459 137 VMLRNIPNRYTREMMIQFMDKHCEEanksgkneeftiSAYDFIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNKPW 216
Cdd:cd12277   1 VMLRNIPNKYTQEMLLQEIDEHGKG------------GAYDFFYLPLDFKTKCNVGYAFINFINPEAAERFYKAFNGKKW 68

                        90
                ....*....|....*..
gi 15241459 217 CHFYSKKELEITYARIQ 233
Cdd:cd12277  69 KNFPSKKVCDISYARLQ 85
 
Name Accession Description Interval E-value
RRM3_MEI2_EAR1_like cd12277
RNA recognition motif 3 (RRM3) found in Mei2-like proteins and terminal EAR1-like proteins; ...
 137-233 3.47e-39

RNA recognition motif 3 (RRM3) found in Mei2-like proteins and terminal EAR1-like proteins; This subfamily corresponds to the RRM3 of Mei2-like proteins from plant and fungi, terminal EAR1-like proteins from plant, and other eukaryotic homologs. Mei2-like proteins represent an ancient eukaryotic RNA-binding proteins family whose corresponding Mei2-like genes appear to have arisen early in eukaryote evolution, been lost from some lineages such as Saccharomyces cerevisiae and metazoans, and diversified in the plant lineage. The plant Mei2-like genes may function in cell fate specification during development, rather than as stimulators of meiosis. In the fission yeast Schizosaccharomyces pombe, the Mei2 protein is an essential component of the switch from mitotic to meiotic growth. S. pombe Mei2 stimulates meiosis in the nucleus upon binding a specific non-coding RNA. The terminal EAR1-like protein 1 and 2 (TEL1 and TEL2) are mainly found in land plants. They may play a role in the regulation of leaf initiation. All members in this family are putative RNA-binding proteins carrying three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). In addition to the RRMs, the terminal EAR1-like proteins also contain TEL characteristic motifs that allow sequence and putative functional discrimination between them and Mei2-like proteins.


Pssm-ID: 409719 [Multi-domain]  Cd Length: 86  Bit Score: 131.98  E-value: 3.47e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459 137 VMLRNIPNRYTREMMIQFMDKHCEEanksgkneeftiSAYDFIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNKPW 216
Cdd:cd12277   1 VMLRNIPNKYTQEMLLQEIDEHGKG------------GAYDFFYLPLDFKTKCNVGYAFINFINPEAAERFYKAFNGKKW 68

                        90
                ....*....|....*..
gi 15241459 217 CHFYSKKELEITYARIQ 233
Cdd:cd12277  69 KNFPSKKVCDISYARLQ 85
RRM_2 pfam04059
RNA recognition motif 2;
135-242 1.41e-23

RNA recognition motif 2;


Pssm-ID: 112856  Cd Length: 97  Bit Score: 91.85  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459   135 TTVMLRNIPNRYTREMMIQFMDKHCEeanksgkneeftiSAYDFIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNK 214
Cdd:pfam04059   2 TTLMIKNIPNKYTQKMLLAAIDEKNK-------------GTYDFLYLPIDFKNKCNVGYAFINMIEPQSIIPFGKAFNGK 68

                          90       100
                  ....*....|....*....|....*....
gi 15241459   215 PWCHFYSKKELEITYARIQANE-LVKRFQ 242
Cdd:pfam04059  69 KWEKFNSEKVASLAYARIQGKDaLIAHFQ 97
RRM smart00360
RNA recognition motif;
136-216 6.43e-06

RNA recognition motif;


Pssm-ID: 214636 [Multi-domain]  Cd Length: 73  Bit Score: 43.35  E-value: 6.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459    136 TVMLRNIPNRYTREMMIQFMDKHceeanksGKNEEftisaydfIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNKP 215
Cdd:smart00360   1 TLFVGNLPPDTTEEELRELFSKF-------GKVES--------VRLVRDKETGKSKGFAFVEFESEEDAEKALEALNGKE 65


                   .
gi 15241459    216 W 216
Cdd:smart00360  66 L 66
 
Name Accession Description Interval E-value
RRM3_MEI2_EAR1_like cd12277
RNA recognition motif 3 (RRM3) found in Mei2-like proteins and terminal EAR1-like proteins; ...
 137-233 3.47e-39

RNA recognition motif 3 (RRM3) found in Mei2-like proteins and terminal EAR1-like proteins; This subfamily corresponds to the RRM3 of Mei2-like proteins from plant and fungi, terminal EAR1-like proteins from plant, and other eukaryotic homologs. Mei2-like proteins represent an ancient eukaryotic RNA-binding proteins family whose corresponding Mei2-like genes appear to have arisen early in eukaryote evolution, been lost from some lineages such as Saccharomyces cerevisiae and metazoans, and diversified in the plant lineage. The plant Mei2-like genes may function in cell fate specification during development, rather than as stimulators of meiosis. In the fission yeast Schizosaccharomyces pombe, the Mei2 protein is an essential component of the switch from mitotic to meiotic growth. S. pombe Mei2 stimulates meiosis in the nucleus upon binding a specific non-coding RNA. The terminal EAR1-like protein 1 and 2 (TEL1 and TEL2) are mainly found in land plants. They may play a role in the regulation of leaf initiation. All members in this family are putative RNA-binding proteins carrying three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). In addition to the RRMs, the terminal EAR1-like proteins also contain TEL characteristic motifs that allow sequence and putative functional discrimination between them and Mei2-like proteins.


Pssm-ID: 409719 [Multi-domain]  Cd Length: 86  Bit Score: 131.98  E-value: 3.47e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459 137 VMLRNIPNRYTREMMIQFMDKHCEEanksgkneeftiSAYDFIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNKPW 216
Cdd:cd12277   1 VMLRNIPNKYTQEMLLQEIDEHGKG------------GAYDFFYLPLDFKTKCNVGYAFINFINPEAAERFYKAFNGKKW 68

                        90
                ....*....|....*..
gi 15241459 217 CHFYSKKELEITYARIQ 233
Cdd:cd12277  69 KNFPSKKVCDISYARLQ 85
RRM3_EAR1_like cd12530
RNA recognition motif 3 (RRM3) found in terminal EAR1-like proteins; This subgroup corresponds ...
 135-233 5.35e-34

RNA recognition motif 3 (RRM3) found in terminal EAR1-like proteins; This subgroup corresponds to the RRM3 of terminal EAR1-like proteins, including terminal EAR1-like protein 1 and 2 (TEL1 and TEL2) found in land plants. They may play a role in the regulation of leaf initiation. The terminal EAR1-like proteins are putative RNA-binding proteins carrying three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and TEL characteristic motifs that allow sequence and putative functional discrimination between the terminal EAR1-like proteins and Mei2-like proteins.


Pssm-ID: 240974  Cd Length: 101  Bit Score: 119.18  E-value: 5.35e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459 135 TTVMLRNIPNRYTREMMIQFMDKHCEEANKSGKNEEFTISAYDFIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNK 214
Cdd:cd12530   2 TTLMIKNIPNKYSQKLLLDMLDTHCIQCNQHIEDSSQPVSSYDFVYLPIDFKNKCNLGYAFVNFTSPEATWRFYKAFHNQ 81

                        90
                ....*....|....*....
gi 15241459 215 PWCHFYSKKELEITYARIQ 233
Cdd:cd12530  82 QWEEFNSRKICQITYARVQ 100
RRM3_MEI2_fungi cd12532
RNA recognition motif 3 (RRM3) found in fungal Mei2-like proteins; This subgroup corresponds ...
 135-236 1.01e-26

RNA recognition motif 3 (RRM3) found in fungal Mei2-like proteins; This subgroup corresponds to the RRM3 of fungal Mei2-like proteins. The Mei2 protein is an essential component of the switch from mitotic to meiotic growth in the fission yeast Schizosaccharomyces pombe. It is an RNA-binding protein that contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). In the nucleus, S. pombe Mei2 stimulates meiosis upon binding a specific non-coding RNA through its C-terminal RRM motif.


Pssm-ID: 409949  Cd Length: 90  Bit Score: 99.79  E-value: 1.01e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459 135 TTVMLRNIPNRYTREMMIQFMDKHCEEAnksgkneeftisaYDFIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNK 214
Cdd:cd12532   2 TTCMIKNIPNKFTQQMLKEYLDETNKGT-------------YDFVYLRIDFKNNCNVGYAFINFTEPESIVTFYKARQGK 68

                        90       100
                ....*....|....*....|..
gi 15241459 215 PWCHFYSKKELEITYARIQANE 236
Cdd:cd12532  69 KWNKFNSEKICDISYANIQGKD 90
RRM3_MEI2_like cd12531
RNA recognition motif 3 (RRM3) found in plant Mei2-like proteins; This subgroup corresponds to ...
 137-233 6.75e-26

RNA recognition motif 3 (RRM3) found in plant Mei2-like proteins; This subgroup corresponds to the RRM3 of Mei2-like proteins, representing an ancient eukaryotic RNA-binding proteins family. Their corresponding Mei2-like genes appear to have arisen early in eukaryote evolution, been lost from some lineages such as Saccharomyces cerevisiae and metazoans, and diversified in the plant lineage. The plant Mei2-like genes may function in cell fate specification during development, rather than as stimulators of meiosis. Members in this family contain three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The C-terminal RRM (RRM3) is unique to Mei2-like proteins and is highly conserved between plants and fungi. To date, the intracellular localization, RNA target(s), cellular interactions and phosphorylation states of Mei2-like proteins in plants remain unclear.


Pssm-ID: 240975 [Multi-domain]  Cd Length: 86  Bit Score: 97.47  E-value: 6.75e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459 137 VMLRNIPNRYTREMMIQFMDKHCEeanksgkneeftiSAYDFIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNKPW 216
Cdd:cd12531   1 LMIKNIPNKYTQKMLLAAIDEKHR-------------GTYDFFYLPIDFKNKCNVGYAFINMISPELIVPFYKAFNGKKW 67

                        90
                ....*....|....*..
gi 15241459 217 CHFYSKKELEITYARIQ 233
Cdd:cd12531  68 EKFNSEKVCSLAYARIQ 84
RRM_2 pfam04059
RNA recognition motif 2;
135-242 1.41e-23

RNA recognition motif 2;


Pssm-ID: 112856  Cd Length: 97  Bit Score: 91.85  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459   135 TTVMLRNIPNRYTREMMIQFMDKHCEeanksgkneeftiSAYDFIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNK 214
Cdd:pfam04059   2 TTLMIKNIPNKYTQKMLLAAIDEKNK-------------GTYDFLYLPIDFKNKCNVGYAFINMIEPQSIIPFGKAFNGK 68

                          90       100
                  ....*....|....*....|....*....
gi 15241459   215 PWCHFYSKKELEITYARIQANE-LVKRFQ 242
Cdd:pfam04059  69 KWEKFNSEKVASLAYARIQGKDaLIAHFQ 97
RRM smart00360
RNA recognition motif;
136-216 6.43e-06

RNA recognition motif;


Pssm-ID: 214636 [Multi-domain]  Cd Length: 73  Bit Score: 43.35  E-value: 6.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241459    136 TVMLRNIPNRYTREMMIQFMDKHceeanksGKNEEftisaydfIYLPIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNKP 215
Cdd:smart00360   1 TLFVGNLPPDTTEEELRELFSKF-------GKVES--------VRLVRDKETGKSKGFAFVEFESEEDAEKALEALNGKE 65


                   .
gi 15241459    216 W 216
Cdd:smart00360  66 L 66
RRM_SF cd00590
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ...
 137-214 1.33e-03

RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).


Pssm-ID: 409669 [Multi-domain]  Cd Length: 72  Bit Score: 36.49  E-value: 1.33e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15241459 137 VMLRNIPNRYTREMMIQFMDKHceeanksGKNEEFTIsaydfiylpIDFRTTMNKGYAFVNFTNAKAVSKFKAACNNK 214
Cdd:cd00590   1 LFVGNLPPDTTEEDLRELFSKF-------GEVVSVRI---------VRDRDGKSKGFAFVEFESPEDAEKALEALNGT 62
RRM_eIF3G_like cd12408
RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit G ...
 179-208 3.11e-03

RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins; This subfamily corresponds to the RRM of eIF-3G and similar proteins. eIF-3G, also termed eIF-3 subunit 4, or eIF-3-delta, or eIF3-p42, or eIF3-p44, is the RNA-binding subunit of eIF3, a large multisubunit complex that plays a central role in the initiation of translation by binding to the 40 S ribosomal subunit and promoting the binding of methionyl-tRNAi and mRNA. eIF-3G binds 18 S rRNA and beta-globin mRNA, and therefore appears to be a nonspecific RNA-binding protein. eIF-3G is one of the cytosolic targets and interacts with mature apoptosis-inducing factor (AIF). eIF-3G contains one RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). This family also includes yeast eIF3-p33, a homolog of vertebrate eIF-3G, plays an important role in the initiation phase of protein synthesis in yeast. It binds both, mRNA and rRNA, fragments due to an RRM near its C-terminus.


Pssm-ID: 409842 [Multi-domain]  Cd Length: 76  Bit Score: 35.56  E-value: 3.11e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 15241459 179 IYLPIDFRTTMNKGYAFVNFTN----AKAVSKFK 208
Cdd:cd12408  29 VYLAKDKETGQSKGFAFVTFETredaERAIEKLN 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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